Details of the Target

General Information of Target

Target ID LDTP01785
Target Name Epidermal growth factor receptor (EGFR)
Gene Name EGFR
Gene ID 1956
Synonyms
ERBB; ERBB1; HER1; Epidermal growth factor receptor; EC 2.7.10.1; Proto-oncogene c-ErbB-1; Receptor tyrosine-protein kinase erbB-1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA
Target Type
Successful
Target Bioclass
Enzyme
Family
Protein kinase superfamily, Tyr protein kinase family, EGF receptor subfamily
Subcellular location
Secreted; Cell membrane
Function
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules. May also activate the NF-kappa-B signaling cascade. Also directly phosphorylates other proteins like RGS16, activating its GTPase activity and probably coupling the EGF receptor signaling to the G protein-coupled receptor signaling. Also phosphorylates MUC1 and increases its interaction with SRC and CTNNB1/beta-catenin. Positively regulates cell migration via interaction with CCDC88A/GIV which retains EGFR at the cell membrane following ligand stimulation, promoting EGFR signaling which triggers cell migration. Plays a role in enhancing learning and memory performance. Plays a role in mammalian pain signaling (long-lasting hypersensitivity).; Isoform 2 may act as an antagonist of EGF action.; (Microbial infection) Acts as a receptor for hepatitis C virus (HCV) in hepatocytes and facilitates its cell entry. Mediates HCV entry by promoting the formation of the CD81-CLDN1 receptor complexes that are essential for HCV entry and by enhancing membrane fusion of cells expressing HCV envelope glycoproteins.
TTD ID
T59328
Uniprot ID
P00533
DrugMap ID
TTZ6B2I
Ensemble ID
ENST00000275493.7
HGNC ID
HGNC:3236
ChEMBL ID
CHEMBL203

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.Q408R; p.Y1069C DBIA    Probe Info 
CHL1 SNV: p.V1011M .
COLO320 SNV: p.S1025T .
COLO679 SNV: p.S306L DBIA    Probe Info 
HCC827 Deletion: p.E746_A750del DBIA    Probe Info 
HEC1B SNV: p.A864V IA-alkyne    Probe Info 
JURKAT SNV: p.R451C .
KNS81FD SNV: p.G598V DBIA    Probe Info 
KYSE510 SNV: p.A702D DBIA    Probe Info 
LS123 Substitution: p.C307R DBIA    Probe Info 
MCC13 SNV: p.P192S; p.V336M DBIA    Probe Info 
MM1S SNV: p.G917R .
MOLT4 Deletion: p.E513RfsTer55 .
NALM6 SNV: p.R1068Ter; p.A1076T .
NCIH1650 Deletion: p.E746_A750del DBIA    Probe Info 
NCIH1793 SNV: p.C311F DBIA    Probe Info 
NCIH1975 SNV: p.T790M; p.L858R DBIA    Probe Info 
NCIH2172 SNV: p.S1130G .
NCIH2291 SNV: p.V592F DBIA    Probe Info 
NCIH358 Substitution: p.C307R DBIA    Probe Info 
PC14 Deletion: p.E746_A750del DBIA    Probe Info 
PC9 Deletion: p.E746_A750del .
RPMI8226 SNV: p.T751I .
SHP77 SNV: p.Q701R DBIA    Probe Info 
SKMEL28 SNV: p.P753S DBIA    Probe Info 
SUPT1 SNV: p.C251Y .
TC71 SNV: p.A1048S .
TGBC1TKB SNV: p.L883F DBIA    Probe Info 
TYKNU Deletion: p.A202_Q208delinsE DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.23  LDD0402  [1]
P1
 Probe Info  		2.59  LDD0448  [2]
P2
 Probe Info  		3.94  LDD0449  [2]
P3
 Probe Info  		8.57  LDD0450  [2]
P8
 Probe Info  		1.91  LDD0451  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
CY4
 Probe Info  		100.00  LDD0244  [3]
N1
 Probe Info  		100.00  LDD0242  [3]
STPyne
 Probe Info  		K479(7.69); K489(6.03); K708(7.15); K713(6.94)  LDD0277  [4]
OPA-S-S-alkyne
 Probe Info  		K133(1.08); K489(1.31); K487(1.61); K212(2.63)  LDD3494  [5]
AF-1
 Probe Info  		3.61  LDD0421  [6]
AF-2
 Probe Info  		1.91  LDD0422  [6]
BTD
 Probe Info  		C31(0.87)  LDD1700  [7]
Sulforaphane-probe2
 Probe Info  		1.56  LDD0160  [8]
DBIA
 Probe Info  		C775(1.11); C1058(1.04); C1049(0.86)  LDD0078  [9]
5E-2FA
 Probe Info  		H47(0.00); H145(0.00); H304(0.00)  LDD2235  [10]
ATP probe
 Probe Info  		K875(0.00); K867(0.00); K879(0.00)  LDD0199  [11]
IA-alkyne
 Probe Info  		C31(0.00); C215(0.00); C307(0.00); C260(0.00)  LDD0162  [12]
ATP probe
 Probe Info  		K875(0.00); K745(0.00); K867(0.00)  LDD0035  [13]
NAIA_4
 Probe Info  		C311(0.00); C1049(0.00); C1058(0.00)  LDD2226  [14]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
IPM
 Probe Info  		C1049(0.00); C248(0.00); C291(0.00); C1058(0.00)  LDD0147  [16]
PF-06672131
 Probe Info  		C337(0.00); C470(0.00); C1049(0.00)  LDD0017  [17]
TFBX
 Probe Info  		N.A.  LDD0148  [16]
Acrolein
 Probe Info  		C1049(0.00); C157(0.00); H418(0.00); C775(0.00)  LDD0217  [18]
Crotonaldehyde
 Probe Info  		C157(0.00); C215(0.00); H304(0.00)  LDD0219  [18]
Methacrolein
 Probe Info  		C157(0.00); C307(0.00); C31(0.00); C215(0.00)  LDD0218  [18]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		7.36  LDD1850  [19]
C310
 Probe Info  		8.63  LDD1977  [19]
DFG-out-4
 Probe Info  		6.10  LDD0075  [20]
DA-2
 Probe Info  		N.A.  LDD0070  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C329(0.69)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C31(0.39)  LDD2095  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C31(0.51); C219(0.71); C260(1.13); C307(1.16)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C31(1.00); C260(1.19); C307(1.09); C337(0.71)  LDD2152  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C31(0.78)  LDD2131  [7]
 LDCM0214  AC1 HCT 116 C1049(0.92); C1058(0.93); C311(0.85); C470(1.12)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C1049(0.90); C1058(1.00); C31(1.07); C311(1.73)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C1049(0.76); C1058(1.03); C215(0.70); C219(0.83)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C1049(0.78); C1058(1.07); C215(0.84); C219(0.86)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C1049(0.77); C1058(1.00); C215(0.66); C219(0.84)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C1049(1.05); C1058(1.02); C215(0.72); C219(0.89)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C1049(1.07); C1058(1.00); C215(0.70); C219(0.90)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C1049(1.12); C1058(1.11); C215(0.68); C219(0.99)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C1049(0.70); C1058(1.10); C215(0.76); C219(0.90)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C1049(1.18); C1058(1.01); C215(0.48); C219(0.72)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C1049(0.62); C1058(0.96); C215(1.12); C219(1.12)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C1049(0.71); C1058(0.96); C215(1.05); C219(1.01)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C1049(1.14); C1058(1.16); C31(0.84); C311(1.35)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C1049(0.90); C1058(1.16); C215(0.77); C219(0.65)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C1049(0.75); C1058(1.08); C215(0.89); C219(1.20)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C1049(0.80); C1058(1.10); C215(0.61); C219(0.75)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C1049(0.97); C1058(1.08); C311(0.96); C470(0.86)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C1049(1.43); C1058(0.82); C311(0.90); C470(0.87)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C1049(1.32); C1058(0.88); C311(0.89); C470(0.83)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C1049(1.20); C1058(1.13); C311(0.90); C470(0.94)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C1049(1.07); C1058(1.24); C311(0.95); C470(0.82)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C1049(1.03); C1058(1.07); C311(0.94); C470(0.78)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C1049(1.06); C1058(1.00); C311(0.97); C470(0.91)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C1049(0.93); C1058(0.96); C31(1.05); C311(1.30)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C1049(1.09); C1058(1.13); C311(1.03); C470(1.03)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C1049(0.84); C1058(1.08); C311(0.75); C470(1.02)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C1049(0.89); C1058(1.01); C311(0.96); C470(0.98)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C1049(0.98); C1058(1.42); C311(0.87); C470(0.83)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C1049(1.06); C1058(0.95); C311(0.84); C470(0.86)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C1049(1.12); C1058(0.80); C311(0.91); C470(0.96)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C1049(1.08); C1058(0.99); C311(0.83); C470(0.96)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C1049(1.18); C1058(1.00); C311(0.87); C470(0.93)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C1049(1.30); C1058(1.54); C311(0.73); C470(0.99)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C1049(1.21); C1058(1.13); C311(0.62); C470(1.16)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C1049(1.80); C1058(1.48); C311(0.87); C470(1.01)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C1049(1.31); C1058(1.21); C311(0.71); C470(1.18)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C1049(1.10); C1058(1.13); C311(0.66); C470(1.00)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C1049(1.20); C1058(1.16); C311(0.72); C470(0.97)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C1049(1.32); C1058(1.27); C311(0.81); C470(0.99)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C1049(1.43); C1058(1.42); C311(0.72); C470(1.09)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C1049(1.39); C1058(1.34); C311(0.73); C470(1.02)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C1049(1.02); C1058(1.36); C311(0.80); C470(1.04)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C1049(0.91); C1058(1.18); C311(0.65); C470(0.97)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C1049(1.24); C1058(1.16); C311(0.58); C470(1.04)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C1049(0.91); C1058(1.17); C31(0.94); C311(1.13)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C1049(1.53); C1058(1.48); C311(0.79); C470(1.00)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C1049(0.98); C1058(1.34); C311(0.75); C470(0.96)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C1049(0.98); C1058(0.97); C311(0.89); C470(1.11)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C1049(0.96); C1058(1.27); C311(0.69); C775(1.02)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C311(0.97); C1058(0.99); C775(1.15); C1049(1.16)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C311(0.82); C775(0.97); C1058(1.04); C1049(1.10)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C1049(1.02); C311(1.06); C1058(1.16); C775(1.30)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C311(0.89); C1058(1.00); C775(1.20); C1049(1.35)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C311(0.68); C1058(1.25); C775(1.28); C1049(1.43)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C311(1.07); C1058(1.13); C1049(1.26); C775(1.29)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C818(0.75); C775(0.86); C31(0.90); C1058(0.90)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C1049(1.03); C1058(1.06); C311(1.07); C775(1.35)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C311(0.97); C1049(0.98); C775(1.00); C1058(1.06)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C311(0.97); C1058(1.00); C1049(1.21); C775(1.31)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C311(1.14); C1058(1.26); C1049(1.29); C775(1.63)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C1049(1.28); C1058(1.08); C311(1.03); C775(0.99)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C1049(1.15); C1058(1.14); C311(0.90); C775(1.10)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C1049(1.10); C1058(1.22); C311(0.88); C775(1.04)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C1049(1.47); C1058(1.18); C311(0.98); C775(1.17)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C950(0.85); C818(0.86); C470(1.03); C775(1.09)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C950(0.95); C818(1.00); C470(1.02); C311(1.13)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C31(0.70); C950(0.87); C311(1.01); C775(1.01)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C950(0.94); C818(0.97); C1049(1.01); C775(1.02)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C950(0.82); C311(0.87); C31(0.89); C470(0.94)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C31(0.79); C950(0.90); C775(0.95); C470(1.00)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C950(0.74); C1049(0.96); C775(0.97); C311(0.98)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C950(0.63); C311(0.91); C818(0.96); C775(0.98)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C950(0.78); C311(0.88); C470(0.99); C1049(1.10)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C31(0.51); C950(0.85); C775(0.85); C1058(0.87)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C950(0.84); C470(0.86); C1058(1.00); C1049(1.05)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C31(0.78); C950(0.90); C470(0.99); C311(1.00)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C31(0.86); C950(0.92); C1058(0.93); C470(0.94)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C31(0.71); C950(0.95); C470(0.97); C311(1.11)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C311(0.84); C470(0.87); C818(0.94); C950(0.95)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C31(0.64); C950(0.87); C470(0.92); C1058(1.06)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C775(0.91); C950(0.94); C470(0.94); C1049(1.05)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C470(0.91); C950(1.00); C31(1.05); C1049(1.21)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C950(0.82); C31(0.97); C470(0.98); C1058(1.09)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C31(0.70); C950(0.90); C470(0.99); C775(1.13)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C1058(0.80); C311(0.88); C775(0.88); C1049(0.90)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C1049(0.76); C311(0.79); C775(0.81); C1058(0.88)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C775(0.76); C311(0.84); C1049(0.88); C1058(0.90)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C775(0.77); C311(0.81); C1049(0.86); C1058(0.94)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C1058(0.86); C470(0.93); C775(0.97); C1049(0.99)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C470(0.89); C311(0.90); C950(0.91); C818(0.96)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C1049(0.86); C775(0.93); C311(1.00); C1058(1.00)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C775(0.77); C1049(0.79); C1058(0.98); C311(0.98)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C1049(0.80); C311(0.89); C1058(1.02); C470(1.04)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C1049(0.77); C1058(1.01); C311(1.07); C950(1.08)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C1049(0.86); C775(0.94); C1058(0.96); C311(1.03)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C1049(0.96); C311(0.97); C775(1.05); C1058(1.05)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C950(0.62); C311(0.82); C215(1.03); C219(1.03)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C311(0.89); C775(0.89); C1058(0.96); C1049(1.02)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C950(0.75); C311(0.94); C775(0.98); C1058(1.04)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C950(0.62); C311(1.08); C215(1.08); C219(1.08)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C470(0.86); C950(0.96); C1049(0.99); C311(1.00)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C950(0.66); C215(0.85); C219(0.85); C311(1.04)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C950(0.58); C215(0.78); C219(0.78); C1049(0.78)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C950(0.68); C1049(0.84); C311(0.88); C775(1.00)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C950(0.60); C1049(0.85); C311(1.00); C775(1.01)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C950(0.67); C311(1.03); C470(1.06); C1049(1.07)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C950(0.80); C775(0.90); C215(0.92); C219(0.92)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C950(0.76); C775(0.94); C470(1.13); C311(1.19)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C311(0.86); C31(0.93); C470(0.96); C215(1.02)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C215(0.85); C219(0.85); C31(0.89); C311(1.01)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C470(0.76); C31(0.82); C215(0.94); C219(0.94)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C31(0.65); C818(0.72); C1049(1.07); C1058(1.09)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C311(0.92); C470(0.98); C215(1.12); C219(1.12)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C311(0.91); C1058(1.01); C470(1.05); C1049(1.09)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C215(0.80); C219(0.80); C31(0.83); C470(0.85)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C470(0.99); C311(1.05); C1058(1.06); C215(1.17)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C470(0.83); C31(0.98); C215(1.01); C219(1.01)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C215(0.81); C219(0.81); C311(0.82); C470(0.88)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C311(0.87); C215(0.90); C219(0.90); C470(0.96)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C215(0.63); C219(0.63); C470(0.72); C31(0.80)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C950(0.85); C1058(0.89); C311(1.03); C470(1.11)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C1058(0.77); C950(0.86); C470(0.98); C311(1.04)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C31(0.72); C818(0.87); C775(0.93); C1058(1.06)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C950(0.79); C1058(0.98); C470(1.07); C311(1.12)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C950(0.84); C1058(0.88); C311(0.91); C1049(0.97)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C950(0.74); C1058(0.96); C311(0.99); C470(1.00)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C950(0.82); C1058(0.88); C470(0.98); C1049(1.23)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C950(0.82); C1058(0.83); C470(0.95); C1049(1.10)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C950(0.73); C1058(1.09); C470(1.10); C1049(1.40)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C950(0.77); C470(0.96); C1058(0.99); C1049(1.14)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C950(0.68); C311(0.95); C470(1.03); C1058(1.13)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C950(0.69); C311(0.90); C1058(0.94); C1049(1.10)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C950(0.76); C1058(1.00); C470(1.06); C311(1.19)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C818(0.85); C31(0.86); C1049(0.97); C775(0.98)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C950(0.78); C1058(0.87); C1049(1.02); C470(1.05)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C950(0.69); C311(0.93); C1058(1.03); C470(1.25)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C950(0.72); C470(0.84); C1058(0.87); C311(1.03)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C470(0.96); C1058(1.29); C1049(1.31); C311(1.58)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C470(1.11); C1049(1.13); C1058(1.31); C311(1.48)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C470(1.00); C1049(1.04); C1058(1.34); C311(1.35)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C470(0.96); C1049(1.08); C1058(1.30); C311(1.37)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C1049(0.82); C1058(1.05); C470(1.12); C311(1.46)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C470(0.96); C1049(0.98); C1058(1.12); C311(1.53)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C470(1.01); C1049(1.14); C1058(1.20); C311(1.41)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C1049(0.93); C470(0.96); C1058(1.11); C311(1.45)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C470(1.01); C1049(1.30); C1058(1.41); C311(1.55)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C470(0.96); C1058(1.36); C1049(1.47); C311(1.54)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C470(1.02); C1049(1.23); C1058(1.31); C311(1.37)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C470(1.12); C1049(1.22); C311(1.41); C1058(1.47)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C1049(0.95); C1058(1.16); C311(1.24); C470(2.12)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C470(1.05); C311(1.28); C1049(1.28); C1058(1.39)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C470(0.90); C1049(1.37); C1058(1.56); C311(1.58)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C219(0.36); C215(0.40); C470(0.70); C950(0.85)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C1049(0.58); C215(0.64); C950(0.79); C470(0.82)  LDD0683  [9]
 LDCM0545  Acetamide MDA-MB-231 C31(0.24)  LDD2138  [7]
 LDCM0166  Afatinib A431 3.61  LDD0421  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C31(1.15); C1058(1.06)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C1049(0.89); C1058(0.84); C31(0.83); C311(1.18)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C818(0.72); C31(0.77); C775(0.78); C1058(0.89)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C31(0.62); C818(0.98); C775(1.02); C1058(1.11)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 11.70  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C775(1.11); C1058(1.04); C1049(0.86)  LDD0078  [9]
 LDCM0498  BS-3668 MDA-MB-231 C329(1.04)  LDD2091  [7]
 LDCM0630  CCW28-3 231MFP C1058(1.45)  LDD2214  [22]
 LDCM0108  Chloroacetamide HeLa C157(0.00); C307(0.00); C291(0.00); H418(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C775(0.83); C215(0.86); C219(0.86); C818(0.88)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C818(0.84); C215(0.88); C219(0.88); C31(0.89)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C311(0.86); C950(0.89); C818(0.92); C470(1.00)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C818(0.76); C31(0.79); C775(0.94); C1058(0.99)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C31(0.58); C775(0.71); C818(0.71); C1049(1.00)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C818(0.63); C775(0.76); C1058(0.96); C1049(1.07)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C31(0.75); C775(0.77); C818(0.89); C1049(1.07)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C31(0.61); C470(0.83); C950(0.91); C775(1.06)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C31(0.98); C470(1.02); C950(1.07); C775(1.23)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C31(0.87); C470(0.89); C950(1.03); C1049(1.14)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C470(0.88); C31(1.01); C950(1.04); C775(1.14)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C950(0.73); C31(0.77); C470(0.90); C818(0.99)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C818(0.94); C775(1.10); C470(1.11); C31(1.21)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C31(0.62); C950(0.72); C470(0.88); C775(1.16)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C31(0.59); C950(0.75); C470(0.86); C818(1.03)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C950(0.77); C470(0.87); C31(0.90); C775(0.93)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C31(0.71); C470(0.92); C950(0.95); C311(1.15)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C31(0.41); C950(0.72); C470(0.92); C311(1.16)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C31(0.73); C950(0.76); C470(0.99); C775(1.15)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C950(0.80); C31(0.87); C470(0.95); C775(0.95)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C1049(1.05); C470(1.08); C950(1.18); C215(1.20)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C775(0.89); C1058(0.96); C1049(0.98); C950(1.05)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C1049(0.96); C775(1.03); C950(1.05); C1058(1.05)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C818(0.84); C31(1.02); C470(1.12); C215(1.19)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C1049(0.85); C775(0.97); C1058(0.99); C470(1.00)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C950(0.73); C470(0.88); C1049(0.94); C775(1.00)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C950(0.65); C1049(0.83); C311(1.01); C1058(1.08)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C950(0.49); C470(0.95); C215(1.06); C219(1.06)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C950(0.61); C215(0.97); C219(0.97); C775(1.00)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C311(0.93); C470(0.99); C31(1.05); C1058(1.07)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C311(0.80); C1058(0.80); C470(0.85); C31(0.90)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C470(0.86); C31(0.87); C311(0.92); C215(0.97)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C470(0.74); C311(0.81); C31(0.83); C215(1.07)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C215(0.82); C219(0.82); C818(1.02); C31(1.09)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C818(0.88); C775(0.99); C215(1.06); C219(1.06)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C818(0.94); C775(0.98); C31(1.03); C470(1.07)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C470(0.91); C950(0.98); C311(1.08); C1049(1.25)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C311(0.72); C950(0.92); C470(1.07); C1049(1.16)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C311(0.88); C950(1.00); C1049(1.06); C470(1.41)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C311(0.82); C470(0.96); C950(1.15); C1049(1.29)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C775(0.69); C311(0.77); C1049(0.88); C215(0.89)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C470(0.90); C311(1.26); C950(1.33); C1049(1.37)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C311(0.89); C470(0.96); C950(1.32); C1049(1.34)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C470(0.92); C311(1.15); C950(1.69); C1049(1.75)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C470(0.86); C311(0.98); C950(1.03); C1049(1.27)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C470(0.92); C311(1.16); C1049(1.22); C950(1.33)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C1049(1.78); C311(0.91); C470(0.90); C950(1.30)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C1049(1.23); C311(0.93); C470(0.97); C950(1.10)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C1049(1.18); C311(1.09); C470(0.88); C950(1.06)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C1049(1.06); C311(1.19); C470(0.92); C950(1.17)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C1049(1.22); C311(1.04); C470(0.94); C950(1.27)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C1049(0.94); C215(1.06); C219(1.06); C31(0.93)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C1049(0.90); C311(1.06); C470(0.93); C950(0.94)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C1049(1.49); C1058(0.96); C311(0.99); C470(1.01)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C1049(1.21); C1058(0.80); C311(1.05); C470(1.33)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C1049(1.76); C1058(0.86); C311(0.86); C470(1.28)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C1049(1.50); C1058(0.91); C311(0.87); C470(1.11)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C1049(1.55); C1058(0.95); C311(0.84); C470(1.05)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C1049(1.43); C1058(1.07); C311(0.75); C470(1.13)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C1049(1.54); C1058(0.83); C311(0.87); C470(1.04)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C1049(1.61); C1058(0.75); C311(1.08); C470(0.91)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C1049(0.90); C215(1.13); C219(1.13); C31(1.01)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C1049(1.31); C1058(1.05); C311(0.95); C470(0.98)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C1049(1.44); C1058(1.05); C311(0.89); C470(1.10)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C1049(1.80); C1058(0.86); C311(0.83); C470(0.96)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C1049(1.69); C1058(0.95); C311(0.94); C470(1.21)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C1049(1.62); C1058(1.05); C311(0.85); C470(1.14)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C1049(1.57); C1058(0.81); C311(1.05); C470(0.98)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C1049(0.99); C215(0.71); C219(0.71); C31(1.34)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C1049(0.90); C215(0.88); C219(0.88); C31(1.17)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C1049(0.95); C215(0.93); C219(0.93); C31(0.90)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C1049(0.94); C215(1.07); C219(1.07); C31(0.94)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C1049(1.01); C215(0.96); C219(0.96); C31(1.13)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C1049(0.88); C215(1.05); C219(1.05); C31(1.45)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C1049(0.82); C215(1.02); C219(1.02); C31(0.73)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C1049(0.94); C215(1.03); C219(1.03); C31(1.20)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C1049(1.07); C215(0.99); C219(0.99); C31(0.85)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C1049(1.10); C215(0.98); C219(0.98); C31(1.01)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C1049(1.03); C215(0.84); C219(0.84); C31(1.13)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C1049(1.01); C215(0.88); C219(0.88); C31(1.04)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C1049(1.11); C215(1.06); C219(1.06); C31(1.35)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C1049(1.15); C215(0.74); C219(0.74); C31(0.89)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C1049(1.01); C215(1.10); C219(1.10); C31(1.31)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C1049(0.95); C215(1.17); C219(1.17); C31(1.39)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C1049(1.06); C215(1.09); C219(1.09); C31(0.99)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C1049(1.02); C1058(0.90); C311(0.95); C470(1.06)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C1049(1.28); C1058(0.87); C311(1.06); C470(1.17)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C1049(1.22); C1058(0.99); C311(1.27); C470(1.03)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C1049(1.43); C1058(1.35); C311(1.15); C470(1.14)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C1049(0.94); C1058(0.97); C311(1.02); C470(1.07)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C1049(1.26); C1058(1.26); C311(1.19); C470(1.23)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C1049(1.44); C1058(1.05); C311(1.29); C470(0.89)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C1049(1.15); C1058(1.22); C311(0.93); C470(0.83)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C1049(1.31); C1058(0.98); C311(1.01); C470(1.02)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C1049(1.07); C215(1.20); C219(1.20); C31(1.09)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C1049(1.11); C1058(0.91); C311(1.17); C470(0.96)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C1049(1.19); C1058(1.46); C311(1.36); C470(0.99)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C1049(0.86); C1058(1.02); C311(1.32); C470(1.23)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C1049(1.27); C1058(1.01); C311(1.24); C470(1.10)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C1049(1.20); C1058(1.17); C311(1.15); C470(1.08)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C1058(1.08); C215(0.83); C219(0.83); C470(1.00)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C1058(1.26); C215(0.72); C219(0.72); C470(0.98)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C1058(1.32); C215(0.85); C219(0.85); C470(1.23)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C1058(1.20); C215(0.78); C219(0.78); C470(1.06)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C1049(1.55); C215(1.06); C219(1.06); C31(0.93)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C1058(1.00); C215(0.98); C219(0.98); C470(1.13)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C1058(1.11); C215(0.83); C219(0.83); C470(1.05)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C1058(1.48); C215(0.80); C219(0.80); C470(1.11)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C1058(1.42); C215(0.83); C219(0.83); C470(0.98)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C1058(1.71); C215(0.79); C219(0.79); C470(1.06)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C1058(1.03); C215(0.75); C219(0.75); C470(1.07)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C1058(0.95); C215(0.79); C219(0.79); C470(1.04)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C1058(1.28); C215(0.94); C219(0.94); C470(0.89)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C1058(1.59); C215(0.84); C219(0.84); C470(1.03)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C1058(1.47); C215(0.84); C219(0.84); C470(1.00)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C1049(0.96); C215(1.12); C219(1.12); C31(1.28)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C1058(1.08); C215(0.72); C219(0.72); C470(0.81)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C1049(1.20); C1058(1.14); C311(1.09); C470(0.95)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C1049(1.24); C1058(1.21); C311(0.96); C470(0.84)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C1049(0.99); C1058(1.03); C311(0.88); C470(0.90)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C1049(1.24); C1058(1.26); C311(0.85); C470(0.89)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C1049(1.22); C1058(1.25); C311(0.94); C470(0.98)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C1049(1.13); C1058(1.38); C311(1.00); C470(0.83)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C1049(1.29); C1058(1.16); C311(0.96); C470(1.22)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C1049(1.35); C1058(1.08); C311(0.98); C470(1.03)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C1049(1.02); C1058(1.15); C311(0.95); C470(0.93)  LDD0811  [9]
 LDCM0017  DFG-out-2 A431 6.10  LDD0075  [20]
 LDCM0495  E2913 HEK-293T C31(1.07); C950(1.12); C775(1.11)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C818(9.28); C950(3.49); C219(1.29); C31(1.26)  LDD1702  [7]
 LDCM0468  Fragment33 HCT 116 C1049(1.25); C1058(1.22); C311(1.38); C470(1.16)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C1049(1.82); C1058(1.62); C311(0.79); C470(0.99)  LDD0744  [9]
 LDCM0107  IAA HeLa H418(0.00); H145(0.00); C157(0.00); H383(0.00)  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C939(1.01); C31(0.99)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C939(0.96); C31(1.04)  LDD1497  [23]
 LDCM0024  KB05 G361 C539(1.83); C157(2.95); C337(2.08); C470(5.78)  LDD3311  [24]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C31(0.46)  LDD2121  [7]
 LDCM0109  NEM HeLa H418(0.00); H888(0.00); H988(0.00); H383(0.00)  LDD0223  [18]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C31(0.44)  LDD2089  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C31(0.89)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C31(0.47); C260(0.85)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C31(1.12)  LDD2094  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C337(0.81)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C31(0.78)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C31(0.83); C260(0.93)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C31(0.55)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C31(1.36); C219(1.31)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C31(0.83)  LDD2104  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C329(0.75)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C31(0.95); C260(1.05); C337(1.03); C329(0.61)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C31(0.45); C307(0.97); C337(1.12)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C329(1.22)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C337(0.80)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C31(0.70)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C31(0.89); C219(0.96); C329(0.51)  LDD2115  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C31(0.96)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C31(0.72); C307(0.29)  LDD2120  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C31(0.37); C260(0.78); C307(0.88); C337(1.17)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C31(0.36); C219(0.81); C307(0.97); C291(0.73)  LDD2125  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C31(0.43); C219(0.66)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C31(0.76); C337(0.34)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C31(0.32); C219(1.02); C260(0.99)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C31(1.20)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C219(1.70); C329(0.49)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C31(0.25); C219(1.14); C329(0.87)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C31(0.62); C219(0.95); C307(1.45); C337(1.46)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C31(0.85); C219(0.71); C260(1.10); C307(0.74)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C31(0.87)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C31(0.56); C260(0.91); C337(0.61)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C31(1.09); C307(0.31)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C31(1.55); C260(1.16); C307(1.16); C337(1.37)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C31(0.44); C307(0.87); C337(0.98); C329(0.79)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C31(4.15)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C31(0.59); C219(1.32)  LDD2148  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C31(0.33)  LDD2150  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C1058(1.94)  LDD2153  [7]
 LDCM0003  Sulforaphane MDA-MB-231 1.56  LDD0160  [8]
 LDCM0021  THZ1 HCT 116 C775(1.02); C31(0.81)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 57 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein argonaute-2 (AGO2) Argonaute family Q9UKV8
DNA excision repair protein ERCC-1 (ERCC1) ERCC1/RAD10/SWI10 family P07992
Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) Glyceraldehyde-3-phosphate dehydrogenase family P04406
Acidic mammalian chitinase (CHIA) Glycosyl hydrolase 18 family Q9BZP6
Heat shock cognate 71 kDa protein (HSPA8) Heat shock protein 70 family P11142
Heat shock protein HSP 90-alpha (HSP90AA1) Heat shock protein 90 family P07900
Histone deacetylase 6 (HDAC6) Histone deacetylase family Q9UBN7
Histone deacetylase 7 (HDAC7) Histone deacetylase family Q8WUI4
Macrophage migration inhibitory factor (MIF) MIF family P14174
Ubiquitin carboxyl-terminal hydrolase isozyme L1 (UCHL1) Peptidase C12 family P09936
Phosphatidylinositol 4-phosphate 3-kinase C2 domain-containing subunit beta (PIK3C2B) PI3/PI4-kinase family O00750
Protein phosphatase 1A (PPM1A) PP2C family P35813
Microtubule-associated serine/threonine-protein kinase 1 (MAST1) AGC Ser/Thr protein kinase family Q9Y2H9
Protein kinase C alpha type (PRKCA) AGC Ser/Thr protein kinase family P17252
Cyclin-dependent kinase 1 (CDK1) CMGC Ser/Thr protein kinase family P06493
Aurora kinase A (AURKA) Ser/Thr protein kinase family O14965
Mitogen-activated protein kinase kinase kinase 12 (MAP3K12) STE Ser/Thr protein kinase family Q12852
Leucine-rich repeat serine/threonine-protein kinase 1 (LRRK1) TKL Ser/Thr protein kinase family Q38SD2
Hepatocyte growth factor receptor (MET) Tyr protein kinase family P08581
Tyrosine-protein kinase ABL1 (ABL1) Tyr protein kinase family P00519
Tyrosine-protein kinase ABL2 (ABL2) Tyr protein kinase family P42684
Tyrosine-protein kinase receptor UFO (AXL) Tyr protein kinase family P30530
Platelet-derived growth factor receptor alpha (PDGFRA) Tyr protein kinase family P16234
Epidermal growth factor receptor (EGFR) Tyr protein kinase family P00533
Receptor tyrosine-protein kinase erbB-2 (ERBB2) Tyr protein kinase family P04626
Receptor tyrosine-protein kinase erbB-3 (ERBB3) Tyr protein kinase family P21860
Receptor tyrosine-protein kinase erbB-4 (ERBB4) Tyr protein kinase family Q15303
Focal adhesion kinase 1 (PTK2) Tyr protein kinase family Q05397
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Tyrosine-protein kinase Fgr (FGR) Tyr protein kinase family P09769
Tyrosine-protein kinase HCK (HCK) Tyr protein kinase family P08631
Tyrosine-protein kinase Lyn (LYN) Tyr protein kinase family P07948
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Tyrosine-protein kinase SYK (SYK) Tyr protein kinase family P43405
Tyrosine-protein kinase ZAP-70 (ZAP70) Tyr protein kinase family P43403
Tyrosine-protein phosphatase non-receptor type 1 (PTPN1) Protein-tyrosine phosphatase family P18031
Tyrosine-protein phosphatase non-receptor type 11 (PTPN11) Protein-tyrosine phosphatase family Q06124
Tyrosine-protein phosphatase non-receptor type 12 (PTPN12) Protein-tyrosine phosphatase family Q05209
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) Protein-tyrosine phosphatase family Q9Y2R2
Receptor-type tyrosine-protein phosphatase C (PTPRC) Protein-tyrosine phosphatase family P08575
Receptor-type tyrosine-protein phosphatase beta (PTPRB) Protein-tyrosine phosphatase family P23467
Receptor-type tyrosine-protein phosphatase H (PTPRH) Protein-tyrosine phosphatase family Q9HD43
Receptor-type tyrosine-protein phosphatase alpha (PTPRA) Protein-tyrosine phosphatase family P18433
Receptor-type tyrosine-protein phosphatase gamma (PTPRG) Protein-tyrosine phosphatase family P23470
Tensin-3 (TNS3) PTEN phosphatase protein family Q68CZ2
Thioredoxin (TXN) Thioredoxin family P10599
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Tubulin alpha-1A chain (TUBA1A) Tubulin family Q71U36
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-1 (PLCG1) . P19174
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2 (PLCG2) . P16885
E3 ubiquitin-protein ligase CBL (CBL) . P22681
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
E3 ubiquitin-protein ligase NEDD4 (NEDD4) . P46934
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) . Q13451
Peptidyl-prolyl cis-trans isomerase FKBP8 (FKBP8) . Q14318
TGF-beta-activated kinase 1 and MAP3K7-binding protein 1 (TAB1) . Q15750
Transporter and channel
Click To Hide/Show 26 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein theta (YWHAQ) 14-3-3 family P27348
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
AP-1 complex subunit beta-1 (AP1B1) Adaptor complexes large subunit family Q10567
AP-2 complex subunit mu (AP2M1) Adaptor complexes medium subunit family Q96CW1
Annexin A1 (ANXA1) Annexin family P04083
Annexin A2 (ANXA2) Annexin family P07355
Beclin-1 (BECN1) Beclin family Q14457
Catenin delta-1 (CTNND1) Beta-catenin family O60716
Caveolin-1 (CAV1) Caveolin family Q03135
Caveolin-2 (CAV2) Caveolin family P51636
Hsp90 co-chaperone Cdc37 (CDC37) CDC37 family Q16543
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Lysosomal-associated transmembrane protein 4B (LAPTM4B) LAPTM4/LAPTM5 transporter family Q86VI4
Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2) Ligand-gated ion channel family P47869
Protein OS-9 (OS9) OS-9 family Q13438
Exocyst complex component 4 (EXOC4) SEC8 family Q96A65
Protein transport protein Sec61 subunit alpha isoform 1 (SEC61A1) SecY/SEC61-alpha family P61619
Protein sel-1 homolog 1 (SEL1L) Sel-1 family Q9UBV2
Sodium/glucose cotransporter 1 (SLC5A1) Sodium:solute symporter (SSF) (TC 2.A.21) family P13866
Syntaxin-6 (STX6) Syntaxin family O43752
Toll-like receptor 2 (TLR2) Toll-like receptor family O60603
Vesicle-associated membrane protein-associated protein A (VAPA) VAMP-associated protein (VAP) (TC 9.B.17) family Q9P0L0
Cadherin-1 (CDH1) . P12830
Guided entry of tail-anchored proteins factor CAMLG (CAMLG) . P49069
Rab5 GDP/GTP exchange factor (RABGEF1) . Q9UJ41
Talin-1 (TLN1) . Q9Y490
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Estrogen receptor beta (ESR2) Nuclear hormone receptor family Q92731
Glucocorticoid receptor (NR3C1) Nuclear hormone receptor family P04150
Signal transducer and activator of transcription 1-alpha/beta (STAT1) Transcription factor STAT family P42224
Signal transducer and activator of transcription 3 (STAT3) Transcription factor STAT family P40763
Signal transducer and activator of transcription 5A (STAT5A) Transcription factor STAT family P42229
Immunoglobulin
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inactive tyrosine-protein kinase transmembrane receptor ROR1 (ROR1) Tyr protein kinase family Q01973
Advanced glycosylation end product-specific receptor (AGER) . Q15109
Leucine-rich repeat and immunoglobulin-like domain-containing nogo receptor-interacting protein 1 (LINGO1) . Q96FE5
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) . Q96JA1
Leucine-rich repeats and immunoglobulin-like domains protein 2 (LRIG2) . O94898
Other
Click To Hide/Show 69 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein sigma (SFN) 14-3-3 family P31947
Cofilin-1 (CFL1) Actin-binding proteins ADF family P23528
Gamma-aminobutyric acid receptor-associated protein-like 2 (GABARAPL2) ATG8 family P60520
Bcl-2-binding component 3, isoforms 1/2 (BBC3) Bcl-2 family Q9BXH1
Junction plakoglobin (JUP) Beta-catenin family P14923
Adapter molecule crk (CRK) CRK family P46108
Crk-like protein (CRKL) CRK family P46109
Docking protein 6 (DOK6) DOK family, Type B subfamily Q6PKX4
Epidermal growth factor receptor kinase substrate 8 (EPS8) EPS8 family Q12929
GRB2-associated-binding protein 1 (GAB1) GAB family Q13480
GRB2-associated-binding protein 2 (GAB2) GAB family Q9UQC2
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4
GRB2-related adapter protein 2 (GRAP2) GRB2/sem-5/DRK family O75791
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Growth factor receptor-bound protein 10 (GRB10) GRB7/10/14 family Q13322
Heat shock 70 kDa protein 4 (HSPA4) Heat shock protein 70 family P34932
Stress-70 protein, mitochondrial (HSPA9) Heat shock protein 70 family P38646
C-Jun-amino-terminal kinase-interacting protein 1 (MAPK8IP1) JIP scaffold family Q9UQF2
C-Jun-amino-terminal kinase-interacting protein 2 (MAPK8IP2) JIP scaffold family Q13387
ERBB receptor feedback inhibitor 1 (ERRFI1) MIG6 family Q9UJM3
Ras-associated and pleckstrin homology domains-containing protein 1 (RAPH1) MRL family Q70E73
Phosphatidylinositol 3-kinase regulatory subunit alpha (PIK3R1) PI3K p85 subunit family P27986
Phosphatidylinositol 3-kinase regulatory subunit beta (PIK3R2) PI3K p85 subunit family O00459
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3) PI3K p85 subunit family Q92569
Transmembrane glycoprotein NMB (GPNMB) PMEL/NMB family Q14956
Ras and Rab interactor 1 (RIN1) RIN (Ras interaction/interference) family Q13671
Protein S100-A4 (S100A4) S-100 family P26447
SH2B adapter protein 1 (SH2B1) SH2B adapter family Q9NRF2
SH2B adapter protein 3 (SH2B3) SH2B adapter family Q9UQQ2
TOM1-like protein 1 (TOM1L1) TOM1 family O75674
Tubulin beta-2A chain (TUBB2A) Tubulin family Q13885
A-kinase anchor protein 12 (AKAP12) . Q02952
AH receptor-interacting protein (AIP) . O00170
Amyloid beta precursor protein binding family B member 1 (APBB1) . O00213
Amyloid beta precursor protein binding family B member 2 (APBB2) . Q92870
Amyloid-beta A4 precursor protein-binding family B member 3 (APBB3) . O95704
Ankyrin repeat and SAM domain-containing protein 1A (ANKS1A) . Q92625
Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) . Q9UQB8
Cytokine-dependent hematopoietic cell linker (CLNK) . Q7Z7G1
Cytokine-inducible SH2-containing protein (CISH) . Q9NSE2
DCC-interacting protein 13-alpha (APPL1) . Q9UKG1
Epigen (EPGN) . Q6UW88
Ezrin (EZR) . P15311
Fanconi anemia group D2 protein (FANCD2) . Q9BXW9
Insulin receptor substrate 4 (IRS4) . O14654
Insulin-like growth factor-binding protein 3 (IGFBP3) . P17936
Intersectin-2 (ITSN2) . Q9NZM3
Linker for activation of T-cells family member 1 (LAT) . O43561
Lymphocyte cytosolic protein 2 (LCP2) . Q13094
Mucin-1 (MUC1) . P15941
Neuroblast differentiation-associated protein AHNAK (AHNAK) . Q09666
Numb-like protein (NUMBL) . Q9Y6R0
Pro-epidermal growth factor (EGF) . P01133
Proepiregulin (EREG) . O14944
Proheparin-binding EGF-like growth factor (HBEGF) . Q99075
Protein numb homolog (NUMB) . P49757
Protransforming growth factor alpha (TGFA) . P01135
Ras GTPase-activating protein 1 (RASA1) . P20936
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) . P46940
Run domain Beclin-1-interacting and cysteine-rich domain-containing protein (RUBCN) . Q92622
SH2 domain-containing protein 3A (SH2D3A) . Q9BRG2
SH2/SH3 adapter protein NCK1 (NCK1) . P16333
SHC-transforming protein 1 (SHC1) . P29353
SHC-transforming protein 2 (SHC2) . P98077
SHC-transforming protein 4 (SHC4) . Q6S5L8
Son of sevenless homolog 1 (SOS1) . Q07889
Src substrate cortactin (CTTN) . Q14247
Src-like-adapter (SLA) . Q13239
Stress-induced-phosphoprotein 1 (STIP1) . P31948

The Drug(s) Related To This Target

Approved
Click To Hide/Show 18 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amivantamab Antibody DB16695
Cetuximab Antibody DB00002
Necitumumab Monoclonal antibody DB09559
Panitumumab Monoclonal antibody DB01269
Afatinib Small molecular drug DB08916
Brigatinib Small molecular drug DB12267
Dacomitinib Small molecular drug DB11963
Erlotinib Small molecular drug DB00530
Fostamatinib Small molecular drug DB12010
Gefitinib Small molecular drug DB00317
Lapatinib Small molecular drug DB01259
Lidocaine Small molecular drug DB00281
Mobocertinib Small molecular drug DB16390
Neratinib Small molecular drug DB11828
Osimertinib Small molecular drug DB09330
Vandetanib Small molecular drug DB05294
Foreskin Keratinocyte (Neonatal) . DB10772
Zanubrutinib . DB15035
Phase 3
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Ac0010 . D0FV3K
Phase 2
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Egfr Antisense Dna Antisense drug D06VFF
Ck-101 . D09BZS
Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pyrotinib . D0M8YM
Investigative
Click To Hide/Show 16 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Matuzumab Antibody DB05101
Zalutumumab Antibody DB12202
Alvocidib Small molecular drug DB03496
Canertinib Small molecular drug DB05424
Pd-168393 Small molecular drug DB07662
Pelitinib Small molecular drug DB05524
Poziotinib Small molecular drug DB12114
Varlitinib Small molecular drug DB05944
Abivertinib . DB15327
Av-412 . DB06021
Depatuxizumab Mafodotin . DB11731
Icotinib . DB11737
Ign311 . DB04988
Olmutinib . DB13164
Rindopepimut . DB05374
S-{3-[(4-anilinoquinazolin-6-yl)Amino]-3-oxopropyl}-l-cysteine . DB07602

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
6 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
17 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
20 Affinity-based probes based on type II kinase inhibitors. J Am Chem Soc. 2012 Nov 21;134(46):19017-25. doi: 10.1021/ja306035v. Epub 2012 Nov 6.
21 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
22 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840