Details of the Target

General Information of Target

Target ID LDTP02302
Target Name Small ribosomal subunit protein eS17 (RPS17)
Gene Name RPS17
Gene ID 6218
Synonyms
RPS17L; Small ribosomal subunit protein eS17; 40S ribosomal protein S17
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MGRVRTKTVKKAARVIIEKYYTRLGNDFHTNKRVCEEIAIIPSKKLRNKIAGYVTHLMKR
IQRGPVRGISIKLQEEERERRDNYVPEVSALDQEIIEVDPDTKEMLKLLDFGSLSNLQVT
QPTVGMNFKTPRGPV
Target Bioclass
Other
Family
Eukaryotic ribosomal protein eS17 family
Subcellular location
Cytoplasm
Function
Component of the small ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome.
Uniprot ID
P08708
Ensemble ID
ENST00000617731.2
HGNC ID
HGNC:10397

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 45 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CY4
 Probe Info  		100.00  LDD0244  [1]
N1
 Probe Info  		100.00  LDD0242  [1]
TH211
 Probe Info  		Y20(10.03)  LDD0257  [2]
TH214
 Probe Info  		Y53(20.00)  LDD0258  [2]
TH216
 Probe Info  		Y53(10.99); Y20(8.19)  LDD0259  [2]
STPyne
 Probe Info  		K19(4.41); K32(2.44); K59(2.86)  LDD0277  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [3]
AF-1
 Probe Info  		1.71  LDD0421  [4]
AF-2
 Probe Info  		10.00  LDD0422  [4]
Alkyne-RA190
 Probe Info  		2.44  LDD0299  [5]
DBIA
 Probe Info  		C35(15.35)  LDD0209  [6]
HHS-465
 Probe Info  		Y53(5.89)  LDD2237  [7]
ATP probe
 Probe Info  		K32(0.00); K44(0.00); K45(0.00); K19(0.00)  LDD0199  [8]
CY-1
 Probe Info  		D82(0.00); E87(0.00); Y84(0.00); N83(0.00)  LDD0246  [1]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [10]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [11]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [11]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [9]
ATP probe
 Probe Info  		K129(0.00); K49(0.00); K19(0.00)  LDD0035  [12]
BTD
 Probe Info  		N.A.  LDD0004  [13]
IPM
 Probe Info  		N.A.  LDD0025  [14]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [14]
NAIA_4
 Probe Info  		N.A.  LDD2226  [15]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneC
 Probe Info  		N.A.  LDD0014  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [16]
Compound 11
 Probe Info  		N.A.  LDD2213  [16]
ENE
 Probe Info  		N.A.  LDD0006  [13]
NHS
 Probe Info  		K129(0.00); K72(0.00); K19(0.00)  LDD0010  [13]
PF-06672131
 Probe Info  		N.A.  LDD0152  [17]
SF
 Probe Info  		Y84(0.00); Y53(0.00); K19(0.00)  LDD0028  [18]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [19]
1c-yne
 Probe Info  		K72(0.00); K129(0.00); K103(0.00); K107(0.00)  LDD0228  [20]
Acrolein
 Probe Info  		C35(0.00); H29(0.00); H56(0.00)  LDD0217  [21]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [21]
Crotonaldehyde
 Probe Info  		C35(0.00); H56(0.00)  LDD0219  [21]
Methacrolein
 Probe Info  		N.A.  LDD0218  [21]
NAIA_5
 Probe Info  		N.A.  LDD2223  [15]
TER-AC
 Probe Info  		N.A.  LDD0426  [22]
TPP-AC
 Probe Info  		N.A.  LDD0427  [22]
HHS-475
 Probe Info  		Y53(1.21)  LDD2238  [7]
HHS-482
 Probe Info  		Y53(0.83); Y84(0.93)  LDD2239  [7]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [23]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C35(0.85)  LDD2142  [24]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C35(0.80)  LDD2112  [24]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C35(0.58)  LDD2095  [24]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C35(0.80)  LDD2130  [24]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C35(1.05)  LDD2117  [24]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C35(1.36)  LDD2152  [24]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C35(0.74)  LDD2103  [24]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C35(0.49)  LDD2132  [24]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C35(0.60)  LDD2131  [24]
 LDCM0214  AC1 HEK-293T C35(1.08)  LDD1507  [25]
 LDCM0215  AC10 HEK-293T C35(0.89)  LDD1508  [25]
 LDCM0226  AC11 HEK-293T C35(0.95)  LDD1509  [25]
 LDCM0237  AC12 HEK-293T C35(0.96)  LDD1510  [25]
 LDCM0259  AC14 HEK-293T C35(0.99)  LDD1512  [25]
 LDCM0270  AC15 HEK-293T C35(1.00)  LDD1513  [25]
 LDCM0276  AC17 HEK-293T C35(1.04)  LDD1515  [25]
 LDCM0277  AC18 HEK-293T C35(1.01)  LDD1516  [25]
 LDCM0278  AC19 HEK-293T C35(0.92)  LDD1517  [25]
 LDCM0279  AC2 HEK-293T C35(0.91)  LDD1518  [25]
 LDCM0280  AC20 HEK-293T C35(1.03)  LDD1519  [25]
 LDCM0281  AC21 HEK-293T C35(1.04)  LDD1520  [25]
 LDCM0282  AC22 HEK-293T C35(1.02)  LDD1521  [25]
 LDCM0283  AC23 HEK-293T C35(1.02)  LDD1522  [25]
 LDCM0284  AC24 HEK-293T C35(0.98)  LDD1523  [25]
 LDCM0285  AC25 HEK-293T C35(1.11)  LDD1524  [25]
 LDCM0286  AC26 HEK-293T C35(0.97)  LDD1525  [25]
 LDCM0287  AC27 HEK-293T C35(0.99)  LDD1526  [25]
 LDCM0288  AC28 HEK-293T C35(1.01)  LDD1527  [25]
 LDCM0289  AC29 HEK-293T C35(1.05)  LDD1528  [25]
 LDCM0290  AC3 HEK-293T C35(0.98)  LDD1529  [25]
 LDCM0291  AC30 HEK-293T C35(1.07)  LDD1530  [25]
 LDCM0292  AC31 HEK-293T C35(1.02)  LDD1531  [25]
 LDCM0293  AC32 HEK-293T C35(1.02)  LDD1532  [25]
 LDCM0294  AC33 HEK-293T C35(1.05)  LDD1533  [25]
 LDCM0295  AC34 HEK-293T C35(0.91)  LDD1534  [25]
 LDCM0296  AC35 HEK-293T C35(0.94)  LDD1535  [25]
 LDCM0297  AC36 HEK-293T C35(1.01)  LDD1536  [25]
 LDCM0298  AC37 HEK-293T C35(1.00)  LDD1537  [25]
 LDCM0299  AC38 HEK-293T C35(1.04)  LDD1538  [25]
 LDCM0300  AC39 HEK-293T C35(0.99)  LDD1539  [25]
 LDCM0301  AC4 HEK-293T C35(1.06)  LDD1540  [25]
 LDCM0302  AC40 HEK-293T C35(0.94)  LDD1541  [25]
 LDCM0303  AC41 HEK-293T C35(0.98)  LDD1542  [25]
 LDCM0304  AC42 HEK-293T C35(0.85)  LDD1543  [25]
 LDCM0305  AC43 HEK-293T C35(0.93)  LDD1544  [25]
 LDCM0306  AC44 HEK-293T C35(1.00)  LDD1545  [25]
 LDCM0307  AC45 HEK-293T C35(1.01)  LDD1546  [25]
 LDCM0308  AC46 HEK-293T C35(0.97)  LDD1547  [25]
 LDCM0309  AC47 HEK-293T C35(0.98)  LDD1548  [25]
 LDCM0310  AC48 HEK-293T C35(0.92)  LDD1549  [25]
 LDCM0311  AC49 HEK-293T C35(1.05)  LDD1550  [25]
 LDCM0312  AC5 HEK-293T C35(1.10)  LDD1551  [25]
 LDCM0313  AC50 HEK-293T C35(0.96)  LDD1552  [25]
 LDCM0314  AC51 HEK-293T C35(0.95)  LDD1553  [25]
 LDCM0315  AC52 HEK-293T C35(0.99)  LDD1554  [25]
 LDCM0316  AC53 HEK-293T C35(1.01)  LDD1555  [25]
 LDCM0317  AC54 HEK-293T C35(1.04)  LDD1556  [25]
 LDCM0318  AC55 HEK-293T C35(0.97)  LDD1557  [25]
 LDCM0319  AC56 HEK-293T C35(0.94)  LDD1558  [25]
 LDCM0320  AC57 HEK-293T C35(0.99)  LDD1559  [25]
 LDCM0321  AC58 HEK-293T C35(0.98)  LDD1560  [25]
 LDCM0322  AC59 HEK-293T C35(0.95)  LDD1561  [25]
 LDCM0323  AC6 HEK-293T C35(1.05)  LDD1562  [25]
 LDCM0324  AC60 HEK-293T C35(0.99)  LDD1563  [25]
 LDCM0325  AC61 HEK-293T C35(1.03)  LDD1564  [25]
 LDCM0326  AC62 HEK-293T C35(1.06)  LDD1565  [25]
 LDCM0327  AC63 HEK-293T C35(0.98)  LDD1566  [25]
 LDCM0328  AC64 HEK-293T C35(0.99)  LDD1567  [25]
 LDCM0334  AC7 HEK-293T C35(1.04)  LDD1568  [25]
 LDCM0345  AC8 HEK-293T C35(1.00)  LDD1569  [25]
 LDCM0166  Afatinib A431 1.71  LDD0421  [4]
 LDCM0520  AKOS000195272 MDA-MB-231 C35(0.66)  LDD2113  [24]
 LDCM0248  AKOS034007472 HEK-293T C35(1.01)  LDD1511  [25]
 LDCM0356  AKOS034007680 HEK-293T C35(1.04)  LDD1570  [25]
 LDCM0275  AKOS034007705 HEK-293T C35(0.97)  LDD1514  [25]
 LDCM0498  BS-3668 MDA-MB-231 C35(0.79)  LDD2091  [24]
 LDCM0108  Chloroacetamide HeLa H29(0.00); C35(0.00); H56(0.00)  LDD0222  [21]
 LDCM0632  CL-Sc Hep-G2 C35(1.01); C35(1.00); C35(0.49); C35(0.41)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C35(1.22)  LDD1571  [25]
 LDCM0368  CL10 HEK-293T C35(0.77)  LDD1572  [25]
 LDCM0369  CL100 HEK-293T C35(1.06)  LDD1573  [25]
 LDCM0370  CL101 HEK-293T C35(1.13)  LDD1574  [25]
 LDCM0371  CL102 HEK-293T C35(1.13)  LDD1575  [25]
 LDCM0372  CL103 HEK-293T C35(1.10)  LDD1576  [25]
 LDCM0373  CL104 HEK-293T C35(1.05)  LDD1577  [25]
 LDCM0374  CL105 HEK-293T C35(1.07)  LDD1578  [25]
 LDCM0375  CL106 HEK-293T C35(1.07)  LDD1579  [25]
 LDCM0376  CL107 HEK-293T C35(1.12)  LDD1580  [25]
 LDCM0377  CL108 HEK-293T C35(1.08)  LDD1581  [25]
 LDCM0378  CL109 HEK-293T C35(1.09)  LDD1582  [25]
 LDCM0379  CL11 HEK-293T C35(0.77)  LDD1583  [25]
 LDCM0380  CL110 HEK-293T C35(1.05)  LDD1584  [25]
 LDCM0381  CL111 HEK-293T C35(1.11)  LDD1585  [25]
 LDCM0382  CL112 HEK-293T C35(1.03)  LDD1586  [25]
 LDCM0383  CL113 HEK-293T C35(1.09)  LDD1587  [25]
 LDCM0384  CL114 HEK-293T C35(1.10)  LDD1588  [25]
 LDCM0385  CL115 HEK-293T C35(1.07)  LDD1589  [25]
 LDCM0386  CL116 HEK-293T C35(1.06)  LDD1590  [25]
 LDCM0387  CL117 HEK-293T C35(1.05)  LDD1591  [25]
 LDCM0388  CL118 HEK-293T C35(1.10)  LDD1592  [25]
 LDCM0389  CL119 HEK-293T C35(1.00)  LDD1593  [25]
 LDCM0390  CL12 HEK-293T C35(0.90)  LDD1594  [25]
 LDCM0391  CL120 HEK-293T C35(1.02)  LDD1595  [25]
 LDCM0392  CL121 HEK-293T C35(1.13)  LDD1596  [25]
 LDCM0393  CL122 HEK-293T C35(1.08)  LDD1597  [25]
 LDCM0394  CL123 HEK-293T C35(0.98)  LDD1598  [25]
 LDCM0395  CL124 HEK-293T C35(1.01)  LDD1599  [25]
 LDCM0396  CL125 HEK-293T C35(1.57)  LDD1600  [25]
 LDCM0397  CL126 HEK-293T C35(1.19)  LDD1601  [25]
 LDCM0398  CL127 HEK-293T C35(1.23)  LDD1602  [25]
 LDCM0399  CL128 HEK-293T C35(1.16)  LDD1603  [25]
 LDCM0400  CL13 HEK-293T C35(1.21)  LDD1604  [25]
 LDCM0401  CL14 HEK-293T C35(1.16)  LDD1605  [25]
 LDCM0402  CL15 HEK-293T C35(1.03)  LDD1606  [25]
 LDCM0403  CL16 HEK-293T C35(1.00)  LDD1607  [25]
 LDCM0404  CL17 HEK-293T C35(0.88)  LDD1608  [25]
 LDCM0405  CL18 HEK-293T C35(0.93)  LDD1609  [25]
 LDCM0406  CL19 HEK-293T C35(0.94)  LDD1610  [25]
 LDCM0407  CL2 HEK-293T C35(1.18)  LDD1611  [25]
 LDCM0408  CL20 HEK-293T C35(0.89)  LDD1612  [25]
 LDCM0409  CL21 HEK-293T C35(0.91)  LDD1613  [25]
 LDCM0410  CL22 HEK-293T C35(0.84)  LDD1614  [25]
 LDCM0411  CL23 HEK-293T C35(0.75)  LDD1615  [25]
 LDCM0412  CL24 HEK-293T C35(0.90)  LDD1616  [25]
 LDCM0413  CL25 HEK-293T C35(1.43)  LDD1617  [25]
 LDCM0414  CL26 HEK-293T C35(1.25)  LDD1618  [25]
 LDCM0415  CL27 HEK-293T C35(1.08)  LDD1619  [25]
 LDCM0416  CL28 HEK-293T C35(1.02)  LDD1620  [25]
 LDCM0417  CL29 HEK-293T C35(1.08)  LDD1621  [25]
 LDCM0418  CL3 HEK-293T C35(1.17)  LDD1622  [25]
 LDCM0419  CL30 HEK-293T C35(0.99)  LDD1623  [25]
 LDCM0420  CL31 HEK-293T C35(0.91)  LDD1624  [25]
 LDCM0421  CL32 HEK-293T C35(0.93)  LDD1625  [25]
 LDCM0422  CL33 HEK-293T C35(0.84)  LDD1626  [25]
 LDCM0423  CL34 HEK-293T C35(0.79)  LDD1627  [25]
 LDCM0424  CL35 HEK-293T C35(0.74)  LDD1628  [25]
 LDCM0425  CL36 HEK-293T C35(0.89)  LDD1629  [25]
 LDCM0426  CL37 HEK-293T C35(1.58)  LDD1630  [25]
 LDCM0428  CL39 HEK-293T C35(1.04)  LDD1632  [25]
 LDCM0429  CL4 HEK-293T C35(1.04)  LDD1633  [25]
 LDCM0430  CL40 HEK-293T C35(1.02)  LDD1634  [25]
 LDCM0431  CL41 HEK-293T C35(0.99)  LDD1635  [25]
 LDCM0432  CL42 HEK-293T C35(1.09)  LDD1636  [25]
 LDCM0433  CL43 HEK-293T C35(0.97)  LDD1637  [25]
 LDCM0434  CL44 HEK-293T C35(0.92)  LDD1638  [25]
 LDCM0435  CL45 HEK-293T C35(0.91)  LDD1639  [25]
 LDCM0436  CL46 HEK-293T C35(0.80)  LDD1640  [25]
 LDCM0437  CL47 HEK-293T C35(0.77)  LDD1641  [25]
 LDCM0438  CL48 HEK-293T C35(0.92)  LDD1642  [25]
 LDCM0439  CL49 HEK-293T C35(1.54)  LDD1643  [25]
 LDCM0440  CL5 HEK-293T C35(1.00)  LDD1644  [25]
 LDCM0441  CL50 HEK-293T C35(1.13)  LDD1645  [25]
 LDCM0443  CL52 HEK-293T C35(1.00)  LDD1646  [25]
 LDCM0444  CL53 HEK-293T C35(0.87)  LDD1647  [25]
 LDCM0445  CL54 HEK-293T C35(0.85)  LDD1648  [25]
 LDCM0446  CL55 HEK-293T C35(0.93)  LDD1649  [25]
 LDCM0447  CL56 HEK-293T C35(0.88)  LDD1650  [25]
 LDCM0448  CL57 HEK-293T C35(0.91)  LDD1651  [25]
 LDCM0449  CL58 HEK-293T C35(0.80)  LDD1652  [25]
 LDCM0450  CL59 HEK-293T C35(0.77)  LDD1653  [25]
 LDCM0451  CL6 HEK-293T C35(0.92)  LDD1654  [25]
 LDCM0452  CL60 HEK-293T C35(0.86)  LDD1655  [25]
 LDCM0453  CL61 HEK-293T C35(1.67)  LDD1656  [25]
 LDCM0454  CL62 HEK-293T C35(1.23)  LDD1657  [25]
 LDCM0455  CL63 HEK-293T C35(1.10)  LDD1658  [25]
 LDCM0456  CL64 HEK-293T C35(0.96)  LDD1659  [25]
 LDCM0457  CL65 HEK-293T C35(1.01)  LDD1660  [25]
 LDCM0458  CL66 HEK-293T C35(0.92)  LDD1661  [25]
 LDCM0459  CL67 HEK-293T C35(0.95)  LDD1662  [25]
 LDCM0460  CL68 HEK-293T C35(0.90)  LDD1663  [25]
 LDCM0461  CL69 HEK-293T C35(0.93)  LDD1664  [25]
 LDCM0462  CL7 HEK-293T C35(0.97)  LDD1665  [25]
 LDCM0463  CL70 HEK-293T C35(0.82)  LDD1666  [25]
 LDCM0464  CL71 HEK-293T C35(0.78)  LDD1667  [25]
 LDCM0465  CL72 HEK-293T C35(0.91)  LDD1668  [25]
 LDCM0466  CL73 HEK-293T C35(1.49)  LDD1669  [25]
 LDCM0467  CL74 HEK-293T C35(1.30)  LDD1670  [25]
 LDCM0469  CL76 HEK-293T C35(1.06)  LDD1672  [25]
 LDCM0470  CL77 HEK-293T C35(0.95)  LDD1673  [25]
 LDCM0471  CL78 HEK-293T C35(0.97)  LDD1674  [25]
 LDCM0472  CL79 HEK-293T C35(0.97)  LDD1675  [25]
 LDCM0473  CL8 HEK-293T C35(0.71)  LDD1676  [25]
 LDCM0474  CL80 HEK-293T C35(0.99)  LDD1677  [25]
 LDCM0475  CL81 HEK-293T C35(0.95)  LDD1678  [25]
 LDCM0476  CL82 HEK-293T C35(0.86)  LDD1679  [25]
 LDCM0477  CL83 HEK-293T C35(0.81)  LDD1680  [25]
 LDCM0478  CL84 HEK-293T C35(0.97)  LDD1681  [25]
 LDCM0479  CL85 HEK-293T C35(2.36)  LDD1682  [25]
 LDCM0480  CL86 HEK-293T C35(1.65)  LDD1683  [25]
 LDCM0481  CL87 HEK-293T C35(1.28)  LDD1684  [25]
 LDCM0482  CL88 HEK-293T C35(1.24)  LDD1685  [25]
 LDCM0483  CL89 HEK-293T C35(1.14)  LDD1686  [25]
 LDCM0484  CL9 HEK-293T C35(1.01)  LDD1687  [25]
 LDCM0485  CL90 HEK-293T C35(0.77)  LDD1688  [25]
 LDCM0486  CL91 HEK-293T C35(1.04)  LDD1689  [25]
 LDCM0487  CL92 HEK-293T C35(0.95)  LDD1690  [25]
 LDCM0488  CL93 HEK-293T C35(0.96)  LDD1691  [25]
 LDCM0489  CL94 HEK-293T C35(0.91)  LDD1692  [25]
 LDCM0490  CL95 HEK-293T C35(0.77)  LDD1693  [25]
 LDCM0491  CL96 HEK-293T C35(1.05)  LDD1694  [25]
 LDCM0492  CL97 HEK-293T C35(1.24)  LDD1695  [25]
 LDCM0493  CL98 HEK-293T C35(1.15)  LDD1696  [25]
 LDCM0494  CL99 HEK-293T C35(1.07)  LDD1697  [25]
 LDCM0495  E2913 HEK-293T C35(1.04)  LDD1698  [25]
 LDCM0468  Fragment33 HEK-293T C35(1.11)  LDD1671  [25]
 LDCM0427  Fragment51 HEK-293T C35(1.16)  LDD1631  [25]
 LDCM0107  IAA HeLa H29(0.00); H56(0.00); C35(0.00)  LDD0221  [21]
 LDCM0022  KB02 HEK-293T C35(1.04)  LDD1492  [25]
 LDCM0023  KB03 Jurkat C35(15.35)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C35(3.54)  LDD3310  [26]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C35(1.21)  LDD2121  [24]
 LDCM0109  NEM HeLa H29(0.00); H56(0.00)  LDD0223  [21]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C35(0.81)  LDD2089  [24]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C35(0.94)  LDD2092  [24]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C35(1.07)  LDD2093  [24]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C35(1.03)  LDD2094  [24]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C35(0.81)  LDD2097  [24]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C35(0.85)  LDD2098  [24]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C35(1.00)  LDD2099  [24]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C35(0.60)  LDD2101  [24]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C35(0.61)  LDD2104  [24]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C35(1.10)  LDD2105  [24]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C35(0.64)  LDD2106  [24]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C35(1.17)  LDD2107  [24]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C35(0.67)  LDD2109  [24]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C35(0.86)  LDD2110  [24]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C35(1.03)  LDD2111  [24]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C35(0.58)  LDD2114  [24]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C35(0.37)  LDD2115  [24]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C35(0.87)  LDD2116  [24]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C35(0.41)  LDD2118  [24]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C35(2.00)  LDD2119  [24]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C35(0.78)  LDD2120  [24]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C35(0.84)  LDD2123  [24]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C35(0.81)  LDD2125  [24]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C35(1.02)  LDD2127  [24]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C35(0.78)  LDD2128  [24]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C35(1.39)  LDD2129  [24]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C35(0.51)  LDD2133  [24]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C35(0.50)  LDD2134  [24]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C35(1.63)  LDD2135  [24]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C35(1.19)  LDD2136  [24]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C35(0.94)  LDD2137  [24]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C35(1.65)  LDD1700  [24]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C35(0.80)  LDD2140  [24]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C35(0.69)  LDD2141  [24]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C35(0.88)  LDD2143  [24]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C35(6.22)  LDD2145  [24]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C35(0.91)  LDD2146  [24]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C35(1.60)  LDD2147  [24]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C35(0.28)  LDD2148  [24]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C35(0.57)  LDD2150  [24]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C35(1.52)  LDD2153  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C35(1.01)  LDD2207  [27]
 LDCM0131  RA190 MM1.R 2.44  LDD0299  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Minimalist linkers suitable for irreversible inhibitors in simultaneous proteome profiling, live-cell imaging and drug screening. Chem Commun (Camb). 2019 Jan 15;55(6):834-837. doi: 10.1039/c8cc08685k.
5 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
12 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
18 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
19 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
22 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
25 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.