Details of the Target

General Information of Target

Target ID LDTP03512
Target Name Peroxiredoxin-5, mitochondrial (PRDX5)
Gene Name PRDX5
Gene ID 25824
Synonyms
ACR1; Peroxiredoxin-5, mitochondrial; EC 1.11.1.24; Alu corepressor 1; Antioxidant enzyme B166; AOEB166; Liver tissue 2D-page spot 71B; PLP; Peroxiredoxin V; Prx-V; Peroxisomal antioxidant enzyme; TPx type VI; Thioredoxin peroxidase PMP20; Thioredoxin-dependent peroxiredoxin 5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGLAGVCALRRSAGYILVGGAGGQSAAAAARRYSEGEWASGGVRSFSRAAAAMAPIKVGD
AIPAVEVFEGEPGNKVNLAELFKGKKGVLFGVPGAFTPGCSKTHLPGFVEQAEALKAKGV
QVVACLSVNDAFVTGEWGRAHKAEGKVRLLADPTGAFGKETDLLLDDSLVSIFGNRRLKR
FSMVVQDGIVKALNVEPDGTGLTCSLAPNIISQL
Target Type
Successful
Target Bioclass
Enzyme
Family
Peroxiredoxin family, Prx5 subfamily
Subcellular location
Cytoplasm; Mitochondrion
Function
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events.
TTD ID
T77009
Uniprot ID
P30044
DrugMap ID
TTLPJWH
Ensemble ID
ENST00000265462.9
HGNC ID
HGNC:9355
ChEMBL ID
CHEMBL3627586

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCC1395 SNV: p.F157L DBIA    Probe Info 
LNCaP clone FGC SNV: p.S171F DBIA    Probe Info 
SW1573 SNV: p.K159N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.51  LDD0402  [1]
SAA-alkyne
 Probe Info  		1.07  LDD0252  [2]
FBP2
 Probe Info  		2.11  LDD0323  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
STPyne
 Probe Info  		K102(1.09); K116(6.02); K118(1.89); K146(7.23)  LDD0277  [5]
AZ-9
 Probe Info  		E110(1.51); E80(1.17)  LDD2208  [6]
OPA-S-S-alkyne
 Probe Info  		K146(1.62); K142(1.62)  LDD3494  [7]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [8]
BTD
 Probe Info  		C100(0.51)  LDD2089  [9]
AHL-Pu-1
 Probe Info  		C13(3.31)  LDD0170  [10]
Alkyne-RA190
 Probe Info  		2.85  LDD0300  [11]
EA-probe
 Probe Info  		C100(1.46)  LDD2210  [12]
DBIA
 Probe Info  		C100(0.91)  LDD0078  [13]
5E-2FA
 Probe Info  		N.A.  LDD2235  [14]
ATP probe
 Probe Info  		K102(0.00); K86(0.00)  LDD0199  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C204(0.00); C100(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
Lodoacetamide azide
 Probe Info  		C204(0.00); C100(0.00)  LDD0037  [16]
ATP probe
 Probe Info  		K86(0.00); K116(0.00)  LDD0035  [18]
JW-RF-010
 Probe Info  		C100(0.00); C204(0.00)  LDD0026  [19]
NAIA_4
 Probe Info  		C100(0.00); 0.00  LDD2226  [20]
TFBX
 Probe Info  		C204(0.00); C100(0.00)  LDD0027  [19]
WYneN
 Probe Info  		N.A.  LDD0021  [21]
WYneO
 Probe Info  		N.A.  LDD0022  [21]
Compound 10
 Probe Info  		N.A.  LDD2216  [22]
Compound 11
 Probe Info  		N.A.  LDD2213  [22]
IPM
 Probe Info  		N.A.  LDD0005  [21]
NHS
 Probe Info  		N.A.  LDD0010  [21]
PF-06672131
 Probe Info  		N.A.  LDD0017  [23]
Phosphinate-6
 Probe Info  		C204(0.00); C100(0.00)  LDD0018  [24]
1c-yne
 Probe Info  		K86(0.00); K102(0.00); K75(0.00)  LDD0228  [25]
1d-yne
 Probe Info  		K116(0.00); K57(0.00)  LDD0357  [25]
Acrolein
 Probe Info  		H104(0.00); C100(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [26]
Methacrolein
 Probe Info  		N.A.  LDD0218  [26]
W1
 Probe Info  		N.A.  LDD0236  [27]
AOyne
 Probe Info  		7.10  LDD0443  [28]
NAIA_5
 Probe Info  		C204(0.00); C100(0.00); C125(0.00)  LDD2223  [20]
HHS-465
 Probe Info  		K86(0.00); K142(0.00)  LDD2240  [29]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.13  LDD0475  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C13(3.31)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA DM93 C13(2.92)  LDD0171  [10]
 LDCM0214  AC1 HCT 116 C100(0.99); C204(0.79)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C100(1.14); C204(1.01)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C100(0.86)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C100(0.97)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C100(0.88)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C100(0.89)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C100(0.93)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C100(1.05)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C100(0.90)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C100(1.02)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C100(0.88)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C100(0.97)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C100(1.09); C204(0.94)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C100(0.84)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C100(0.87)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C100(1.23)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C100(0.99); C204(1.16)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C100(0.98); C204(1.02)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C100(0.99); C204(1.05)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C100(1.05); C204(1.30)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C100(0.96); C204(1.12)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C100(1.01); C204(1.05)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C100(0.92); C204(0.86)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C100(1.09); C204(0.87)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C100(1.03); C204(1.12)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C100(0.99); C204(1.07)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C100(0.96); C204(0.99)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C100(0.84); C204(1.09)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C100(0.95); C204(0.99)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C100(1.01); C204(1.11)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C100(1.00); C204(1.15)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C100(1.12); C204(1.01)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C100(1.04); C204(0.95)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C100(0.79); C204(0.97)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C100(0.94); C204(0.87)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C100(0.84); C204(1.09)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C100(0.85); C204(0.68)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C100(0.85); C204(0.79)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C100(0.93); C204(0.83)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C100(0.96); C204(0.84)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C100(0.92); C204(0.86)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C100(0.98); C204(0.65)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C100(1.00); C204(0.87)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C100(0.87); C204(0.80)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C100(1.01); C204(0.83)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C100(0.93); C204(0.79)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C100(0.93); C204(0.73)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C100(0.94); C204(0.69)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C204(0.92); C100(1.36)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C204(1.06); C100(1.17)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C204(0.97); C100(1.08)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C204(0.93); C100(1.08)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C204(0.99); C100(1.04)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C100(1.38); C204(1.47)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C204(1.00); C100(1.05)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C204(0.91); C100(1.07)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C204(0.93); C100(1.10)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C204(1.08); C100(1.09)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C204(1.14); C100(1.23)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C100(1.41); C204(1.47)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C100(1.12); C204(1.09)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C100(1.28); C204(1.06)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C100(0.95); C204(1.11)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C100(0.97); C204(1.31)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C204(0.93); C100(0.98)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C204(0.98); C100(0.99)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C100(0.99); C204(1.24)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C204(0.92); C100(0.93)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C100(1.01); C204(1.06)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C100(0.97); C204(1.01)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C204(0.99); C100(1.03)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C204(0.80); C100(1.09)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C100(0.98); C204(1.31)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C204(0.93); C100(1.14)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C204(0.92); C100(1.19)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C100(1.07); C204(1.31)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C204(1.03); C100(1.20)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C204(0.95); C100(1.08)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C204(0.87); C100(0.91)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C204(1.11); C100(1.12)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C204(1.09); C100(1.10)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C204(1.02); C100(1.28)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C204(1.18); C100(1.22)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C204(1.07); C100(1.21)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C100(1.02)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C100(1.04)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C100(1.00)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C100(0.97)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C100(1.10)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C204(0.98); C100(1.00)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C100(1.15)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C100(1.16)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C100(1.05)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C100(1.06)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C100(1.07)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C100(1.17)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C100(0.92)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C100(1.01)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C100(1.02)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C100(1.19)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C204(0.88); C100(1.03)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C100(1.10)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C100(0.92)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C100(1.04)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C100(1.05)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C100(1.08)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C100(1.17)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C100(1.20)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C100(1.16); C204(1.52)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C100(1.01); C204(1.75)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C100(1.19); C204(1.21)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C204(0.96); C100(1.16)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C100(1.06); C204(1.61)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C100(1.18); C204(2.02)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C100(1.27); C204(1.59)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C100(1.21); C204(1.88)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C100(1.19); C204(1.33)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C100(1.20); C204(3.52)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C100(1.16); C204(2.15)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C100(1.16); C204(1.57)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C204(0.94); C100(1.07)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C204(1.00); C100(1.04)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C204(0.96); C100(1.09)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C204(0.91); C100(0.92)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C204(0.81); C100(0.98)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C100(0.96); C204(1.07)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C100(1.11); C204(1.52)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C100(1.01); C204(1.32)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C100(1.15); C204(1.49)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C100(0.98); C204(1.01)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C100(1.04); C204(1.10)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C100(1.00); C204(1.03)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C204(0.94); C100(0.95)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C204(0.95); C100(1.13)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C100(0.97); C204(1.05)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C204(0.95); C100(1.10)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C100(0.89); C204(1.21)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C100(1.21)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C100(1.09)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C100(1.03)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C100(0.93)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C100(0.87)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C100(0.87)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C100(0.98)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C100(0.98)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C100(1.19)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C100(1.15)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C100(0.98)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C100(1.00)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C100(0.98)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C100(0.98)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C100(1.08)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C100(0.81)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C100(1.00)  LDD0683  [13]
 LDCM0248  AKOS034007472 HCT 116 C100(1.03); C204(0.86)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C204(1.03); C100(1.17)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C204(1.26); C100(1.31)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 12.09  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C100(0.91)  LDD0078  [13]
 LDCM0108  Chloroacetamide HeLa C100(0.00); H104(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C204(20.00); C100(1.99); C100(0.64)  LDD2227  [20]
 LDCM0367  CL1 HCT 116 C100(0.84)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C100(0.98)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C204(0.99); C100(1.04)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C204(1.07); C100(1.12)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C100(1.00); C204(1.04)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C100(0.80); C204(0.87)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C100(1.01); C204(1.02)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C204(0.89); C100(1.01)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C100(1.06); C204(1.24)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C204(1.08); C100(1.18)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C100(1.14); C204(1.25)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C100(0.99); C204(1.05)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C100(1.09)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C100(0.93); C204(0.96)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C100(0.97); C204(1.05)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C204(0.80); C100(1.01)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C204(1.15); C100(1.22)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C204(0.74); C100(1.05)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C100(1.09); C204(1.22)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C204(1.09); C100(1.25)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C100(1.31)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C100(1.09)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C100(1.03)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C100(1.20)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C100(0.97)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C100(0.99)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C100(1.05)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C100(0.94)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C100(1.13)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C100(1.08); C204(1.26)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C100(1.03); C204(1.08)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C100(1.00); C204(1.19)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C100(1.08); C204(1.66)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C100(1.05)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C100(0.90)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C100(1.04)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C100(1.25); C204(1.36)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C100(1.02); C204(1.08)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C100(1.34); C204(1.67)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C100(1.25); C204(1.54)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C100(0.92)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C100(1.31); C204(1.61)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C100(1.18); C204(1.52)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C100(1.49); C204(2.10)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C100(1.25); C204(1.42)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C100(1.45); C204(1.80)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C100(1.38); C204(1.51)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C100(1.30); C204(1.16)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C100(1.28); C204(1.22)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C100(1.25); C204(1.47)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C100(1.32); C204(1.59)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C100(0.92)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C100(1.24); C204(1.34)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C100(0.98)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C100(1.09)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C100(0.86)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C100(1.15)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C100(1.15)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C100(1.04)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C100(1.09)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C100(1.16)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C100(0.87)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C100(1.00)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C100(1.09)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C100(1.51)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C100(1.24)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C100(1.05)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C100(1.16)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C100(0.97); C204(1.05)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C100(0.94); C204(1.01)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C100(0.92); C204(0.92)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C100(1.00); C204(1.21)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C100(0.99)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C100(0.98); C204(1.24)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C100(0.90); C204(0.95)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C100(0.86); C204(0.95)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C100(0.91); C204(1.13)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C100(0.89); C204(1.02)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C100(0.92); C204(1.10)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C100(1.05); C204(1.10)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C100(0.87); C204(0.98)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C100(1.03); C204(1.22)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C100(1.13); C204(1.10)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C100(0.91)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C100(1.05); C204(1.38)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C100(1.15); C204(0.86)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C100(1.07); C204(0.84)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C100(1.04); C204(0.83)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C100(1.20); C204(1.05)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C100(1.06); C204(1.22)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C100(1.19); C204(1.10)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C100(1.30); C204(1.31)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C100(1.15); C204(0.90)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C100(1.12); C204(1.21)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C100(1.12)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C100(1.16); C204(1.17)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C100(1.13); C204(1.04)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C100(1.32); C204(0.89)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C100(0.97); C204(0.99)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C100(1.14); C204(1.00)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C100(0.97); C204(0.99)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C100(1.00); C204(1.02)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C100(1.02); C204(0.98)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C100(1.08); C204(1.30)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C100(1.15)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C100(0.97); C204(1.06)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C100(1.03); C204(1.13)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C100(1.11); C204(1.54)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C100(1.08); C204(1.31)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C100(1.11); C204(1.43)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C100(1.01); C204(0.96)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C100(1.04); C204(0.95)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C100(1.03); C204(1.02)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C100(1.02); C204(1.09)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C100(1.15); C204(1.71)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C100(1.04)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C100(0.66); C204(0.72)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C100(0.94); C204(0.83)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C100(0.86); C204(0.67)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C100(0.90); C204(0.76)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C100(0.85); C204(0.80)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C100(0.81); C204(0.73)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C100(0.87); C204(0.81)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C100(0.93); C204(0.90)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C100(1.02); C204(0.94)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C100(1.02); C204(1.02)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C204(1.34)  LDD2228  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C100(0.88)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa C100(1.46)  LDD2210  [12]
 LDCM0625  F8 Ramos C100(1.33); C204(1.51)  LDD2187  [31]
 LDCM0572  Fragment10 MDA-MB-231 C204(2.52); C100(8.04)  LDD1389  [32]
 LDCM0573  Fragment11 MDA-MB-231 C204(2.53); C100(2.41)  LDD1391  [32]
 LDCM0574  Fragment12 MDA-MB-231 C204(1.81); C100(4.95)  LDD1393  [32]
 LDCM0575  Fragment13 MDA-MB-231 C204(0.83)  LDD1395  [32]
 LDCM0576  Fragment14 MDA-MB-231 C204(1.06); C100(0.77)  LDD1397  [32]
 LDCM0577  Fragment15 Ramos C204(1.00); C100(0.85)  LDD1400  [32]
 LDCM0579  Fragment20 MDA-MB-231 C204(1.55); C100(1.76)  LDD1402  [32]
 LDCM0580  Fragment21 MDA-MB-231 C204(1.13); C100(1.15)  LDD1404  [32]
 LDCM0581  Fragment22 MDA-MB-231 C204(0.88)  LDD1406  [32]
 LDCM0582  Fragment23 MDA-MB-231 C204(0.43); C100(0.29)  LDD1408  [32]
 LDCM0583  Fragment24 Ramos C204(0.90)  LDD1410  [32]
 LDCM0584  Fragment25 MDA-MB-231 C204(0.92)  LDD1411  [32]
 LDCM0585  Fragment26 Ramos C204(0.70); C100(0.50)  LDD1412  [32]
 LDCM0578  Fragment27 MDA-MB-231 C204(0.80); C100(0.86)  LDD1401  [32]
 LDCM0586  Fragment28 MDA-MB-231 C204(1.02); C100(1.06)  LDD1415  [32]
 LDCM0587  Fragment29 MDA-MB-231 C204(0.95); C100(0.91)  LDD1417  [32]
 LDCM0588  Fragment30 MDA-MB-231 C204(0.89)  LDD1419  [32]
 LDCM0589  Fragment31 MDA-MB-231 C204(1.21)  LDD1421  [32]
 LDCM0590  Fragment32 MDA-MB-231 C204(1.79); C100(6.82)  LDD1423  [32]
 LDCM0468  Fragment33 HCT 116 C100(1.11); C204(1.12)  LDD0785  [13]
 LDCM0592  Fragment34 Ramos C204(1.43)  LDD1428  [32]
 LDCM0593  Fragment35 MDA-MB-231 C204(0.87)  LDD1429  [32]
 LDCM0594  Fragment36 MDA-MB-231 C204(2.10)  LDD1431  [32]
 LDCM0595  Fragment37 Ramos C204(0.91)  LDD1432  [32]
 LDCM0596  Fragment38 MDA-MB-231 C204(1.00); C100(0.46)  LDD1433  [32]
 LDCM0597  Fragment39 MDA-MB-231 C204(1.05)  LDD1435  [32]
 LDCM0566  Fragment4 MDA-MB-231 C204(2.24); C100(1.05)  LDD1378  [32]
 LDCM0598  Fragment40 MDA-MB-231 C100(0.60)  LDD1436  [32]
 LDCM0599  Fragment41 MDA-MB-231 C100(0.69)  LDD1438  [32]
 LDCM0600  Fragment42 Ramos C204(0.80); C100(0.90)  LDD1440  [32]
 LDCM0601  Fragment43 MDA-MB-231 C204(2.12); C100(4.78)  LDD1441  [32]
 LDCM0602  Fragment44 MDA-MB-231 C204(0.65); C100(0.76)  LDD1443  [32]
 LDCM0603  Fragment45 MDA-MB-231 C204(2.95)  LDD1444  [32]
 LDCM0604  Fragment46 MDA-MB-231 C204(0.63); C100(0.43)  LDD1445  [32]
 LDCM0605  Fragment47 MDA-MB-231 C204(0.74); C100(0.83)  LDD1446  [32]
 LDCM0606  Fragment48 MDA-MB-231 C204(1.34)  LDD1447  [32]
 LDCM0607  Fragment49 MDA-MB-231 C204(0.98)  LDD1448  [32]
 LDCM0608  Fragment50 MDA-MB-231 C204(1.50)  LDD1449  [32]
 LDCM0427  Fragment51 HCT 116 C100(1.43)  LDD0744  [13]
 LDCM0610  Fragment52 MDA-MB-231 C204(0.72); C100(0.81)  LDD1452  [32]
 LDCM0611  Fragment53 MDA-MB-231 C204(0.64); C100(0.65)  LDD1454  [32]
 LDCM0612  Fragment54 MDA-MB-231 C204(1.06)  LDD1456  [32]
 LDCM0613  Fragment55 MDA-MB-231 C204(1.31)  LDD1457  [32]
 LDCM0614  Fragment56 MDA-MB-231 C204(0.90); C100(0.77)  LDD1458  [32]
 LDCM0568  Fragment6 MDA-MB-231 C100(1.11)  LDD1382  [32]
 LDCM0569  Fragment7 MDA-MB-231 C204(0.71)  LDD1383  [32]
 LDCM0570  Fragment8 MDA-MB-231 C204(1.12)  LDD1385  [32]
 LDCM0571  Fragment9 MDA-MB-231 C204(1.09); C100(1.06)  LDD1387  [32]
 LDCM0015  HNE MDA-MB-231 C100(0.78)  LDD0346  [31]
 LDCM0107  IAA HeLa H104(0.00); C100(0.00)  LDD0221  [26]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [8]
 LDCM0022  KB02 MDA-MB-231 C204(3.11); C100(3.31)  LDD1374  [32]
 LDCM0023  KB03 Jurkat C204(4.84)  LDD0315  [17]
 LDCM0024  KB05 G361 C204(1.91)  LDD3311  [33]
 LDCM0109  NEM HeLa N.A.  LDD0223  [26]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C100(0.51)  LDD2089  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C100(0.74)  LDD2092  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C100(1.08)  LDD2106  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C100(1.74)  LDD2110  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C100(1.06)  LDD2114  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C100(1.27)  LDD2124  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C204(1.15); C100(0.79)  LDD2206  [34]
 LDCM0628  OTUB2-COV-1 HEK-293T C100(0.83); C204(0.67)  LDD2207  [34]
 LDCM0131  RA190 MM1.R 2.85  LDD0300  [11]
 LDCM0021  THZ1 HCT 116 C100(0.92)  LDD2173  [13]
 LDCM0113  W17 Hep-G2 C100(2.32)  LDD0240  [27]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Superoxide dismutase [Cu-Zn] (SOD1) Cu-Zn superoxide dismutase family P00441
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclin-dependent kinase 4 inhibitor D (CDKN2D) CDKN2 cyclin-dependent kinase inhibitor family P55273
FMR1-interacting protein NUFIP2 (NUFIP2) . Q7Z417
Sperm mitochondrial-associated cysteine-rich protein (SMCP) . P49901

The Drug(s) Related To This Target

Approved
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Auranofin Small molecular drug DB00995
Motexafin Gadolinium Small molecular drug D05BJD
Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Eptacog Beta Small molecular drug DNXH76
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Diminazene Small molecular drug DB03608
Polaprezinc . DB09221
Patented
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Diterpene Triepoxide Derivative 1 Small molecular drug D0CF4R

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomics and Phosphoproteomics Profiling Reveals Salvianolic Acid A as a Covalent Inhibitor of mTORC1. J Proteome Res. 2023 Jul 7;22(7):2450-2459. doi: 10.1021/acs.jproteome.3c00188. Epub 2023 Jun 22.
3 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
12 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
15 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
21 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
23 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
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Mass spectrometry data entry: PXD038010
30 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
31 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
32 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
33 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
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