Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment36  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 67 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03681  DNA replication licensing factor MCM5 (MCM5) C482 20.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 20.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 20.0
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 20.0
 LDTP02502  Thioredoxin (TXN) C32 20.0
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 20.0
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 12.5
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 4.0
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 3.1
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 3.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 3.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 2.7
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.6
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 2.5
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 2.4
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 2.3
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 2.3
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 2.1
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 2.1
 LDTP04374  Dynamin-2 (DNM2) C27 2.0
 LDTP10002  Ribonuclease P/MRP protein subunit POP5 (POP5) C146 2.0
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 1.9
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.9
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.9
 LDTP02672  Elongation factor 2 (EEF2) C41 1.8
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.8
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.8
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.8
 LDTP00482  Peripheral plasma membrane protein CASK (CASK) C914 1.7
 LDTP09912  DNA repair protein RAD50 (RAD50) C1302 1.7
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.7
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.7
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 1.7
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 1.6
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.6
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.6
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 1.6
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.5
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.5
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 1.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.5
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.5
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.4
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 1.4
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.4
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 1.3
 LDTP04211  Isocitrate dehydrogenase [NADP], mitochondrial (IDH2) C308 1.3
 LDTP13147  Cathepsin Z (CTSZ) C92 1.3
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C193 1.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.2
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.2
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 1.2
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.1
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.1
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.1
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 1.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.0
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 0.9
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.9
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 20.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 2.8
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.3
 LDTP00501  Exportin-1 (XPO1) C34 1.3
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.2
 LDTP01574  Importin-7 (IPO7) C757 1.0
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10756  Nucleus accumbens-associated protein 1 (NACC1) C416 3.2
 LDTP05485  Recombining binding protein suppressor of hairless (RBPJ) C313 2.4
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.5
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.3
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.3
Other
Click to Show/Hide to Show 55 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 20.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 20.0
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 20.0
 LDTP13925  Nucleolar protein 58 (NOP58) C106 3.3
 LDTP12412  Reticulon-4 (RTN4) C1101 2.6
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 2.4
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.3
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 2.3
 LDTP18494  Tropomodulin-3 (TMOD3) C132 2.2
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 2.1
 LDTP00727  U4/U6.U5 tri-snRNP-associated protein 1 (SART1) C645 2.1
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 2.1
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 2.1
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 2.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 2.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 2.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 2.0
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.9
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.9
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.9
 LDTP10864  Calponin-2 (CNN2) C215 1.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.8
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.8
 LDTP02205  Tubulin beta chain (TUBB) C354 1.8
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.8
 LDTP13580  Coronin-1C (CORO1C) C420 1.8
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.7
 LDTP05867  Treacle protein (TCOF1) C38 1.7
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.7
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 1.7
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.6
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C116 1.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.6
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.6
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.6
 LDTP06330  Plectin (PLEC) C3110 1.6
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.5
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.5
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 1.4
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.4
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.4
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.3
 LDTP01320  Eukaryotic translation initiation factor 3 subunit J (EIF3J) C207 1.3
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.3
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 1.3
 LDTP02205  Tubulin beta chain (TUBB) C239 1.3
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.2
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.2
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 1.1
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.1
 LDTP03620  Protein S100-A11 (S100A11) C91 1.1
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.0

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.