Details of the Target

General Information of Target

Target ID LDTP05859
Target Name Integrin-linked protein kinase (ILK)
Gene Name ILK
Gene ID 3611
Synonyms
ILK1; ILK2; Integrin-linked protein kinase; EC 2.7.11.1; 59 kDa serine/threonine-protein kinase; Beta-integrin-linked kinase; ILK-1; ILK-2; p59ILK
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDDIFTQCREGNAVAVRLWLDNTENDLNQGDDHGFSPLHWACREGRSAVVEMLIMRGARI
NVMNRGDDTPLHLAASHGHRDIVQKLLQYKADINAVNEHGNVPLHYACFWGQDQVAEDLV
ANGALVSICNKYGEMPVDKAKAPLRELLRERAEKMGQNLNRIPYKDTFWKGTTRTRPRNG
TLNKHSGIDFKQLNFLTKLNENHSGELWKGRWQGNDIVVKVLKVRDWSTRKSRDFNEECP
RLRIFSHPNVLPVLGACQSPPAPHPTLITHWMPYGSLYNVLHEGTNFVVDQSQAVKFALD
MARGMAFLHTLEPLIPRHALNSRSVMIDEDMTARISMADVKFSFQCPGRMYAPAWVAPEA
LQKKPEDTNRRSADMWSFAVLLWELVTREVPFADLSNMEIGMKVALEGLRPTIPPGISPH
VCKLMKICMNEDPAKRPKFDMIVPILEKMQDK
Target Type
Patented-recorded
Target Bioclass
Enzyme
Family
Protein kinase superfamily, TKL Ser/Thr protein kinase family
Subcellular location
Cell junction, focal adhesion
Function
Receptor-proximal protein kinase regulating integrin-mediated signal transduction. May act as a mediator of inside-out integrin signaling. Focal adhesion protein part of the complex ILK-PINCH. This complex is considered to be one of the convergence points of integrin- and growth factor-signaling pathway. Could be implicated in mediating cell architecture, adhesion to integrin substrates and anchorage-dependent growth in epithelial cells. Regulates cell motility by forming a complex with PARVB. Phosphorylates beta-1 and beta-3 integrin subunit on serine and threonine residues, but also AKT1 and GSK3B.
TTD ID
T13616
Uniprot ID
Q13418
DrugMap ID
TT7ALZG
Ensemble ID
ENST00000299421.9
HGNC ID
HGNC:6040
ChEMBL ID
CHEMBL5247

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.L207P DBIA    Probe Info 
DEL SNV: p.P353L DBIA    Probe Info 
HUPT3 SNV: p.D21G DBIA    Probe Info 
IGROV1 Deletion: p.L71CfsTer26
SNV: p.A333V		 DBIA    Probe Info 
SUPT1 Insertion: p.A58GfsTer11 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K139(4.45); K141(2.44); K165(8.07); K170(6.06)  LDD0277  [2]
BTD
 Probe Info  		C346(6.85)  LDD1699  [3]
ONAyne
 Probe Info  		K209(10.00)  LDD0275  [2]
AHL-Pu-1
 Probe Info  		C422(3.16)  LDD0168  [4]
DBIA
 Probe Info  		C428(0.90); C239(0.89)  LDD0078  [5]
ATP probe
 Probe Info  		K341(0.00); K220(0.00)  LDD0199  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C239(0.00); C346(0.00); C428(0.00); C42(0.00)  LDD0038  [7]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C239(0.00); C346(0.00); C428(0.00); C42(0.00)  LDD0037  [7]
ATP probe
 Probe Info  		N.A.  LDD0035  [10]
JW-RF-010
 Probe Info  		C239(0.00); C346(0.00)  LDD0026  [11]
NAIA_4
 Probe Info  		C42(0.00); C239(0.00); C346(0.00)  LDD2226  [12]
TFBX
 Probe Info  		C428(0.00); C239(0.00); C346(0.00); C8(0.00)  LDD0027  [11]
WYneN
 Probe Info  		C428(0.00); C346(0.00)  LDD0021  [13]
WYneO
 Probe Info  		C428(0.00); C346(0.00)  LDD0022  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		C346(0.00); C428(0.00)  LDD0005  [13]
VSF
 Probe Info  		C422(0.00); C239(0.00)  LDD0007  [13]
YN-1
 Probe Info  		N.A.  LDD0446  [15]
Acrolein
 Probe Info  		C346(0.00); C239(0.00); H203(0.00)  LDD0217  [16]
Crotonaldehyde
 Probe Info  		C239(0.00); C346(0.00)  LDD0219  [16]
Methacrolein
 Probe Info  		C346(0.00); C239(0.00)  LDD0218  [16]
W1
 Probe Info  		C428(0.00); C346(0.00); C239(0.00); C422(0.00)  LDD0236  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C428(0.00); C239(0.00); C42(0.00); C422(0.00)  LDD2223  [12]
HHS-475
 Probe Info  		Y132(1.69)  LDD2238  [19]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0137  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C428(0.62)  LDD2095  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C428(1.46)  LDD2117  [3]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C346(1.14)  LDD2152  [3]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C422(0.97)  LDD2103  [3]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C428(0.56)  LDD2132  [3]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C428(0.48); C346(1.07)  LDD2131  [3]
 LDCM0025  4SU-RNA HEK-293T C422(3.16)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C422(2.87)  LDD0169  [4]
 LDCM0214  AC1 HCT 116 C239(0.83); C346(1.05); C422(1.22); C428(0.65)  LDD0531  [5]
 LDCM0215  AC10 HCT 116 C239(1.03); C346(1.16); C42(0.76); C428(1.03)  LDD0532  [5]
 LDCM0216  AC100 HCT 116 C239(1.08); C346(1.15); C422(0.86); C428(0.83)  LDD0533  [5]
 LDCM0217  AC101 HCT 116 C239(0.94); C346(1.10); C422(0.80); C428(0.84)  LDD0534  [5]
 LDCM0218  AC102 HCT 116 C239(0.94); C346(1.17); C422(0.95); C428(0.79)  LDD0535  [5]
 LDCM0219  AC103 HCT 116 C239(0.93); C346(1.43); C422(1.11); C428(1.01)  LDD0536  [5]
 LDCM0220  AC104 HCT 116 C239(0.87); C346(1.26); C422(1.15); C428(0.94)  LDD0537  [5]
 LDCM0221  AC105 HCT 116 C239(1.05); C346(1.41); C422(1.10); C428(0.98)  LDD0538  [5]
 LDCM0222  AC106 HCT 116 C239(1.22); C346(1.43); C422(1.09); C428(1.01)  LDD0539  [5]
 LDCM0223  AC107 HCT 116 C239(1.44); C346(1.57); C422(0.83); C428(0.96)  LDD0540  [5]
 LDCM0224  AC108 HCT 116 C239(1.11); C346(1.16); C422(1.26); C428(0.96)  LDD0541  [5]
 LDCM0225  AC109 HCT 116 C239(1.03); C346(1.03); C422(1.32); C428(0.77)  LDD0542  [5]
 LDCM0226  AC11 HCT 116 C239(1.07); C346(1.36); C42(0.82); C428(0.96)  LDD0543  [5]
 LDCM0227  AC110 HCT 116 C239(1.18); C346(1.12); C422(1.11); C428(0.92)  LDD0544  [5]
 LDCM0228  AC111 HCT 116 C239(1.00); C346(1.33); C422(0.98); C428(0.91)  LDD0545  [5]
 LDCM0229  AC112 HCT 116 C239(1.07); C346(1.42); C422(0.80); C428(0.85)  LDD0546  [5]
 LDCM0230  AC113 HCT 116 C239(0.86); C346(1.04); C422(0.99); C428(0.88)  LDD0547  [5]
 LDCM0231  AC114 HCT 116 C239(1.04); C346(1.23); C422(1.06); C428(0.91)  LDD0548  [5]
 LDCM0232  AC115 HCT 116 C239(1.21); C346(1.43); C422(1.09); C428(0.85)  LDD0549  [5]
 LDCM0233  AC116 HCT 116 C239(1.01); C346(1.37); C422(1.10); C428(0.97)  LDD0550  [5]
 LDCM0234  AC117 HCT 116 C239(1.01); C346(1.29); C422(1.01); C428(0.92)  LDD0551  [5]
 LDCM0235  AC118 HCT 116 C239(1.01); C346(1.12); C422(0.92); C428(0.85)  LDD0552  [5]
 LDCM0236  AC119 HCT 116 C239(0.97); C346(1.17); C422(1.02); C428(0.91)  LDD0553  [5]
 LDCM0237  AC12 HCT 116 C239(1.10); C346(1.28); C42(1.05); C428(1.02)  LDD0554  [5]
 LDCM0238  AC120 HCT 116 C239(0.93); C346(1.16); C422(1.28); C428(0.79)  LDD0555  [5]
 LDCM0239  AC121 HCT 116 C239(1.07); C346(1.22); C422(0.94); C428(0.92)  LDD0556  [5]
 LDCM0240  AC122 HCT 116 C239(0.96); C346(1.31); C422(0.87); C428(0.89)  LDD0557  [5]
 LDCM0241  AC123 HCT 116 C239(1.25); C346(1.41); C422(1.00); C428(0.89)  LDD0558  [5]
 LDCM0242  AC124 HCT 116 C239(0.94); C346(1.06); C422(0.94); C428(0.99)  LDD0559  [5]
 LDCM0243  AC125 HCT 116 C239(1.02); C346(1.20); C422(0.94); C428(0.86)  LDD0560  [5]
 LDCM0244  AC126 HCT 116 C239(1.09); C346(1.31); C422(1.05); C428(1.00)  LDD0561  [5]
 LDCM0245  AC127 HCT 116 C239(1.12); C346(1.45); C422(0.97); C428(1.00)  LDD0562  [5]
 LDCM0246  AC128 HCT 116 C239(1.11); C346(1.40); C422(1.04); C428(1.12)  LDD0563  [5]
 LDCM0247  AC129 HCT 116 C239(1.02); C346(0.85); C422(0.92); C428(0.80)  LDD0564  [5]
 LDCM0249  AC130 HCT 116 C239(0.85); C346(1.21); C422(0.93); C428(0.78)  LDD0566  [5]
 LDCM0250  AC131 HCT 116 C239(0.80); C346(0.92); C422(0.80); C428(0.90)  LDD0567  [5]
 LDCM0251  AC132 HCT 116 C239(1.16); C346(0.99); C422(0.85); C428(0.97)  LDD0568  [5]
 LDCM0252  AC133 HCT 116 C239(0.95); C346(1.13); C422(0.99); C428(1.05)  LDD0569  [5]
 LDCM0253  AC134 HCT 116 C239(0.84); C346(1.18); C422(1.01); C428(0.99)  LDD0570  [5]
 LDCM0254  AC135 HCT 116 C239(0.99); C346(1.24); C422(1.10); C428(1.02)  LDD0571  [5]
 LDCM0255  AC136 HCT 116 C239(1.11); C346(1.13); C422(1.09); C428(1.17)  LDD0572  [5]
 LDCM0256  AC137 HCT 116 C239(0.80); C346(1.07); C422(1.10); C428(0.97)  LDD0573  [5]
 LDCM0257  AC138 HCT 116 C239(0.98); C346(1.20); C422(1.02); C428(0.88)  LDD0574  [5]
 LDCM0258  AC139 HCT 116 C239(1.37); C346(1.16); C422(0.95); C428(1.05)  LDD0575  [5]
 LDCM0259  AC14 HCT 116 C239(1.03); C346(1.21); C42(0.64); C428(0.91)  LDD0576  [5]
 LDCM0260  AC140 HCT 116 C239(1.15); C346(1.27); C422(1.04); C428(1.20)  LDD0577  [5]
 LDCM0261  AC141 HCT 116 C239(1.38); C346(1.15); C422(1.06); C428(1.13)  LDD0578  [5]
 LDCM0262  AC142 HCT 116 C239(1.05); C346(0.96); C422(1.04); C428(1.02)  LDD0579  [5]
 LDCM0263  AC143 HCT 116 C239(1.03); C346(1.23); C42(0.71); C428(0.91)  LDD0580  [5]
 LDCM0264  AC144 HCT 116 C42(0.85); C428(0.90); C239(1.13); C346(1.58)  LDD0581  [5]
 LDCM0265  AC145 HCT 116 C42(0.61); C428(0.81); C239(0.97); C346(1.39)  LDD0582  [5]
 LDCM0266  AC146 HCT 116 C42(0.49); C239(0.95); C428(1.00); C346(1.34)  LDD0583  [5]
 LDCM0267  AC147 HCT 116 C42(0.57); C428(0.98); C239(1.07); C346(1.52)  LDD0584  [5]
 LDCM0268  AC148 HCT 116 C42(0.83); C428(1.04); C239(1.37); C346(2.11)  LDD0585  [5]
 LDCM0269  AC149 HCT 116 C42(0.65); C428(0.86); C239(1.23); C346(1.69)  LDD0586  [5]
 LDCM0270  AC15 HCT 116 C42(0.84); C428(1.03); C239(1.20); C346(1.38)  LDD0587  [5]
 LDCM0271  AC150 HCT 116 C42(0.71); C428(0.91); C239(1.06); C346(1.40)  LDD0588  [5]
 LDCM0272  AC151 HCT 116 C42(0.64); C239(0.99); C346(1.20); C428(1.25)  LDD0589  [5]
 LDCM0273  AC152 HCT 116 C42(0.78); C239(0.96); C428(1.18); C346(1.77)  LDD0590  [5]
 LDCM0274  AC153 HCT 116 C42(0.70); C428(1.12); C239(1.58); C346(2.20)  LDD0591  [5]
 LDCM0621  AC154 HCT 116 C239(1.45); C346(1.47); C42(0.61); C428(1.06)  LDD2158  [5]
 LDCM0622  AC155 HCT 116 C239(1.06); C346(1.52); C42(0.69); C428(1.30)  LDD2159  [5]
 LDCM0623  AC156 HCT 116 C239(1.25); C346(1.21); C42(0.81); C428(1.11)  LDD2160  [5]
 LDCM0624  AC157 HCT 116 C239(1.13); C346(1.13); C42(0.82); C428(1.01)  LDD2161  [5]
 LDCM0276  AC17 HCT 116 C422(0.87); C428(0.90); C42(0.90); C239(1.07)  LDD0593  [5]
 LDCM0277  AC18 HCT 116 C42(0.76); C422(0.94); C239(1.14); C428(1.21)  LDD0594  [5]
 LDCM0278  AC19 HCT 116 C422(0.85); C42(0.93); C239(0.96); C428(1.09)  LDD0595  [5]
 LDCM0279  AC2 HCT 116 C428(0.76); C239(0.93); C346(1.03); C422(1.16)  LDD0596  [5]
 LDCM0280  AC20 HCT 116 C422(0.86); C42(0.91); C428(0.96); C239(0.98)  LDD0597  [5]
 LDCM0281  AC21 HCT 116 C42(0.88); C428(0.92); C422(1.01); C239(1.08)  LDD0598  [5]
 LDCM0282  AC22 HCT 116 C422(0.84); C428(0.90); C346(1.13); C239(1.15)  LDD0599  [5]
 LDCM0283  AC23 HCT 116 C422(0.75); C42(0.82); C428(1.00); C346(1.04)  LDD0600  [5]
 LDCM0284  AC24 HCT 116 C422(0.79); C346(0.96); C239(0.98); C428(1.02)  LDD0601  [5]
 LDCM0285  AC25 HCT 116 C428(0.68); C42(0.88); C346(0.89); C239(1.05)  LDD0602  [5]
 LDCM0286  AC26 HCT 116 C428(0.75); C42(0.82); C346(0.89); C239(1.22)  LDD0603  [5]
 LDCM0287  AC27 HCT 116 C428(0.71); C42(0.79); C346(0.89); C239(1.09)  LDD0604  [5]
 LDCM0288  AC28 HCT 116 C428(0.75); C42(0.81); C346(0.94); C239(1.17)  LDD0605  [5]
 LDCM0289  AC29 HCT 116 C428(0.77); C346(1.03); C42(1.10); C239(1.22)  LDD0606  [5]
 LDCM0290  AC3 HCT 116 C428(0.87); C239(0.94); C346(1.04); C422(1.16)  LDD0607  [5]
 LDCM0291  AC30 HCT 116 C428(0.69); C42(1.12); C239(1.17); C346(1.39)  LDD0608  [5]
 LDCM0292  AC31 HCT 116 C42(0.78); C428(0.80); C346(0.88); C239(1.06)  LDD0609  [5]
 LDCM0293  AC32 HCT 116 C428(0.70); C42(0.76); C239(1.05); C346(1.18)  LDD0610  [5]
 LDCM0294  AC33 HCT 116 C428(0.84); C346(0.95); C42(1.03); C239(1.03)  LDD0611  [5]
 LDCM0295  AC34 HCT 116 C428(0.84); C239(0.99); C346(1.00); C42(1.03)  LDD0612  [5]
 LDCM0296  AC35 HCT 116 C42(0.89); C346(0.96); C428(0.98); C239(1.09)  LDD0613  [5]
 LDCM0297  AC36 HCT 116 C42(0.73); C346(0.92); C239(0.99); C428(1.05)  LDD0614  [5]
 LDCM0298  AC37 HCT 116 C42(0.81); C428(0.98); C346(1.05); C239(1.25)  LDD0615  [5]
 LDCM0299  AC38 HCT 116 C346(0.97); C42(0.97); C428(1.01); C239(1.17)  LDD0616  [5]
 LDCM0300  AC39 HCT 116 C42(1.08); C346(1.16); C428(1.16); C239(1.41)  LDD0617  [5]
 LDCM0301  AC4 HCT 116 C428(0.79); C346(0.95); C239(1.11); C422(1.30)  LDD0618  [5]
 LDCM0302  AC40 HCT 116 C42(1.09); C428(1.12); C346(1.16); C239(1.30)  LDD0619  [5]
 LDCM0303  AC41 HCT 116 C42(0.87); C346(1.13); C428(1.15); C239(1.28)  LDD0620  [5]
 LDCM0304  AC42 HCT 116 C42(0.92); C428(0.98); C346(1.16); C239(1.18)  LDD0621  [5]
 LDCM0305  AC43 HCT 116 C42(0.97); C428(1.10); C346(1.16); C239(1.34)  LDD0622  [5]
 LDCM0306  AC44 HCT 116 C42(0.87); C428(1.12); C346(1.16); C239(1.19)  LDD0623  [5]
 LDCM0307  AC45 HCT 116 C428(1.08); C42(1.11); C239(1.21); C346(1.31)  LDD0624  [5]
 LDCM0308  AC46 HCT 116 C428(0.93); C42(1.02); C346(1.05); C239(1.10)  LDD0625  [5]
 LDCM0309  AC47 HCT 116 C42(0.89); C239(1.02); C428(1.07); C346(1.09)  LDD0626  [5]
 LDCM0310  AC48 HCT 116 C42(0.86); C239(1.22); C346(1.23); C428(1.27)  LDD0627  [5]
 LDCM0311  AC49 HCT 116 C428(1.19); C239(1.25); C42(1.26); C346(1.36)  LDD0628  [5]
 LDCM0312  AC5 HCT 116 C428(0.89); C239(0.96); C346(0.98); C422(1.31)  LDD0629  [5]
 LDCM0313  AC50 HCT 116 C42(1.09); C239(1.31); C346(1.56); C428(1.61)  LDD0630  [5]
 LDCM0314  AC51 HCT 116 C346(0.99); C42(1.04); C239(1.07); C428(1.28)  LDD0631  [5]
 LDCM0315  AC52 HCT 116 C42(0.97); C428(1.10); C239(1.16); C346(1.51)  LDD0632  [5]
 LDCM0316  AC53 HCT 116 C428(1.00); C42(1.04); C239(1.09); C346(1.27)  LDD0633  [5]
 LDCM0317  AC54 HCT 116 C239(1.08); C428(1.20); C42(1.32); C346(1.36)  LDD0634  [5]
 LDCM0318  AC55 HCT 116 C428(1.17); C42(1.17); C239(1.24); C346(1.67)  LDD0635  [5]
 LDCM0319  AC56 HCT 116 C42(1.07); C239(1.42); C428(1.49); C346(1.73)  LDD0636  [5]
 LDCM0320  AC57 HCT 116 C428(0.96); C422(1.08); C239(1.08); C346(1.49)  LDD0637  [5]
 LDCM0321  AC58 HCT 116 C428(0.73); C422(0.96); C239(1.16); C346(1.47)  LDD0638  [5]
 LDCM0322  AC59 HCT 116 C428(0.94); C239(1.05); C422(1.07); C346(1.43)  LDD0639  [5]
 LDCM0323  AC6 HCT 116 C42(0.74); C239(1.02); C428(1.02); C346(1.24)  LDD0640  [5]
 LDCM0324  AC60 HCT 116 C428(0.86); C239(1.13); C422(1.22); C346(1.47)  LDD0641  [5]
 LDCM0325  AC61 HCT 116 C422(0.86); C428(0.88); C239(1.36); C346(1.52)  LDD0642  [5]
 LDCM0326  AC62 HCT 116 C422(0.99); C428(1.01); C239(1.13); C346(1.53)  LDD0643  [5]
 LDCM0327  AC63 HCT 116 C428(0.83); C422(0.92); C239(1.24); C346(1.56)  LDD0644  [5]
 LDCM0328  AC64 HCT 116 C428(1.01); C422(1.02); C239(1.16); C346(1.72)  LDD0645  [5]
 LDCM0329  AC65 HCT 116 C422(0.82); C428(0.94); C239(1.16); C346(1.90)  LDD0646  [5]
 LDCM0330  AC66 HCT 116 C422(0.85); C428(0.96); C239(1.18); C346(1.86)  LDD0647  [5]
 LDCM0331  AC67 HCT 116 C422(0.84); C428(0.89); C239(1.03); C346(1.95)  LDD0648  [5]
 LDCM0332  AC68 HCT 116 C428(1.04); C422(1.05); C239(1.21); C346(1.24)  LDD0649  [5]
 LDCM0333  AC69 HCT 116 C422(0.88); C428(1.16); C239(1.37); C346(1.43)  LDD0650  [5]
 LDCM0334  AC7 HCT 116 C42(0.86); C428(0.91); C239(1.04); C346(1.31)  LDD0651  [5]
 LDCM0335  AC70 HCT 116 C422(0.74); C428(0.90); C346(1.42); C239(1.42)  LDD0652  [5]
 LDCM0336  AC71 HCT 116 C422(0.91); C346(1.20); C428(1.27); C239(1.37)  LDD0653  [5]
 LDCM0337  AC72 HCT 116 C422(0.87); C428(1.10); C346(1.39); C239(1.41)  LDD0654  [5]
 LDCM0338  AC73 HCT 116 C422(0.90); C428(1.18); C239(1.54); C346(1.87)  LDD0655  [5]
 LDCM0339  AC74 HCT 116 C428(1.07); C422(1.11); C239(1.55); C346(1.81)  LDD0656  [5]
 LDCM0340  AC75 HCT 116 C422(0.77); C428(1.23); C239(1.75); C346(1.91)  LDD0657  [5]
 LDCM0341  AC76 HCT 116 C422(0.88); C428(1.21); C346(1.57); C239(1.62)  LDD0658  [5]
 LDCM0342  AC77 HCT 116 C428(0.98); C422(1.12); C346(1.63); C239(1.71)  LDD0659  [5]
 LDCM0343  AC78 HCT 116 C422(0.99); C428(1.00); C239(1.32); C346(1.35)  LDD0660  [5]
 LDCM0344  AC79 HCT 116 C422(0.90); C428(1.13); C239(1.36); C346(1.36)  LDD0661  [5]
 LDCM0345  AC8 HCT 116 C42(0.80); C428(0.96); C239(1.09); C346(1.14)  LDD0662  [5]
 LDCM0346  AC80 HCT 116 C428(0.90); C422(0.98); C239(1.27); C346(1.45)  LDD0663  [5]
 LDCM0347  AC81 HCT 116 C422(0.91); C428(1.22); C239(1.23); C346(1.29)  LDD0664  [5]
 LDCM0348  AC82 HCT 116 C422(0.87); C428(1.40); C239(1.69); C346(1.76)  LDD0665  [5]
 LDCM0349  AC83 HCT 116 C428(0.95); C239(0.99); C346(1.32); C422(1.39)  LDD0666  [5]
 LDCM0350  AC84 HCT 116 C239(0.91); C428(0.94); C422(1.50); C346(1.53)  LDD0667  [5]
 LDCM0351  AC85 HCT 116 C428(0.86); C239(1.04); C422(1.24); C346(1.32)  LDD0668  [5]
 LDCM0352  AC86 HCT 116 C428(0.86); C239(0.93); C422(1.15); C346(1.18)  LDD0669  [5]
 LDCM0353  AC87 HCT 116 C428(0.90); C239(1.00); C346(1.03); C422(1.15)  LDD0670  [5]
 LDCM0354  AC88 HCT 116 C239(0.97); C428(0.98); C346(1.11); C422(1.14)  LDD0671  [5]
 LDCM0355  AC89 HCT 116 C428(0.97); C239(1.04); C422(1.05); C346(1.24)  LDD0672  [5]
 LDCM0357  AC90 HCT 116 C422(0.66); C428(1.04); C346(1.08); C239(1.30)  LDD0674  [5]
 LDCM0358  AC91 HCT 116 C428(1.05); C239(1.11); C422(1.36); C346(1.77)  LDD0675  [5]
 LDCM0359  AC92 HCT 116 C239(1.15); C428(1.16); C422(1.33); C346(1.35)  LDD0676  [5]
 LDCM0360  AC93 HCT 116 C428(0.92); C239(1.02); C422(1.28); C346(1.29)  LDD0677  [5]
 LDCM0361  AC94 HCT 116 C428(0.78); C239(1.03); C422(1.19); C346(1.58)  LDD0678  [5]
 LDCM0362  AC95 HCT 116 C428(0.87); C239(1.09); C422(1.10); C346(1.33)  LDD0679  [5]
 LDCM0363  AC96 HCT 116 C428(0.94); C239(0.98); C422(1.17); C346(1.47)  LDD0680  [5]
 LDCM0364  AC97 HCT 116 C428(0.94); C239(1.13); C422(1.40); C346(1.73)  LDD0681  [5]
 LDCM0365  AC98 HCT 116 C428(1.03); C239(1.13); C422(1.15); C346(1.79)  LDD0682  [5]
 LDCM0366  AC99 HCT 116 C422(0.85); C428(0.92); C239(0.99); C346(1.21)  LDD0683  [5]
 LDCM0520  AKOS000195272 MDA-MB-231 C346(0.67)  LDD2113  [3]
 LDCM0248  AKOS034007472 HCT 116 C239(1.11); C346(1.11); C42(0.78); C428(1.12)  LDD0565  [5]
 LDCM0356  AKOS034007680 HCT 116 C42(0.78); C428(0.97); C239(1.07); C346(1.33)  LDD0673  [5]
 LDCM0275  AKOS034007705 HCT 116 C42(0.71); C428(1.12); C239(1.22); C346(1.65)  LDD0592  [5]
 LDCM0156  Aniline NCI-H1299 11.45  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C428(0.90); C239(0.89)  LDD0078  [5]
 LDCM0498  BS-3668 MDA-MB-231 C346(0.52)  LDD2091  [3]
 LDCM0108  Chloroacetamide HeLa H309(0.00); C422(0.00); C346(0.00); C239(0.00)  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C428(3.87); C346(0.98); C8(0.79); C422(0.63)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C428(0.97); C346(1.04); C422(1.13); C239(1.14)  LDD0684  [5]
 LDCM0368  CL10 HCT 116 C422(1.01); C428(1.03); C239(1.12); C346(1.31)  LDD0685  [5]
 LDCM0369  CL100 HCT 116 C428(0.76); C239(0.92); C346(1.08); C422(1.23)  LDD0686  [5]
 LDCM0370  CL101 HCT 116 C42(0.70); C239(0.94); C428(1.01); C346(1.27)  LDD0687  [5]
 LDCM0371  CL102 HCT 116 C42(0.88); C428(0.97); C239(1.04); C346(1.20)  LDD0688  [5]
 LDCM0372  CL103 HCT 116 C42(0.92); C239(0.94); C428(0.94); C346(1.03)  LDD0689  [5]
 LDCM0373  CL104 HCT 116 C42(0.88); C239(0.93); C428(0.99); C346(1.27)  LDD0690  [5]
 LDCM0374  CL105 HCT 116 C42(0.71); C428(0.79); C239(0.82); C422(0.96)  LDD0691  [5]
 LDCM0375  CL106 HCT 116 C42(0.73); C239(0.98); C422(1.11); C428(1.18)  LDD0692  [5]
 LDCM0376  CL107 HCT 116 C42(0.71); C422(0.92); C428(0.95); C239(1.08)  LDD0693  [5]
 LDCM0377  CL108 HCT 116 C42(0.77); C428(0.98); C239(0.99); C422(1.02)  LDD0694  [5]
 LDCM0378  CL109 HCT 116 C42(0.73); C239(0.95); C428(0.97); C422(1.04)  LDD0695  [5]
 LDCM0379  CL11 HCT 116 C422(1.01); C239(1.09); C428(1.18); C346(1.38)  LDD0696  [5]
 LDCM0380  CL110 HCT 116 C42(0.72); C239(1.01); C428(1.02); C422(1.03)  LDD0697  [5]
 LDCM0381  CL111 HCT 116 C42(0.87); C239(0.93); C422(0.98); C428(1.00)  LDD0698  [5]
 LDCM0382  CL112 HCT 116 C428(0.80); C239(0.97); C346(1.06); C42(1.10)  LDD0699  [5]
 LDCM0383  CL113 HCT 116 C42(0.74); C428(0.76); C346(0.88); C239(1.04)  LDD0700  [5]
 LDCM0384  CL114 HCT 116 C428(0.80); C42(0.98); C346(1.07); C239(1.10)  LDD0701  [5]
 LDCM0385  CL115 HCT 116 C428(0.82); C42(0.85); C239(0.98); C346(0.99)  LDD0702  [5]
 LDCM0386  CL116 HCT 116 C42(0.72); C428(0.84); C239(0.95); C346(1.13)  LDD0703  [5]
 LDCM0387  CL117 HCT 116 C42(1.00); C239(1.33); C428(1.42); C346(1.47)  LDD0704  [5]
 LDCM0388  CL118 HCT 116 C428(1.06); C42(1.09); C239(1.10); C346(1.13)  LDD0705  [5]
 LDCM0389  CL119 HCT 116 C428(0.99); C346(1.08); C42(1.09); C239(1.39)  LDD0706  [5]
 LDCM0390  CL12 HCT 116 C422(0.91); C428(1.18); C346(1.30); C239(1.34)  LDD0707  [5]
 LDCM0391  CL120 HCT 116 C42(1.01); C346(1.06); C428(1.09); C239(1.17)  LDD0708  [5]
 LDCM0392  CL121 HCT 116 C42(0.77); C346(0.85); C239(0.85); C428(1.49)  LDD0709  [5]
 LDCM0393  CL122 HCT 116 C42(0.92); C428(1.02); C239(1.08); C346(1.30)  LDD0710  [5]
 LDCM0394  CL123 HCT 116 C42(1.01); C239(1.04); C428(1.14); C346(1.16)  LDD0711  [5]
 LDCM0395  CL124 HCT 116 C42(1.05); C239(1.10); C428(1.12); C346(1.46)  LDD0712  [5]
 LDCM0396  CL125 HCT 116 C428(0.82); C422(1.07); C346(1.09); C239(1.23)  LDD0713  [5]
 LDCM0397  CL126 HCT 116 C428(0.85); C239(0.90); C346(1.11); C422(1.15)  LDD0714  [5]
 LDCM0398  CL127 HCT 116 C428(0.80); C239(0.98); C422(1.00); C346(1.39)  LDD0715  [5]
 LDCM0399  CL128 HCT 116 C428(0.83); C239(1.09); C422(1.10); C346(1.38)  LDD0716  [5]
 LDCM0400  CL13 HCT 116 C422(0.80); C428(0.97); C239(1.14); C346(1.23)  LDD0717  [5]
 LDCM0401  CL14 HCT 116 C422(0.82); C239(0.94); C428(1.00); C346(1.17)  LDD0718  [5]
 LDCM0402  CL15 HCT 116 C422(0.79); C428(1.14); C239(1.15); C346(1.25)  LDD0719  [5]
 LDCM0403  CL16 HCT 116 C239(0.85); C346(0.91); C428(0.99)  LDD0720  [5]
 LDCM0404  CL17 HCT 116 C239(1.02); C428(1.11); C346(1.47)  LDD0721  [5]
 LDCM0405  CL18 HCT 116 C428(0.85); C239(0.91); C346(1.27)  LDD0722  [5]
 LDCM0406  CL19 HCT 116 C239(0.88); C428(1.16); C346(1.26)  LDD0723  [5]
 LDCM0407  CL2 HCT 116 C422(0.95); C428(0.96); C346(1.10); C239(1.13)  LDD0724  [5]
 LDCM0408  CL20 HCT 116 C428(0.93); C239(1.08); C346(1.58)  LDD0725  [5]
 LDCM0409  CL21 HCT 116 C239(0.90); C428(0.91); C346(1.57)  LDD0726  [5]
 LDCM0410  CL22 HCT 116 C428(0.88); C239(1.18); C346(1.60)  LDD0727  [5]
 LDCM0411  CL23 HCT 116 C239(0.88); C428(1.07); C346(1.14)  LDD0728  [5]
 LDCM0412  CL24 HCT 116 C428(0.98); C239(1.04); C346(1.30)  LDD0729  [5]
 LDCM0413  CL25 HCT 116 C239(1.04); C346(1.40); C428(0.97)  LDD0730  [5]
 LDCM0414  CL26 HCT 116 C239(1.01); C346(1.16); C428(1.04)  LDD0731  [5]
 LDCM0415  CL27 HCT 116 C239(0.94); C346(1.06); C428(0.92)  LDD0732  [5]
 LDCM0416  CL28 HCT 116 C239(0.95); C346(1.21); C428(1.12)  LDD0733  [5]
 LDCM0417  CL29 HCT 116 C239(0.93); C346(1.40); C428(0.90)  LDD0734  [5]
 LDCM0418  CL3 HCT 116 C239(1.16); C346(1.13); C422(0.98); C428(0.93)  LDD0735  [5]
 LDCM0419  CL30 HCT 116 C239(0.91); C346(1.02); C428(0.92)  LDD0736  [5]
 LDCM0420  CL31 HCT 116 C239(1.20); C346(1.01); C428(1.02)  LDD0737  [5]
 LDCM0421  CL32 HCT 116 C239(1.29); C346(1.13); C428(0.93)  LDD0738  [5]
 LDCM0422  CL33 HCT 116 C239(1.15); C346(1.18); C428(0.79)  LDD0739  [5]
 LDCM0423  CL34 HCT 116 C239(0.96); C346(1.30); C428(0.93)  LDD0740  [5]
 LDCM0424  CL35 HCT 116 C239(1.18); C346(1.27); C428(0.89)  LDD0741  [5]
 LDCM0425  CL36 HCT 116 C239(1.04); C346(1.19); C428(0.88)  LDD0742  [5]
 LDCM0426  CL37 HCT 116 C239(1.19); C346(1.42); C428(0.99)  LDD0743  [5]
 LDCM0428  CL39 HCT 116 C239(1.44); C346(1.34); C428(0.94)  LDD0745  [5]
 LDCM0429  CL4 HCT 116 C239(0.97); C346(0.98); C422(0.99); C428(0.75)  LDD0746  [5]
 LDCM0430  CL40 HCT 116 C239(1.18); C346(1.33); C428(0.86)  LDD0747  [5]
 LDCM0431  CL41 HCT 116 C239(0.98); C346(1.22); C428(0.95)  LDD0748  [5]
 LDCM0432  CL42 HCT 116 C239(1.05); C346(1.62); C428(1.11)  LDD0749  [5]
 LDCM0433  CL43 HCT 116 C239(1.16); C346(1.32); C428(1.08)  LDD0750  [5]
 LDCM0434  CL44 HCT 116 C239(1.20); C346(1.22); C428(1.09)  LDD0751  [5]
 LDCM0435  CL45 HCT 116 C239(1.11); C346(1.38); C428(0.94)  LDD0752  [5]
 LDCM0436  CL46 HCT 116 C239(1.04); C346(0.93); C428(1.01)  LDD0753  [5]
 LDCM0437  CL47 HCT 116 C239(1.04); C346(1.04); C428(0.91)  LDD0754  [5]
 LDCM0438  CL48 HCT 116 C239(1.05); C346(0.91); C428(1.04)  LDD0755  [5]
 LDCM0439  CL49 HCT 116 C239(1.13); C346(0.89); C428(1.05)  LDD0756  [5]
 LDCM0440  CL5 HCT 116 C239(1.22); C346(1.06); C422(0.72); C428(0.92)  LDD0757  [5]
 LDCM0441  CL50 HCT 116 C239(1.04); C346(0.94); C428(1.14)  LDD0758  [5]
 LDCM0442  CL51 HCT 116 C239(1.17); C346(0.98); C428(1.23)  LDD0759  [5]
 LDCM0443  CL52 HCT 116 C239(0.99); C346(1.19); C428(1.23)  LDD0760  [5]
 LDCM0444  CL53 HCT 116 C239(0.93); C346(1.05); C428(1.01)  LDD0761  [5]
 LDCM0445  CL54 HCT 116 C239(1.18); C346(1.00); C428(1.07)  LDD0762  [5]
 LDCM0446  CL55 HCT 116 C239(1.12); C346(0.90); C428(1.15)  LDD0763  [5]
 LDCM0447  CL56 HCT 116 C239(0.96); C346(0.99); C428(0.95)  LDD0764  [5]
 LDCM0448  CL57 HCT 116 C239(0.90); C346(0.96); C428(0.98)  LDD0765  [5]
 LDCM0449  CL58 HCT 116 C239(1.06); C346(0.96); C428(1.18)  LDD0766  [5]
 LDCM0450  CL59 HCT 116 C239(1.14); C346(1.05); C428(1.10)  LDD0767  [5]
 LDCM0451  CL6 HCT 116 C239(1.00); C346(1.08); C422(0.63); C428(1.00)  LDD0768  [5]
 LDCM0452  CL60 HCT 116 C239(0.94); C346(1.08); C428(1.04)  LDD0769  [5]
 LDCM0453  CL61 HCT 116 C239(1.14); C346(1.12); C428(1.07)  LDD0770  [5]
 LDCM0454  CL62 HCT 116 C239(1.25); C346(1.07); C428(1.19)  LDD0771  [5]
 LDCM0455  CL63 HCT 116 C239(1.14); C346(1.27); C428(1.07)  LDD0772  [5]
 LDCM0456  CL64 HCT 116 C239(1.06); C346(1.26); C428(1.09)  LDD0773  [5]
 LDCM0457  CL65 HCT 116 C239(1.28); C346(1.12); C428(1.17)  LDD0774  [5]
 LDCM0458  CL66 HCT 116 C239(1.13); C346(1.47); C428(1.17)  LDD0775  [5]
 LDCM0459  CL67 HCT 116 C239(1.31); C346(1.25); C428(1.08)  LDD0776  [5]
 LDCM0460  CL68 HCT 116 C239(1.11); C346(1.17); C428(1.03)  LDD0777  [5]
 LDCM0461  CL69 HCT 116 C239(1.30); C346(1.27); C428(0.99)  LDD0778  [5]
 LDCM0462  CL7 HCT 116 C239(1.36); C346(1.35); C422(0.64); C428(1.11)  LDD0779  [5]
 LDCM0463  CL70 HCT 116 C239(1.11); C346(1.28); C428(0.98)  LDD0780  [5]
 LDCM0464  CL71 HCT 116 C239(1.48); C346(1.34); C428(1.13)  LDD0781  [5]
 LDCM0465  CL72 HCT 116 C239(1.40); C346(1.09); C428(1.04)  LDD0782  [5]
 LDCM0466  CL73 HCT 116 C239(1.16); C346(1.17); C428(1.02)  LDD0783  [5]
 LDCM0467  CL74 HCT 116 C239(1.18); C346(1.23); C428(1.14)  LDD0784  [5]
 LDCM0469  CL76 HCT 116 C239(0.90); C346(1.08); C428(0.92)  LDD0786  [5]
 LDCM0470  CL77 HCT 116 C239(0.89); C346(1.19); C428(0.80)  LDD0787  [5]
 LDCM0471  CL78 HCT 116 C239(1.05); C346(1.11); C428(0.85)  LDD0788  [5]
 LDCM0472  CL79 HCT 116 C239(1.19); C346(1.25); C428(0.97)  LDD0789  [5]
 LDCM0473  CL8 HCT 116 C239(1.11); C346(1.56); C422(0.86); C428(1.03)  LDD0790  [5]
 LDCM0474  CL80 HCT 116 C239(1.04); C346(1.12); C428(0.94)  LDD0791  [5]
 LDCM0475  CL81 HCT 116 C239(1.08); C346(1.08); C428(0.86)  LDD0792  [5]
 LDCM0476  CL82 HCT 116 C239(0.99); C346(1.31); C428(0.98)  LDD0793  [5]
 LDCM0477  CL83 HCT 116 C239(0.98); C346(1.49); C428(0.91)  LDD0794  [5]
 LDCM0478  CL84 HCT 116 C239(1.13); C346(1.62); C428(1.14)  LDD0795  [5]
 LDCM0479  CL85 HCT 116 C239(0.99); C346(1.23); C428(0.87)  LDD0796  [5]
 LDCM0480  CL86 HCT 116 C239(1.09); C346(1.25); C428(0.79)  LDD0797  [5]
 LDCM0481  CL87 HCT 116 C239(1.00); C346(1.39); C428(0.95)  LDD0798  [5]
 LDCM0482  CL88 HCT 116 C239(1.16); C346(1.33); C428(0.96)  LDD0799  [5]
 LDCM0483  CL89 HCT 116 C239(1.06); C346(1.54); C428(1.31)  LDD0800  [5]
 LDCM0484  CL9 HCT 116 C239(1.15); C346(1.26); C422(0.70); C428(0.99)  LDD0801  [5]
 LDCM0485  CL90 HCT 116 C239(1.03); C346(1.17); C428(0.96)  LDD0802  [5]
 LDCM0486  CL91 HCT 116 C239(1.00); C346(0.98); C422(1.12); C428(0.89)  LDD0803  [5]
 LDCM0487  CL92 HCT 116 C239(0.91); C346(1.18); C422(1.19); C428(0.85)  LDD0804  [5]
 LDCM0488  CL93 HCT 116 C239(1.10); C346(1.00); C422(1.14); C428(0.77)  LDD0805  [5]
 LDCM0489  CL94 HCT 116 C239(0.81); C346(0.88); C422(1.27); C428(0.67)  LDD0806  [5]
 LDCM0490  CL95 HCT 116 C239(0.87); C346(0.96); C422(1.24); C428(0.78)  LDD0807  [5]
 LDCM0491  CL96 HCT 116 C239(0.90); C346(1.03); C422(1.13); C428(0.96)  LDD0808  [5]
 LDCM0492  CL97 HCT 116 C239(0.97); C346(1.12); C422(1.18); C428(0.77)  LDD0809  [5]
 LDCM0493  CL98 HCT 116 C239(1.04); C346(1.07); C422(1.38); C428(0.70)  LDD0810  [5]
 LDCM0494  CL99 HCT 116 C239(1.14); C346(1.05); C422(1.20); C428(0.83)  LDD0811  [5]
 LDCM0634  CY-0357 Hep-G2 C346(0.22)  LDD2228  [12]
 LDCM0495  E2913 HEK-293T C428(0.84); C239(1.00); C422(0.99); C42(1.11)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C422(5.31); C346(4.56)  LDD1702  [3]
 LDCM0625  F8 Ramos C239(1.40)  LDD2187  [22]
 LDCM0572  Fragment10 MDA-MB-231 C346(3.48)  LDD1389  [23]
 LDCM0573  Fragment11 MDA-MB-231 C346(20.00)  LDD1391  [23]
 LDCM0574  Fragment12 MDA-MB-231 C346(1.39)  LDD1393  [23]
 LDCM0575  Fragment13 MDA-MB-231 C346(1.16)  LDD1395  [23]
 LDCM0576  Fragment14 MDA-MB-231 C346(1.27)  LDD1397  [23]
 LDCM0579  Fragment20 MDA-MB-231 C346(6.39)  LDD1402  [23]
 LDCM0580  Fragment21 MDA-MB-231 C346(1.10)  LDD1404  [23]
 LDCM0581  Fragment22 MDA-MB-231 C346(1.19)  LDD1406  [23]
 LDCM0582  Fragment23 MDA-MB-231 C346(1.62)  LDD1408  [23]
 LDCM0583  Fragment24 Ramos C346(1.92)  LDD1410  [23]
 LDCM0584  Fragment25 MDA-MB-231 C346(0.88)  LDD1411  [23]
 LDCM0578  Fragment27 MDA-MB-231 C346(0.79)  LDD1401  [23]
 LDCM0586  Fragment28 MDA-MB-231 C346(0.89)  LDD1415  [23]
 LDCM0587  Fragment29 MDA-MB-231 C346(1.09)  LDD1417  [23]
 LDCM0588  Fragment30 MDA-MB-231 C346(1.14)  LDD1419  [23]
 LDCM0589  Fragment31 MDA-MB-231 C346(1.25)  LDD1421  [23]
 LDCM0590  Fragment32 MDA-MB-231 C346(1.64)  LDD1423  [23]
 LDCM0468  Fragment33 HCT 116 C239(1.11); C346(1.24); C428(1.10)  LDD0785  [5]
 LDCM0592  Fragment34 MDA-MB-231 C346(0.84)  LDD1427  [23]
 LDCM0593  Fragment35 MDA-MB-231 C346(0.80)  LDD1429  [23]
 LDCM0594  Fragment36 MDA-MB-231 C346(1.45)  LDD1431  [23]
 LDCM0595  Fragment37 Ramos C346(1.01)  LDD1432  [23]
 LDCM0596  Fragment38 MDA-MB-231 C346(1.08)  LDD1433  [23]
 LDCM0597  Fragment39 MDA-MB-231 C346(2.45)  LDD1435  [23]
 LDCM0566  Fragment4 MDA-MB-231 C346(1.32)  LDD1378  [23]
 LDCM0598  Fragment40 Ramos C346(0.93)  LDD1437  [23]
 LDCM0599  Fragment41 MDA-MB-231 C346(1.05)  LDD1438  [23]
 LDCM0601  Fragment43 MDA-MB-231 C346(1.64)  LDD1441  [23]
 LDCM0602  Fragment44 MDA-MB-231 C346(0.80)  LDD1443  [23]
 LDCM0603  Fragment45 MDA-MB-231 C346(6.90)  LDD1444  [23]
 LDCM0604  Fragment46 MDA-MB-231 C346(0.85)  LDD1445  [23]
 LDCM0606  Fragment48 MDA-MB-231 C346(1.13)  LDD1447  [23]
 LDCM0607  Fragment49 MDA-MB-231 C346(8.34)  LDD1448  [23]
 LDCM0608  Fragment50 MDA-MB-231 C346(1.34)  LDD1449  [23]
 LDCM0427  Fragment51 HCT 116 C239(1.32); C346(1.47); C428(0.92)  LDD0744  [5]
 LDCM0610  Fragment52 MDA-MB-231 C346(1.01)  LDD1452  [23]
 LDCM0611  Fragment53 MDA-MB-231 C346(0.96)  LDD1454  [23]
 LDCM0612  Fragment54 MDA-MB-231 C346(1.02)  LDD1456  [23]
 LDCM0613  Fragment55 MDA-MB-231 C346(0.72)  LDD1457  [23]
 LDCM0614  Fragment56 MDA-MB-231 C346(0.89)  LDD1458  [23]
 LDCM0569  Fragment7 MDA-MB-231 C346(1.39)  LDD1383  [23]
 LDCM0570  Fragment8 MDA-MB-231 C346(4.37)  LDD1385  [23]
 LDCM0571  Fragment9 MDA-MB-231 C346(1.62)  LDD1387  [23]
 LDCM0015  HNE MDA-MB-231 C422(1.14)  LDD0346  [22]
 LDCM0107  IAA HeLa H72(0.00); H420(0.00); C346(0.00); H309(0.00)  LDD0221  [16]
 LDCM0022  KB02 HCT 116 C422(2.18)  LDD0080  [5]
 LDCM0023  KB03 HCT 116 C422(1.16)  LDD0081  [5]
 LDCM0024  KB05 HCT 116 C422(1.65)  LDD0082  [5]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C422(1.08)  LDD2102  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C428(1.07); C346(0.49)  LDD2121  [3]
 LDCM0109  NEM HeLa H309(0.00); H318(0.00); H203(0.00); H72(0.00)  LDD0223  [16]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C428(0.97); C346(0.51); C239(0.69)  LDD2089  [3]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C422(0.88)  LDD2092  [3]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C428(1.20); C346(1.25)  LDD2093  [3]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C422(1.05)  LDD2094  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C346(0.19)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C422(0.98)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C428(3.00); C346(0.89); C239(1.12)  LDD2099  [3]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C239(0.83); C422(1.53)  LDD2105  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C428(1.17); C346(0.94); C239(1.09)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C428(0.74); C346(0.82)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C428(1.31); C346(1.03)  LDD2111  [3]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C346(0.47)  LDD2118  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C428(1.39); C346(2.14)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C346(0.99)  LDD2120  [3]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C346(0.52)  LDD2122  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C428(0.91); C346(0.79)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C428(1.25); C346(0.68); C239(1.19)  LDD2125  [3]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C346(0.63)  LDD2126  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C346(1.01)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C346(1.23)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C346(1.13)  LDD2129  [3]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C346(0.52)  LDD2134  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C428(1.40); C346(1.23); C239(1.07)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C428(1.28); C346(1.23)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C428(0.83); C422(0.90)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C428(3.12); C346(1.76)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C428(1.28); C346(0.94); C239(0.98)  LDD2140  [3]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C346(1.00)  LDD2143  [3]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C428(1.63); C346(1.90)  LDD2144  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C428(1.33); C346(1.00)  LDD2146  [3]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C346(2.24)  LDD2147  [3]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C346(0.81)  LDD2148  [3]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C346(0.31)  LDD2149  [3]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C346(0.39)  LDD2150  [3]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C422(3.75)  LDD2153  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C346(0.77)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C239(0.98); C346(0.50); C428(0.21)  LDD2207  [24]
 LDCM0131  RA190 MM1.R C346(1.37)  LDD0304  [25]
 LDCM0021  THZ1 HCT 116 C346(1.08); C239(1.26)  LDD2173  [5]
 LDCM0112  W16 Hep-G2 C346(1.58)  LDD0239  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Caspase-8 (CASP8) Peptidase C14A family Q14790
Caspase-9 (CASP9) Peptidase C14A family P55211
Integrin-linked kinase-associated serine/threonine phosphatase 2C (ILKAP) PP2C family Q9H0C8
Zinc finger protein RFP (TRIM27) TRIM/RBCC family P14373
Hypoxia-inducible factor 1-alpha inhibitor (HIF1AN) . Q9NWT6
Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Heat shock protein HSP 90-beta (HSP90AB1) Heat shock protein 90 family P08238
Rapamycin-insensitive companion of mTOR (RICTOR) RICTOR family Q6R327
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-parvin (PARVA) Parvin family Q9NVD7
Gamma-parvin (PARVG) Parvin family Q9HBI0
Synaptopodin-2 (SYNPO2) Synaptopodin family Q9UMS6
Kanadaptin (SLC4A1AP) . Q9BWU0
LIM and senescent cell antigen-like-containing domain protein 1 (LIMS1) . P48059

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid21823616c22 Small molecular drug D01CTM
Mst-400 . D09VFU
Patented
Click To Hide/Show 3 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Us8754233, (4-benzothiazol-2-yl-1h-pyrazol-3-yl)-[2-(1h-imidazol-4-yl)-ethyl]-amine Small molecular drug D0FL7J
Us8754233, 2-(3-amino-1h-pyrazol-4-yl)-5-fluoro-benzothiazole-6-sulfonic Acid Amide Small molecular drug D0Q7KI
Us8754233, 4-(5-fluoro-6-methoxy-benzothiazol-2-yl)-5-(2-fluoro-phenyl)-2h-pyrazol-3-ylamine Small molecular drug D09CNM

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
8 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.