Details of the Target

General Information of Target

Target ID LDTP04390
Target Name T-complex protein 1 subunit theta (CCT8)
Gene Name CCT8
Gene ID 10694
Synonyms
C21orf112; CCTQ; KIAA0002; T-complex protein 1 subunit theta; TCP-1-theta; CCT-theta; Chaperonin containing T-complex polypeptide 1 subunit 8; Renal carcinoma antigen NY-REN-15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALHVPKAPGFAQMLKEGAKHFSGLEEAVYRNIQACKELAQTTRTAYGPNGMNKMVINHL
EKLFVTNDAATILRELEVQHPAAKMIVMASHMQEQEVGDGTNFVLVFAGALLELAEELLR
IGLSVSEVIEGYEIACRKAHEILPNLVCCSAKNLRDIDEVSSLLRTSIMSKQYGNEVFLA
KLIAQACVSIFPDSGHFNVDNIRVCKILGSGISSSSVLHGMVFKKETEGDVTSVKDAKIA
VYSCPFDGMITETKGTVLIKTAEELMNFSKGEENLMDAQVKAIADTGANVVVTGGKVADM
ALHYANKYNIMLVRLNSKWDLRRLCKTVGATALPRLTPPVLEEMGHCDSVYLSEVGDTQV
VVFKHEKEDGAISTIVLRGSTDNLMDDIERAVDDGVNTFKVLTRDKRLVPGGGATEIELA
KQITSYGETCPGLEQYAIKKFAEAFEAIPRALAENSGVKANEVISKLYAVHQEGNKNVGL
DIEAEVPAVKDMLEAGILDTYLGKYWAIKLATNAAVTVLRVDQIIMAKPAGGPKPPSGKK
DWDDDQND
Target Bioclass
Other
Family
TCP-1 chaperonin family
Subcellular location
Cytoplasm
Function
Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin (Probable).
Uniprot ID
P50990
Ensemble ID
ENST00000286788.9
HGNC ID
HGNC:1623
ChEMBL ID
CHEMBL4295775

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A204 SNV: p.M311L DBIA    Probe Info 
CALU1 SNV: p.G195S DBIA    Probe Info 
HCT15 SNV: p.A447D DBIA    Probe Info 
HT SNV: p.A12T DBIA    Probe Info 
ICC3 Insertion: p.G503PfsTer12 DBIA    Probe Info 
MEWO SNV: p.G411R .
MOLT4 SNV: p.E252Ter IA-alkyne    Probe Info 
OSRC2 SNV: p.A488T DBIA    Probe Info 
RBE SNV: p.A488T DBIA    Probe Info 
YSCCC SNV: p.D548H DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 59 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		10.86  LDD0402  [1]
A-EBA
 Probe Info  		3.54  LDD0215  [2]
CHEMBL5175495
 Probe Info  		6.81  LDD0196  [3]
CY-1
 Probe Info  		23.52  LDD0243  [4]
CY4
 Probe Info  		6.69  LDD0244  [4]
N1
 Probe Info  		5.50  LDD0242  [4]
TH211
 Probe Info  		Y30(20.00); Y304(20.00); Y308(20.00); Y47(15.10)  LDD0257  [5]
TH214
 Probe Info  		Y30(20.00); Y173(14.16); Y47(11.43); Y468(5.55)  LDD0258  [5]
TH216
 Probe Info  		Y242(20.00); Y30(20.00); Y304(20.00); Y426(20.00)  LDD0259  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
AZ-9
 Probe Info  		D247(10.00)  LDD2209  [7]
ONAyne
 Probe Info  		K440(0.00); K400(0.00); K318(0.00); K20(0.00)  LDD0273  [8]
OPA-S-S-alkyne
 Probe Info  		K37(1.60); K20(2.11); K440(2.29); K318(2.44)  LDD3494  [9]
Probe 1
 Probe Info  		Y47(26.61); Y173(39.46); Y304(1.85); Y468(10.83)  LDD3495  [10]
JZ128-DTB
 Probe Info  		C148(0.00); C430(0.00)  LDD0462  [11]
THZ1-DTB
 Probe Info  		C244(1.11); C148(1.07); C149(1.05)  LDD0460  [11]
DA-P3
 Probe Info  		4.14  LDD0183  [12]
AHL-Pu-1
 Probe Info  		C430(2.82); C36(3.95)  LDD0168  [13]
EA-probe
 Probe Info  		C244(0.77)  LDD2210  [14]
HHS-482
 Probe Info  		Y30(1.02); Y304(0.47); Y426(1.09); Y436(0.63)  LDD0285  [15]
HHS-475
 Probe Info  		Y436(0.92); Y426(0.92)  LDD0264  [16]
HHS-465
 Probe Info  		Y173(6.75); Y30(10.00); Y351(7.94); Y426(10.00)  LDD2237  [17]
DBIA
 Probe Info  		C244(1.02); C149(0.91)  LDD0078  [18]
5E-2FA
 Probe Info  		H21(0.00); H80(0.00); H219(0.00); H196(0.00)  LDD2235  [19]
AMP probe
 Probe Info  		K400(0.00); K20(0.00); K326(0.00)  LDD0200  [20]
ATP probe
 Probe Info  		K400(0.00); K20(0.00); K326(0.00); K466(0.00)  LDD0199  [20]
4-Iodoacetamidophenylacetylene
 Probe Info  		C244(0.00); C136(0.00); C187(0.00); C347(0.00)  LDD0038  [21]
IA-alkyne
 Probe Info  		C187(0.00); C136(0.00); C148(0.00); C244(0.00)  LDD0032  [22]
IPIAA_H
 Probe Info  		C187(0.00); C430(0.00); C244(0.00)  LDD0030  [23]
IPIAA_L
 Probe Info  		C187(0.00); C136(0.00); C347(0.00); C430(0.00)  LDD0031  [23]
Lodoacetamide azide
 Probe Info  		C244(0.00); C136(0.00); C187(0.00); C347(0.00)  LDD0037  [21]
ATP probe
 Probe Info  		N.A.  LDD0035  [24]
BTD
 Probe Info  		N.A.  LDD0004  [25]
JW-RF-010
 Probe Info  		C148(0.00); C244(0.00); C430(0.00); C149(0.00)  LDD0026  [26]
NAIA_4
 Probe Info  		C36(0.00); C149(0.00); C187(0.00); C244(0.00)  LDD2226  [27]
TFBX
 Probe Info  		C148(0.00); C244(0.00); C149(0.00); C36(0.00)  LDD0027  [26]
WYneN
 Probe Info  		N.A.  LDD0021  [25]
WYneO
 Probe Info  		N.A.  LDD0022  [25]
1d-yne
 Probe Info  		N.A.  LDD0356  [28]
Compound 10
 Probe Info  		C148(0.00); C149(0.00); C244(0.00); C430(0.00)  LDD2216  [29]
Compound 11
 Probe Info  		C148(0.00); C149(0.00); C244(0.00); C430(0.00)  LDD2213  [29]
ENE
 Probe Info  		N.A.  LDD0006  [25]
IPM
 Probe Info  		C149(0.00); C244(0.00); C136(0.00); C36(0.00)  LDD0005  [25]
NHS
 Probe Info  		K466(0.00); K400(0.00); K459(0.00); K528(0.00)  LDD0010  [25]
OSF
 Probe Info  		N.A.  LDD0029  [30]
PF-06672131
 Probe Info  		C36(0.00); C244(0.00); C430(0.00)  LDD0017  [31]
SF
 Probe Info  		K466(0.00); K225(0.00); K400(0.00); K20(0.00)  LDD0028  [30]
STPyne
 Probe Info  		K466(0.00); K20(0.00); K367(0.00); K400(0.00)  LDD0009  [25]
VSF
 Probe Info  		C148(0.00); C244(0.00); C149(0.00)  LDD0007  [25]
YN-1
 Probe Info  		N.A.  LDD0446  [6]
Phosphinate-6
 Probe Info  		C430(0.00); C149(0.00); C244(0.00); C36(0.00)  LDD0018  [32]
Ox-W18
 Probe Info  		W506(0.00); W542(0.00)  LDD2175  [33]
1c-yne
 Probe Info  		K528(0.00); K62(0.00); K171(0.00); K270(0.00)  LDD0228  [28]
Acrolein
 Probe Info  		C430(0.00); H21(0.00); C148(0.00); C244(0.00)  LDD0217  [34]
Crotonaldehyde
 Probe Info  		H471(0.00); H21(0.00); C36(0.00)  LDD0219  [34]
Methacrolein
 Probe Info  		C148(0.00); H471(0.00); C36(0.00)  LDD0218  [34]
W1
 Probe Info  		C244(0.00); C149(0.00); C148(0.00); C430(0.00)  LDD0236  [35]
AOyne
 Probe Info  		9.80  LDD0443  [36]
NAIA_5
 Probe Info  		C149(0.00); C148(0.00); C36(0.00); C244(0.00)  LDD2223  [27]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		5.63  LDD0475  [37]
FFF probe3
 Probe Info  		5.48  LDD0465  [37]
JN0003
 Probe Info  		6.30  LDD0469  [37]
STS-2
 Probe Info  		4.58  LDD0138  [38]
VE-P
 Probe Info  		N.A.  LDD0396  [39]
Diazir
 Probe Info  		N.A.  LDD0011  [25]
STS-1
 Probe Info  		N.A.  LDD0069  [40]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C244(0.91); C430(0.63); C149(0.68)  LDD2142  [41]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C244(1.12); C430(0.99); C149(0.65)  LDD2112  [41]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C244(0.66); C430(0.63)  LDD2095  [41]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C244(0.93); C430(0.76); C36(0.81)  LDD2130  [41]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C244(1.21); C430(1.31); C36(1.20); C148(0.81)  LDD2117  [41]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C36(1.74); C148(1.21)  LDD2152  [41]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C244(0.59); C430(0.53); C36(0.64)  LDD2132  [41]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C244(0.72); C430(0.68); C36(0.68); C149(0.98)  LDD2131  [41]
 LDCM0025  4SU-RNA HEK-293T C430(2.82); C36(3.95)  LDD0168  [13]
 LDCM0026  4SU-RNA+native RNA HEK-293T C430(4.11); C36(6.11); C244(2.15)  LDD0169  [13]
 LDCM0214  AC1 HCT 116 C136(0.64); C148(0.87); C149(1.04); C244(1.12)  LDD0531  [18]
 LDCM0215  AC10 HCT 116 C136(0.61); C148(0.71); C149(1.26); C244(1.16)  LDD0532  [18]
 LDCM0216  AC100 HCT 116 C136(0.42); C148(0.61); C149(0.62); C244(0.94)  LDD0533  [18]
 LDCM0217  AC101 HCT 116 C136(0.34); C148(0.57); C149(0.60); C244(0.94)  LDD0534  [18]
 LDCM0218  AC102 HCT 116 C136(0.41); C148(0.68); C149(0.70); C244(1.01)  LDD0535  [18]
 LDCM0219  AC103 HCT 116 C136(0.34); C148(0.55); C149(0.58); C244(1.12)  LDD0536  [18]
 LDCM0220  AC104 HCT 116 C136(0.38); C148(0.59); C149(0.66); C244(1.04)  LDD0537  [18]
 LDCM0221  AC105 HCT 116 C136(0.47); C148(0.62); C149(0.63); C244(1.05)  LDD0538  [18]
 LDCM0222  AC106 HCT 116 C136(0.31); C148(0.59); C149(0.59); C244(1.05)  LDD0539  [18]
 LDCM0223  AC107 HCT 116 C136(0.42); C148(0.57); C149(0.63); C244(1.31)  LDD0540  [18]
 LDCM0224  AC108 HCT 116 C136(0.40); C148(0.66); C149(0.71); C244(0.89)  LDD0541  [18]
 LDCM0225  AC109 HCT 116 C136(0.32); C148(0.74); C149(0.78); C244(0.93)  LDD0542  [18]
 LDCM0226  AC11 HCT 116 C136(0.56); C148(0.65); C149(1.25); C244(1.12)  LDD0543  [18]
 LDCM0227  AC110 HCT 116 C136(0.26); C148(0.66); C149(0.69); C244(0.96)  LDD0544  [18]
 LDCM0228  AC111 HCT 116 C136(0.29); C148(0.67); C149(0.71); C244(0.96)  LDD0545  [18]
 LDCM0229  AC112 HCT 116 C136(0.30); C148(0.52); C149(0.63); C244(1.10)  LDD0546  [18]
 LDCM0230  AC113 HCT 116 C136(0.85); C148(1.20); C149(1.05); C244(0.97)  LDD0547  [18]
 LDCM0231  AC114 HCT 116 C136(0.76); C148(0.78); C149(0.91); C244(1.04)  LDD0548  [18]
 LDCM0232  AC115 HCT 116 C136(0.81); C148(0.86); C149(0.97); C244(1.15)  LDD0549  [18]
 LDCM0233  AC116 HCT 116 C136(0.52); C148(0.68); C149(0.79); C244(1.14)  LDD0550  [18]
 LDCM0234  AC117 HCT 116 C136(0.67); C148(0.67); C149(0.88); C244(1.11)  LDD0551  [18]
 LDCM0235  AC118 HCT 116 C136(0.65); C148(0.67); C149(0.81); C244(1.04)  LDD0552  [18]
 LDCM0236  AC119 HCT 116 C136(0.65); C148(0.71); C149(0.82); C244(1.08)  LDD0553  [18]
 LDCM0237  AC12 HCT 116 C136(0.84); C148(0.81); C149(1.07); C244(1.17)  LDD0554  [18]
 LDCM0238  AC120 HCT 116 C136(0.60); C148(0.73); C149(0.87); C244(1.08)  LDD0555  [18]
 LDCM0239  AC121 HCT 116 C136(0.66); C148(0.73); C149(0.85); C244(1.02)  LDD0556  [18]
 LDCM0240  AC122 HCT 116 C136(0.68); C148(0.86); C149(0.83); C244(1.06)  LDD0557  [18]
 LDCM0241  AC123 HCT 116 C136(0.80); C148(0.90); C149(1.05); C244(1.03)  LDD0558  [18]
 LDCM0242  AC124 HCT 116 C136(1.00); C148(1.06); C149(1.13); C244(1.01)  LDD0559  [18]
 LDCM0243  AC125 HCT 116 C136(0.59); C148(0.73); C149(0.82); C244(1.10)  LDD0560  [18]
 LDCM0244  AC126 HCT 116 C136(0.68); C148(0.76); C149(0.79); C244(1.09)  LDD0561  [18]
 LDCM0245  AC127 HCT 116 C136(0.64); C148(0.75); C149(0.80); C244(1.12)  LDD0562  [18]
 LDCM0246  AC128 HCT 116 C148(1.03); C149(1.04); C244(1.10); C430(0.92)  LDD0563  [18]
 LDCM0247  AC129 HCT 116 C148(1.35); C149(1.26); C244(1.03); C430(1.01)  LDD0564  [18]
 LDCM0249  AC130 HCT 116 C148(0.99); C149(0.98); C244(1.11); C430(0.88)  LDD0566  [18]
 LDCM0250  AC131 HCT 116 C148(1.01); C149(1.00); C244(0.95); C430(0.88)  LDD0567  [18]
 LDCM0251  AC132 HCT 116 C148(1.35); C149(1.16); C244(0.97); C430(1.21)  LDD0568  [18]
 LDCM0252  AC133 HCT 116 C148(0.93); C149(0.95); C244(1.11); C430(0.82)  LDD0569  [18]
 LDCM0253  AC134 HCT 116 C148(0.95); C149(0.95); C244(1.15); C430(0.80)  LDD0570  [18]
 LDCM0254  AC135 HCT 116 C148(0.78); C149(0.84); C244(1.12); C430(0.75)  LDD0571  [18]
 LDCM0255  AC136 HCT 116 C148(0.91); C149(0.88); C244(1.04); C430(0.74)  LDD0572  [18]
 LDCM0256  AC137 HCT 116 C148(1.19); C149(1.14); C244(1.10); C430(1.04)  LDD0573  [18]
 LDCM0257  AC138 HCT 116 C148(0.75); C149(0.76); C244(1.20); C430(0.72)  LDD0574  [18]
 LDCM0258  AC139 HCT 116 C148(0.88); C149(0.80); C244(1.12); C430(0.77)  LDD0575  [18]
 LDCM0259  AC14 HCT 116 C136(0.71); C148(0.81); C149(1.06); C244(1.17)  LDD0576  [18]
 LDCM0260  AC140 HCT 116 C148(0.85); C149(0.79); C244(1.25); C430(0.71)  LDD0577  [18]
 LDCM0261  AC141 HCT 116 C148(0.83); C149(0.79); C244(1.20); C430(0.76)  LDD0578  [18]
 LDCM0262  AC142 HCT 116 C148(0.94); C149(0.87); C244(1.07); C430(0.74)  LDD0579  [18]
 LDCM0263  AC143 HCT 116 C136(0.39); C148(0.74); C149(0.82); C244(1.05)  LDD0580  [18]
 LDCM0264  AC144 HCT 116 C136(0.42); C430(0.52); C148(0.71); C149(0.79)  LDD0581  [18]
 LDCM0265  AC145 HCT 116 C136(0.55); C430(0.57); C148(0.88); C149(0.91)  LDD0582  [18]
 LDCM0266  AC146 HCT 116 C136(0.41); C430(0.48); C148(0.76); C149(0.82)  LDD0583  [18]
 LDCM0267  AC147 HCT 116 C136(0.61); C430(0.73); C148(0.87); C149(0.98)  LDD0584  [18]
 LDCM0268  AC148 HCT 116 C136(0.32); C430(0.51); C148(0.76); C149(0.99)  LDD0585  [18]
 LDCM0269  AC149 HCT 116 C136(0.32); C430(0.45); C148(0.65); C149(0.74)  LDD0586  [18]
 LDCM0270  AC15 HCT 116 C148(0.78); C136(0.80); C430(0.88); C244(1.12)  LDD0587  [18]
 LDCM0271  AC150 HCT 116 C136(0.44); C430(0.57); C148(0.78); C149(0.85)  LDD0588  [18]
 LDCM0272  AC151 HCT 116 C136(0.49); C430(0.53); C148(0.70); C149(0.86)  LDD0589  [18]
 LDCM0273  AC152 HCT 116 C136(0.41); C430(0.58); C148(0.76); C149(0.97)  LDD0590  [18]
 LDCM0274  AC153 HCT 116 C136(0.27); C430(0.40); C148(0.63); C149(0.77)  LDD0591  [18]
 LDCM0621  AC154 HCT 116 C136(0.58); C148(1.01); C149(1.06); C244(1.21)  LDD2158  [18]
 LDCM0622  AC155 HCT 116 C136(0.40); C148(0.79); C149(0.82); C244(1.26)  LDD2159  [18]
 LDCM0623  AC156 HCT 116 C136(0.76); C148(0.91); C149(0.84); C244(1.09)  LDD2160  [18]
 LDCM0624  AC157 HCT 116 C136(1.04); C148(1.14); C149(1.34); C244(1.02)  LDD2161  [18]
 LDCM0276  AC17 HCT 116 C148(0.82); C136(0.85); C149(0.86); C430(0.87)  LDD0593  [18]
 LDCM0277  AC18 HCT 116 C136(0.75); C148(0.97); C149(0.99); C430(1.14)  LDD0594  [18]
 LDCM0278  AC19 HCT 116 C148(0.91); C136(0.91); C430(0.95); C149(0.98)  LDD0595  [18]
 LDCM0279  AC2 HCT 116 C148(0.88); C136(0.88); C430(0.90); C244(1.09)  LDD0596  [18]
 LDCM0280  AC20 HCT 116 C136(0.73); C148(0.77); C149(0.86); C430(0.90)  LDD0597  [18]
 LDCM0281  AC21 HCT 116 C136(0.60); C148(0.82); C149(0.89); C430(0.93)  LDD0598  [18]
 LDCM0282  AC22 HCT 116 C136(0.79); C149(0.85); C148(0.85); C430(0.90)  LDD0599  [18]
 LDCM0283  AC23 HCT 116 C136(0.76); C148(0.84); C149(0.91); C430(1.02)  LDD0600  [18]
 LDCM0284  AC24 HCT 116 C148(1.03); C244(1.04); C430(1.08); C136(1.10)  LDD0601  [18]
 LDCM0285  AC25 HCT 116 C148(0.68); C136(0.73); C149(0.85); C430(0.88)  LDD0602  [18]
 LDCM0286  AC26 HCT 116 C148(0.69); C149(0.86); C430(0.87); C136(0.89)  LDD0603  [18]
 LDCM0287  AC27 HCT 116 C148(0.57); C136(0.67); C149(0.69); C430(0.79)  LDD0604  [18]
 LDCM0288  AC28 HCT 116 C148(0.67); C149(0.84); C136(0.87); C430(0.91)  LDD0605  [18]
 LDCM0289  AC29 HCT 116 C148(0.73); C149(0.79); C430(0.82); C136(1.04)  LDD0606  [18]
 LDCM0290  AC3 HCT 116 C430(1.06); C148(1.12); C244(1.13); C149(1.16)  LDD0607  [18]
 LDCM0291  AC30 HCT 116 C148(0.59); C149(0.71); C136(0.75); C430(0.76)  LDD0608  [18]
 LDCM0292  AC31 HCT 116 C148(0.63); C136(0.67); C430(0.77); C149(0.78)  LDD0609  [18]
 LDCM0293  AC32 HCT 116 C148(0.64); C149(0.79); C430(0.85); C136(0.86)  LDD0610  [18]
 LDCM0294  AC33 HCT 116 C148(0.62); C149(0.74); C136(0.82); C430(0.86)  LDD0611  [18]
 LDCM0295  AC34 HCT 116 C148(0.60); C149(0.74); C136(0.80); C430(0.91)  LDD0612  [18]
 LDCM0296  AC35 HCT 116 C244(0.98); C149(1.06); C148(1.07); C136(1.14)  LDD0613  [18]
 LDCM0297  AC36 HCT 116 C244(1.00); C149(1.09); C148(1.09); C136(1.13)  LDD0614  [18]
 LDCM0298  AC37 HCT 116 C149(0.78); C244(0.86); C148(0.87); C136(0.93)  LDD0615  [18]
 LDCM0299  AC38 HCT 116 C244(0.90); C149(0.91); C148(1.00); C430(1.06)  LDD0616  [18]
 LDCM0300  AC39 HCT 116 C136(0.76); C148(0.78); C430(0.87); C149(0.88)  LDD0617  [18]
 LDCM0301  AC4 HCT 116 C136(0.83); C148(0.97); C430(0.97); C149(1.03)  LDD0618  [18]
 LDCM0302  AC40 HCT 116 C149(0.77); C136(0.78); C148(0.82); C430(0.88)  LDD0619  [18]
 LDCM0303  AC41 HCT 116 C149(0.88); C244(0.99); C148(1.01); C136(1.08)  LDD0620  [18]
 LDCM0304  AC42 HCT 116 C149(0.93); C244(1.02); C148(1.06); C430(1.08)  LDD0621  [18]
 LDCM0305  AC43 HCT 116 C148(0.77); C136(0.80); C149(0.81); C430(0.86)  LDD0622  [18]
 LDCM0306  AC44 HCT 116 C149(0.93); C148(0.97); C136(1.02); C244(1.07)  LDD0623  [18]
 LDCM0307  AC45 HCT 116 C149(0.76); C136(0.79); C148(0.84); C244(1.13)  LDD0624  [18]
 LDCM0308  AC46 HCT 116 C244(0.99); C430(1.09); C149(1.10); C148(1.13)  LDD0625  [18]
 LDCM0309  AC47 HCT 116 C136(0.82); C148(0.85); C149(0.89); C430(0.95)  LDD0626  [18]
 LDCM0310  AC48 HCT 116 C149(0.79); C148(0.80); C430(0.81); C136(0.95)  LDD0627  [18]
 LDCM0311  AC49 HCT 116 C148(0.81); C149(0.88); C430(0.89); C136(0.97)  LDD0628  [18]
 LDCM0312  AC5 HCT 116 C136(0.77); C148(0.88); C430(0.93); C149(1.09)  LDD0629  [18]
 LDCM0313  AC50 HCT 116 C430(0.83); C148(0.89); C149(0.94); C136(0.97)  LDD0630  [18]
 LDCM0314  AC51 HCT 116 C244(0.89); C149(1.06); C430(1.19); C148(1.26)  LDD0631  [18]
 LDCM0315  AC52 HCT 116 C136(0.80); C148(0.82); C149(0.94); C430(0.95)  LDD0632  [18]
 LDCM0316  AC53 HCT 116 C149(0.91); C148(0.91); C430(0.97); C244(1.04)  LDD0633  [18]
 LDCM0317  AC54 HCT 116 C136(0.68); C148(0.78); C430(0.80); C149(0.89)  LDD0634  [18]
 LDCM0318  AC55 HCT 116 C136(0.64); C148(0.68); C430(0.77); C149(0.78)  LDD0635  [18]
 LDCM0319  AC56 HCT 116 C148(0.60); C136(0.65); C430(0.71); C149(0.75)  LDD0636  [18]
 LDCM0320  AC57 HCT 116 C148(0.61); C149(0.67); C430(0.78); C244(1.23)  LDD0637  [18]
 LDCM0321  AC58 HCT 116 C148(0.65); C430(0.68); C149(0.70); C244(1.35)  LDD0638  [18]
 LDCM0322  AC59 HCT 116 C148(0.63); C149(0.75); C430(0.85); C244(1.37)  LDD0639  [18]
 LDCM0323  AC6 HCT 116 C148(0.66); C136(0.71); C430(0.76); C149(0.97)  LDD0640  [18]
 LDCM0324  AC60 HCT 116 C148(0.55); C149(0.71); C430(0.75); C244(1.26)  LDD0641  [18]
 LDCM0325  AC61 HCT 116 C148(0.55); C149(0.67); C430(0.78); C244(1.21)  LDD0642  [18]
 LDCM0326  AC62 HCT 116 C148(0.67); C149(0.76); C430(0.85); C244(1.52)  LDD0643  [18]
 LDCM0327  AC63 HCT 116 C148(0.58); C149(0.64); C430(0.86); C244(1.24)  LDD0644  [18]
 LDCM0328  AC64 HCT 116 C148(0.57); C149(0.74); C430(0.75); C244(1.41)  LDD0645  [18]
 LDCM0329  AC65 HCT 116 C148(0.53); C430(0.69); C149(0.70); C244(1.51)  LDD0646  [18]
 LDCM0330  AC66 HCT 116 C148(0.56); C430(0.65); C149(0.73); C244(1.48)  LDD0647  [18]
 LDCM0331  AC67 HCT 116 C148(0.44); C149(0.62); C430(0.73); C244(1.43)  LDD0648  [18]
 LDCM0332  AC68 HCT 116 C430(0.79); C148(0.97); C136(1.02); C149(1.05)  LDD0649  [18]
 LDCM0333  AC69 HCT 116 C430(0.74); C136(0.80); C149(0.83); C148(0.85)  LDD0650  [18]
 LDCM0334  AC7 HCT 116 C136(0.64); C148(0.67); C430(0.81); C244(1.05)  LDD0651  [18]
 LDCM0335  AC70 HCT 116 C430(0.69); C136(0.80); C149(0.85); C148(0.86)  LDD0652  [18]
 LDCM0336  AC71 HCT 116 C430(0.80); C244(0.90); C149(1.07); C148(1.15)  LDD0653  [18]
 LDCM0337  AC72 HCT 116 C430(0.68); C149(0.86); C136(0.90); C148(0.95)  LDD0654  [18]
 LDCM0338  AC73 HCT 116 C430(0.55); C136(0.61); C149(0.65); C148(0.74)  LDD0655  [18]
 LDCM0339  AC74 HCT 116 C136(0.48); C430(0.55); C149(0.57); C148(0.69)  LDD0656  [18]
 LDCM0340  AC75 HCT 116 C430(0.51); C136(0.51); C149(0.65); C148(0.67)  LDD0657  [18]
 LDCM0341  AC76 HCT 116 C430(0.83); C149(0.93); C148(0.95); C136(0.96)  LDD0658  [18]
 LDCM0342  AC77 HCT 116 C430(0.64); C148(0.77); C149(0.81); C136(0.84)  LDD0659  [18]
 LDCM0343  AC78 HCT 116 C430(0.61); C136(0.66); C149(0.71); C148(0.76)  LDD0660  [18]
 LDCM0344  AC79 HCT 116 C136(0.79); C149(0.85); C430(0.87); C148(0.93)  LDD0661  [18]
 LDCM0345  AC8 HCT 116 C136(0.66); C148(0.72); C430(0.87); C149(1.09)  LDD0662  [18]
 LDCM0346  AC80 HCT 116 C149(0.83); C148(0.84); C430(0.97); C136(0.99)  LDD0663  [18]
 LDCM0347  AC81 HCT 116 C136(0.65); C148(0.94); C244(0.94); C149(0.97)  LDD0664  [18]
 LDCM0348  AC82 HCT 116 C136(0.34); C430(0.49); C149(0.56); C148(0.58)  LDD0665  [18]
 LDCM0349  AC83 HCT 116 C430(0.76); C136(0.79); C148(0.90); C244(0.99)  LDD0666  [18]
 LDCM0350  AC84 HCT 116 C136(0.83); C430(0.94); C244(1.00); C148(1.02)  LDD0667  [18]
 LDCM0351  AC85 HCT 116 C430(0.80); C244(0.95); C148(0.99); C149(1.04)  LDD0668  [18]
 LDCM0352  AC86 HCT 116 C430(0.87); C244(1.03); C149(1.14); C136(1.16)  LDD0669  [18]
 LDCM0353  AC87 HCT 116 C244(0.87); C430(0.93); C136(1.00); C149(1.10)  LDD0670  [18]
 LDCM0354  AC88 HCT 116 C244(0.96); C149(1.20); C136(1.23); C148(1.41)  LDD0671  [18]
 LDCM0355  AC89 HCT 116 C244(0.97); C149(0.99); C430(1.13); C148(1.15)  LDD0672  [18]
 LDCM0357  AC90 HCT 116 C430(0.91); C244(0.96); C149(0.99); C148(1.39)  LDD0674  [18]
 LDCM0358  AC91 HCT 116 C136(0.88); C430(0.91); C148(0.98); C244(1.00)  LDD0675  [18]
 LDCM0359  AC92 HCT 116 C149(0.91); C430(0.98); C244(1.00); C136(1.01)  LDD0676  [18]
 LDCM0360  AC93 HCT 116 C244(0.97); C149(0.97); C430(1.01); C148(1.19)  LDD0677  [18]
 LDCM0361  AC94 HCT 116 C244(0.94); C430(1.28); C149(1.30); C136(1.38)  LDD0678  [18]
 LDCM0362  AC95 HCT 116 C244(0.85); C430(0.94); C136(0.96); C149(1.10)  LDD0679  [18]
 LDCM0363  AC96 HCT 116 C136(0.87); C244(0.96); C149(0.96); C430(1.12)  LDD0680  [18]
 LDCM0364  AC97 HCT 116 C430(0.84); C244(0.98); C149(1.03); C148(1.05)  LDD0681  [18]
 LDCM0365  AC98 HCT 116 C136(0.09); C430(0.31); C148(0.35); C149(0.45)  LDD0682  [18]
 LDCM0366  AC99 HCT 116 C136(0.43); C149(0.74); C148(0.74); C430(0.76)  LDD0683  [18]
 LDCM0545  Acetamide MDA-MB-231 C36(0.55); C148(0.83)  LDD2138  [41]
 LDCM0520  AKOS000195272 MDA-MB-231 C244(0.85); C36(0.75); C149(0.96)  LDD2113  [41]
 LDCM0248  AKOS034007472 HCT 116 C136(0.63); C148(0.68); C149(1.05); C244(1.05)  LDD0565  [18]
 LDCM0356  AKOS034007680 HCT 116 C136(0.47); C148(0.60); C430(0.71); C149(1.05)  LDD0673  [18]
 LDCM0275  AKOS034007705 HCT 116 C136(0.48); C148(0.60); C430(0.61); C149(0.99)  LDD0592  [18]
 LDCM0156  Aniline NCI-H1299 C430(0.00); C149(0.00); C244(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C244(1.02); C149(0.91)  LDD0078  [18]
 LDCM0498  BS-3668 MDA-MB-231 C244(0.87); C430(0.64); C36(0.63); C149(0.75)  LDD2091  [41]
 LDCM0630  CCW28-3 231MFP C149(1.65); C244(1.48)  LDD2214  [42]
 LDCM0108  Chloroacetamide HeLa C187(0.00); H471(0.00); H21(0.00); C244(0.00)  LDD0222  [34]
 LDCM0632  CL-Sc Hep-G2 C430(7.83); C36(0.99); C36(0.86); C244(0.52)  LDD2227  [27]
 LDCM0367  CL1 HCT 116 C244(0.83); C149(0.93); C430(0.98); C136(0.99)  LDD0684  [18]
 LDCM0368  CL10 HCT 116 C149(0.75); C148(0.77); C136(0.77); C430(0.86)  LDD0685  [18]
 LDCM0369  CL100 HCT 116 C136(0.92); C430(0.99); C148(1.03); C149(1.12)  LDD0686  [18]
 LDCM0370  CL101 HCT 116 C136(0.48); C148(0.60); C430(0.64); C149(0.99)  LDD0687  [18]
 LDCM0371  CL102 HCT 116 C136(0.77); C430(0.78); C148(0.82); C244(1.09)  LDD0688  [18]
 LDCM0372  CL103 HCT 116 C136(0.60); C430(0.79); C148(0.87); C244(0.95)  LDD0689  [18]
 LDCM0373  CL104 HCT 116 C136(0.60); C148(0.73); C430(0.73); C244(1.03)  LDD0690  [18]
 LDCM0374  CL105 HCT 116 C136(0.51); C148(0.69); C149(0.77); C430(0.79)  LDD0691  [18]
 LDCM0375  CL106 HCT 116 C136(0.42); C148(0.66); C430(0.76); C149(0.79)  LDD0692  [18]
 LDCM0376  CL107 HCT 116 C136(0.62); C148(0.81); C149(0.85); C430(0.94)  LDD0693  [18]
 LDCM0377  CL108 HCT 116 C136(0.84); C148(0.84); C149(0.93); C430(0.95)  LDD0694  [18]
 LDCM0378  CL109 HCT 116 C148(0.79); C136(0.89); C149(0.89); C430(0.92)  LDD0695  [18]
 LDCM0379  CL11 HCT 116 C148(0.70); C136(0.72); C149(0.81); C430(0.83)  LDD0696  [18]
 LDCM0380  CL110 HCT 116 C136(0.82); C148(0.84); C430(0.87); C149(0.93)  LDD0697  [18]
 LDCM0381  CL111 HCT 116 C136(0.76); C148(0.78); C149(0.80); C430(0.90)  LDD0698  [18]
 LDCM0382  CL112 HCT 116 C244(0.97); C136(1.00); C148(1.01); C430(1.04)  LDD0699  [18]
 LDCM0383  CL113 HCT 116 C148(0.65); C136(0.83); C149(0.84); C430(0.86)  LDD0700  [18]
 LDCM0384  CL114 HCT 116 C148(0.65); C149(0.66); C430(0.75); C136(0.83)  LDD0701  [18]
 LDCM0385  CL115 HCT 116 C148(0.57); C136(0.67); C430(0.75); C149(0.78)  LDD0702  [18]
 LDCM0386  CL116 HCT 116 C148(0.60); C136(0.68); C149(0.74); C430(0.84)  LDD0703  [18]
 LDCM0387  CL117 HCT 116 C136(0.62); C148(0.72); C430(0.72); C149(0.98)  LDD0704  [18]
 LDCM0388  CL118 HCT 116 C148(0.93); C149(0.94); C244(1.00); C136(1.04)  LDD0705  [18]
 LDCM0389  CL119 HCT 116 C148(0.74); C149(0.80); C136(0.81); C430(1.02)  LDD0706  [18]
 LDCM0390  CL12 HCT 116 C149(0.76); C148(0.76); C430(0.82); C136(0.85)  LDD0707  [18]
 LDCM0391  CL120 HCT 116 C149(0.72); C148(0.76); C136(0.79); C430(1.01)  LDD0708  [18]
 LDCM0392  CL121 HCT 116 C430(0.78); C149(0.89); C148(0.98); C244(1.03)  LDD0709  [18]
 LDCM0393  CL122 HCT 116 C148(0.69); C136(0.70); C430(0.78); C149(0.82)  LDD0710  [18]
 LDCM0394  CL123 HCT 116 C136(0.78); C148(0.86); C149(0.90); C430(0.97)  LDD0711  [18]
 LDCM0395  CL124 HCT 116 C136(0.72); C148(0.73); C430(0.79); C149(0.87)  LDD0712  [18]
 LDCM0396  CL125 HCT 116 C148(0.64); C149(0.73); C430(0.84); C244(1.10)  LDD0713  [18]
 LDCM0397  CL126 HCT 116 C148(0.74); C430(0.84); C149(0.86); C244(1.13)  LDD0714  [18]
 LDCM0398  CL127 HCT 116 C148(0.68); C149(0.81); C430(0.91); C244(1.12)  LDD0715  [18]
 LDCM0399  CL128 HCT 116 C148(0.58); C149(0.68); C430(0.71); C244(1.31)  LDD0716  [18]
 LDCM0400  CL13 HCT 116 C136(0.72); C149(0.72); C430(0.75); C148(0.76)  LDD0717  [18]
 LDCM0401  CL14 HCT 116 C149(0.85); C244(0.95); C148(1.08); C136(1.14)  LDD0718  [18]
 LDCM0402  CL15 HCT 116 C430(0.67); C136(0.75); C148(0.75); C149(0.82)  LDD0719  [18]
 LDCM0403  CL16 HCT 116 C149(0.57); C148(0.62); C136(0.70); C430(0.78)  LDD0720  [18]
 LDCM0404  CL17 HCT 116 C136(0.59); C149(0.69); C148(0.76); C430(0.82)  LDD0721  [18]
 LDCM0405  CL18 HCT 116 C136(0.52); C149(0.56); C148(0.61); C430(0.67)  LDD0722  [18]
 LDCM0406  CL19 HCT 116 C136(0.57); C149(0.61); C148(0.62); C430(0.73)  LDD0723  [18]
 LDCM0407  CL2 HCT 116 C244(0.90); C149(0.94); C430(1.18); C148(1.21)  LDD0724  [18]
 LDCM0408  CL20 HCT 116 C149(0.62); C136(0.63); C148(0.65); C430(0.73)  LDD0725  [18]
 LDCM0409  CL21 HCT 116 C136(0.44); C149(0.60); C148(0.61); C430(0.62)  LDD0726  [18]
 LDCM0410  CL22 HCT 116 C136(0.46); C148(0.60); C149(0.61); C430(0.68)  LDD0727  [18]
 LDCM0411  CL23 HCT 116 C149(0.76); C148(0.76); C136(0.96); C430(1.03)  LDD0728  [18]
 LDCM0412  CL24 HCT 116 C148(0.67); C149(0.70); C136(0.80); C430(0.81)  LDD0729  [18]
 LDCM0413  CL25 HCT 116 C136(0.60); C148(0.60); C149(0.56); C244(1.28)  LDD0730  [18]
 LDCM0414  CL26 HCT 116 C136(1.02); C148(0.76); C149(0.79); C244(1.09)  LDD0731  [18]
 LDCM0415  CL27 HCT 116 C136(0.66); C148(0.62); C149(0.60); C244(1.16)  LDD0732  [18]
 LDCM0416  CL28 HCT 116 C136(0.59); C148(0.56); C149(0.57); C244(1.15)  LDD0733  [18]
 LDCM0417  CL29 HCT 116 C136(0.50); C148(0.55); C149(0.57); C244(1.22)  LDD0734  [18]
 LDCM0418  CL3 HCT 116 C136(1.60); C148(1.29); C149(1.05); C244(0.90)  LDD0735  [18]
 LDCM0419  CL30 HCT 116 C136(0.55); C148(0.67); C149(0.63); C244(1.09)  LDD0736  [18]
 LDCM0420  CL31 HCT 116 C136(0.91); C148(1.19); C149(1.10); C244(1.09)  LDD0737  [18]
 LDCM0421  CL32 HCT 116 C136(0.66); C148(0.93); C149(0.74); C244(1.24)  LDD0738  [18]
 LDCM0422  CL33 HCT 116 C136(0.94); C148(1.00); C149(0.89); C244(1.26)  LDD0739  [18]
 LDCM0423  CL34 HCT 116 C136(0.66); C148(0.96); C149(0.90); C244(1.34)  LDD0740  [18]
 LDCM0424  CL35 HCT 116 C136(1.01); C148(1.20); C149(0.96); C244(1.31)  LDD0741  [18]
 LDCM0425  CL36 HCT 116 C136(1.03); C148(1.24); C149(1.16); C244(1.39)  LDD0742  [18]
 LDCM0426  CL37 HCT 116 C136(0.84); C148(1.02); C149(0.98); C244(1.44)  LDD0743  [18]
 LDCM0428  CL39 HCT 116 C136(0.64); C148(0.92); C149(0.82); C244(1.37)  LDD0745  [18]
 LDCM0429  CL4 HCT 116 C136(1.28); C148(1.22); C149(1.09); C244(0.96)  LDD0746  [18]
 LDCM0430  CL40 HCT 116 C136(0.75); C148(0.96); C149(0.83); C244(1.29)  LDD0747  [18]
 LDCM0431  CL41 HCT 116 C136(1.29); C148(1.40); C149(1.23); C244(1.34)  LDD0748  [18]
 LDCM0432  CL42 HCT 116 C136(0.49); C148(0.86); C149(0.71); C244(1.71)  LDD0749  [18]
 LDCM0433  CL43 HCT 116 C136(0.80); C148(1.00); C149(0.86); C244(1.46)  LDD0750  [18]
 LDCM0434  CL44 HCT 116 C136(0.68); C148(0.88); C149(0.77); C244(1.23)  LDD0751  [18]
 LDCM0435  CL45 HCT 116 C136(0.64); C148(0.79); C149(0.72); C244(1.22)  LDD0752  [18]
 LDCM0436  CL46 HCT 116 C148(1.13); C149(0.88); C244(0.85); C430(1.29)  LDD0753  [18]
 LDCM0437  CL47 HCT 116 C148(1.13); C149(1.07); C244(0.86); C430(1.30)  LDD0754  [18]
 LDCM0438  CL48 HCT 116 C148(1.74); C149(1.37); C244(0.94); C430(1.60)  LDD0755  [18]
 LDCM0439  CL49 HCT 116 C148(1.15); C149(1.05); C244(0.90); C430(1.14)  LDD0756  [18]
 LDCM0440  CL5 HCT 116 C136(1.05); C148(1.07); C149(0.95); C244(0.95)  LDD0757  [18]
 LDCM0441  CL50 HCT 116 C148(1.38); C149(1.08); C244(0.95); C430(1.43)  LDD0758  [18]
 LDCM0442  CL51 HCT 116 C148(1.15); C149(0.94); C244(0.88); C430(1.16)  LDD0759  [18]
 LDCM0443  CL52 HCT 116 C148(0.99); C149(0.88); C244(0.87); C430(1.13)  LDD0760  [18]
 LDCM0444  CL53 HCT 116 C148(1.29); C149(1.04); C244(0.90); C430(1.35)  LDD0761  [18]
 LDCM0445  CL54 HCT 116 C148(1.78); C149(1.24); C244(0.88); C430(1.38)  LDD0762  [18]
 LDCM0446  CL55 HCT 116 C148(1.37); C149(1.14); C244(0.80); C430(1.39)  LDD0763  [18]
 LDCM0447  CL56 HCT 116 C148(1.00); C149(0.98); C244(0.85); C430(1.20)  LDD0764  [18]
 LDCM0448  CL57 HCT 116 C148(1.25); C149(1.03); C244(0.95); C430(1.26)  LDD0765  [18]
 LDCM0449  CL58 HCT 116 C148(1.07); C149(0.96); C244(0.92); C430(1.19)  LDD0766  [18]
 LDCM0450  CL59 HCT 116 C148(1.46); C149(1.14); C244(0.88); C430(1.53)  LDD0767  [18]
 LDCM0451  CL6 HCT 116 C136(0.87); C148(0.82); C149(0.78); C244(0.97)  LDD0768  [18]
 LDCM0452  CL60 HCT 116 C148(1.38); C149(1.14); C244(0.92); C430(1.31)  LDD0769  [18]
 LDCM0453  CL61 HCT 116 C136(1.11); C148(0.94); C149(0.94); C244(1.05)  LDD0770  [18]
 LDCM0454  CL62 HCT 116 C136(1.32); C148(1.39); C149(1.25); C244(1.19)  LDD0771  [18]
 LDCM0455  CL63 HCT 116 C136(0.85); C148(0.91); C149(0.90); C244(1.29)  LDD0772  [18]
 LDCM0456  CL64 HCT 116 C136(0.73); C148(0.78); C149(0.79); C244(1.13)  LDD0773  [18]
 LDCM0457  CL65 HCT 116 C136(0.86); C148(0.91); C149(0.92); C244(1.18)  LDD0774  [18]
 LDCM0458  CL66 HCT 116 C136(0.75); C148(0.81); C149(0.83); C244(1.67)  LDD0775  [18]
 LDCM0459  CL67 HCT 116 C136(0.86); C148(0.90); C149(0.93); C244(1.14)  LDD0776  [18]
 LDCM0460  CL68 HCT 116 C136(0.79); C148(0.91); C149(0.99); C244(1.28)  LDD0777  [18]
 LDCM0461  CL69 HCT 116 C136(0.74); C148(0.68); C149(0.77); C244(1.48)  LDD0778  [18]
 LDCM0462  CL7 HCT 116 C136(0.93); C148(0.90); C149(0.82); C244(1.17)  LDD0779  [18]
 LDCM0463  CL70 HCT 116 C136(0.91); C148(0.93); C149(0.97); C244(1.20)  LDD0780  [18]
 LDCM0464  CL71 HCT 116 C136(0.78); C148(0.84); C149(0.87); C244(1.03)  LDD0781  [18]
 LDCM0465  CL72 HCT 116 C136(0.72); C148(0.78); C149(0.82); C244(1.20)  LDD0782  [18]
 LDCM0466  CL73 HCT 116 C136(0.76); C148(0.77); C149(0.80); C244(1.85)  LDD0783  [18]
 LDCM0467  CL74 HCT 116 C136(0.92); C148(0.95); C149(0.96); C244(1.42)  LDD0784  [18]
 LDCM0469  CL76 HCT 116 C136(0.55); C148(0.65); C149(0.76); C244(0.99)  LDD0786  [18]
 LDCM0470  CL77 HCT 116 C136(0.75); C148(0.83); C149(0.92); C244(1.27)  LDD0787  [18]
 LDCM0471  CL78 HCT 116 C136(0.54); C148(0.78); C149(0.86); C244(1.09)  LDD0788  [18]
 LDCM0472  CL79 HCT 116 C136(0.76); C148(0.82); C149(0.98); C244(1.15)  LDD0789  [18]
 LDCM0473  CL8 HCT 116 C136(0.85); C148(0.78); C149(0.79); C244(1.28)  LDD0790  [18]
 LDCM0474  CL80 HCT 116 C136(0.50); C148(0.76); C149(0.81); C244(1.03)  LDD0791  [18]
 LDCM0475  CL81 HCT 116 C136(0.67); C148(0.86); C149(0.96); C244(1.03)  LDD0792  [18]
 LDCM0476  CL82 HCT 116 C136(0.55); C148(0.84); C149(1.00); C244(1.23)  LDD0793  [18]
 LDCM0477  CL83 HCT 116 C136(0.60); C148(0.74); C149(0.83); C244(1.20)  LDD0794  [18]
 LDCM0478  CL84 HCT 116 C136(0.45); C148(0.64); C149(0.81); C244(1.32)  LDD0795  [18]
 LDCM0479  CL85 HCT 116 C136(0.72); C148(0.73); C149(0.79); C244(1.10)  LDD0796  [18]
 LDCM0480  CL86 HCT 116 C136(0.72); C148(0.80); C149(0.91); C244(1.04)  LDD0797  [18]
 LDCM0481  CL87 HCT 116 C136(0.67); C148(0.71); C149(0.77); C244(1.10)  LDD0798  [18]
 LDCM0482  CL88 HCT 116 C136(0.70); C148(0.79); C149(0.86); C244(1.20)  LDD0799  [18]
 LDCM0483  CL89 HCT 116 C136(0.35); C148(0.64); C149(0.79); C244(1.33)  LDD0800  [18]
 LDCM0484  CL9 HCT 116 C136(1.24); C148(0.92); C149(0.83); C244(1.06)  LDD0801  [18]
 LDCM0485  CL90 HCT 116 C136(1.06); C148(1.06); C149(1.15); C244(0.96)  LDD0802  [18]
 LDCM0486  CL91 HCT 116 C136(0.84); C148(0.97); C149(1.10); C244(1.13)  LDD0803  [18]
 LDCM0487  CL92 HCT 116 C136(0.80); C148(0.90); C149(1.02); C244(1.05)  LDD0804  [18]
 LDCM0488  CL93 HCT 116 C136(0.67); C148(0.82); C149(0.91); C244(1.12)  LDD0805  [18]
 LDCM0489  CL94 HCT 116 C136(0.88); C148(1.02); C149(1.06); C244(1.13)  LDD0806  [18]
 LDCM0490  CL95 HCT 116 C136(0.67); C148(0.87); C149(0.97); C244(1.09)  LDD0807  [18]
 LDCM0491  CL96 HCT 116 C136(0.66); C148(0.78); C149(0.96); C244(1.00)  LDD0808  [18]
 LDCM0492  CL97 HCT 116 C136(0.81); C148(0.88); C149(0.99); C244(1.07)  LDD0809  [18]
 LDCM0493  CL98 HCT 116 C136(0.93); C148(1.01); C149(1.11); C244(1.08)  LDD0810  [18]
 LDCM0494  CL99 HCT 116 C136(0.92); C148(0.88); C149(1.10); C244(1.14)  LDD0811  [18]
 LDCM0634  CY-0357 Hep-G2 C430(0.63); C244(0.42)  LDD2228  [27]
 LDCM0495  E2913 HEK-293T C430(1.05); C244(1.16); C187(0.84); C347(1.01)  LDD1698  [43]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C148(5.27); C149(0.89); C244(0.89); C136(0.75)  LDD1702  [41]
 LDCM0031  Epigallocatechin gallate HEK-293T 4.14  LDD0183  [12]
 LDCM0175  Ethacrynic acid HeLa C244(0.77)  LDD2210  [14]
 LDCM0625  F8 Ramos 1.36; C244(0.99); C36(1.30); C430(1.88)  LDD2187  [44]
 LDCM0572  Fragment10 MDA-MB-231 C244(1.47)  LDD1389  [45]
 LDCM0573  Fragment11 MDA-MB-231 C244(1.46)  LDD1391  [45]
 LDCM0574  Fragment12 MDA-MB-231 C244(4.42)  LDD1393  [45]
 LDCM0575  Fragment13 MDA-MB-231 C244(0.91)  LDD1395  [45]
 LDCM0576  Fragment14 MDA-MB-231 C244(1.05)  LDD1397  [45]
 LDCM0577  Fragment15 MDA-MB-231 C244(0.96)  LDD1399  [45]
 LDCM0579  Fragment20 MDA-MB-231 C244(1.24)  LDD1402  [45]
 LDCM0580  Fragment21 MDA-MB-231 C244(0.80)  LDD1404  [45]
 LDCM0581  Fragment22 MDA-MB-231 C244(0.98)  LDD1406  [45]
 LDCM0582  Fragment23 MDA-MB-231 C244(0.86)  LDD1408  [45]
 LDCM0583  Fragment24 Ramos C244(1.08)  LDD1410  [45]
 LDCM0584  Fragment25 MDA-MB-231 C244(0.76)  LDD1411  [45]
 LDCM0585  Fragment26 Ramos C244(0.92)  LDD1412  [45]
 LDCM0578  Fragment27 MDA-MB-231 C244(0.92)  LDD1401  [45]
 LDCM0586  Fragment28 MDA-MB-231 C244(0.85)  LDD1415  [45]
 LDCM0587  Fragment29 MDA-MB-231 C244(1.19)  LDD1417  [45]
 LDCM0588  Fragment30 MDA-MB-231 C244(0.62)  LDD1419  [45]
 LDCM0589  Fragment31 MDA-MB-231 C244(1.15)  LDD1421  [45]
 LDCM0590  Fragment32 MDA-MB-231 C244(4.23)  LDD1423  [45]
 LDCM0468  Fragment33 HCT 116 C136(0.99); C148(0.96); C149(1.08); C244(1.20)  LDD0785  [18]
 LDCM0592  Fragment34 MDA-MB-231 C244(0.72)  LDD1427  [45]
 LDCM0593  Fragment35 Ramos C244(0.80)  LDD1430  [45]
 LDCM0594  Fragment36 MDA-MB-231 C244(1.97)  LDD1431  [45]
 LDCM0595  Fragment37 Ramos C244(0.80)  LDD1432  [45]
 LDCM0596  Fragment38 MDA-MB-231 C244(1.31)  LDD1433  [45]
 LDCM0597  Fragment39 MDA-MB-231 C244(1.21)  LDD1435  [45]
 LDCM0566  Fragment4 MDA-MB-231 C244(1.30)  LDD1378  [45]
 LDCM0598  Fragment40 Ramos C244(0.86)  LDD1437  [45]
 LDCM0599  Fragment41 MDA-MB-231 C244(0.96)  LDD1438  [45]
 LDCM0600  Fragment42 Ramos C244(0.82)  LDD1440  [45]
 LDCM0601  Fragment43 Ramos C244(1.23)  LDD1442  [45]
 LDCM0602  Fragment44 MDA-MB-231 C244(0.80)  LDD1443  [45]
 LDCM0603  Fragment45 MDA-MB-231 C244(1.49)  LDD1444  [45]
 LDCM0604  Fragment46 MDA-MB-231 C244(0.80)  LDD1445  [45]
 LDCM0605  Fragment47 MDA-MB-231 C244(0.77)  LDD1446  [45]
 LDCM0608  Fragment50 MDA-MB-231 C244(1.57)  LDD1449  [45]
 LDCM0427  Fragment51 HCT 116 C136(0.61); C148(0.86); C149(0.78); C244(1.41)  LDD0744  [18]
 LDCM0610  Fragment52 MDA-MB-231 C244(1.50)  LDD1452  [45]
 LDCM0611  Fragment53 MDA-MB-231 C244(0.86)  LDD1454  [45]
 LDCM0612  Fragment54 MDA-MB-231 C244(1.06)  LDD1456  [45]
 LDCM0613  Fragment55 MDA-MB-231 C244(0.89)  LDD1457  [45]
 LDCM0614  Fragment56 MDA-MB-231 C244(0.85)  LDD1458  [45]
 LDCM0568  Fragment6 MDA-MB-231 C244(1.16)  LDD1382  [45]
 LDCM0569  Fragment7 MDA-MB-231 C244(1.32)  LDD1383  [45]
 LDCM0570  Fragment8 MDA-MB-231 C244(0.98)  LDD1385  [45]
 LDCM0571  Fragment9 MDA-MB-231 C244(1.27)  LDD1387  [45]
 LDCM0116  HHS-0101 DM93 Y436(0.92); Y426(0.92)  LDD0264  [16]
 LDCM0117  HHS-0201 DM93 Y436(0.71); Y426(0.79)  LDD0265  [16]
 LDCM0118  HHS-0301 DM93 Y426(0.75); Y436(0.78)  LDD0266  [16]
 LDCM0119  HHS-0401 DM93 Y426(0.75); Y436(0.87)  LDD0267  [16]
 LDCM0120  HHS-0701 DM93 Y436(0.86); Y426(1.03)  LDD0268  [16]
 LDCM0107  IAA HeLa C148(0.00); H21(0.00); H219(0.00); H471(0.00)  LDD0221  [34]
 LDCM0123  JWB131 DM93 Y30(1.02); Y304(0.47); Y426(1.09); Y436(0.63)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y30(0.59); Y304(1.20); Y426(0.83); Y436(0.65)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y30(1.09); Y304(0.39); Y426(0.86); Y436(0.82)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y30(2.99); Y304(1.98); Y426(1.81); Y436(2.39)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y30(1.58); Y304(1.21); Y426(1.49); Y436(1.87)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y30(0.89); Y304(0.64); Y426(0.91); Y436(0.88)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y30(0.71); Y304(0.44); Y426(0.55); Y436(0.58)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y30(0.98); Y304(0.44); Y426(0.94); Y436(0.98)  LDD0292  [15]
 LDCM0179  JZ128 PC-3 C148(0.00); C430(0.00)  LDD0462  [11]
 LDCM0022  KB02 HCT 116 C148(4.35); C149(1.35); C244(1.36)  LDD0080  [18]
 LDCM0023  KB03 HCT 116 C148(4.90); C149(1.23); C244(1.49)  LDD0081  [18]
 LDCM0024  KB05 HCT 116 C148(5.10); C149(1.32); C244(0.83)  LDD0082  [18]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C36(1.21)  LDD2102  [41]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C244(1.30); C430(0.88); C36(0.73)  LDD2121  [41]
 LDCM0109  NEM HeLa H219(0.00); H471(0.00); H303(0.00); H365(0.00)  LDD0223  [34]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C244(0.98); C430(1.06); C36(1.02)  LDD2089  [41]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C430(1.12); C36(1.09)  LDD2090  [41]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C148(1.36); C149(0.97)  LDD2092  [41]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C244(1.13); C36(1.26); C148(1.11); C149(1.21)  LDD2093  [41]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C149(1.57)  LDD2094  [41]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C430(0.39); C148(0.26)  LDD2096  [41]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C36(0.85); C148(0.68); C149(0.99)  LDD2097  [41]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C36(0.50); C148(1.04); C149(1.02)  LDD2098  [41]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C244(0.99); C430(1.13); C36(1.41); C148(1.07)  LDD2099  [41]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C430(0.72)  LDD2100  [41]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C36(0.84); C149(0.92)  LDD2101  [41]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C244(0.77); C36(0.48)  LDD2104  [41]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C244(1.37); C149(2.19)  LDD2105  [41]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C244(0.86); C430(0.54)  LDD2106  [41]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C244(0.96); C430(0.98); C36(1.12); C148(0.77)  LDD2107  [41]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C244(0.67); C430(0.94); C148(0.85); C149(0.61)  LDD2108  [41]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C244(0.98); C430(0.96); C36(0.59); C148(0.73)  LDD2109  [41]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C244(2.70); C430(0.66); C36(0.95)  LDD2110  [41]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C244(1.14); C36(1.43); C149(0.93)  LDD2111  [41]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C244(0.90); C430(0.67); C148(0.69); C149(0.64)  LDD2114  [41]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C36(0.44); C148(0.66); C149(0.94)  LDD2115  [41]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C36(0.22); C148(0.56); C149(0.90)  LDD2116  [41]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C430(1.58); C36(0.19); C148(0.55); C149(0.61)  LDD2118  [41]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C244(1.59); C36(2.47); C149(2.05)  LDD2119  [41]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C36(0.41)  LDD2120  [41]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C430(0.33); C36(0.15); C148(0.45); C149(1.06)  LDD2122  [41]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C244(0.98); C430(1.14); C36(1.02); C148(0.93)  LDD2123  [41]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C430(1.63); C36(0.12); C148(0.45); C149(1.02)  LDD2124  [41]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C244(0.99); C430(1.05); C36(0.92); C148(0.81)  LDD2125  [41]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C36(0.12); C148(0.36)  LDD2126  [41]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C244(1.13); C430(1.08); C36(1.11); C148(0.70)  LDD2127  [41]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C36(0.65); C148(0.31)  LDD2128  [41]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C244(0.99); C36(1.49); C148(1.00); C149(0.93)  LDD2129  [41]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C36(0.45); C148(0.58); C149(0.83)  LDD2133  [41]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C430(0.71); C36(0.40); C149(0.67)  LDD2134  [41]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C244(0.98); C430(1.11); C36(2.11); C148(0.92)  LDD2135  [41]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C430(1.16); C36(1.63); C148(1.18)  LDD2136  [41]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C244(0.97); C430(1.17); C36(1.21); C148(0.73)  LDD2137  [41]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C36(4.35)  LDD1700  [41]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C244(1.01); C36(0.95); C148(0.95); C149(0.94)  LDD2140  [41]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C244(1.06); C430(0.69); C148(0.43); C149(0.58)  LDD2141  [41]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C36(0.43); C148(0.81); C149(0.89)  LDD2143  [41]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C244(1.52); C36(1.83); C148(1.66)  LDD2144  [41]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C36(1.19)  LDD2145  [41]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C244(1.08); C430(1.07); C36(1.07); C148(0.82)  LDD2146  [41]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C36(0.38); C149(0.66)  LDD2148  [41]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C36(0.14); C148(0.56)  LDD2149  [41]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C430(0.73); C36(0.84)  LDD2150  [41]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C36(0.16); C148(0.53); C149(0.50)  LDD2151  [41]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C36(2.37)  LDD2153  [41]
 LDCM0627  NUDT7-COV-1 HEK-293T C244(0.81); C244(0.70); C36(0.62)  LDD2206  [46]
 LDCM0628  OTUB2-COV-1 HEK-293T C244(1.32); C36(1.25); C244(1.10); C430(0.75)  LDD2207  [46]
 LDCM0131  RA190 MM1.R C430(1.54); C149(1.13); C244(1.05)  LDD0304  [47]
 LDCM0021  THZ1 HeLa S3 C244(1.11); C148(1.07); C149(1.05)  LDD0460  [11]
 LDCM0110  W12 Hep-G2 C244(6.33)  LDD0237  [35]
 LDCM0111  W14 Hep-G2 C244(1.96)  LDD0238  [35]
 LDCM0113  W17 Hep-G2 C244(1.72)  LDD0240  [35]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Huntingtin (HTT) Huntingtin family P42858
Sorting nexin-12 (SNX12) Sorting nexin family Q9UMY4
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
T-complex protein 1 subunit alpha (TCP1) TCP-1 chaperonin family P17987
T-complex protein 1 subunit zeta (CCT6A) TCP-1 chaperonin family P40227
Break repair meiotic recombinase recruitment factor 1 (BRME1) . Q0VDD7
Cadherin-related family member 3 (CDHR3) . Q6ZTQ4
Melanoma-associated antigen B6 (MAGEB6) . Q8N7X4

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
10 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
11 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
12 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
13 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
14 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
15 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
16 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
17 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
20 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
21 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
22 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
23 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
24 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
25 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
26 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
27 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
28 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
29 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
30 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
31 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
32 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
33 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
34 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
35 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
36 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
37 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
38 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
39 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
40 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
41 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
42 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
43 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
44 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
45 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
46 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
47 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.