Details of the Target

General Information of Target

Target ID LDTP13580
Target Name Coronin-1C (CORO1C)
Gene Name CORO1C
Gene ID 23603
Synonyms
CRN2; CRNN4; Coronin-1C; Coronin-3; hCRNN4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
Download
Sequence
MFSQQQQQQLQQQQQQLQQLQQQQLQQQQLQQQQLLQLQQLLQQSPPQAPLPMAVSRGLP
PQQPQQPLLNLQGTNSASLLNGSMLQRALLLQQLQGLDQFAMPPATYDTAGLTMPTATLG
NLRGYGMASPGLAAPSLTPPQLATPNLQQFFPQATRQSLLGPPPVGVPMNPSQFNLSGRN
PQKQARTSSSTTPNRKDSSSQTMPVEDKSDPPEGSEEAAEPRMDTPEDQDLPPCPEDIAK
EKRTPAPEPEPCEASELPAKRLRSSEEPTEKEPPGQLQVKAQPQARMTVPKQTQTPDLLP
EALEAQVLPRFQPRVLQVQAQVQSQTQPRIPSTDTQVQPKLQKQAQTQTSPEHLVLQQKQ
VQPQLQQEAEPQKQVQPQVQPQAHSQGPRQVQLQQEAEPLKQVQPQVQPQAHSQPPRQVQ
LQLQKQVQTQTYPQVHTQAQPSVQPQEHPPAQVSVQPPEQTHEQPHTQPQVSLLAPEQTP
VVVHVCGLEMPPDAVEAGGGMEKTLPEPVGTQVSMEEIQNESACGLDVGECENRAREMPG
VWGAGGSLKVTILQSSDSRAFSTVPLTPVPRPSDSVSSTPAATSTPSKQALQFFCYICKA
SCSSQQEFQDHMSEPQHQQRLGEIQHMSQACLLSLLPVPRDVLETEDEEPPPRRWCNTCQ
LYYMGDLIQHRRTQDHKIAKQSLRPFCTVCNRYFKTPRKFVEHVKSQGHKDKAKELKSLE
KEIAGQDEDHFITVDAVGCFEGDEEEEEDDEDEEEIEVEEELCKQVRSRDISREEWKGSE
TYSPNTAYGVDFLVPVMGYICRICHKFYHSNSGAQLSHCKSLGHFENLQKYKAAKNPSPT
TRPVSRRCAINARNALTALFTSSGRPPSQPNTQDKTPSKVTARPSQPPLPRRSTRLKT
Target Bioclass
Other
Family
WD repeat coronin family
Subcellular location
Cell membrane, sarcolemma; Cell membrane
Function
Plays a role in directed cell migration by regulating the activation and subcellular location of RAC1. Increases the presence of activated RAC1 at the leading edge of migrating cells. Required for normal organization of the cytoskeleton, including the actin cytoskeleton, microtubules and the vimentin intermediate filaments. Plays a role in endoplasmic reticulum-associated endosome fission: localizes to endosome membrane tubules and promotes recruitment of TMCC1, leading to recruitment of the endoplasmic reticulum to endosome tubules for fission. Endosome membrane fission of early and late endosomes is essential to separate regions destined for lysosomal degradation from carriers to be recycled to the plasma membrane. Required for normal cell proliferation, cell migration, and normal formation of lamellipodia. Required for normal distribution of mitochondria within cells.; [Isoform 3]: Involved in myogenic differentiation.
Uniprot ID
Q9ULV4
Ensemble ID
ENST00000261401.8
HGNC ID
HGNC:2254

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A3KAW SNV: p.S98N .
HT3 SNV: p.T162A DBIA    Probe Info 
MDAMB157 SNV: p.F10V DBIA    Probe Info 
MEC1 SNV: p.G236E DBIA    Probe Info 
MEWO SNV: p.G114E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 51 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.14  LDD0215  [2]
TH211
 Probe Info  		Y292(11.64); Y273(6.32)  LDD0257  [3]
TH216
 Probe Info  		Y304(20.00)  LDD0259  [3]
YN-1
 Probe Info  		100.00  LDD0444  [4]
YN-4
 Probe Info  		100.00  LDD0445  [4]
ONAyne
 Probe Info  		K464(1.27)  LDD0274  [5]
STPyne
 Probe Info  		K329(10.00); K337(8.33); K391(10.00); K398(3.31)  LDD0277  [5]
BTD
 Probe Info  		C420(4.79); C456(10.13)  LDD1699  [6]
OPA-S-S-alkyne
 Probe Info  		K329(1.19)  LDD3494  [7]
Probe 1
 Probe Info  		Y304(8.03); Y394(62.45)  LDD3495  [8]
DBIA
 Probe Info  		C243(2.12); C92(1.99)  LDD3310  [9]
AHL-Pu-1
 Probe Info  		C283(8.53)  LDD0170  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
HHS-482
 Probe Info  		Y394(0.83)  LDD0285  [12]
HHS-475
 Probe Info  		Y394(0.58); Y304(0.64); Y301(0.79)  LDD0264  [13]
HHS-465
 Probe Info  		Y394(10.00)  LDD2237  [14]
5E-2FA
 Probe Info  		N.A.  LDD2235  [15]
ATP probe
 Probe Info  		N.A.  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C420(0.00); C343(0.00); C23(0.00); C190(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C343(0.00); C190(0.00); C420(0.00); C456(0.00)  LDD0032  [18]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [19]
IPIAA_L
 Probe Info  		C39(0.00); C23(0.00); C283(0.00); C456(0.00)  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C420(0.00); C343(0.00); C456(0.00); C330(0.00)  LDD0037  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
NAIA_4
 Probe Info  		C39(0.00); C343(0.00); C420(0.00); C456(0.00)  LDD2226  [21]
TFBX
 Probe Info  		C420(0.00); C456(0.00)  LDD0027  [20]
WYneC
 Probe Info  		C420(0.00); C190(0.00)  LDD0014  [22]
WYneN
 Probe Info  		C420(0.00); C456(0.00)  LDD0021  [22]
WYneO
 Probe Info  		N.A.  LDD0022  [22]
aHNE
 Probe Info  		N.A.  LDD0001  [22]
1d-yne
 Probe Info  		N.A.  LDD0356  [23]
Compound 10
 Probe Info  		N.A.  LDD2216  [24]
Compound 11
 Probe Info  		N.A.  LDD2213  [24]
ENE
 Probe Info  		C420(0.00); C456(0.00)  LDD0006  [22]
IPM
 Probe Info  		C456(0.00); C420(0.00)  LDD0005  [22]
NPM
 Probe Info  		C420(0.00); C456(0.00)  LDD0016  [22]
PF-06672131
 Probe Info  		N.A.  LDD0017  [25]
PPMS
 Probe Info  		C456(0.00); C190(0.00)  LDD0008  [22]
SF
 Probe Info  		N.A.  LDD0028  [26]
VSF
 Probe Info  		C420(0.00); C456(0.00)  LDD0007  [22]
Phosphinate-6
 Probe Info  		C420(0.00); C456(0.00)  LDD0018  [27]
Ox-W18
 Probe Info  		N.A.  LDD2175  [28]
1c-yne
 Probe Info  		K391(0.00); K428(0.00)  LDD0228  [23]
Acrolein
 Probe Info  		C456(0.00); C39(0.00); H12(0.00); C23(0.00)  LDD0217  [29]
Cinnamaldehyde
 Probe Info  		C456(0.00); C23(0.00)  LDD0220  [29]
Crotonaldehyde
 Probe Info  		C23(0.00); C39(0.00); C190(0.00)  LDD0219  [29]
Methacrolein
 Probe Info  		C23(0.00); C456(0.00); C39(0.00); C190(0.00)  LDD0218  [29]
W1
 Probe Info  		C420(0.00); C456(0.00)  LDD0236  [30]
AOyne
 Probe Info  		15.00  LDD0443  [31]
NAIA_5
 Probe Info  		C23(0.00); C330(0.00); C190(0.00); C456(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		8.06  LDD0475  [32]
FFF probe3
 Probe Info  		5.05  LDD0465  [32]
STS-1
 Probe Info  		N.A.  LDD0136  [33]
STS-2
 Probe Info  		N.A.  LDD0139  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C420(0.67); C330(0.53); C343(0.51)  LDD2142  [6]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C456(0.86); C420(0.85); C330(0.71); C343(0.73)  LDD2112  [6]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C456(0.85); C420(0.71); C330(0.54); C343(0.38)  LDD2095  [6]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C456(0.81); C330(1.00); C343(0.74)  LDD2130  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C456(1.07); C420(0.92); C330(1.04); C343(1.00)  LDD2117  [6]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C456(1.49); C420(1.19); C330(1.50); C343(1.32)  LDD2152  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C456(0.95); C420(0.91); C330(1.09); C343(1.00)  LDD2103  [6]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C456(0.81); C420(0.46); C343(0.43)  LDD2132  [6]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C456(0.95); C420(0.77); C343(0.47)  LDD2131  [6]
 LDCM0025  4SU-RNA DM93 C283(8.53)  LDD0170  [10]
 LDCM0026  4SU-RNA+native RNA DM93 C456(2.65); C420(3.64); C343(2.39)  LDD0171  [10]
 LDCM0214  AC1 HEK-293T C190(0.96); C343(1.05); C420(1.07); C283(0.98)  LDD1507  [34]
 LDCM0215  AC10 HEK-293T C23(1.08); C190(1.07); C343(1.11); C420(0.97)  LDD1508  [34]
 LDCM0226  AC11 HEK-293T C190(1.16); C343(1.05); C420(0.99); C39(1.04)  LDD1509  [34]
 LDCM0237  AC12 HEK-293T C23(1.10); C190(1.10); C343(1.05); C420(0.94)  LDD1510  [34]
 LDCM0259  AC14 HEK-293T C23(1.06); C190(1.09); C343(1.10); C420(0.94)  LDD1512  [34]
 LDCM0270  AC15 HEK-293T C23(1.10); C190(1.13); C343(1.03); C420(1.00)  LDD1513  [34]
 LDCM0276  AC17 HEK-293T C190(1.04); C343(1.17); C420(1.11); C283(1.03)  LDD1515  [34]
 LDCM0277  AC18 HEK-293T C23(1.00); C190(1.08); C343(1.01); C420(1.05)  LDD1516  [34]
 LDCM0278  AC19 HEK-293T C190(1.22); C343(1.06); C420(1.55); C39(0.95)  LDD1517  [34]
 LDCM0279  AC2 HEK-293T C23(1.08); C190(0.99); C343(1.04); C420(0.92)  LDD1518  [34]
 LDCM0280  AC20 HEK-293T C23(1.10); C190(1.10); C343(1.08); C420(1.05)  LDD1519  [34]
 LDCM0281  AC21 HEK-293T C23(1.01); C190(1.08); C343(1.09); C420(0.99)  LDD1520  [34]
 LDCM0282  AC22 HEK-293T C23(1.13); C190(1.07); C343(1.12); C420(1.01)  LDD1521  [34]
 LDCM0283  AC23 HEK-293T C23(1.11); C190(1.08); C343(1.05); C420(1.03)  LDD1522  [34]
 LDCM0284  AC24 HEK-293T C190(1.07); C343(1.00); C420(0.91); C39(0.94)  LDD1523  [34]
 LDCM0285  AC25 HEK-293T C190(1.03); C343(1.13); C420(1.01); C283(1.00)  LDD1524  [34]
 LDCM0286  AC26 HEK-293T C23(0.99); C190(1.08); C343(1.04); C420(1.00)  LDD1525  [34]
 LDCM0287  AC27 HEK-293T C190(1.03); C343(1.05); C420(1.04); C39(0.93)  LDD1526  [34]
 LDCM0288  AC28 HEK-293T C23(1.10); C190(1.10); C343(1.06); C420(1.01)  LDD1527  [34]
 LDCM0289  AC29 HEK-293T C23(1.03); C190(1.09); C343(1.11); C420(0.99)  LDD1528  [34]
 LDCM0290  AC3 HEK-293T C190(1.01); C343(1.01); C420(0.96); C39(0.97)  LDD1529  [34]
 LDCM0291  AC30 HEK-293T C23(0.95); C190(1.09); C343(1.09); C420(0.98)  LDD1530  [34]
 LDCM0292  AC31 HEK-293T C23(1.04); C190(1.06); C343(1.02); C420(1.04)  LDD1531  [34]
 LDCM0293  AC32 HEK-293T C190(1.00); C343(1.01); C420(0.94); C39(1.04)  LDD1532  [34]
 LDCM0294  AC33 HEK-293T C190(0.93); C343(1.10); C420(0.94); C283(1.04)  LDD1533  [34]
 LDCM0295  AC34 HEK-293T C23(0.97); C190(1.01); C343(1.00); C420(0.94)  LDD1534  [34]
 LDCM0296  AC35 HEK-293T C190(0.99); C343(1.07); C420(0.93); C39(0.99)  LDD1535  [34]
 LDCM0297  AC36 HEK-293T C23(1.08); C190(1.06); C343(1.08); C420(0.88)  LDD1536  [34]
 LDCM0298  AC37 HEK-293T C23(1.08); C190(1.04); C343(1.11); C420(0.79)  LDD1537  [34]
 LDCM0299  AC38 HEK-293T C23(1.00); C190(1.13); C343(1.09); C420(0.89)  LDD1538  [34]
 LDCM0300  AC39 HEK-293T C23(1.09); C190(1.05); C343(1.02); C420(0.94)  LDD1539  [34]
 LDCM0301  AC4 HEK-293T C23(1.09); C190(1.06); C343(1.08); C420(0.97)  LDD1540  [34]
 LDCM0302  AC40 HEK-293T C190(1.01); C343(1.01); C420(0.88); C39(0.94)  LDD1541  [34]
 LDCM0303  AC41 HEK-293T C190(0.99); C343(1.12); C420(0.90); C283(0.99)  LDD1542  [34]
 LDCM0304  AC42 HEK-293T C23(1.13); C190(1.12); C343(1.07); C420(0.93)  LDD1543  [34]
 LDCM0305  AC43 HEK-293T C190(1.10); C343(1.13); C420(0.91); C39(1.07)  LDD1544  [34]
 LDCM0306  AC44 HEK-293T C23(1.13); C190(1.05); C343(1.05); C420(0.84)  LDD1545  [34]
 LDCM0307  AC45 HEK-293T C23(1.07); C190(1.03); C343(1.08); C420(0.85)  LDD1546  [34]
 LDCM0308  AC46 HEK-293T C23(0.95); C190(1.12); C343(1.10); C420(0.86)  LDD1547  [34]
 LDCM0309  AC47 HEK-293T C23(1.09); C190(1.16); C343(1.02); C420(0.95)  LDD1548  [34]
 LDCM0310  AC48 HEK-293T C190(1.15); C343(1.01); C420(0.83); C39(0.86)  LDD1549  [34]
 LDCM0311  AC49 HEK-293T C190(1.08); C343(1.11); C420(1.00); C283(1.03)  LDD1550  [34]
 LDCM0312  AC5 HEK-293T C23(1.06); C190(1.03); C343(1.11); C420(0.90)  LDD1551  [34]
 LDCM0313  AC50 HEK-293T C23(1.14); C190(1.12); C343(1.13); C420(0.97)  LDD1552  [34]
 LDCM0314  AC51 HEK-293T C190(1.03); C343(1.08); C420(0.96); C39(1.10)  LDD1553  [34]
 LDCM0315  AC52 HEK-293T C23(1.08); C190(1.11); C343(1.01); C420(0.94)  LDD1554  [34]
 LDCM0316  AC53 HEK-293T C23(1.06); C190(1.07); C343(1.04); C420(0.88)  LDD1555  [34]
 LDCM0317  AC54 HEK-293T C23(1.08); C190(1.07); C343(1.10); C420(0.97)  LDD1556  [34]
 LDCM0318  AC55 HEK-293T C23(1.18); C190(1.13); C343(1.03); C420(0.99)  LDD1557  [34]
 LDCM0319  AC56 HEK-293T C190(1.05); C343(1.02); C420(0.94); C39(0.93)  LDD1558  [34]
 LDCM0320  AC57 HEK-293T C190(0.96); C343(1.06); C420(0.94); C283(1.00)  LDD1559  [34]
 LDCM0321  AC58 HEK-293T C23(1.02); C190(1.00); C343(1.00); C420(0.89)  LDD1560  [34]
 LDCM0322  AC59 HEK-293T C190(1.00); C343(1.05); C420(0.87); C39(0.94)  LDD1561  [34]
 LDCM0323  AC6 HEK-293T C23(1.05); C190(1.05); C343(1.08); C420(1.03)  LDD1562  [34]
 LDCM0324  AC60 HEK-293T C23(1.04); C190(1.06); C343(1.09); C420(0.91)  LDD1563  [34]
 LDCM0325  AC61 HEK-293T C23(1.04); C190(1.02); C343(1.12); C420(0.87)  LDD1564  [34]
 LDCM0326  AC62 HEK-293T C23(1.06); C190(1.02); C343(1.08); C420(0.89)  LDD1565  [34]
 LDCM0327  AC63 HEK-293T C23(1.01); C190(1.02); C343(1.06); C420(0.92)  LDD1566  [34]
 LDCM0328  AC64 HEK-293T C190(1.07); C343(1.02); C420(0.85); C39(0.97)  LDD1567  [34]
 LDCM0334  AC7 HEK-293T C23(1.02); C190(1.07); C343(1.02); C420(0.93)  LDD1568  [34]
 LDCM0345  AC8 HEK-293T C190(0.97); C343(1.04); C420(0.98); C39(1.00)  LDD1569  [34]
 LDCM0545  Acetamide MDA-MB-231 C456(0.60); C420(0.42); C330(0.32); C343(0.72)  LDD2138  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C456(0.66); C420(0.58); C330(0.72); C343(0.79)  LDD2113  [6]
 LDCM0248  AKOS034007472 HEK-293T C23(1.05); C190(1.04); C343(1.12); C420(0.91)  LDD1511  [34]
 LDCM0356  AKOS034007680 HEK-293T C190(1.04); C343(1.11); C420(0.94); C283(1.08)  LDD1570  [34]
 LDCM0275  AKOS034007705 HEK-293T C190(1.05); C343(1.04); C420(0.94); C39(0.96)  LDD1514  [34]
 LDCM0156  Aniline NCI-H1299 11.46  LDD0403  [1]
 LDCM0498  BS-3668 MDA-MB-231 C456(0.50); C420(0.53); C330(0.51); C343(0.78)  LDD2091  [6]
 LDCM0630  CCW28-3 231MFP C420(1.87); C456(1.39)  LDD2214  [35]
 LDCM0108  Chloroacetamide HeLa C39(0.00); C456(0.00); C23(0.00); H12(0.00)  LDD0222  [29]
 LDCM0632  CL-Sc Hep-G2 C420(1.49); C330(0.68); C456(0.67); C420(0.50)  LDD2227  [21]
 LDCM0367  CL1 HEK-293T C23(1.10); C190(0.89); C343(1.10); C420(0.86)  LDD1571  [34]
 LDCM0368  CL10 HEK-293T C23(1.15); C190(0.88); C343(0.89); C420(0.90)  LDD1572  [34]
 LDCM0369  CL100 HEK-293T C23(1.01); C190(0.96); C343(1.04); C420(0.99)  LDD1573  [34]
 LDCM0370  CL101 HEK-293T C23(1.16); C190(1.00); C343(1.07); C420(0.97)  LDD1574  [34]
 LDCM0371  CL102 HEK-293T C23(1.04); C190(1.11); C343(0.99); C420(0.95)  LDD1575  [34]
 LDCM0372  CL103 HEK-293T C23(1.02); C190(1.06); C343(1.17); C420(0.96)  LDD1576  [34]
 LDCM0373  CL104 HEK-293T C23(0.90); C190(1.07); C343(1.07); C420(0.94)  LDD1577  [34]
 LDCM0374  CL105 HEK-293T C23(1.06); C190(0.95); C343(1.07); C420(1.02)  LDD1578  [34]
 LDCM0375  CL106 HEK-293T C23(1.03); C190(1.06); C343(1.00); C420(1.05)  LDD1579  [34]
 LDCM0376  CL107 HEK-293T C23(1.03); C190(1.12); C343(1.17); C420(1.02)  LDD1580  [34]
 LDCM0377  CL108 HEK-293T C23(1.05); C190(1.08); C343(1.18); C420(1.05)  LDD1581  [34]
 LDCM0378  CL109 HEK-293T C23(1.01); C190(0.98); C343(1.08); C420(0.98)  LDD1582  [34]
 LDCM0379  CL11 HEK-293T C23(1.11); C190(0.88); C343(0.80); C420(1.01)  LDD1583  [34]
 LDCM0380  CL110 HEK-293T C23(1.00); C190(1.08); C343(1.04); C420(1.06)  LDD1584  [34]
 LDCM0381  CL111 HEK-293T C23(0.95); C190(1.02); C343(1.08); C420(0.97)  LDD1585  [34]
 LDCM0382  CL112 HEK-293T C23(1.01); C190(1.09); C343(1.05); C420(1.12)  LDD1586  [34]
 LDCM0383  CL113 HEK-293T C23(1.09); C190(0.96); C343(1.10); C420(0.88)  LDD1587  [34]
 LDCM0384  CL114 HEK-293T C23(1.10); C190(1.03); C343(0.98); C420(0.89)  LDD1588  [34]
 LDCM0385  CL115 HEK-293T C23(1.00); C190(1.08); C343(1.08); C420(0.96)  LDD1589  [34]
 LDCM0386  CL116 HEK-293T C23(1.16); C190(1.01); C343(1.06); C420(0.88)  LDD1590  [34]
 LDCM0387  CL117 HEK-293T C23(1.05); C190(1.00); C343(1.13); C420(0.85)  LDD1591  [34]
 LDCM0388  CL118 HEK-293T C23(1.04); C190(1.14); C343(0.95); C420(0.94)  LDD1592  [34]
 LDCM0389  CL119 HEK-293T C23(1.11); C190(1.05); C343(1.15); C420(0.92)  LDD1593  [34]
 LDCM0390  CL12 HEK-293T C190(0.78); C343(0.84); C420(0.93); C39(0.85)  LDD1594  [34]
 LDCM0391  CL120 HEK-293T C23(1.18); C190(1.08); C343(1.03); C420(0.89)  LDD1595  [34]
 LDCM0392  CL121 HEK-293T C23(1.07); C190(1.03); C343(1.06); C420(0.95)  LDD1596  [34]
 LDCM0393  CL122 HEK-293T C23(1.07); C190(1.12); C343(1.06); C420(1.00)  LDD1597  [34]
 LDCM0394  CL123 HEK-293T C23(1.09); C190(1.05); C343(1.06); C420(0.92)  LDD1598  [34]
 LDCM0395  CL124 HEK-293T C23(1.30); C190(1.21); C343(1.11); C420(0.97)  LDD1599  [34]
 LDCM0396  CL125 HEK-293T C23(1.05); C190(0.91); C343(1.11); C420(0.87)  LDD1600  [34]
 LDCM0397  CL126 HEK-293T C23(1.02); C190(0.98); C343(0.98); C420(0.85)  LDD1601  [34]
 LDCM0398  CL127 HEK-293T C23(1.06); C190(0.97); C343(1.22); C420(0.93)  LDD1602  [34]
 LDCM0399  CL128 HEK-293T C23(1.07); C190(1.01); C343(1.01); C420(0.93)  LDD1603  [34]
 LDCM0400  CL13 HEK-293T C23(1.10); C190(0.90); C343(1.16); C420(1.03)  LDD1604  [34]
 LDCM0401  CL14 HEK-293T C23(1.08); C190(1.01); C343(1.01); C420(0.94)  LDD1605  [34]
 LDCM0402  CL15 HEK-293T C23(1.13); C190(0.99); C343(1.20); C420(0.95)  LDD1606  [34]
 LDCM0403  CL16 HEK-293T C23(1.17); C190(0.96); C343(1.02); C420(0.91)  LDD1607  [34]
 LDCM0404  CL17 HEK-293T C190(0.95); C343(1.02); C420(0.93); C283(0.98)  LDD1608  [34]
 LDCM0405  CL18 HEK-293T C23(1.16); C190(1.01); C343(1.08); C420(0.98)  LDD1609  [34]
 LDCM0406  CL19 HEK-293T C190(1.12); C343(1.02); C420(1.02); C39(0.95)  LDD1610  [34]
 LDCM0407  CL2 HEK-293T C23(1.01); C190(0.92); C343(0.99); C420(0.93)  LDD1611  [34]
 LDCM0408  CL20 HEK-293T C23(1.20); C190(0.96); C343(0.88); C420(0.94)  LDD1612  [34]
 LDCM0409  CL21 HEK-293T C23(1.13); C190(0.97); C343(0.95); C420(0.88)  LDD1613  [34]
 LDCM0410  CL22 HEK-293T C23(1.09); C190(0.98); C343(0.87); C420(0.92)  LDD1614  [34]
 LDCM0411  CL23 HEK-293T C23(1.18); C190(0.95); C343(0.76); C420(1.00)  LDD1615  [34]
 LDCM0412  CL24 HEK-293T C190(0.85); C343(0.84); C420(0.95); C39(0.87)  LDD1616  [34]
 LDCM0413  CL25 HEK-293T C23(0.96); C190(1.00); C343(1.02); C420(0.91)  LDD1617  [34]
 LDCM0414  CL26 HEK-293T C23(1.06); C190(0.99); C343(1.03); C420(1.03)  LDD1618  [34]
 LDCM0415  CL27 HEK-293T C23(0.97); C190(1.02); C343(1.16); C420(0.99)  LDD1619  [34]
 LDCM0416  CL28 HEK-293T C23(0.89); C190(1.14); C343(1.08); C420(1.01)  LDD1620  [34]
 LDCM0417  CL29 HEK-293T C190(0.96); C343(1.14); C420(1.04); C283(1.00)  LDD1621  [34]
 LDCM0418  CL3 HEK-293T C23(1.04); C190(1.00); C343(1.15); C420(0.92)  LDD1622  [34]
 LDCM0419  CL30 HEK-293T C23(1.11); C190(1.03); C343(1.05); C420(1.04)  LDD1623  [34]
 LDCM0420  CL31 HEK-293T C190(1.17); C343(0.99); C420(1.21); C39(1.00)  LDD1624  [34]
 LDCM0421  CL32 HEK-293T C23(1.25); C190(1.06); C343(0.94); C420(1.08)  LDD1625  [34]
 LDCM0422  CL33 HEK-293T C23(1.33); C190(0.95); C343(0.91); C420(0.95)  LDD1626  [34]
 LDCM0423  CL34 HEK-293T C23(1.03); C190(1.01); C343(0.86); C420(1.03)  LDD1627  [34]
 LDCM0424  CL35 HEK-293T C23(1.15); C190(0.91); C343(0.78); C420(1.20)  LDD1628  [34]
 LDCM0425  CL36 HEK-293T C190(0.91); C343(0.82); C420(1.01); C39(0.94)  LDD1629  [34]
 LDCM0426  CL37 HEK-293T C23(1.04); C190(0.88); C343(1.08); C420(0.91)  LDD1630  [34]
 LDCM0428  CL39 HEK-293T C23(1.03); C190(1.04); C343(1.10); C420(1.00)  LDD1632  [34]
 LDCM0429  CL4 HEK-293T C23(1.10); C190(0.97); C343(1.06); C420(0.92)  LDD1633  [34]
 LDCM0430  CL40 HEK-293T C23(1.10); C190(1.11); C343(1.08); C420(0.96)  LDD1634  [34]
 LDCM0431  CL41 HEK-293T C190(0.94); C343(1.17); C420(1.01); C283(0.88)  LDD1635  [34]
 LDCM0432  CL42 HEK-293T C23(1.07); C190(0.99); C343(1.08); C420(1.01)  LDD1636  [34]
 LDCM0433  CL43 HEK-293T C190(1.01); C343(0.99); C420(1.02); C39(0.97)  LDD1637  [34]
 LDCM0434  CL44 HEK-293T C23(1.26); C190(0.96); C343(0.99); C420(1.02)  LDD1638  [34]
 LDCM0435  CL45 HEK-293T C23(1.14); C190(0.99); C343(0.92); C420(1.02)  LDD1639  [34]
 LDCM0436  CL46 HEK-293T C23(1.10); C190(1.00); C343(0.86); C420(1.01)  LDD1640  [34]
 LDCM0437  CL47 HEK-293T C23(1.17); C190(0.93); C343(0.81); C420(1.12)  LDD1641  [34]
 LDCM0438  CL48 HEK-293T C190(0.95); C343(0.82); C420(0.99); C39(0.89)  LDD1642  [34]
 LDCM0439  CL49 HEK-293T C23(1.03); C190(0.95); C343(1.16); C420(0.85)  LDD1643  [34]
 LDCM0440  CL5 HEK-293T C190(0.90); C343(1.09); C420(1.01); C283(1.04)  LDD1644  [34]
 LDCM0441  CL50 HEK-293T C23(1.04); C190(0.91); C343(0.95); C420(0.97)  LDD1645  [34]
 LDCM0443  CL52 HEK-293T C23(1.62); C190(0.93); C343(1.12); C420(0.92)  LDD1646  [34]
 LDCM0444  CL53 HEK-293T C190(0.98); C343(1.04); C420(0.91); C283(1.03)  LDD1647  [34]
 LDCM0445  CL54 HEK-293T C23(1.11); C190(1.10); C343(1.09); C420(0.98)  LDD1648  [34]
 LDCM0446  CL55 HEK-293T C190(0.91); C343(0.99); C420(1.03); C39(0.90)  LDD1649  [34]
 LDCM0447  CL56 HEK-293T C23(1.15); C190(0.98); C343(0.99); C420(0.94)  LDD1650  [34]
 LDCM0448  CL57 HEK-293T C23(1.16); C190(0.97); C343(0.88); C420(0.95)  LDD1651  [34]
 LDCM0449  CL58 HEK-293T C23(1.21); C190(1.02); C343(0.85); C420(0.93)  LDD1652  [34]
 LDCM0450  CL59 HEK-293T C23(1.23); C190(0.95); C343(0.76); C420(1.01)  LDD1653  [34]
 LDCM0451  CL6 HEK-293T C23(1.08); C190(0.91); C343(1.07); C420(0.90)  LDD1654  [34]
 LDCM0452  CL60 HEK-293T C190(0.89); C343(0.82); C420(0.87); C39(0.86)  LDD1655  [34]
 LDCM0453  CL61 HEK-293T C23(1.04); C190(0.98); C343(1.11); C420(0.84)  LDD1656  [34]
 LDCM0454  CL62 HEK-293T C23(0.96); C190(1.02); C343(1.00); C420(0.93)  LDD1657  [34]
 LDCM0455  CL63 HEK-293T C23(1.05); C190(1.05); C343(1.14); C420(0.95)  LDD1658  [34]
 LDCM0456  CL64 HEK-293T C23(0.91); C190(1.10); C343(1.03); C420(0.88)  LDD1659  [34]
 LDCM0457  CL65 HEK-293T C190(0.94); C343(1.07); C420(0.96); C283(1.11)  LDD1660  [34]
 LDCM0458  CL66 HEK-293T C23(1.02); C190(1.02); C343(0.99); C420(0.92)  LDD1661  [34]
 LDCM0459  CL67 HEK-293T C190(1.05); C343(0.98); C420(0.95); C39(1.04)  LDD1662  [34]
 LDCM0460  CL68 HEK-293T C23(1.14); C190(0.95); C343(0.93); C420(0.93)  LDD1663  [34]
 LDCM0461  CL69 HEK-293T C23(1.13); C190(0.99); C343(0.89); C420(0.84)  LDD1664  [34]
 LDCM0462  CL7 HEK-293T C190(0.87); C343(1.02); C420(1.02); C39(1.02)  LDD1665  [34]
 LDCM0463  CL70 HEK-293T C23(1.05); C190(0.98); C343(0.87); C420(0.93)  LDD1666  [34]
 LDCM0464  CL71 HEK-293T C23(1.18); C190(0.97); C343(0.74); C420(1.02)  LDD1667  [34]
 LDCM0465  CL72 HEK-293T C190(0.93); C343(0.84); C420(0.87); C39(0.86)  LDD1668  [34]
 LDCM0466  CL73 HEK-293T C23(1.07); C190(0.94); C343(1.22); C420(0.90)  LDD1669  [34]
 LDCM0467  CL74 HEK-293T C23(0.97); C190(0.91); C343(1.00); C420(0.96)  LDD1670  [34]
 LDCM0469  CL76 HEK-293T C23(1.22); C190(1.01); C343(1.08); C420(0.95)  LDD1672  [34]
 LDCM0470  CL77 HEK-293T C190(0.96); C343(1.09); C420(0.97); C283(0.98)  LDD1673  [34]
 LDCM0471  CL78 HEK-293T C23(1.02); C190(1.02); C343(1.13); C420(1.05)  LDD1674  [34]
 LDCM0472  CL79 HEK-293T C190(1.08); C343(1.01); C420(1.03); C39(1.01)  LDD1675  [34]
 LDCM0473  CL8 HEK-293T C23(1.04); C190(0.86); C343(0.87); C420(0.87)  LDD1676  [34]
 LDCM0474  CL80 HEK-293T C23(1.21); C190(0.97); C343(0.94); C420(0.95)  LDD1677  [34]
 LDCM0475  CL81 HEK-293T C23(1.13); C190(1.02); C343(0.97); C420(0.97)  LDD1678  [34]
 LDCM0476  CL82 HEK-293T C23(1.12); C190(1.03); C343(0.94); C420(0.93)  LDD1679  [34]
 LDCM0477  CL83 HEK-293T C23(1.14); C190(0.98); C343(0.82); C420(1.02)  LDD1680  [34]
 LDCM0478  CL84 HEK-293T C190(0.85); C343(0.86); C420(0.96); C39(1.02)  LDD1681  [34]
 LDCM0479  CL85 HEK-293T C23(0.99); C190(0.86); C343(1.16); C420(0.82)  LDD1682  [34]
 LDCM0480  CL86 HEK-293T C23(0.98); C190(0.87); C343(0.94); C420(0.76)  LDD1683  [34]
 LDCM0481  CL87 HEK-293T C23(1.09); C190(0.92); C343(1.19); C420(0.90)  LDD1684  [34]
 LDCM0482  CL88 HEK-293T C23(1.15); C190(0.93); C343(1.07); C420(0.88)  LDD1685  [34]
 LDCM0483  CL89 HEK-293T C190(0.89); C343(1.08); C420(0.90); C283(0.99)  LDD1686  [34]
 LDCM0484  CL9 HEK-293T C23(1.12); C190(0.93); C343(0.98); C420(0.90)  LDD1687  [34]
 LDCM0485  CL90 HEK-293T C23(1.08); C190(1.10); C343(1.19); C420(0.81)  LDD1688  [34]
 LDCM0486  CL91 HEK-293T C190(0.96); C343(1.02); C420(0.87); C39(1.00)  LDD1689  [34]
 LDCM0487  CL92 HEK-293T C23(1.09); C190(0.98); C343(0.93); C420(0.86)  LDD1690  [34]
 LDCM0488  CL93 HEK-293T C23(1.15); C190(0.94); C343(0.94); C420(0.82)  LDD1691  [34]
 LDCM0489  CL94 HEK-293T C23(1.03); C190(0.93); C343(0.90); C420(0.93)  LDD1692  [34]
 LDCM0490  CL95 HEK-293T C23(1.06); C190(0.98); C343(0.89); C420(0.98)  LDD1693  [34]
 LDCM0491  CL96 HEK-293T C190(0.81); C343(0.83); C420(0.80); C39(1.01)  LDD1694  [34]
 LDCM0492  CL97 HEK-293T C23(1.05); C190(0.87); C343(1.05); C420(0.95)  LDD1695  [34]
 LDCM0493  CL98 HEK-293T C23(0.95); C190(0.92); C343(0.89); C420(0.96)  LDD1696  [34]
 LDCM0494  CL99 HEK-293T C23(0.97); C190(1.01); C343(1.05); C420(0.98)  LDD1697  [34]
 LDCM0634  CY-0357 Hep-G2 C456(1.03); C420(0.74); C420(0.72)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C23(1.02); C190(0.97); C343(1.09); C420(0.98)  LDD1698  [34]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C343(1.50); C420(1.26); C456(1.01)  LDD1702  [6]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0625  F8 Ramos C420(1.38); C456(1.42); C190(0.80); C39(0.56)  LDD2187  [36]
 LDCM0572  Fragment10 MDA-MB-231 C420(2.12); C456(1.25)  LDD1389  [37]
 LDCM0573  Fragment11 MDA-MB-231 C420(2.99)  LDD1391  [37]
 LDCM0574  Fragment12 MDA-MB-231 C420(1.31); C456(1.03)  LDD1393  [37]
 LDCM0575  Fragment13 MDA-MB-231 C420(1.22); C456(0.89)  LDD1395  [37]
 LDCM0576  Fragment14 MDA-MB-231 C420(0.69); C456(1.30)  LDD1397  [37]
 LDCM0577  Fragment15 Ramos C420(1.44); C456(1.02)  LDD1400  [37]
 LDCM0579  Fragment20 MDA-MB-231 C420(2.67); C456(1.28)  LDD1402  [37]
 LDCM0580  Fragment21 MDA-MB-231 C420(1.06); C456(0.96)  LDD1404  [37]
 LDCM0581  Fragment22 MDA-MB-231 C420(1.43); C456(1.15)  LDD1406  [37]
 LDCM0582  Fragment23 MDA-MB-231 C420(1.16); C456(3.16)  LDD1408  [37]
 LDCM0583  Fragment24 Ramos C420(1.28)  LDD1410  [37]
 LDCM0584  Fragment25 MDA-MB-231 C420(0.87); C456(0.88)  LDD1411  [37]
 LDCM0578  Fragment27 MDA-MB-231 C420(0.88); C456(1.00)  LDD1401  [37]
 LDCM0586  Fragment28 MDA-MB-231 C420(0.96); C456(0.79)  LDD1415  [37]
 LDCM0587  Fragment29 MDA-MB-231 C420(1.39); C456(1.09)  LDD1417  [37]
 LDCM0588  Fragment30 MDA-MB-231 C420(0.90); C456(0.95)  LDD1419  [37]
 LDCM0589  Fragment31 MDA-MB-231 C420(1.58); C456(1.22)  LDD1421  [37]
 LDCM0590  Fragment32 MDA-MB-231 C420(2.25); C456(1.02)  LDD1423  [37]
 LDCM0468  Fragment33 MDA-MB-231 C420(0.86); C456(0.80)  LDD1425  [37]
 LDCM0592  Fragment34 MDA-MB-231 C420(0.78)  LDD1427  [37]
 LDCM0593  Fragment35 MDA-MB-231 C420(0.81); C456(0.90)  LDD1429  [37]
 LDCM0594  Fragment36 MDA-MB-231 C420(1.75)  LDD1431  [37]
 LDCM0595  Fragment37 Ramos C420(0.91)  LDD1432  [37]
 LDCM0596  Fragment38 MDA-MB-231 C420(1.04); C456(1.07)  LDD1433  [37]
 LDCM0597  Fragment39 MDA-MB-231 C420(1.33)  LDD1435  [37]
 LDCM0566  Fragment4 MDA-MB-231 C420(1.58); C456(1.17)  LDD1378  [37]
 LDCM0598  Fragment40 MDA-MB-231 C420(0.82); C456(0.75)  LDD1436  [37]
 LDCM0599  Fragment41 MDA-MB-231 C420(1.25); C456(1.75)  LDD1438  [37]
 LDCM0601  Fragment43 MDA-MB-231 C420(1.75); C456(0.88)  LDD1441  [37]
 LDCM0602  Fragment44 MDA-MB-231 C420(0.81)  LDD1443  [37]
 LDCM0603  Fragment45 MDA-MB-231 C420(4.60); C456(1.46)  LDD1444  [37]
 LDCM0604  Fragment46 MDA-MB-231 C420(1.01); C456(0.89)  LDD1445  [37]
 LDCM0605  Fragment47 MDA-MB-231 C420(1.38); C456(1.54)  LDD1446  [37]
 LDCM0606  Fragment48 MDA-MB-231 C420(1.18); C456(1.29)  LDD1447  [37]
 LDCM0607  Fragment49 MDA-MB-231 C420(3.13); C456(1.42)  LDD1448  [37]
 LDCM0608  Fragment50 MDA-MB-231 C420(1.41); C456(1.25)  LDD1449  [37]
 LDCM0427  Fragment51 MDA-MB-231 C420(0.85); C456(0.59)  LDD1450  [37]
 LDCM0610  Fragment52 MDA-MB-231 C420(1.06); C456(0.96)  LDD1452  [37]
 LDCM0611  Fragment53 MDA-MB-231 C420(0.90); C456(0.78)  LDD1454  [37]
 LDCM0612  Fragment54 MDA-MB-231 C420(1.17)  LDD1456  [37]
 LDCM0613  Fragment55 MDA-MB-231 C420(0.93); C456(0.96)  LDD1457  [37]
 LDCM0614  Fragment56 MDA-MB-231 C420(1.01); C456(0.76)  LDD1458  [37]
 LDCM0568  Fragment6 MDA-MB-231 C420(1.13)  LDD1382  [37]
 LDCM0569  Fragment7 MDA-MB-231 C420(1.73)  LDD1383  [37]
 LDCM0570  Fragment8 MDA-MB-231 C420(2.35); C456(1.02)  LDD1385  [37]
 LDCM0571  Fragment9 MDA-MB-231 C420(1.26); C456(0.80)  LDD1387  [37]
 LDCM0116  HHS-0101 DM93 Y394(0.58); Y304(0.64); Y301(0.79)  LDD0264  [13]
 LDCM0117  HHS-0201 DM93 Y304(0.44); Y394(0.60); Y301(3.84)  LDD0265  [13]
 LDCM0118  HHS-0301 DM93 Y394(0.24); Y304(0.64); Y301(10.04)  LDD0266  [13]
 LDCM0119  HHS-0401 DM93 Y394(0.40); Y304(0.77); Y301(3.98)  LDD0267  [13]
 LDCM0120  HHS-0701 DM93 Y301(0.64); Y394(1.60); Y304(10.18)  LDD0268  [13]
 LDCM0107  IAA HeLa C39(0.00); H12(0.00); C23(0.00)  LDD0221  [29]
 LDCM0123  JWB131 DM93 Y394(0.83)  LDD0285  [12]
 LDCM0124  JWB142 DM93 Y394(0.65)  LDD0286  [12]
 LDCM0125  JWB146 DM93 Y394(0.84)  LDD0287  [12]
 LDCM0126  JWB150 DM93 Y394(3.07)  LDD0288  [12]
 LDCM0127  JWB152 DM93 Y394(2.13)  LDD0289  [12]
 LDCM0128  JWB198 DM93 Y394(1.20)  LDD0290  [12]
 LDCM0129  JWB202 DM93 Y394(0.61)  LDD0291  [12]
 LDCM0130  JWB211 DM93 Y394(0.77)  LDD0292  [12]
 LDCM0022  KB02 MDA-MB-231 C420(4.23); C456(1.25)  LDD1374  [37]
 LDCM0023  KB03 MDA-MB-231 C420(1.83); C456(1.58)  LDD1376  [37]
 LDCM0024  KB05 COLO792 C243(2.12); C92(1.99)  LDD3310  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C456(1.04); C420(0.83); C330(1.25); C343(1.34)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C456(0.52); C420(0.57); C330(0.52); C343(0.89)  LDD2121  [6]
 LDCM0109  NEM HeLa N.A.  LDD0223  [29]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C456(0.57); C420(0.62); C330(0.49); C343(0.99)  LDD2089  [6]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C420(1.19); C330(1.38); C190(1.12)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C456(0.91); C420(0.83); C330(0.99); C343(1.13)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C456(1.42); C420(1.14); C330(1.03); C343(1.17)  LDD2093  [6]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C456(0.97); C420(0.87); C330(1.31); C343(1.96)  LDD2094  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C456(0.48); C330(0.39); C343(0.25); C190(1.52)  LDD2096  [6]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C456(0.87); C420(0.77); C330(0.79); C343(0.78)  LDD2097  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C456(0.78); C420(1.11); C330(0.81); C343(1.10)  LDD2098  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C456(0.86); C420(0.74); C330(0.89); C343(1.01)  LDD2099  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C456(0.94); C420(0.89); C330(0.57); C343(0.41)  LDD2100  [6]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C456(0.43); C420(0.72); C330(0.64); C343(0.76)  LDD2101  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C456(0.91); C420(0.90); C330(0.55); C343(0.48)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C420(1.35); C330(1.60)  LDD2105  [6]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C420(0.83); C330(0.54)  LDD2106  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C456(1.03); C420(0.70); C330(0.97); C343(0.94)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C420(0.90); C330(0.72); C343(0.66)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C456(0.69); C420(0.91); C330(0.65); C343(0.61)  LDD2109  [6]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C456(1.68); C420(1.79); C330(0.93); C343(0.44)  LDD2110  [6]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C456(1.20); C420(0.88); C343(0.94); C190(0.80)  LDD2111  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C456(0.89); C420(0.61); C330(0.82); C343(0.52)  LDD2114  [6]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C456(0.33); C420(0.50); C330(0.64); C343(0.50)  LDD2115  [6]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C456(2.12); C420(1.85); C330(0.62); C343(0.48)  LDD2116  [6]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C456(0.51); C420(2.14); C330(0.79); C343(0.53)  LDD2118  [6]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C456(2.74); C420(2.79); C330(2.79); C343(1.97)  LDD2119  [6]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C456(0.91); C420(0.88); C330(0.83); C343(0.67)  LDD2120  [6]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C456(0.51); C420(2.04); C330(0.54); C343(0.33)  LDD2122  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C456(0.71); C420(0.88); C330(0.91); C343(0.84)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C456(0.38); C420(1.97); C343(0.31); C190(0.28)  LDD2124  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C456(0.97); C420(0.76); C330(0.81); C39(1.07)  LDD2125  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C456(0.55); C420(2.31); C330(0.60); C343(0.36)  LDD2126  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C456(0.97); C420(1.01); C330(1.08); C343(1.09)  LDD2127  [6]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C456(0.95); C420(1.19); C330(0.95); C343(0.60)  LDD2128  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C456(0.91); C420(0.99); C330(1.10); C343(1.31)  LDD2129  [6]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C456(0.53); C420(0.57); C330(0.70); C343(0.58)  LDD2133  [6]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C420(0.45); C330(0.66); C343(0.55); C39(0.52)  LDD2134  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C456(0.68); C420(1.04); C330(1.24); C343(1.61)  LDD2135  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C456(0.92); C420(1.12); C330(1.06); C343(1.06)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C456(0.67); C420(0.87); C330(1.00); C343(0.90)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C330(1.79); C343(1.75); C190(1.60); C456(1.16)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C456(0.89); C420(0.68); C330(0.66); C343(0.79)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C420(0.73); C330(0.71); C343(0.57)  LDD2141  [6]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C420(1.00); C330(1.05); C343(0.64)  LDD2143  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C456(2.90); C420(2.73); C330(3.35); C343(2.13)  LDD2144  [6]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C456(6.54); C420(4.72); C330(1.09); C343(0.33)  LDD2145  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C456(0.96); C420(0.80); C330(0.87); C343(0.95)  LDD2146  [6]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C456(1.85); C420(2.80); C330(3.65); C343(1.06)  LDD2147  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C456(0.52); C420(0.55); C330(0.53); C343(0.37)  LDD2148  [6]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C420(2.96); C330(0.59); C343(0.56); C190(0.34)  LDD2149  [6]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C456(0.57); C420(0.40); C330(0.41); C343(0.65)  LDD2150  [6]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C456(0.60); C330(0.52); C343(0.41)  LDD2151  [6]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C420(2.11); C330(1.64); C343(3.08); C190(1.37)  LDD2153  [6]
 LDCM0627  NUDT7-COV-1 HEK-293T C456(0.51)  LDD2206  [38]
 LDCM0628  OTUB2-COV-1 HEK-293T C456(0.07)  LDD2207  [38]
 LDCM0131  RA190 MM1.R C23(1.42); C420(1.29); C39(1.20); C456(1.17)  LDD0304  [39]
 LDCM0170  Structure8 Ramos 5.71  LDD0433  [40]
 LDCM0112  W16 Hep-G2 C420(0.54)  LDD0239  [30]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Coronin-1B (CORO1B) WD repeat coronin family Q9BR76

References

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Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
5 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
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Mass spectrometry data entry: PXD047840
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
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15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
17 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
18 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
19 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
21 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
25 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD039931
27 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
28 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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