Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment33  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cell lysate (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 68 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 17.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 4.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 4.3
 LDTP02502  Thioredoxin (TXN) C32 4.2
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 3.7
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 3.4
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 3.3
 LDTP06211  Caspase-8 (CASP8) C360 3.1
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 2.3
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.0
 LDTP02672  Elongation factor 2 (EEF2) C136 1.9
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 1.9
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.8
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 1.8
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.6
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 1.5
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 1.4
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.4
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.3
 LDTP00482  Peripheral plasma membrane protein CASK (CASK) C914 1.3
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.3
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.3
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 1.3
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.2
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 1.2
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.2
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.2
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.2
 LDTP13147  Cathepsin Z (CTSZ) C173 1.1
 LDTP02576  Pyruvate carboxylase, mitochondrial (PC) C622 1.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.1
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 1.1
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.1
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.1
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C377 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.1
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 1.1
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.1
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.0
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.0
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.0
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.0
 LDTP02223  Cathepsin B (CTSB) C319 1.0
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.0
 LDTP02672  Elongation factor 2 (EEF2) C41 1.0
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.9
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 0.9
 LDTP03496  Protein PML (PML) C389 0.9
 LDTP04689  Adenosine kinase (ADK) C353 0.9
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 0.9
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.9
 LDTP03400  Deoxycytidine kinase (DCK) C9 0.8
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.8
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.7
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 5.3
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 3.5
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 1.9
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.3
 LDTP04801  Gasdermin-D (GSDMD) C268 1.2
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.2
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.9
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.8
 LDTP00501  Exportin-1 (XPO1) C34 0.8
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.5
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.9
Other
Click to Show/Hide to Show 54 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02692  Plastin-3 (PLS3) C33 2.4
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 2.1
 LDTP06681  Inverted formin-2 (INF2) C971 2.0
 LDTP04092  Crk-like protein (CRKL) C249 1.7
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.6
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.6
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.5
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.3
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.3
 LDTP10864  Calponin-2 (CNN2) C164 1.2
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.2
 LDTP12412  Reticulon-4 (RTN4) C1101 1.2
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.2
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.1
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.1
 LDTP10864  Calponin-2 (CNN2) C215 1.1
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 1.1
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.1
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.1
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.1
 LDTP06542  Cysteine and glycine-rich protein 2 (CSRP2) C33 1.1
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.0
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.0
 LDTP02205  Tubulin beta chain (TUBB) C239 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.0
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.0
 LDTP12638  Protein lin-7 homolog C (LIN7C) C47 1.0
 LDTP11235  Protein PAXX (PAXX) C180 1.0
 LDTP18494  Tropomodulin-3 (TMOD3) C132 1.0
 LDTP01532  ZW10 interactor (ZWINT) C54 1.0
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 1.0
 LDTP03841  Hippocalcin-like protein 1 (HPCAL1) C185 1.0
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.0
 LDTP02205  Tubulin beta chain (TUBB) C354 1.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 0.9
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 0.9
 LDTP05597  Neuroblast differentiation-associated protein AHNAK (AHNAK) C108 0.9
 LDTP03620  Protein S100-A11 (S100A11) C91 0.9
 LDTP13580  Coronin-1C (CORO1C) C420 0.9
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.9
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.9
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 0.9
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.8
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.8
 LDTP13580  Coronin-1C (CORO1C) C456 0.8
 LDTP02631  Alpha-actinin-1 (ACTN1) C370 0.8
 LDTP03244  Cofilin-1 (CFL1) C80 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.8
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 0.7

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.