Details of the Target

General Information of Target

Target ID LDTP06681
Target Name Inverted formin-2 (INF2)
Gene Name INF2
Gene ID 64423
Synonyms
C14orf151; C14orf173; Inverted formin-2; HBEBP2-binding protein C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVKEGAQRKWAALKEKLGPQDSDPTEANLESADPELCIRLLQMPSVVNYSGLRKRLEGS
DGGWMVQFLEQSGLDLLLEALARLSGRGVARISDALLQLTCVSCVRAVMNSRQGIEYILS
NQGYVRQLSQALDTSNVMVKKQVFELLAALCIYSPEGHVLTLDALDHYKTVCSQQYRFSI
VMNELSGSDNVPYVVTLLSVINAVILGPEDLRARTQLRNEFIGLQLLDVLARLRDLEDAD
LLIQLEAFEEAKAEDEEELLRVSGGVDMSSHQEVFASLFHKVSCSPVSAQLLSVLQGLLH
LEPTLRSSQLLWEALESLVNRAVLLASDAQECTLEEVVERLLSVKGRPRPSPLVKAHKSV
QANLDQSQRGSSPQNTTTPKPSVEGQQPAAAAACEPVDHAQSESILKVSQPRALEQQAST
PPPPPPPPLLPGSSAEPPPPPPPPPLPSVGAKALPTAPPPPPLPGLGAMAPPAPPLPPPL
PGSCEFLPPPPPPLPGLGCPPPPPPLLPGMGWGPPPPPPPLLPCTCSPPVAGGMEEVIVA
QVDHGLGSAWVPSHRRVNPPTLRMKKLNWQKLPSNVAREHNSMWASLSSPDAEAVEPDFS
SIERLFSFPAAKPKEPTMVAPRARKEPKEITFLDAKKSLNLNIFLKQFKCSNEEVAAMIR
AGDTTKFDVEVLKQLLKLLPEKHEIENLRAFTEERAKLASADHFYLLLLAIPCYQLRIEC
MLLCEGAAAVLDMVRPKAQLVLAACESLLTSRQLPIFCQLILRIGNFLNYGSHTGDADGF
KISTLLKLTETKSQQNRVTLLHHVLEEAEKSHPDLLQLPRDLEQPSQAAGINLEIIRSEA
SSNLKKLLETERKVSASVAEVQEQYTERLQASISAFRALDELFEAIEQKQRELADYLCED
AQQLSLEDTFSTMKAFRDLFLRALKENKDRKEQAAKAERRKQQLAEEEARRPRGEDGKPV
RKGPGKQEEVCVIDALLADIRKGFQLRKTARGRGDTDGGSKAASMDPPRATEPVATSNPA
GDPVGSTRCPASEPGLDATTASESRGWDLVDAVTPGPQPTLEQLEEGGPRPLERRSSWYV
DASDVLTTEDPQCPQPLEGAWPVTLGDAQALKPLKFSSNQPPAAGSSRQDAKDPTSLLGV
LQAEADSTSEGLEDAVHSRGARPPAAGPGGDEDEDEEDTAPESALDTSLDKSFSEDAVTD
SSGSGTLPRARGRASKGTGKRRKKRPSRSQEEVPPDSDDNKTKKLCVIQ
Target Bioclass
Other
Family
Formin homology family
Subcellular location
Cytoplasm, perinuclear region
Function Severs actin filaments and accelerates their polymerization and depolymerization.
Uniprot ID
Q27J81
Ensemble ID
ENST00000330634.11
HGNC ID
HGNC:23791

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.G1170E DBIA    Probe Info 
AN3CA Deletion: p.V530WfsTer28
SNV: p.R1221Ter		 .
CHL1 SNV: p.G1170E DBIA    Probe Info 
DU145 Insertion: p.A473SfsTer13 DBIA    Probe Info 
EFO21 SNV: p.M618T DBIA    Probe Info 
HCT116 Deletion: p.G1139AfsTer60 DBIA    Probe Info 
HCT15 SNV: p.P286L; p.P303S; p.A1180T DBIA    Probe Info 
Ishikawa (Heraklio) 02 ER SNV: p.Q142R DBIA    Probe Info 
KPL1 SNV: p.D1239A DBIA    Probe Info 
MFE319 Deletion: p.V530WfsTer28; p.R622GfsTer18 DBIA    Probe Info 
OVCAR8 SNV: p.R214H DBIA    Probe Info 
PC9 SNV: p.P1122H .
RD SNV: p.H300Q DBIA    Probe Info 
RL952 SNV: p.S85L DBIA    Probe Info 
TOV21G SNV: p.Q374K DBIA    Probe Info 
U937 SNV: p.Q903K DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
CY4
 Probe Info  		100.00  LDD0244  [2]
ONAyne
 Probe Info  		K345(0.87)  LDD0274  [3]
STPyne
 Probe Info  		K10(7.40); K345(8.86); K358(5.60); K571(10.00)  LDD0277  [3]
Probe 1
 Probe Info  		Y865(12.44)  LDD3495  [4]
JZ128-DTB
 Probe Info  		C38(0.00); C332(0.00)  LDD0462  [5]
THZ1-DTB
 Probe Info  		C38(1.05)  LDD0460  [5]
BTD
 Probe Info  		C172(1.45)  LDD1700  [6]
DA-P3
 Probe Info  		10.80  LDD0180  [7]
AHL-Pu-1
 Probe Info  		C394(2.03)  LDD0168  [8]
DBIA
 Probe Info  		C1029(1.13); C38(0.99); C104(0.92); C758(0.88)  LDD0078  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C971(0.00); C172(0.00); C284(0.00); C650(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C650(0.00); C713(0.00); C758(0.00); C172(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C720(0.00); C724(0.00); C971(0.00); C172(0.00)  LDD0037  [10]
IPM
 Probe Info  		C1029(0.00); C332(0.00)  LDD0025  [11]
JW-RF-010
 Probe Info  		C332(0.00); C38(0.00)  LDD0026  [11]
NAIA_4
 Probe Info  		C38(0.00); C332(0.00); C394(0.00); C745(0.00)  LDD2226  [12]
TFBX
 Probe Info  		C650(0.00); C332(0.00); C38(0.00); C394(0.00)  LDD0027  [11]
WYneN
 Probe Info  		C172(0.00); C104(0.00); C1029(0.00)  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
VSF
 Probe Info  		N.A.  LDD0007  [13]
1c-yne
 Probe Info  		N.A.  LDD0228  [14]
Acrolein
 Probe Info  		C332(0.00); C38(0.00); C394(0.00); C1029(0.00)  LDD0217  [15]
Methacrolein
 Probe Info  		N.A.  LDD0218  [15]
W1
 Probe Info  		C394(0.00); C758(0.00)  LDD0236  [16]
AOyne
 Probe Info  		14.50  LDD0443  [17]
NAIA_5
 Probe Info  		C745(0.00); C332(0.00); C650(0.00); C724(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		1.00  LDD0137  [18]
STS-2
 Probe Info  		N.A.  LDD0138  [18]
Alk-rapa
 Probe Info  		18.43  LDD0213  [19]
DA-2
 Probe Info  		N.A.  LDD0071  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C172(0.68)  LDD2117  [6]
 LDCM0025  4SU-RNA HEK-293T C394(2.03)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C394(3.14); C1029(2.16)  LDD0169  [8]
 LDCM0214  AC1 HCT 116 C101(1.07); C172(1.09); C332(0.97); C650(1.06)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C101(0.93); C1029(1.00); C104(0.96); C172(1.11)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C1029(0.99); C104(0.65); C332(1.07); C650(1.19)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C1029(1.18); C104(0.68); C332(1.20); C650(0.72)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C1029(0.84); C104(0.55); C332(0.84); C650(0.71)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C1029(1.37); C104(0.60); C332(0.93); C650(0.88)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C1029(1.16); C104(0.56); C332(0.92); C650(0.88)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C1029(1.35); C104(0.63); C332(1.30); C650(0.87)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C1029(1.34); C104(0.47); C332(1.23); C650(0.76)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C1029(1.25); C104(0.50); C332(0.90); C650(0.76)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C1029(1.21); C104(0.56); C332(1.06); C650(0.89)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C1029(0.98); C104(0.59); C332(0.89); C650(0.97)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C101(0.85); C1029(1.23); C104(0.90); C172(1.31)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C1029(0.83); C104(0.52); C332(1.14); C650(0.90)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C1029(0.97); C104(0.50); C332(1.22); C650(0.89)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C1029(1.34); C104(0.64); C332(0.99); C650(0.84)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C1029(0.91); C332(0.94); C650(1.00); C758(0.91)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C1029(1.08); C332(1.04); C650(1.00); C758(0.99)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C1029(1.23); C332(0.94); C650(1.12); C758(1.07)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C1029(1.22); C332(0.98); C650(0.87); C758(1.04)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C1029(1.06); C332(1.02); C650(0.95); C758(0.98)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C1029(1.05); C332(0.99); C650(1.04); C758(0.99)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C1029(1.36); C332(1.19); C650(1.11); C758(1.07)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C101(0.89); C1029(1.09); C104(0.91); C172(1.12)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C1029(0.92); C332(0.98); C650(1.23); C758(1.03)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C1029(1.16); C332(0.79); C650(0.96); C758(1.00)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C1029(0.99); C332(0.92); C650(1.10); C758(0.95)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C1029(0.99); C332(0.88); C650(1.11); C758(0.90)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C1029(0.87); C332(0.86); C650(1.15); C758(0.90)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C1029(1.07); C332(1.03); C650(0.88); C758(0.85)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C1029(1.42); C332(1.32); C650(1.18); C758(1.00)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C1029(1.33); C332(1.03); C650(1.11); C758(0.89)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C101(0.78); C104(0.78); C172(1.27); C332(1.30)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C101(0.46); C104(0.46); C172(1.10); C332(1.17)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C101(0.77); C104(0.77); C172(1.08); C332(0.76)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C101(0.87); C104(0.87); C172(0.95); C332(1.15)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C101(0.52); C104(0.52); C172(1.08); C332(1.03)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C101(0.65); C104(0.65); C172(1.44); C332(1.03)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C101(0.63); C104(0.63); C172(1.00); C332(0.96)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C101(0.79); C104(0.79); C172(1.28); C332(1.11)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C101(0.97); C104(0.97); C172(1.20); C332(1.15)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C101(0.71); C104(0.71); C172(1.09); C332(1.09)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C101(0.84); C104(0.84); C172(1.15); C332(1.28)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C101(0.63); C104(0.63); C172(1.05); C332(1.56)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C101(0.97); C1029(0.93); C104(0.99); C172(1.29)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C101(0.74); C104(0.74); C172(1.25); C332(0.92)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C101(0.73); C104(0.73); C172(1.19); C332(0.92)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C101(0.43); C104(0.43); C172(0.98); C332(1.39)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C172(0.90); C650(1.04); C758(1.21)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C650(1.02); C172(1.22); C758(1.27)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C172(0.84); C650(1.02); C758(1.22)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C172(1.20); C758(1.31); C650(2.11)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C172(0.73); C758(1.24); C650(1.36)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C758(1.84); C650(2.07); C172(3.43)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C758(1.36); C172(1.95); C650(2.81)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C332(0.91); C650(1.02); C1029(1.05); C101(1.07)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C172(1.06); C650(1.15); C758(1.25)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C172(1.06); C758(1.25); C650(1.43)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C650(1.07); C758(1.24); C172(1.27)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C172(1.34); C758(1.89); C650(2.03)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C172(1.24); C650(0.94); C758(1.35)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C172(0.99); C650(1.26); C758(1.21)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C172(1.22); C650(1.10); C758(1.17)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C172(1.73); C650(3.20); C758(1.19)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C104(0.68); C101(0.81); C172(0.86); C332(1.03)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C104(0.81); C101(0.83); C332(0.87); C172(0.89)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C104(0.87); C172(0.89); C101(0.90); C332(1.04)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C650(0.92); C758(1.06); C332(1.12); C172(1.19)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C104(0.65); C101(0.80); C332(0.89); C172(0.90)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C104(0.66); C101(0.77); C172(1.06); C332(1.11)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C104(0.78); C101(0.86); C172(0.89); C332(0.92)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C104(0.76); C101(0.79); C332(0.87); C38(1.04)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C104(0.77); C101(0.84); C332(0.90); C172(0.97)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C38(0.55); C104(0.95); C332(1.00); C101(1.28)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C38(0.79); C104(0.95); C101(1.13); C332(1.30)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C38(0.89); C104(1.09); C101(1.16); C332(1.20)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C38(0.60); C104(0.96); C101(1.20); C332(1.39)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C38(0.67); C104(1.02); C332(1.18); C101(1.35)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C650(0.89); C332(1.12); C971(1.17); C758(1.17)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C38(0.78); C104(0.92); C101(1.16); C332(1.29)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C38(0.56); C104(0.99); C101(1.16); C332(1.26)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C38(0.71); C104(0.98); C332(1.27); C101(1.41)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C38(0.77); C332(0.96); C104(0.98); C101(1.17)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C38(0.58); C332(0.99); C101(1.13); C104(1.14)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C650(0.47); C758(0.69); C101(0.84); C104(0.84)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C650(0.65); C38(0.66); C758(0.76); C101(0.80)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C38(0.69); C101(0.76); C104(0.76); C758(0.79)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C38(0.75); C758(0.82); C101(1.00); C104(1.00)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C650(0.69); C38(0.78); C758(1.02); C101(1.19)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C650(1.08); C332(1.10); C758(1.17); C172(1.19)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C650(0.80); C758(0.96); C38(0.99); C101(1.15)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C650(0.67); C758(0.85); C101(0.96); C104(0.96)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C38(0.65); C758(1.00); C650(1.04); C101(1.05)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C650(0.69); C38(0.83); C758(0.94); C101(1.06)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C650(0.81); C758(0.90); C38(0.96); C101(1.28)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C38(0.97); C758(1.02); C101(1.18); C104(1.18)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C38(0.77); C758(0.93); C332(0.93); C1029(1.06)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C101(0.96); C104(0.96); C758(1.01); C38(1.06)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C38(0.91); C332(0.95); C758(1.04); C101(1.07)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C38(1.04); C332(1.10); C758(1.11); C101(1.25)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C332(0.97); C650(1.11); C758(1.12); C172(1.21)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C38(0.83); C332(1.05); C758(1.08); C101(1.18)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C38(0.73); C332(0.84); C1029(0.85); C101(1.03)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C38(0.94); C332(0.95); C101(0.99); C104(0.99)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C38(0.89); C758(0.98); C332(0.98); C101(1.17)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C38(0.88); C332(1.01); C101(1.06); C104(1.06)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C38(0.95); C101(1.17); C104(1.17); C758(1.21)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C38(1.12); C332(1.14); C101(1.48); C104(1.48)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C104(0.93); C650(0.95); C101(1.05)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C104(1.02); C101(1.08); C650(1.68)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C650(0.96); C101(0.97); C104(1.05)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C332(0.89); C101(0.99); C104(1.04); C1029(1.10)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C101(0.77); C104(0.79); C650(1.00)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C101(0.75); C104(0.82); C650(0.92)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C104(0.85); C101(0.87); C650(0.89)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C104(0.82); C101(0.91); C650(1.07)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C650(1.01); C104(1.05); C101(1.10)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C104(1.13); C101(1.15); C650(1.19)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C101(1.01); C650(1.03); C104(1.05)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C650(0.84); C104(1.06); C101(1.16)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C650(0.76); C101(0.92); C104(0.92); C172(1.32)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C650(0.78); C101(1.01); C104(1.01); C172(1.63)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C101(0.85); C104(0.89); C172(0.93); C650(0.93)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C101(0.92); C104(0.92); C650(0.94); C172(1.28)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C101(0.82); C104(0.82); C650(0.86); C172(1.33)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C650(0.93); C101(1.01); C104(1.01); C172(1.17)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C650(0.88); C172(1.07); C101(1.27); C104(1.27)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C650(0.93); C172(1.11); C101(1.28); C104(1.28)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C650(0.91); C172(1.17); C101(1.43); C104(1.43)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C101(0.93); C104(0.93); C650(1.08); C172(1.14)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C650(0.81); C172(0.82); C101(1.03); C104(1.03)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C172(0.73); C650(0.88); C101(0.93); C104(0.93)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C650(0.73); C101(0.89); C104(0.89); C172(1.13)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C101(0.69); C104(0.71); C650(0.98); C332(1.02)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C650(0.93); C101(1.01); C104(1.01); C172(1.35)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C101(0.80); C104(0.80); C650(0.86); C172(1.65)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C172(0.89); C650(0.90); C101(1.53); C104(1.53)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C650(1.08); C104(1.09); C332(1.18); C1029(1.66)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C650(0.90); C332(1.15); C104(1.15); C1029(1.53)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C104(1.00); C650(1.08); C332(1.11); C1029(1.27)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C650(0.94); C104(1.07); C332(1.28); C1029(1.44)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C650(0.98); C104(0.99); C332(1.10); C1029(1.53)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C650(0.98); C104(1.04); C332(1.32); C1029(1.46)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C332(1.24); C650(1.26); C104(1.27); C1029(1.57)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C104(0.88); C332(1.02); C650(1.12); C1029(2.10)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C1029(1.13); C332(1.22); C650(1.29); C104(1.32)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C104(1.04); C332(1.12); C1029(1.42); C650(1.50)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C104(0.92); C332(0.98); C650(1.04); C1029(1.27)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C650(0.77); C104(1.11); C1029(1.19); C332(1.26)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C650(1.27); C104(1.28); C332(1.29); C1029(1.35)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C1029(0.89); C332(1.09); C104(1.23); C650(1.23)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C332(1.04); C104(1.20); C650(1.25); C1029(1.79)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C104(0.59); C650(0.95); C332(1.06); C1029(3.36)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C104(0.48); C650(0.81); C1029(0.90); C332(0.95)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C101(1.09); C1029(1.20); C104(1.12); C172(1.38)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C332(0.84); C104(0.96); C101(0.98); C758(1.08)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C101(0.95); C1029(0.97); C332(0.98); C104(1.14)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C1029(1.13); C38(0.99); C104(0.92); C758(0.88)  LDD0078  [9]
 LDCM0108  Chloroacetamide HeLa C332(0.00); C745(0.00); C394(0.00)  LDD0222  [15]
 LDCM0632  CL-Sc Hep-G2 C1029(20.00); C971(1.80); C650(0.96); C758(0.88)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C172(0.65); C650(0.91); C758(0.92); C101(1.23)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C172(0.65); C650(0.93); C758(1.01); C101(1.05)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C650(0.89); C332(1.07); C758(1.08); C172(1.10)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C1029(0.89); C332(0.98); C101(1.11); C650(1.14)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C1029(0.83); C332(0.90); C650(0.91); C101(0.92)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C1029(0.92); C332(1.00); C758(1.01); C971(1.02)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C332(0.81); C758(0.93); C1029(1.01); C650(1.09)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C104(0.66); C101(0.76); C172(0.81); C332(0.95)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C104(0.70); C101(0.80); C332(1.10); C650(1.17)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C104(0.67); C101(0.79); C332(1.13); C172(1.15)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C104(0.73); C101(0.89); C650(1.03); C332(1.04)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C104(0.64); C101(0.76); C332(0.99); C172(1.01)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C172(0.51); C650(0.97); C101(1.03); C104(1.23)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C104(0.69); C101(0.77); C172(0.80); C332(1.07)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C104(0.72); C101(0.82); C38(1.03); C332(1.07)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C38(0.71); C104(0.82); C332(0.99); C101(1.00)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C38(0.69); C104(0.99); C332(1.19); C101(1.25)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C38(0.66); C104(0.80); C332(1.03); C101(1.08)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C38(0.70); C101(1.06); C104(1.07); C332(1.10)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C38(0.76); C104(0.99); C332(1.04); C101(1.36)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C38(0.83); C650(0.97); C101(1.30); C104(1.30)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C650(0.70); C38(0.75); C758(0.93); C101(1.16)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C650(0.79); C38(0.79); C758(1.04); C101(1.34)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C172(0.71); C101(1.20); C650(1.32); C758(1.42)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C758(0.80); C650(0.81); C38(0.96); C101(1.11)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C758(0.79); C332(0.85); C101(0.86); C104(0.86)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C758(0.83); C38(0.83); C1029(0.98); C332(0.99)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C101(0.91); C104(0.91); C38(0.93); C332(0.96)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C332(1.11); C38(1.11); C101(1.26); C104(1.26)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C650(0.74); C101(0.84); C104(0.87)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C104(0.96); C101(1.09); C650(1.10)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C104(0.98); C650(1.09); C101(1.11)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C104(0.84); C101(0.92); C650(1.00)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C172(0.67); C650(1.09); C101(1.09); C758(1.12)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C172(0.80); C758(0.84); C101(0.93); C650(0.93)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C650(0.65); C172(0.65); C101(0.96); C758(1.07)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C650(0.92); C101(0.96); C104(1.03); C758(1.03)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C758(0.81); C101(0.89); C104(1.05); C650(1.16)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C758(0.87); C101(0.89); C104(0.95); C650(1.30)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C758(0.94); C101(0.94); C104(1.03); C650(1.11)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C650(0.62); C172(0.76); C758(0.94); C101(1.00)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C758(1.04); C104(1.16); C101(1.22); C650(1.28)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C101(1.10); C104(1.10); C758(1.16); C650(1.80)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C101(1.33); C104(1.34); C758(1.36); C650(1.54)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C101(1.02); C758(1.03); C104(1.07); C650(1.22)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C101(1.11); C104(1.17); C758(1.33); C650(1.40)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C101(1.05); C104(1.29); C650(1.16); C758(1.05)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C101(0.93); C104(0.96); C650(1.10); C758(1.15)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C101(0.89); C104(0.98); C650(1.39); C758(0.93)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C101(0.99); C104(1.03); C650(1.24); C758(1.13)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C101(1.07); C104(1.17); C650(1.36); C758(1.18)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C101(1.08); C104(1.20); C172(1.07); C650(1.29)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C101(1.00); C104(1.05); C650(1.14); C758(0.91)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C101(0.89); C104(0.89); C332(0.92); C650(1.25)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C101(0.78); C104(0.78); C332(0.89); C38(1.19)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C101(0.81); C104(0.81); C332(0.88); C38(1.10)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C101(1.24); C104(1.24); C332(0.91); C38(2.00)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C101(1.19); C104(1.19); C332(0.94); C38(2.09)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C101(1.07); C104(1.07); C332(0.91); C38(1.82)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C101(1.35); C104(1.35); C332(0.82); C38(1.71)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C101(1.07); C104(1.07); C332(0.84); C38(1.43)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C101(1.05); C104(1.26); C172(0.77); C650(0.86)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C101(1.27); C104(1.27); C332(1.11); C38(1.36)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C101(0.95); C104(0.95); C332(0.89); C38(1.33)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C101(1.37); C104(1.37); C332(0.92); C38(2.10)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C101(1.44); C104(1.44); C332(1.05); C38(1.46)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C101(0.98); C104(0.98); C332(0.87); C38(2.18)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C101(1.03); C104(1.03); C332(0.85); C38(1.96)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C101(0.92); C104(0.95); C172(0.96); C332(1.03)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C101(1.09); C104(1.08); C172(1.07); C332(0.84)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C101(1.29); C104(1.21); C172(0.85); C332(0.84)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C101(1.29); C104(1.21); C172(0.91); C332(0.92)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C101(1.15); C104(1.28); C172(0.88); C650(1.00)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C101(1.06); C104(1.04); C172(1.13); C332(0.96)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C101(0.95); C104(1.01); C172(1.29); C332(0.84)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C101(0.94); C104(0.92); C172(1.14); C332(0.97)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C101(1.11); C104(1.08); C172(0.89); C332(0.80)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C101(0.96); C104(0.95); C172(0.55); C332(0.96)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C101(0.98); C104(1.07); C172(1.20); C332(0.91)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C101(0.90); C104(0.87); C172(1.39); C332(0.83)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C101(0.76); C104(0.77); C172(1.09); C332(0.84)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C101(1.02); C104(1.03); C172(0.83); C332(1.02)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C101(0.95); C104(0.96); C172(1.05); C332(0.91)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C101(1.11); C104(1.04); C172(1.34); C650(0.79)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C101(0.91); C104(1.01); C172(0.92); C332(1.11)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C101(1.04); C172(1.16); C332(1.17); C38(1.43)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C101(0.98); C172(1.14); C332(1.13); C38(0.91)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C101(0.87); C172(1.17); C332(1.04); C38(1.23)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C101(1.03); C172(1.23); C332(1.13); C38(1.09)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C101(1.00); C172(1.11); C332(1.12); C38(0.97)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C101(1.13); C172(1.23); C332(1.19); C38(1.11)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C101(1.16); C172(1.12); C332(1.02); C38(1.03)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C101(0.90); C172(1.19); C332(1.13); C38(0.98)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C101(1.15); C172(1.02); C332(1.21); C38(0.82)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C101(1.07); C104(1.07); C172(0.84); C650(1.09)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C101(1.25); C172(1.22); C332(1.15); C38(0.97)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C101(0.96); C172(1.26); C332(1.28); C38(0.87)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C101(0.88); C172(1.16); C332(1.27); C38(0.92)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C101(1.02); C172(1.21); C332(1.13); C38(0.80)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C101(0.98); C172(1.20); C332(1.06); C38(0.86)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C101(0.91); C332(0.82); C758(1.44); C971(0.97)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C101(0.99); C332(0.77); C758(1.27); C971(1.06)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C101(0.93); C332(0.87); C758(1.24); C971(1.07)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C101(0.97); C332(0.82); C758(1.50); C971(1.43)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C101(1.45); C104(1.53); C172(0.93); C650(1.07)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C101(0.99); C332(0.79); C758(1.29); C971(0.96)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C101(0.90); C332(0.89); C758(1.56); C971(1.18)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C101(1.24); C332(0.89); C758(2.33); C971(1.89)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C101(1.20); C332(0.79); C758(1.46); C971(1.53)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C101(1.26); C332(0.88); C758(2.14); C971(1.84)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C101(0.89); C332(0.82); C758(1.59); C971(1.17)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C101(0.96); C332(0.98); C758(1.09); C971(1.03)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C101(1.29); C332(0.76); C758(1.22); C971(1.32)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C101(1.13); C332(0.79); C758(1.34); C971(1.37)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C101(1.38); C332(0.89); C758(2.77); C971(2.07)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C101(1.43); C104(1.99); C172(0.70); C650(1.17)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C101(0.97); C332(0.83); C758(1.02); C971(0.98)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C101(1.34); C172(1.06); C332(1.15); C650(0.96)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C101(1.83); C172(0.88); C332(0.90); C650(0.88)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C101(0.97); C172(0.96); C332(1.26); C650(1.05)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C101(1.58); C172(0.85); C332(1.05); C650(1.10)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C101(1.39); C172(0.97); C332(0.93); C650(0.96)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C101(0.94); C172(1.19); C332(0.95); C650(1.09)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C101(1.42); C172(1.04); C332(1.06); C650(0.99)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C101(1.43); C172(0.98); C332(1.27); C650(0.93)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C101(1.33); C172(1.00); C332(1.18); C650(1.26)  LDD0811  [9]
 LDCM0634  CY-0357 Hep-G2 C971(1.39); C1029(1.10); C332(0.71)  LDD2228  [12]
 LDCM0028  Dobutamine HEK-293T 10.80  LDD0180  [7]
 LDCM0495  E2913 HEK-293T C1029(0.97); C650(1.02); C394(0.85); C898(0.99)  LDD1698  [21]
 LDCM0572  Fragment10 MDA-MB-231 C332(2.30)  LDD1389  [22]
 LDCM0573  Fragment11 MDA-MB-231 C971(20.00)  LDD1391  [22]
 LDCM0576  Fragment14 MDA-MB-231 C332(2.53); C971(1.19)  LDD1397  [22]
 LDCM0577  Fragment15 MDA-MB-231 C332(3.24)  LDD1399  [22]
 LDCM0579  Fragment20 MDA-MB-231 C332(2.27); C971(5.96)  LDD1402  [22]
 LDCM0580  Fragment21 MDA-MB-231 C332(1.36); C971(1.69)  LDD1404  [22]
 LDCM0582  Fragment23 MDA-MB-231 C971(1.04)  LDD1408  [22]
 LDCM0584  Fragment25 MDA-MB-231 C332(0.85); C971(1.06)  LDD1411  [22]
 LDCM0578  Fragment27 MDA-MB-231 C332(0.91); C971(0.64)  LDD1401  [22]
 LDCM0586  Fragment28 MDA-MB-231 C971(0.95)  LDD1415  [22]
 LDCM0587  Fragment29 MDA-MB-231 C332(1.14)  LDD1417  [22]
 LDCM0589  Fragment31 MDA-MB-231 C332(10.83); C971(2.52)  LDD1421  [22]
 LDCM0590  Fragment32 MDA-MB-231 C332(3.71)  LDD1423  [22]
 LDCM0468  Fragment33 HCT 116 C101(0.79); C172(1.27); C332(1.17); C38(1.28)  LDD0785  [9]
 LDCM0593  Fragment35 MDA-MB-231 C971(1.08)  LDD1429  [22]
 LDCM0596  Fragment38 MDA-MB-231 C332(1.68); C971(1.01)  LDD1433  [22]
 LDCM0566  Fragment4 MDA-MB-231 C971(9.57)  LDD1378  [22]
 LDCM0599  Fragment41 MDA-MB-231 C971(1.27)  LDD1438  [22]
 LDCM0601  Fragment43 MDA-MB-231 C332(2.49)  LDD1441  [22]
 LDCM0604  Fragment46 MDA-MB-231 C332(0.91); C971(0.80)  LDD1445  [22]
 LDCM0607  Fragment49 MDA-MB-231 C332(20.00)  LDD1448  [22]
 LDCM0608  Fragment50 MDA-MB-231 C332(4.21)  LDD1449  [22]
 LDCM0427  Fragment51 HCT 116 C101(1.37); C104(1.37); C332(1.13); C38(1.63)  LDD0744  [9]
 LDCM0611  Fragment53 MDA-MB-231 C332(1.12)  LDD1454  [22]
 LDCM0614  Fragment56 MDA-MB-231 C332(0.93)  LDD1458  [22]
 LDCM0568  Fragment6 MDA-MB-231 C332(1.29); C971(1.31)  LDD1382  [22]
 LDCM0569  Fragment7 MDA-MB-231 C332(1.66); C971(12.38)  LDD1383  [22]
 LDCM0570  Fragment8 MDA-MB-231 C971(20.00)  LDD1385  [22]
 LDCM0571  Fragment9 MDA-MB-231 C332(1.32); C971(2.05)  LDD1387  [22]
 LDCM0107  IAA HeLa H812(0.00); C172(0.00)  LDD0221  [15]
 LDCM0179  JZ128 PC-3 C38(0.00); C332(0.00)  LDD0462  [5]
 LDCM0022  KB02 MDA-MB-231 C332(4.65); C971(20.00)  LDD1374  [22]
 LDCM0023  KB03 Jurkat C172(220.21); C1029(21.90)  LDD0209  [23]
 LDCM0024  KB05 COLO792 C758(3.14); C172(2.51)  LDD3310  [24]
 LDCM0109  NEM HeLa H803(0.00); H812(0.00); H802(0.00)  LDD0223  [15]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C172(0.98)  LDD2090  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C172(0.48)  LDD2093  [6]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C172(0.72)  LDD2099  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C172(0.75)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C172(1.56)  LDD2108  [6]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C172(0.41)  LDD2109  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C172(0.79)  LDD2123  [6]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C172(0.50)  LDD2125  [6]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C172(0.69)  LDD2127  [6]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C172(0.45)  LDD2129  [6]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C172(0.89)  LDD2136  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C172(0.73)  LDD2137  [6]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C172(1.45)  LDD1700  [6]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C172(0.42)  LDD2140  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C172(0.83)  LDD2141  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C172(0.79)  LDD2146  [6]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C172(0.44)  LDD2148  [6]
 LDCM0090  Rapamycin JHH-7 18.43  LDD0213  [19]
 LDCM0021  THZ1 HeLa S3 C38(1.05)  LDD0460  [5]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
16 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
17 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
18 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
19 Rapamycin targets STAT3 and impacts c-Myc to suppress tumor growth. Cell Chem Biol. 2022 Mar 17;29(3):373-385.e6. doi: 10.1016/j.chembiol.2021.10.006. Epub 2021 Oct 26.
20 Cell-based proteome profiling of potential dasatinib targets by use of affinity-based probes. J Am Chem Soc. 2012 Feb 15;134(6):3001-14. doi: 10.1021/ja208518u. Epub 2012 Feb 1.
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
23 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840