Details of the Target

General Information of Target

Target ID LDTP03327
Target Name ATP synthase subunit alpha, mitochondrial (ATP5F1A)
Gene Name ATP5F1A
Gene ID 498
Synonyms
ATP5A; ATP5A1; ATP5AL2; ATPM; ATP synthase subunit alpha, mitochondrial; ATP synthase F1 subunit alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLSVRVAAAVVRALPRRAGLVSRNALGSSFIAARNFHASNTHLQKTGTAEMSSILEERIL
GADTSVDLEETGRVLSIGDGIARVHGLRNVQAEEMVEFSSGLKGMSLNLEPDNVGVVVFG
NDKLIKEGDIVKRTGAIVDVPVGEELLGRVVDALGNAIDGKGPIGSKTRRRVGLKAPGII
PRISVREPMQTGIKAVDSLVPIGRGQRELIIGDRQTGKTSIAIDTIINQKRFNDGSDEKK
KLYCIYVAIGQKRSTVAQLVKRLTDADAMKYTIVVSATASDAAPLQYLAPYSGCSMGEYF
RDNGKHALIIYDDLSKQAVAYRQMSLLLRRPPGREAYPGDVFYLHSRLLERAAKMNDAFG
GGSLTALPVIETQAGDVSAYIPTNVISITDGQIFLETELFYKGIRPAINVGLSVSRVGSA
AQTRAMKQVAGTMKLELAQYREVAAFAQFGSDLDAATQQLLSRGVRLTELLKQGQYSPMA
IEEQVAVIYAGVRGYLDKLEPSKITKFENAFLSHVVSQHQALLGTIRADGKISEQSDAKL
KEIVTNFLAGFEA
Target Bioclass
Transporter and channel
Family
ATPase alpha/beta chains family
Subcellular location
Mitochondrion
Function
Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Subunits alpha and beta form the catalytic core in F(1). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. Subunit alpha does not bear the catalytic high-affinity ATP-binding sites. Binds the bacterial siderophore enterobactin and can promote mitochondrial accumulation of enterobactin-derived iron ions.
Uniprot ID
P25705
Ensemble ID
ENST00000282050.6
HGNC ID
HGNC:823
ChEMBL ID
CHEMBL2062351

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO678 SNV: p.A282G DBIA    Probe Info 
JURKAT SNV: p.R405H .
RL952 SNV: p.T278M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 41 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
P2
 Probe Info  		2.40  LDD0449  [1]
P8
 Probe Info  		3.96  LDD0451  [1]
A-EBA
 Probe Info  		3.08  LDD0215  [2]
N1
 Probe Info  		5.23  LDD0242  [3]
C-Sul
 Probe Info  		3.44  LDD0066  [4]
TH211
 Probe Info  		Y311(6.56)  LDD0257  [5]
TH214
 Probe Info  		Y311(19.27); Y343(6.16)  LDD0258  [5]
TH216
 Probe Info  		Y321(15.84); Y337(14.12); Y343(12.02)  LDD0259  [5]
YN-4
 Probe Info  		100.00  LDD0445  [6]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [7]
AZ-9
 Probe Info  		E69(10.00); E50(10.00); E57(10.00)  LDD2209  [8]
ONAyne
 Probe Info  		K230(0.00); K194(0.00); K132(0.00); K175(0.00)  LDD0273  [9]
IPM
 Probe Info  		C244(0.00); C294(0.00)  LDD0241  [10]
OPA-S-S-alkyne
 Probe Info  		K434(1.73); K132(1.76); K194(1.81); K167(2.05)  LDD3494  [11]
Probe 1
 Probe Info  		Y321(87.68); Y337(7.70); Y343(10.59); Y440(33.95)  LDD3495  [12]
THZ1-DTB
 Probe Info  		C294(1.03)  LDD0460  [13]
EA-probe
 Probe Info  		C294(1.26)  LDD2210  [14]
HHS-482
 Probe Info  		Y337(0.62); Y343(0.85)  LDD0285  [15]
DBIA
 Probe Info  		C294(1.50)  LDD0078  [16]
5E-2FA
 Probe Info  		N.A.  LDD2235  [17]
AMP probe
 Probe Info  		N.A.  LDD0200  [18]
ATP probe
 Probe Info  		K531(0.00); K427(0.00); K506(0.00); K498(0.00)  LDD0199  [18]
m-APA
 Probe Info  		N.A.  LDD2231  [17]
4-Iodoacetamidophenylacetylene
 Probe Info  		C244(0.00); C294(0.00)  LDD0038  [19]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [20]
Lodoacetamide azide
 Probe Info  		C244(0.00); C294(0.00)  LDD0037  [19]
ATP probe
 Probe Info  		K230(0.00); K167(0.00); K161(0.00); K427(0.00)  LDD0035  [21]
NHS
 Probe Info  		K230(0.00); K539(0.00); K434(0.00); K506(0.00)  LDD0010  [22]
SF
 Probe Info  		K261(0.00); K531(0.00); K175(0.00); Y337(0.00)  LDD0028  [23]
STPyne
 Probe Info  		N.A.  LDD0009  [22]
TFBX
 Probe Info  		N.A.  LDD0148  [24]
1c-yne
 Probe Info  		K503(0.00); K175(0.00); K305(0.00); K218(0.00)  LDD0228  [25]
1d-yne
 Probe Info  		K472(0.00); K161(0.00)  LDD0357  [25]
Acrolein
 Probe Info  		H514(0.00); H519(0.00); H306(0.00); C244(0.00)  LDD0217  [26]
Crotonaldehyde
 Probe Info  		H306(0.00); H345(0.00); C244(0.00)  LDD0219  [26]
W1
 Probe Info  		D197(0.00); S198(0.00)  LDD0236  [10]
MPP-AC
 Probe Info  		N.A.  LDD0428  [27]
NAIA_5
 Probe Info  		N.A.  LDD2223  [28]
TER-AC
 Probe Info  		N.A.  LDD0426  [27]
TPP-AC
 Probe Info  		N.A.  LDD0427  [27]
HHS-465
 Probe Info  		N.A.  LDD2240  [29]
PAL-AfBPP Probe
Click To Hide/Show 17 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C218
 Probe Info  		15.78  LDD1892  [30]
C305
 Probe Info  		12.73  LDD1974  [30]
C326
 Probe Info  		9.71  LDD1990  [30]
C413
 Probe Info  		20.97  LDD2069  [30]
FFF probe11
 Probe Info  		5.01  LDD0471  [31]
FFF probe13
 Probe Info  		13.79  LDD0475  [31]
FFF probe14
 Probe Info  		12.38  LDD0477  [31]
FFF probe2
 Probe Info  		6.38  LDD0463  [31]
FFF probe3
 Probe Info  		14.46  LDD0464  [31]
JN0003
 Probe Info  		10.29  LDD0469  [31]
STS-2
 Probe Info  		N.A.  LDD0139  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]
BD-F
 Probe Info  		D452(0.00); V443(0.00); Q448(0.00); A444(0.00)  LDD0024  [34]
LD-F
 Probe Info  		N.A.  LDD0015  [34]
DA-2
 Probe Info  		N.A.  LDD0071  [35]
OEA-DA
 Probe Info  		5.38  LDD0046  [36]
STS-1
 Probe Info  		N.A.  LDD0069  [37]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C244(0.77); C294(0.86)  LDD0531  [16]
 LDCM0215  AC10 HCT 116 C244(1.03); C294(0.67)  LDD0532  [16]
 LDCM0216  AC100 HCT 116 C244(1.00); C294(0.80)  LDD0533  [16]
 LDCM0217  AC101 HCT 116 C244(0.96); C294(1.02)  LDD0534  [16]
 LDCM0218  AC102 HCT 116 C244(0.96); C294(1.30)  LDD0535  [16]
 LDCM0219  AC103 HCT 116 C244(0.94); C294(1.21)  LDD0536  [16]
 LDCM0220  AC104 HCT 116 C244(1.11); C294(1.16)  LDD0537  [16]
 LDCM0221  AC105 HCT 116 C244(0.95); C294(1.33)  LDD0538  [16]
 LDCM0222  AC106 HCT 116 C244(1.05); C294(1.21)  LDD0539  [16]
 LDCM0223  AC107 HCT 116 C244(1.08); C294(1.49)  LDD0540  [16]
 LDCM0224  AC108 HCT 116 C244(1.18); C294(0.72)  LDD0541  [16]
 LDCM0225  AC109 HCT 116 C244(1.16); C294(0.64)  LDD0542  [16]
 LDCM0226  AC11 HCT 116 C244(1.08); C294(0.59)  LDD0543  [16]
 LDCM0227  AC110 HCT 116 C244(1.17); C294(0.82)  LDD0544  [16]
 LDCM0228  AC111 HCT 116 C244(0.99); C294(0.92)  LDD0545  [16]
 LDCM0229  AC112 HCT 116 C244(0.86); C294(1.02)  LDD0546  [16]
 LDCM0230  AC113 HCT 116 C244(1.08); C294(0.91)  LDD0547  [16]
 LDCM0231  AC114 HCT 116 C244(0.89); C294(0.65)  LDD0548  [16]
 LDCM0232  AC115 HCT 116 C244(0.79); C294(0.65)  LDD0549  [16]
 LDCM0233  AC116 HCT 116 C244(0.88); C294(0.50)  LDD0550  [16]
 LDCM0234  AC117 HCT 116 C244(1.06); C294(0.63)  LDD0551  [16]
 LDCM0235  AC118 HCT 116 C244(1.12); C294(0.55)  LDD0552  [16]
 LDCM0236  AC119 HCT 116 C244(0.94); C294(0.44)  LDD0553  [16]
 LDCM0237  AC12 HCT 116 C244(1.25); C294(0.74)  LDD0554  [16]
 LDCM0238  AC120 HCT 116 C244(0.92); C294(0.52)  LDD0555  [16]
 LDCM0239  AC121 HCT 116 C244(1.13); C294(0.45)  LDD0556  [16]
 LDCM0240  AC122 HCT 116 C244(0.91); C294(0.48)  LDD0557  [16]
 LDCM0241  AC123 HCT 116 C244(1.61); C294(0.56)  LDD0558  [16]
 LDCM0242  AC124 HCT 116 C244(1.07); C294(0.61)  LDD0559  [16]
 LDCM0243  AC125 HCT 116 C244(0.93); C294(0.49)  LDD0560  [16]
 LDCM0244  AC126 HCT 116 C244(0.84); C294(0.50)  LDD0561  [16]
 LDCM0245  AC127 HCT 116 C244(0.87); C294(0.64)  LDD0562  [16]
 LDCM0246  AC128 HCT 116 C244(1.18)  LDD0563  [16]
 LDCM0247  AC129 HCT 116 C244(1.26)  LDD0564  [16]
 LDCM0249  AC130 HCT 116 C244(1.08)  LDD0566  [16]
 LDCM0250  AC131 HCT 116 C244(1.24)  LDD0567  [16]
 LDCM0251  AC132 HCT 116 C244(1.16)  LDD0568  [16]
 LDCM0252  AC133 HCT 116 C244(0.98)  LDD0569  [16]
 LDCM0253  AC134 HCT 116 C244(0.89)  LDD0570  [16]
 LDCM0254  AC135 HCT 116 C244(0.93)  LDD0571  [16]
 LDCM0255  AC136 HCT 116 C244(0.95)  LDD0572  [16]
 LDCM0256  AC137 HCT 116 C244(1.16)  LDD0573  [16]
 LDCM0257  AC138 HCT 116 C244(1.09)  LDD0574  [16]
 LDCM0258  AC139 HCT 116 C244(0.88)  LDD0575  [16]
 LDCM0259  AC14 HCT 116 C244(1.22); C294(0.50)  LDD0576  [16]
 LDCM0260  AC140 HCT 116 C244(0.85)  LDD0577  [16]
 LDCM0261  AC141 HCT 116 C244(0.92)  LDD0578  [16]
 LDCM0262  AC142 HCT 116 C244(1.12)  LDD0579  [16]
 LDCM0263  AC143 HCT 116 C244(0.77); C294(0.68)  LDD0580  [16]
 LDCM0264  AC144 HCT 116 C244(0.82); C294(0.83)  LDD0581  [16]
 LDCM0265  AC145 HCT 116 C294(0.75); C244(0.90)  LDD0582  [16]
 LDCM0266  AC146 HCT 116 C244(0.74); C294(0.83)  LDD0583  [16]
 LDCM0267  AC147 HCT 116 C294(0.78); C244(0.83)  LDD0584  [16]
 LDCM0268  AC148 HCT 116 C294(0.57); C244(0.64)  LDD0585  [16]
 LDCM0269  AC149 HCT 116 C294(0.63); C244(0.64)  LDD0586  [16]
 LDCM0270  AC15 HCT 116 C294(0.58); C244(1.26)  LDD0587  [16]
 LDCM0271  AC150 HCT 116 C294(0.84); C244(0.92)  LDD0588  [16]
 LDCM0272  AC151 HCT 116 C244(0.90); C294(1.06)  LDD0589  [16]
 LDCM0273  AC152 HCT 116 C244(0.71); C294(0.83)  LDD0590  [16]
 LDCM0274  AC153 HCT 116 C294(0.50); C244(0.53)  LDD0591  [16]
 LDCM0621  AC154 HCT 116 C244(0.82); C294(0.97)  LDD2158  [16]
 LDCM0622  AC155 HCT 116 C244(0.80); C294(0.86)  LDD2159  [16]
 LDCM0623  AC156 HCT 116 C244(0.87); C294(1.14)  LDD2160  [16]
 LDCM0624  AC157 HCT 116 C244(0.89); C294(1.75)  LDD2161  [16]
 LDCM0276  AC17 HCT 116 C244(1.13); C294(1.71)  LDD0593  [16]
 LDCM0277  AC18 HCT 116 C294(0.99); C244(1.07)  LDD0594  [16]
 LDCM0278  AC19 HCT 116 C244(1.04); C294(1.55)  LDD0595  [16]
 LDCM0279  AC2 HCT 116 C244(0.63); C294(0.76)  LDD0596  [16]
 LDCM0280  AC20 HCT 116 C244(1.02); C294(1.43)  LDD0597  [16]
 LDCM0281  AC21 HCT 116 C244(0.87); C294(1.08)  LDD0598  [16]
 LDCM0282  AC22 HCT 116 C244(0.92); C294(1.41)  LDD0599  [16]
 LDCM0283  AC23 HCT 116 C244(1.01); C294(1.52)  LDD0600  [16]
 LDCM0284  AC24 HCT 116 C244(1.15); C294(1.77)  LDD0601  [16]
 LDCM0285  AC25 HCT 116 C244(1.16); C294(1.32)  LDD0602  [16]
 LDCM0286  AC26 HCT 116 C294(0.91); C244(0.92)  LDD0603  [16]
 LDCM0287  AC27 HCT 116 C244(1.04); C294(1.17)  LDD0604  [16]
 LDCM0288  AC28 HCT 116 C244(0.98); C294(1.00)  LDD0605  [16]
 LDCM0289  AC29 HCT 116 C244(0.85); C294(1.21)  LDD0606  [16]
 LDCM0290  AC3 HCT 116 C244(0.59); C294(0.73)  LDD0607  [16]
 LDCM0291  AC30 HCT 116 C244(0.77); C294(1.14)  LDD0608  [16]
 LDCM0292  AC31 HCT 116 C244(0.98); C294(1.02)  LDD0609  [16]
 LDCM0293  AC32 HCT 116 C244(0.74); C294(0.81)  LDD0610  [16]
 LDCM0294  AC33 HCT 116 C294(0.99); C244(1.14)  LDD0611  [16]
 LDCM0295  AC34 HCT 116 C294(1.14); C244(1.33)  LDD0612  [16]
 LDCM0296  AC35 HCT 116 C294(1.17); C244(1.37)  LDD0613  [16]
 LDCM0297  AC36 HCT 116 C294(0.70); C244(1.12)  LDD0614  [16]
 LDCM0298  AC37 HCT 116 C294(0.54); C244(1.13)  LDD0615  [16]
 LDCM0299  AC38 HCT 116 C294(0.69); C244(1.17)  LDD0616  [16]
 LDCM0300  AC39 HCT 116 C294(0.50); C244(1.06)  LDD0617  [16]
 LDCM0301  AC4 HCT 116 C244(0.63); C294(0.75)  LDD0618  [16]
 LDCM0302  AC40 HCT 116 C294(0.68); C244(0.87)  LDD0619  [16]
 LDCM0303  AC41 HCT 116 C294(0.58); C244(1.06)  LDD0620  [16]
 LDCM0304  AC42 HCT 116 C294(0.67); C244(1.06)  LDD0621  [16]
 LDCM0305  AC43 HCT 116 C294(0.70); C244(1.16)  LDD0622  [16]
 LDCM0306  AC44 HCT 116 C294(0.66); C244(1.11)  LDD0623  [16]
 LDCM0307  AC45 HCT 116 C294(0.61); C244(0.91)  LDD0624  [16]
 LDCM0308  AC46 HCT 116 C294(0.90); C244(0.92)  LDD0625  [16]
 LDCM0309  AC47 HCT 116 C294(0.71); C244(0.86)  LDD0626  [16]
 LDCM0310  AC48 HCT 116 C294(0.64); C244(1.00)  LDD0627  [16]
 LDCM0311  AC49 HCT 116 C294(0.80); C244(1.03)  LDD0628  [16]
 LDCM0312  AC5 HCT 116 C294(0.55); C244(0.58)  LDD0629  [16]
 LDCM0313  AC50 HCT 116 C294(0.76); C244(0.81)  LDD0630  [16]
 LDCM0314  AC51 HCT 116 C294(0.77); C244(1.22)  LDD0631  [16]
 LDCM0315  AC52 HCT 116 C294(0.77); C244(0.96)  LDD0632  [16]
 LDCM0316  AC53 HCT 116 C294(0.88); C244(0.91)  LDD0633  [16]
 LDCM0317  AC54 HCT 116 C244(0.85); C294(0.88)  LDD0634  [16]
 LDCM0318  AC55 HCT 116 C244(0.79); C294(0.84)  LDD0635  [16]
 LDCM0319  AC56 HCT 116 C294(0.67); C244(0.69)  LDD0636  [16]
 LDCM0320  AC57 HCT 116 C294(0.67); C244(1.28)  LDD0637  [16]
 LDCM0321  AC58 HCT 116 C294(0.81); C244(1.09)  LDD0638  [16]
 LDCM0322  AC59 HCT 116 C294(0.65); C244(1.25)  LDD0639  [16]
 LDCM0323  AC6 HCT 116 C294(0.62); C244(0.96)  LDD0640  [16]
 LDCM0324  AC60 HCT 116 C294(0.67); C244(1.29)  LDD0641  [16]
 LDCM0325  AC61 HCT 116 C294(0.79); C244(1.58)  LDD0642  [16]
 LDCM0326  AC62 HCT 116 C294(0.81); C244(1.18)  LDD0643  [16]
 LDCM0327  AC63 HCT 116 C294(0.76); C244(1.55)  LDD0644  [16]
 LDCM0328  AC64 HCT 116 C294(0.64); C244(1.30)  LDD0645  [16]
 LDCM0329  AC65 HCT 116 C294(0.66); C244(1.65)  LDD0646  [16]
 LDCM0330  AC66 HCT 116 C294(0.83); C244(1.78)  LDD0647  [16]
 LDCM0331  AC67 HCT 116 C294(0.35); C244(1.06)  LDD0648  [16]
 LDCM0332  AC68 HCT 116 C294(0.61); C244(0.84)  LDD0649  [16]
 LDCM0333  AC69 HCT 116 C294(0.76); C244(0.79)  LDD0650  [16]
 LDCM0334  AC7 HCT 116 C294(0.68); C244(1.14)  LDD0651  [16]
 LDCM0335  AC70 HCT 116 C244(0.49); C294(0.50)  LDD0652  [16]
 LDCM0336  AC71 HCT 116 C294(0.70); C244(1.06)  LDD0653  [16]
 LDCM0337  AC72 HCT 116 C244(0.64); C294(0.87)  LDD0654  [16]
 LDCM0338  AC73 HCT 116 C244(0.39); C294(0.49)  LDD0655  [16]
 LDCM0339  AC74 HCT 116 C294(0.43); C244(0.50)  LDD0656  [16]
 LDCM0340  AC75 HCT 116 C244(0.38); C294(0.41)  LDD0657  [16]
 LDCM0341  AC76 HCT 116 C294(0.63); C244(0.75)  LDD0658  [16]
 LDCM0342  AC77 HCT 116 C294(0.56); C244(0.62)  LDD0659  [16]
 LDCM0343  AC78 HCT 116 C294(0.85); C244(0.96)  LDD0660  [16]
 LDCM0344  AC79 HCT 116 C244(0.73); C294(0.75)  LDD0661  [16]
 LDCM0345  AC8 HCT 116 C294(0.84); C244(1.10)  LDD0662  [16]
 LDCM0346  AC80 HCT 116 C294(0.60); C244(0.79)  LDD0663  [16]
 LDCM0347  AC81 HCT 116 C294(0.67); C244(0.90)  LDD0664  [16]
 LDCM0348  AC82 HCT 116 C294(0.21); C244(0.40)  LDD0665  [16]
 LDCM0349  AC83 HCT 116 C244(0.39); C294(0.67)  LDD0666  [16]
 LDCM0350  AC84 HCT 116 C244(0.50); C294(0.93)  LDD0667  [16]
 LDCM0351  AC85 HCT 116 C244(0.75); C294(0.95)  LDD0668  [16]
 LDCM0352  AC86 HCT 116 C244(0.67); C294(0.94)  LDD0669  [16]
 LDCM0353  AC87 HCT 116 C244(0.77); C294(1.22)  LDD0670  [16]
 LDCM0354  AC88 HCT 116 C244(0.69); C294(0.90)  LDD0671  [16]
 LDCM0355  AC89 HCT 116 C244(0.56); C294(1.16)  LDD0672  [16]
 LDCM0357  AC90 HCT 116 C244(0.79); C294(1.19)  LDD0674  [16]
 LDCM0358  AC91 HCT 116 C244(0.38); C294(0.86)  LDD0675  [16]
 LDCM0359  AC92 HCT 116 C244(0.43); C294(0.97)  LDD0676  [16]
 LDCM0360  AC93 HCT 116 C244(0.73); C294(1.01)  LDD0677  [16]
 LDCM0361  AC94 HCT 116 C244(0.91); C294(1.78)  LDD0678  [16]
 LDCM0362  AC95 HCT 116 C244(0.73); C294(2.51)  LDD0679  [16]
 LDCM0363  AC96 HCT 116 C244(0.59); C294(1.25)  LDD0680  [16]
 LDCM0364  AC97 HCT 116 C244(0.45); C294(1.04)  LDD0681  [16]
 LDCM0365  AC98 HCT 116 C294(0.36); C244(0.91)  LDD0682  [16]
 LDCM0366  AC99 HCT 116 C244(1.05); C294(1.61)  LDD0683  [16]
 LDCM0248  AKOS034007472 HCT 116 C244(1.25); C294(0.54)  LDD0565  [16]
 LDCM0356  AKOS034007680 HCT 116 C294(0.61); C244(1.08)  LDD0673  [16]
 LDCM0275  AKOS034007705 HCT 116 C294(0.47); C244(0.85)  LDD0592  [16]
 LDCM0020  ARS-1620 HCC44 C294(1.50)  LDD0078  [16]
 LDCM0108  Chloroacetamide HeLa H514(0.00); H519(0.00); H306(0.00); C244(0.00)  LDD0222  [26]
 LDCM0632  CL-Sc Hep-G2 C244(1.30); C244(0.73)  LDD2227  [28]
 LDCM0367  CL1 HCT 116 C244(1.02); C294(1.22)  LDD0684  [16]
 LDCM0368  CL10 HCT 116 C244(0.88); C294(0.93)  LDD0685  [16]
 LDCM0369  CL100 HCT 116 C294(0.74); C244(0.86)  LDD0686  [16]
 LDCM0370  CL101 HCT 116 C294(0.50); C244(1.08)  LDD0687  [16]
 LDCM0371  CL102 HCT 116 C294(0.68); C244(1.28)  LDD0688  [16]
 LDCM0372  CL103 HCT 116 C294(0.87); C244(1.16)  LDD0689  [16]
 LDCM0373  CL104 HCT 116 C294(0.86); C244(1.10)  LDD0690  [16]
 LDCM0374  CL105 HCT 116 C294(0.89); C244(0.92)  LDD0691  [16]
 LDCM0375  CL106 HCT 116 C244(0.79); C294(0.95)  LDD0692  [16]
 LDCM0376  CL107 HCT 116 C294(0.81); C244(1.00)  LDD0693  [16]
 LDCM0377  CL108 HCT 116 C244(0.91); C294(1.04)  LDD0694  [16]
 LDCM0378  CL109 HCT 116 C244(0.89); C294(1.20)  LDD0695  [16]
 LDCM0379  CL11 HCT 116 C244(0.88); C294(0.89)  LDD0696  [16]
 LDCM0380  CL110 HCT 116 C294(0.95); C244(0.95)  LDD0697  [16]
 LDCM0381  CL111 HCT 116 C244(0.93); C294(1.35)  LDD0698  [16]
 LDCM0382  CL112 HCT 116 C294(0.83); C244(1.02)  LDD0699  [16]
 LDCM0383  CL113 HCT 116 C244(0.92); C294(1.16)  LDD0700  [16]
 LDCM0384  CL114 HCT 116 C244(0.98); C294(1.07)  LDD0701  [16]
 LDCM0385  CL115 HCT 116 C244(1.01); C294(1.04)  LDD0702  [16]
 LDCM0386  CL116 HCT 116 C294(0.71); C244(1.19)  LDD0703  [16]
 LDCM0387  CL117 HCT 116 C294(0.53); C244(0.73)  LDD0704  [16]
 LDCM0388  CL118 HCT 116 C294(0.71); C244(1.24)  LDD0705  [16]
 LDCM0389  CL119 HCT 116 C294(0.84); C244(0.97)  LDD0706  [16]
 LDCM0390  CL12 HCT 116 C244(0.64); C294(0.86)  LDD0707  [16]
 LDCM0391  CL120 HCT 116 C294(0.53); C244(1.08)  LDD0708  [16]
 LDCM0392  CL121 HCT 116 C294(0.65); C244(1.09)  LDD0709  [16]
 LDCM0393  CL122 HCT 116 C294(0.67); C244(0.96)  LDD0710  [16]
 LDCM0394  CL123 HCT 116 C294(0.81); C244(0.83)  LDD0711  [16]
 LDCM0395  CL124 HCT 116 C244(0.76); C294(0.81)  LDD0712  [16]
 LDCM0396  CL125 HCT 116 C294(0.85); C244(1.32)  LDD0713  [16]
 LDCM0397  CL126 HCT 116 C294(0.77); C244(1.52)  LDD0714  [16]
 LDCM0398  CL127 HCT 116 C294(0.90); C244(1.49)  LDD0715  [16]
 LDCM0399  CL128 HCT 116 C294(0.64); C244(1.04)  LDD0716  [16]
 LDCM0400  CL13 HCT 116 C244(1.02); C294(1.17)  LDD0717  [16]
 LDCM0401  CL14 HCT 116 C244(0.95); C294(1.19)  LDD0718  [16]
 LDCM0402  CL15 HCT 116 C294(0.92); C244(1.05)  LDD0719  [16]
 LDCM0403  CL16 HCT 116 C244(0.73); C294(1.06)  LDD0720  [16]
 LDCM0404  CL17 HCT 116 C244(0.92); C294(0.98)  LDD0721  [16]
 LDCM0405  CL18 HCT 116 C244(1.02); C294(1.46)  LDD0722  [16]
 LDCM0406  CL19 HCT 116 C244(0.89); C294(1.07)  LDD0723  [16]
 LDCM0407  CL2 HCT 116 C244(1.05); C294(1.08)  LDD0724  [16]
 LDCM0408  CL20 HCT 116 C244(0.69); C294(1.20)  LDD0725  [16]
 LDCM0409  CL21 HCT 116 C294(0.81); C244(0.85)  LDD0726  [16]
 LDCM0410  CL22 HCT 116 C244(0.76); C294(0.83)  LDD0727  [16]
 LDCM0411  CL23 HCT 116 C244(0.78); C294(1.16)  LDD0728  [16]
 LDCM0412  CL24 HCT 116 C244(0.68); C294(1.03)  LDD0729  [16]
 LDCM0413  CL25 HCT 116 C244(0.69); C294(0.78)  LDD0730  [16]
 LDCM0414  CL26 HCT 116 C244(0.73); C294(1.24)  LDD0731  [16]
 LDCM0415  CL27 HCT 116 C244(0.91); C294(0.96)  LDD0732  [16]
 LDCM0416  CL28 HCT 116 C244(0.75); C294(0.96)  LDD0733  [16]
 LDCM0417  CL29 HCT 116 C244(0.71); C294(0.81)  LDD0734  [16]
 LDCM0418  CL3 HCT 116 C244(1.03); C294(1.22)  LDD0735  [16]
 LDCM0419  CL30 HCT 116 C244(0.85); C294(1.07)  LDD0736  [16]
 LDCM0420  CL31 HCT 116 C244(0.87); C294(1.27)  LDD0737  [16]
 LDCM0421  CL32 HCT 116 C244(0.86); C294(1.39)  LDD0738  [16]
 LDCM0422  CL33 HCT 116 C244(0.91); C294(1.65)  LDD0739  [16]
 LDCM0423  CL34 HCT 116 C244(0.99); C294(1.10)  LDD0740  [16]
 LDCM0424  CL35 HCT 116 C244(0.76); C294(1.61)  LDD0741  [16]
 LDCM0425  CL36 HCT 116 C244(1.51); C294(1.61)  LDD0742  [16]
 LDCM0426  CL37 HCT 116 C244(0.64); C294(1.53)  LDD0743  [16]
 LDCM0428  CL39 HCT 116 C244(0.74); C294(1.19)  LDD0745  [16]
 LDCM0429  CL4 HCT 116 C244(0.92); C294(1.07)  LDD0746  [16]
 LDCM0430  CL40 HCT 116 C244(0.76); C294(1.56)  LDD0747  [16]
 LDCM0431  CL41 HCT 116 C244(1.33); C294(1.47)  LDD0748  [16]
 LDCM0432  CL42 HCT 116 C244(1.28); C294(0.97)  LDD0749  [16]
 LDCM0433  CL43 HCT 116 C244(0.87); C294(1.73)  LDD0750  [16]
 LDCM0434  CL44 HCT 116 C244(0.97); C294(1.65)  LDD0751  [16]
 LDCM0435  CL45 HCT 116 C244(0.92); C294(1.06)  LDD0752  [16]
 LDCM0436  CL46 HCT 116 C244(0.91); C294(1.69)  LDD0753  [16]
 LDCM0437  CL47 HCT 116 C244(0.91); C294(1.14)  LDD0754  [16]
 LDCM0438  CL48 HCT 116 C244(0.98); C294(1.45)  LDD0755  [16]
 LDCM0439  CL49 HCT 116 C244(1.30); C294(2.10)  LDD0756  [16]
 LDCM0440  CL5 HCT 116 C244(1.05); C294(1.19)  LDD0757  [16]
 LDCM0441  CL50 HCT 116 C244(0.89); C294(1.32)  LDD0758  [16]
 LDCM0442  CL51 HCT 116 C244(0.92); C294(1.45)  LDD0759  [16]
 LDCM0443  CL52 HCT 116 C244(0.71); C294(1.20)  LDD0760  [16]
 LDCM0444  CL53 HCT 116 C244(0.79); C294(2.12)  LDD0761  [16]
 LDCM0445  CL54 HCT 116 C244(0.82); C294(1.34)  LDD0762  [16]
 LDCM0446  CL55 HCT 116 C244(1.02); C294(2.11)  LDD0763  [16]
 LDCM0447  CL56 HCT 116 C244(1.03); C294(1.12)  LDD0764  [16]
 LDCM0448  CL57 HCT 116 C244(1.16); C294(1.39)  LDD0765  [16]
 LDCM0449  CL58 HCT 116 C244(1.08); C294(1.49)  LDD0766  [16]
 LDCM0450  CL59 HCT 116 C244(0.99); C294(1.28)  LDD0767  [16]
 LDCM0451  CL6 HCT 116 C244(1.02); C294(1.00)  LDD0768  [16]
 LDCM0452  CL60 HCT 116 C244(0.92); C294(1.99)  LDD0769  [16]
 LDCM0453  CL61 HCT 116 C244(1.04); C294(0.69)  LDD0770  [16]
 LDCM0454  CL62 HCT 116 C244(1.02); C294(0.73)  LDD0771  [16]
 LDCM0455  CL63 HCT 116 C244(0.89); C294(0.43)  LDD0772  [16]
 LDCM0456  CL64 HCT 116 C244(1.06); C294(0.74)  LDD0773  [16]
 LDCM0457  CL65 HCT 116 C244(1.15); C294(0.86)  LDD0774  [16]
 LDCM0458  CL66 HCT 116 C244(1.16); C294(0.45)  LDD0775  [16]
 LDCM0459  CL67 HCT 116 C244(1.00); C294(0.43)  LDD0776  [16]
 LDCM0460  CL68 HCT 116 C244(0.81); C294(0.44)  LDD0777  [16]
 LDCM0461  CL69 HCT 116 C244(0.93); C294(0.73)  LDD0778  [16]
 LDCM0462  CL7 HCT 116 C244(0.94); C294(0.95)  LDD0779  [16]
 LDCM0463  CL70 HCT 116 C244(1.00); C294(0.66)  LDD0780  [16]
 LDCM0464  CL71 HCT 116 C244(0.87); C294(0.41)  LDD0781  [16]
 LDCM0465  CL72 HCT 116 C244(0.91); C294(0.86)  LDD0782  [16]
 LDCM0466  CL73 HCT 116 C244(0.88); C294(0.70)  LDD0783  [16]
 LDCM0467  CL74 HCT 116 C244(0.92); C294(0.66)  LDD0784  [16]
 LDCM0469  CL76 HCT 116 C244(0.83); C294(1.05)  LDD0786  [16]
 LDCM0470  CL77 HCT 116 C244(0.66); C294(2.31)  LDD0787  [16]
 LDCM0471  CL78 HCT 116 C244(0.84); C294(0.83)  LDD0788  [16]
 LDCM0472  CL79 HCT 116 C244(0.77); C294(1.14)  LDD0789  [16]
 LDCM0473  CL8 HCT 116 C244(0.85); C294(1.05)  LDD0790  [16]
 LDCM0474  CL80 HCT 116 C244(0.90); C294(1.46)  LDD0791  [16]
 LDCM0475  CL81 HCT 116 C244(0.83); C294(0.90)  LDD0792  [16]
 LDCM0476  CL82 HCT 116 C244(1.12); C294(0.76)  LDD0793  [16]
 LDCM0477  CL83 HCT 116 C244(0.66); C294(0.83)  LDD0794  [16]
 LDCM0478  CL84 HCT 116 C244(0.71); C294(0.62)  LDD0795  [16]
 LDCM0479  CL85 HCT 116 C244(0.80); C294(0.97)  LDD0796  [16]
 LDCM0480  CL86 HCT 116 C244(1.03); C294(1.03)  LDD0797  [16]
 LDCM0481  CL87 HCT 116 C244(0.85); C294(0.91)  LDD0798  [16]
 LDCM0482  CL88 HCT 116 C244(1.00); C294(0.77)  LDD0799  [16]
 LDCM0483  CL89 HCT 116 C244(0.90); C294(0.55)  LDD0800  [16]
 LDCM0484  CL9 HCT 116 C244(1.01); C294(1.14)  LDD0801  [16]
 LDCM0485  CL90 HCT 116 C244(0.90); C294(0.81)  LDD0802  [16]
 LDCM0486  CL91 HCT 116 C244(0.53); C294(0.57)  LDD0803  [16]
 LDCM0487  CL92 HCT 116 C244(0.66); C294(0.54)  LDD0804  [16]
 LDCM0488  CL93 HCT 116 C244(0.74); C294(0.60)  LDD0805  [16]
 LDCM0489  CL94 HCT 116 C244(0.78); C294(0.49)  LDD0806  [16]
 LDCM0490  CL95 HCT 116 C244(0.68); C294(0.45)  LDD0807  [16]
 LDCM0491  CL96 HCT 116 C244(0.52); C294(0.49)  LDD0808  [16]
 LDCM0492  CL97 HCT 116 C244(0.67); C294(0.64)  LDD0809  [16]
 LDCM0493  CL98 HCT 116 C244(0.51); C294(0.58)  LDD0810  [16]
 LDCM0494  CL99 HCT 116 C244(0.79); C294(0.68)  LDD0811  [16]
 LDCM0495  E2913 HEK-293T C244(1.06); C294(1.03)  LDD1698  [38]
 LDCM0175  Ethacrynic acid HeLa C294(1.26)  LDD2210  [14]
 LDCM0572  Fragment10 MDA-MB-231 C294(3.67)  LDD1389  [39]
 LDCM0573  Fragment11 MDA-MB-231 C294(1.55)  LDD1391  [39]
 LDCM0574  Fragment12 MDA-MB-231 C294(2.60)  LDD1393  [39]
 LDCM0575  Fragment13 MDA-MB-231 C294(1.18)  LDD1395  [39]
 LDCM0576  Fragment14 MDA-MB-231 C294(1.81)  LDD1397  [39]
 LDCM0579  Fragment20 MDA-MB-231 C294(20.00)  LDD1402  [39]
 LDCM0580  Fragment21 MDA-MB-231 C294(1.54)  LDD1404  [39]
 LDCM0581  Fragment22 MDA-MB-231 C294(1.13)  LDD1406  [39]
 LDCM0582  Fragment23 MDA-MB-231 C294(2.16)  LDD1408  [39]
 LDCM0585  Fragment26 Ramos C294(1.05)  LDD1412  [39]
 LDCM0578  Fragment27 MDA-MB-231 C294(1.02)  LDD1401  [39]
 LDCM0586  Fragment28 MDA-MB-231 C294(1.17)  LDD1415  [39]
 LDCM0587  Fragment29 MDA-MB-231 C294(1.25)  LDD1417  [39]
 LDCM0588  Fragment30 Ramos C294(1.63)  LDD1420  [39]
 LDCM0589  Fragment31 MDA-MB-231 C294(3.21)  LDD1421  [39]
 LDCM0590  Fragment32 MDA-MB-231 C294(1.63)  LDD1423  [39]
 LDCM0468  Fragment33 HCT 116 C244(1.06); C294(0.45)  LDD0785  [16]
 LDCM0592  Fragment34 Ramos C294(1.17)  LDD1428  [39]
 LDCM0595  Fragment37 Ramos C294(1.01)  LDD1432  [39]
 LDCM0596  Fragment38 MDA-MB-231 C294(0.96)  LDD1433  [39]
 LDCM0566  Fragment4 MDA-MB-231 C294(2.00)  LDD1378  [39]
 LDCM0598  Fragment40 Ramos C294(0.68)  LDD1437  [39]
 LDCM0599  Fragment41 MDA-MB-231 C294(1.01)  LDD1438  [39]
 LDCM0600  Fragment42 Ramos C294(1.04)  LDD1440  [39]
 LDCM0601  Fragment43 MDA-MB-231 C294(1.98)  LDD1441  [39]
 LDCM0602  Fragment44 MDA-MB-231 C294(0.93)  LDD1443  [39]
 LDCM0604  Fragment46 MDA-MB-231 C294(0.76)  LDD1445  [39]
 LDCM0605  Fragment47 MDA-MB-231 C294(1.08)  LDD1446  [39]
 LDCM0606  Fragment48 MDA-MB-231 C294(1.02)  LDD1447  [39]
 LDCM0607  Fragment49 MDA-MB-231 C294(2.02)  LDD1448  [39]
 LDCM0427  Fragment51 HCT 116 C244(0.91); C294(0.92)  LDD0744  [16]
 LDCM0610  Fragment52 MDA-MB-231 C294(1.32)  LDD1452  [39]
 LDCM0611  Fragment53 MDA-MB-231 C294(1.00)  LDD1454  [39]
 LDCM0612  Fragment54 MDA-MB-231 C294(1.00)  LDD1456  [39]
 LDCM0613  Fragment55 MDA-MB-231 C294(1.40)  LDD1457  [39]
 LDCM0614  Fragment56 MDA-MB-231 C294(1.00)  LDD1458  [39]
 LDCM0568  Fragment6 MDA-MB-231 C294(1.27)  LDD1382  [39]
 LDCM0570  Fragment8 MDA-MB-231 C294(2.16)  LDD1385  [39]
 LDCM0571  Fragment9 MDA-MB-231 C294(3.16)  LDD1387  [39]
 LDCM0107  IAA HeLa H519(0.00); H306(0.00); H514(0.00); H345(0.00)  LDD0221  [26]
 LDCM0123  JWB131 DM93 Y337(0.62); Y343(0.85)  LDD0285  [15]
 LDCM0124  JWB142 DM93 Y337(1.42); Y343(0.82)  LDD0286  [15]
 LDCM0125  JWB146 DM93 Y337(0.76); Y343(1.44)  LDD0287  [15]
 LDCM0126  JWB150 DM93 Y337(4.40); Y343(2.68)  LDD0288  [15]
 LDCM0127  JWB152 DM93 Y337(1.42); Y343(1.80)  LDD0289  [15]
 LDCM0128  JWB198 DM93 Y337(1.03); Y343(1.65)  LDD0290  [15]
 LDCM0129  JWB202 DM93 Y337(0.74)  LDD0291  [15]
 LDCM0130  JWB211 DM93 Y337(1.00); Y343(0.95)  LDD0292  [15]
 LDCM0022  KB02 HCT 116 C244(1.50)  LDD0080  [16]
 LDCM0023  KB03 HCT 116 C244(1.82)  LDD0081  [16]
 LDCM0024  KB05 HCT 116 C244(2.37)  LDD0082  [16]
 LDCM0109  NEM HeLa H519(0.00); H514(0.00); H306(0.00); H345(0.00)  LDD0223  [26]
 LDCM0627  NUDT7-COV-1 HEK-293T C294(1.39)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C294(1.03)  LDD2207  [40]
 LDCM0021  THZ1 HeLa S3 C294(1.03)  LDD0460  [13]
 LDCM0110  W12 Hep-G2 K427(0.56); Q428(0.56)  LDD0237  [10]
 LDCM0111  W14 Hep-G2 Q536(0.61)  LDD0238  [10]
 LDCM0112  W16 Hep-G2 R262(0.89)  LDD0239  [10]
 LDCM0113  W17 Hep-G2 D197(0.56); S198(0.56); R262(0.57); K261(0.59)  LDD0240  [10]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase subunit beta, mitochondrial (ATP5F1B) ATPase alpha/beta chains family P06576
NAD-dependent protein deacetylase sirtuin-3, mitochondrial (SIRT3) Sirtuin family Q9NTG7
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
14-3-3 protein zeta/delta (YWHAZ) 14-3-3 family P63104
ATP synthase subunit O, mitochondrial (ATP5PO) ATPase delta chain family P48047
ATP synthase F(0) complex subunit B1, mitochondrial (ATP5PB) Eukaryotic ATPase B chain family P24539
ATP synthase-coupling factor 6, mitochondrial (ATP5PF) Eukaryotic ATPase subunit F6 family P18859
Huntingtin (HTT) Huntingtin family P42858
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase mitochondrial F1 complex assembly factor 2 (ATPAF2) ATP12 family Q8N5M1
Biogenesis of lysosome-related organelles complex 1 subunit 1 (BLOC1S1) BLOC1S1 family P78537

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Investigative
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Piceatannol Small molecular drug DB08399
Quercetin Small molecular drug DB04216
1-acetyl-2-carboxypiperidine . DB07384
Aurovertin B . DB07394
N1-(2-amino-4-methylpentyl)Octahydro-pyrrolo[12-a] Pyrimidine . DB08629

References

1 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Low-Toxicity Sulfonium-Based Probes for Cysteine-Specific Profiling in Live Cells. Anal Chem. 2022 Mar 15;94(10):4366-4372. doi: 10.1021/acs.analchem.1c05129. Epub 2022 Mar 4.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
7 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
8 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
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