Details of the Target

General Information of Target

Target ID LDTP08769
Target Name Nuclear pore complex protein Nup93 (NUP93)
Gene Name NUP93
Gene ID 9688
Synonyms
KIAA0095; Nuclear pore complex protein Nup93; 93 kDa nucleoporin; Nucleoporin Nup93
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDTEGFGELLQQAEQLAAETEGISELPHVERNLQEIQQAGERLRSRTLTRTSQETADVKA
SVLLGSRGLDISHISQRLESLSAATTFEPLEPVKDTDIQGFLKNEKDNALLSAIEESRKR
TFGMAEEYHRESMLVEWEQVKQRILHTLLASGEDALDFTQESEPSYISDVGPPGRSSLDN
IEMAYARQIYIYNEKIVNGHLQPNLVDLCASVAELDDKSISDMWTMVKQMTDVLLTPATD
ALKNRSSVEVRMEFVRQALAYLEQSYKNYTLVTVFGNLHQAQLGGVPGTYQLVRSFLNIK
LPAPLPGLQDGEVEGHPVWALIYYCMRCGDLLAASQVVNRAQHQLGEFKTWFQEYMNSKD
RRLSPATENKLRLHYRRALRNNTDPYKRAVYCIIGRCDVTDNQSEVADKTEDYLWLKLNQ
VCFDDDGTSSPQDRLTLSQFQKQLLEDYGESHFTVNQQPFLYFQVLFLTAQFEAAVAFLF
RMERLRCHAVHVALVLFELKLLLKSSGQSAQLLSHEPGDPPCLRRLNFVRLLMLYTRKFE
STDPREALQYFYFLRDEKDSQGENMFLRCVSELVIESREFDMILGKLENDGSRKPGVIDK
FTSDTKPIINKVASVAENKGLFEEAAKLYDLAKNADKVLELMNKLLSPVVPQISAPQSNK
ERLKNMALSIAERYRAQGISANKFVDSTFYLLLDLITFFDEYHSGHIDRAFDIIERLKLV
PLNQESVEERVAAFRNFSDEIRHNLSEVLLATMNILFTQFKRLKGTSPSSSSRPQRVIED
RDSQLRSQARTLITFAGMIPYRTSGDTNARLVQMEVLMN
Target Bioclass
Transporter and channel
Family
Nucleoporin interacting component (NIC) family
Subcellular location
Nucleus membrane
Function
Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance. May anchor nucleoporins, but not NUP153 and TPR, to the NPC. During renal development, regulates podocyte migration and proliferation through SMAD4 signaling.
Uniprot ID
Q8N1F7
Ensemble ID
ENST00000308159.10
HGNC ID
HGNC:28958

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.S505Y DBIA    Probe Info 
CCK81 SNV: p.K606M DBIA    Probe Info 
COLO792 SNV: p.L63H DBIA    Probe Info 
HGC27 SNV: p.A125P DBIA    Probe Info 
JVM3 SNV: p.R810W DBIA    Probe Info 
KU1919 SNV: p.H129L DBIA    Probe Info 
NCIH1299 SNV: p.M565I m-APA    Probe Info 
NCIH2291 SNV: p.P800S DBIA    Probe Info 
SNGM SNV: p.R376C DBIA    Probe Info 
SUPT1 Deletion: p.F440SfsTer16 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 48 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		8.65  LDD0402  [1]
A-EBA
 Probe Info  		3.62  LDD0215  [2]
11RK72
 Probe Info  		4.77  LDD0327  [3]
11RK73
 Probe Info  		4.25  LDD0328  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
N1
 Probe Info  		100.00  LDD0242  [4]
W1
 Probe Info  		19.48  LDD0235  [5]
TH211
 Probe Info  		Y801(13.76); Y128(5.72); Y391(5.55); Y413(5.41)  LDD0257  [6]
TH216
 Probe Info  		Y386(15.34); Y801(15.24)  LDD0259  [6]
YN-1
 Probe Info  		100.00  LDD0444  [7]
ONAyne
 Probe Info  		K370(0.00); K106(0.00); K718(0.00); K59(0.00)  LDD0273  [8]
BTD
 Probe Info  		C522(0.98)  LDD2090  [9]
AHL-Pu-1
 Probe Info  		C422(2.07)  LDD0168  [10]
EA-probe
 Probe Info  		N.A.  LDD0440  [11]
HHS-475
 Probe Info  		Y386(0.16); Y166(0.74)  LDD0264  [12]
DBIA
 Probe Info  		C422(1.10); C522(1.03); C392(0.98)  LDD0078  [13]
AMP probe
 Probe Info  		N.A.  LDD0200  [14]
ATP probe
 Probe Info  		K106(0.00); K718(0.00); K586(0.00); K370(0.00)  LDD0199  [14]
1d-yne
 Probe Info  		N.A.  LDD0358  [15]
4-Iodoacetamidophenylacetylene
 Probe Info  		C397(0.00); C328(0.00); C569(0.00); C209(0.00)  LDD0038  [16]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [17]
IPIAA_H
 Probe Info  		C325(0.00); C397(0.00)  LDD0030  [18]
IPIAA_L
 Probe Info  		C209(0.00); C325(0.00); C422(0.00); C397(0.00)  LDD0031  [18]
Lodoacetamide azide
 Probe Info  		C392(0.00); C397(0.00); C328(0.00); C569(0.00)  LDD0037  [16]
TFBX
 Probe Info  		C569(0.00); C392(0.00); C328(0.00)  LDD0027  [19]
WYneN
 Probe Info  		C522(0.00); C328(0.00); C422(0.00)  LDD0021  [20]
WYneO
 Probe Info  		N.A.  LDD0022  [20]
aHNE
 Probe Info  		N.A.  LDD0001  [20]
Compound 10
 Probe Info  		C209(0.00); C522(0.00)  LDD2216  [21]
Compound 11
 Probe Info  		N.A.  LDD2213  [21]
ENE
 Probe Info  		C522(0.00); C422(0.00)  LDD0006  [20]
IPM
 Probe Info  		C392(0.00); C522(0.00)  LDD0005  [20]
NHS
 Probe Info  		K619(0.00); K106(0.00); K370(0.00)  LDD0010  [20]
NPM
 Probe Info  		N.A.  LDD0016  [20]
PF-06672131
 Probe Info  		N.A.  LDD0017  [22]
STPyne
 Probe Info  		K106(0.00); K660(0.00); K718(0.00); K619(0.00)  LDD0009  [20]
VSF
 Probe Info  		C328(0.00); C422(0.00); C522(0.00)  LDD0007  [20]
Phosphinate-6
 Probe Info  		C487(0.00); C522(0.00)  LDD0018  [23]
Ox-W18
 Probe Info  		W351(0.00); W137(0.00)  LDD2175  [24]
1c-yne
 Probe Info  		K718(0.00); K59(0.00); K106(0.00); K349(0.00)  LDD0228  [15]
Acrolein
 Probe Info  		H146(0.00); C422(0.00); H343(0.00); H129(0.00)  LDD0217  [25]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [25]
Crotonaldehyde
 Probe Info  		C422(0.00); C392(0.00); H343(0.00); H129(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		N.A.  LDD0218  [25]
AOyne
 Probe Info  		6.30  LDD0443  [26]
NAIA_5
 Probe Info  		C397(0.00); C569(0.00)  LDD2223  [27]
HHS-482
 Probe Info  		Y166(0.71); Y190(0.89)  LDD2239  [28]
PAL-AfBPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C082
 Probe Info  		6.50  LDD1774  [29]
C218
 Probe Info  		11.71  LDD1892  [29]
C269
 Probe Info  		5.86  LDD1939  [29]
C277
 Probe Info  		7.52  LDD1947  [29]
C296
 Probe Info  		11.31  LDD1966  [29]
C338
 Probe Info  		12.91  LDD2001  [29]
C350
 Probe Info  		22.78  LDD2011  [29]
C383
 Probe Info  		21.86  LDD2042  [29]
C391
 Probe Info  		13.74  LDD2050  [29]
C420
 Probe Info  		10.20  LDD2075  [29]
FFF probe11
 Probe Info  		17.49  LDD0471  [30]
FFF probe13
 Probe Info  		20.00  LDD0475  [30]
FFF probe14
 Probe Info  		19.41  LDD0477  [30]
FFF probe2
 Probe Info  		12.35  LDD0463  [30]
FFF probe3
 Probe Info  		8.40  LDD0464  [30]
FFF probe4
 Probe Info  		12.11  LDD0466  [30]
FFF probe6
 Probe Info  		6.81  LDD0467  [30]
JN0003
 Probe Info  		20.00  LDD0469  [30]
STS-1
 Probe Info  		N.A.  LDD0136  [31]
STS-2
 Probe Info  		N.A.  LDD0138  [31]
VE-P
 Probe Info  		N.A.  LDD0396  [32]
Staurosporine capture compound
 Probe Info  		N.A.  LDD0083  [33]
DA-2
 Probe Info  		N.A.  LDD0071  [34]
OEA-DA
 Probe Info  		4.34  LDD0046  [35]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C522(0.96)  LDD2142  [9]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C522(1.01)  LDD2112  [9]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C522(0.93)  LDD2117  [9]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C522(1.08)  LDD2152  [9]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C522(0.79)  LDD2103  [9]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C522(0.87)  LDD2132  [9]
 LDCM0025  4SU-RNA HEK-293T C422(2.07)  LDD0168  [10]
 LDCM0214  AC1 HCT 116 C522(0.95); C422(1.27); C328(1.10); C392(0.67)  LDD0531  [13]
 LDCM0215  AC10 HCT 116 C522(0.98); C422(1.27); C328(0.94); C392(0.98)  LDD0532  [13]
 LDCM0216  AC100 HCT 116 C522(1.19); C422(1.06); C328(1.13); C392(0.99)  LDD0533  [13]
 LDCM0217  AC101 HCT 116 C522(1.08); C422(1.03); C328(1.00); C392(0.78)  LDD0534  [13]
 LDCM0218  AC102 HCT 116 C522(1.02); C422(1.05); C328(0.97); C392(0.65)  LDD0535  [13]
 LDCM0219  AC103 HCT 116 C522(1.19); C422(1.17); C328(0.92); C392(0.81)  LDD0536  [13]
 LDCM0220  AC104 HCT 116 C522(1.07); C422(1.11); C328(1.07); C392(0.73)  LDD0537  [13]
 LDCM0221  AC105 HCT 116 C522(1.09); C422(1.25); C328(0.91); C392(0.74)  LDD0538  [13]
 LDCM0222  AC106 HCT 116 C522(1.11); C422(1.22); C328(0.91); C392(0.91)  LDD0539  [13]
 LDCM0223  AC107 HCT 116 C522(0.97); C422(1.21); C328(1.01); C392(0.74)  LDD0540  [13]
 LDCM0224  AC108 HCT 116 C522(1.06); C422(1.05); C328(0.89); C392(0.71)  LDD0541  [13]
 LDCM0225  AC109 HCT 116 C522(0.83); C422(0.87); C328(0.96); C392(0.92)  LDD0542  [13]
 LDCM0226  AC11 HCT 116 C522(1.04); C422(1.38); C328(0.83); C392(0.99)  LDD0543  [13]
 LDCM0227  AC110 HCT 116 C522(0.97); C422(1.08); C328(0.93); C392(0.81)  LDD0544  [13]
 LDCM0228  AC111 HCT 116 C522(0.92); C422(1.05); C328(0.95); C392(0.78)  LDD0545  [13]
 LDCM0229  AC112 HCT 116 C522(0.94); C422(1.17); C328(0.84); C392(0.70)  LDD0546  [13]
 LDCM0230  AC113 HCT 116 C522(1.07); C422(1.16); C328(1.03); C392(1.00)  LDD0547  [13]
 LDCM0231  AC114 HCT 116 C522(1.13); C422(1.28); C328(1.03); C392(1.14)  LDD0548  [13]
 LDCM0232  AC115 HCT 116 C522(1.28); C422(1.45); C328(1.11); C392(1.05)  LDD0549  [13]
 LDCM0233  AC116 HCT 116 C522(1.21); C422(1.38); C328(0.94); C392(0.82)  LDD0550  [13]
 LDCM0234  AC117 HCT 116 C522(1.15); C422(1.49); C328(1.22); C392(0.93)  LDD0551  [13]
 LDCM0235  AC118 HCT 116 C522(1.06); C422(1.34); C328(1.01); C392(0.97)  LDD0552  [13]
 LDCM0236  AC119 HCT 116 C522(1.03); C422(1.44); C328(0.94); C392(0.86)  LDD0553  [13]
 LDCM0237  AC12 HCT 116 C522(1.01); C422(1.22); C328(0.79); C392(0.80)  LDD0554  [13]
 LDCM0238  AC120 HCT 116 C522(1.15); C422(1.52); C328(0.63); C392(1.45)  LDD0555  [13]
 LDCM0239  AC121 HCT 116 C522(1.16); C422(1.47); C328(1.03); C392(1.79)  LDD0556  [13]
 LDCM0240  AC122 HCT 116 C522(1.01); C422(1.21); C328(0.96); C392(0.98)  LDD0557  [13]
 LDCM0241  AC123 HCT 116 C522(1.00); C422(1.34); C328(1.02); C392(2.08)  LDD0558  [13]
 LDCM0242  AC124 HCT 116 C522(1.16); C422(1.41); C328(1.10); C392(1.36)  LDD0559  [13]
 LDCM0243  AC125 HCT 116 C522(1.15); C422(1.23); C328(1.05); C392(1.25)  LDD0560  [13]
 LDCM0244  AC126 HCT 116 C522(1.41); C422(1.32); C328(1.02); C392(1.72)  LDD0561  [13]
 LDCM0245  AC127 HCT 116 C522(1.22); C422(1.34); C328(1.23); C392(1.36)  LDD0562  [13]
 LDCM0246  AC128 HCT 116 C522(1.18); C422(1.31); C328(1.34); C392(1.01)  LDD0563  [13]
 LDCM0247  AC129 HCT 116 C522(1.12); C422(1.05); C328(1.31); C392(1.21)  LDD0564  [13]
 LDCM0249  AC130 HCT 116 C522(1.24); C422(1.35); C328(1.68); C392(1.12)  LDD0566  [13]
 LDCM0250  AC131 HCT 116 C522(1.04); C422(1.01); C328(1.65); C392(1.47)  LDD0567  [13]
 LDCM0251  AC132 HCT 116 C522(1.17); C422(1.10); C328(1.50); C392(0.90)  LDD0568  [13]
 LDCM0252  AC133 HCT 116 C522(1.14); C422(1.28); C328(1.46); C392(1.21)  LDD0569  [13]
 LDCM0253  AC134 HCT 116 C522(1.30); C422(1.31); C328(1.46); C392(0.92)  LDD0570  [13]
 LDCM0254  AC135 HCT 116 C522(1.15); C422(1.35); C328(1.51); C392(0.82)  LDD0571  [13]
 LDCM0255  AC136 HCT 116 C522(1.18); C422(1.52); C328(1.10); C392(0.94)  LDD0572  [13]
 LDCM0256  AC137 HCT 116 C522(1.15); C422(1.49); C328(0.98); C392(1.03)  LDD0573  [13]
 LDCM0257  AC138 HCT 116 C522(1.53); C422(1.62); C328(1.32); C392(0.85)  LDD0574  [13]
 LDCM0258  AC139 HCT 116 C522(1.46); C422(1.51); C328(1.50); C392(0.78)  LDD0575  [13]
 LDCM0259  AC14 HCT 116 C522(1.03); C422(1.30); C328(0.91); C392(1.17)  LDD0576  [13]
 LDCM0260  AC140 HCT 116 C522(1.63); C422(1.55); C328(1.65); C392(0.98)  LDD0577  [13]
 LDCM0261  AC141 HCT 116 C522(1.58); C422(1.54); C328(1.73); C392(0.99)  LDD0578  [13]
 LDCM0262  AC142 HCT 116 C522(1.11); C422(1.38); C328(1.49); C392(0.87)  LDD0579  [13]
 LDCM0263  AC143 HCT 116 C522(1.12); C422(1.12); C328(0.84); C569(0.91)  LDD0580  [13]
 LDCM0264  AC144 HCT 116 C569(0.90); C392(0.94); C328(0.95); C522(1.02)  LDD0581  [13]
 LDCM0265  AC145 HCT 116 C328(0.83); C392(0.86); C522(0.87); C569(1.07)  LDD0582  [13]
 LDCM0266  AC146 HCT 116 C328(0.78); C522(0.89); C569(0.94); C392(0.98)  LDD0583  [13]
 LDCM0267  AC147 HCT 116 C569(0.83); C522(0.89); C392(0.93); C328(1.06)  LDD0584  [13]
 LDCM0268  AC148 HCT 116 C522(0.87); C328(0.96); C569(1.19); C392(1.20)  LDD0585  [13]
 LDCM0269  AC149 HCT 116 C328(0.95); C569(0.96); C392(0.99); C522(1.01)  LDD0586  [13]
 LDCM0270  AC15 HCT 116 C397(0.85); C392(0.92); C328(0.93); C569(1.02)  LDD0587  [13]
 LDCM0271  AC150 HCT 116 C328(0.84); C392(0.87); C522(0.97); C569(1.04)  LDD0588  [13]
 LDCM0272  AC151 HCT 116 C392(0.90); C328(0.97); C569(1.00); C522(1.03)  LDD0589  [13]
 LDCM0273  AC152 HCT 116 C328(0.75); C522(0.84); C569(0.88); C392(1.09)  LDD0590  [13]
 LDCM0274  AC153 HCT 116 C328(0.93); C522(0.96); C569(1.19); C392(1.38)  LDD0591  [13]
 LDCM0621  AC154 HCT 116 C522(0.95); C422(1.42); C328(0.98); C392(1.03)  LDD2158  [13]
 LDCM0622  AC155 HCT 116 C522(0.98); C422(1.51); C328(0.72); C392(0.95)  LDD2159  [13]
 LDCM0623  AC156 HCT 116 C522(0.97); C422(1.08); C328(0.88); C392(1.35)  LDD2160  [13]
 LDCM0624  AC157 HCT 116 C522(0.85); C422(1.01); C328(0.84); C392(1.24)  LDD2161  [13]
 LDCM0276  AC17 HCT 116 C487(0.88); C569(0.91); C397(0.97); C522(1.13)  LDD0593  [13]
 LDCM0277  AC18 HCT 116 C397(0.73); C569(0.94); C328(1.05); C487(1.23)  LDD0594  [13]
 LDCM0278  AC19 HCT 116 C569(0.93); C397(0.95); C328(1.02); C422(1.09)  LDD0595  [13]
 LDCM0279  AC2 HCT 116 C392(0.78); C522(1.06); C397(1.11); C569(1.12)  LDD0596  [13]
 LDCM0280  AC20 HCT 116 C397(0.78); C328(0.90); C569(0.94); C392(1.06)  LDD0597  [13]
 LDCM0281  AC21 HCT 116 C397(0.73); C569(0.90); C328(1.06); C422(1.07)  LDD0598  [13]
 LDCM0282  AC22 HCT 116 C397(0.83); C569(0.88); C328(0.96); C487(0.98)  LDD0599  [13]
 LDCM0283  AC23 HCT 116 C328(0.87); C569(0.92); C397(0.93); C422(1.14)  LDD0600  [13]
 LDCM0284  AC24 HCT 116 C397(0.95); C569(0.97); C422(1.06); C328(1.06)  LDD0601  [13]
 LDCM0285  AC25 HCT 116 C392(0.79); C397(0.84); C569(0.93); C328(1.00)  LDD0602  [13]
 LDCM0286  AC26 HCT 116 C397(0.88); C328(1.00); C569(1.00); C392(1.04)  LDD0603  [13]
 LDCM0287  AC27 HCT 116 C397(0.78); C569(0.98); C328(1.04); C422(1.06)  LDD0604  [13]
 LDCM0288  AC28 HCT 116 C392(0.88); C569(0.99); C328(1.02); C397(1.06)  LDD0605  [13]
 LDCM0289  AC29 HCT 116 C397(0.81); C569(0.93); C328(0.99); C392(1.09)  LDD0606  [13]
 LDCM0290  AC3 HCT 116 C392(0.69); C522(0.95); C569(1.08); C397(1.08)  LDD0607  [13]
 LDCM0291  AC30 HCT 116 C392(0.86); C328(0.87); C569(0.87); C397(0.88)  LDD0608  [13]
 LDCM0292  AC31 HCT 116 C392(0.86); C569(0.91); C397(0.97); C328(1.09)  LDD0609  [13]
 LDCM0293  AC32 HCT 116 C397(0.67); C392(0.93); C328(0.94); C569(0.95)  LDD0610  [13]
 LDCM0294  AC33 HCT 116 C569(0.77); C397(0.92); C328(0.95); C392(1.09)  LDD0611  [13]
 LDCM0295  AC34 HCT 116 C397(0.77); C328(0.82); C569(0.86); C392(1.10)  LDD0612  [13]
 LDCM0296  AC35 HCT 116 C397(0.86); C422(0.87); C569(0.88); C522(0.90)  LDD0613  [13]
 LDCM0297  AC36 HCT 116 C397(0.85); C422(0.88); C569(0.88); C522(0.89)  LDD0614  [13]
 LDCM0298  AC37 HCT 116 C397(0.86); C522(0.92); C422(0.93); C569(0.98)  LDD0615  [13]
 LDCM0299  AC38 HCT 116 C569(0.95); C392(0.96); C522(0.96); C328(0.96)  LDD0616  [13]
 LDCM0300  AC39 HCT 116 C392(0.91); C522(0.93); C569(0.94); C328(0.95)  LDD0617  [13]
 LDCM0301  AC4 HCT 116 C392(0.72); C522(1.01); C397(1.02); C569(1.05)  LDD0618  [13]
 LDCM0302  AC40 HCT 116 C569(0.99); C422(1.00); C397(1.02); C392(1.07)  LDD0619  [13]
 LDCM0303  AC41 HCT 116 C397(0.87); C569(0.96); C328(0.98); C522(0.99)  LDD0620  [13]
 LDCM0304  AC42 HCT 116 C397(0.96); C569(0.96); C392(0.99); C328(1.00)  LDD0621  [13]
 LDCM0305  AC43 HCT 116 C392(0.94); C397(0.94); C569(0.99); C328(1.00)  LDD0622  [13]
 LDCM0306  AC44 HCT 116 C392(0.86); C522(0.95); C569(1.01); C397(1.02)  LDD0623  [13]
 LDCM0307  AC45 HCT 116 C397(0.99); C522(1.01); C569(1.05); C392(1.07)  LDD0624  [13]
 LDCM0308  AC46 HCT 116 C422(0.98); C397(1.02); C392(1.05); C522(1.07)  LDD0625  [13]
 LDCM0309  AC47 HCT 116 C392(0.96); C422(0.98); C397(1.01); C522(1.02)  LDD0626  [13]
 LDCM0310  AC48 HCT 116 C422(1.06); C397(1.07); C522(1.12); C392(1.15)  LDD0627  [13]
 LDCM0311  AC49 HCT 116 C397(1.12); C328(1.19); C569(1.23); C392(1.32)  LDD0628  [13]
 LDCM0312  AC5 HCT 116 C392(0.73); C397(0.91); C569(1.09); C522(1.21)  LDD0629  [13]
 LDCM0313  AC50 HCT 116 C397(1.09); C569(1.12); C392(1.17); C328(1.19)  LDD0630  [13]
 LDCM0314  AC51 HCT 116 C422(0.93); C522(1.09); C397(1.14); C569(1.24)  LDD0631  [13]
 LDCM0315  AC52 HCT 116 C397(0.98); C422(1.01); C392(1.08); C522(1.08)  LDD0632  [13]
 LDCM0316  AC53 HCT 116 C397(1.02); C422(1.05); C392(1.09); C569(1.11)  LDD0633  [13]
 LDCM0317  AC54 HCT 116 C328(0.91); C397(0.96); C422(1.19); C522(1.22)  LDD0634  [13]
 LDCM0318  AC55 HCT 116 C522(1.01); C569(1.05); C397(1.15); C422(1.19)  LDD0635  [13]
 LDCM0319  AC56 HCT 116 C569(1.13); C328(1.17); C522(1.44); C422(1.46)  LDD0636  [13]
 LDCM0320  AC57 HCT 116 C392(0.81); C522(0.84); C397(0.98); C569(1.01)  LDD0637  [13]
 LDCM0321  AC58 HCT 116 C522(0.84); C569(0.99); C397(1.04); C392(1.05)  LDD0638  [13]
 LDCM0322  AC59 HCT 116 C522(0.87); C392(0.89); C397(1.05); C328(1.07)  LDD0639  [13]
 LDCM0323  AC6 HCT 116 C328(0.93); C569(0.94); C522(0.99); C397(1.00)  LDD0640  [13]
 LDCM0324  AC60 HCT 116 C392(0.84); C522(0.93); C569(0.97); C397(1.09)  LDD0641  [13]
 LDCM0325  AC61 HCT 116 C522(0.76); C392(0.77); C569(0.90); C397(0.96)  LDD0642  [13]
 LDCM0326  AC62 HCT 116 C522(0.86); C392(0.96); C569(1.05); C328(1.09)  LDD0643  [13]
 LDCM0327  AC63 HCT 116 C392(0.93); C569(0.95); C522(0.98); C328(0.99)  LDD0644  [13]
 LDCM0328  AC64 HCT 116 C522(0.91); C392(0.93); C569(1.14); C328(1.16)  LDD0645  [13]
 LDCM0329  AC65 HCT 116 C392(0.71); C522(0.87); C328(1.07); C569(1.08)  LDD0646  [13]
 LDCM0330  AC66 HCT 116 C522(0.81); C392(0.82); C569(1.09); C328(1.12)  LDD0647  [13]
 LDCM0331  AC67 HCT 116 C392(0.77); C328(0.77); C522(0.82); C397(1.13)  LDD0648  [13]
 LDCM0332  AC68 HCT 116 C522(0.93); C328(0.93); C569(1.00); C422(1.01)  LDD0649  [13]
 LDCM0333  AC69 HCT 116 C522(0.94); C328(0.95); C569(0.98); C397(1.03)  LDD0650  [13]
 LDCM0334  AC7 HCT 116 C397(0.84); C328(0.86); C569(1.03); C392(1.05)  LDD0651  [13]
 LDCM0335  AC70 HCT 116 C397(0.88); C522(0.95); C328(0.96); C392(0.97)  LDD0652  [13]
 LDCM0336  AC71 HCT 116 C397(0.88); C522(0.92); C422(0.94); C328(1.02)  LDD0653  [13]
 LDCM0337  AC72 HCT 116 C328(0.99); C422(1.02); C522(1.05); C397(1.07)  LDD0654  [13]
 LDCM0338  AC73 HCT 116 C328(1.06); C522(1.18); C569(1.32); C392(1.41)  LDD0655  [13]
 LDCM0339  AC74 HCT 116 C569(1.19); C328(1.20); C522(1.29); C392(1.30)  LDD0656  [13]
 LDCM0340  AC75 HCT 116 C569(1.23); C522(1.35); C328(1.36); C392(1.39)  LDD0657  [13]
 LDCM0341  AC76 HCT 116 C397(1.12); C522(1.12); C328(1.14); C569(1.17)  LDD0658  [13]
 LDCM0342  AC77 HCT 116 C522(1.05); C569(1.07); C392(1.20); C422(1.21)  LDD0659  [13]
 LDCM0343  AC78 HCT 116 C397(0.84); C422(1.00); C392(1.00); C522(1.00)  LDD0660  [13]
 LDCM0344  AC79 HCT 116 C522(0.95); C328(1.00); C422(1.02); C569(1.08)  LDD0661  [13]
 LDCM0345  AC8 HCT 116 C328(0.77); C397(0.78); C569(0.96); C392(1.00)  LDD0662  [13]
 LDCM0346  AC80 HCT 116 C397(0.89); C422(1.00); C569(1.02); C522(1.04)  LDD0663  [13]
 LDCM0347  AC81 HCT 116 C328(0.84); C422(0.96); C522(1.05); C569(1.14)  LDD0664  [13]
 LDCM0348  AC82 HCT 116 C328(1.05); C397(1.30); C392(1.34); C522(1.39)  LDD0665  [13]
 LDCM0349  AC83 HCT 116 C487(0.77); C328(0.77); C392(0.99); C397(1.04)  LDD0666  [13]
 LDCM0350  AC84 HCT 116 C487(0.76); C328(0.85); C397(0.93); C569(0.95)  LDD0667  [13]
 LDCM0351  AC85 HCT 116 C487(0.81); C397(0.82); C328(0.83); C392(0.88)  LDD0668  [13]
 LDCM0352  AC86 HCT 116 C487(0.76); C392(0.95); C397(0.99); C569(1.04)  LDD0669  [13]
 LDCM0353  AC87 HCT 116 C487(0.75); C328(0.87); C569(0.89); C397(0.91)  LDD0670  [13]
 LDCM0354  AC88 HCT 116 C487(0.72); C328(0.82); C392(0.86); C397(0.92)  LDD0671  [13]
 LDCM0355  AC89 HCT 116 C487(0.77); C397(0.90); C569(0.94); C392(1.08)  LDD0672  [13]
 LDCM0357  AC90 HCT 116 C487(0.80); C569(0.90); C392(0.95); C422(0.98)  LDD0674  [13]
 LDCM0358  AC91 HCT 116 C487(0.65); C328(0.92); C569(0.96); C392(0.97)  LDD0675  [13]
 LDCM0359  AC92 HCT 116 C487(0.74); C328(0.95); C569(1.00); C397(1.02)  LDD0676  [13]
 LDCM0360  AC93 HCT 116 C569(0.77); C328(0.81); C397(0.93); C487(0.95)  LDD0677  [13]
 LDCM0361  AC94 HCT 116 C397(0.72); C328(0.90); C569(0.93); C392(1.01)  LDD0678  [13]
 LDCM0362  AC95 HCT 116 C487(0.67); C328(0.85); C392(0.86); C569(0.88)  LDD0679  [13]
 LDCM0363  AC96 HCT 116 C392(0.85); C397(0.86); C569(0.87); C487(1.05)  LDD0680  [13]
 LDCM0364  AC97 HCT 116 C487(0.66); C328(0.78); C392(0.83); C397(0.85)  LDD0681  [13]
 LDCM0365  AC98 HCT 116 C392(0.72); C569(0.81); C328(0.93); C397(0.94)  LDD0682  [13]
 LDCM0366  AC99 HCT 116 C392(0.70); C569(0.77); C397(0.92); C328(0.92)  LDD0683  [13]
 LDCM0545  Acetamide MDA-MB-231 C522(0.22)  LDD2138  [9]
 LDCM0248  AKOS034007472 HCT 116 C522(0.95); C422(1.17); C328(0.96); C392(0.90)  LDD0565  [13]
 LDCM0356  AKOS034007680 HCT 116 C392(0.76); C328(0.90); C569(0.98); C397(1.01)  LDD0673  [13]
 LDCM0275  AKOS034007705 HCT 116 C328(0.95); C392(1.03); C397(1.03); C569(1.09)  LDD0592  [13]
 LDCM0156  Aniline NCI-H1299 C522(0.00); C422(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C422(1.10); C522(1.03); C392(0.98)  LDD0078  [13]
 LDCM0498  BS-3668 MDA-MB-231 C522(0.51)  LDD2091  [9]
 LDCM0108  Chloroacetamide HeLa C422(0.00); H73(0.00); H129(0.00); H343(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C397(4.72)  LDD2227  [27]
 LDCM0367  CL1 HCT 116 C392(0.97); C328(0.97); C569(0.98); C397(1.07)  LDD0684  [13]
 LDCM0368  CL10 HCT 116 C569(0.99); C328(1.05); C397(1.05); C392(1.16)  LDD0685  [13]
 LDCM0369  CL100 HCT 116 C392(0.69); C397(0.95); C328(1.09); C569(1.11)  LDD0686  [13]
 LDCM0370  CL101 HCT 116 C569(0.88); C397(0.88); C328(0.89); C422(1.22)  LDD0687  [13]
 LDCM0371  CL102 HCT 116 C397(0.89); C569(0.95); C328(1.01); C422(1.13)  LDD0688  [13]
 LDCM0372  CL103 HCT 116 C569(0.93); C397(0.95); C328(0.96); C422(0.99)  LDD0689  [13]
 LDCM0373  CL104 HCT 116 C328(0.90); C397(0.93); C569(0.95); C392(1.00)  LDD0690  [13]
 LDCM0374  CL105 HCT 116 C397(0.87); C328(0.91); C569(0.95); C487(1.05)  LDD0691  [13]
 LDCM0375  CL106 HCT 116 C397(0.85); C392(0.89); C569(1.02); C487(1.13)  LDD0692  [13]
 LDCM0376  CL107 HCT 116 C397(0.79); C392(0.99); C487(1.00); C569(1.01)  LDD0693  [13]
 LDCM0377  CL108 HCT 116 C392(0.98); C397(0.98); C487(0.98); C569(1.13)  LDD0694  [13]
 LDCM0378  CL109 HCT 116 C397(0.75); C569(0.84); C328(1.02); C392(1.03)  LDD0695  [13]
 LDCM0379  CL11 HCT 116 C392(0.95); C328(1.06); C569(1.07); C397(1.18)  LDD0696  [13]
 LDCM0380  CL110 HCT 116 C397(0.85); C569(0.88); C487(1.06); C392(1.06)  LDD0697  [13]
 LDCM0381  CL111 HCT 116 C397(0.79); C569(0.91); C328(0.99); C487(1.02)  LDD0698  [13]
 LDCM0382  CL112 HCT 116 C397(0.70); C328(0.90); C392(0.90); C569(1.02)  LDD0699  [13]
 LDCM0383  CL113 HCT 116 C569(0.83); C397(0.83); C328(0.90); C392(0.95)  LDD0700  [13]
 LDCM0384  CL114 HCT 116 C569(0.78); C328(0.81); C397(0.86); C392(1.01)  LDD0701  [13]
 LDCM0385  CL115 HCT 116 C397(0.73); C569(0.83); C328(0.88); C392(0.90)  LDD0702  [13]
 LDCM0386  CL116 HCT 116 C392(0.86); C328(0.93); C569(0.93); C522(1.10)  LDD0703  [13]
 LDCM0387  CL117 HCT 116 C328(0.96); C392(0.98); C569(1.13); C397(1.31)  LDD0704  [13]
 LDCM0388  CL118 HCT 116 C397(0.95); C569(0.96); C328(1.00); C422(1.02)  LDD0705  [13]
 LDCM0389  CL119 HCT 116 C397(0.83); C569(0.95); C422(1.01); C392(1.06)  LDD0706  [13]
 LDCM0390  CL12 HCT 116 C569(1.06); C422(1.19); C392(1.21); C328(1.26)  LDD0707  [13]
 LDCM0391  CL120 HCT 116 C397(0.86); C392(0.87); C522(1.00); C569(1.03)  LDD0708  [13]
 LDCM0392  CL121 HCT 116 C392(0.71); C397(0.96); C422(1.05); C522(1.16)  LDD0709  [13]
 LDCM0393  CL122 HCT 116 C397(1.02); C328(1.14); C422(1.22); C569(1.23)  LDD0710  [13]
 LDCM0394  CL123 HCT 116 C397(0.99); C392(1.12); C569(1.25); C422(1.37)  LDD0711  [13]
 LDCM0395  CL124 HCT 116 C392(1.07); C397(1.07); C422(1.13); C328(1.25)  LDD0712  [13]
 LDCM0396  CL125 HCT 116 C392(0.73); C397(0.90); C522(0.98); C422(0.99)  LDD0713  [13]
 LDCM0397  CL126 HCT 116 C328(0.86); C397(0.89); C569(0.91); C522(0.95)  LDD0714  [13]
 LDCM0398  CL127 HCT 116 C522(0.72); C392(0.82); C328(0.88); C422(0.94)  LDD0715  [13]
 LDCM0399  CL128 HCT 116 C522(0.75); C392(0.97); C328(1.05); C569(1.09)  LDD0716  [13]
 LDCM0400  CL13 HCT 116 C397(1.00); C569(1.01); C328(1.06); C392(1.10)  LDD0717  [13]
 LDCM0401  CL14 HCT 116 C569(0.95); C392(1.16); C328(1.17); C397(1.17)  LDD0718  [13]
 LDCM0402  CL15 HCT 116 C397(0.95); C569(0.96); C422(1.12); C328(1.20)  LDD0719  [13]
 LDCM0403  CL16 HCT 116 C569(0.74); C397(0.84); C328(0.87); C392(0.92)  LDD0720  [13]
 LDCM0404  CL17 HCT 116 C397(0.82); C392(0.87); C328(0.94); C569(0.99)  LDD0721  [13]
 LDCM0405  CL18 HCT 116 C397(0.77); C569(0.88); C522(0.91); C392(0.96)  LDD0722  [13]
 LDCM0406  CL19 HCT 116 C397(0.85); C522(0.86); C569(0.91); C392(1.08)  LDD0723  [13]
 LDCM0407  CL2 HCT 116 C328(0.89); C392(0.95); C397(1.02); C522(1.03)  LDD0724  [13]
 LDCM0408  CL20 HCT 116 C569(0.77); C392(0.84); C522(0.95); C397(0.99)  LDD0725  [13]
 LDCM0409  CL21 HCT 116 C392(0.88); C569(0.94); C397(1.05); C328(1.11)  LDD0726  [13]
 LDCM0410  CL22 HCT 116 C328(1.00); C392(1.07); C569(1.09); C522(1.25)  LDD0727  [13]
 LDCM0411  CL23 HCT 116 C397(0.88); C328(0.91); C569(0.91); C522(0.99)  LDD0728  [13]
 LDCM0412  CL24 HCT 116 C392(0.82); C569(0.86); C397(1.01); C522(1.11)  LDD0729  [13]
 LDCM0413  CL25 HCT 116 C522(2.14); C422(1.30); C328(1.04); C392(0.80)  LDD0730  [13]
 LDCM0414  CL26 HCT 116 C522(1.12); C422(1.23); C328(0.94); C392(0.86)  LDD0731  [13]
 LDCM0415  CL27 HCT 116 C522(0.93); C422(1.22); C328(1.22); C392(0.82)  LDD0732  [13]
 LDCM0416  CL28 HCT 116 C522(1.25); C422(1.30); C328(1.22); C392(0.83)  LDD0733  [13]
 LDCM0417  CL29 HCT 116 C522(0.99); C422(1.37); C328(1.31); C392(0.91)  LDD0734  [13]
 LDCM0418  CL3 HCT 116 C522(1.11); C422(1.01); C328(1.08); C392(1.11)  LDD0735  [13]
 LDCM0419  CL30 HCT 116 C522(0.92); C422(1.08); C328(1.16); C392(0.98)  LDD0736  [13]
 LDCM0420  CL31 HCT 116 C522(1.61); C422(1.26); C328(0.95); C392(0.98)  LDD0737  [13]
 LDCM0421  CL32 HCT 116 C522(1.17); C422(1.30); C328(0.94); C392(0.97)  LDD0738  [13]
 LDCM0422  CL33 HCT 116 C522(3.29); C422(1.56); C328(0.98); C392(1.25)  LDD0739  [13]
 LDCM0423  CL34 HCT 116 C522(1.54); C422(1.36); C328(0.94); C392(1.23)  LDD0740  [13]
 LDCM0424  CL35 HCT 116 C522(1.13); C422(1.15); C328(0.99); C392(1.63)  LDD0741  [13]
 LDCM0425  CL36 HCT 116 C522(1.44); C422(1.20); C328(1.07); C392(1.47)  LDD0742  [13]
 LDCM0426  CL37 HCT 116 C522(1.71); C422(1.35); C328(1.19); C392(1.53)  LDD0743  [13]
 LDCM0428  CL39 HCT 116 C522(1.85); C422(1.56); C328(0.99); C392(1.20)  LDD0745  [13]
 LDCM0429  CL4 HCT 116 C522(2.69); C422(0.95); C328(0.87); C392(1.03)  LDD0746  [13]
 LDCM0430  CL40 HCT 116 C522(2.00); C422(1.53); C328(0.94); C392(1.09)  LDD0747  [13]
 LDCM0431  CL41 HCT 116 C522(1.42); C422(1.36); C328(1.08); C392(1.27)  LDD0748  [13]
 LDCM0432  CL42 HCT 116 C522(2.11); C422(1.55); C328(0.94); C392(1.64)  LDD0749  [13]
 LDCM0433  CL43 HCT 116 C522(1.22); C422(1.42); C328(1.12); C392(1.79)  LDD0750  [13]
 LDCM0434  CL44 HCT 116 C522(1.48); C422(1.61); C328(1.04); C392(1.25)  LDD0751  [13]
 LDCM0435  CL45 HCT 116 C522(1.67); C422(1.54); C328(0.98); C392(1.34)  LDD0752  [13]
 LDCM0436  CL46 HCT 116 C522(1.63); C422(1.06); C328(1.14); C392(1.23)  LDD0753  [13]
 LDCM0437  CL47 HCT 116 C522(1.12); C422(0.93); C328(1.03); C392(1.08)  LDD0754  [13]
 LDCM0438  CL48 HCT 116 C522(1.08); C422(0.93); C328(1.17); C392(1.11)  LDD0755  [13]
 LDCM0439  CL49 HCT 116 C522(1.24); C422(0.91); C328(1.19); C392(1.15)  LDD0756  [13]
 LDCM0440  CL5 HCT 116 C522(0.95); C422(1.01); C328(1.35); C392(1.00)  LDD0757  [13]
 LDCM0441  CL50 HCT 116 C522(1.83); C422(0.83); C328(1.21); C392(1.14)  LDD0758  [13]
 LDCM0442  CL51 HCT 116 C522(1.42); C422(0.83); C328(1.26); C392(0.96)  LDD0759  [13]
 LDCM0443  CL52 HCT 116 C522(1.49); C422(0.88); C328(1.30); C392(0.91)  LDD0760  [13]
 LDCM0444  CL53 HCT 116 C522(1.23); C422(0.81); C328(1.16); C392(1.21)  LDD0761  [13]
 LDCM0445  CL54 HCT 116 C522(1.26); C422(0.85); C328(1.16); C392(1.32)  LDD0762  [13]
 LDCM0446  CL55 HCT 116 C522(0.97); C422(0.84); C328(1.30); C392(1.04)  LDD0763  [13]
 LDCM0447  CL56 HCT 116 C522(1.15); C422(1.02); C328(1.00); C392(1.39)  LDD0764  [13]
 LDCM0448  CL57 HCT 116 C522(1.69); C422(1.08); C328(1.15); C392(1.18)  LDD0765  [13]
 LDCM0449  CL58 HCT 116 C522(1.53); C422(0.89); C328(1.06); C392(1.26)  LDD0766  [13]
 LDCM0450  CL59 HCT 116 C522(0.96); C422(0.93); C328(1.13); C392(1.15)  LDD0767  [13]
 LDCM0451  CL6 HCT 116 C522(1.60); C422(1.11); C328(1.11); C392(1.01)  LDD0768  [13]
 LDCM0452  CL60 HCT 116 C522(1.30); C422(0.94); C328(1.00); C392(1.13)  LDD0769  [13]
 LDCM0453  CL61 HCT 116 C522(1.24); C422(0.91); C328(1.19); C392(1.14)  LDD0770  [13]
 LDCM0454  CL62 HCT 116 C522(1.24); C422(0.92); C328(0.99); C392(0.97)  LDD0771  [13]
 LDCM0455  CL63 HCT 116 C522(1.40); C422(1.24); C328(0.88); C392(1.14)  LDD0772  [13]
 LDCM0456  CL64 HCT 116 C522(1.73); C422(1.16); C328(0.98); C392(0.93)  LDD0773  [13]
 LDCM0457  CL65 HCT 116 C522(1.14); C422(0.97); C328(0.99); C392(0.97)  LDD0774  [13]
 LDCM0458  CL66 HCT 116 C522(1.81); C422(1.39); C328(0.99); C392(1.12)  LDD0775  [13]
 LDCM0459  CL67 HCT 116 C522(1.23); C422(1.09); C328(0.87); C392(1.23)  LDD0776  [13]
 LDCM0460  CL68 HCT 116 C522(1.26); C422(1.03); C328(0.81); C392(1.13)  LDD0777  [13]
 LDCM0461  CL69 HCT 116 C522(1.56); C422(1.19); C328(0.98); C392(0.88)  LDD0778  [13]
 LDCM0462  CL7 HCT 116 C522(1.33); C422(1.22); C328(1.22); C392(1.01)  LDD0779  [13]
 LDCM0463  CL70 HCT 116 C522(1.31); C422(1.19); C328(0.95); C392(0.92)  LDD0780  [13]
 LDCM0464  CL71 HCT 116 C522(1.77); C422(1.04); C328(0.75); C392(0.93)  LDD0781  [13]
 LDCM0465  CL72 HCT 116 C522(1.20); C422(0.99); C328(0.84); C392(1.32)  LDD0782  [13]
 LDCM0466  CL73 HCT 116 C522(1.59); C422(1.00); C328(0.84); C392(0.99)  LDD0783  [13]
 LDCM0467  CL74 HCT 116 C522(1.41); C422(1.03); C328(0.87); C392(0.94)  LDD0784  [13]
 LDCM0469  CL76 HCT 116 C522(1.04); C422(1.00); C328(1.11); C392(0.93)  LDD0786  [13]
 LDCM0470  CL77 HCT 116 C522(2.97); C422(0.89); C328(1.01); C392(1.21)  LDD0787  [13]
 LDCM0471  CL78 HCT 116 C522(1.29); C422(0.96); C328(1.02); C392(0.96)  LDD0788  [13]
 LDCM0472  CL79 HCT 116 C522(1.14); C422(1.16); C328(1.11); C392(1.04)  LDD0789  [13]
 LDCM0473  CL8 HCT 116 C522(11.26); C422(4.11); C328(1.02); C392(1.04)  LDD0790  [13]
 LDCM0474  CL80 HCT 116 C522(1.05); C422(0.92); C328(1.16); C392(1.17)  LDD0791  [13]
 LDCM0475  CL81 HCT 116 C522(1.30); C422(0.96); C328(1.09); C392(1.05)  LDD0792  [13]
 LDCM0476  CL82 HCT 116 C522(1.34); C422(1.21); C328(1.25); C392(1.07)  LDD0793  [13]
 LDCM0477  CL83 HCT 116 C522(1.61); C422(1.18); C328(1.07); C392(0.98)  LDD0794  [13]
 LDCM0478  CL84 HCT 116 C522(3.31); C422(1.43); C328(1.23); C392(1.03)  LDD0795  [13]
 LDCM0479  CL85 HCT 116 C522(1.18); C422(1.22); C328(1.19); C392(1.15)  LDD0796  [13]
 LDCM0480  CL86 HCT 116 C522(2.12); C422(1.09); C328(0.97); C392(1.14)  LDD0797  [13]
 LDCM0481  CL87 HCT 116 C522(1.52); C422(1.16); C328(1.11); C392(1.44)  LDD0798  [13]
 LDCM0482  CL88 HCT 116 C522(1.26); C422(1.23); C328(1.18); C392(1.29)  LDD0799  [13]
 LDCM0483  CL89 HCT 116 C522(1.78); C422(1.75); C328(1.18); C392(1.17)  LDD0800  [13]
 LDCM0484  CL9 HCT 116 C522(1.28); C422(1.08); C328(0.99); C392(0.98)  LDD0801  [13]
 LDCM0485  CL90 HCT 116 C522(4.95); C422(1.34); C328(1.09); C392(1.07)  LDD0802  [13]
 LDCM0486  CL91 HCT 116 C522(1.25); C422(1.15); C328(0.94); C392(0.66)  LDD0803  [13]
 LDCM0487  CL92 HCT 116 C522(1.69); C422(1.26); C328(1.00); C392(0.70)  LDD0804  [13]
 LDCM0488  CL93 HCT 116 C522(1.27); C422(1.13); C328(1.22); C392(0.80)  LDD0805  [13]
 LDCM0489  CL94 HCT 116 C522(1.87); C422(1.07); C328(1.19); C392(0.64)  LDD0806  [13]
 LDCM0490  CL95 HCT 116 C522(2.38); C422(1.37); C328(1.04); C392(0.57)  LDD0807  [13]
 LDCM0491  CL96 HCT 116 C522(1.55); C422(1.20); C328(1.20); C392(0.65)  LDD0808  [13]
 LDCM0492  CL97 HCT 116 C522(2.73); C422(1.29); C328(1.10); C392(0.73)  LDD0809  [13]
 LDCM0493  CL98 HCT 116 C522(1.52); C422(1.51); C328(0.98); C392(0.64)  LDD0810  [13]
 LDCM0494  CL99 HCT 116 C522(1.29); C422(1.71); C328(1.17); C392(0.75)  LDD0811  [13]
 LDCM0634  CY-0357 Hep-G2 C422(0.21)  LDD2228  [27]
 LDCM0495  E2913 HEK-293T C397(1.04); C522(1.22); C422(0.98); C328(1.10)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C522(10.21); C569(4.05); C328(2.58); C392(1.61)  LDD1702  [9]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [11]
 LDCM0625  F8 Ramos C328(0.85); C422(1.29); C397(1.12); C392(0.70)  LDD2187  [37]
 LDCM0572  Fragment10 Ramos C522(3.65)  LDD1390  [38]
 LDCM0573  Fragment11 MDA-MB-231 C522(20.00)  LDD1391  [38]
 LDCM0574  Fragment12 MDA-MB-231 C522(20.00)  LDD1393  [38]
 LDCM0575  Fragment13 MDA-MB-231 C522(9.23)  LDD1395  [38]
 LDCM0576  Fragment14 MDA-MB-231 C522(20.00)  LDD1397  [38]
 LDCM0579  Fragment20 MDA-MB-231 C522(1.61)  LDD1402  [38]
 LDCM0580  Fragment21 MDA-MB-231 C522(1.70)  LDD1404  [38]
 LDCM0581  Fragment22 Ramos C522(3.36)  LDD1407  [38]
 LDCM0582  Fragment23 Ramos C522(1.71)  LDD1409  [38]
 LDCM0578  Fragment27 MDA-MB-231 C522(0.96)  LDD1401  [38]
 LDCM0586  Fragment28 MDA-MB-231 C522(1.34)  LDD1415  [38]
 LDCM0587  Fragment29 Ramos C522(0.71)  LDD1418  [38]
 LDCM0588  Fragment30 MDA-MB-231 C522(1.65)  LDD1419  [38]
 LDCM0589  Fragment31 Ramos C522(3.58)  LDD1478  [38]
 LDCM0590  Fragment32 Ramos C522(20.00)  LDD1424  [38]
 LDCM0468  Fragment33 HCT 116 C522(1.25); C422(1.19); C328(0.91); C392(0.98)  LDD0785  [13]
 LDCM0595  Fragment37 Ramos C522(1.20)  LDD1432  [38]
 LDCM0596  Fragment38 MDA-MB-231 C522(1.09)  LDD1433  [38]
 LDCM0566  Fragment4 MDA-MB-231 C522(2.69)  LDD1378  [38]
 LDCM0599  Fragment41 MDA-MB-231 C522(1.52)  LDD1438  [38]
 LDCM0600  Fragment42 Ramos C522(0.57)  LDD1440  [38]
 LDCM0601  Fragment43 Ramos C522(6.94)  LDD1442  [38]
 LDCM0603  Fragment45 MDA-MB-231 C522(20.00)  LDD1482  [38]
 LDCM0604  Fragment46 MDA-MB-231 C522(1.08)  LDD1445  [38]
 LDCM0605  Fragment47 MDA-MB-231 C522(1.41)  LDD1446  [38]
 LDCM0608  Fragment50 MDA-MB-231 C522(20.00)  LDD1449  [38]
 LDCM0427  Fragment51 HCT 116 C522(1.76); C422(2.21); C328(1.06); C392(1.87)  LDD0744  [13]
 LDCM0610  Fragment52 Ramos C328(0.99); C422(1.38); C397(0.81); C392(0.82)  LDD2204  [37]
 LDCM0611  Fragment53 MDA-MB-231 C522(1.04)  LDD1454  [38]
 LDCM0612  Fragment54 MDA-MB-231 C522(1.78)  LDD1456  [38]
 LDCM0614  Fragment56 MDA-MB-231 C522(1.13)  LDD1458  [38]
 LDCM0568  Fragment6 MDA-MB-231 C522(1.16)  LDD1382  [38]
 LDCM0569  Fragment7 Ramos C328(1.63); C422(1.60); C397(1.76); C392(1.31)  LDD2186  [37]
 LDCM0570  Fragment8 Ramos C522(4.30)  LDD1386  [38]
 LDCM0571  Fragment9 MDA-MB-231 C522(2.10)  LDD1387  [38]
 LDCM0116  HHS-0101 DM93 Y386(0.16); Y166(0.74)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y386(0.12); Y166(1.08)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y386(0.15); Y166(1.53)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y386(0.19); Y166(1.01)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y386(0.14); Y166(0.91)  LDD0268  [12]
 LDCM0107  IAA HeLa C422(0.00); H73(0.00); H343(0.00)  LDD0221  [25]
 LDCM0022  KB02 HCT 116 C522(20.00); C397(2.25); C422(1.64)  LDD0080  [13]
 LDCM0023  KB03 HCT 116 C522(5.53); C397(1.29); C422(2.27)  LDD0081  [13]
 LDCM0024  KB05 HCT 116 C522(4.98); C397(1.42); C422(1.35)  LDD0082  [13]
 LDCM0169  KB63 Ramos 6.50  LDD0432  [39]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C522(0.96)  LDD2102  [9]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C522(0.56)  LDD2121  [9]
 LDCM0109  NEM HeLa H146(0.00); H73(0.00); H129(0.00); H343(0.00)  LDD0223  [25]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C522(0.98)  LDD2090  [9]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C522(0.70)  LDD2092  [9]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C522(0.89)  LDD2093  [9]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C522(0.99)  LDD2094  [9]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C522(1.36)  LDD2096  [9]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C522(0.79)  LDD2098  [9]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C522(0.77)  LDD2099  [9]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C522(1.06)  LDD2105  [9]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C522(0.85)  LDD2106  [9]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C522(0.99); C392(0.91)  LDD2107  [9]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C522(0.84)  LDD2108  [9]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C522(0.91)  LDD2109  [9]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C522(2.37)  LDD2110  [9]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C522(0.92)  LDD2111  [9]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C522(1.10)  LDD2114  [9]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C522(0.41)  LDD2116  [9]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C522(1.50)  LDD2119  [9]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C522(0.56)  LDD2122  [9]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C392(0.64)  LDD2123  [9]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C522(2.40)  LDD2124  [9]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C392(0.95)  LDD2125  [9]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C522(0.91)  LDD2127  [9]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C522(0.70)  LDD2129  [9]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C522(0.82)  LDD2135  [9]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C522(1.07)  LDD2136  [9]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C522(0.83)  LDD2137  [9]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C522(0.87)  LDD2140  [9]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C392(0.62)  LDD2143  [9]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C522(2.09)  LDD2144  [9]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C522(1.06)  LDD2146  [9]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C522(0.52)  LDD2150  [9]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C522(1.40)  LDD2153  [9]
 LDCM0627  NUDT7-COV-1 HEK-293T C422(1.27); C422(0.98); C569(0.73)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C522(1.17); C397(1.01); C569(0.93); C422(0.52)  LDD2207  [40]
 LDCM0131  RA190 MM1.R C522(1.32); C422(1.08)  LDD0304  [41]
 LDCM0019  Staurosporine Hep-G2 N.A.  LDD0083  [33]
 LDCM0021  THZ1 HCT 116 C522(0.98); C392(1.01)  LDD2173  [13]
 LDCM0111  W14 Hep-G2 C422(15.40)  LDD0238  [5]
 LDCM0112  W16 Hep-G2 C522(1.44)  LDD0239  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metallophosphoesterase MPPED2 (MPPED2) UPF0046 family Q15777
85/88 kDa calcium-independent phospholipase A2 (PLA2G6) . O60733
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Transmembrane protein 100 (TMEM100) . Q9NV29
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Opioid-binding protein/cell adhesion molecule (OPCML) IgLON family Q14982
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-5 complex subunit zeta-1 (AP5Z1) . O43299

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
7 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
8 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
9 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
14 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
15 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
16 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
17 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
18 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
19 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
20 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
24 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
28 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
29 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
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Mass spectrometry data entry: PXD007570
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Mass spectrometry data entry: PXD027578
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