Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment10  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 59 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 20.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 17.6
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 5.6
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 4.9
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 4.3
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 3.4
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 3.2
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 2.6
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 1.9
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.7
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.6
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.6
 LDTP11931  SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A containing DEAD/H box 1 (SMARCAD1) C772 1.6
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.6
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.6
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 1.5
 LDTP06211  Caspase-8 (CASP8) C360 1.5
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.5
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.4
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 1.4
 LDTP04689  Adenosine kinase (ADK) C353 1.4
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.4
 LDTP02502  Thioredoxin (TXN) C32 1.4
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 1.4
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.3
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.3
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.3
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.3
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.1
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.1
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.1
 LDTP02672  Elongation factor 2 (EEF2) C41 1.0
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 0.9
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 0.9
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 0.9
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.8
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 0.8
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 0.8
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.8
 LDTP03400  Deoxycytidine kinase (DCK) C45 0.7
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 0.7
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 0.7
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.6
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 0.6
 LDTP02672  Elongation factor 2 (EEF2) C136 0.6
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 0.5
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 0.4
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.4
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 7.2
 LDTP11855  Pinin (PNN) C249 4.5
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 4.1
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 3.7
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.7
 LDTP04662  Exportin-2 (CSE1L) C842 1.4
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.1
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.1
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 0.9
 LDTP13661  Sorting nexin-6 (SNX6) C264 0.9
 LDTP00501  Exportin-1 (XPO1) C34 0.7
 LDTP01574  Importin-7 (IPO7) C757 0.6
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.6
Transcription factor
Click to Show/Hide to Show 2 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 8.5
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 0.6
Other
Click to Show/Hide to Show 57 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP07755  Dynamin-binding protein (DNMBP) C691 20.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 18.8
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 6.4
 LDTP12412  Reticulon-4 (RTN4) C1101 4.3
 LDTP04902  Actin-related protein 3 (ACTR3) C235 3.2
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 3.1
 LDTP04092  Crk-like protein (CRKL) C249 2.4
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 2.3
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 2.1
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 2.0
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.7
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.7
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.7
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.7
 LDTP10864  Calponin-2 (CNN2) C215 1.6
 LDTP13580  Coronin-1C (CORO1C) C420 1.6
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.5
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.5
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.4
 LDTP10864  Calponin-2 (CNN2) C164 1.4
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 1.4
 LDTP05259  Heterogeneous nuclear ribonucleoprotein U (HNRNPU) C562 1.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.3
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.2
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.2
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.2
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.1
 LDTP02205  Tubulin beta chain (TUBB) C354 1.1
 LDTP11212  Tubulin-specific chaperone D (TBCD) C850 1.1
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.1
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.0
 LDTP01532  ZW10 interactor (ZWINT) C54 1.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.0
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.0
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 1.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.0
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 1.0
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.0
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) C1117 0.9
 LDTP09549  Conserved oligomeric Golgi complex subunit 1 (COG1) C513 0.9
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.9
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 0.9
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C1174 0.9
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.8
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.8
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 0.8
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 0.8
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.7
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 0.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.7
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 0.7
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 0.6
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 0.5
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 0.4

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.