Details of the Target

General Information of Target

Target ID LDTP00431
Target Name Kinetochore protein NDC80 homolog (NDC80)
Gene Name NDC80
Gene ID 10403
Synonyms
HEC; HEC1; KNTC2; Kinetochore protein NDC80 homolog; Highly expressed in cancer protein; Kinetochore protein Hec1; HsHec1; Kinetochore-associated protein 2; Retinoblastoma-associated protein HEC
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKRSSVSSGGAGRLSMQELRSQDVNKQGLYTPQTKEKPTFGKLSINKPTSERKVSLFGKR
TSGHGSRNSQLGIFSSSEKIKDPRPLNDKAFIQQCIRQLCEFLTENGYAHNVSMKSLQAP
SVKDFLKIFTFLYGFLCPSYELPDTKFEEEVPRIFKDLGYPFALSKSSMYTVGAPHTWPH
IVAALVWLIDCIKIHTAMKESSPLFDDGQPWGEETEDGIMHNKLFLDYTIKCYESFMSGA
DSFDEMNAELQSKLKDLFNVDAFKLESLEAKNRALNEQIARLEQEREKEPNRLESLRKLK
ASLQGDVQKYQAYMSNLESHSAILDQKLNGLNEEIARVELECETIKQENTRLQNIIDNQK
YSVADIERINHERNELQQTINKLTKDLEAEQQKLWNEELKYARGKEAIETQLAEYHKLAR
KLKLIPKGAENSKGYDFEIKFNPEAGANCLVKYRAQVYVPLKELLNETEEEINKALNKKM
GLEDTLEQLNAMITESKRSVRTLKEEVQKLDDLYQQKIKEAEEEDEKCASELESLEKHKH
LLESTVNQGLSEAMNELDAVQREYQLVVQTTTEERRKVGNNLQRLLEMVATHVGSVEKHL
EEQIAKVDREYEECMSEDLSENIKEIRDKYEKKATLIKSSEE
Target Bioclass
Other
Family
NDC80/HEC1 family
Subcellular location
Nucleus
Function
Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity . Required for kinetochore integrity and the organization of stable microtubule binding sites in the outer plate of the kinetochore. The NDC80 complex synergistically enhances the affinity of the SKA1 complex for microtubules and may allow the NDC80 complex to track depolymerizing microtubules. Plays a role in chromosome congression and is essential for the end-on attachment of the kinetochores to spindle microtubules.
Uniprot ID
O14777
Ensemble ID
ENST00000261597.9
HGNC ID
HGNC:16909
ChEMBL ID
CHEMBL5660

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 24 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CY-1
 Probe Info  		100.00  LDD0243  [2]
N1
 Probe Info  		100.00  LDD0242  [2]
STPyne
 Probe Info  		K255(1.67); K271(0.57); K382(6.79); K53(5.97)  LDD0277  [3]
BTD
 Probe Info  		C342(1.19); C449(0.96)  LDD2099  [4]
NAIA_5
 Probe Info  		C528(20.00); C449(0.33)  LDD2227  [5]
Alkyne-RA190
 Probe Info  		2.10  LDD0299  [6]
HHS-475
 Probe Info  		Y310(3.48)  LDD0266  [7]
DBIA
 Probe Info  		C528(1.39)  LDD0080  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [9]
IA-alkyne
 Probe Info  		C95(0.00); C137(0.00)  LDD0036  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C95(0.00); C449(0.00); C137(0.00); C342(0.00)  LDD0037  [9]
NAIA_4
 Probe Info  		N.A.  LDD2226  [5]
ENE
 Probe Info  		N.A.  LDD0006  [11]
IPM
 Probe Info  		N.A.  LDD0005  [11]
PF-06672131
 Probe Info  		N.A.  LDD0017  [12]
SF
 Probe Info  		N.A.  LDD0028  [13]
TFBX
 Probe Info  		C95(0.00); C449(0.00)  LDD0148  [14]
VSF
 Probe Info  		N.A.  LDD0007  [11]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
Acrolein
 Probe Info  		N.A.  LDD0217  [16]
W1
 Probe Info  		N.A.  LDD0236  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C087
 Probe Info  		6.92  LDD1779  [19]
C284
 Probe Info  		23.43  LDD1954  [19]
VE-P
 Probe Info  		N.A.  LDD0396  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0214  AC1 HCT 116 C232(0.98); C449(1.11); C95(0.89)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C232(0.83); C449(0.79)  LDD0532  [8]
 LDCM0216  AC100 PaTu 8988t C449(1.38); C528(1.29); C95(0.70); C232(0.84)  LDD1095  [8]
 LDCM0217  AC101 PaTu 8988t C449(1.21); C528(1.03); C95(1.03); C232(0.96)  LDD1096  [8]
 LDCM0218  AC102 PaTu 8988t C449(1.16); C528(1.22); C95(0.92); C232(0.96)  LDD1097  [8]
 LDCM0219  AC103 PaTu 8988t C449(1.44); C528(1.33); C95(0.89); C232(0.96)  LDD1098  [8]
 LDCM0220  AC104 PaTu 8988t C449(1.23); C528(1.40); C95(0.85); C232(1.01)  LDD1099  [8]
 LDCM0221  AC105 PaTu 8988t C449(1.21); C528(1.91); C95(0.83); C232(1.03)  LDD1100  [8]
 LDCM0222  AC106 PaTu 8988t C449(1.50); C528(1.41); C95(0.85); C232(1.01)  LDD1101  [8]
 LDCM0223  AC107 PaTu 8988t C449(1.24); C528(1.09); C95(0.88); C232(1.04)  LDD1102  [8]
 LDCM0224  AC108 PaTu 8988t C449(1.45); C528(1.10); C95(0.79); C232(0.83)  LDD1103  [8]
 LDCM0225  AC109 PaTu 8988t C449(1.58); C528(1.48); C95(0.86); C232(1.00)  LDD1104  [8]
 LDCM0226  AC11 HCT 116 C232(0.91); C449(0.65)  LDD0543  [8]
 LDCM0227  AC110 PaTu 8988t C449(1.65); C528(1.33); C95(0.86); C232(0.90)  LDD1106  [8]
 LDCM0228  AC111 PaTu 8988t C449(1.93); C528(1.78); C95(0.91); C232(0.86)  LDD1107  [8]
 LDCM0229  AC112 PaTu 8988t C449(1.41); C528(1.19); C95(0.85); C232(0.80)  LDD1108  [8]
 LDCM0230  AC113 HCT 116 C232(1.15); C449(0.93)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C232(0.94); C449(1.06)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C232(0.85); C449(1.04)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C232(0.93); C449(0.87)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C232(0.87); C449(0.91)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C232(1.01); C449(0.85)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C232(1.06); C449(1.00)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C232(0.86); C449(0.77)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C232(0.84); C449(1.09)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C232(1.07); C449(0.84)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C232(1.02); C449(0.88)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C232(0.87); C449(0.78)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C232(0.98); C449(0.75)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C232(0.84); C449(0.94)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C232(0.91); C449(0.90)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C232(0.89); C449(0.81)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C232(1.28)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C232(1.00)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C232(1.15)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C232(1.03)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C232(1.16)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C232(1.15)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C232(1.28)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C232(1.29)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C232(1.17)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C232(1.13)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C232(1.30)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C232(1.14)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C232(0.88); C449(0.76)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C232(1.34)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C232(1.27)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C232(1.31)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C232(0.87); C95(0.92); C449(1.20)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C232(0.64); C95(0.94); C449(1.05)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C232(0.84); C95(0.92); C449(1.24)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C232(0.59); C95(0.88); C449(1.41)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C232(0.63); C449(0.97); C95(0.98)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C232(1.11); C95(1.11); C449(3.61)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C232(0.78); C95(0.96); C449(2.48)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C232(0.83); C449(0.86)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C232(0.69); C95(1.00); C449(1.22)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C232(0.76); C95(0.86); C449(1.05)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C232(0.84); C95(0.93); C449(0.96)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C232(0.98); C95(1.11); C449(2.29)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C232(0.64); C449(1.04); C95(0.94)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C232(0.77); C449(1.43); C95(0.83)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C232(0.78); C449(1.22); C95(0.91)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C232(0.64); C449(1.13); C95(0.73)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C449(0.87); C232(0.90)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C449(0.75); C232(0.96)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C232(0.83); C449(0.85)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C232(0.84); C95(1.01); C449(1.17)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C232(0.88); C449(1.00)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C449(0.80); C232(0.81)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C449(0.87); C232(1.02)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C449(0.82); C232(0.88)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C232(0.87); C449(0.94)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C232(0.76)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C232(0.82)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C232(0.76)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C232(0.72)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C232(0.79)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C232(0.96); C95(1.02); C449(1.09)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C232(0.76)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C232(0.72)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C232(0.70)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C232(0.67)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C232(0.63)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C95(0.97); C232(1.19)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C232(1.01); C95(1.01)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C232(1.03); C95(1.15)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C232(0.93); C95(1.13)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C232(0.99); C95(1.31)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C232(0.90); C95(0.94); C449(1.40)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C232(1.11); C95(1.13)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C232(0.93); C95(1.03)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C232(1.05); C95(1.11)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C232(1.00); C95(1.01)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C232(1.04); C95(1.32)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C232(1.13); C95(1.13)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C95(1.06); C449(1.71)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C95(1.00); C449(1.08)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C95(1.09); C449(1.22)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C95(1.01); C449(1.61)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C232(0.81); C95(0.94); C449(1.41)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C95(0.98); C449(1.50)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C95(1.09); C449(1.32)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C95(0.88); C449(1.36)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C95(0.99); C449(1.06)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C95(0.74); C449(1.33)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C449(0.86); C95(1.38)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C95(1.22); C449(1.32)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C449(0.92); C95(1.18)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C449(1.00); C95(1.11)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C449(1.23); C95(1.29)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C232(0.72); C449(1.13)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C449(1.18); C95(1.33)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C449(0.95); C95(1.31)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C449(1.06); C95(1.29)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C449(1.09); C95(1.09)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C449(1.09); C95(1.44)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C449(0.96); C95(1.51)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C449(0.99); C95(1.45)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C449(1.11); C95(1.51)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C449(1.10)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C449(0.97)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C232(0.90); C449(1.93)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C449(1.23)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C449(0.91)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C449(1.05)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C449(1.09)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C449(0.95)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C449(1.18)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C449(0.80)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C449(1.08)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C449(0.97)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C449(1.15)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C232(0.98); C449(1.08)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C449(0.77)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C449(1.00)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C449(0.86)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C95(0.94); C449(1.73)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C95(0.99); C449(1.63)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C95(0.79); C449(1.37)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C95(0.89); C449(1.31)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C95(0.94); C449(1.02)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C95(0.98); C449(1.10)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C95(1.04); C449(1.32)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C449(0.83); C95(1.08)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C95(1.02); C449(1.66)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C95(0.88); C449(1.59)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C95(1.00); C449(1.18)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C95(0.97); C449(1.28)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C95(0.89); C449(1.04)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C95(0.96); C449(1.24)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C95(1.02); C449(1.35)  LDD0681  [8]
 LDCM0365  AC98 PaTu 8988t C449(1.28); C528(1.38); C95(0.88); C232(0.86)  LDD1244  [8]
 LDCM0366  AC99 PaTu 8988t C449(1.25); C528(1.08); C95(0.89); C232(0.94)  LDD1245  [8]
 LDCM0248  AKOS034007472 HCT 116 C232(1.00); C449(0.92)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C232(0.83); C449(0.99)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C232(0.78); C449(1.15)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 13.79  LDD0403  [1]
 LDCM0630  CCW28-3 231MFP C449(1.47)  LDD2214  [21]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [16]
 LDCM0632  CL-Sc Hep-G2 C528(20.00); C449(0.33)  LDD2227  [5]
 LDCM0367  CL1 HCT 116 C449(0.98); C232(1.07)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C232(1.01); C449(1.28)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C232(0.79); C95(0.87); C449(1.19)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C232(0.84); C449(1.07)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C449(0.77); C232(0.90)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C449(0.80); C232(0.85)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C232(0.89); C449(1.01)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C232(0.84); C449(0.86)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C449(0.70); C232(0.89)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C449(0.73); C232(0.85)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C449(0.85); C232(0.91)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C232(0.85); C449(0.86)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C232(1.14); C449(1.35)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C232(0.77); C449(1.08)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C232(0.73); C449(1.21)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C232(0.95)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C232(0.72)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C232(0.74)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C232(0.74)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C232(0.77)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C95(1.15); C232(1.51)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C232(1.06); C95(1.10)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C95(1.05); C232(1.07)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C232(1.00); C449(1.48)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C232(0.93); C95(1.05)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C95(1.21); C449(1.27)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C95(1.17); C449(1.39)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C95(1.05); C449(2.50)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C95(0.70); C449(1.40)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C449(1.00); C95(1.01)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C95(0.99); C449(1.06)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C95(1.03); C449(1.05)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C449(0.89); C95(1.28)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C232(0.84); C449(1.23)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C232(0.85); C449(1.08)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C232(0.83); C449(1.08)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C232(0.81); C95(1.03)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C95(0.86); C232(0.93); C449(1.16)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C232(1.05); C449(1.06); C95(1.08)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C232(0.91); C95(0.96); C449(0.99)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C449(0.89); C232(1.14)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C232(0.91); C95(1.14); C449(1.18)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C232(0.99); C95(1.03); C449(1.59)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C449(1.10); C95(1.35); C232(1.49)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C232(0.72); C95(1.04); C449(1.27)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C232(0.84); C449(1.02); C95(1.04)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C232(0.80); C449(1.21); C95(1.07)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C232(0.81); C449(1.08); C95(1.03)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C232(0.73); C449(1.07); C95(1.13)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C232(0.81); C449(1.01); C95(1.05)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C232(0.99); C449(1.11); C95(1.10)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C232(0.83); C449(0.99)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C232(0.92); C449(0.86); C95(1.06)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C232(0.58); C449(1.13)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C232(0.97); C449(1.07)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C232(0.87); C449(1.52)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C232(0.79); C449(1.60)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C232(0.76); C449(1.65)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C232(0.79); C449(1.75)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C232(0.91); C449(1.56)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C232(0.72); C449(1.64)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C232(0.75); C449(1.07)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C232(0.83); C449(1.46)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C232(0.77); C449(1.43)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C232(1.04); C449(1.81)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C232(0.90); C449(1.63)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C232(0.76); C449(1.45)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C232(0.75); C449(1.53)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C232(1.09)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C232(0.96)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C232(1.04)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C232(0.87)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C232(0.85); C449(0.97)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C232(0.83)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C232(1.12)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C232(0.84)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C232(0.90)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C232(0.98)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C232(1.13)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C232(0.81)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C232(1.03)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C232(0.90)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C232(0.95)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C232(0.86); C449(1.10)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C232(0.83)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C232(0.91); C449(0.80)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C232(0.83); C449(0.85)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C232(0.78); C449(1.03)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C232(0.82); C449(0.90)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C232(0.86); C449(0.99)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C232(0.79); C449(0.92)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C232(0.99); C449(0.76)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C232(0.90); C449(0.77)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C232(0.85); C449(1.08)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C232(0.87); C449(1.26)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C232(0.85); C449(1.03)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C232(0.77); C449(0.88)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C232(1.13); C449(0.74)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C232(0.89); C449(0.80)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C232(0.84); C449(0.82)  LDD0784  [8]
 LDCM0469  CL76 PaTu 8988t C528(1.24); C95(1.08); C232(1.12)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C528(1.46); C95(1.17); C232(0.99)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C528(1.31); C95(1.38); C232(1.03)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C528(1.46); C95(1.50); C232(0.96)  LDD1351  [8]
 LDCM0473  CL8 HCT 116 C232(1.04); C449(1.57)  LDD0790  [8]
 LDCM0474  CL80 PaTu 8988t C528(1.74); C95(1.39); C232(1.19)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C528(1.36); C95(1.46); C232(0.96)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C528(1.78); C95(1.45); C232(0.92)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C528(1.65); C95(1.44); C232(1.01)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C528(1.43); C95(1.40); C232(1.10)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C528(1.32); C95(1.04); C232(0.96)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C528(1.59); C95(1.12); C232(1.06)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C528(1.61); C95(1.48); C232(1.22)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C528(1.46); C95(1.64); C232(1.09)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C528(1.87); C95(1.22); C232(1.17)  LDD1362  [8]
 LDCM0484  CL9 HCT 116 C232(0.95); C449(1.24)  LDD0801  [8]
 LDCM0485  CL90 PaTu 8988t C528(1.51); C95(1.25); C232(0.91)  LDD1364  [8]
 LDCM0486  CL91 HCT 116 C232(0.85); C449(1.23); C95(0.95)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C232(0.91); C449(1.85); C95(0.86)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C232(0.91); C449(1.06); C95(0.77)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C232(0.78); C449(1.32); C95(0.83)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C232(0.81); C449(1.37); C95(0.85)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C232(0.79); C449(1.27); C95(0.87)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C232(1.01); C449(1.33); C95(0.88)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C232(0.71); C449(1.43); C95(0.91)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C232(0.78); C449(1.22); C95(0.91)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C528(1.12); C342(0.87); C449(1.02); C137(0.89)  LDD1698  [22]
 LDCM0625  F8 Ramos C449(0.76)  LDD2187  [23]
 LDCM0572  Fragment10 MDA-MB-231 C449(1.95)  LDD1389  [24]
 LDCM0573  Fragment11 MDA-MB-231 C449(1.74)  LDD1391  [24]
 LDCM0575  Fragment13 MDA-MB-231 C449(1.27)  LDD1395  [24]
 LDCM0576  Fragment14 MDA-MB-231 C449(6.31)  LDD1397  [24]
 LDCM0577  Fragment15 Ramos C449(1.95)  LDD1400  [24]
 LDCM0579  Fragment20 MDA-MB-231 C449(2.13)  LDD1402  [24]
 LDCM0580  Fragment21 MDA-MB-231 C449(4.04)  LDD1404  [24]
 LDCM0581  Fragment22 MDA-MB-231 C449(1.11)  LDD1406  [24]
 LDCM0582  Fragment23 MDA-MB-231 C449(2.60)  LDD1408  [24]
 LDCM0584  Fragment25 MDA-MB-231 C449(0.63)  LDD1411  [24]
 LDCM0578  Fragment27 MDA-MB-231 C449(0.88)  LDD1401  [24]
 LDCM0586  Fragment28 MDA-MB-231 C449(0.90)  LDD1415  [24]
 LDCM0587  Fragment29 MDA-MB-231 C449(1.07)  LDD1417  [24]
 LDCM0588  Fragment30 MDA-MB-231 C449(1.36)  LDD1419  [24]
 LDCM0589  Fragment31 MDA-MB-231 C449(1.22)  LDD1421  [24]
 LDCM0468  Fragment33 HCT 116 C232(0.83); C449(0.86)  LDD0785  [8]
 LDCM0593  Fragment35 Ramos C449(1.24)  LDD1430  [24]
 LDCM0595  Fragment37 Ramos C449(0.97)  LDD1432  [24]
 LDCM0596  Fragment38 MDA-MB-231 C449(1.15)  LDD1433  [24]
 LDCM0566  Fragment4 MDA-MB-231 C449(12.13)  LDD1378  [24]
 LDCM0598  Fragment40 Ramos C449(1.39)  LDD1437  [24]
 LDCM0599  Fragment41 MDA-MB-231 C449(1.02)  LDD1438  [24]
 LDCM0600  Fragment42 Ramos C449(0.83)  LDD1440  [24]
 LDCM0601  Fragment43 MDA-MB-231 C449(2.36)  LDD1441  [24]
 LDCM0604  Fragment46 MDA-MB-231 C449(1.06)  LDD1445  [24]
 LDCM0605  Fragment47 MDA-MB-231 C449(1.33)  LDD1446  [24]
 LDCM0427  Fragment51 HCT 116 C232(1.02); C449(2.45)  LDD0744  [8]
 LDCM0610  Fragment52 MDA-MB-231 C449(1.01)  LDD1452  [24]
 LDCM0612  Fragment54 MDA-MB-231 C449(1.06)  LDD1456  [24]
 LDCM0614  Fragment56 Ramos C449(1.07)  LDD2205  [23]
 LDCM0569  Fragment7 MDA-MB-231 C449(0.85)  LDD1383  [24]
 LDCM0570  Fragment8 MDA-MB-231 C449(1.44)  LDD1385  [24]
 LDCM0571  Fragment9 MDA-MB-231 C449(3.64)  LDD1387  [24]
 LDCM0118  HHS-0301 DM93 Y310(3.48)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y458(3.34)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y310(20.00)  LDD0268  [7]
 LDCM0022  KB02 HCT 116 C528(1.39)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C528(1.15)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C528(1.65)  LDD0082  [8]
 LDCM0109  NEM HeLa N.A.  LDD0225  [16]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C342(1.19); C449(0.96)  LDD2099  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C449(1.09)  LDD2107  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C95(0.32)  LDD2111  [4]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C95(0.64)  LDD2120  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C449(1.02)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C342(0.28)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C342(1.41)  LDD2125  [4]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C342(0.73)  LDD2128  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C95(0.52)  LDD2134  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C95(0.39); C449(1.05)  LDD2136  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C342(1.11)  LDD2140  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C95(0.34)  LDD2144  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C95(0.27)  LDD2146  [4]
 LDCM0628  OTUB2-COV-1 HEK-293T C449(0.71)  LDD2207  [25]
 LDCM0131  RA190 MM1.R 2.10  LDD0299  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
V-type proton ATPase subunit D (ATP6V1D) V-ATPase D subunit family Q9Y5K8
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP synthase subunit O, mitochondrial (ATP5PO) ATPase delta chain family P48047
WASH complex subunit 3 (WASHC3) CCDC53 family Q9Y3C0
Exocyst complex component 8 (EXOC8) EXO84 family Q8IYI6
THO complex subunit 7 homolog (THOC7) THOC7 family Q6I9Y2
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-dependent transcription factor ATF-4 (ATF4) BZIP family P18848
Zinc finger protein 655 (ZNF655) Krueppel C2H2-type zinc-finger protein family Q8N720
Other
Click To Hide/Show 32 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Angiomotin-like protein 2 (AMOTL2) Angiomotin family Q9Y2J4
Apoptosis-stimulating of p53 protein 1 (PPP1R13B) ASPP family Q96KQ4
Calcium-binding and coiled-coil domain-containing protein 1 (CALCOCO1) CALCOCO family Q9P1Z2
DNA replication factor Cdt1 (CDT1) Cdt1 family Q9H211
Centromere protein H (CENPH) CENP-H/MCM16 family Q9H3R5
Cyclin-H (CCNH) Cyclin family P51946
Cyclin-K (CCNK) Cyclin family O75909
Protein FAM9C (FAM9C) FAM9 family Q8IZT9
Golgin subfamily A member 2 (GOLGA2) GOLGA2 family Q08379
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type II cytoskeletal 6B (KRT6B) Intermediate filament family P04259
Keratin, type II cytoskeletal 75 (KRT75) Intermediate filament family O95678
Kinesin light chain 3 (KLC3) Kinesin light chain family Q6P597
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Mediator of RNA polymerase II transcription subunit 4 (MED4) Mediator complex subunit 4 family Q9NPJ6
Microfibrillar-associated protein 1 (MFAP1) MFAP1 family P55081
Kinetochore protein NDC80 homolog (NDC80) NDC80/HEC1 family O14777
Nuclear distribution protein nudE-like 1 (NDEL1) NudE family Q9GZM8
Kinetochore protein Nuf2 (NUF2) NUF2 family Q9BZD4
Swi5-dependent recombination DNA repair protein 1 homolog (SFR1) SFR1/MEI5 family Q86XK3
SAGA-associated factor 29 (SGF29) SGF29 family Q96ES7
Kinetochore protein Spc25 (SPC25) SPC25 family Q9HBM1
Syntaxin-11 (STX11) Syntaxin family O75558
Alpha-taxilin (TXLNA) Taxilin family P40222
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Intraflagellar transport protein 20 homolog (IFT20) . Q8IY31
RUN and FYVE domain-containing protein 4 (RUFY4) . Q6ZNE9
TNFAIP3-interacting protein 1 (TNIP1) . Q15025
ZW10 interactor (ZWINT) . O95229

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
13 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
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Mass spectrometry data entry: PXD041587
20 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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