Details of the Target

General Information of Target

Target ID LDTP06250
Target Name Proteasome activator complex subunit 4 (PSME4)
Gene Name PSME4
Gene ID 23198
Synonyms
KIAA0077; Proteasome activator complex subunit 4; Proteasome activator PA200
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MEPAERAGVGEPPEPGGRPEPGPRGFVPQKEIVYNKLLPYAERLDAESDLQLAQIKCNLG
RAVQLQELWPGGLFWTRKLSTYIRLYGRKFSKEDHVLFIKLLYELVSIPKLEISMMQGFA
RLLINLLKKKELLSRADLELPWRPLYDMVERILYSKTEHLGLNWFPNSVENILKTLVKSC
RPYFPADATAEMLEEWRPLMCPFDVTMQKAITYFEIFLPTSLPPELHHKGFKLWFDELIG
LWVSVQNLPQWEGQLVNLFARLATDNIGYIDWDPYVPKIFTRILRSLNLPVGSSQVLVPR
FLTNAYDIGHAVIWITAMMGGPSKLVQKHLAGLFNSITSFYHPSNNGRWLNKLMKLLQRL
PNSVVRRLHRERYKKPSWLTPVPDSHKLTDQDVTDFVQCIIQPVLLAMFSKTGSLEAAQA
LQNLALMRPELVIPPVLERTYPALETLTEPHQLTATLSCVIGVARSLVSGGRWFPEGPTH
MLPLLMRALPGVDPNDFSKCMITFQFIATFSTLVPLVDCSSVLQERNDLTEVERELCSAT
AEFEDFVLQFMDRCFGLIESSTLEQTREETETEKMTHLESLVELGLSSTFSTILTQCSKE
IFMVALQKVFNFSTSHIFETRVAGRMVADMCRAAVKCCPEESLKLFVPHCCSVITQLTMN
DDVLNDEELDKELLWNLQLLSEITRVDGRKLLLYREQLVKILQRTLHLTCKQGYTLSCNL
LHHLLRSTTLIYPTEYCSVPGGFDKPPSEYFPIKDWGKPGDLWNLGIQWHVPSSEEVSFA
FYLLDSFLQPELVKLQHCGDGKLEMSRDDILQSLTIVHNCLIGSGNLLPPLKGEPVTNLV
PSMVSLEETKLYTGLEYDLSRENHREVIATVIRKLLNHILDNSEDDTKSLFLIIKIIGDL
LQFQGSHKHEFDSRWKSFNLVKKSMENRLHGKKQHIRALLIDRVMLQHELRTLTVEGCEY
KKIHQDMIRDLLRLSTSSYSQVRNKAQQTFFAALGAYNFCCRDIIPLVLEFLRPDRQGVT
QQQFKGALYCLLGNHSGVCLANLHDWDCIVQTWPAIVSSGLSQAMSLEKPSIVRLFDDLA
EKIHRQYETIGLDFTIPKSCVEIAELLQQSKNPSINQILLSPEKIKEGIKRQQEKNADAL
RNYENLVDTLLDGVEQRNLPWKFEHIGIGLLSLLLRDDRVLPLRAIRFFVENLNHDAIVV
RKMAISAVAGILKQLKRTHKKLTINPCEISGCPKPTQIIAGDRPDNHWLHYDSKTIPRTK
KEWESSCFVEKTHWGYYTWPKNMVVYAGVEEQPKLGRSREDMTEAEQIIFDHFSDPKFVE
QLITFLSLEDRKGKDKFNPRRFCLFKGIFRNFDDAFLPVLKPHLEHLVADSHESTQRCVA
EIIAGLIRGSKHWTFEKVEKLWELLCPLLRTALSNITVETYNDWGACIATSCESRDPRKL
HWLFELLLESPLSGEGGSFVDACRLYVLQGGLAQQEWRVPELLHRLLKYLEPKLTQVYKN
VRERIGSVLTYIFMIDVSLPNTTPTISPHVPEFTARILEKLKPLMDVDEEIQNHVMEENG
IGEEDERTQGIKLLKTILKWLMASAGRSFSTAVTEQLQLLPLFFKIAPVENDNSYDELKR
DAKLCLSLMSQGLLYPHQVPLVLQVLKQTARSSSWHARYTVLTYLQTMVFYNLFIFLNNE
DAVKDIRWLVISLLEDEQLEVREMAATTLSGLLQCNFLTMDSPMQIHFEQLCKTKLPKKR
KRDPGSVGDTIPSAELVKRHAGVLGLGACVLSSPYDVPTWMPQLLMNLSAHLNDPQPIEM
TVKKTLSNFRRTHHDNWQEHKQQFTDDQLLVLTDLLVSPCYYA
Target Bioclass
Other
Family
BLM10 family
Subcellular location
Cytoplasm, cytosol
Function
Associated component of the proteasome that specifically recognizes acetylated histones and promotes ATP- and ubiquitin-independent degradation of core histones during spermatogenesis and DNA damage response. Recognizes and binds acetylated histones via its bromodomain-like (BRDL) region and activates the proteasome by opening the gated channel for substrate entry. Binds to the core proteasome via its C-terminus, which occupies the same binding sites as the proteasomal ATPases, opening the closed structure of the proteasome via an active gating mechanism. Component of the spermatoproteasome, a form of the proteasome specifically found in testis: binds to acetylated histones and promotes degradation of histones, thereby participating actively to the exchange of histones during spermatogenesis. Also involved in DNA damage response in somatic cells, by promoting degradation of histones following DNA double-strand breaks.
Uniprot ID
Q14997
Ensemble ID
ENST00000404125.6
HGNC ID
HGNC:20635

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.A120V DBIA    Probe Info 
CAL62 SNV: p.P772L DBIA    Probe Info 
CCK81 SNV: p.L79I; p.F259L .
HCC1395 SNV: p.H1084D DBIA    Probe Info 
HUH28 SNV: p.S1058F DBIA    Probe Info 
KARPAS299 SNV: p.M1720T DBIA    Probe Info 
KYSE510 SNV: p.S1059L; p.D1743E DBIA    Probe Info 
L428 SNV: p.G253A DBIA    Probe Info 
LS180 SNV: p.R18G DBIA    Probe Info 
MDAMB453 SNV: p.R1377Ter DBIA    Probe Info 
MEWO SNV: p.P274S DBIA    Probe Info 
NCIH1155 SNV: p.A1104V DBIA    Probe Info 
NCIH1993 SNV: p.C519S .
NCIH2172 Substitution: p.W1688F DBIA    Probe Info 
RKO SNV: p.Q988R .
RPMI7951 SNV: p.A1137V DBIA    Probe Info 
SBC5 SNV: p.D800G DBIA    Probe Info 
SKMEL24 SNV: p.D1353N DBIA    Probe Info 
SNU1 Insertion: p.V1190CfsTer2 DBIA    Probe Info 
SW1271 SNV: p.L1150F DBIA    Probe Info 
VMRCRCW SNV: p.D1721N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		5.72  LDD0215  [2]
CY-1
 Probe Info  		100.00  LDD0243  [3]
STPyne
 Probe Info  		K1336(5.17); K916(10.00)  LDD0277  [4]
BTD
 Probe Info  		C710(1.96)  LDD1700  [5]
AHL-Pu-1
 Probe Info  		C1406(4.11)  LDD0170  [6]
HHS-475
 Probe Info  		Y1615(1.38)  LDD0264  [7]
DBIA
 Probe Info  		C1001(1.51); C710(1.15); C1227(0.92); C1232(0.92)  LDD0078  [8]
ATP probe
 Probe Info  		N.A.  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C1378(0.00); C1406(0.00); C631(0.00); C1100(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		C1378(0.00); C537(0.00); C1267(0.00); C1100(0.00)  LDD0036  [10]
Lodoacetamide azide
 Probe Info  		C1406(0.00); C1100(0.00); C1378(0.00); C537(0.00)  LDD0037  [10]
IPM
 Probe Info  		N.A.  LDD0005  [11]
Acrolein
 Probe Info  		N.A.  LDD0217  [12]
Methacrolein
 Probe Info  		N.A.  LDD0218  [12]
W1
 Probe Info  		C710(0.00); C958(0.00); C631(0.00); C798(0.00)  LDD0236  [13]
NAIA_5
 Probe Info  		C1378(0.00); C1100(0.00); C1267(0.00); C958(0.00)  LDD2223  [14]
HHS-482
 Probe Info  		Y1466(2.33)  LDD2239  [15]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C147
 Probe Info  		6.82  LDD1829  [16]
C163
 Probe Info  		11.16  LDD1843  [16]
C399
 Probe Info  		6.77  LDD2058  [16]
STS-1
 Probe Info  		N.A.  LDD0068  [17]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C710(1.59); C798(0.94)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C710(1.37); C798(1.13)  LDD2152  [5]
 LDCM0025  4SU-RNA DM93 C1406(4.11)  LDD0170  [6]
 LDCM0214  AC1 HCT 116 C1001(0.59); C1227(1.03); C1232(1.03); C958(1.12)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C1227(0.91); C1232(0.91); C958(0.99)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C1001(0.89); C1227(1.02); C1232(1.04); C958(0.94)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C1001(2.05); C1227(0.99); C1232(0.98); C958(0.80)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C1001(1.18); C1227(0.90); C1232(0.89); C958(0.78)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C1001(1.59); C1227(0.91); C1232(0.94); C958(0.66)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C1001(1.80); C1227(0.89); C1232(0.90); C958(0.69)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C1001(1.07); C1227(0.91); C1232(0.90); C958(0.75)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C1001(1.22); C1227(0.93); C1232(0.96); C958(0.68)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C1001(1.59); C1227(0.97); C1232(0.97); C958(0.80)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C1001(1.02); C1227(1.15); C1232(1.15); C958(0.96)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C1001(6.10); C1227(0.93); C1232(0.91); C958(0.87)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C1227(0.88); C1232(0.88); C958(1.00)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C1001(1.15); C1227(1.01); C1232(1.01); C958(0.75)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C1001(1.92); C1227(0.99); C1232(0.98); C958(0.90)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C1001(2.45); C1227(1.01); C1232(0.99); C958(0.70)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C1001(0.96); C958(1.44)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C1001(1.01); C958(1.28)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C1001(0.88); C958(1.38)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C1001(0.75); C958(1.06)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C1001(0.63); C958(1.02)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C1001(0.67); C958(1.13)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C1001(0.61); C958(0.93)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C1227(0.76); C1232(0.76); C958(1.03)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C1001(3.03); C958(1.42)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C1001(1.21); C958(1.58)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C1001(0.71); C958(1.25)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C1001(1.72); C958(1.36)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C1001(0.81); C958(0.78)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C1001(1.18); C958(1.27)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C1001(0.91); C958(1.74)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C1001(0.71); C958(1.06)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C1227(0.86); C1232(0.86); C1267(1.10); C958(1.00)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C1227(0.92); C1232(0.92); C1267(1.17); C958(1.04)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C1227(0.94); C1232(0.94); C1267(1.07); C958(1.42)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C1227(0.82); C1232(0.82); C1267(1.08); C958(1.16)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C1227(0.99); C1232(0.99); C1267(1.34); C958(1.17)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C1227(1.03); C1232(1.03); C1267(1.23); C958(1.17)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C1227(0.97); C1232(0.97); C1267(1.13); C958(1.09)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C1227(0.93); C1232(0.93); C1267(1.25); C958(1.10)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C1227(0.97); C1232(0.97); C1267(1.19); C958(0.99)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C1227(1.04); C1232(1.04); C1267(0.95); C958(0.81)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C1227(0.99); C1232(0.99); C1267(0.94); C958(0.69)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C1227(1.02); C1232(1.02); C1267(1.18); C958(0.86)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C1227(0.76); C1232(0.76); C958(1.07)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C1227(0.99); C1232(0.99); C1267(0.96); C958(0.71)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C1227(1.00); C1232(1.00); C1267(1.07); C958(0.68)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C1227(1.01); C1232(1.01); C1267(1.26); C958(0.91)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C1001(1.15); C1267(0.98); C1227(1.14); C1232(1.14)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C1001(0.83); C1267(0.96); C1227(1.10); C1232(1.11)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C1267(0.93); C1227(0.99); C1001(1.01); C1232(1.20)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C1232(0.69); C1001(0.76); C1267(0.88); C1227(1.29)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C1001(0.88); C1267(0.92); C1227(1.04); C1232(1.32)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C1267(0.47); C1232(0.86); C1227(0.89); C1001(0.97)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C1232(0.71); C1001(0.75); C1267(0.83); C1227(1.07)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C1227(0.74); C1232(0.74); C958(0.94)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C1001(0.88); C1232(0.89); C1267(0.96); C1227(0.99)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C1001(0.77); C1227(0.92); C1267(1.01); C1232(1.10)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C1001(0.81); C1267(0.81); C1232(0.93); C1227(0.97)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C1267(0.41); C1001(0.65); C1232(0.74); C1227(0.92)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C1001(0.73); C1227(0.80); C1232(0.99); C1267(0.93)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C1001(0.78); C1227(1.04); C1232(0.93); C1267(1.11)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C1001(0.85); C1227(0.90); C1232(0.79); C1267(0.83)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C1001(0.89); C1227(0.92); C1232(0.97); C1267(0.82)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C1227(0.97); C958(1.00); C1232(1.03)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C958(0.97); C1227(1.01); C1232(1.03)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C1232(0.98); C1227(0.99); C958(1.12)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C1001(0.94); C1227(1.11); C1232(1.11); C958(1.12)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C1227(0.99); C958(1.04); C1232(1.07)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C1227(0.89); C1232(0.97); C958(1.10)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C958(0.94); C1227(0.97); C1232(1.04)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C1227(0.87); C1232(0.87); C958(0.91)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C1227(0.81); C1232(0.97); C958(1.28)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C1227(0.88); C1232(0.88); C958(1.00)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C1227(0.99); C1232(0.99); C958(1.14)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C1227(1.10); C1232(1.10); C958(1.23)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C1227(1.17); C1232(1.17); C958(1.43)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C1227(1.05); C1232(1.05); C958(1.11)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C1001(0.53); C1227(1.07); C1232(1.07); C958(1.13)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C1227(0.95); C1232(0.95); C958(1.19)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C1227(1.03); C1232(1.03); C958(1.14)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C1227(1.02); C1232(1.02); C958(1.12)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C958(0.81); C1227(1.00); C1232(1.00)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C958(0.73); C1227(1.01); C1232(1.01)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C1227(0.80); C1232(0.80); C958(1.05); C1100(1.05)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C1227(0.79); C1232(0.79); C958(1.11); C1100(1.14)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C1227(0.79); C1232(0.79); C958(1.09); C1100(1.19)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C1227(0.75); C1232(0.75); C1100(1.17); C958(1.22)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C1227(0.72); C1232(0.72); C1100(0.95); C958(1.18)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C1001(0.50); C958(1.06); C1227(1.12); C1232(1.12)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C1100(0.71); C1227(0.71); C1232(0.71); C958(0.80)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C1100(1.06); C958(1.11); C1227(1.11); C1232(1.11)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C1227(0.82); C1232(0.82); C1100(0.85); C958(1.10)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C1227(0.83); C1232(0.83); C1100(1.00); C958(1.05)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C1100(0.90); C1227(1.08); C1232(1.08); C958(1.13)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C1100(0.70); C958(0.84); C1227(1.23); C1232(1.23)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C1001(0.83); C1267(0.92); C1227(1.03); C1232(1.04)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C1267(0.61); C1001(0.73); C1100(0.95); C1227(1.00)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C1267(0.79); C1001(0.89); C1227(0.94); C1232(1.03)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C1100(0.40); C1267(0.42); C1232(0.94); C1227(0.95)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C1001(0.46); C1227(1.12); C1232(1.12); C958(1.12)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C1100(0.51); C1267(0.66); C1227(1.01); C1232(1.10)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C1267(0.61); C1227(1.04); C1232(1.06); C1100(1.56)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C1267(0.53); C1227(0.99); C1001(1.04); C1232(1.05)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C1267(0.64); C1100(0.72); C1227(1.03); C1232(1.09)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C1100(0.69); C1267(0.90); C1227(1.05); C1232(1.12)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C1267(0.38); C1100(0.40); C1001(0.85); C1232(0.89)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C1100(0.31); C1267(0.32); C1227(0.82); C1232(0.89)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C1100(0.60); C1001(0.80); C1267(1.11); C1227(1.11)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C1100(0.45); C958(0.95); C1227(1.00); C1232(1.00)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C1100(0.43); C1001(0.63); C1267(1.00); C958(1.08)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C1227(0.86); C1232(0.86); C958(1.03)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C1100(0.55); C1001(0.85); C1227(0.98); C1232(0.98)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C1001(0.57); C1100(0.58); C1227(1.04); C1232(1.04)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C1100(0.33); C1001(0.52); C1267(0.89); C1227(1.32)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C1001(0.50); C1100(0.71); C1227(1.03); C1232(1.03)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C1100(0.40); C1001(0.45); C1267(0.95); C1227(1.15)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C1100(0.47); C1001(0.47); C958(1.15); C1267(1.15)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C1001(0.49); C1100(0.57); C958(0.94); C1267(1.18)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C1100(0.15); C1267(0.48); C1001(0.84); C1227(1.10)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C1100(0.86); C1267(0.88); C1227(0.95); C1232(0.95)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C1100(0.71); C1267(0.75); C1227(0.91); C1232(0.91)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C1227(0.77); C1232(0.77); C958(0.96)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C1100(0.51); C1267(0.59); C1227(0.65); C1232(0.65)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C1001(0.78); C1227(0.88); C1232(0.88); C1100(1.11)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C1227(0.79); C1232(0.79); C1267(0.80); C1001(0.83)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C1100(0.35); C1267(0.50); C1001(0.79); C1227(0.86)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C1100(0.38); C1267(0.53); C1227(0.97); C1232(0.97)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C1100(0.32); C1267(0.45); C1001(0.91); C1227(1.02)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C1100(0.72); C1001(0.79); C1267(0.83); C1227(1.02)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C1100(0.60); C1267(0.62); C1227(0.93); C1232(0.93)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C1001(0.87); C1227(0.90); C1232(0.90); C1100(1.03)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C1227(0.88); C1232(0.88); C1001(0.89); C1100(0.91)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C1227(0.86); C1232(0.86); C958(1.11)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C1001(0.70); C1100(0.78); C1227(0.88); C1232(0.88)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C1267(0.70); C1001(0.75); C1100(0.76); C1227(1.29)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C1267(0.32); C1100(0.41); C1001(0.82); C1227(0.99)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C958(0.75); C1232(1.01); C1227(1.21); C1001(2.24)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C958(0.83); C1232(0.84); C1227(1.03); C1001(3.71)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C1232(0.87); C958(0.93); C1227(1.09); C1001(2.06)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C958(1.01); C1232(1.08); C1227(1.28); C1001(2.55)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C958(0.82); C1232(1.10); C1227(1.21); C1001(1.52)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C958(0.96); C1232(1.03); C1227(1.28); C1001(1.85)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C958(0.76); C1232(1.09); C1227(1.17); C1001(1.67)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C1001(0.70); C958(0.99); C1232(1.10); C1227(1.32)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C958(0.75); C1232(1.17); C1227(1.33); C1001(1.98)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C958(0.80); C1232(1.02); C1001(1.17); C1227(1.21)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C1232(0.96); C1227(1.01); C958(1.01); C1001(1.25)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C1001(0.82); C958(1.01); C1227(1.02); C1232(1.07)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C958(0.95); C1001(1.09); C1232(1.19); C1227(1.35)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C958(0.98); C1227(1.00); C1232(1.03); C1001(1.76)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C958(0.85); C1001(0.93); C1232(1.06); C1227(1.37)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C958(0.23); C1227(1.01); C1232(1.06); C1001(2.49)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C958(0.69); C1227(0.93); C1232(0.99); C1001(1.02)  LDD0683  [8]
 LDCM0545  Acetamide MDA-MB-231 C798(0.38)  LDD2138  [5]
 LDCM0248  AKOS034007472 HCT 116 C1227(0.89); C1232(0.89); C958(1.11)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C1227(0.83); C1232(0.83); C958(0.98)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C958(0.74); C1227(0.82); C1232(0.82)  LDD0592  [8]
 LDCM0020  ARS-1620 HCC44 C1001(1.51); C710(1.15); C1227(0.92); C1232(0.92)  LDD0078  [8]
 LDCM0200  BPK-25 T cell C1000, C1001(4.13)  LDD0516  [18]
 LDCM0498  BS-3668 MDA-MB-231 C958(0.57); C798(0.71)  LDD2091  [5]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [12]
 LDCM0367  CL1 HCT 116 C1267(0.55); C958(0.75); C1227(1.10); C1232(1.10)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C1267(0.61); C958(0.68); C1227(1.51); C1232(1.51)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C1001(0.62); C1227(0.93); C1232(0.93); C958(1.06)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C1227(0.80); C1232(0.80); C958(1.03)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C1227(0.83); C1232(0.83); C958(1.03)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C1227(0.83); C1232(0.83); C958(0.98)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C1227(0.73); C1232(0.73); C958(0.99)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C958(0.95); C1232(1.02); C1227(1.19)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C958(0.84); C1232(0.93); C1227(1.04)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C958(0.99); C1232(1.03); C1227(1.24)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C958(0.90); C1232(1.07); C1227(1.19)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C958(0.97); C1232(1.14); C1227(1.34)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C958(0.41); C1267(0.73); C1227(1.44); C1232(1.44)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C958(0.81); C1232(1.05); C1227(1.25)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C958(0.88); C1232(0.98); C1227(1.20)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C958(0.92); C1227(1.01); C1232(1.01)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C958(0.82); C1227(1.03); C1232(1.03)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C958(0.79); C1227(1.04); C1232(1.04)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C958(0.86); C1227(0.89); C1232(0.89)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C958(0.88); C1227(0.97); C1232(0.97)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C1100(0.33); C958(0.45); C1227(0.78); C1232(0.78)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C1100(0.91); C1227(0.93); C1232(0.93); C958(1.07)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C1100(0.80); C958(0.96); C1227(0.99); C1232(0.99)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C1267(0.50); C958(1.06); C1227(1.45); C1232(1.45)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C1100(1.11); C958(1.16); C1227(1.16); C1232(1.16)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C1100(0.97); C1267(1.08); C1001(1.20); C1232(1.68)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C1100(0.75); C1267(0.80); C1227(0.95); C1232(1.00)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C1267(0.46); C1100(0.59); C1232(1.04); C1227(1.05)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C1267(0.53); C1100(0.54); C1232(0.97); C1227(0.99)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C1001(0.62); C1100(0.85); C1227(1.08); C1232(1.08)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C958(0.72); C1100(0.80); C1267(1.03); C1227(1.17)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C1100(0.84); C1001(0.96); C1227(0.96); C1232(0.96)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C1100(0.54); C958(1.12); C1267(1.13); C1001(1.15)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C958(0.39); C1267(0.79); C1227(1.29); C1232(1.29)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C1267(0.43); C958(0.89); C1227(0.94); C1232(0.94)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C1267(0.62); C958(0.86); C1227(1.54); C1232(1.54)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C958(0.89); C1267(1.21); C1227(1.24); C1232(1.24)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C958(0.73); C1227(1.07); C1232(1.07); C1001(1.80)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C1001(0.67); C1227(0.82); C1232(0.82); C958(1.23)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C1001(0.84); C958(1.03); C1227(1.11); C1232(1.11)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C1267(0.53); C958(0.94); C1227(1.00); C1232(1.00)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C1227(0.98); C1232(0.98); C958(1.13); C1001(1.30)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C958(0.87); C1001(1.07); C1227(1.08); C1232(1.08)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C958(0.62); C1227(1.20); C1232(1.20); C1001(5.14)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C1227(1.00); C1232(1.00); C958(1.04); C1001(1.20)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C1001(1.29); C1227(1.37); C1232(1.37); C958(0.85)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C1001(0.99); C1227(1.45); C1232(1.45); C958(0.89)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C1001(0.99); C1227(1.19); C1232(1.19); C958(1.01)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C1001(0.99); C1227(1.24); C1232(1.24); C958(1.05)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C1001(1.03); C1227(1.24); C1232(1.24); C958(1.01)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C1001(2.00); C1227(1.50); C1232(1.50); C958(0.97)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C1227(0.99); C1232(0.99); C1267(0.78); C958(1.02)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C1001(1.37); C1227(1.28); C1232(1.28); C958(1.19)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C1001(1.68); C1100(1.15); C1267(0.72); C958(0.88)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C1001(0.73); C1100(1.52); C1267(0.98); C958(0.97)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C1001(1.05); C1100(1.10); C1267(0.59); C958(0.66)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C1001(0.91); C1100(0.83); C1267(0.72); C958(0.76)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C1001(1.85); C1100(0.76); C1267(1.07); C958(0.73)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C1001(1.43); C1100(0.93); C1267(0.80); C958(0.79)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C1001(2.33); C1100(0.64); C1267(0.87); C958(0.69)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C1001(1.21); C1100(0.70); C1267(0.87); C958(0.70)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C1227(1.02); C1232(1.02); C1267(0.85); C958(0.86)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C1001(14.52); C1100(0.92); C1267(0.64); C958(0.58)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C1001(1.26); C1100(1.07); C1267(0.97); C958(0.89)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C1001(2.81); C1100(0.47); C1267(0.76); C958(0.44)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C1001(4.43); C1100(0.65); C1267(0.87); C958(0.39)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C1001(1.40); C1100(1.22); C1267(0.90); C958(0.65)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C1001(1.34); C1100(0.76); C1267(0.92); C958(0.65)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C1001(0.44); C958(0.97)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C1001(0.78); C958(0.99)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C1001(0.57); C958(0.86)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C1001(0.36); C958(0.90)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C1227(0.99); C1232(0.99); C1267(1.31); C958(1.00)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C1001(0.55); C958(0.98)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C1001(0.53); C958(1.17)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C1001(0.46); C958(1.14)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C1001(2.00); C958(0.91)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C1001(3.52); C958(0.78)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C1001(0.66); C958(1.06)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C1001(1.44); C958(1.00)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C1001(3.74); C958(0.63)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C1001(0.48); C958(1.09)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C1001(0.63); C958(1.07)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C1227(1.13); C1232(1.13); C1267(0.67); C958(0.89)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C1001(0.59); C958(0.93)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C1001(1.04); C1232(1.24); C1267(1.78); C958(1.12)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C1001(1.08); C1232(1.18); C1267(1.29); C958(1.02)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C1001(1.66); C1232(0.96); C1267(0.78); C958(1.01)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C1001(0.89); C1232(1.28); C1267(0.88); C958(0.98)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C1001(1.20); C1232(1.13); C1267(0.81); C958(1.08)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C1001(1.08); C1232(1.11); C1267(1.21); C958(0.90)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C1001(1.86); C1232(1.00); C1267(0.79); C958(0.94)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C1001(3.32); C1232(0.88); C1267(0.85); C958(0.93)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C1001(1.80); C1232(1.14); C1267(1.08); C958(1.00)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C1227(1.29); C1232(1.29); C1267(0.83); C958(1.17)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C1001(1.29); C1232(0.85); C1267(0.77); C958(1.03)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C1001(1.44); C1232(0.93); C1267(0.85); C958(0.88)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C1001(1.65); C1232(1.05); C1267(1.14); C958(1.05)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C1001(3.46); C1232(1.09); C1267(0.80); C958(1.04)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C1001(1.74); C1232(1.08); C1267(1.22); C958(0.93)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C1227(0.91); C1232(0.91); C958(1.04)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C1227(0.88); C1232(0.88); C958(0.78)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C1227(0.85); C1232(0.85); C958(0.97)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C1227(0.94); C1232(0.94); C958(0.92)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C1227(1.26); C1232(1.26); C1267(0.57); C958(0.32)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C1227(0.95); C1232(0.95); C958(1.02)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C1227(0.94); C1232(0.94); C958(0.96)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C1227(1.01); C1232(1.01); C958(0.61)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C1227(1.01); C1232(1.01); C958(0.80)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C1227(0.95); C1232(0.95); C958(0.51)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C1227(0.97); C1232(0.97); C958(1.00)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C1227(0.86); C1232(0.86); C958(1.09)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C1227(0.88); C1232(0.88); C958(1.10)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C1227(0.86); C1232(0.86); C958(0.83)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C1227(0.94); C1232(0.94); C958(0.51)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C1227(1.14); C1232(1.14); C1267(0.68); C958(0.92)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C1227(0.94); C1232(0.94); C958(0.53)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C1001(1.40); C1227(1.07); C1232(1.07); C958(0.93)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C1001(1.45); C1227(0.97); C1232(0.97); C958(0.90)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C1001(0.94); C1227(0.92); C1232(0.92); C958(0.91)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C1001(1.28); C1227(0.84); C1232(0.84); C958(0.86)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C1001(1.57); C1227(1.06); C1232(1.06); C958(0.82)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C1001(0.93); C1227(1.16); C1232(1.16); C958(1.00)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C1001(0.94); C1227(0.90); C1232(0.90); C958(1.05)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C1001(0.68); C1227(0.98); C1232(0.98); C958(1.01)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C1001(0.64); C1227(1.14); C1232(1.14); C958(0.88)  LDD0811  [8]
 LDCM0495  E2913 HEK-293T C710(0.85); C958(1.19); C1267(1.19); C737(2.13)  LDD1698  [19]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C710(2.49); C798(1.83)  LDD1702  [5]
 LDCM0202  EV-93 T cell C1000, C1001(14.63)  LDD0514  [18]
 LDCM0625  F8 Ramos C710(0.99)  LDD2187  [20]
 LDCM0572  Fragment10 Ramos C1840(1.11)  LDD1390  [21]
 LDCM0573  Fragment11 Ramos C1840(3.45)  LDD1392  [21]
 LDCM0574  Fragment12 MDA-MB-231 C1840(20.00)  LDD1468  [21]
 LDCM0575  Fragment13 MDA-MB-231 C1840(1.65)  LDD1395  [21]
 LDCM0576  Fragment14 MDA-MB-231 C1840(2.75)  LDD1397  [21]
 LDCM0577  Fragment15 Ramos C1840(1.72)  LDD1400  [21]
 LDCM0579  Fragment20 MDA-MB-231 C1840(1.31)  LDD1402  [21]
 LDCM0580  Fragment21 Ramos C1840(1.11)  LDD1405  [21]
 LDCM0581  Fragment22 MDA-MB-231 C1840(1.28)  LDD1406  [21]
 LDCM0582  Fragment23 Ramos C1840(1.20)  LDD1409  [21]
 LDCM0583  Fragment24 Ramos C1840(1.63)  LDD1410  [21]
 LDCM0585  Fragment26 Ramos C1840(1.14)  LDD1412  [21]
 LDCM0578  Fragment27 Ramos C1840(0.90)  LDD1414  [21]
 LDCM0586  Fragment28 MDA-MB-231 C1840(1.05)  LDD1415  [21]
 LDCM0587  Fragment29 MDA-MB-231 C1840(1.16)  LDD1417  [21]
 LDCM0588  Fragment30 Ramos C1840(1.34)  LDD1420  [21]
 LDCM0589  Fragment31 Ramos C1840(0.96)  LDD1422  [21]
 LDCM0590  Fragment32 Ramos C1840(1.72)  LDD1424  [21]
 LDCM0468  Fragment33 HCT 116 C1001(1.52); C1232(1.19); C1267(0.82); C958(0.89)  LDD0785  [8]
 LDCM0592  Fragment34 Ramos C1840(1.04)  LDD1428  [21]
 LDCM0593  Fragment35 Ramos C1840(0.95)  LDD1430  [21]
 LDCM0595  Fragment37 Ramos C1840(1.04)  LDD1432  [21]
 LDCM0596  Fragment38 Ramos C1840(1.28)  LDD1434  [21]
 LDCM0566  Fragment4 Ramos C1840(1.72)  LDD1379  [21]
 LDCM0599  Fragment41 MDA-MB-231 C1840(20.00)  LDD1438  [21]
 LDCM0600  Fragment42 Ramos C1840(1.00)  LDD1440  [21]
 LDCM0604  Fragment46 MDA-MB-231 C1840(1.25)  LDD1445  [21]
 LDCM0427  Fragment51 HCT 116 C1100(0.41); C1267(0.63); C958(0.32)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C1840(1.27)  LDD1453  [21]
 LDCM0614  Fragment56 Ramos C1840(1.36)  LDD1459  [21]
 LDCM0569  Fragment7 MDA-MB-231 C1840(1.31)  LDD1383  [21]
 LDCM0570  Fragment8 MDA-MB-231 C1840(2.08)  LDD1385  [21]
 LDCM0571  Fragment9 MDA-MB-231 C1840(1.48)  LDD1387  [21]
 LDCM0116  HHS-0101 DM93 Y1615(1.38)  LDD0264  [7]
 LDCM0117  HHS-0201 DM93 Y1615(1.31)  LDD0265  [7]
 LDCM0118  HHS-0301 DM93 Y1615(0.70)  LDD0266  [7]
 LDCM0119  HHS-0401 DM93 Y1615(1.61)  LDD0267  [7]
 LDCM0120  HHS-0701 DM93 Y1615(2.23)  LDD0268  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [12]
 LDCM0022  KB02 HCT 116 C1267(1.09)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C1267(0.90)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C1267(0.56)  LDD0082  [8]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C798(0.72)  LDD2089  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C958(0.86)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C710(1.11); C798(0.90)  LDD2093  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C637(0.80)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C958(0.86)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C710(1.29); C798(0.95)  LDD2099  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C958(1.33)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C710(0.98); C798(0.90); C637(0.87)  LDD2107  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C710(0.74); C798(0.68)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C710(1.42); C798(1.03)  LDD2111  [5]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C798(0.41)  LDD2115  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C637(2.18)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C637(1.25)  LDD2118  [5]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C710(1.62)  LDD2119  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C710(1.01); C637(0.55)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C637(3.55)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C710(1.01); C958(0.70); C798(0.86)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C637(2.84)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C710(1.15); C958(1.12); C637(0.66); C638(0.66)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C710(1.30); C958(0.73); C798(0.73)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C710(1.58)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C710(1.76); C958(1.01)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C710(1.04); C958(0.94); C798(0.91)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C710(1.96)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C710(0.97); C958(0.82); C798(0.75)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C710(1.58); C637(1.40)  LDD2144  [5]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C710(0.95); C798(0.85); C637(0.70)  LDD2146  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C710(0.59); C958(0.39); C798(0.63)  LDD2150  [5]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C958(1.34)  LDD2153  [5]
 LDCM0021  THZ1 HCT 116 C1001(1.26)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calcium-binding and coiled-coil domain-containing protein 2 (CALCOCO2) CALCOCO family Q13137
NUT family member 1 (NUTM1) NUT family Q86Y26

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
13 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
14 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
15 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
18 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
19 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
20 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
21 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.