Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment27					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	20.0
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	20.0
LDTP05992	Bleomycin hydrolase (BLMH)				C73	3.1
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	2.8
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	1.8
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	1.7
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	1.6
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.5
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	1.5
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C193	1.5
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	1.5
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.4
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	1.4
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	1.4
LDTP15311	Deaminated glutathione amidase (NIT1)				C203	1.4
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	1.3
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.3
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	1.3
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.3
LDTP12190	NmrA-like family domain-containing protein 1 (NMRAL1)				C154	1.3
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.3
LDTP10801	ATPase WRNIP1 (WRNIP1)				C272	1.3
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.3
LDTP04424	Galactokinase (GALK1)				C182	1.3
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.3
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	1.2
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	1.2
LDTP02502	Thioredoxin (TXN)				C32	1.2
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.2
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.2
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.2
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	1.2
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	1.2
LDTP06211	Caspase-8 (CASP8)				C360	1.2
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	1.2
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	1.2
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.1
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	1.1
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	1.1
LDTP03786	Glutaredoxin-1 (GLRX)				C23	1.1
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	1.1
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	1.1
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.1
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	1.1
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	1.1
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.1
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.1
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	1.1
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.1
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	1.1
LDTP02022	Thymidine kinase, cytosolic (TK1)				C230	1.1
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	1.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.1
LDTP11111	Tudor-interacting repair regulator protein (NUDT16L1)				C88	1.1
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	1.1
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	1.1
LDTP04103	Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3)				C207	1.1
LDTP01245	Enoyl-CoA delta isomerase 2 (ECI2)				C380	1.1
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C100	1.1
LDTP03644	Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)				C120	1.1
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C641	1.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	1.1
LDTP06603	Cyclin-dependent kinase inhibitor 3 (CDKN3)				C39	1.0
LDTP02672	Elongation factor 2 (EEF2)				C136	1.0
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C179	1.0
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	1.0
LDTP02672	Elongation factor 2 (EEF2)				C41	1.0
LDTP00601	UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)				C620	1.0
LDTP10386	ERO1-like protein alpha (ERO1A)				C37	1.0
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	1.0
LDTP04306	Adenosine 5'-monophosphoramidase HINT1 (HINT1)				C84	1.0
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.0
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.0
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	1.0
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	1.0
LDTP03400	Deoxycytidine kinase (DCK)				C45	1.0
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	1.0
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	1.0
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.0
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	1.0
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	1.0
LDTP03806	ADP-ribosylation factor-like protein 3 (ARL3)				C174	1.0
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	1.0
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.0
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	1.0
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.0
LDTP09446	Ribonuclease H2 subunit C (RNASEH2C)				C34	1.0
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	1.0
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	1.0
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.0
LDTP07110	Putative transferase CAF17, mitochondrial (IBA57)				C170	1.0
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.0
LDTP04689	Adenosine kinase (ADK)				C353	1.0
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	0.9
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	0.9
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	0.9
LDTP05289	AMP deaminase 2 (AMPD2)				C107	0.9
LDTP04251	Elongation factor Tu, mitochondrial (TUFM)				C147	0.9
LDTP04374	Dynamin-2 (DNM2)				C27	0.9
LDTP14159	Ubiquitin carboxyl-terminal hydrolase 16 (USP16)				C205	0.9
LDTP04987	26S proteasome regulatory subunit 10B (PSMC6)				C170	0.8
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	0.8
LDTP11340	Cyclin-dependent kinase 19 (CDK19)				C349	0.8
LDTP10177	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2)				C64	0.6

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	1.3
LDTP01574	Importin-7 (IPO7)				C757	1.2
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	1.2
LDTP04662	Exportin-2 (CSE1L)				C842	1.1
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	1.1
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	1.1
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	1.1
LDTP13661	Sorting nexin-6 (SNX6)				C264	1.1
LDTP04801	Gasdermin-D (GSDMD)				C268	1.1
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.0
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.0
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	1.0
LDTP00501	Exportin-1 (XPO1)				C34	1.0
LDTP00501	Exportin-1 (XPO1)				C528	0.8
LDTP03327	ATP synthase subunit alpha, mitochondrial (ATP5F1A)				C294	0.8

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	1.2
LDTP03969	Signal transducer and activator of transcription 1-alpha/beta (STAT1)				C492	1.1
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.1
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	1.0
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.0
LDTP01191	Zinc finger protein 217 (ZNF217)				C286	1.0

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12412	Reticulon-4 (RTN4)				C1101	2.0
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	1.8
LDTP03244	Cofilin-1 (CFL1)				C80	1.5
LDTP04487	Cyclin-H (CCNH)				C244	1.4
LDTP07755	Dynamin-binding protein (DNMBP)				C691	1.3
LDTP12651	TBC1 domain family member 23 (TBC1D23)				C283	1.3
LDTP02205	Tubulin beta chain (TUBB)				C239	1.3
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	1.2
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	1.2
LDTP05867	Treacle protein (TCOF1)				C38	1.2
LDTP01532	ZW10 interactor (ZWINT)				C54	1.2
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	1.2
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	1.2
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	1.2
LDTP13580	Coronin-1C (CORO1C)				C420	1.1
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	1.1
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C561	1.1
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	1.1
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.1
LDTP06684	Sister chromatid cohesion protein PDS5 homolog A (PDS5A)				C242	1.1
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	1.1
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.1
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	1.1
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.1
LDTP04092	Crk-like protein (CRKL)				C249	1.1
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	1.1
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	1.1
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	1.1
LDTP18494	Tropomodulin-3 (TMOD3)				C132	1.1
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	1.1
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	1.1
LDTP00202	AH receptor-interacting protein (AIP)				C122	1.0
LDTP10864	Calponin-2 (CNN2)				C215	1.0
LDTP00431	Kinetochore protein NDC80 homolog (NDC80)				C449	1.0
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	1.0
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	1.0
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.0
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	1.0
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	1.0
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	1.0
LDTP04902	Actin-related protein 3 (ACTR3)				C235	1.0
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	1.0
LDTP10700	KH domain-containing RNA-binding protein QKI (QKI)				C35	1.0
LDTP12571	LanC-like protein 2 (LANCL2)				C187	1.0
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	1.0
LDTP13837	Trafficking protein particle complex subunit 4 (TRAPPC4)				C195	1.0
LDTP02205	Tubulin beta chain (TUBB)				C354	1.0
LDTP04517	Transcription initiation factor IIA subunit 2 (GTF2A2)				C68	1.0
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	1.0
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	1.0
LDTP05930	SNW domain-containing protein 1 (SNW1)				C250	1.0
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	1.0
LDTP04971	Small ribosomal subunit protein uS12 (RPS23)				C90	1.0
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	1.0
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	1.0
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.0
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	1.0
LDTP12754	H/ACA ribonucleoprotein complex subunit 2 (NHP2)				C18	1.0
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	1.0
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	1.0
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	1.0
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.0
LDTP10864	Calponin-2 (CNN2)				C164	1.0
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	1.0
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	0.9
LDTP13964	MOB-like protein phocein (MOB4)				C134	0.9
LDTP00430	Transcription elongation regulator 1 (TCERG1)				C1062	0.9
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	0.9
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	0.9
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	0.9
LDTP10284	Multivesicular body subunit 12A (MVB12A)				C231	0.9
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	0.9
LDTP03860	Stress-70 protein, mitochondrial (HSPA9)				C317	0.9
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	0.9
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	0.9
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	0.9
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	0.9
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	0.9
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	0.9
LDTP14351	RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1)				C179	0.8
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	0.8

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.