Details of the Target

General Information of Target

Target ID LDTP01495
Target Name E3 ubiquitin-protein ligase UBR5 (UBR5)
Gene Name UBR5
Gene ID 51366
Synonyms
EDD; EDD1; HYD; KIAA0896; E3 ubiquitin-protein ligase UBR5; EC 2.3.2.26; E3 ubiquitin-protein ligase, HECT domain-containing 1; HECT-type E3 ubiquitin transferase UBR5; Hyperplastic discs protein homolog; hHYD; Progestin-induced protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSIHFVVHPLPGTEDQLNDRLREVSEKLNKYNLNSHPPLNVLEQATIKQCVVGPNHAAF
LLEDGRVCRIGFSVQPDRLELGKPDNNDGSKLNSNSGAGRTSRPGRTSDSPWFLSGSETL
GRLAGNTLGSRWSSGVGGSGGGSSGRSSAGARDSRRQTRVIRTGRDRGSGLLGSQPQPVI
PASVIPEELISQAQVVLQGKSRSVIIRELQRTNLDVNLAVNNLLSRDDEDGDDGDDTASE
SYLPGEDLMSLLDADIHSAHPSVIIDADAMFSEDISYFGYPSFRRSSLSRLGSSRVLLLP
LERDSELLRERESVLRLRERRWLDGASFDNERGSTSKEGEPNLDKKNTPVQSPVSLGEDL
QWWPDKDGTKFICIGALYSELLAVSSKGELYQWKWSESEPYRNAQNPSLHHPRATFLGLT
NEKIVLLSANSIRATVATENNKVATWVDETLSSVASKLEHTAQTYSELQGERIVSLHCCA
LYTCAQLENSLYWWGVVPFSQRKKMLEKARAKNKKPKSSAGISSMPNITVGTQVCLRNNP
LYHAGAVAFSISAGIPKVGVLMESVWNMNDSCRFQLRSPESLKNMEKASKTTEAKPESKQ
EPVKTEMGPPPSPASTCSDASSIASSASMPYKRRRSTPAPKEEEKVNEEQWSLREVVFVE
DVKNVPVGKVLKVDGAYVAVKFPGTSSNTNCQNSSGPDADPSSLLQDCRLLRIDELQVVK
TGGTPKVPDCFQRTPKKLCIPEKTEILAVNVDSKGVHAVLKTGNWVRYCIFDLATGKAEQ
ENNFPTSSIAFLGQNERNVAIFTAGQESPIILRDGNGTIYPMAKDCMGGIRDPDWLDLPP
ISSLGMGVHSLINLPANSTIKKKAAVIIMAVEKQTLMQHILRCDYEACRQYLMNLEQAVV
LEQNLQMLQTFISHRCDGNRNILHACVSVCFPTSNKETKEEEEAERSERNTFAERLSAVE
AIANAISVVSSNGPGNRAGSSSSRSLRLREMMRRSLRAAGLGRHEAGASSSDHQDPVSPP
IAPPSWVPDPPAMDPDGDIDFILAPAVGSLTTAATGTGQGPSTSTIPGPSTEPSVVESKD
RKANAHFILKLLCDSVVLQPYLRELLSAKDARGMTPFMSAVSGRAYPAAITILETAQKIA
KAEISSSEKEEDVFMGMVCPSGTNPDDSPLYVLCCNDTCSFTWTGAEHINQDIFECRTCG
LLESLCCCTECARVCHKGHDCKLKRTSPTAYCDCWEKCKCKTLIAGQKSARLDLLYRLLT
ATNLVTLPNSRGEHLLLFLVQTVARQTVEHCQYRPPRIREDRNRKTASPEDSDMPDHDLE
PPRFAQLALERVLQDWNALKSMIMFGSQENKDPLSASSRIGHLLPEEQVYLNQQSGTIRL
DCFTHCLIVKCTADILLLDTLLGTLVKELQNKYTPGRREEAIAVTMRFLRSVARVFVILS
VEMASSKKKNNFIPQPIGKCKRVFQALLPYAVEELCNVAESLIVPVRMGIARPTAPFTLA
STSIDAMQGSEELFSVEPLPPRPSSDQSSSSSQSQSSYIIRNPQQRRISQSQPVRGRDEE
QDDIVSADVEEVEVVEGVAGEEDHHDEQEEHGEENAEAEGQHDEHDEDGSDMELDLLAAA
ETESDSESNHSNQDNASGRRSVVTAATAGSEAGASSVPAFFSEDDSQSNDSSDSDSSSSQ
SDDIEQETFMLDEPLERTTNSSHANGAAQAPRSMQWAVRNTQHQRAASTAPSSTSTPAAS
SAGLIYIDPSNLRRSGTISTSAAAAAAALEASNASSYLTSASSLARAYSIVIRQISDLMG
LIPKYNHLVYSQIPAAVKLTYQDAVNLQNYVEEKLIPTWNWMVSIMDSTEAQLRYGSALA
SAGDPGHPNHPLHASQNSARRERMTAREEASLRTLEGRRRATLLSARQGMMSARGDFLNY
ALSLMRSHNDEHSDVLPVLDVCSLKHVAYVFQALIYWIKAMNQQTTLDTPQLERKRTREL
LELGIDNEDSEHENDDDTNQSATLNDKDDDSLPAETGQNHPFFRRSDSMTFLGCIPPNPF
EVPLAEAIPLADQPHLLQPNARKEDLFGRPSQGLYSSSASSGKCLMEVTVDRNCLEVLPT
KMSYAANLKNVMNMQNRQKKEGEEQPVLPEETESSKPGPSAHDLAAQLKSSLLAEIGLTE
SEGPPLTSFRPQCSFMGMVISHDMLLGRWRLSLELFGRVFMEDVGAEPGSILTELGGFEV
KESKFRREMEKLRNQQSRDLSLEVDRDRDLLIQQTMRQLNNHFGRRCATTPMAVHRVKVT
FKDEPGEGSGVARSFYTAIAQAFLSNEKLPNLECIQNANKGTHTSLMQRLRNRGERDRER
EREREMRRSSGLRAGSRRDRDRDFRRQLSIDTRPFRPASEGNPSDDPEPLPAHRQALGER
LYPRVQAMQPAFASKITGMLLELSPAQLLLLLASEDSLRARVDEAMELIIAHGRENGADS
ILDLGLVDSSEKVQQENRKRHGSSRSVVDMDLDDTDDGDDNAPLFYQPGKRGFYTPRPGK
NTEARLNCFRNIGRILGLCLLQNELCPITLNRHVIKVLLGRKVNWHDFAFFDPVMYESLR
QLILASQSSDADAVFSAMDLAFAIDLCKEEGGGQVELIPNGVNIPVTPQNVYEYVRKYAE
HRMLVVAEQPLHAMRKGLLDVLPKNSLEDLTAEDFRLLVNGCGEVNVQMLISFTSFNDES
GENAEKLLQFKRWFWSIVEKMSMTERQDLVYFWTSSPSLPASEEGFQPMPSITIRPPDDQ
HLPTANTCISRLYVPLYSSKQILKQKLLLAIKTKNFGFV
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function
E3 ubiquitin-protein ligase which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. Involved in maturation and/or transcriptional regulation of mRNA by activating CDK9 by polyubiquitination. May play a role in control of cell cycle progression. May have tumor suppressor function. Regulates DNA topoisomerase II binding protein (TopBP1) in the DNA damage response. Plays an essential role in extraembryonic development. Ubiquitinates acetylated PCK1. Also acts as a regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spreading of ubiquitinated chromatin at damaged chromosomes.
Uniprot ID
O95071
Ensemble ID
ENST00000220959.8
HGNC ID
HGNC:16806

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.L214R DBIA    Probe Info 
AN3CA Insertion: p.E2121RfsTer13 DBIA    Probe Info 
AU565 SNV: p.H1585N DBIA    Probe Info 
CAL27 SNV: p.H1385D DBIA    Probe Info 
CCK81 Deletion: p.E2121KfsTer28 DBIA    Probe Info 
DU145 Deletion: p.E2121KfsTer28
SNV: p.E593K;p.R1541S		 DBIA    Probe Info 
HEC1 SNV: p.A2106T DBIA    Probe Info 
HEC1B SNV: p.A2106T .
HT115 SNV: p.R413Q; p.E1104A; p.L2066I; p.R2246W DBIA    Probe Info 
IGROV1 Deletion: p.E2121KfsTer28
SNV: p.N2093S		 DBIA    Probe Info 
IM95 SNV: p.M1961T DBIA    Probe Info 
JHH7 SNV: p.S1759T .
KYSE150 SNV: p.Q1533Ter DBIA    Probe Info 
KYSE410 SNV: p.M1114T DBIA    Probe Info 
LS180 Deletion: p.E2121KfsTer28 DBIA    Probe Info 
MFE319 SNV: p.N1084T; p.Q1348H DBIA    Probe Info 
MOLT4 SNV: p.A485T; p.A1765V; p.A2647T IA-alkyne    Probe Info 
NCIH1155 SNV: p.S327L; p.Q1715Ter DBIA    Probe Info 
NCIH1703 SNV: p.S1626G DBIA    Probe Info 
NCIH358 SNV: p.C916Y DBIA    Probe Info 
NCIH446 SNV: p.V900F DBIA    Probe Info 
OSRC2 SNV: p.I48V DBIA    Probe Info 
OVCAR8 SNV: p.A823V DBIA    Probe Info 
REH SNV: p.R1541K DBIA    Probe Info 
RH30 SNV: p.M629T DBIA    Probe Info 
RH41 Deletion: p.Q1410_K1412del DBIA    Probe Info 
RKO Deletion: p.E2121KfsTer28 DBIA    Probe Info 
RL952 SNV: p.V1406M DBIA    Probe Info 
SKMEL2 SNV: p.A963V DBIA    Probe Info 
SKMEL3 SNV: p.L892I DBIA    Probe Info 
SKN SNV: p.I1955M DBIA    Probe Info 
SKNMC Deletion: p.L1892_L1895delinsF DBIA    Probe Info 
SUIT2 SNV: p.R2439S DBIA    Probe Info 
SW756 SNV: p.S1566L DBIA    Probe Info 
TOV21G Insertion: p.T744NfsTer29 DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.35  LDD0215  [2]
STPyne
 Probe Info  		K2656(7.63)  LDD0277  [3]
Probe 1
 Probe Info  		Y1830(7.79)  LDD3495  [4]
BTD
 Probe Info  		C739(1.26)  LDD1700  [5]
AZ-9
 Probe Info  		10.00  LDD2154  [6]
AHL-Pu-1
 Probe Info  		C739(4.89); C2314(3.17); C2267(7.60)  LDD0168  [7]
Acrolein
 Probe Info  		N.A.  LDD0221  [8]
DBIA
 Probe Info  		C883(0.84); C888(0.84)  LDD0078  [9]
ATP probe
 Probe Info  		K2656(0.00); K663(0.00); K669(0.00)  LDD0199  [10]
4-Iodoacetamidophenylacetylene
 Probe Info  		C2267(0.00); C2084(0.00); C1093(0.00); C2314(0.00)  LDD0038  [11]
IA-alkyne
 Probe Info  		C1093(0.00); C2539(0.00)  LDD0032  [12]
Lodoacetamide azide
 Probe Info  		C2267(0.00); C2084(0.00); C1391(0.00); C2094(0.00)  LDD0037  [11]
NAIA_4
 Probe Info  		C730(0.00); C2314(0.00)  LDD2226  [13]
TFBX
 Probe Info  		N.A.  LDD0027  [14]
WYneN
 Probe Info  		C730(0.00); C2314(0.00)  LDD0021  [15]
WYneO
 Probe Info  		N.A.  LDD0022  [15]
Compound 10
 Probe Info  		C2084(0.00); C2094(0.00); C2267(0.00); C730(0.00)  LDD2216  [16]
Compound 11
 Probe Info  		C2084(0.00); C2094(0.00)  LDD2213  [16]
IPM
 Probe Info  		C2314(0.00); C739(0.00); C2084(0.00); C2267(0.00)  LDD0005  [15]
NPM
 Probe Info  		N.A.  LDD0016  [15]
VSF
 Probe Info  		N.A.  LDD0007  [15]
W1
 Probe Info  		C730(0.00); C2314(0.00)  LDD0236  [17]
AOyne
 Probe Info  		6.40  LDD0443  [18]
NAIA_5
 Probe Info  		C2267(0.00); C826(0.00); C739(0.00); C1942(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [19]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C739(0.78)  LDD2142  [5]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C739(0.88)  LDD2112  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C739(0.94); C2314(1.22); C1291(1.00)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C739(0.99)  LDD2152  [5]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C739(1.01)  LDD2103  [5]
 LDCM0025  4SU-RNA HEK-293T C739(4.89); C2314(3.17); C2267(7.60)  LDD0168  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C739(3.53); C2314(2.43); C2267(5.04)  LDD0169  [7]
 LDCM0214  AC1 HCT 116 C1199(1.11); C1211(1.11); C1232(1.11); C1234(1.11)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C1199(1.30); C1207(1.31); C1208(1.55); C1211(0.79)  LDD0532  [9]
 LDCM0216  AC100 HCT 116 C1199(0.73); C1207(0.61); C1211(0.70); C1232(0.67)  LDD0533  [9]
 LDCM0217  AC101 HCT 116 C1199(0.83); C1207(0.75); C1211(0.83); C1232(0.66)  LDD0534  [9]
 LDCM0218  AC102 HCT 116 C1199(0.74); C1207(0.75); C1211(0.78); C1232(0.71)  LDD0535  [9]
 LDCM0219  AC103 HCT 116 C1199(0.85); C1207(0.69); C1211(0.86); C1232(0.63)  LDD0536  [9]
 LDCM0220  AC104 HCT 116 C1199(0.76); C1207(0.61); C1211(0.75); C1232(0.71)  LDD0537  [9]
 LDCM0221  AC105 HCT 116 C1199(0.86); C1207(0.58); C1211(0.82); C1232(0.65)  LDD0538  [9]
 LDCM0222  AC106 HCT 116 C1199(0.87); C1207(0.78); C1211(0.89); C1232(0.74)  LDD0539  [9]
 LDCM0223  AC107 HCT 116 C1199(0.84); C1207(0.80); C1211(0.81); C1232(0.70)  LDD0540  [9]
 LDCM0224  AC108 HCT 116 C1199(0.87); C1207(0.61); C1211(0.89); C1232(0.71)  LDD0541  [9]
 LDCM0225  AC109 HCT 116 C1199(0.70); C1207(0.72); C1211(0.85); C1232(0.74)  LDD0542  [9]
 LDCM0226  AC11 HCT 116 C1199(1.20); C1207(0.97); C1208(1.51); C1211(0.79)  LDD0543  [9]
 LDCM0227  AC110 HCT 116 C1199(0.77); C1207(0.78); C1211(0.85); C1232(0.69)  LDD0544  [9]
 LDCM0228  AC111 HCT 116 C1199(0.72); C1207(0.63); C1211(0.88); C1232(0.65)  LDD0545  [9]
 LDCM0229  AC112 HCT 116 C1199(0.78); C1207(0.68); C1211(0.73); C1232(0.60)  LDD0546  [9]
 LDCM0230  AC113 HCT 116 C1199(1.07); C1208(1.39); C1211(1.01); C1232(0.92)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C1199(1.19); C1208(1.30); C1211(0.84); C1232(0.93)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C1199(1.36); C1208(1.03); C1211(1.01); C1232(0.83)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C1199(1.15); C1208(1.07); C1211(0.79); C1232(0.80)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C1199(1.01); C1208(1.41); C1211(1.29); C1232(0.82)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C1199(1.11); C1208(1.95); C1211(0.79); C1232(0.96)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C1199(0.89); C1208(0.96); C1211(1.00); C1232(0.92)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C1199(1.11); C1207(1.34); C1208(1.18); C1211(0.74)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C1199(1.06); C1208(0.94); C1211(0.70); C1232(0.90)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C1199(0.99); C1208(1.03); C1211(1.14); C1232(1.13)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C1199(1.05); C1208(1.72); C1211(1.15); C1232(0.96)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C1199(0.96); C1208(1.16); C1211(1.09); C1232(1.16)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C1199(1.13); C1208(1.43); C1211(0.98); C1232(1.06)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C1199(1.28); C1208(1.58); C1211(1.34); C1232(0.96)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C1199(1.28); C1208(1.54); C1211(1.02); C1232(0.98)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C1199(1.77); C1208(1.14); C1211(0.98); C1232(0.93)  LDD0562  [9]
 LDCM0246  AC128 HCT 116 C1199(1.01); C1211(1.01); C1232(1.08); C1234(1.08)  LDD0563  [9]
 LDCM0247  AC129 HCT 116 C1199(1.05); C1211(1.05); C1232(1.03); C1234(1.03)  LDD0564  [9]
 LDCM0249  AC130 HCT 116 C1199(1.62); C1211(1.62); C1232(1.01); C1234(1.01)  LDD0566  [9]
 LDCM0250  AC131 HCT 116 C1199(1.15); C1211(1.15); C1232(1.08); C1234(1.08)  LDD0567  [9]
 LDCM0251  AC132 HCT 116 C1199(1.15); C1211(1.15); C1232(1.03); C1234(1.03)  LDD0568  [9]
 LDCM0252  AC133 HCT 116 C1199(2.14); C1211(2.14); C1232(1.07); C1234(1.07)  LDD0569  [9]
 LDCM0253  AC134 HCT 116 C1199(1.77); C1211(1.77); C1232(1.01); C1234(1.01)  LDD0570  [9]
 LDCM0254  AC135 HCT 116 C1199(1.53); C1211(1.53); C1232(1.02); C1234(1.02)  LDD0571  [9]
 LDCM0255  AC136 HCT 116 C1199(1.29); C1211(1.29); C1232(1.00); C1234(1.00)  LDD0572  [9]
 LDCM0256  AC137 HCT 116 C1199(1.66); C1211(1.66); C1232(1.06); C1234(1.06)  LDD0573  [9]
 LDCM0257  AC138 HCT 116 C1199(2.85); C1211(2.85); C1232(1.07); C1234(1.07)  LDD0574  [9]
 LDCM0258  AC139 HCT 116 C1199(1.35); C1211(1.35); C1232(0.99); C1234(0.99)  LDD0575  [9]
 LDCM0259  AC14 HCT 116 C1199(0.82); C1207(0.99); C1208(0.74); C1211(0.83)  LDD0576  [9]
 LDCM0260  AC140 HCT 116 C1199(1.77); C1211(1.77); C1232(1.03); C1234(1.03)  LDD0577  [9]
 LDCM0261  AC141 HCT 116 C1199(1.42); C1211(1.42); C1232(0.98); C1234(0.98)  LDD0578  [9]
 LDCM0262  AC142 HCT 116 C1199(1.68); C1211(1.68); C1232(1.18); C1234(1.18)  LDD0579  [9]
 LDCM0263  AC143 HCT 116 C1382(0.69); C1386(0.69); C826(0.74); C572(0.75)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C572(0.46); C826(0.70); C1234(0.73); C926(0.77)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C572(0.48); C1207(0.67); C1199(0.72); C926(0.73)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C572(0.49); C1382(0.70); C1386(0.71); C926(0.75)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C572(0.54); C926(0.74); C930(0.74); C1207(0.78)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C572(0.44); C1386(0.62); C1382(0.72); C1234(0.74)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C572(0.51); C1234(0.74); C1386(0.74); C1382(0.78)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C535(0.60); C1207(0.71); C1211(0.72); C1199(0.76)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C826(0.72); C572(0.73); C926(0.74); C930(0.74)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C572(0.55); C1234(0.82); C1386(0.82); C926(0.84)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C572(0.48); C1211(0.66); C1199(0.68); C1207(0.70)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C572(0.39); C1382(0.49); C1234(0.68); C926(0.68)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C1199(0.89); C1207(0.81); C1211(0.98); C1232(0.85)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C1199(0.81); C1207(0.80); C1211(0.82); C1232(0.78)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C1199(1.04); C1207(1.07); C1211(1.02); C1232(0.99)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C1199(0.93); C1207(0.80); C1211(1.07); C1232(0.94)  LDD2161  [9]
 LDCM0276  AC17 HCT 116 C1208(0.70); C535(0.81); C1234(0.82); C1232(0.84)  LDD0593  [9]
 LDCM0277  AC18 HCT 116 C535(0.62); C888(0.64); C1207(0.69); C572(0.70)  LDD0594  [9]
 LDCM0278  AC19 HCT 116 C535(0.70); C1207(0.72); C572(0.74); C1208(0.77)  LDD0595  [9]
 LDCM0279  AC2 HCT 116 C691(0.78); C708(0.78); C2539(0.79); C2546(0.79)  LDD0596  [9]
 LDCM0280  AC20 HCT 116 C535(0.68); C1208(0.69); C1234(0.80); C1232(0.82)  LDD0597  [9]
 LDCM0281  AC21 HCT 116 C1207(0.68); C1211(0.72); C1208(0.76); C535(0.79)  LDD0598  [9]
 LDCM0282  AC22 HCT 116 C1207(0.73); C826(0.75); C535(0.79); C1211(0.81)  LDD0599  [9]
 LDCM0283  AC23 HCT 116 C535(0.69); C1208(0.70); C1207(0.75); C1234(0.80)  LDD0600  [9]
 LDCM0284  AC24 HCT 116 C1207(0.69); C1208(0.71); C1211(0.81); C535(0.84)  LDD0601  [9]
 LDCM0285  AC25 HCT 116 C1199(0.67); C1211(0.67); C572(0.79); C888(0.81)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C926(0.68); C930(0.68); C1199(0.71); C1211(0.71)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C926(0.68); C930(0.68); C572(0.75); C1232(0.80)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C1199(0.64); C1211(0.64); C926(0.73); C930(0.73)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C926(0.64); C930(0.64); C883(0.71); C1232(0.73)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C2539(0.80); C2546(0.80); C691(0.84); C708(0.84)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C1199(0.55); C1211(0.55); C926(0.59); C930(0.59)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C1199(0.54); C1211(0.54); C926(0.72); C930(0.72)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C926(0.61); C930(0.61); C1199(0.63); C1211(0.63)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C572(0.66); C1232(0.70); C1234(0.70); C926(0.79)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C883(0.63); C888(0.68); C1232(0.68); C1234(0.68)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C730(0.80); C769(0.85); C2084(0.89); C826(0.92)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C2539(0.76); C2546(0.76); C769(0.79); C1382(0.84)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C730(0.79); C1382(0.80); C1386(0.80); C2314(0.83)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C2539(0.83); C2546(0.83); C769(0.83); C1382(0.90)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C2539(0.68); C2546(0.68); C888(0.82); C691(0.85)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C2539(0.58); C2546(0.58); C691(0.79); C708(0.79)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C769(0.72); C2539(0.82); C2546(0.82); C1382(0.84)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C769(0.59); C1382(0.59); C1386(0.59); C2314(0.81)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C769(0.68); C1382(0.74); C1386(0.74); C888(0.75)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C1382(0.61); C1386(0.61); C2539(0.64); C2546(0.64)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C769(0.57); C1382(0.63); C1386(0.63); C730(0.82)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C1382(0.58); C1386(0.58); C769(0.60); C2539(0.63)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C1386(0.73); C1382(0.74); C1234(0.85); C1232(0.90)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C1386(0.91); C926(0.91); C930(0.91); C1234(0.91)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C1386(0.77); C1382(0.81); C2539(0.91); C2546(0.91)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C1386(0.73); C1382(0.78); C769(0.80); C535(0.84)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C2539(0.72); C2546(0.72); C691(0.76); C708(0.76)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C1386(0.79); C826(0.79); C1382(0.80); C769(0.82)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C1291(0.75); C1386(0.76); C1382(0.78); C2084(0.91)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C1386(0.71); C1382(0.72); C826(0.85); C769(0.90)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C1382(0.83); C1386(0.86); C1234(0.93); C926(0.95)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C1386(0.85); C769(0.86); C883(0.88); C1382(0.88)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C1382(0.79); C1386(0.84); C572(0.91); C535(0.95)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C1386(0.70); C1382(0.72); C769(0.83); C1232(0.87)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C1232(0.72); C1234(0.72); C1382(0.83); C1386(0.83)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C1232(0.62); C1234(0.62); C1382(0.77); C1386(0.77)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C1232(0.77); C1234(0.77); C1382(0.83); C1386(0.83)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C1232(0.65); C1234(0.65); C1211(0.73); C926(0.80)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C1382(0.71); C1386(0.71); C691(0.75); C708(0.75)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C1232(0.68); C1234(0.68); C1382(0.68); C1386(0.68)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C1232(0.79); C1234(0.79); C535(0.85); C2084(0.89)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C535(0.75); C1382(0.75); C1386(0.75); C691(0.79)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C1382(0.82); C1386(0.82); C691(0.86); C708(0.86)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C1232(0.61); C1234(0.61); C1382(0.86); C1386(0.86)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C1232(0.58); C1234(0.58); C1382(0.82); C1386(0.82)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C1232(0.58); C1234(0.58); C535(0.67); C1199(0.76)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C1199(0.66); C1211(0.75); C769(0.81); C926(0.83)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C826(0.80); C769(0.82); C926(0.82); C930(0.82)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C1232(0.72); C1234(0.72); C1211(0.76); C535(0.82)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C769(0.58); C691(0.60); C708(0.60); C926(0.66)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C691(0.68); C708(0.68); C2314(0.83); C1291(0.89)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C769(0.75); C691(0.76); C708(0.76); C1291(0.89)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C769(0.67); C926(0.74); C930(0.74); C691(0.78)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C926(0.69); C930(0.69); C572(0.80); C769(0.83)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C691(0.66); C708(0.66); C769(0.67); C926(0.72)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C1942(0.85); C926(0.87); C930(0.87); C572(0.89)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C769(0.71); C926(0.76); C930(0.76); C1942(0.85)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C769(0.80); C926(0.82); C930(0.82); C2314(0.86)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C926(0.73); C930(0.73); C769(0.78); C691(0.89)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C1211(0.58); C1232(0.71); C1234(0.71); C888(0.76)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C826(0.78); C926(0.81); C930(0.81); C1291(0.93)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C1207(0.73); C691(0.77); C708(0.77); C769(0.82)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C572(0.68); C769(0.70); C691(0.71); C708(0.71)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C1232(0.67); C1234(0.67); C769(0.86); C1382(0.89)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C1232(0.75); C1234(0.75); C883(0.78); C888(0.78)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C1232(0.71); C1234(0.71); C883(0.76); C888(0.76)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C1232(0.73); C1234(0.73); C769(0.74); C691(0.86)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C769(0.77); C1382(0.84); C1386(0.84); C1942(0.89)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C1232(0.77); C1234(0.77); C1942(0.80); C769(0.81)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C1232(0.70); C1234(0.70); C769(0.80); C1382(0.82)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C769(0.73); C1942(0.89); C1382(0.93); C1386(0.93)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C1232(0.75); C1234(0.75); C691(0.86); C708(0.86)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C1232(0.77); C1234(0.77); C1942(0.81); C1382(0.90)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C1942(0.78); C1232(0.79); C1234(0.79); C769(0.81)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C883(0.74); C888(0.74); C1232(0.82); C1234(0.82)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C769(0.81); C1382(0.83); C1386(0.83); C1232(0.84)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C1232(0.78); C1234(0.78); C883(0.86); C888(0.86)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C769(0.67); C1232(0.68); C1234(0.68); C1382(0.80)  LDD0681  [9]
 LDCM0365  AC98 HCT 116 C2539(0.24); C2546(0.24); C926(0.28); C930(0.28)  LDD0682  [9]
 LDCM0366  AC99 HCT 116 C926(0.51); C930(0.51); C769(0.62); C691(0.64)  LDD0683  [9]
 LDCM0248  AKOS034007472 HCT 116 C1199(1.17); C1207(1.27); C1208(1.28); C1211(0.86)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C1232(0.77); C1234(0.77); C691(0.79); C708(0.79)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C2539(0.49); C2546(0.49); C535(0.65); C1232(0.67)  LDD0592  [9]
 LDCM0020  ARS-1620 HCC44 C883(0.84); C888(0.84)  LDD0078  [9]
 LDCM0151  AZ-11 HeLa 10.00  LDD2154  [6]
 LDCM0108  Chloroacetamide HeLa C739(0.00); C730(0.00); C769(0.00); C1382(0.00)  LDD0222  [8]
 LDCM0632  CL-Sc Hep-G2 C2314(20.00); C1942(20.00); C2267(2.84); C2094(1.47)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C826(0.83); C883(0.96); C888(0.96); C926(1.01)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C826(0.78); C572(0.89); C2314(0.96); C769(0.96)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C2539(0.58); C2546(0.58); C691(0.82); C708(0.82)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C2539(0.65); C2546(0.65); C1232(0.76); C1234(0.76)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C535(0.67); C1232(0.78); C1234(0.78); C2539(0.86)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C535(0.72); C2314(0.80); C1232(0.80); C1234(0.80)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C1232(0.76); C1234(0.76); C1207(0.77); C2314(0.79)  LDD0690  [9]
 LDCM0374  CL105 HCT 116 C572(0.69); C1207(0.71); C1208(0.78); C1234(0.79)  LDD0691  [9]
 LDCM0375  CL106 HCT 116 C572(0.64); C1207(0.68); C1208(0.68); C888(0.72)  LDD0692  [9]
 LDCM0376  CL107 HCT 116 C1234(0.69); C1232(0.73); C572(0.73); C888(0.73)  LDD0693  [9]
 LDCM0377  CL108 HCT 116 C1207(0.65); C572(0.72); C535(0.74); C1208(0.74)  LDD0694  [9]
 LDCM0378  CL109 HCT 116 C572(0.69); C1207(0.70); C1234(0.74); C535(0.75)  LDD0695  [9]
 LDCM0379  CL11 HCT 116 C826(0.56); C572(0.82); C926(0.84); C930(0.84)  LDD0696  [9]
 LDCM0380  CL110 HCT 116 C572(0.63); C1208(0.66); C535(0.68); C1207(0.74)  LDD0697  [9]
 LDCM0381  CL111 HCT 116 C535(0.58); C1208(0.68); C888(0.71); C572(0.71)  LDD0698  [9]
 LDCM0382  CL112 HCT 116 C926(0.76); C930(0.76); C535(0.79); C883(0.81)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C926(0.64); C930(0.64); C883(0.64); C888(0.66)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C926(0.62); C930(0.62); C1232(0.70); C1234(0.70)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C926(0.62); C930(0.62); C883(0.68); C888(0.72)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C1232(0.72); C1234(0.72); C926(0.79); C930(0.79)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C2539(0.57); C2546(0.57); C769(0.70); C826(0.86)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C2539(0.70); C2546(0.70); C883(0.85); C888(0.87)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C888(0.76); C769(0.79); C1382(0.81); C1386(0.81)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C826(0.70); C926(0.87); C930(0.87); C572(0.87)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C1382(0.66); C1386(0.66); C769(0.70); C888(0.82)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C2539(0.45); C2546(0.45); C1211(0.69); C1199(0.70)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C1386(0.86); C1382(0.87); C926(0.91); C930(0.91)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C1382(0.88); C1386(0.90); C535(0.91); C1207(0.93)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C1386(0.68); C1382(0.70); C926(0.84); C930(0.84)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C1232(0.81); C1234(0.81); C691(0.81); C708(0.81)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C1232(0.70); C1234(0.70); C535(0.83); C1382(0.88)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C1199(0.58); C1211(0.58); C1232(0.73); C1234(0.73)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C1232(0.70); C1234(0.70); C1382(0.81); C1386(0.81)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C1208(0.80); C1211(0.80); C883(0.80); C888(0.80)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C826(0.83); C926(0.92); C930(0.92); C2314(0.94)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C926(0.87); C930(0.87); C826(0.89); C1208(0.96)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C1232(0.79); C1234(0.79); C883(0.86); C888(0.86)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C1382(0.65); C1386(0.65); C769(0.66); C1942(0.85)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C888(0.77); C883(0.84); C1232(0.84); C1234(0.84)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C1382(0.74); C1386(0.74); C1232(0.88); C1234(0.88)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C1208(0.96); C1211(0.96); C826(0.98); C926(1.01)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C1382(0.56); C1386(0.56); C1199(0.71); C1211(0.71)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C1199(0.62); C1211(0.62); C769(0.78); C1232(0.81)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C1199(0.64); C1211(0.64); C769(0.72); C1382(0.74)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C1199(0.68); C1211(0.68); C769(0.78); C883(0.81)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C1199(0.69); C1211(0.69); C1232(0.77); C1234(0.77)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C1199(0.77); C1211(0.77); C1232(0.81); C1234(0.81)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C1199(0.63); C1211(0.63); C1232(0.81); C1234(0.81)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C1199(0.92); C1211(0.92); C1232(0.87); C1234(0.87)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C1199(0.63); C1211(0.63); C1232(0.74); C1234(0.74)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C1199(0.92); C1211(0.92); C1232(0.76); C1234(0.76)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C1208(0.91); C1211(0.91); C1232(1.29); C1234(1.29)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C1199(1.08); C1211(1.08); C1232(0.87); C1234(0.87)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C1199(0.84); C1211(0.84); C1232(0.92); C1234(0.92)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C1199(0.82); C1211(0.82); C1232(0.87); C1234(0.87)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C1199(0.95); C1211(0.95); C1232(0.85); C1234(0.85)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C1199(1.08); C1211(1.08); C1232(0.76); C1234(0.76)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C1199(0.94); C1211(0.94); C1232(0.83); C1234(0.83)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C1199(0.71); C1211(0.71); C1232(0.84); C1234(0.84)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C1199(0.95); C1211(0.95); C1232(0.85); C1234(0.85)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C1199(0.81); C1211(0.81); C1232(0.92); C1234(0.92)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C1208(1.01); C1211(1.01); C1232(1.19); C1234(1.19)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C1199(1.31); C1211(1.31); C1232(0.93); C1234(0.93)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C1199(0.98); C1211(0.98); C1232(0.82); C1234(0.82)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C1199(1.03); C1211(1.03); C1232(0.85); C1234(0.85)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C1199(0.61); C1211(0.61); C1232(0.77); C1234(0.77)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C1199(0.64); C1211(0.64); C1232(0.82); C1234(0.82)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C1199(1.02); C1211(1.02); C1232(0.79); C1234(0.79)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C1199(1.15); C1207(1.15); C1232(1.13); C1234(1.13)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C1199(1.08); C1207(1.08); C1232(1.14); C1234(1.14)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C1199(1.50); C1207(1.50); C1232(1.12); C1234(1.12)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C1199(1.18); C1207(1.18); C1232(1.06); C1234(1.06)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C1208(0.95); C1211(0.95); C1232(1.16); C1234(1.16)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C1199(1.28); C1207(1.28); C1232(1.12); C1234(1.12)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C1199(1.14); C1207(1.14); C1232(1.15); C1234(1.15)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C1199(1.47); C1207(1.47); C1232(1.16); C1234(1.16)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C1199(1.82); C1207(1.82); C1232(1.09); C1234(1.09)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C1199(1.18); C1207(1.18); C1232(1.30); C1234(1.30)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C1199(1.12); C1207(1.12); C1232(1.28); C1234(1.28)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C1199(1.28); C1207(1.28); C1232(1.07); C1234(1.07)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C1199(1.31); C1207(1.31); C1232(1.15); C1234(1.15)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C1199(1.16); C1207(1.16); C1232(1.18); C1234(1.18)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C1199(1.04); C1207(1.04); C1232(1.12); C1234(1.12)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C1208(0.98); C1211(0.98); C1232(1.06); C1234(1.06)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C1199(1.19); C1207(1.19); C1232(1.04); C1234(1.04)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C1232(0.92); C1234(0.86); C1291(1.02); C2084(1.19)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C1232(0.87); C1234(0.93); C1291(1.08); C2084(1.23)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C1232(0.75); C1234(0.83); C1291(1.16); C2084(1.32)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C1232(0.91); C1234(0.89); C1291(1.24); C2084(1.46)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C1232(0.91); C1234(0.92); C1291(1.18); C2084(1.26)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C1232(0.85); C1234(0.83); C1291(1.49); C2084(1.21)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C1232(0.97); C1234(0.98); C1291(1.38); C2084(1.41)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C1232(0.97); C1234(0.95); C1291(1.25); C2084(1.17)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C1232(0.73); C1234(0.73); C1291(0.98); C2084(1.53)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C1208(1.06); C1211(1.06); C1232(1.15); C1234(1.15)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C1232(0.81); C1234(0.80); C1291(1.05); C2084(1.06)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C1232(0.79); C1234(0.82); C1291(1.18); C2084(1.24)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C1232(0.79); C1234(0.84); C1291(1.09); C2084(1.31)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C1232(0.85); C1234(0.85); C1291(1.28); C2084(1.18)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C1232(0.83); C1234(0.88); C1291(1.24); C2084(1.29)  LDD0784  [9]
 LDCM0469  CL76 HCT 116 C1199(1.18); C1211(1.18); C1232(1.05); C1234(1.05)  LDD0786  [9]
 LDCM0470  CL77 HCT 116 C1199(1.02); C1211(1.02); C1232(1.11); C1234(1.11)  LDD0787  [9]
 LDCM0471  CL78 HCT 116 C1199(1.38); C1211(1.38); C1232(1.04); C1234(1.04)  LDD0788  [9]
 LDCM0472  CL79 HCT 116 C1199(1.39); C1211(1.39); C1232(1.01); C1234(1.01)  LDD0789  [9]
 LDCM0473  CL8 HCT 116 C1208(0.95); C1211(0.95); C1232(1.10); C1234(1.10)  LDD0790  [9]
 LDCM0474  CL80 HCT 116 C1199(1.58); C1211(1.58); C1232(1.08); C1234(1.08)  LDD0791  [9]
 LDCM0475  CL81 HCT 116 C1199(1.12); C1211(1.12); C1232(0.99); C1234(0.99)  LDD0792  [9]
 LDCM0476  CL82 HCT 116 C1199(1.33); C1211(1.33); C1232(1.06); C1234(1.06)  LDD0793  [9]
 LDCM0477  CL83 HCT 116 C1199(1.33); C1211(1.33); C1232(1.13); C1234(1.13)  LDD0794  [9]
 LDCM0478  CL84 HCT 116 C1199(1.17); C1211(1.17); C1232(0.98); C1234(0.98)  LDD0795  [9]
 LDCM0479  CL85 HCT 116 C1199(1.24); C1211(1.24); C1232(1.03); C1234(1.03)  LDD0796  [9]
 LDCM0480  CL86 HCT 116 C1199(1.38); C1211(1.38); C1232(1.06); C1234(1.06)  LDD0797  [9]
 LDCM0481  CL87 HCT 116 C1199(1.22); C1211(1.22); C1232(1.12); C1234(1.12)  LDD0798  [9]
 LDCM0482  CL88 HCT 116 C1199(1.25); C1211(1.25); C1232(1.21); C1234(1.21)  LDD0799  [9]
 LDCM0483  CL89 HCT 116 C1199(1.04); C1211(1.04); C1232(1.07); C1234(1.07)  LDD0800  [9]
 LDCM0484  CL9 HCT 116 C1208(1.26); C1211(1.26); C1232(1.11); C1234(1.11)  LDD0801  [9]
 LDCM0485  CL90 HCT 116 C1199(1.60); C1211(1.60); C1232(1.08); C1234(1.08)  LDD0802  [9]
 LDCM0486  CL91 HCT 116 C1199(1.44); C1211(1.44); C1232(0.93); C1234(0.93)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C1199(1.00); C1211(1.00); C1232(0.99); C1234(0.99)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C1199(1.34); C1211(1.34); C1232(1.13); C1234(1.13)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C1199(1.08); C1211(1.08); C1232(1.06); C1234(1.06)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C1199(0.83); C1211(0.83); C1232(0.95); C1234(0.95)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C1199(0.85); C1211(0.85); C1232(0.94); C1234(0.94)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C1199(0.99); C1211(0.99); C1232(0.89); C1234(0.89)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C1199(1.08); C1211(1.08); C1232(0.89); C1234(0.89)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C1199(1.29); C1211(1.29); C1232(0.94); C1234(0.94)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C2267(0.98); C730(0.88); C2084(0.96); C2094(0.77)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C739(1.66); C2267(1.53); C730(1.45); C2314(1.20)  LDD1702  [5]
 LDCM0625  F8 Ramos C730(1.24); C2267(1.51); C2314(0.98)  LDD2187  [21]
 LDCM0572  Fragment10 MDA-MB-231 C2267(1.85)  LDD1389  [22]
 LDCM0573  Fragment11 Ramos C2267(1.47)  LDD1392  [22]
 LDCM0574  Fragment12 Ramos C730(0.77); C2267(2.27)  LDD2191  [21]
 LDCM0575  Fragment13 Ramos C2267(0.81)  LDD1396  [22]
 LDCM0576  Fragment14 Ramos C2267(1.49)  LDD1398  [22]
 LDCM0577  Fragment15 Ramos C2267(1.40)  LDD1400  [22]
 LDCM0579  Fragment20 MDA-MB-231 C2267(0.88)  LDD1402  [22]
 LDCM0580  Fragment21 Ramos C730(0.91); C2267(1.15); C2084(1.23)  LDD2195  [21]
 LDCM0581  Fragment22 Ramos C2267(1.10)  LDD1407  [22]
 LDCM0582  Fragment23 Ramos C2267(1.30)  LDD1409  [22]
 LDCM0583  Fragment24 Ramos C2267(1.07)  LDD1410  [22]
 LDCM0585  Fragment26 Ramos C2267(0.93)  LDD1412  [22]
 LDCM0578  Fragment27 MDA-MB-231 C2267(0.80)  LDD1401  [22]
 LDCM0586  Fragment28 MDA-MB-231 C2267(1.06)  LDD1415  [22]
 LDCM0588  Fragment30 MDA-MB-231 C2267(0.86)  LDD1419  [22]
 LDCM0589  Fragment31 Ramos C730(0.95); C2267(1.47)  LDD2200  [21]
 LDCM0590  Fragment32 MDA-MB-231 C2267(1.50)  LDD1423  [22]
 LDCM0468  Fragment33 HCT 116 C1232(0.88); C1234(0.85); C1291(1.15); C2084(1.34)  LDD0785  [9]
 LDCM0596  Fragment38 Ramos C2267(1.67)  LDD1434  [22]
 LDCM0566  Fragment4 Ramos C2267(1.72)  LDD1379  [22]
 LDCM0600  Fragment42 Ramos C2267(0.81)  LDD1440  [22]
 LDCM0602  Fragment44 MDA-MB-231 C2267(0.72)  LDD1443  [22]
 LDCM0608  Fragment50 MDA-MB-231 C2267(1.56)  LDD1449  [22]
 LDCM0427  Fragment51 HCT 116 C1199(0.94); C1211(0.94); C1232(0.93); C1234(0.93)  LDD0744  [9]
 LDCM0610  Fragment52 Ramos C2267(1.07)  LDD1453  [22]
 LDCM0611  Fragment53 Ramos C2267(0.94)  LDD1455  [22]
 LDCM0614  Fragment56 MDA-MB-231 C2267(1.11)  LDD1458  [22]
 LDCM0569  Fragment7 Ramos C730(1.04); C2267(2.43)  LDD2186  [21]
 LDCM0570  Fragment8 Ramos C2267(1.33)  LDD1386  [22]
 LDCM0571  Fragment9 MDA-MB-231 C2267(0.72)  LDD1387  [22]
 LDCM0107  IAA HeLa N.A.  LDD0221  [8]
 LDCM0022  KB02 HCT 116 C2084(2.81); C2314(2.41); C730(1.68)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C2084(1.79); C2314(1.53); C730(1.43)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C2084(2.17); C2314(2.13); C730(1.53)  LDD0082  [9]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C739(0.88)  LDD2102  [5]
 LDCM0109  NEM HeLa H2142(0.00); H1873(0.00); H460(0.00)  LDD0227  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C739(1.20)  LDD2090  [5]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C739(0.72)  LDD2092  [5]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C739(1.17)  LDD2093  [5]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C2267(1.01)  LDD2094  [5]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C739(1.03)  LDD2096  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C739(0.78)  LDD2098  [5]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C739(0.94); C2094(0.99)  LDD2099  [5]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C739(0.71)  LDD2100  [5]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C739(0.84)  LDD2104  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C739(1.51)  LDD2105  [5]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C739(0.63)  LDD2106  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C739(0.89); C2314(1.06)  LDD2107  [5]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C739(0.67)  LDD2108  [5]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C739(0.76); C2314(0.54)  LDD2109  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C739(0.90)  LDD2111  [5]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C739(0.76)  LDD2114  [5]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C739(0.95)  LDD2116  [5]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C739(1.06)  LDD2118  [5]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C739(1.05)  LDD2122  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C739(1.62); C1291(1.21)  LDD2123  [5]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C739(0.98)  LDD2124  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2314(0.72)  LDD2125  [5]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C739(1.12); C2314(1.74)  LDD2126  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C739(1.00); C2314(0.86)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C739(0.85)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C739(0.93)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C2314(0.71)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C739(1.08); C2314(0.82); C1291(1.12)  LDD2137  [5]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C739(1.26)  LDD1700  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C739(0.80)  LDD2140  [5]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C739(0.68)  LDD2141  [5]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C739(1.85)  LDD2151  [5]
 LDCM0021  THZ1 HCT 116 C730(1.11); C2084(1.12); C691(1.10); C708(1.10)  LDD2173  [9]
 LDCM0112  W16 Hep-G2 C2314(0.52)  LDD0239  [17]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glycogen synthase kinase-3 beta (GSK3B) CMGC Ser/Thr protein kinase family P49841
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Catenin beta-1 (CTNNB1) Beta-catenin family P35222
Polyadenylate-binding protein-interacting protein 2 (PAIP2) PAIP2 family Q9BPZ3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
7 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
8 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
11 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
12 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
17 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.