Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment8  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 101 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 20.0
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 20.0
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 20.0
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 20.0
 LDTP14159  Ubiquitin carboxyl-terminal hydrolase 16 (USP16) C205 20.0
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 19.8
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 16.5
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 14.7
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 13.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 12.6
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 9.4
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 8.5
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 8.5
 LDTP05373  Procollagen-lysine,2-oxoglutarate 5-dioxygenase 1 (PLOD1) C680 5.4
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 3.8
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 3.7
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 3.2
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 3.2
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 2.7
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 2.5
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 2.5
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 2.4
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 2.3
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 2.3
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 2.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 2.2
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 2.1
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 2.1
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 2.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 2.1
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 2.1
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 2.0
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 2.0
 LDTP07098  Probable ATP-dependent RNA helicase DDX59 (DDX59) C414 2.0
 LDTP13147  Cathepsin Z (CTSZ) C92 2.0
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 1.9
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 1.8
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.7
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.6
 LDTP05289  AMP deaminase 2 (AMPD2) C107 1.6
 LDTP02502  Thioredoxin (TXN) C32 1.6
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 1.5
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 1.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 1.5
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.5
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 1.5
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.5
 LDTP05992  Bleomycin hydrolase (BLMH) C73 1.5
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C179 1.5
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 1.5
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.4
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.4
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.4
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.4
 LDTP06211  Caspase-8 (CASP8) C360 1.4
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.4
 LDTP01495  E3 ubiquitin-protein ligase UBR5 (UBR5) C2267 1.3
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.3
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 1.3
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.3
 LDTP02672  Elongation factor 2 (EEF2) C41 1.3
 LDTP04689  Adenosine kinase (ADK) C353 1.2
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 1.2
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.2
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 1.2
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.2
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.2
 LDTP04424  Galactokinase (GALK1) C182 1.2
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.2
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 1.2
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.2
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.1
 LDTP10929  Cell cycle checkpoint control protein RAD9A (RAD9A) C114 1.1
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.1
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 1.1
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.0
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.0
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.0
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.0
 LDTP15306  Transmembrane protease serine 12 (TMPRSS12) C64 1.0
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.0
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP02672  Elongation factor 2 (EEF2) C136 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 0.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.9
 LDTP11340  Cyclin-dependent kinase 19 (CDK19) C349 0.9
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 0.9
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 0.9
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C100 0.9
 LDTP04374  Dynamin-2 (DNM2) C27 0.9
 LDTP02733  Pyruvate kinase PKM (PKM) C423 0.8
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.8
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.7
 LDTP04251  Elongation factor Tu, mitochondrial (TUFM) C147 0.7
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.5
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 0.4
Transporter and channel
Click to Show/Hide to Show 13 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 4.3
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 3.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 2.6
 LDTP04801  Gasdermin-D (GSDMD) C268 2.6
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 2.4
 LDTP04707  Protein SEC13 homolog (SEC13) C187 1.9
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.8
 LDTP00501  Exportin-1 (XPO1) C34 1.5
 LDTP01574  Importin-7 (IPO7) C757 1.3
 LDTP03327  ATP synthase subunit alpha, mitochondrial (ATP5F1A) C294 1.3
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.2
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 1.2
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 0.7
Transcription factor
Click to Show/Hide to Show 6 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 3.7
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 3.1
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 2.3
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.7
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.3
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.0
Other
Click to Show/Hide to Show 77 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 20.0
 LDTP04092  Crk-like protein (CRKL) C249 15.4
 LDTP14195  FH1/FH2 domain-containing protein 1 (FHOD1) C502 5.3
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 3.3
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 3.0
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 2.6
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 2.4
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 2.3
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 2.2
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 2.0
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 2.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 2.0
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 1.9
 LDTP02511  cAMP-dependent protein kinase type I-alpha regulatory subunit (PRKAR1A) C18 1.8
 LDTP13591  A-kinase anchor protein 8-like (AKAP8L) C211 1.8
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.8
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.8
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.7
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 1.7
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.7
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.6
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 1.6
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.6
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 1.6
 LDTP10864  Calponin-2 (CNN2) C215 1.6
 LDTP11718  Cleavage stimulation factor subunit 2 tau variant (CSTF2T) C150 1.5
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.5
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.5
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.5
 LDTP05867  Treacle protein (TCOF1) C1298 1.5
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 1.5
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.5
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 1.4
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.4
 LDTP13837  Trafficking protein particle complex subunit 4 (TRAPPC4) C195 1.4
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.4
 LDTP05867  Treacle protein (TCOF1) C38 1.4
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.4
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.4
 LDTP10864  Calponin-2 (CNN2) C164 1.3
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.3
 LDTP03860  Stress-70 protein, mitochondrial (HSPA9) C317 1.3
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.3
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 1.3
 LDTP02205  Tubulin beta chain (TUBB) C354 1.3
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 1.3
 LDTP01532  ZW10 interactor (ZWINT) C54 1.3
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.2
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.2
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.2
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.2
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.2
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.2
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 1.2
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 1.1
 LDTP02205  Tubulin beta chain (TUBB) C239 1.1
 LDTP13580  Coronin-1C (CORO1C) C420 1.1
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 1.1
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.1
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.1
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.0
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.0
 LDTP04517  Transcription initiation factor IIA subunit 2 (GTF2A2) C68 1.0
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 1.0
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 1.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.0
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.0
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.0
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 0.9
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) C35 0.9
 LDTP03244  Cofilin-1 (CFL1) C80 0.9
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 0.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.8
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.8
 LDTP04117  Ras GTPase-activating-like protein IQGAP1 (IQGAP1) C781 0.5

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.