Details of the Target

General Information of Target

Target ID LDTP11718
Target Name Cleavage stimulation factor subunit 2 tau variant (CSTF2T)
Gene Name CSTF2T
Gene ID 23283
Synonyms
KIAA0689; Cleavage stimulation factor subunit 2 tau variant; CF-1 64 kDa subunit tau variant; Cleavage stimulation factor 64 kDa subunit tau variant; CSTF 64 kDa subunit tau variant; TauCstF-64
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEEDTDYRIRFSSLCFFNDHVGFHGTIKSSPSDFIVIEIDEQGQLVNKTIDEPIFKISEI
QLEPNNFPKKPKLDLQNLSLEDGRNQEVHTLIKYTDGDQNHQSGSEKEDTIVDGTSKCEE
KADVLSSFLDEKTHELLNNFACDVREKWLSKTELIGLPPEFSIGRILDKNQRASLHSAIR
QKFPFLVTVGKNSEIVVKPNLEYKELCHLVSEEEAFDFFKYLDAKKENSKFTFKPDTNKD
HRKAVHHFVNKKFGNLVETKSFSKMNCSAGNPNVVVTVRFREKAHKRGKRPLSECQEGKV
IYTAFTLRKENLEMFEAIGFLAIKLGVIPSDFSYAGLKDKKAITYQAMVVRKVTPERLKN
IEKEIEKKRMNVFNIRSVDDSLRLGQLKGNHFDIVIRNLKKQINDSANLRERIMEAIENV
KKKGFVNYYGPQRFGKGRKVHTDQIGLALLKNEMMKAIKLFLTPEDLDDPVNRAKKYFLQ
TEDAKGTLSLMPEFKVRERALLEALHRFGMTEEGCIQAWFSLPHSMRIFYVHAYTSKIWN
EAVSYRLETYGARVVQGDLVCLDEDIDDENFPNSKIHLVTEEEGSANMYAIHQVVLPVLG
YNIQYPKNKVGQWYHDILSRDGLQTCRFKVPTLKLNIPGCYRQILKHPCNLSYQLMEDHD
IDVKTKGSHIDETALSLLISFDLDASCYATVCLKEIMKHDV
Target Bioclass
Other
Subcellular location
Nucleus
Function May play a significant role in AAUAAA-independent mRNA polyadenylation in germ cells. Directly involved in the binding to pre-mRNAs.
Uniprot ID
Q9H0L4
Ensemble ID
ENST00000331173.6
HGNC ID
HGNC:17086

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 27 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.63  LDD0402  [1]
TH211
 Probe Info  		Y25(11.44)  LDD0257  [2]
Probe 1
 Probe Info  		Y115(9.47)  LDD3495  [3]
AHL-Pu-1
 Probe Info  		C222(2.27)  LDD0168  [4]
DBIA
 Probe Info  		C441(4.98); C150(149.39)  LDD0209  [5]
HHS-475
 Probe Info  		Y59(0.75)  LDD0264  [6]
W1
 Probe Info  		C441(0.67)  LDD0239  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		C62(0.00); C150(0.00)  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [8]
BTD
 Probe Info  		N.A.  LDD0004  [9]
IPM
 Probe Info  		C150(0.00); C222(0.00)  LDD0025  [10]
JW-RF-010
 Probe Info  		C150(0.00); C222(0.00)  LDD0026  [10]
NAIA_4
 Probe Info  		N.A.  LDD2226  [11]
TFBX
 Probe Info  		C222(0.00); C150(0.00)  LDD0027  [10]
WYneN
 Probe Info  		N.A.  LDD0021  [9]
Compound 10
 Probe Info  		C150(0.00); C441(0.00)  LDD2216  [12]
Compound 11
 Probe Info  		N.A.  LDD2213  [12]
STPyne
 Probe Info  		K194(0.00); K606(0.00)  LDD0009  [9]
VSF
 Probe Info  		C441(0.00); C222(0.00)  LDD0007  [9]
Phosphinate-6
 Probe Info  		C222(0.00); C441(0.00); C150(0.00)  LDD0018  [13]
Acrolein
 Probe Info  		C150(0.00); C441(0.00)  LDD0217  [14]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [14]
Methacrolein
 Probe Info  		N.A.  LDD0218  [14]
AOyne
 Probe Info  		13.60  LDD0443  [15]
NAIA_5
 Probe Info  		N.A.  LDD2223  [11]
HHS-465
 Probe Info  		N.A.  LDD2240  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C150(0.97)  LDD2142  [17]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C150(0.83)  LDD2112  [17]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C150(0.64)  LDD2095  [17]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C150(1.01)  LDD2130  [17]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C150(1.04)  LDD2117  [17]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C150(0.96)  LDD2152  [17]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C150(0.62)  LDD2132  [17]
 LDCM0025  4SU-RNA HEK-293T C222(2.27)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C441(5.14)  LDD0171  [4]
 LDCM0214  AC1 HCT 116 C150(1.13); C62(1.05)  LDD0531  [18]
 LDCM0215  AC10 HCT 116 C150(1.18); C62(0.65)  LDD0532  [18]
 LDCM0216  AC100 HCT 116 C150(0.89); C62(0.51)  LDD0533  [18]
 LDCM0217  AC101 HCT 116 C150(1.05); C62(0.85)  LDD0534  [18]
 LDCM0218  AC102 HCT 116 C150(1.05); C62(0.74)  LDD0535  [18]
 LDCM0219  AC103 HCT 116 C150(1.30); C62(0.65)  LDD0536  [18]
 LDCM0220  AC104 HCT 116 C150(1.14); C62(0.81)  LDD0537  [18]
 LDCM0221  AC105 HCT 116 C150(1.06); C62(0.79)  LDD0538  [18]
 LDCM0222  AC106 HCT 116 C150(1.24); C62(0.91)  LDD0539  [18]
 LDCM0223  AC107 HCT 116 C150(1.09); C62(0.87)  LDD0540  [18]
 LDCM0224  AC108 HCT 116 C150(1.25); C62(0.74)  LDD0541  [18]
 LDCM0225  AC109 HCT 116 C150(1.26); C62(0.98)  LDD0542  [18]
 LDCM0226  AC11 HCT 116 C150(1.14); C62(0.57)  LDD0543  [18]
 LDCM0227  AC110 HCT 116 C150(1.24); C62(0.57)  LDD0544  [18]
 LDCM0228  AC111 HCT 116 C150(1.28); C62(0.62)  LDD0545  [18]
 LDCM0229  AC112 HCT 116 C150(1.13); C62(0.69)  LDD0546  [18]
 LDCM0230  AC113 HCT 116 C150(0.99); C222(1.24); C62(1.04)  LDD0547  [18]
 LDCM0231  AC114 HCT 116 C150(1.20); C222(1.36); C62(1.31)  LDD0548  [18]
 LDCM0232  AC115 HCT 116 C150(1.11); C222(0.97); C62(1.26)  LDD0549  [18]
 LDCM0233  AC116 HCT 116 C150(1.23); C222(1.43); C62(1.10)  LDD0550  [18]
 LDCM0234  AC117 HCT 116 C150(1.02); C222(0.95); C62(1.33)  LDD0551  [18]
 LDCM0235  AC118 HCT 116 C150(1.06); C222(1.27); C62(1.46)  LDD0552  [18]
 LDCM0236  AC119 HCT 116 C150(1.13); C222(1.19); C62(1.29)  LDD0553  [18]
 LDCM0237  AC12 HCT 116 C150(1.04); C62(0.77)  LDD0554  [18]
 LDCM0238  AC120 HCT 116 C150(1.21); C222(1.29); C62(1.44)  LDD0555  [18]
 LDCM0239  AC121 HCT 116 C150(1.08); C222(0.92); C62(1.36)  LDD0556  [18]
 LDCM0240  AC122 HCT 116 C150(1.11); C222(1.33); C62(1.47)  LDD0557  [18]
 LDCM0241  AC123 HCT 116 C150(1.20); C222(0.88); C62(1.15)  LDD0558  [18]
 LDCM0242  AC124 HCT 116 C150(1.21); C222(0.93); C62(1.28)  LDD0559  [18]
 LDCM0243  AC125 HCT 116 C150(1.41); C222(1.06); C62(1.42)  LDD0560  [18]
 LDCM0244  AC126 HCT 116 C150(1.40); C222(1.08); C62(1.30)  LDD0561  [18]
 LDCM0245  AC127 HCT 116 C150(1.29); C222(0.94); C62(1.45)  LDD0562  [18]
 LDCM0246  AC128 HCT 116 C150(1.41); C222(1.00); C62(1.37)  LDD0563  [18]
 LDCM0247  AC129 HCT 116 C150(1.19); C222(0.77); C62(1.33)  LDD0564  [18]
 LDCM0249  AC130 HCT 116 C150(1.15); C222(1.03); C62(0.96)  LDD0566  [18]
 LDCM0250  AC131 HCT 116 C150(0.93); C222(0.89); C62(0.86)  LDD0567  [18]
 LDCM0251  AC132 HCT 116 C150(1.09); C222(0.80); C62(0.77)  LDD0568  [18]
 LDCM0252  AC133 HCT 116 C150(1.18); C222(0.81); C62(0.73)  LDD0569  [18]
 LDCM0253  AC134 HCT 116 C150(1.18); C222(1.05); C62(0.91)  LDD0570  [18]
 LDCM0254  AC135 HCT 116 C150(1.21); C222(1.02); C62(0.73)  LDD0571  [18]
 LDCM0255  AC136 HCT 116 C150(1.38); C222(1.04); C62(0.76)  LDD0572  [18]
 LDCM0256  AC137 HCT 116 C150(1.04); C222(0.79); C62(0.69)  LDD0573  [18]
 LDCM0257  AC138 HCT 116 C150(1.20); C222(1.08); C62(0.74)  LDD0574  [18]
 LDCM0258  AC139 HCT 116 C150(1.28); C222(0.85); C62(0.75)  LDD0575  [18]
 LDCM0259  AC14 HCT 116 C150(1.13); C62(0.69)  LDD0576  [18]
 LDCM0260  AC140 HCT 116 C150(1.28); C222(1.12); C62(0.64)  LDD0577  [18]
 LDCM0261  AC141 HCT 116 C150(1.22); C222(1.21); C62(0.77)  LDD0578  [18]
 LDCM0262  AC142 HCT 116 C150(0.98); C222(0.72); C62(0.63)  LDD0579  [18]
 LDCM0263  AC143 HCT 116 C150(1.23); C222(1.03); C62(0.60)  LDD0580  [18]
 LDCM0264  AC144 HCT 116 C62(0.31); C222(1.23); C150(1.53)  LDD0581  [18]
 LDCM0265  AC145 HCT 116 C62(0.72); C222(1.04); C150(1.25)  LDD0582  [18]
 LDCM0266  AC146 HCT 116 C62(0.38); C222(1.40); C150(1.67)  LDD0583  [18]
 LDCM0267  AC147 HCT 116 C62(0.32); C222(1.21); C150(1.97)  LDD0584  [18]
 LDCM0268  AC148 HCT 116 C62(0.23); C222(2.20); C150(2.40)  LDD0585  [18]
 LDCM0269  AC149 HCT 116 C62(0.33); C222(1.60); C150(1.81)  LDD0586  [18]
 LDCM0270  AC15 HCT 116 C62(0.72); C150(1.30)  LDD0587  [18]
 LDCM0271  AC150 HCT 116 C62(0.81); C222(0.98); C150(1.33)  LDD0588  [18]
 LDCM0272  AC151 HCT 116 C62(0.72); C222(1.05); C150(1.19)  LDD0589  [18]
 LDCM0273  AC152 HCT 116 C62(0.30); C222(1.53); C150(1.92)  LDD0590  [18]
 LDCM0274  AC153 HCT 116 C62(0.22); C222(2.12); C150(2.90)  LDD0591  [18]
 LDCM0621  AC154 HCT 116 C150(1.79); C222(1.47); C62(0.39)  LDD2158  [18]
 LDCM0622  AC155 HCT 116 C150(1.55); C222(1.18); C62(0.43)  LDD2159  [18]
 LDCM0623  AC156 HCT 116 C150(1.30); C222(0.85); C62(0.66)  LDD2160  [18]
 LDCM0624  AC157 HCT 116 C150(1.21); C222(0.95); C62(0.52)  LDD2161  [18]
 LDCM0276  AC17 HCT 116 C62(0.86); C222(1.03); C150(1.07)  LDD0593  [18]
 LDCM0277  AC18 HCT 116 C62(0.94); C222(1.24); C150(1.35)  LDD0594  [18]
 LDCM0278  AC19 HCT 116 C62(0.99); C150(1.23); C222(1.29)  LDD0595  [18]
 LDCM0279  AC2 HCT 116 C62(1.08); C150(1.11)  LDD0596  [18]
 LDCM0280  AC20 HCT 116 C62(0.85); C222(0.97); C150(1.13)  LDD0597  [18]
 LDCM0281  AC21 HCT 116 C62(0.90); C222(1.04); C150(1.18)  LDD0598  [18]
 LDCM0282  AC22 HCT 116 C62(0.89); C150(1.07); C222(1.10)  LDD0599  [18]
 LDCM0283  AC23 HCT 116 C62(0.94); C150(1.10); C222(1.19)  LDD0600  [18]
 LDCM0284  AC24 HCT 116 C62(0.89); C222(1.03); C150(1.04)  LDD0601  [18]
 LDCM0285  AC25 HCT 116 C222(0.88); C150(0.94)  LDD0602  [18]
 LDCM0286  AC26 HCT 116 C222(0.96); C150(1.08)  LDD0603  [18]
 LDCM0287  AC27 HCT 116 C222(1.16); C150(1.30)  LDD0604  [18]
 LDCM0288  AC28 HCT 116 C222(1.11); C150(1.21)  LDD0605  [18]
 LDCM0289  AC29 HCT 116 C222(0.85); C150(1.21)  LDD0606  [18]
 LDCM0290  AC3 HCT 116 C62(1.11); C150(1.17)  LDD0607  [18]
 LDCM0291  AC30 HCT 116 C222(1.10); C150(1.23)  LDD0608  [18]
 LDCM0292  AC31 HCT 116 C150(1.06); C222(1.12)  LDD0609  [18]
 LDCM0293  AC32 HCT 116 C150(1.19); C222(1.52)  LDD0610  [18]
 LDCM0294  AC33 HCT 116 C150(1.12); C222(1.36)  LDD0611  [18]
 LDCM0295  AC34 HCT 116 C150(1.43); C222(1.54)  LDD0612  [18]
 LDCM0296  AC35 HCT 116 C222(0.84); C62(0.86); C150(0.93)  LDD0613  [18]
 LDCM0297  AC36 HCT 116 C62(0.82); C150(0.95); C222(1.49)  LDD0614  [18]
 LDCM0298  AC37 HCT 116 C62(0.74); C150(0.89); C222(1.17)  LDD0615  [18]
 LDCM0299  AC38 HCT 116 C150(0.98); C222(0.99); C62(1.21)  LDD0616  [18]
 LDCM0300  AC39 HCT 116 C62(0.94); C222(1.05); C150(1.09)  LDD0617  [18]
 LDCM0301  AC4 HCT 116 C150(1.17); C62(1.28)  LDD0618  [18]
 LDCM0302  AC40 HCT 116 C62(0.74); C150(1.07); C222(1.70)  LDD0619  [18]
 LDCM0303  AC41 HCT 116 C150(0.97); C222(1.16); C62(1.37)  LDD0620  [18]
 LDCM0304  AC42 HCT 116 C150(1.09); C62(1.11); C222(1.72)  LDD0621  [18]
 LDCM0305  AC43 HCT 116 C150(1.00); C222(1.01); C62(1.43)  LDD0622  [18]
 LDCM0306  AC44 HCT 116 C150(0.95); C222(0.98); C62(1.05)  LDD0623  [18]
 LDCM0307  AC45 HCT 116 C222(1.04); C62(1.08); C150(1.13)  LDD0624  [18]
 LDCM0308  AC46 HCT 116 C62(0.54)  LDD0625  [18]
 LDCM0309  AC47 HCT 116 C62(0.64)  LDD0626  [18]
 LDCM0310  AC48 HCT 116 C62(0.65)  LDD0627  [18]
 LDCM0311  AC49 HCT 116 C62(0.68)  LDD0628  [18]
 LDCM0312  AC5 HCT 116 C150(1.22); C62(1.29)  LDD0629  [18]
 LDCM0313  AC50 HCT 116 C62(0.54)  LDD0630  [18]
 LDCM0314  AC51 HCT 116 C62(0.80)  LDD0631  [18]
 LDCM0315  AC52 HCT 116 C62(0.62)  LDD0632  [18]
 LDCM0316  AC53 HCT 116 C62(1.25)  LDD0633  [18]
 LDCM0317  AC54 HCT 116 C62(0.74)  LDD0634  [18]
 LDCM0318  AC55 HCT 116 C62(0.86)  LDD0635  [18]
 LDCM0319  AC56 HCT 116 C62(0.66)  LDD0636  [18]
 LDCM0320  AC57 HCT 116 C62(0.92); C150(1.23)  LDD0637  [18]
 LDCM0321  AC58 HCT 116 C62(0.98); C150(1.17)  LDD0638  [18]
 LDCM0322  AC59 HCT 116 C62(0.71); C150(1.29)  LDD0639  [18]
 LDCM0323  AC6 HCT 116 C62(0.71); C150(1.06)  LDD0640  [18]
 LDCM0324  AC60 HCT 116 C62(0.83); C150(1.21)  LDD0641  [18]
 LDCM0325  AC61 HCT 116 C62(0.93); C150(1.21)  LDD0642  [18]
 LDCM0326  AC62 HCT 116 C62(0.83); C150(1.49)  LDD0643  [18]
 LDCM0327  AC63 HCT 116 C62(0.74); C150(1.56)  LDD0644  [18]
 LDCM0328  AC64 HCT 116 C62(0.88); C150(1.55)  LDD0645  [18]
 LDCM0329  AC65 HCT 116 C62(0.95); C150(1.28)  LDD0646  [18]
 LDCM0330  AC66 HCT 116 C62(1.24); C150(1.35)  LDD0647  [18]
 LDCM0331  AC67 HCT 116 C62(0.75); C150(1.44)  LDD0648  [18]
 LDCM0332  AC68 HCT 116 C62(1.25)  LDD0649  [18]
 LDCM0333  AC69 HCT 116 C62(0.96)  LDD0650  [18]
 LDCM0334  AC7 HCT 116 C62(0.78); C150(0.98)  LDD0651  [18]
 LDCM0335  AC70 HCT 116 C62(0.86)  LDD0652  [18]
 LDCM0336  AC71 HCT 116 C62(1.18)  LDD0653  [18]
 LDCM0337  AC72 HCT 116 C62(0.94)  LDD0654  [18]
 LDCM0338  AC73 HCT 116 C62(0.77)  LDD0655  [18]
 LDCM0339  AC74 HCT 116 C62(0.81)  LDD0656  [18]
 LDCM0340  AC75 HCT 116 C62(0.78)  LDD0657  [18]
 LDCM0341  AC76 HCT 116 C62(0.90)  LDD0658  [18]
 LDCM0342  AC77 HCT 116 C62(1.03)  LDD0659  [18]
 LDCM0343  AC78 HCT 116 C62(1.16)  LDD0660  [18]
 LDCM0344  AC79 HCT 116 C62(1.09)  LDD0661  [18]
 LDCM0345  AC8 HCT 116 C62(0.76); C150(1.10)  LDD0662  [18]
 LDCM0346  AC80 HCT 116 C62(1.13)  LDD0663  [18]
 LDCM0347  AC81 HCT 116 C62(1.25)  LDD0664  [18]
 LDCM0348  AC82 HCT 116 C62(0.58)  LDD0665  [18]
 LDCM0349  AC83 HCT 116 C62(0.58); C222(1.27); C150(1.37)  LDD0666  [18]
 LDCM0350  AC84 HCT 116 C62(0.68); C222(0.94); C150(1.21)  LDD0667  [18]
 LDCM0351  AC85 HCT 116 C62(0.77); C222(1.26); C150(1.36)  LDD0668  [18]
 LDCM0352  AC86 HCT 116 C62(0.59); C222(0.93); C150(1.49)  LDD0669  [18]
 LDCM0353  AC87 HCT 116 C62(0.57); C222(0.89); C150(1.17)  LDD0670  [18]
 LDCM0354  AC88 HCT 116 C62(0.68); C222(1.02); C150(1.31)  LDD0671  [18]
 LDCM0355  AC89 HCT 116 C62(0.62); C222(0.89); C150(1.22)  LDD0672  [18]
 LDCM0357  AC90 HCT 116 C62(0.71); C222(0.98); C150(1.56)  LDD0674  [18]
 LDCM0358  AC91 HCT 116 C62(0.85); C150(1.08); C222(1.61)  LDD0675  [18]
 LDCM0359  AC92 HCT 116 C62(0.77); C150(1.43); C222(1.72)  LDD0676  [18]
 LDCM0360  AC93 HCT 116 C62(0.72); C222(0.88); C150(1.10)  LDD0677  [18]
 LDCM0361  AC94 HCT 116 C62(0.69); C150(1.33); C222(1.82)  LDD0678  [18]
 LDCM0362  AC95 HCT 116 C62(0.57); C222(0.75); C150(1.41)  LDD0679  [18]
 LDCM0363  AC96 HCT 116 C62(0.82); C150(1.10); C222(1.22)  LDD0680  [18]
 LDCM0364  AC97 HCT 116 C62(0.64); C222(1.01); C150(1.38)  LDD0681  [18]
 LDCM0365  AC98 HCT 116 C62(0.66); C150(1.73)  LDD0682  [18]
 LDCM0366  AC99 HCT 116 C62(0.63); C150(0.97)  LDD0683  [18]
 LDCM0545  Acetamide MDA-MB-231 C150(0.39)  LDD2138  [17]
 LDCM0520  AKOS000195272 MDA-MB-231 C150(0.55)  LDD2113  [17]
 LDCM0248  AKOS034007472 HCT 116 C150(1.08); C62(1.16)  LDD0565  [18]
 LDCM0356  AKOS034007680 HCT 116 C62(0.86); C150(1.11)  LDD0673  [18]
 LDCM0275  AKOS034007705 HCT 116 C62(0.42); C150(1.56)  LDD0592  [18]
 LDCM0156  Aniline NCI-H1299 12.20  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C150(0.91)  LDD2171  [18]
 LDCM0498  BS-3668 MDA-MB-231 C150(0.61)  LDD2091  [17]
 LDCM0630  CCW28-3 231MFP C150(1.10); C441(0.56)  LDD2214  [19]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [14]
 LDCM0632  CL-Sc Hep-G2 C150(0.55)  LDD2227  [11]
 LDCM0367  CL1 HCT 116 C150(1.03); C62(1.49)  LDD0684  [18]
 LDCM0368  CL10 HCT 116 C150(0.80); C62(1.40)  LDD0685  [18]
 LDCM0369  CL100 HCT 116 C62(0.92); C150(1.13)  LDD0686  [18]
 LDCM0370  CL101 HCT 116 C62(0.70); C150(1.06)  LDD0687  [18]
 LDCM0371  CL102 HCT 116 C62(0.83); C150(1.01)  LDD0688  [18]
 LDCM0372  CL103 HCT 116 C150(0.92); C62(1.02)  LDD0689  [18]
 LDCM0373  CL104 HCT 116 C62(0.89); C150(1.05)  LDD0690  [18]
 LDCM0374  CL105 HCT 116 C62(0.81); C222(1.05); C150(1.22)  LDD0691  [18]
 LDCM0375  CL106 HCT 116 C62(0.82); C222(1.34); C150(1.45)  LDD0692  [18]
 LDCM0376  CL107 HCT 116 C62(0.85); C222(1.21); C150(1.43)  LDD0693  [18]
 LDCM0377  CL108 HCT 116 C62(1.00); C222(1.32); C150(1.51)  LDD0694  [18]
 LDCM0378  CL109 HCT 116 C62(0.84); C222(1.19); C150(1.28)  LDD0695  [18]
 LDCM0379  CL11 HCT 116 C150(0.97); C62(1.24)  LDD0696  [18]
 LDCM0380  CL110 HCT 116 C62(0.95); C150(1.29); C222(1.33)  LDD0697  [18]
 LDCM0381  CL111 HCT 116 C62(0.81); C150(1.21); C222(1.25)  LDD0698  [18]
 LDCM0382  CL112 HCT 116 C150(0.95); C222(1.00)  LDD0699  [18]
 LDCM0383  CL113 HCT 116 C150(1.05); C222(1.05)  LDD0700  [18]
 LDCM0384  CL114 HCT 116 C150(0.98); C222(1.48)  LDD0701  [18]
 LDCM0385  CL115 HCT 116 C222(1.06); C150(1.14)  LDD0702  [18]
 LDCM0386  CL116 HCT 116 C222(0.93); C150(1.15)  LDD0703  [18]
 LDCM0387  CL117 HCT 116 C62(1.46); C150(1.80); C222(1.89)  LDD0704  [18]
 LDCM0388  CL118 HCT 116 C62(0.93); C150(1.17); C222(1.38)  LDD0705  [18]
 LDCM0389  CL119 HCT 116 C222(1.01); C62(1.13); C150(1.18)  LDD0706  [18]
 LDCM0390  CL12 HCT 116 C150(0.82); C62(0.95)  LDD0707  [18]
 LDCM0391  CL120 HCT 116 C222(0.93); C150(0.97); C62(1.22)  LDD0708  [18]
 LDCM0392  CL121 HCT 116 C62(0.65)  LDD0709  [18]
 LDCM0393  CL122 HCT 116 C62(0.70)  LDD0710  [18]
 LDCM0394  CL123 HCT 116 C62(0.59)  LDD0711  [18]
 LDCM0395  CL124 HCT 116 C62(0.70)  LDD0712  [18]
 LDCM0396  CL125 HCT 116 C62(0.66); C150(0.95)  LDD0713  [18]
 LDCM0397  CL126 HCT 116 C62(0.87); C150(1.07)  LDD0714  [18]
 LDCM0398  CL127 HCT 116 C62(0.69); C150(0.97)  LDD0715  [18]
 LDCM0399  CL128 HCT 116 C62(0.70); C150(1.24)  LDD0716  [18]
 LDCM0400  CL13 HCT 116 C150(0.86); C62(1.78)  LDD0717  [18]
 LDCM0401  CL14 HCT 116 C150(0.85); C62(1.21)  LDD0718  [18]
 LDCM0402  CL15 HCT 116 C150(0.82); C62(1.81)  LDD0719  [18]
 LDCM0403  CL16 HCT 116 C62(0.86); C150(0.94)  LDD0720  [18]
 LDCM0404  CL17 HCT 116 C62(0.89); C150(0.93)  LDD0721  [18]
 LDCM0405  CL18 HCT 116 C62(1.09); C150(1.13)  LDD0722  [18]
 LDCM0406  CL19 HCT 116 C150(1.24); C62(1.30)  LDD0723  [18]
 LDCM0407  CL2 HCT 116 C150(0.93); C62(1.45)  LDD0724  [18]
 LDCM0408  CL20 HCT 116 C62(1.08); C150(1.36)  LDD0725  [18]
 LDCM0409  CL21 HCT 116 C62(1.09); C150(1.44)  LDD0726  [18]
 LDCM0410  CL22 HCT 116 C62(0.96); C150(1.49)  LDD0727  [18]
 LDCM0411  CL23 HCT 116 C62(0.92); C150(1.23)  LDD0728  [18]
 LDCM0412  CL24 HCT 116 C62(1.29); C150(1.36)  LDD0729  [18]
 LDCM0413  CL25 HCT 116 C150(1.26); C62(1.25)  LDD0730  [18]
 LDCM0414  CL26 HCT 116 C150(1.13); C62(0.70)  LDD0731  [18]
 LDCM0415  CL27 HCT 116 C150(1.24); C62(1.76)  LDD0732  [18]
 LDCM0416  CL28 HCT 116 C150(1.27); C62(1.18)  LDD0733  [18]
 LDCM0417  CL29 HCT 116 C150(1.29); C62(2.08)  LDD0734  [18]
 LDCM0418  CL3 HCT 116 C150(0.93); C62(1.67)  LDD0735  [18]
 LDCM0419  CL30 HCT 116 C150(1.14); C62(1.39)  LDD0736  [18]
 LDCM0420  CL31 HCT 116 C150(0.98); C222(1.05); C62(0.78)  LDD0737  [18]
 LDCM0421  CL32 HCT 116 C150(1.03); C222(1.20); C62(0.68)  LDD0738  [18]
 LDCM0422  CL33 HCT 116 C150(1.07); C222(2.16); C62(0.65)  LDD0739  [18]
 LDCM0423  CL34 HCT 116 C150(0.94); C222(1.78); C62(0.76)  LDD0740  [18]
 LDCM0424  CL35 HCT 116 C150(1.10); C222(1.36); C62(0.64)  LDD0741  [18]
 LDCM0425  CL36 HCT 116 C150(1.06); C222(1.89); C62(0.81)  LDD0742  [18]
 LDCM0426  CL37 HCT 116 C150(1.29); C222(2.93); C62(0.72)  LDD0743  [18]
 LDCM0428  CL39 HCT 116 C150(1.10); C222(1.30); C62(0.85)  LDD0745  [18]
 LDCM0429  CL4 HCT 116 C150(0.98); C62(1.91)  LDD0746  [18]
 LDCM0430  CL40 HCT 116 C150(1.18); C222(1.20); C62(0.63)  LDD0747  [18]
 LDCM0431  CL41 HCT 116 C150(0.95); C222(1.22); C62(0.76)  LDD0748  [18]
 LDCM0432  CL42 HCT 116 C150(1.07); C222(2.52); C62(0.85)  LDD0749  [18]
 LDCM0433  CL43 HCT 116 C150(0.95); C222(2.15); C62(0.63)  LDD0750  [18]
 LDCM0434  CL44 HCT 116 C150(1.10); C222(1.54); C62(0.87)  LDD0751  [18]
 LDCM0435  CL45 HCT 116 C150(1.01); C222(2.39); C62(0.83)  LDD0752  [18]
 LDCM0436  CL46 HCT 116 C150(0.82); C222(0.62); C62(1.03)  LDD0753  [18]
 LDCM0437  CL47 HCT 116 C150(0.82); C222(0.76); C62(0.92)  LDD0754  [18]
 LDCM0438  CL48 HCT 116 C150(0.89); C222(0.73); C62(1.37)  LDD0755  [18]
 LDCM0439  CL49 HCT 116 C150(0.89); C222(1.08); C62(2.34)  LDD0756  [18]
 LDCM0440  CL5 HCT 116 C150(0.82); C62(2.64)  LDD0757  [18]
 LDCM0441  CL50 HCT 116 C150(0.83); C222(0.74); C62(1.30)  LDD0758  [18]
 LDCM0442  CL51 HCT 116 C150(0.92); C222(0.69); C62(1.62)  LDD0759  [18]
 LDCM0443  CL52 HCT 116 C150(0.86); C222(0.88); C62(0.84)  LDD0760  [18]
 LDCM0444  CL53 HCT 116 C150(0.87); C222(1.11); C62(1.12)  LDD0761  [18]
 LDCM0445  CL54 HCT 116 C150(0.82); C222(0.74); C62(1.18)  LDD0762  [18]
 LDCM0446  CL55 HCT 116 C150(0.78); C222(0.74); C62(1.39)  LDD0763  [18]
 LDCM0447  CL56 HCT 116 C150(0.95); C222(0.91); C62(1.30)  LDD0764  [18]
 LDCM0448  CL57 HCT 116 C150(0.75); C222(0.79); C62(1.42)  LDD0765  [18]
 LDCM0449  CL58 HCT 116 C150(0.92); C222(0.72); C62(0.95)  LDD0766  [18]
 LDCM0450  CL59 HCT 116 C150(0.89); C222(0.97); C62(1.34)  LDD0767  [18]
 LDCM0451  CL6 HCT 116 C150(0.82); C62(1.70)  LDD0768  [18]
 LDCM0452  CL60 HCT 116 C150(0.96); C222(0.91); C62(1.19)  LDD0769  [18]
 LDCM0453  CL61 HCT 116 C150(1.04); C222(1.13)  LDD0770  [18]
 LDCM0454  CL62 HCT 116 C150(1.01); C222(1.41)  LDD0771  [18]
 LDCM0455  CL63 HCT 116 C150(1.15); C222(1.25)  LDD0772  [18]
 LDCM0456  CL64 HCT 116 C150(1.13); C222(1.48)  LDD0773  [18]
 LDCM0457  CL65 HCT 116 C150(0.97); C222(1.34)  LDD0774  [18]
 LDCM0458  CL66 HCT 116 C150(1.29); C222(1.94)  LDD0775  [18]
 LDCM0459  CL67 HCT 116 C150(1.13); C222(1.32)  LDD0776  [18]
 LDCM0460  CL68 HCT 116 C150(1.13); C222(1.58)  LDD0777  [18]
 LDCM0461  CL69 HCT 116 C150(0.98); C222(0.97)  LDD0778  [18]
 LDCM0462  CL7 HCT 116 C150(0.77); C62(1.83)  LDD0779  [18]
 LDCM0463  CL70 HCT 116 C150(1.09); C222(1.89)  LDD0780  [18]
 LDCM0464  CL71 HCT 116 C150(1.17); C222(1.68)  LDD0781  [18]
 LDCM0465  CL72 HCT 116 C150(1.06); C222(1.03)  LDD0782  [18]
 LDCM0466  CL73 HCT 116 C150(1.00); C222(1.39)  LDD0783  [18]
 LDCM0467  CL74 HCT 116 C150(1.08); C222(1.40)  LDD0784  [18]
 LDCM0469  CL76 HCT 116 C150(1.12); C62(0.62)  LDD0786  [18]
 LDCM0470  CL77 HCT 116 C150(1.07); C62(1.09)  LDD0787  [18]
 LDCM0471  CL78 HCT 116 C150(1.21); C62(0.39)  LDD0788  [18]
 LDCM0472  CL79 HCT 116 C150(1.45); C62(0.47)  LDD0789  [18]
 LDCM0473  CL8 HCT 116 C150(0.92); C62(0.87)  LDD0790  [18]
 LDCM0474  CL80 HCT 116 C150(1.14); C62(0.64)  LDD0791  [18]
 LDCM0475  CL81 HCT 116 C150(1.39); C62(0.60)  LDD0792  [18]
 LDCM0476  CL82 HCT 116 C150(1.87); C62(0.37)  LDD0793  [18]
 LDCM0477  CL83 HCT 116 C150(1.55); C62(0.48)  LDD0794  [18]
 LDCM0478  CL84 HCT 116 C150(1.80); C62(0.37)  LDD0795  [18]
 LDCM0479  CL85 HCT 116 C150(1.18); C62(0.63)  LDD0796  [18]
 LDCM0480  CL86 HCT 116 C150(1.05); C62(0.66)  LDD0797  [18]
 LDCM0481  CL87 HCT 116 C150(1.10); C62(0.52)  LDD0798  [18]
 LDCM0482  CL88 HCT 116 C150(1.52); C62(0.37)  LDD0799  [18]
 LDCM0483  CL89 HCT 116 C150(2.17); C62(0.32)  LDD0800  [18]
 LDCM0484  CL9 HCT 116 C150(0.86); C62(1.49)  LDD0801  [18]
 LDCM0485  CL90 HCT 116 C150(1.08); C62(0.59)  LDD0802  [18]
 LDCM0486  CL91 HCT 116 C150(1.18); C62(1.05)  LDD0803  [18]
 LDCM0487  CL92 HCT 116 C150(1.06); C62(1.08)  LDD0804  [18]
 LDCM0488  CL93 HCT 116 C150(1.03); C62(1.07)  LDD0805  [18]
 LDCM0489  CL94 HCT 116 C150(1.03); C62(1.13)  LDD0806  [18]
 LDCM0490  CL95 HCT 116 C150(1.30); C62(1.04)  LDD0807  [18]
 LDCM0491  CL96 HCT 116 C150(1.16); C62(1.58)  LDD0808  [18]
 LDCM0492  CL97 HCT 116 C150(1.11); C62(1.16)  LDD0809  [18]
 LDCM0493  CL98 HCT 116 C150(1.29); C62(0.81)  LDD0810  [18]
 LDCM0494  CL99 HCT 116 C150(0.96); C62(0.93)  LDD0811  [18]
 LDCM0495  E2913 HEK-293T C441(1.02); C150(0.87); C62(1.24); C222(1.20)  LDD1698  [20]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C441(0.92)  LDD1702  [17]
 LDCM0625  F8 Ramos C441(1.03); C150(1.36); C222(1.22)  LDD2187  [21]
 LDCM0572  Fragment10 Ramos C441(2.61); C150(3.49); C222(2.77); C62(0.75)  LDD2189  [21]
 LDCM0573  Fragment11 Ramos C441(0.09); C150(0.65); C222(2.75); C62(0.56)  LDD2190  [21]
 LDCM0574  Fragment12 Ramos C441(1.41); C150(3.24); C222(2.00)  LDD2191  [21]
 LDCM0575  Fragment13 MDA-MB-231 C150(0.65)  LDD1395  [22]
 LDCM0576  Fragment14 Ramos C150(6.34)  LDD1398  [22]
 LDCM0579  Fragment20 Ramos C441(1.25); C150(3.98); C222(1.90); C62(0.70)  LDD2194  [21]
 LDCM0580  Fragment21 Ramos C441(1.15); C150(1.02); C222(1.02)  LDD2195  [21]
 LDCM0582  Fragment23 Ramos C441(1.14); C150(1.99); C222(1.09)  LDD2196  [21]
 LDCM0578  Fragment27 Ramos C441(1.11); C150(0.86); C222(0.91)  LDD2197  [21]
 LDCM0586  Fragment28 MDA-MB-231 C150(1.36)  LDD1415  [22]
 LDCM0588  Fragment30 Ramos C441(1.83); C150(1.68); C222(1.48); C62(0.92)  LDD2199  [21]
 LDCM0589  Fragment31 Ramos C441(1.15); C150(1.83); C222(1.02)  LDD2200  [21]
 LDCM0590  Fragment32 MDA-MB-231 C150(1.78)  LDD1423  [22]
 LDCM0468  Fragment33 HCT 116 C150(1.05); C222(1.61)  LDD0785  [18]
 LDCM0596  Fragment38 Ramos C441(1.15); C150(2.32); C222(1.14); C62(0.66)  LDD2203  [21]
 LDCM0566  Fragment4 MDA-MB-231 C150(20.00)  LDD1378  [22]
 LDCM0599  Fragment41 MDA-MB-231 C150(1.92)  LDD1438  [22]
 LDCM0427  Fragment51 HCT 116 C150(1.34); C222(2.28); C62(0.59)  LDD0744  [18]
 LDCM0610  Fragment52 Ramos C441(0.97); C150(1.39); C222(1.18)  LDD2204  [21]
 LDCM0614  Fragment56 MDA-MB-231 C150(0.85)  LDD1458  [22]
 LDCM0569  Fragment7 Ramos C441(1.27); C150(3.05); C222(1.78)  LDD2186  [21]
 LDCM0570  Fragment8 Ramos C150(1.51)  LDD1386  [22]
 LDCM0571  Fragment9 Ramos C441(1.59); C150(3.98); C222(2.12); C62(0.71)  LDD2188  [21]
 LDCM0116  HHS-0101 DM93 Y59(0.75)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y59(0.79)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y59(0.76)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y59(0.79)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y59(1.12)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [14]
 LDCM0022  KB02 MDA-MB-231 C150(2.49)  LDD1374  [22]
 LDCM0023  KB03 Jurkat C441(4.98); C150(149.39)  LDD0209  [5]
 LDCM0024  KB05 COLO792 C150(4.92)  LDD3310  [23]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C150(1.34)  LDD2102  [17]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C150(0.65)  LDD2121  [17]
 LDCM0109  NEM HeLa N.A.  LDD0223  [14]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C150(0.74)  LDD2089  [17]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C150(1.02)  LDD2092  [17]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C150(1.07)  LDD2093  [17]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C150(1.18)  LDD2094  [17]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C150(1.08)  LDD2097  [17]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C150(1.12)  LDD2098  [17]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C150(1.34)  LDD2099  [17]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C150(0.87)  LDD2100  [17]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C150(0.55)  LDD2101  [17]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C150(0.85)  LDD2104  [17]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C150(1.25)  LDD2105  [17]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C150(0.78)  LDD2106  [17]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C150(1.18)  LDD2107  [17]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C150(1.00)  LDD2108  [17]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C150(0.87)  LDD2109  [17]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C150(1.08)  LDD2111  [17]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C150(0.53)  LDD2114  [17]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C150(0.56)  LDD2115  [17]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C150(0.70)  LDD2118  [17]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C150(1.40)  LDD2119  [17]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C150(0.89)  LDD2122  [17]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C150(0.94)  LDD2123  [17]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C150(0.69)  LDD2124  [17]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C150(1.05); C441(1.73)  LDD2125  [17]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C150(0.98); C441(0.97)  LDD2127  [17]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C150(0.90)  LDD2128  [17]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C150(1.04)  LDD2129  [17]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C150(0.56)  LDD2133  [17]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C150(0.91)  LDD2135  [17]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C150(1.31); C441(1.13)  LDD2136  [17]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C150(1.01); C441(1.05)  LDD2137  [17]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C150(1.07)  LDD2140  [17]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C150(0.96); C441(1.01)  LDD2141  [17]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C150(1.10)  LDD2143  [17]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C150(1.92)  LDD2144  [17]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C150(7.18)  LDD2145  [17]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C150(0.94)  LDD2146  [17]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C150(0.51)  LDD2148  [17]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C150(0.67)  LDD2149  [17]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C150(0.62)  LDD2150  [17]
 LDCM0627  NUDT7-COV-1 HEK-293T C150(0.43)  LDD2206  [24]
 LDCM0628  OTUB2-COV-1 HEK-293T C150(0.96)  LDD2207  [24]
 LDCM0131  RA190 MM1.R C441(1.29)  LDD0304  [25]
 LDCM0021  THZ1 HCT 116 C150(0.91)  LDD2173  [18]
 LDCM0112  W16 Hep-G2 C441(0.67)  LDD0239  [7]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SMYD3 (SMYD3) Histone-lysine methyltransferase family Q9H7B4
Mitochondrial inner membrane protease ATP23 homolog (ATP23) Peptidase M76 family Q9Y6H3
Carboxy-terminal domain RNA polymerase II polypeptide A small phosphatase 1 (CTDSP1) . Q9GZU7
Transcription factor
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein PKNOX2 (PKNOX2) TALE/MEIS homeobox family Q96KN3
Forkhead box protein J2 (FOXJ2) . Q9P0K8
Other
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
A-kinase anchor protein 8-like (AKAP8L) AKAP95 family Q9ULX6
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Collagen alpha-1(XVII) chain (COL17A1) . Q9UMD9
Hepatocyte growth factor-regulated tyrosine kinase substrate (HGS) . O14964
Saitohin (STH) . Q8IWL8
Ubiquilin-1 (UBQLN1) . Q9UMX0
Ubiquilin-2 (UBQLN2) . Q9UHD9

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
10 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
11 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
12 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
13 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
16 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
17 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
18 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
19 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
20 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
21 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
22 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
23 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
24 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
25 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.