Probe Name	IA-alkyne					Probe Info
Probe concentration	100 uM
Criteria	Quantification: Probe vs (Probe+Competitor)
Quantitative Method	Isotope tag
Competitor Name	Fragment14					Competitor Info
Competitor Concentration	500 uM
In Vivo Experiment Model	Model Type			Cell lysate
	Derived Tissue			Lymph node
	Disease Model		Burkitt lymphoma [ICD-11:2A85]
	Model Name		Human burkitt lymphoma cell lysate (Ramos)

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP04076	Mitogen-activated protein kinase 9 (MAPK9)				C177	20.0
LDTP12166	Ras-related GTP-binding protein C (RRAGC)				C377	20.0
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C140	16.7
LDTP07651	Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L)				C906	15.9
LDTP00701	D-3-phosphoglycerate dehydrogenase (PHGDH)				C369	13.8
LDTP02522	60 kDa heat shock protein, mitochondrial (HSPD1)				C442	9.9
LDTP09598	Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8)				C207	7.8
LDTP10386	ERO1-like protein alpha (ERO1A)				C166	7.1
LDTP09912	DNA repair protein RAD50 (RAD50)				C102	6.0
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C918	4.3
LDTP14535	6-phosphogluconolactonase (PGLS)				C32	4.1
LDTP07098	Probable ATP-dependent RNA helicase DDX59 (DDX59)				C414	4.0
LDTP04601	Arginine--tRNA ligase, cytoplasmic (RARS1)				C34	3.5
LDTP17247	5'-nucleotidase domain-containing protein 1 (NT5DC1)				C119	3.3
LDTP00246	Eukaryotic translation initiation factor 3 subunit F (EIF3F)				C256	3.1
LDTP10418	Mannose-1-phosphate guanyltransferase alpha (GMPPA)				C389	3.0
LDTP05314	ATP-dependent 6-phosphofructokinase, platelet type (PFKP)				C179	2.9
LDTP16025	Ketosamine-3-kinase (FN3KRP)				C24	2.7
LDTP17384	Lysine-specific demethylase RSBN1L (RSBN1L)				C280	2.6
LDTP03512	Peroxiredoxin-5, mitochondrial (PRDX5)				C204	2.6
LDTP02580	C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1)				C863	2.6
LDTP10386	ERO1-like protein alpha (ERO1A)				C241	2.5
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C129	2.5
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C376	2.5
LDTP10954	3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10)				C214	2.3
LDTP01245	Enoyl-CoA delta isomerase 2 (ECI2)				C380	2.3
LDTP07907	Tubulin alpha-1A chain (TUBA1A)				C347	2.2
LDTP09412	Serine/threonine-protein kinase Nek9 (NEK9)				C623	2.2
LDTP05859	Integrin-linked protein kinase (ILK)				C346	2.1
LDTP02333	Glutathione S-transferase P (GSTP1)				C48	2.1
LDTP12166	Ras-related GTP-binding protein C (RRAGC)				C358	2.1
LDTP05128	Glutathione S-transferase omega-1 (GSTO1)				C32	2.1
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C347	2.1
LDTP11107	Serine/threonine-protein phosphatase CPPED1 (CPPED1)				C54	2.0
LDTP03159	Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS)				C374	2.0
LDTP01470	Lysine-specific demethylase 4B (KDM4B)				C694	2.0
LDTP02502	Thioredoxin (TXN)				C32	1.9
LDTP06211	Caspase-8 (CASP8)				C360	1.9
LDTP04374	Dynamin-2 (DNM2)				C27	1.9
LDTP10878	Parkinson disease protein 7 (PARK7)				C106	1.8
LDTP06199	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D)				C17	1.8
LDTP02188	Protein disulfide-isomerase (P4HB)				C397	1.8
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C721	1.8
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C295	1.8
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C119	1.8
LDTP06150	DNA replication licensing factor MCM6 (MCM6)				C301	1.7
LDTP03400	Deoxycytidine kinase (DCK)				C45	1.7
LDTP03299	Cyclin-dependent kinase 2 (CDK2)				C177	1.7
LDTP04424	Galactokinase (GALK1)				C182	1.7
LDTP05075	Tubulin alpha-4A chain (TUBA4A)				C315	1.7
LDTP13449	Cleavage and polyadenylation specificity factor subunit 3 (CPSF3)				C498	1.6
LDTP11340	Cyclin-dependent kinase 19 (CDK19)				C349	1.6
LDTP03223	Small ribosomal subunit protein uS3 (RPS3)				C97	1.6
LDTP02022	Thymidine kinase, cytosolic (TK1)				C66	1.6
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C413	1.6
LDTP04689	Adenosine kinase (ADK)				C353	1.6
LDTP13147	Cathepsin Z (CTSZ)				C92	1.6
LDTP03400	Deoxycytidine kinase (DCK)				C9	1.6
LDTP10386	ERO1-like protein alpha (ERO1A)				C37	1.6
LDTP12428	Omega-amidase NIT2 (NIT2)				C153	1.6
LDTP17082	Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1)				C137	1.6
LDTP03998	3-ketoacyl-CoA thiolase, mitochondrial (ACAA2)				C92	1.6
LDTP02765	Aldo-keto reductase family 1 member B1 (AKR1B1)				C299	1.6
LDTP09338	NEDD8-activating enzyme E1 catalytic subunit (UBA3)				C237	1.6
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C206	1.6
LDTP03521	Protein disulfide-isomerase A3 (PDIA3)				C406	1.6
LDTP02677	Protein disulfide-isomerase A4 (PDIA4)				C555	1.6
LDTP11030	Serine/threonine-protein kinase VRK1 (VRK1)				C50	1.5
LDTP12190	NmrA-like family domain-containing protein 1 (NMRAL1)				C154	1.5
LDTP02693	Acylamino-acid-releasing enzyme (APEH)				C641	1.5
LDTP01495	E3 ubiquitin-protein ligase UBR5 (UBR5)				C2267	1.5
LDTP05773	Peroxiredoxin-4 (PRDX4)				C51	1.5
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C196	1.4
LDTP10929	Cell cycle checkpoint control protein RAD9A (RAD9A)				C114	1.4
LDTP02672	Elongation factor 2 (EEF2)				C41	1.4
LDTP10177	Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2)				C64	1.4
LDTP06314	Protein disulfide-isomerase A6 (PDIA6)				C55	1.4
LDTP10997	Protein arginine N-methyltransferase 1 (PRMT1)				C109	1.4
LDTP00273	Dynamin-1-like protein (DNM1L)				C367	1.4
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C217	1.4
LDTP02038	Glyceraldehyde-3-phosphate dehydrogenase (GAPDH)				C152	1.4
LDTP00089	Glycerol-3-phosphate phosphatase (PGP)				C297	1.4
LDTP01633	Persulfide dioxygenase ETHE1, mitochondrial (ETHE1)				C170	1.4
LDTP15306	Transmembrane protease serine 12 (TMPRSS12)				C64	1.4
LDTP03291	Acetyl-CoA acetyltransferase, mitochondrial (ACAT1)				C126	1.4
LDTP03152	Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1)				C102	1.4
LDTP08181	Glutaredoxin-related protein 5, mitochondrial (GLRX5)				C67	1.3
LDTP01333	Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1)				C269	1.3
LDTP09067	Thioredoxin domain-containing protein 5 (TXNDC5)				C350	1.3
LDTP06338	Prostaglandin E synthase 3 (PTGES3)				C58	1.3
LDTP12960	[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1)				C149	1.3
LDTP02733	Pyruvate kinase PKM (PKM)				C423	1.3
LDTP05912	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1)				C113	1.2
LDTP11388	N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15)				C322	1.2
LDTP06621	Ubiquitin-conjugating enzyme E2 S (UBE2S)				C118	1.2
LDTP05070	Ubiquitin-conjugating enzyme E2 L3 (UBE2L3)				C86	1.1
LDTP03786	Glutaredoxin-1 (GLRX)				C23	1.1
LDTP04306	Adenosine 5'-monophosphoramidase HINT1 (HINT1)				C84	1.0
LDTP04265	Serine--tRNA ligase, cytoplasmic (SARS1)				C438	1.0
LDTP02611	Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2)				C331	1.0
LDTP02672	Elongation factor 2 (EEF2)				C136	0.9
LDTP03644	Pyrroline-5-carboxylate reductase 1, mitochondrial (PYCR1)				C120	0.9
LDTP04061	26S proteasome regulatory subunit 6B (PSMC4)				C210	0.7
LDTP02329	3-ketoacyl-CoA thiolase, peroxisomal (ACAA1)				C381	0.7
LDTP04077	Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4)				C246	0.3

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP00501	Exportin-1 (XPO1)				C528	20.0
LDTP08769	Nuclear pore complex protein Nup93 (NUP93)				C522	8.4
LDTP11103	Thioredoxin domain-containing protein 17 (TXNDC17)				C43	4.6
LDTP04259	Signal recognition particle 9 kDa protein (SRP9)				C48	4.4
LDTP04662	Exportin-2 (CSE1L)				C842	1.8
LDTP00244	Chloride intracellular channel protein 1 (CLIC1)				C24	1.7
LDTP04801	Gasdermin-D (GSDMD)				C268	1.7
LDTP13490	Apoptotic chromatin condensation inducer in the nucleus (ACIN1)				C1223	1.7
LDTP08315	THO complex subunit 6 homolog (THOC6)				C35	1.6
LDTP14222	Chloride intracellular channel protein 4 (CLIC4)				C35	1.5
LDTP00501	Exportin-1 (XPO1)				C34	1.5
LDTP05057	Small ribosomal subunit protein RACK1 (RACK1)				C182	1.5
LDTP13661	Sorting nexin-6 (SNX6)				C264	1.4
LDTP04707	Protein SEC13 homolog (SEC13)				C187	1.3
LDTP01574	Importin-7 (IPO7)				C757	1.1

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP12507	Chromatin accessibility complex protein 1 (CHRAC1)				C55	3.3
LDTP12792	CDKN2A-interacting protein (CDKN2AIP)				C516	2.7
LDTP05284	Transcription factor RelB (RELB)				C109	2.4
LDTP09311	SWI/SNF complex subunit SMARCC2 (SMARCC2)				C145	2.3
LDTP02016	Glucocorticoid receptor (NR3C1)				C302	2.2
LDTP05485	Recombining binding protein suppressor of hairless (RBPJ)				C313	1.7
LDTP07940	eIF5-mimic protein 2 (BZW1)				C35	1.4
LDTP06341	Non-POU domain-containing octamer-binding protein (NONO)				C145	1.2

Target ID	Target Name				Binding Sites	Binding Ratio
LDTP06378	Disks large-associated protein 5 (DLGAP5)				C129	20.0
LDTP04518	DNA mismatch repair protein Msh6 (MSH6)				C1117	20.0
LDTP05867	Treacle protein (TCOF1)				C38	20.0
LDTP01299	WD repeat and HMG-box DNA-binding protein 1 (WDHD1)				C773	20.0
LDTP10843	MMS19 nucleotide excision repair protein homolog (MMS19)				C848	12.5
LDTP11197	Mini-chromosome maintenance complex-binding protein (MCMBP)				C325	10.8
LDTP11718	Cleavage stimulation factor subunit 2 tau variant (CSTF2T)				C150	6.3
LDTP01532	ZW10 interactor (ZWINT)				C54	5.7
LDTP06281	Condensin complex subunit 1 (NCAPD2)				C767	5.6
LDTP03665	Cleavage stimulation factor subunit 2 (CSTF2)				C150	4.7
LDTP05484	Proteasome activator complex subunit 1 (PSME1)				C22	4.0
LDTP07755	Dynamin-binding protein (DNMBP)				C691	3.8
LDTP12685	Integrator complex subunit 13 (INTS13)				C349	3.6
LDTP05008	Large ribosomal subunit protein uL14 (RPL23)				C28	3.4
LDTP13979	Cytosolic iron-sulfur assembly component 2B (CIAO2B)				C93	3.2
LDTP11212	Tubulin-specific chaperone D (TBCD)				C850	3.1
LDTP15730	Ataxin-7-like protein 3B (ATXN7L3B)				C75	3.1
LDTP04997	Small ribosomal subunit protein eS4, X isoform (RPS4X)				C41	3.1
LDTP06250	Proteasome activator complex subunit 4 (PSME4)				C1840	3.1
LDTP15701	EF-hand domain-containing protein D2 (EFHD2)				C172	2.9
LDTP12737	BRISC and BRCA1-A complex member 1 (BABAM1)				C222	2.7
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C291	2.5
LDTP04092	Crk-like protein (CRKL)				C249	2.5
LDTP00202	AH receptor-interacting protein (AIP)				C122	2.5
LDTP11191	WW domain-containing adapter protein with coiled-coil (WAC)				C553	2.5
LDTP03987	Small ribosomal subunit protein eS27 (RPS27)				C77	2.4
LDTP12914	Hsp70-binding protein 1 (HSPBP1)				C204	2.3
LDTP10299	Enhancer of mRNA-decapping protein 3 (EDC3)				C413	2.3
LDTP04110	Small ribosomal subunit protein uS7 (RPS5)				C66	2.3
LDTP03395	Large ribosomal subunit protein uL16 (RPL10)				C105	2.3
LDTP02205	Tubulin beta chain (TUBB)				C239	2.1
LDTP10990	T-complex protein 1 subunit eta (CCT7)				C29	2.1
LDTP13817	Nuclear migration protein nudC (NUDC)				C188	2.1
LDTP05867	Treacle protein (TCOF1)				C1298	2.1
LDTP00552	Actin-related protein 2/3 complex subunit 3 (ARPC3)				C162	2.0
LDTP11239	Protein misato homolog 1 (MSTO1)				C403	2.0
LDTP05021	Large ribosomal subunit protein eL30 (RPL30)				C92	1.9
LDTP03815	Large ribosomal subunit protein uL4 (RPL4)				C96	1.9
LDTP15677	Ribosomal protein eL42-like (RPL36AL)				C88	1.9
LDTP02205	Tubulin beta chain (TUBB)				C354	1.9
LDTP12571	LanC-like protein 2 (LANCL2)				C187	1.8
LDTP11890	Protein unc-45 homolog A (UNC45A)				C426	1.8
LDTP01567	Structural maintenance of chromosomes protein 2 (SMC2)				C1174	1.8
LDTP03865	Large ribosomal subunit protein uL3 (RPL3)				C253	1.8
LDTP05770	Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2)				C23	1.8
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C60	1.8
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C267	1.7
LDTP13964	MOB-like protein phocein (MOB4)				C134	1.7
LDTP02934	T-complex protein 1 subunit alpha (TCP1)				C76	1.7
LDTP06082	Dynactin subunit 1 (DCTN1)				C1252	1.7
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C341	1.7
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C6	1.7
LDTP12780	THUMP domain-containing protein 1 (THUMPD1)				C31	1.7
LDTP05186	Large ribosomal subunit protein eL24 (RPL24)				C36	1.6
LDTP13580	Coronin-1C (CORO1C)				C420	1.6
LDTP10781	NudC domain-containing protein 1 (NUDCD1)				C376	1.6
LDTP06083	Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)				C1999	1.6
LDTP03967	Lamina-associated polypeptide 2, isoform alpha (TMPO)				C280	1.6
LDTP10864	Calponin-2 (CNN2)				C164	1.6
LDTP14195	FH1/FH2 domain-containing protein 1 (FHOD1)				C502	1.6
LDTP01011	Protein diaphanous homolog 1 (DIAPH1)				C1227	1.6
LDTP04975	Small ribosomal subunit protein uS17 (RPS11)				C116	1.6
LDTP10864	Calponin-2 (CNN2)				C215	1.5
LDTP09549	Conserved oligomeric Golgi complex subunit 1 (COG1)				C513	1.5
LDTP04028	DNA mismatch repair protein Msh2 (MSH2)				C843	1.4
LDTP14337	Protein strawberry notch homolog 1 (SBNO1)				C445	1.4
LDTP04390	T-complex protein 1 subunit theta (CCT8)				C244	1.4
LDTP07947	Eukaryotic translation initiation factor 3 subunit M (EIF3M)				C134	1.4
LDTP12144	GrpE protein homolog 1, mitochondrial (GRPEL1)				C124	1.4
LDTP12669	Mediator of RNA polymerase II transcription subunit 17 (MED17)				C649	1.4
LDTP09580	Programmed cell death 6-interacting protein (PDCD6IP)				C250	1.4
LDTP01320	Eukaryotic translation initiation factor 3 subunit J (EIF3J)				C207	1.3
LDTP00756	Heterogeneous nuclear ribonucleoprotein R (HNRNPR)				C99	1.3
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C194	1.3
LDTP04902	Actin-related protein 3 (ACTR3)				C235	1.3
LDTP06366	Poly(rC)-binding protein 1 (PCBP1)				C109	1.3
LDTP03244	Cofilin-1 (CFL1)				C80	1.3
LDTP08573	Ankyrin repeat and KH domain-containing protein 1 (ANKHD1)				C615	1.3
LDTP13580	Coronin-1C (CORO1C)				C456	1.3
LDTP04117	Ras GTPase-activating-like protein IQGAP1 (IQGAP1)				C781	1.2
LDTP03695	Heat shock 70 kDa protein 4 (HSPA4)				C34	1.2
LDTP04201	T-complex protein 1 subunit epsilon (CCT5)				C253	1.2
LDTP11239	Protein misato homolog 1 (MSTO1)				C485	1.1
LDTP06268	Condensin complex subunit 2 (NCAPH)				C418	1.0
LDTP04514	Heterogeneous nuclear ribonucleoprotein F (HNRNPF)				C122	0.9

1	Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.