Details of the Target

General Information of Target

Target ID LDTP06281
Target Name Condensin complex subunit 1 (NCAPD2)
Gene Name NCAPD2
Gene ID 9918
Synonyms
CAPD2; CNAP1; KIAA0159; Condensin complex subunit 1; Chromosome condensation-related SMC-associated protein 1; Chromosome-associated protein D2; hCAP-D2; Non-SMC condensin I complex subunit D2; XCAP-D2 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPQMYEFHLPLSPEELLKSGGVNQYVVQEVLSIKHLPPQLRAFQAAFRAQGPLAMLQHF
DTIYSILHHFRSIDPGLKEDTLQFLIKVVSRHSQELPAILDDTTLSGSDRNAHLNALKMN
CYALIRLLESFETMASQTNLVDLDLGGKGKKARTKAAHGFDWEEERQPILQLLTQLLQLD
IRHLWNHSIIEEEFVSLVTGCCYRLLENPTINHQKNRPTREAITHLLGVALTRYNHMLSA
TVKIIQMLQHFEHLAPVLVAAVSLWATDYGMKSIVGEIVREIGQKCPQELSRDPSGTKGF
AAFLTELAERVPAILMSSMCILLDHLDGENYMMRNAVLAAMAEMVLQVLSGDQLEAAARD
TRDQFLDTLQAHGHDVNSFVRSRVLQLFTRIVQQKALPLTRFQAVVALAVGRLADKSVLV
CKNAIQLLASFLANNPFSCKLSDADLAGPLQKETQKLQEMRAQRRTAAASAVLDPEEEWE
AMLPELKSTLQQLLQLPQGEEEIPEQIANTETTEDVKGRIYQLLAKASYKKAIILTREAT
GHFQESEPFSHIDPEESEETRLLNILGLIFKGPAASTQEKNPRESTGNMVTGQTVCKNKP
NMSDPEESRGNDELVKQEMLVQYLQDAYSFSRKITEAIGIISKMMYENTTTVVQEVIEFF
VMVFQFGVPQALFGVRRMLPLIWSKEPGVREAVLNAYRQLYLNPKGDSARAKAQALIQNL
SLLLVDASVGTIQCLEEILCEFVQKDELKPAVTQLLWERATEKVACCPLERCSSVMLLGM
MARGKPEIVGSNLDTLVSIGLDEKFPQDYRLAQQVCHAIANISDRRKPSLGKRHPPFRLP
QEHRLFERLRETVTKGFVHPDPLWIPFKEVAVTLIYQLAEGPEVICAQILQGCAKQALEK
LEEKRTSQEDPKESPAMLPTFLLMNLLSLAGDVALQQLVHLEQAVSGELCRRRVLREEQE
HKTKDPKEKNTSSETTMEEELGLVGATADDTEAELIRGICEMELLDGKQTLAAFVPLLLK
VCNNPGLYSNPDLSAAASLALGKFCMISATFCDSQLRLLFTMLEKSPLPIVRSNLMVATG
DLAIRFPNLVDPWTPHLYARLRDPAQQVRKTAGLVMTHLILKDMVKVKGQVSEMAVLLID
PEPQIAALAKNFFNELSHKGNAIYNLLPDIISRLSDPELGVEEEPFHTIMKQLLSYITKD
KQTESLVEKLCQRFRTSRTERQQRDLAYCVSQLPLTERGLRKMLDNFDCFGDKLSDESIF
SAFLSVVGKLRRGAKPEGKAIIDEFEQKLRACHTRGLDGIKELEIGQAGSQRAPSAKKPS
TGSRYQPLASTASDNDFVTPEPRRTTRRHPNTQQRASKKKPKVVFSSDESSEEDLSAEMT
EDETPKKTTPILRASARRHRS
Target Bioclass
Other
Family
CND1 (condensin subunit 1) family
Subcellular location
Nucleus
Function
Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. May target the condensin complex to DNA via its C-terminal domain. May promote the resolution of double-strand DNA catenanes (intertwines) between sister chromatids. Condensin-mediated compaction likely increases tension in catenated sister chromatids, providing directionality for type II topoisomerase-mediated strand exchanges toward chromatid decatenation. Required for decatenation of non-centromeric ultrafine DNA bridges during anaphase. Early in neurogenesis, may play an essential role to ensure accurate mitotic chromosome condensation in neuron stem cells, ultimately affecting neuron pool and cortex size.
Uniprot ID
Q15021
Ensemble ID
ENST00000315579.10
HGNC ID
HGNC:24305

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 44 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		11.46  LDD0402  [1]
A-EBA
 Probe Info  		4.52  LDD0215  [2]
AZ-9
 Probe Info  		5.62  LDD0393  [3]
CY-1
 Probe Info  		100.00  LDD0243  [4]
CY4
 Probe Info  		100.00  LDD0244  [4]
TH211
 Probe Info  		Y122(10.04)  LDD0257  [5]
ONAyne
 Probe Info  		K416(0.85)  LDD0274  [6]
Probe 1
 Probe Info  		Y697(14.63); Y701(7.80)  LDD3495  [7]
BTD
 Probe Info  		C286(1.40); C596(0.70); C767(0.49)  LDD1700  [8]
Sulforaphane-probe2
 Probe Info  		3.60  LDD0042  [9]
DA-P3
 Probe Info  		4.89  LDD0182  [10]
AHL-Pu-1
 Probe Info  		C421(2.04); C596(3.31)  LDD0169  [11]
HHS-475
 Probe Info  		Y1325(1.25)  LDD0264  [12]
HHS-465
 Probe Info  		Y1164(1.27); Y1325(8.86)  LDD2237  [13]
DBIA
 Probe Info  		C439(1.25); C766(1.07); C767(1.07); C1045(1.03)  LDD0078  [14]
5E-2FA
 Probe Info  		N.A.  LDD2235  [15]
ATP probe
 Probe Info  		K1209(0.00); K1288(0.00); K452(0.00); K456(0.00)  LDD0199  [16]
4-Iodoacetamidophenylacetylene
 Probe Info  		C286(0.00); C1229(0.00); C596(0.00); C1000(0.00)  LDD0038  [17]
IA-alkyne
 Probe Info  		C596(0.00); C1229(0.00); C772(0.00)  LDD0032  [18]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [19]
Lodoacetamide azide
 Probe Info  		C286(0.00); C1229(0.00); C596(0.00); C1000(0.00)  LDD0037  [17]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [20]
NAIA_4
 Probe Info  		C439(0.00); C596(0.00); C767(0.00)  LDD2226  [21]
TFBX
 Probe Info  		C121(0.00); C286(0.00)  LDD0027  [20]
WYneN
 Probe Info  		C596(0.00); C767(0.00); C286(0.00)  LDD0021  [22]
WYneO
 Probe Info  		C286(0.00); C596(0.00)  LDD0022  [22]
Compound 10
 Probe Info  		C596(0.00); C767(0.00)  LDD2216  [23]
Compound 11
 Probe Info  		N.A.  LDD2213  [23]
ENE
 Probe Info  		C596(0.00); C767(0.00); C421(0.00)  LDD0006  [22]
IPM
 Probe Info  		C421(0.00); C286(0.00); C596(0.00); C767(0.00)  LDD0005  [22]
NPM
 Probe Info  		N.A.  LDD0016  [22]
PF-06672131
 Probe Info  		N.A.  LDD0017  [24]
PPMS
 Probe Info  		N.A.  LDD0008  [22]
SF
 Probe Info  		N.A.  LDD0028  [25]
STPyne
 Probe Info  		K395(0.00); K633(0.00); K763(0.00)  LDD0009  [22]
VSF
 Probe Info  		C286(0.00); C596(0.00)  LDD0007  [22]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [26]
1c-yne
 Probe Info  		K1122(0.00); K616(0.00); K456(0.00); K571(0.00)  LDD0228  [27]
Acrolein
 Probe Info  		C816(0.00); C596(0.00); C1229(0.00); H92(0.00)  LDD0217  [28]
Crotonaldehyde
 Probe Info  		C596(0.00); C1229(0.00); C766(0.00)  LDD0219  [28]
Methacrolein
 Probe Info  		C1229(0.00); C816(0.00); C766(0.00); C596(0.00)  LDD0218  [28]
W1
 Probe Info  		C1229(0.00); C766(0.00); C767(0.00); C596(0.00)  LDD0236  [29]
AOyne
 Probe Info  		9.90  LDD0443  [30]
NAIA_5
 Probe Info  		C772(0.00); C1229(0.00); C1000(0.00); C121(0.00)  LDD2223  [21]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		5.02  LDD0472  [31]
FFF probe13
 Probe Info  		13.32  LDD0475  [31]
FFF probe2
 Probe Info  		7.19  LDD0463  [31]
FFF probe3
 Probe Info  		8.32  LDD0464  [31]
STS-1
 Probe Info  		N.A.  LDD0137  [32]
STS-2
 Probe Info  		N.A.  LDD0138  [32]
VE-P
 Probe Info  		N.A.  LDD0396  [33]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C286(1.00)  LDD2112  [8]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C421(1.01); C286(1.01)  LDD2130  [8]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C421(1.19); C286(0.94); C596(0.92); C767(1.02)  LDD2117  [8]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C421(1.41); C766(1.32)  LDD2152  [8]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C286(1.00); C816(0.92)  LDD2103  [8]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C286(0.81)  LDD2132  [8]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C421(0.94); C286(0.87); C596(0.71)  LDD2131  [8]
 LDCM0025  4SU-RNA DM93 C421(3.65)  LDD0170  [11]
 LDCM0026  4SU-RNA+native RNA HEK-293T C421(2.04); C596(3.31)  LDD0169  [11]
 LDCM0214  AC1 HCT 116 C766(0.94); C767(1.02); C1229(1.23); C1000(1.06)  LDD0531  [14]
 LDCM0215  AC10 HCT 116 C766(0.93); C767(1.22); C1000(0.97); C1022(1.11)  LDD0532  [14]
 LDCM0216  AC100 HCT 116 C766(1.17); C767(1.07); C1229(0.36); C1000(0.79)  LDD0533  [14]
 LDCM0217  AC101 HCT 116 C766(0.74); C767(1.25); C1229(0.63); C1000(0.81)  LDD0534  [14]
 LDCM0218  AC102 HCT 116 C766(0.69); C767(0.79); C1229(0.35); C1000(0.74)  LDD0535  [14]
 LDCM0219  AC103 HCT 116 C766(0.55); C767(1.60); C1229(0.26); C1000(0.80)  LDD0536  [14]
 LDCM0220  AC104 HCT 116 C766(0.86); C767(1.54); C1229(0.30); C1000(0.81)  LDD0537  [14]
 LDCM0221  AC105 HCT 116 C766(0.95); C767(1.46); C1229(0.35); C1000(0.73)  LDD0538  [14]
 LDCM0222  AC106 HCT 116 C766(0.50); C767(1.37); C1229(0.25); C1000(0.77)  LDD0539  [14]
 LDCM0223  AC107 HCT 116 C766(0.71); C767(1.18); C1229(0.30); C1000(1.18)  LDD0540  [14]
 LDCM0224  AC108 HCT 116 C766(0.64); C767(0.81); C1229(0.46); C1000(0.95)  LDD0541  [14]
 LDCM0225  AC109 HCT 116 C766(0.80); C767(1.16); C1229(0.81); C1000(0.93)  LDD0542  [14]
 LDCM0226  AC11 HCT 116 C766(0.94); C767(1.27); C1000(1.00); C1022(0.90)  LDD0543  [14]
 LDCM0227  AC110 HCT 116 C766(0.58); C767(0.84); C1229(0.39); C1000(0.96)  LDD0544  [14]
 LDCM0228  AC111 HCT 116 C766(0.51); C767(0.87); C1229(0.38); C1000(0.92)  LDD0545  [14]
 LDCM0229  AC112 HCT 116 C766(0.72); C767(1.89); C1229(0.42); C1000(1.06)  LDD0546  [14]
 LDCM0230  AC113 HCT 116 C766(0.89); C767(1.04); C1229(0.97); C1000(0.92)  LDD0547  [14]
 LDCM0231  AC114 HCT 116 C766(0.94); C767(0.95); C1229(1.01); C1000(0.80)  LDD0548  [14]
 LDCM0232  AC115 HCT 116 C766(1.03); C767(1.00); C1229(0.84); C1000(0.79)  LDD0549  [14]
 LDCM0233  AC116 HCT 116 C766(2.58); C767(1.52); C1229(0.91); C1000(0.82)  LDD0550  [14]
 LDCM0234  AC117 HCT 116 C766(1.09); C767(1.08); C1229(1.11); C1000(0.80)  LDD0551  [14]
 LDCM0235  AC118 HCT 116 C766(1.02); C767(1.08); C1229(0.99); C1000(0.86)  LDD0552  [14]
 LDCM0236  AC119 HCT 116 C766(1.16); C767(1.16); C1229(1.00); C1000(0.87)  LDD0553  [14]
 LDCM0237  AC12 HCT 116 C766(1.10); C767(1.06); C1000(1.01); C1022(0.95)  LDD0554  [14]
 LDCM0238  AC120 HCT 116 C766(0.85); C767(1.03); C1229(0.94); C1000(0.83)  LDD0555  [14]
 LDCM0239  AC121 HCT 116 C766(1.01); C767(0.93); C1229(1.15); C1000(0.93)  LDD0556  [14]
 LDCM0240  AC122 HCT 116 C766(1.19); C767(1.00); C1229(0.97); C1000(0.94)  LDD0557  [14]
 LDCM0241  AC123 HCT 116 C766(1.09); C767(0.92); C1229(1.17); C1000(0.90)  LDD0558  [14]
 LDCM0242  AC124 HCT 116 C766(1.13); C767(0.99); C1229(1.19); C1000(0.85)  LDD0559  [14]
 LDCM0243  AC125 HCT 116 C766(1.04); C767(0.99); C1229(1.05); C1000(0.99)  LDD0560  [14]
 LDCM0244  AC126 HCT 116 C766(1.10); C767(1.05); C1229(1.18); C1000(1.10)  LDD0561  [14]
 LDCM0245  AC127 HCT 116 C766(1.18); C767(1.03); C1229(0.96); C1000(0.88)  LDD0562  [14]
 LDCM0246  AC128 HCT 116 C766(1.29); C767(1.29); C1229(1.07); C1045(1.23)  LDD0563  [14]
 LDCM0247  AC129 HCT 116 C766(1.25); C767(1.25); C1229(0.88); C1045(1.21)  LDD0564  [14]
 LDCM0249  AC130 HCT 116 C766(1.47); C767(1.47); C1229(0.91); C1045(1.20)  LDD0566  [14]
 LDCM0250  AC131 HCT 116 C766(1.23); C767(1.23); C1229(1.23); C1045(1.43)  LDD0567  [14]
 LDCM0251  AC132 HCT 116 C766(1.59); C767(1.59); C1229(1.32); C1045(1.35)  LDD0568  [14]
 LDCM0252  AC133 HCT 116 C766(1.31); C767(1.31); C1229(1.23); C1045(1.23)  LDD0569  [14]
 LDCM0253  AC134 HCT 116 C766(1.41); C767(1.41); C1229(1.41); C1045(1.06)  LDD0570  [14]
 LDCM0254  AC135 HCT 116 C766(1.29); C767(1.29); C1229(0.91); C1045(1.26)  LDD0571  [14]
 LDCM0255  AC136 HCT 116 C766(1.20); C767(1.20); C1229(0.96); C1045(1.15)  LDD0572  [14]
 LDCM0256  AC137 HCT 116 C766(1.40); C767(1.40); C1229(1.15); C1045(1.24)  LDD0573  [14]
 LDCM0257  AC138 HCT 116 C766(2.06); C767(2.06); C1229(1.09); C1045(1.44)  LDD0574  [14]
 LDCM0258  AC139 HCT 116 C766(1.49); C767(1.49); C1229(0.90); C1045(1.32)  LDD0575  [14]
 LDCM0259  AC14 HCT 116 C766(0.77); C767(1.15); C1000(1.02); C1022(1.16)  LDD0576  [14]
 LDCM0260  AC140 HCT 116 C766(1.81); C767(1.81); C1229(0.91); C1045(1.28)  LDD0577  [14]
 LDCM0261  AC141 HCT 116 C766(1.56); C767(1.56); C1229(0.92); C1045(1.19)  LDD0578  [14]
 LDCM0262  AC142 HCT 116 C766(1.48); C767(1.48); C1229(1.19); C1045(1.14)  LDD0579  [14]
 LDCM0263  AC143 HCT 116 C766(1.13); C767(1.14); C1229(0.83); C1000(0.71)  LDD0580  [14]
 LDCM0264  AC144 HCT 116 C1229(0.41); C1249(0.74); C121(0.76); C1000(0.85)  LDD0581  [14]
 LDCM0265  AC145 HCT 116 C1229(0.58); C1249(0.87); C121(0.92); C1000(0.93)  LDD0582  [14]
 LDCM0266  AC146 HCT 116 C1229(0.51); C1249(0.82); C286(0.89); C121(0.92)  LDD0583  [14]
 LDCM0267  AC147 HCT 116 C1229(0.43); C1249(0.74); C1045(0.87); C1052(0.90)  LDD0584  [14]
 LDCM0268  AC148 HCT 116 C1229(0.47); C1249(0.84); C1000(0.97); C286(1.04)  LDD0585  [14]
 LDCM0269  AC149 HCT 116 C1229(0.48); C1249(0.82); C1045(0.92); C1052(0.97)  LDD0586  [14]
 LDCM0270  AC15 HCT 116 C1022(0.88); C816(0.92); C1000(0.95); C766(0.96)  LDD0587  [14]
 LDCM0271  AC150 HCT 116 C1229(0.66); C1249(0.86); C772(0.91); C1000(0.98)  LDD0588  [14]
 LDCM0272  AC151 HCT 116 C1229(0.74); C1249(0.85); C767(1.00); C1045(1.03)  LDD0589  [14]
 LDCM0273  AC152 HCT 116 C1229(0.42); C1249(0.70); C772(0.94); C1052(1.00)  LDD0590  [14]
 LDCM0274  AC153 HCT 116 C1229(0.51); C1249(0.96); C286(0.98); C772(0.99)  LDD0591  [14]
 LDCM0621  AC154 HCT 116 C766(1.10); C767(0.98); C1229(0.50); C1000(1.01)  LDD2158  [14]
 LDCM0622  AC155 HCT 116 C766(1.02); C767(0.86); C1229(0.50); C1000(1.08)  LDD2159  [14]
 LDCM0623  AC156 HCT 116 C766(0.91); C767(0.84); C1229(0.93); C1000(1.11)  LDD2160  [14]
 LDCM0624  AC157 HCT 116 C766(0.87); C767(0.76); C1229(0.80); C1000(1.13)  LDD2161  [14]
 LDCM0276  AC17 HCT 116 C121(0.62); C1229(0.81); C1249(0.83); C596(0.88)  LDD0593  [14]
 LDCM0277  AC18 HCT 116 C121(0.66); C1249(0.72); C1022(0.73); C1229(0.82)  LDD0594  [14]
 LDCM0278  AC19 HCT 116 C1229(0.79); C1249(0.79); C596(0.82); C286(0.85)  LDD0595  [14]
 LDCM0279  AC2 HCT 116 C121(0.63); C1022(0.89); C1045(0.90); C1052(0.90)  LDD0596  [14]
 LDCM0280  AC20 HCT 116 C1229(0.81); C1249(0.82); C1000(0.84); C596(0.89)  LDD0597  [14]
 LDCM0281  AC21 HCT 116 C1022(0.70); C1249(0.82); C121(0.86); C1045(0.86)  LDD0598  [14]
 LDCM0282  AC22 HCT 116 C121(0.81); C596(0.81); C1249(0.86); C1000(0.92)  LDD0599  [14]
 LDCM0283  AC23 HCT 116 C1249(0.85); C1045(0.92); C1229(0.92); C772(0.92)  LDD0600  [14]
 LDCM0284  AC24 HCT 116 C596(0.73); C121(0.88); C1249(0.88); C772(0.93)  LDD0601  [14]
 LDCM0285  AC25 HCT 116 C766(0.84); C1229(0.86); C1000(0.87); C1052(0.91)  LDD0602  [14]
 LDCM0286  AC26 HCT 116 C1229(0.81); C1249(0.83); C766(0.84); C1022(0.89)  LDD0603  [14]
 LDCM0287  AC27 HCT 116 C766(0.80); C1052(0.81); C286(0.81); C1022(0.83)  LDD0604  [14]
 LDCM0288  AC28 HCT 116 C286(0.79); C1022(0.79); C1229(0.87); C1052(0.87)  LDD0605  [14]
 LDCM0289  AC29 HCT 116 C1229(0.71); C1249(0.81); C1022(0.85); C816(0.88)  LDD0606  [14]
 LDCM0290  AC3 HCT 116 C121(0.60); C1022(0.89); C1045(0.91); C1052(0.91)  LDD0607  [14]
 LDCM0291  AC30 HCT 116 C1229(0.70); C1249(0.80); C766(0.82); C1022(0.84)  LDD0608  [14]
 LDCM0292  AC31 HCT 116 C1022(0.72); C1249(0.79); C1229(0.81); C766(0.86)  LDD0609  [14]
 LDCM0293  AC32 HCT 116 C766(0.73); C1022(0.74); C1229(0.79); C1249(0.80)  LDD0610  [14]
 LDCM0294  AC33 HCT 116 C1229(0.71); C1022(0.73); C1249(0.74); C766(0.82)  LDD0611  [14]
 LDCM0295  AC34 HCT 116 C1229(0.63); C1249(0.75); C766(0.81); C1022(0.83)  LDD0612  [14]
 LDCM0296  AC35 HCT 116 C1000(0.80); C767(0.87); C286(0.90); C596(0.90)  LDD0613  [14]
 LDCM0297  AC36 HCT 116 C121(0.84); C1000(0.90); C596(0.93); C1022(0.93)  LDD0614  [14]
 LDCM0298  AC37 HCT 116 C1229(0.75); C1000(0.78); C767(0.84); C439(0.85)  LDD0615  [14]
 LDCM0299  AC38 HCT 116 C1000(0.92); C121(0.94); C596(0.94); C767(0.95)  LDD0616  [14]
 LDCM0300  AC39 HCT 116 C1022(0.89); C1229(0.91); C1000(0.91); C121(0.94)  LDD0617  [14]
 LDCM0301  AC4 HCT 116 C121(0.63); C1022(0.74); C1045(0.80); C1052(0.80)  LDD0618  [14]
 LDCM0302  AC40 HCT 116 C1229(0.72); C1000(0.82); C121(0.85); C1022(0.91)  LDD0619  [14]
 LDCM0303  AC41 HCT 116 C1229(0.81); C1022(0.86); C121(0.86); C439(0.88)  LDD0620  [14]
 LDCM0304  AC42 HCT 116 C1022(0.92); C1229(0.94); C1249(0.97); C121(1.01)  LDD0621  [14]
 LDCM0305  AC43 HCT 116 C1000(0.89); C121(0.98); C1022(0.99); C1045(1.00)  LDD0622  [14]
 LDCM0306  AC44 HCT 116 C1229(0.73); C1000(0.86); C121(0.88); C1022(0.93)  LDD0623  [14]
 LDCM0307  AC45 HCT 116 C1229(0.79); C121(0.89); C1022(0.91); C1249(0.95)  LDD0624  [14]
 LDCM0308  AC46 HCT 116 C286(0.95); C121(0.95); C1000(0.95); C816(0.97)  LDD0625  [14]
 LDCM0309  AC47 HCT 116 C1229(0.82); C286(0.91); C121(0.92); C1022(0.93)  LDD0626  [14]
 LDCM0310  AC48 HCT 116 C439(0.77); C286(0.89); C596(0.96); C816(0.96)  LDD0627  [14]
 LDCM0311  AC49 HCT 116 C1229(0.94); C1249(0.95); C286(0.97); C772(1.01)  LDD0628  [14]
 LDCM0312  AC5 HCT 116 C121(0.70); C1022(0.73); C1045(0.88); C1052(0.88)  LDD0629  [14]
 LDCM0313  AC50 HCT 116 C286(0.92); C816(0.97); C439(1.01); C1249(1.01)  LDD0630  [14]
 LDCM0314  AC51 HCT 116 C439(0.88); C286(0.88); C596(0.90); C1229(0.95)  LDD0631  [14]
 LDCM0315  AC52 HCT 116 C439(0.74); C1229(0.77); C121(0.87); C1000(0.97)  LDD0632  [14]
 LDCM0316  AC53 HCT 116 C439(0.86); C816(0.89); C1249(0.90); C1229(0.94)  LDD0633  [14]
 LDCM0317  AC54 HCT 116 C439(0.70); C1229(0.94); C286(0.94); C1249(0.95)  LDD0634  [14]
 LDCM0318  AC55 HCT 116 C1229(0.85); C439(0.86); C1249(0.94); C816(0.98)  LDD0635  [14]
 LDCM0319  AC56 HCT 116 C439(0.93); C1229(0.98); C816(0.98); C121(1.02)  LDD0636  [14]
 LDCM0320  AC57 HCT 116 C1229(0.48); C1000(0.77); C1249(0.82); C286(0.91)  LDD0637  [14]
 LDCM0321  AC58 HCT 116 C1229(0.51); C1249(0.79); C286(0.81); C766(0.92)  LDD0638  [14]
 LDCM0322  AC59 HCT 116 C1229(0.46); C1249(0.78); C286(0.85); C766(0.86)  LDD0639  [14]
 LDCM0323  AC6 HCT 116 C1045(0.86); C1052(0.87); C1000(0.88); C1249(0.92)  LDD0640  [14]
 LDCM0324  AC60 HCT 116 C1229(0.46); C1249(0.77); C286(0.81); C1000(0.89)  LDD0641  [14]
 LDCM0325  AC61 HCT 116 C1229(0.61); C286(0.86); C1052(0.95); C1249(0.95)  LDD0642  [14]
 LDCM0326  AC62 HCT 116 C1229(0.52); C1249(0.81); C286(0.86); C766(0.96)  LDD0643  [14]
 LDCM0327  AC63 HCT 116 C1229(0.50); C1249(0.78); C1000(0.82); C1052(0.90)  LDD0644  [14]
 LDCM0328  AC64 HCT 116 C1229(0.52); C1249(0.81); C286(0.83); C766(0.95)  LDD0645  [14]
 LDCM0329  AC65 HCT 116 C1229(0.49); C1249(0.82); C766(0.88); C286(0.94)  LDD0646  [14]
 LDCM0330  AC66 HCT 116 C1229(0.48); C1249(0.83); C286(0.85); C766(0.98)  LDD0647  [14]
 LDCM0331  AC67 HCT 116 C1229(0.45); C1249(0.77); C286(0.86); C766(0.97)  LDD0648  [14]
 LDCM0332  AC68 HCT 116 C121(0.81); C1249(0.85); C286(0.92); C767(0.94)  LDD0649  [14]
 LDCM0333  AC69 HCT 116 C286(0.85); C1249(0.86); C1229(0.87); C767(0.88)  LDD0650  [14]
 LDCM0334  AC7 HCT 116 C816(0.82); C1052(0.93); C1000(0.96); C1045(0.97)  LDD0651  [14]
 LDCM0335  AC70 HCT 116 C1229(0.66); C816(0.76); C1249(0.89); C121(0.91)  LDD0652  [14]
 LDCM0336  AC71 HCT 116 C286(0.76); C121(0.87); C1052(0.97); C767(0.97)  LDD0653  [14]
 LDCM0337  AC72 HCT 116 C1229(0.75); C1249(0.85); C121(0.87); C286(0.87)  LDD0654  [14]
 LDCM0338  AC73 HCT 116 C1229(0.80); C286(0.89); C1249(0.90); C121(1.03)  LDD0655  [14]
 LDCM0339  AC74 HCT 116 C286(0.70); C816(0.82); C1249(0.87); C767(1.00)  LDD0656  [14]
 LDCM0340  AC75 HCT 116 C816(0.83); C286(0.85); C1229(0.89); C121(0.97)  LDD0657  [14]
 LDCM0341  AC76 HCT 116 C286(0.67); C1249(0.86); C121(0.86); C816(0.91)  LDD0658  [14]
 LDCM0342  AC77 HCT 116 C286(0.71); C1229(0.82); C816(0.86); C121(0.86)  LDD0659  [14]
 LDCM0343  AC78 HCT 116 C286(0.79); C439(0.91); C1052(0.92); C121(0.95)  LDD0660  [14]
 LDCM0344  AC79 HCT 116 C286(0.73); C1249(0.84); C766(0.86); C1229(0.94)  LDD0661  [14]
 LDCM0345  AC8 HCT 116 C766(0.81); C1022(0.87); C1045(0.88); C1052(0.91)  LDD0662  [14]
 LDCM0346  AC80 HCT 116 C286(0.72); C766(0.80); C1229(0.87); C816(0.88)  LDD0663  [14]
 LDCM0347  AC81 HCT 116 C286(0.78); C439(0.79); C772(0.85); C816(0.89)  LDD0664  [14]
 LDCM0348  AC82 HCT 116 C286(0.78); C121(0.87); C1229(0.92); C816(0.96)  LDD0665  [14]
 LDCM0349  AC83 HCT 116 C1229(0.57); C1249(0.69); C1045(0.93); C772(0.94)  LDD0666  [14]
 LDCM0350  AC84 HCT 116 C1229(0.53); C1249(0.68); C1045(0.97); C766(1.05)  LDD0667  [14]
 LDCM0351  AC85 HCT 116 C1229(0.66); C1249(0.81); C1045(0.81); C1052(0.84)  LDD0668  [14]
 LDCM0352  AC86 HCT 116 C1229(0.64); C1249(0.78); C1045(0.90); C1052(0.94)  LDD0669  [14]
 LDCM0353  AC87 HCT 116 C1045(0.79); C1052(0.88); C1229(0.96); C772(1.00)  LDD0670  [14]
 LDCM0354  AC88 HCT 116 C1229(0.69); C1045(0.78); C1052(0.83); C1249(0.85)  LDD0671  [14]
 LDCM0355  AC89 HCT 116 C1229(0.58); C1249(0.73); C772(0.97); C1045(0.97)  LDD0672  [14]
 LDCM0357  AC90 HCT 116 C1045(0.86); C1052(0.88); C772(0.89); C596(0.98)  LDD0674  [14]
 LDCM0358  AC91 HCT 116 C1229(0.50); C1249(0.73); C1045(0.82); C286(0.92)  LDD0675  [14]
 LDCM0359  AC92 HCT 116 C1229(0.48); C1249(0.74); C1045(0.82); C772(0.83)  LDD0676  [14]
 LDCM0360  AC93 HCT 116 C1229(0.62); C1249(0.71); C1045(0.85); C1000(0.86)  LDD0677  [14]
 LDCM0361  AC94 HCT 116 C1229(0.69); C772(0.78); C1045(0.81); C1249(0.82)  LDD0678  [14]
 LDCM0362  AC95 HCT 116 C1229(0.75); C1045(0.80); C1052(0.86); C1249(0.88)  LDD0679  [14]
 LDCM0363  AC96 HCT 116 C1229(0.50); C1249(0.75); C1045(0.81); C286(0.85)  LDD0680  [14]
 LDCM0364  AC97 HCT 116 C1229(0.49); C1249(0.71); C772(0.81); C1045(0.84)  LDD0681  [14]
 LDCM0365  AC98 HCT 116 C1229(0.26); C1249(0.61); C816(0.67); C1052(0.68)  LDD0682  [14]
 LDCM0366  AC99 HCT 116 C1229(0.47); C766(0.67); C816(0.68); C1045(0.72)  LDD0683  [14]
 LDCM0545  Acetamide MDA-MB-231 C421(0.48); C286(0.37)  LDD2138  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C286(0.48); C766(1.00)  LDD2113  [8]
 LDCM0248  AKOS034007472 HCT 116 C766(0.96); C767(1.16); C1000(0.98); C1022(1.55)  LDD0565  [14]
 LDCM0356  AKOS034007680 HCT 116 C816(0.87); C1045(0.90); C1000(0.93); C1052(0.95)  LDD0673  [14]
 LDCM0275  AKOS034007705 HCT 116 C1022(0.74); C766(0.90); C1249(0.92); C816(0.93)  LDD0592  [14]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C439(1.25); C766(1.07); C767(1.07); C1045(1.03)  LDD0078  [14]
 LDCM0102  BDHI 8 Jurkat C121(37.59)  LDD0204  [34]
 LDCM0498  BS-3668 MDA-MB-231 C286(0.62)  LDD2091  [8]
 LDCM0630  CCW28-3 231MFP C439(1.39)  LDD2214  [35]
 LDCM0108  Chloroacetamide HeLa C816(0.00); C1229(0.00); C596(0.00); C1249(0.00)  LDD0222  [28]
 LDCM0632  CL-Sc Hep-G2 C596(20.00); C772(0.73); C816(0.62)  LDD2227  [21]
 LDCM0367  CL1 HCT 116 C1022(0.72); C816(1.00); C1000(1.03); C772(1.05)  LDD0684  [14]
 LDCM0368  CL10 HCT 116 C1022(0.81); C772(0.92); C816(0.92); C1249(1.08)  LDD0685  [14]
 LDCM0369  CL100 HCT 116 C121(0.78); C1022(0.80); C1045(0.86); C1052(0.86)  LDD0686  [14]
 LDCM0370  CL101 HCT 116 C286(0.86); C816(0.90); C1045(0.91); C1022(0.92)  LDD0687  [14]
 LDCM0371  CL102 HCT 116 C816(0.84); C286(0.93); C439(0.94); C1249(1.00)  LDD0688  [14]
 LDCM0372  CL103 HCT 116 C286(0.81); C816(0.81); C766(0.87); C1045(1.04)  LDD0689  [14]
 LDCM0373  CL104 HCT 116 C286(0.81); C1022(0.85); C816(0.85); C766(0.94)  LDD0690  [14]
 LDCM0374  CL105 HCT 116 C1022(0.67); C121(0.80); C1249(0.80); C772(0.83)  LDD0691  [14]
 LDCM0375  CL106 HCT 116 C1022(0.72); C1249(0.77); C772(0.85); C1045(0.87)  LDD0692  [14]
 LDCM0376  CL107 HCT 116 C1249(0.73); C1022(0.79); C772(0.84); C1229(0.85)  LDD0693  [14]
 LDCM0377  CL108 HCT 116 C1249(0.72); C772(0.83); C121(0.83); C1229(0.87)  LDD0694  [14]
 LDCM0378  CL109 HCT 116 C1229(0.71); C1249(0.78); C1022(0.80); C1045(0.93)  LDD0695  [14]
 LDCM0379  CL11 HCT 116 C1022(0.79); C816(0.90); C772(0.93); C1249(1.04)  LDD0696  [14]
 LDCM0380  CL110 HCT 116 C1249(0.77); C1022(0.79); C1045(0.96); C286(1.00)  LDD0697  [14]
 LDCM0381  CL111 HCT 116 C1229(0.79); C1249(0.80); C1022(0.88); C772(0.92)  LDD0698  [14]
 LDCM0382  CL112 HCT 116 C772(0.81); C1229(0.88); C1249(0.93); C1022(0.94)  LDD0699  [14]
 LDCM0383  CL113 HCT 116 C1249(0.77); C1229(0.80); C1022(0.84); C766(0.85)  LDD0700  [14]
 LDCM0384  CL114 HCT 116 C1229(0.86); C1000(0.91); C1249(0.92); C816(0.95)  LDD0701  [14]
 LDCM0385  CL115 HCT 116 C1022(0.79); C1229(0.79); C1249(0.80); C816(0.84)  LDD0702  [14]
 LDCM0386  CL116 HCT 116 C1022(0.78); C766(0.78); C1052(0.85); C1229(0.86)  LDD0703  [14]
 LDCM0387  CL117 HCT 116 C1000(1.01); C1249(1.05); C772(1.12); C1022(1.13)  LDD0704  [14]
 LDCM0388  CL118 HCT 116 C1229(0.86); C121(0.87); C1000(0.91); C1052(0.95)  LDD0705  [14]
 LDCM0389  CL119 HCT 116 C121(0.74); C1229(0.79); C1000(0.87); C1249(0.94)  LDD0706  [14]
 LDCM0390  CL12 HCT 116 C816(0.88); C1022(0.88); C772(0.90); C1249(0.96)  LDD0707  [14]
 LDCM0391  CL120 HCT 116 C1229(0.83); C1022(0.88); C121(0.89); C1000(0.95)  LDD0708  [14]
 LDCM0392  CL121 HCT 116 C439(0.67); C286(0.85); C596(0.91); C772(0.94)  LDD0709  [14]
 LDCM0393  CL122 HCT 116 C439(0.69); C121(0.83); C286(0.89); C816(0.93)  LDD0710  [14]
 LDCM0394  CL123 HCT 116 C439(0.59); C816(0.83); C1229(0.88); C121(0.98)  LDD0711  [14]
 LDCM0395  CL124 HCT 116 C439(0.69); C1229(0.82); C286(0.92); C1249(0.95)  LDD0712  [14]
 LDCM0396  CL125 HCT 116 C1229(0.70); C1249(0.96); C286(0.96); C772(1.06)  LDD0713  [14]
 LDCM0397  CL126 HCT 116 C1229(0.65); C1249(0.87); C286(0.93); C772(1.01)  LDD0714  [14]
 LDCM0398  CL127 HCT 116 C1229(0.76); C286(0.86); C1249(0.90); C1000(0.91)  LDD0715  [14]
 LDCM0399  CL128 HCT 116 C1229(0.48); C1249(0.80); C286(0.85); C1000(0.95)  LDD0716  [14]
 LDCM0400  CL13 HCT 116 C1022(0.66); C816(0.85); C1249(0.97); C1000(1.01)  LDD0717  [14]
 LDCM0401  CL14 HCT 116 C286(0.97); C1022(1.01); C1000(1.02); C1249(1.06)  LDD0718  [14]
 LDCM0402  CL15 HCT 116 C1022(0.78); C816(0.78); C1249(1.11); C1052(1.21)  LDD0719  [14]
 LDCM0403  CL16 HCT 116 C1249(0.87); C1000(0.92); C772(0.97); C1045(1.01)  LDD0720  [14]
 LDCM0404  CL17 HCT 116 C816(0.73); C1249(0.83); C1000(0.94); C1045(1.06)  LDD0721  [14]
 LDCM0405  CL18 HCT 116 C1045(0.82); C1052(0.85); C816(0.86); C1249(0.86)  LDD0722  [14]
 LDCM0406  CL19 HCT 116 C766(0.80); C816(0.82); C1249(0.83); C1045(0.90)  LDD0723  [14]
 LDCM0407  CL2 HCT 116 C1022(0.80); C816(0.98); C596(0.99); C1000(1.00)  LDD0724  [14]
 LDCM0408  CL20 HCT 116 C766(0.70); C816(0.79); C1249(0.83); C1229(0.86)  LDD0725  [14]
 LDCM0409  CL21 HCT 116 C816(0.92); C1249(0.95); C286(1.06); C1229(1.13)  LDD0726  [14]
 LDCM0410  CL22 HCT 116 C816(0.76); C1249(0.93); C766(0.96); C286(1.03)  LDD0727  [14]
 LDCM0411  CL23 HCT 116 C816(0.41); C766(0.79); C1249(0.79); C1000(0.83)  LDD0728  [14]
 LDCM0412  CL24 HCT 116 C766(0.68); C816(0.79); C1249(0.87); C1045(1.02)  LDD0729  [14]
 LDCM0413  CL25 HCT 116 C766(1.97); C767(2.41); C1229(1.36); C1000(1.01)  LDD0730  [14]
 LDCM0414  CL26 HCT 116 C766(0.80); C767(1.14); C1229(1.14); C1000(0.91)  LDD0731  [14]
 LDCM0415  CL27 HCT 116 C766(0.92); C767(1.24); C1229(1.29); C1000(1.12)  LDD0732  [14]
 LDCM0416  CL28 HCT 116 C766(2.32); C767(2.09); C1229(0.97); C1000(0.87)  LDD0733  [14]
 LDCM0417  CL29 HCT 116 C766(0.74); C767(1.07); C1229(0.97); C1000(0.94)  LDD0734  [14]
 LDCM0418  CL3 HCT 116 C766(3.16); C767(2.01); C1229(1.30); C1000(1.04)  LDD0735  [14]
 LDCM0419  CL30 HCT 116 C766(0.83); C767(1.15); C1229(1.15); C1000(0.96)  LDD0736  [14]
 LDCM0420  CL31 HCT 116 C766(1.89); C767(1.42); C1229(1.04); C1000(0.95)  LDD0737  [14]
 LDCM0421  CL32 HCT 116 C766(1.02); C767(0.98); C1229(0.85); C1000(0.83)  LDD0738  [14]
 LDCM0422  CL33 HCT 116 C766(0.87); C767(1.06); C1229(0.90); C1000(1.05)  LDD0739  [14]
 LDCM0423  CL34 HCT 116 C766(0.81); C767(1.05); C1229(0.86); C1000(1.09)  LDD0740  [14]
 LDCM0424  CL35 HCT 116 C766(0.86); C767(0.99); C1229(0.79); C1000(0.86)  LDD0741  [14]
 LDCM0425  CL36 HCT 116 C766(0.68); C767(1.01); C1229(0.90); C1000(0.93)  LDD0742  [14]
 LDCM0426  CL37 HCT 116 C766(0.76); C767(0.94); C1229(0.90); C1000(1.11)  LDD0743  [14]
 LDCM0428  CL39 HCT 116 C766(0.87); C767(1.01); C1229(1.08); C1000(0.97)  LDD0745  [14]
 LDCM0429  CL4 HCT 116 C766(2.89); C767(1.53); C1229(1.00); C1000(1.03)  LDD0746  [14]
 LDCM0430  CL40 HCT 116 C766(0.76); C767(1.22); C1229(0.95); C1000(0.79)  LDD0747  [14]
 LDCM0431  CL41 HCT 116 C766(0.91); C767(1.11); C1229(0.90); C1000(0.80)  LDD0748  [14]
 LDCM0432  CL42 HCT 116 C766(0.83); C767(1.05); C1229(0.87); C1000(1.34)  LDD0749  [14]
 LDCM0433  CL43 HCT 116 C766(0.83); C767(0.94); C1229(0.78); C1000(1.00)  LDD0750  [14]
 LDCM0434  CL44 HCT 116 C766(1.02); C767(0.94); C1229(1.07); C1000(1.08)  LDD0751  [14]
 LDCM0435  CL45 HCT 116 C766(0.76); C767(1.01); C1229(0.92); C1000(1.18)  LDD0752  [14]
 LDCM0436  CL46 HCT 116 C766(1.61); C767(1.44); C1229(1.81); C1000(1.10)  LDD0753  [14]
 LDCM0437  CL47 HCT 116 C766(1.23); C767(1.04); C1229(1.39); C1000(1.01)  LDD0754  [14]
 LDCM0438  CL48 HCT 116 C766(1.65); C767(1.43); C1229(1.11); C1000(0.94)  LDD0755  [14]
 LDCM0439  CL49 HCT 116 C766(2.48); C767(1.79); C1229(1.05); C1000(1.01)  LDD0756  [14]
 LDCM0440  CL5 HCT 116 C766(1.04); C767(0.96); C1229(1.21); C1000(0.98)  LDD0757  [14]
 LDCM0441  CL50 HCT 116 C766(1.52); C767(1.31); C1229(1.85); C1000(0.98)  LDD0758  [14]
 LDCM0442  CL51 HCT 116 C766(0.94); C767(1.23); C1229(1.51); C1000(1.07)  LDD0759  [14]
 LDCM0443  CL52 HCT 116 C766(1.76); C767(1.56); C1229(1.39); C1000(1.00)  LDD0760  [14]
 LDCM0444  CL53 HCT 116 C766(3.47); C767(2.39); C1229(0.95); C1000(1.02)  LDD0761  [14]
 LDCM0445  CL54 HCT 116 C766(2.49); C767(1.76); C1229(2.72); C1000(1.06)  LDD0762  [14]
 LDCM0446  CL55 HCT 116 C766(0.94); C767(0.92); C1229(2.24); C1000(1.05)  LDD0763  [14]
 LDCM0447  CL56 HCT 116 C766(1.12); C767(1.16); C1229(1.08); C1000(0.98)  LDD0764  [14]
 LDCM0448  CL57 HCT 116 C766(2.46); C767(1.80); C1229(3.24); C1000(1.05)  LDD0765  [14]
 LDCM0449  CL58 HCT 116 C766(1.03); C767(1.02); C1229(1.84); C1000(0.92)  LDD0766  [14]
 LDCM0450  CL59 HCT 116 C766(2.46); C767(1.78); C1229(1.24); C1000(1.01)  LDD0767  [14]
 LDCM0451  CL6 HCT 116 C766(1.81); C767(1.78); C1229(1.28); C1000(1.06)  LDD0768  [14]
 LDCM0452  CL60 HCT 116 C766(1.74); C767(1.46); C1229(0.94); C1000(0.97)  LDD0769  [14]
 LDCM0453  CL61 HCT 116 C766(1.28); C767(1.19); C1229(0.99); C1000(0.96)  LDD0770  [14]
 LDCM0454  CL62 HCT 116 C766(1.04); C767(1.22); C1229(0.88); C1000(0.89)  LDD0771  [14]
 LDCM0455  CL63 HCT 116 C766(1.15); C767(1.83); C1229(0.82); C1000(0.94)  LDD0772  [14]
 LDCM0456  CL64 HCT 116 C766(1.28); C767(4.62); C1229(0.78); C1000(1.04)  LDD0773  [14]
 LDCM0457  CL65 HCT 116 C766(2.65); C767(1.47); C1229(0.84); C1000(0.92)  LDD0774  [14]
 LDCM0458  CL66 HCT 116 C766(0.97); C767(2.72); C1229(0.81); C1000(1.21)  LDD0775  [14]
 LDCM0459  CL67 HCT 116 C766(1.46); C767(1.44); C1229(0.75); C1000(0.95)  LDD0776  [14]
 LDCM0460  CL68 HCT 116 C766(1.01); C767(3.36); C1229(1.03); C1000(0.95)  LDD0777  [14]
 LDCM0461  CL69 HCT 116 C766(1.72); C767(2.78); C1229(0.94); C1000(0.85)  LDD0778  [14]
 LDCM0462  CL7 HCT 116 C766(1.44); C767(1.57); C1229(1.01); C1000(1.08)  LDD0779  [14]
 LDCM0463  CL70 HCT 116 C766(1.56); C767(1.36); C1229(0.88); C1000(0.97)  LDD0780  [14]
 LDCM0464  CL71 HCT 116 C766(1.05); C767(1.66); C1229(0.79); C1000(0.88)  LDD0781  [14]
 LDCM0465  CL72 HCT 116 C766(1.31); C767(1.28); C1229(0.82); C1000(0.95)  LDD0782  [14]
 LDCM0466  CL73 HCT 116 C766(0.99); C767(2.22); C1229(0.77); C1000(0.87)  LDD0783  [14]
 LDCM0467  CL74 HCT 116 C766(1.54); C767(1.60); C1229(0.90); C1000(0.92)  LDD0784  [14]
 LDCM0469  CL76 HCT 116 C766(1.02); C767(1.08); C1000(0.98); C1022(0.96)  LDD0786  [14]
 LDCM0470  CL77 HCT 116 C766(0.86); C767(1.51); C1000(0.94); C1022(1.37)  LDD0787  [14]
 LDCM0471  CL78 HCT 116 C766(2.54); C767(1.47); C1000(0.98); C1022(0.76)  LDD0788  [14]
 LDCM0472  CL79 HCT 116 C766(0.79); C767(1.16); C1000(0.95); C1022(0.92)  LDD0789  [14]
 LDCM0473  CL8 HCT 116 C766(9.14); C767(6.47); C1229(1.19); C1000(1.28)  LDD0790  [14]
 LDCM0474  CL80 HCT 116 C766(0.88); C767(1.09); C1000(0.98); C1022(1.17)  LDD0791  [14]
 LDCM0475  CL81 HCT 116 C766(0.89); C767(1.24); C1000(0.98); C1022(0.84)  LDD0792  [14]
 LDCM0476  CL82 HCT 116 C766(0.87); C767(1.11); C1000(1.11); C1022(0.90)  LDD0793  [14]
 LDCM0477  CL83 HCT 116 C766(1.92); C767(1.88); C1000(1.17); C1022(0.96)  LDD0794  [14]
 LDCM0478  CL84 HCT 116 C766(1.63); C767(1.54); C1000(1.48); C1022(1.18)  LDD0795  [14]
 LDCM0479  CL85 HCT 116 C766(1.07); C767(1.08); C1000(0.98); C1022(0.88)  LDD0796  [14]
 LDCM0480  CL86 HCT 116 C766(1.58); C767(1.20); C1000(0.94); C1022(0.89)  LDD0797  [14]
 LDCM0481  CL87 HCT 116 C766(1.08); C767(1.16); C1000(1.04); C1022(0.89)  LDD0798  [14]
 LDCM0482  CL88 HCT 116 C766(0.88); C767(0.89); C1000(1.16); C1022(0.91)  LDD0799  [14]
 LDCM0483  CL89 HCT 116 C766(1.17); C767(1.01); C1000(1.58); C1022(1.33)  LDD0800  [14]
 LDCM0484  CL9 HCT 116 C766(1.89); C767(2.05); C1229(1.08); C1000(0.88)  LDD0801  [14]
 LDCM0485  CL90 HCT 116 C766(2.41); C767(2.01); C1000(1.30); C1022(1.42)  LDD0802  [14]
 LDCM0486  CL91 HCT 116 C766(1.19); C767(1.34); C1229(0.93); C1000(1.02)  LDD0803  [14]
 LDCM0487  CL92 HCT 116 C766(4.91); C767(3.01); C1229(0.96); C1000(1.28)  LDD0804  [14]
 LDCM0488  CL93 HCT 116 C766(3.05); C767(2.04); C1229(1.04); C1000(1.07)  LDD0805  [14]
 LDCM0489  CL94 HCT 116 C766(1.45); C767(1.11); C1229(1.03); C1000(1.04)  LDD0806  [14]
 LDCM0490  CL95 HCT 116 C766(8.98); C767(5.07); C1229(1.07); C1000(1.18)  LDD0807  [14]
 LDCM0491  CL96 HCT 116 C766(1.63); C767(1.42); C1229(1.02); C1000(1.29)  LDD0808  [14]
 LDCM0492  CL97 HCT 116 C766(2.71); C767(1.99); C1229(0.95); C1000(1.49)  LDD0809  [14]
 LDCM0493  CL98 HCT 116 C766(1.93); C767(1.98); C1229(0.99); C1000(1.18)  LDD0810  [14]
 LDCM0494  CL99 HCT 116 C766(1.25); C767(1.24); C1229(1.05); C1000(1.18)  LDD0811  [14]
 LDCM0191  Compound 21 HEK-293T 4.70  LDD0508  [31]
 LDCM0190  Compound 34 HEK-293T 4.60  LDD0510  [31]
 LDCM0193  Compound 36 HEK-293T 4.04  LDD0511  [31]
 LDCM0634  CY-0357 Hep-G2 C439(2.91); C596(0.87); C286(0.60)  LDD2228  [21]
 LDCM0495  E2913 HEK-293T C286(0.95); C596(1.08); C121(0.90); C1000(1.01)  LDD1698  [36]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C421(42.68); C596(1.78); C1229(1.31)  LDD1702  [8]
 LDCM0202  EV-93 T cell C767(4.41)  LDD0514  [37]
 LDCM0204  EV-97 T cell C767(4.83)  LDD0524  [37]
 LDCM0625  F8 Ramos C121(0.83); C1229(0.60); C596(1.36); C286(1.67)  LDD2187  [38]
 LDCM0572  Fragment10 Ramos C767(6.39)  LDD1390  [39]
 LDCM0573  Fragment11 MDA-MB-231 C439(0.88)  LDD1467  [39]
 LDCM0574  Fragment12 MDA-MB-231 C439(6.71)  LDD1468  [39]
 LDCM0575  Fragment13 Ramos C767(1.44)  LDD1396  [39]
 LDCM0576  Fragment14 MDA-MB-231 C767(3.64)  LDD1397  [39]
 LDCM0577  Fragment15 Ramos C767(9.89)  LDD1400  [39]
 LDCM0579  Fragment20 Ramos C121(3.96); C1229(1.46); C596(1.64); C816(4.61)  LDD2194  [38]
 LDCM0580  Fragment21 MDA-MB-231 C439(0.67)  LDD1473  [39]
 LDCM0582  Fragment23 Ramos C767(1.52)  LDD1409  [39]
 LDCM0584  Fragment25 MDA-MB-231 C767(0.97)  LDD1411  [39]
 LDCM0578  Fragment27 MDA-MB-231 C767(0.83)  LDD1401  [39]
 LDCM0586  Fragment28 MDA-MB-231 C439(0.87)  LDD1475  [39]
 LDCM0587  Fragment29 MDA-MB-231 C767(1.02)  LDD1417  [39]
 LDCM0588  Fragment30 Ramos C121(2.17); C1229(0.90); C596(1.35); C286(2.05)  LDD2199  [38]
 LDCM0589  Fragment31 MDA-MB-231 C439(20.00)  LDD1477  [39]
 LDCM0590  Fragment32 Ramos C121(1.16); C1229(0.64); C596(2.03); C816(0.42)  LDD2201  [38]
 LDCM0468  Fragment33 HCT 116 C766(1.13); C767(1.63); C1229(1.00); C1000(1.07)  LDD0785  [14]
 LDCM0593  Fragment35 Ramos C767(1.41)  LDD1430  [39]
 LDCM0595  Fragment37 Ramos C767(0.95)  LDD1432  [39]
 LDCM0596  Fragment38 MDA-MB-231 C767(1.21)  LDD1433  [39]
 LDCM0566  Fragment4 MDA-MB-231 C767(20.00)  LDD1378  [39]
 LDCM0598  Fragment40 Ramos C767(1.43)  LDD1437  [39]
 LDCM0599  Fragment41 MDA-MB-231 C767(1.19)  LDD1438  [39]
 LDCM0600  Fragment42 Ramos C767(0.93)  LDD1440  [39]
 LDCM0427  Fragment51 HCT 116 C766(0.78); C767(1.12); C1229(0.79); C1000(1.01)  LDD0744  [14]
 LDCM0610  Fragment52 MDA-MB-231 C767(1.07)  LDD1452  [39]
 LDCM0614  Fragment56 MDA-MB-231 C439(1.24)  LDD1484  [39]
 LDCM0569  Fragment7 Ramos C767(20.00)  LDD1384  [39]
 LDCM0570  Fragment8 MDA-MB-231 C767(15.32)  LDD1385  [39]
 LDCM0571  Fragment9 Ramos C767(2.06)  LDD1388  [39]
 LDCM0116  HHS-0101 DM93 Y1325(1.25)  LDD0264  [12]
 LDCM0117  HHS-0201 DM93 Y1325(1.82)  LDD0265  [12]
 LDCM0118  HHS-0301 DM93 Y1325(2.56)  LDD0266  [12]
 LDCM0119  HHS-0401 DM93 Y1325(2.48)  LDD0267  [12]
 LDCM0120  HHS-0701 DM93 Y1325(2.19)  LDD0268  [12]
 LDCM0107  IAA HeLa C1229(0.00); H859(0.00); H92(0.00)  LDD0221  [28]
 LDCM0022  KB02 HCT 116 C439(3.02); C596(2.56); C772(1.03)  LDD0080  [14]
 LDCM0023  KB03 HCT 116 C439(1.82); C596(1.22); C772(1.66)  LDD0081  [14]
 LDCM0024  KB05 HCT 116 C439(14.92); C596(2.04); C772(1.02)  LDD0082  [14]
 LDCM0030  Luteolin HEK-293T 4.89  LDD0182  [10]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C286(1.18)  LDD2102  [8]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C421(0.65); C286(0.39); C596(0.52)  LDD2121  [8]
 LDCM0109  NEM HeLa H372(0.00); H843(0.00); H92(0.00); H859(0.00)  LDD0223  [28]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C421(0.76); C596(0.49)  LDD2089  [8]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C286(2.07); C596(1.05)  LDD2090  [8]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C286(0.96)  LDD2092  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C421(1.37); C767(1.11)  LDD2093  [8]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C286(1.47)  LDD2094  [8]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C286(0.27); C767(1.24)  LDD2096  [8]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C421(0.99)  LDD2097  [8]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C286(1.89)  LDD2098  [8]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C286(0.56); C596(0.78); C816(1.11)  LDD2099  [8]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C286(1.16)  LDD2100  [8]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C767(0.96)  LDD2101  [8]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C286(1.01)  LDD2104  [8]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C286(2.55); C816(1.74)  LDD2105  [8]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C421(1.04); C286(0.94); C596(0.99); C816(0.72)  LDD2107  [8]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C596(0.80); C816(0.64)  LDD2109  [8]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C286(3.46)  LDD2110  [8]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C596(0.81)  LDD2111  [8]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C286(0.66)  LDD2114  [8]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C286(0.63)  LDD2115  [8]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C286(0.75)  LDD2116  [8]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C421(0.73); C286(0.63); C596(1.01)  LDD2118  [8]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C816(1.07)  LDD2119  [8]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C286(0.88); C596(1.08); C816(0.58)  LDD2120  [8]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C421(0.42); C286(0.59); C596(0.45); C816(0.16)  LDD2122  [8]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C286(0.61); C596(0.84); C816(0.54)  LDD2123  [8]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C421(0.35); C286(0.63); C816(0.24)  LDD2124  [8]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C286(0.59); C596(0.72); C766(0.68); C816(0.70)  LDD2125  [8]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C286(0.68)  LDD2126  [8]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C421(1.23); C286(1.03); C596(0.91); C766(0.84)  LDD2127  [8]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C286(0.72); C816(0.58)  LDD2128  [8]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C421(1.07)  LDD2129  [8]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C286(0.80); C766(0.83)  LDD2133  [8]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C286(1.09); C767(0.66); C766(0.51)  LDD2134  [8]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C286(0.53); C767(1.12); C766(0.76)  LDD2135  [8]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C421(1.41); C286(1.40); C596(1.14)  LDD2136  [8]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C286(0.79); C596(0.98); C767(0.60); C816(0.63)  LDD2137  [8]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C286(1.40); C596(0.70); C767(0.49)  LDD1700  [8]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C421(1.35); C596(0.65); C766(1.27); C816(0.49)  LDD2140  [8]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C286(0.77)  LDD2141  [8]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C421(0.96); C286(1.16)  LDD2143  [8]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C421(2.10); C286(4.15); C766(2.01)  LDD2144  [8]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C421(1.04); C286(0.49)  LDD2146  [8]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C286(4.25); C766(1.64)  LDD2147  [8]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C767(1.07)  LDD2148  [8]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C421(0.67); C286(0.61); C816(1.05)  LDD2149  [8]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C421(0.49); C286(0.53); C596(0.42)  LDD2150  [8]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C286(0.84)  LDD2151  [8]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C286(4.48); C596(1.42)  LDD2153  [8]
 LDCM0627  NUDT7-COV-1 HEK-293T C439(1.09); C421(0.70)  LDD2206  [40]
 LDCM0628  OTUB2-COV-1 HEK-293T C1229(0.86); C596(0.85); C421(0.76); C767(0.53)  LDD2207  [40]
 LDCM0003  Sulforaphane MCF-7 3.60  LDD0042  [9]
 LDCM0021  THZ1 HCT 116 C767(1.06); C439(1.14); C766(0.96); C596(1.02)  LDD2173  [14]
 LDCM0112  W16 Hep-G2 C767(2.25)  LDD0239  [29]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Condensin complex subunit 2 (NCAPH) CND2 (condensin subunit 2) family Q15003
Condensin complex subunit 3 (NCAPG) CND3 (condensin subunit 3) family Q9BPX3

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
4 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
5 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Competition-based, quantitative chemical proteomics in breast cancer cells identifies new target profiles for sulforaphane. Chem Commun (Camb). 2017 May 4;53(37):5182-5185. doi: 10.1039/c6cc08797c.
Mass spectrometry data entry: PXD006279
10 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
11 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
12 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
13 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
14 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
15 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
16 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
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Mass spectrometry data entry: PXD028853
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Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
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Mass spectrometry data entry: PXD029500 , PXD031647
20 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
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Mass spectrometry data entry: PXD041264
22 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
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Mass spectrometry data entry: PXD022279
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Mass spectrometry data entry: PXD036569
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Mass spectrometry data entry: PXD039931
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Mass spectrometry data entry: PXD044402
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Mass spectrometry data entry: PXD027578
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