Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment9  Competitor Info 
Competitor Concentration 500 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Lymph node
Disease Model Burkitt lymphoma [ICD-11:2A85]
Model Name Human burkitt lymphoma cell lysate (Ramos)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 90 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 20.0
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 20.0
 LDTP07651  Monofunctional C1-tetrahydrofolate synthase, mitochondrial (MTHFD1L) C906 20.0
 LDTP12190  NmrA-like family domain-containing protein 1 (NMRAL1) C154 20.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 20.0
 LDTP11030  Serine/threonine-protein kinase VRK1 (VRK1) C50 20.0
 LDTP09412  Serine/threonine-protein kinase Nek9 (NEK9) C623 15.4
 LDTP00701  D-3-phosphoglycerate dehydrogenase (PHGDH) C369 14.0
 LDTP10386  ERO1-like protein alpha (ERO1A) C166 9.7
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 9.6
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 5.8
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 4.7
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C863 4.1
 LDTP10418  Mannose-1-phosphate guanyltransferase alpha (GMPPA) C389 3.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 3.1
 LDTP06603  Cyclin-dependent kinase inhibitor 3 (CDKN3) C39 2.7
 LDTP04601  Arginine--tRNA ligase, cytoplasmic (RARS1) C34 2.5
 LDTP00246  Eukaryotic translation initiation factor 3 subunit F (EIF3F) C256 2.2
 LDTP02522  60 kDa heat shock protein, mitochondrial (HSPD1) C442 2.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 2.1
 LDTP10954  3-hydroxyacyl-CoA dehydrogenase type-2 (HSD17B10) C214 2.0
 LDTP03512  Peroxiredoxin-5, mitochondrial (PRDX5) C204 1.9
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 1.9
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.8
 LDTP02672  Elongation factor 2 (EEF2) C41 1.8
 LDTP00089  Glycerol-3-phosphate phosphatase (PGP) C297 1.8
 LDTP17082  Isoamyl acetate-hydrolyzing esterase 1 homolog (IAH1) C137 1.7
 LDTP09338  NEDD8-activating enzyme E1 catalytic subunit (UBA3) C237 1.6
 LDTP03299  Cyclin-dependent kinase 2 (CDK2) C177 1.6
 LDTP03159  Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (PAICS) C374 1.6
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 1.6
 LDTP00273  Dynamin-1-like protein (DNM1L) C367 1.5
 LDTP10997  Protein arginine N-methyltransferase 1 (PRMT1) C109 1.5
 LDTP06199  Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform (PPP2R5D) C17 1.5
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 1.5
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C620 1.5
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.5
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.5
 LDTP03400  Deoxycytidine kinase (DCK) C45 1.4
 LDTP02333  Glutathione S-transferase P (GSTP1) C48 1.4
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.4
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.4
 LDTP14036  Helicase ARIP4 (RAD54L2) C820 1.4
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 1.4
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.4
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C295 1.3
 LDTP08135  E3 ubiquitin-protein ligase HUWE1 (HUWE1) C4367 1.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.2
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C217 1.2
 LDTP02580  C-1-tetrahydrofolate synthase, cytoplasmic (MTHFD1) C918 1.2
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.2
 LDTP04424  Galactokinase (GALK1) C182 1.2
 LDTP03806  ADP-ribosylation factor-like protein 3 (ARL3) C174 1.2
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.2
 LDTP02188  Protein disulfide-isomerase (P4HB) C397 1.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.1
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C129 1.1
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C301 1.1
 LDTP02693  Acylamino-acid-releasing enzyme (APEH) C641 1.1
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.1
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.1
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C721 1.0
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.0
 LDTP01470  Lysine-specific demethylase 4B (KDM4B) C694 1.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 1.0
 LDTP11388  N-alpha-acetyltransferase 15, NatA auxiliary subunit (NAA15) C322 1.0
 LDTP02733  Pyruvate kinase PKM (PKM) C423 1.0
 LDTP04306  Adenosine 5'-monophosphoramidase HINT1 (HINT1) C84 1.0
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C376 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C315 1.0
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 1.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 1.0
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C347 1.0
 LDTP06621  Ubiquitin-conjugating enzyme E2 S (UBE2S) C118 1.0
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 0.9
 LDTP04374  Dynamin-2 (DNM2) C27 0.9
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 0.9
 LDTP06338  Prostaglandin E synthase 3 (PTGES3) C58 0.9
 LDTP07907  Tubulin alpha-1A chain (TUBA1A) C347 0.9
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 0.9
 LDTP04689  Adenosine kinase (ADK) C353 0.8
 LDTP05314  ATP-dependent 6-phosphofructokinase, platelet type (PFKP) C641 0.8
 LDTP04265  Serine--tRNA ligase, cytoplasmic (SARS1) C438 0.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.8
 LDTP02672  Elongation factor 2 (EEF2) C136 0.7
 LDTP04061  26S proteasome regulatory subunit 6B (PSMC4) C210 0.6
 LDTP04077  Dual specificity mitogen-activated protein kinase kinase 4 (MAP2K4) C246 0.5
Transporter and channel
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04707  Protein SEC13 homolog (SEC13) C187 2.1
 LDTP13661  Sorting nexin-6 (SNX6) C264 1.7
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 1.5
 LDTP04259  Signal recognition particle 9 kDa protein (SRP9) C48 1.4
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 1.4
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.3
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 1.3
 LDTP00501  Exportin-1 (XPO1) C34 1.1
 LDTP01574  Importin-7 (IPO7) C757 1.1
 LDTP13490  Apoptotic chromatin condensation inducer in the nucleus (ACIN1) C1223 1.0
 LDTP05057  Small ribosomal subunit protein RACK1 (RACK1) C182 0.8
 LDTP00501  Exportin-1 (XPO1) C528 0.7
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.6
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.6
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.1
 LDTP07940  eIF5-mimic protein 2 (BZW1) C35 1.1
Other
Click to Show/Hide to Show 83 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12737  BRISC and BRCA1-A complex member 1 (BABAM1) C222 20.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 20.0
 LDTP14337  Protein strawberry notch homolog 1 (SBNO1) C445 20.0
 LDTP04092  Crk-like protein (CRKL) C249 5.0
 LDTP15730  Ataxin-7-like protein 3B (ATXN7L3B) C75 4.5
 LDTP10990  T-complex protein 1 subunit eta (CCT7) C29 3.3
 LDTP11197  Mini-chromosome maintenance complex-binding protein (MCMBP) C325 2.9
 LDTP12914  Hsp70-binding protein 1 (HSPBP1) C204 2.9
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 2.8
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 2.4
 LDTP00552  Actin-related protein 2/3 complex subunit 3 (ARPC3) C162 2.1
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C767 2.1
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C28 2.0
 LDTP00431  Kinetochore protein NDC80 homolog (NDC80) C449 1.9
 LDTP12754  H/ACA ribonucleoprotein complex subunit 2 (NHP2) C18 1.8
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 1.7
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.7
 LDTP01567  Structural maintenance of chromosomes protein 2 (SMC2) C1174 1.7
 LDTP05867  Treacle protein (TCOF1) C38 1.6
 LDTP04110  Small ribosomal subunit protein uS7 (RPS5) C66 1.6
 LDTP01532  ZW10 interactor (ZWINT) C54 1.6
 LDTP05930  SNW domain-containing protein 1 (SNW1) C250 1.6
 LDTP03665  Cleavage stimulation factor subunit 2 (CSTF2) C150 1.5
 LDTP12780  THUMP domain-containing protein 1 (THUMPD1) C31 1.5
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.5
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.5
 LDTP05484  Proteasome activator complex subunit 1 (PSME1) C22 1.4
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 1.4
 LDTP04902  Actin-related protein 3 (ACTR3) C235 1.4
 LDTP07755  Dynamin-binding protein (DNMBP) C691 1.4
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 1.4
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.3
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.3
 LDTP13817  Nuclear migration protein nudC (NUDC) C188 1.3
 LDTP10700  KH domain-containing RNA-binding protein QKI (QKI) C35 1.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.3
 LDTP10864  Calponin-2 (CNN2) C164 1.3
 LDTP00756  Heterogeneous nuclear ribonucleoprotein R (HNRNPR) C99 1.2
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.2
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 1.2
 LDTP04975  Small ribosomal subunit protein uS17 (RPS11) C60 1.2
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.2
 LDTP04390  T-complex protein 1 subunit theta (CCT8) C244 1.2
 LDTP11239  Protein misato homolog 1 (MSTO1) C485 1.2
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) C615 1.1
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.1
 LDTP02934  T-complex protein 1 subunit alpha (TCP1) C76 1.1
 LDTP07947  Eukaryotic translation initiation factor 3 subunit M (EIF3M) C134 1.1
 LDTP00202  AH receptor-interacting protein (AIP) C122 1.1
 LDTP03695  Heat shock 70 kDa protein 4 (HSPA4) C34 1.1
 LDTP12685  Integrator complex subunit 13 (INTS13) C349 1.1
 LDTP15677  Ribosomal protein eL42-like (RPL36AL) C88 1.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 1.0
 LDTP03987  Small ribosomal subunit protein eS27 (RPS27) C77 1.0
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.0
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C122 1.0
 LDTP06268  Condensin complex subunit 2 (NCAPH) C418 1.0
 LDTP11239  Protein misato homolog 1 (MSTO1) C403 1.0
 LDTP02205  Tubulin beta chain (TUBB) C239 1.0
 LDTP04518  DNA mismatch repair protein Msh6 (MSH6) C1117 0.9
 LDTP06082  Dynactin subunit 1 (DCTN1) C1252 0.9
 LDTP03395  Large ribosomal subunit protein uL16 (RPL10) C105 0.9
 LDTP03815  Large ribosomal subunit protein uL4 (RPL4) C96 0.9
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C660 0.9
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.9
 LDTP09580  Programmed cell death 6-interacting protein (PDCD6IP) C250 0.9
 LDTP02205  Tubulin beta chain (TUBB) C354 0.9
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 0.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 0.9
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 0.9
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C109 0.9
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 0.8
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 0.8
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C36 0.8
 LDTP06083  Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1) C1999 0.8
 LDTP03865  Large ribosomal subunit protein uL3 (RPL3) C253 0.8
 LDTP00430  Transcription elongation regulator 1 (TCERG1) C1062 0.7
 LDTP04487  Cyclin-H (CCNH) C244 0.7
 LDTP03244  Cofilin-1 (CFL1) C80 0.7
 LDTP04971  Small ribosomal subunit protein uS12 (RPS23) C90 0.7
 LDTP11890  Protein unc-45 homolog A (UNC45A) C426 0.7
 LDTP04028  DNA mismatch repair protein Msh2 (MSH2) C843 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.