Details of the Target

General Information of Target

Target ID LDTP13964
Target Name MOB-like protein phocein (MOB4)
Gene Name MOB4
Gene ID 25843
Synonyms
MOB3; MOBKL3; PHOCN; PREI3; MOB-like protein phocein; 2C4D; Class II mMOB1; Mob1 homolog 3; Mob3; Mps one binder kinase activator-like 3; Preimplantation protein 3
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MAAAFRKAAKSRQREHRERSQPGFRKHLGLLEKKKDYKLRADDYRKKQEYLKALRKKALE
KNPDEFYYKMTRVKLQDGVHIIKETKEEVTPEQLKLMRTQDVKYIEMKRVAEAKKIERLK
SELHLLDFQGKQQNKHVFFFDTKKEVEQFDVATHLQTAPELVDRVFNRPRIETLQKEKVK
GVTNQTGLKRIAKERQKQYNCLTQRIEREKKLFVIAQKIQTRKDLMDKTQKVKVKKETVN
SPAIYKFQSRRKR
Target Bioclass
Other
Family
MOB1/phocein family
Subcellular location
Cytoplasm, perinuclear region
Function May play a role in membrane trafficking, specifically in membrane budding reactions.
Uniprot ID
Q9Y3A3
Ensemble ID
ENST00000233892.8
HGNC ID
HGNC:17261

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A154V DBIA    Probe Info 
CHL1 SNV: p.K18E DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 28 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
STPyne
 Probe Info  		K140(6.27); K155(10.00); K193(10.00)  LDD0277  [2]
Probe 1
 Probe Info  		Y124(9.87)  LDD3495  [3]
BTD
 Probe Info  		C160(2.02)  LDD1700  [4]
AHL-Pu-1
 Probe Info  		C119(2.48)  LDD0171  [5]
DBIA
 Probe Info  		C119(1.06); C134(0.83); C51(1.13)  LDD0531  [6]
ATP probe
 Probe Info  		K155(0.00); K140(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C51(0.00); C119(0.00); C134(0.00); C188(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C188(0.00); C51(0.00); C119(0.00)  LDD0032  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C119(0.00); C134(0.00); C78(0.00); C188(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		C119(0.00); C134(0.00)  LDD0026  [11]
NAIA_4
 Probe Info  		C119(0.00); C134(0.00)  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		N.A.  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		N.A.  LDD0005  [13]
PF-06672131
 Probe Info  		N.A.  LDD0017  [15]
VSF
 Probe Info  		N.A.  LDD0007  [13]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
Acrolein
 Probe Info  		C134(0.00); C51(0.00)  LDD0217  [17]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [17]
Methacrolein
 Probe Info  		C51(0.00); C134(0.00)  LDD0218  [17]
W1
 Probe Info  		N.A.  LDD0236  [18]
AOyne
 Probe Info  		14.00  LDD0443  [19]
NAIA_5
 Probe Info  		C51(0.00); C134(0.00); C78(0.00); C188(0.00)  LDD2223  [12]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		10.48  LDD1728  [20]
C106
 Probe Info  		17.51  LDD1793  [20]
C284
 Probe Info  		32.67  LDD1954  [20]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C134(0.45)  LDD2117  [4]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C160(1.06); C134(0.80)  LDD2152  [4]
 LDCM0026  4SU-RNA+native RNA DM93 C119(2.48)  LDD0171  [5]
 LDCM0214  AC1 HCT 116 C119(1.06); C134(0.83); C51(1.13)  LDD0531  [6]
 LDCM0215  AC10 HCT 116 C119(1.33); C134(1.08); C51(0.66)  LDD0532  [6]
 LDCM0216  AC100 HCT 116 C119(0.86); C134(0.97); C51(0.93)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C119(0.70); C134(0.86); C51(0.93)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C119(0.99); C134(0.92); C51(0.74)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C119(0.85); C134(1.08); C51(0.57)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C119(0.86); C134(0.96); C51(0.60)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C119(0.80); C134(1.05); C51(0.91)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C119(1.21); C134(0.99); C51(0.79)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C119(0.91); C134(1.09); C51(0.59)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C119(1.00); C134(0.99); C51(0.94)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C119(1.12); C134(0.93); C51(1.02)  LDD0542  [6]
 LDCM0226  AC11 HCT 116 C119(1.37); C134(1.20); C51(0.63)  LDD0543  [6]
 LDCM0227  AC110 HCT 116 C119(0.75); C134(0.89); C51(0.90)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C119(0.90); C134(0.98); C51(0.84)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C119(0.85); C134(1.13); C51(0.64)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C119(1.28); C134(1.00)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C119(1.17); C134(1.07)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C119(1.46); C134(1.07)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C119(1.03); C134(1.04)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C119(1.22); C134(1.10)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C119(1.32); C134(0.99)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C119(1.39); C134(1.10)  LDD0553  [6]
 LDCM0237  AC12 HCT 116 C119(1.08); C134(1.04); C51(1.18)  LDD0554  [6]
 LDCM0238  AC120 HCT 116 C119(0.91); C134(1.09)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C119(1.19); C134(1.25)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C119(1.26); C134(1.11)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C119(1.01); C134(1.19)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C119(1.14); C134(1.13)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C119(1.14); C134(1.10)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C119(0.94); C134(1.07)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C119(1.09); C134(1.16)  LDD0562  [6]
 LDCM0246  AC128 HCT 116 C134(1.09)  LDD0563  [6]
 LDCM0247  AC129 HCT 116 C134(1.11)  LDD0564  [6]
 LDCM0249  AC130 HCT 116 C134(1.22)  LDD0566  [6]
 LDCM0250  AC131 HCT 116 C134(1.39)  LDD0567  [6]
 LDCM0251  AC132 HCT 116 C134(1.44)  LDD0568  [6]
 LDCM0252  AC133 HCT 116 C134(1.21)  LDD0569  [6]
 LDCM0253  AC134 HCT 116 C134(1.31)  LDD0570  [6]
 LDCM0254  AC135 HCT 116 C134(1.20)  LDD0571  [6]
 LDCM0255  AC136 HCT 116 C134(1.48)  LDD0572  [6]
 LDCM0256  AC137 HCT 116 C134(1.40)  LDD0573  [6]
 LDCM0257  AC138 HCT 116 C134(2.09)  LDD0574  [6]
 LDCM0258  AC139 HCT 116 C134(1.73)  LDD0575  [6]
 LDCM0259  AC14 HCT 116 C119(1.12); C134(0.95); C51(0.80)  LDD0576  [6]
 LDCM0260  AC140 HCT 116 C134(1.68)  LDD0577  [6]
 LDCM0261  AC141 HCT 116 C134(1.77)  LDD0578  [6]
 LDCM0262  AC142 HCT 116 C134(1.35)  LDD0579  [6]
 LDCM0263  AC143 HCT 116 C119(1.08); C134(1.10)  LDD0580  [6]
 LDCM0264  AC144 HCT 116 C119(0.91); C134(1.24)  LDD0581  [6]
 LDCM0265  AC145 HCT 116 C119(0.91); C134(1.15)  LDD0582  [6]
 LDCM0266  AC146 HCT 116 C119(1.05); C134(1.27)  LDD0583  [6]
 LDCM0267  AC147 HCT 116 C119(0.78); C134(1.36)  LDD0584  [6]
 LDCM0268  AC148 HCT 116 C119(1.36); C134(1.56)  LDD0585  [6]
 LDCM0269  AC149 HCT 116 C119(1.19); C134(1.38)  LDD0586  [6]
 LDCM0270  AC15 HCT 116 C51(0.83); C134(0.97); C119(1.20)  LDD0587  [6]
 LDCM0271  AC150 HCT 116 C119(1.06); C134(1.10)  LDD0588  [6]
 LDCM0272  AC151 HCT 116 C119(0.95); C134(1.09)  LDD0589  [6]
 LDCM0273  AC152 HCT 116 C119(1.15); C134(1.34)  LDD0590  [6]
 LDCM0274  AC153 HCT 116 C119(1.23); C134(1.77)  LDD0591  [6]
 LDCM0621  AC154 HCT 116 C119(0.91); C134(1.27)  LDD2158  [6]
 LDCM0622  AC155 HCT 116 C119(0.93); C134(1.18)  LDD2159  [6]
 LDCM0623  AC156 HCT 116 C119(1.00); C134(1.18)  LDD2160  [6]
 LDCM0624  AC157 HCT 116 C119(0.86); C134(0.98)  LDD2161  [6]
 LDCM0276  AC17 HCT 116 C51(0.92); C119(0.98); C134(1.09)  LDD0593  [6]
 LDCM0277  AC18 HCT 116 C119(0.74); C134(0.87); C51(1.12)  LDD0594  [6]
 LDCM0278  AC19 HCT 116 C51(0.71); C119(0.72); C134(0.99)  LDD0595  [6]
 LDCM0279  AC2 HCT 116 C134(0.98); C119(1.02); C51(1.29)  LDD0596  [6]
 LDCM0280  AC20 HCT 116 C119(0.57); C51(0.63); C134(0.94)  LDD0597  [6]
 LDCM0281  AC21 HCT 116 C51(0.61); C119(0.78); C134(0.83)  LDD0598  [6]
 LDCM0282  AC22 HCT 116 C51(0.69); C119(0.82); C134(0.86)  LDD0599  [6]
 LDCM0283  AC23 HCT 116 C51(0.59); C119(0.78); C134(0.80)  LDD0600  [6]
 LDCM0284  AC24 HCT 116 C51(0.76); C119(0.81); C134(0.99)  LDD0601  [6]
 LDCM0285  AC25 HCT 116 C134(0.65); C119(0.86)  LDD0602  [6]
 LDCM0286  AC26 HCT 116 C134(0.78); C119(0.89)  LDD0603  [6]
 LDCM0287  AC27 HCT 116 C134(0.92); C119(0.95)  LDD0604  [6]
 LDCM0288  AC28 HCT 116 C119(0.80); C134(0.92)  LDD0605  [6]
 LDCM0289  AC29 HCT 116 C119(0.80); C134(0.85)  LDD0606  [6]
 LDCM0290  AC3 HCT 116 C134(0.88); C119(1.07); C51(1.13)  LDD0607  [6]
 LDCM0291  AC30 HCT 116 C119(0.83); C134(0.93)  LDD0608  [6]
 LDCM0292  AC31 HCT 116 C134(0.82); C119(0.94)  LDD0609  [6]
 LDCM0293  AC32 HCT 116 C119(0.79); C134(0.91)  LDD0610  [6]
 LDCM0294  AC33 HCT 116 C134(0.87); C119(1.08)  LDD0611  [6]
 LDCM0295  AC34 HCT 116 C134(0.89); C119(0.90)  LDD0612  [6]
 LDCM0296  AC35 HCT 116 C119(0.88); C134(0.94); C188(1.07); C51(1.54)  LDD0613  [6]
 LDCM0297  AC36 HCT 116 C188(0.85); C134(0.91); C51(1.29); C119(1.32)  LDD0614  [6]
 LDCM0298  AC37 HCT 116 C188(0.75); C51(0.82); C134(0.93); C119(1.18)  LDD0615  [6]
 LDCM0299  AC38 HCT 116 C51(0.82); C119(0.91); C134(0.92); C188(0.94)  LDD0616  [6]
 LDCM0300  AC39 HCT 116 C188(0.88); C134(1.02); C51(1.04); C119(1.05)  LDD0617  [6]
 LDCM0301  AC4 HCT 116 C134(0.92); C119(1.11); C51(1.36)  LDD0618  [6]
 LDCM0302  AC40 HCT 116 C51(0.70); C188(0.89); C119(1.04); C134(1.11)  LDD0619  [6]
 LDCM0303  AC41 HCT 116 C188(0.88); C51(0.93); C134(0.99); C119(1.05)  LDD0620  [6]
 LDCM0304  AC42 HCT 116 C188(0.90); C51(0.90); C134(1.00); C119(1.12)  LDD0621  [6]
 LDCM0305  AC43 HCT 116 C51(0.71); C188(0.91); C134(0.94); C119(1.02)  LDD0622  [6]
 LDCM0306  AC44 HCT 116 C51(0.77); C188(0.87); C119(0.96); C134(0.97)  LDD0623  [6]
 LDCM0307  AC45 HCT 116 C188(0.82); C51(1.01); C119(1.04); C134(1.07)  LDD0624  [6]
 LDCM0308  AC46 HCT 116 C188(0.89); C51(0.96); C119(1.02); C134(1.18)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C51(0.91); C119(1.01); C188(1.01); C134(1.16)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C188(0.91); C51(0.96); C119(1.08); C134(1.21)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C51(0.58); C119(0.90); C188(0.93); C134(1.48)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C134(0.85); C119(1.19); C51(1.26)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C51(0.67); C188(0.81); C119(0.96); C134(1.44)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C119(0.88); C134(1.07); C51(1.21); C188(1.46)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C51(0.81); C119(0.96); C188(1.12); C134(1.18)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C51(0.85); C188(0.92); C134(1.09); C119(1.23)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C51(0.93); C188(0.94); C119(1.21); C134(1.21)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C51(0.65); C188(0.75); C119(0.94); C134(1.26)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C51(0.57); C188(0.59); C119(0.80); C134(1.45)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C119(1.00); C134(1.07)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C119(0.83); C134(1.23)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C119(0.89); C134(1.11)  LDD0639  [6]
 LDCM0323  AC6 HCT 116 C51(0.76); C134(1.19); C119(1.20)  LDD0640  [6]
 LDCM0324  AC60 HCT 116 C119(1.02); C134(1.02)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C119(1.00); C134(1.00)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C134(0.95); C119(1.00)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C134(0.89); C119(1.01)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C119(0.87); C134(0.92)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C119(1.07); C134(1.20)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C119(0.95); C134(1.11)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C119(0.89); C134(1.12)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C119(0.81); C134(1.09)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C119(0.64); C134(1.18)  LDD0650  [6]
 LDCM0334  AC7 HCT 116 C51(0.77); C134(1.06); C119(1.43)  LDD0651  [6]
 LDCM0335  AC70 HCT 116 C119(0.74); C134(1.16)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C119(0.75); C134(0.99)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C119(0.88); C134(1.09)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C119(0.78); C134(1.44)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C119(0.95); C134(1.39)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C119(0.70); C134(1.35)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C119(0.82); C134(1.20)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C119(0.67); C134(1.21)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C119(0.72); C134(1.10)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C119(0.67); C134(1.10)  LDD0661  [6]
 LDCM0345  AC8 HCT 116 C51(0.82); C134(1.10); C119(1.44)  LDD0662  [6]
 LDCM0346  AC80 HCT 116 C119(0.81); C134(1.17)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C119(0.80); C134(1.79)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C119(0.76); C134(1.91)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C119(0.72); C188(0.98); C134(1.24)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C188(0.71); C134(1.30); C119(1.33)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C188(0.72); C119(1.04); C134(1.23)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C188(0.82); C134(1.07); C119(1.32)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C134(1.01); C188(1.09); C119(1.62)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C119(0.78); C188(1.09); C134(1.16)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C188(0.76); C119(0.93); C134(1.08)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C188(0.78); C134(0.99); C119(0.99)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C188(0.81); C119(0.85); C134(1.25)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C188(0.76); C119(0.91); C134(1.33)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C188(0.86); C134(1.07); C119(1.35)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C134(0.89); C119(0.96); C188(1.07)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C188(0.86); C134(1.04); C119(1.33)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C119(0.85); C188(0.96); C134(1.00)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C188(0.82); C119(0.96); C134(1.77)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C51(0.27); C119(0.55); C134(1.10)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C119(0.66); C134(0.93); C51(1.00)  LDD0683  [6]
 LDCM0520  AKOS000195272 MDA-MB-231 C160(0.69)  LDD2113  [4]
 LDCM0248  AKOS034007472 HCT 116 C119(1.33); C134(1.03); C51(1.07)  LDD0565  [6]
 LDCM0356  AKOS034007680 HCT 116 C51(0.87); C134(1.31); C119(1.42)  LDD0673  [6]
 LDCM0275  AKOS034007705 HCT 116 C51(0.63); C134(0.99); C119(1.24)  LDD0592  [6]
 LDCM0156  Aniline NCI-H1299 13.68  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C134(1.06); C119(1.04)  LDD2171  [6]
 LDCM0632  CL-Sc Hep-G2 C134(0.81); C134(0.70)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C51(0.85); C134(0.95); C119(1.10)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C51(0.45); C134(1.17); C119(1.28)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C134(0.87); C119(1.07); C51(1.31)  LDD0686  [6]
 LDCM0370  CL101 HCT 116 C51(0.83); C134(0.97); C119(1.08)  LDD0687  [6]
 LDCM0371  CL102 HCT 116 C134(0.97); C51(1.23); C119(1.37)  LDD0688  [6]
 LDCM0372  CL103 HCT 116 C134(0.96); C119(1.15); C51(1.44)  LDD0689  [6]
 LDCM0373  CL104 HCT 116 C51(0.80); C134(1.02); C119(1.15)  LDD0690  [6]
 LDCM0374  CL105 HCT 116 C51(0.59); C119(0.83); C134(0.91)  LDD0691  [6]
 LDCM0375  CL106 HCT 116 C51(0.57); C134(0.74); C119(0.92)  LDD0692  [6]
 LDCM0376  CL107 HCT 116 C51(0.60); C134(0.81); C119(1.03)  LDD0693  [6]
 LDCM0377  CL108 HCT 116 C51(0.65); C134(0.83); C119(1.16)  LDD0694  [6]
 LDCM0378  CL109 HCT 116 C51(0.76); C134(0.87); C119(0.91)  LDD0695  [6]
 LDCM0379  CL11 HCT 116 C51(0.68); C119(1.12); C134(1.24)  LDD0696  [6]
 LDCM0380  CL110 HCT 116 C51(0.67); C119(0.71); C134(0.91)  LDD0697  [6]
 LDCM0381  CL111 HCT 116 C51(0.54); C119(0.82); C134(1.24)  LDD0698  [6]
 LDCM0382  CL112 HCT 116 C134(0.79); C119(1.01)  LDD0699  [6]
 LDCM0383  CL113 HCT 116 C119(0.75); C134(0.84)  LDD0700  [6]
 LDCM0384  CL114 HCT 116 C119(0.75); C134(0.89)  LDD0701  [6]
 LDCM0385  CL115 HCT 116 C119(0.77); C134(0.85)  LDD0702  [6]
 LDCM0386  CL116 HCT 116 C134(0.87); C119(1.09)  LDD0703  [6]
 LDCM0387  CL117 HCT 116 C51(0.67); C188(0.70); C119(1.10); C134(1.16)  LDD0704  [6]
 LDCM0388  CL118 HCT 116 C188(0.79); C134(1.00); C119(1.24); C51(1.26)  LDD0705  [6]
 LDCM0389  CL119 HCT 116 C51(0.64); C188(0.87); C119(0.99); C134(1.07)  LDD0706  [6]
 LDCM0390  CL12 HCT 116 C51(0.59); C134(1.21); C119(1.29)  LDD0707  [6]
 LDCM0391  CL120 HCT 116 C51(0.83); C188(0.87); C119(0.97); C134(1.01)  LDD0708  [6]
 LDCM0392  CL121 HCT 116 C134(0.79); C51(0.84); C119(0.88); C188(0.90)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C188(0.70); C51(0.75); C119(0.92); C134(1.29)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C188(0.78); C119(0.83); C51(0.83); C134(1.19)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C119(0.91); C188(0.97); C51(1.06); C134(1.33)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C119(1.20); C134(1.28)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C119(0.90); C134(1.02)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C119(0.87); C134(1.01)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C119(0.94); C134(1.15)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C51(0.59); C134(1.13); C119(1.24)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C51(0.40); C134(1.05); C119(1.28)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C51(0.52); C119(1.02); C134(1.10)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C119(0.93); C51(1.30)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C134(1.00); C51(1.01); C188(1.09); C119(1.18)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C134(1.04); C188(1.14); C51(1.50); C119(2.28)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C134(1.05); C119(1.15); C51(1.17); C188(1.21)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C51(0.91); C119(0.96); C134(1.07)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C134(0.99); C119(1.14); C188(1.25); C51(1.48)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C119(0.85); C134(0.91); C188(1.20); C51(1.21)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C188(0.78); C119(0.87); C134(0.90); C51(1.08)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C188(0.99); C134(1.13); C51(1.25); C119(1.33)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C119(0.86); C134(0.90); C188(0.94); C51(1.28)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C119(1.01); C134(1.02); C188(0.86); C51(1.24)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C119(1.06); C134(1.08); C188(1.17); C51(1.45)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C119(1.17); C134(0.94); C188(1.03); C51(1.34)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C119(1.01); C134(0.95); C188(1.19); C51(1.10)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C119(0.93); C134(0.99); C188(0.85); C51(1.30)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C119(0.93); C134(1.00); C51(0.85)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C119(1.14); C134(1.08); C188(1.00); C51(1.42)  LDD0736  [6]
 LDCM0420  CL31 HCT 116 C119(0.74); C134(0.97); C188(1.15); C51(0.59)  LDD0737  [6]
 LDCM0421  CL32 HCT 116 C119(0.71); C134(1.21); C51(0.83)  LDD0738  [6]
 LDCM0422  CL33 HCT 116 C119(0.90); C134(1.18); C51(0.66)  LDD0739  [6]
 LDCM0423  CL34 HCT 116 C119(0.83); C134(1.49); C51(0.67)  LDD0740  [6]
 LDCM0424  CL35 HCT 116 C119(0.96); C134(1.49); C51(0.73)  LDD0741  [6]
 LDCM0425  CL36 HCT 116 C119(0.78); C134(1.35); C51(0.98)  LDD0742  [6]
 LDCM0426  CL37 HCT 116 C119(0.73); C134(1.50); C51(0.65)  LDD0743  [6]
 LDCM0428  CL39 HCT 116 C119(0.72); C134(1.55); C51(0.75)  LDD0745  [6]
 LDCM0429  CL4 HCT 116 C119(1.16); C134(0.95); C51(0.75)  LDD0746  [6]
 LDCM0430  CL40 HCT 116 C119(0.67); C134(1.45); C51(0.78)  LDD0747  [6]
 LDCM0431  CL41 HCT 116 C119(0.70); C134(1.35); C51(0.87)  LDD0748  [6]
 LDCM0432  CL42 HCT 116 C119(0.64); C134(2.22); C51(0.47)  LDD0749  [6]
 LDCM0433  CL43 HCT 116 C119(0.82); C134(1.67); C51(0.67)  LDD0750  [6]
 LDCM0434  CL44 HCT 116 C119(0.73); C134(1.52); C51(0.71)  LDD0751  [6]
 LDCM0435  CL45 HCT 116 C119(0.69); C134(1.65); C51(0.57)  LDD0752  [6]
 LDCM0436  CL46 HCT 116 C119(1.24); C134(1.11); C51(1.02)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C119(1.06); C134(1.17); C51(0.85)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C119(1.23); C134(1.12); C51(1.00)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C119(1.19); C134(0.93); C51(1.02)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C119(1.08); C134(1.01); C51(0.60)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C119(1.05); C134(1.00); C51(0.88)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C119(1.26); C134(1.05); C51(0.94)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C119(0.99); C134(1.09); C51(0.93)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C119(1.00); C134(1.06); C51(0.87)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C119(1.07); C134(0.98); C51(0.93)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C119(1.23); C134(1.03); C51(0.97)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C119(1.04); C134(1.03); C51(0.81)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C119(0.94); C134(0.98); C51(0.95)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C119(1.30); C134(0.97); C51(1.07)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C119(1.25); C134(0.92); C51(1.05)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C119(0.97); C134(1.03); C51(0.69)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C119(1.19); C134(1.03); C51(0.92)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C119(0.95); C134(1.07)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C119(0.92); C134(1.03)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C119(1.01); C134(1.22)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C119(0.96); C134(1.12)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C119(1.11); C134(1.07)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C119(0.99); C134(1.20)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C119(0.95); C134(1.17)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C119(1.23); C134(1.13)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C119(0.98); C134(1.02)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C119(1.36); C134(1.15); C51(0.78)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C119(0.92); C134(1.18)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C119(0.84); C134(1.25)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C119(1.09); C134(1.06)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C119(0.75); C134(1.12)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C119(1.03); C134(1.15)  LDD0784  [6]
 LDCM0469  CL76 HCT 116 C119(0.85); C134(1.00); C51(1.15)  LDD0786  [6]
 LDCM0470  CL77 HCT 116 C119(1.19); C134(1.03); C51(1.21)  LDD0787  [6]
 LDCM0471  CL78 HCT 116 C119(1.33); C134(1.04); C51(0.90)  LDD0788  [6]
 LDCM0472  CL79 HCT 116 C119(1.43); C134(1.05); C51(0.76)  LDD0789  [6]
 LDCM0473  CL8 HCT 116 C119(1.16); C134(1.23); C51(0.54)  LDD0790  [6]
 LDCM0474  CL80 HCT 116 C119(1.05); C134(1.00); C51(1.02)  LDD0791  [6]
 LDCM0475  CL81 HCT 116 C119(0.96); C134(0.92); C51(0.82)  LDD0792  [6]
 LDCM0476  CL82 HCT 116 C119(1.03); C134(0.95); C51(0.90)  LDD0793  [6]
 LDCM0477  CL83 HCT 116 C119(1.03); C134(1.01); C51(0.78)  LDD0794  [6]
 LDCM0478  CL84 HCT 116 C119(1.28); C134(1.02); C51(0.84)  LDD0795  [6]
 LDCM0479  CL85 HCT 116 C119(0.99); C134(1.11); C51(1.02)  LDD0796  [6]
 LDCM0480  CL86 HCT 116 C119(1.21); C134(1.05); C51(1.04)  LDD0797  [6]
 LDCM0481  CL87 HCT 116 C119(0.94); C134(1.10); C51(0.90)  LDD0798  [6]
 LDCM0482  CL88 HCT 116 C119(0.96); C134(0.90); C51(0.74)  LDD0799  [6]
 LDCM0483  CL89 HCT 116 C119(1.15); C134(1.05); C51(0.73)  LDD0800  [6]
 LDCM0484  CL9 HCT 116 C119(1.26); C134(1.11); C51(0.61)  LDD0801  [6]
 LDCM0485  CL90 HCT 116 C119(0.88); C134(1.02); C51(1.17)  LDD0802  [6]
 LDCM0486  CL91 HCT 116 C119(1.05); C134(0.80); C51(1.02)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C119(0.96); C134(0.72); C51(1.34)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C119(1.06); C134(0.80); C51(1.12)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C119(1.38); C134(0.92); C51(1.21)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C119(0.96); C134(0.82); C51(0.96)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C119(0.89); C134(0.88); C51(1.17)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C119(1.34); C134(0.94); C51(0.95)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C119(1.03); C134(0.94); C51(1.15)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C119(1.11); C134(1.06); C51(1.20)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C51(0.96); C134(0.90); C78(0.98); C119(1.07)  LDD1698  [21]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C160(2.13); C134(1.06); C119(0.61)  LDD1702  [4]
 LDCM0625  F8 Ramos C119(0.67); C134(2.33)  LDD2187  [22]
 LDCM0572  Fragment10 MDA-MB-231 C134(2.01)  LDD1389  [23]
 LDCM0573  Fragment11 Ramos C134(4.33)  LDD1392  [23]
 LDCM0574  Fragment12 MDA-MB-231 C134(1.42)  LDD1468  [23]
 LDCM0575  Fragment13 MDA-MB-231 C134(1.42)  LDD1395  [23]
 LDCM0576  Fragment14 MDA-MB-231 C134(1.19)  LDD1397  [23]
 LDCM0577  Fragment15 MDA-MB-231 C134(4.37)  LDD1399  [23]
 LDCM0579  Fragment20 MDA-MB-231 C134(1.23)  LDD1402  [23]
 LDCM0580  Fragment21 MDA-MB-231 C134(1.03)  LDD1404  [23]
 LDCM0581  Fragment22 MDA-MB-231 C134(1.26)  LDD1406  [23]
 LDCM0582  Fragment23 Ramos C134(2.91)  LDD1409  [23]
 LDCM0583  Fragment24 Ramos C134(1.11)  LDD1410  [23]
 LDCM0584  Fragment25 MDA-MB-231 C134(0.92)  LDD1411  [23]
 LDCM0585  Fragment26 Ramos C134(0.97)  LDD1412  [23]
 LDCM0578  Fragment27 MDA-MB-231 C134(0.84)  LDD1401  [23]
 LDCM0586  Fragment28 MDA-MB-231 C134(1.03)  LDD1415  [23]
 LDCM0587  Fragment29 MDA-MB-231 C134(1.25)  LDD1417  [23]
 LDCM0588  Fragment30 Ramos C134(1.37)  LDD1420  [23]
 LDCM0589  Fragment31 Ramos C134(1.99)  LDD1422  [23]
 LDCM0590  Fragment32 MDA-MB-231 C134(1.52)  LDD1423  [23]
 LDCM0468  Fragment33 HCT 116 C119(1.16); C134(1.08)  LDD0785  [6]
 LDCM0592  Fragment34 MDA-MB-231 C134(0.86)  LDD1427  [23]
 LDCM0596  Fragment38 MDA-MB-231 C134(0.94)  LDD1433  [23]
 LDCM0597  Fragment39 MDA-MB-231 C134(1.37)  LDD1435  [23]
 LDCM0566  Fragment4 MDA-MB-231 C134(1.31)  LDD1378  [23]
 LDCM0598  Fragment40 MDA-MB-231 C134(0.86)  LDD1436  [23]
 LDCM0599  Fragment41 MDA-MB-231 C134(2.29)  LDD1438  [23]
 LDCM0601  Fragment43 MDA-MB-231 C134(1.13)  LDD1441  [23]
 LDCM0602  Fragment44 MDA-MB-231 C134(0.79)  LDD1443  [23]
 LDCM0603  Fragment45 MDA-MB-231 C134(2.14)  LDD1444  [23]
 LDCM0604  Fragment46 MDA-MB-231 C134(0.80)  LDD1445  [23]
 LDCM0605  Fragment47 MDA-MB-231 C134(0.91)  LDD1446  [23]
 LDCM0607  Fragment49 MDA-MB-231 C134(1.48)  LDD1448  [23]
 LDCM0608  Fragment50 MDA-MB-231 C134(1.23)  LDD1449  [23]
 LDCM0427  Fragment51 HCT 116 C119(0.79); C134(1.68); C51(0.53)  LDD0744  [6]
 LDCM0610  Fragment52 MDA-MB-231 C134(1.21)  LDD1452  [23]
 LDCM0611  Fragment53 MDA-MB-231 C134(0.96)  LDD1454  [23]
 LDCM0614  Fragment56 MDA-MB-231 C134(1.15)  LDD1458  [23]
 LDCM0569  Fragment7 MDA-MB-231 C134(1.84)  LDD1383  [23]
 LDCM0570  Fragment8 MDA-MB-231 C134(1.29)  LDD1385  [23]
 LDCM0571  Fragment9 MDA-MB-231 C134(20.00)  LDD1387  [23]
 LDCM0022  KB02 MDA-MB-231 C134(2.13)  LDD1374  [23]
 LDCM0023  KB03 MDA-MB-231 C134(1.52)  LDD1376  [23]
 LDCM0024  KB05 COLO792 C98(1.40); C134(3.38); C465(2.75); C78(1.42)  LDD3310  [24]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C134(1.11)  LDD2089  [4]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C160(1.06); C134(0.61)  LDD2093  [4]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C134(0.54)  LDD2096  [4]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C160(0.78)  LDD2097  [4]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C160(0.92); C134(0.64); C51(1.21); C119(0.90)  LDD2099  [4]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C160(0.94)  LDD2100  [4]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C160(0.82)  LDD2101  [4]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C160(0.92); C51(0.97); C119(1.12)  LDD2107  [4]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C160(0.76); C134(0.60)  LDD2109  [4]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C160(0.97); C134(0.51); C51(0.82)  LDD2111  [4]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C160(0.44)  LDD2115  [4]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C134(0.73)  LDD2116  [4]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C160(2.30); C134(1.50)  LDD2119  [4]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C134(0.58)  LDD2123  [4]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C134(1.07)  LDD2124  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C160(0.80); C134(0.56); C51(0.81); C119(1.00)  LDD2125  [4]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C160(0.90); C134(0.67)  LDD2127  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C160(1.04)  LDD2129  [4]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C160(0.57)  LDD2133  [4]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C160(0.41)  LDD2134  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C160(1.24); C134(0.40); C51(0.97); C119(0.98)  LDD2135  [4]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C160(1.02); C119(1.39)  LDD2136  [4]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C160(2.02)  LDD1700  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C160(0.76); C51(0.94); C119(0.92)  LDD2140  [4]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C134(1.02)  LDD2141  [4]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C160(2.00)  LDD2144  [4]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C160(0.68); C188(1.01)  LDD2145  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C160(0.79)  LDD2146  [4]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C160(0.50); C134(0.84)  LDD2148  [4]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C134(1.16)  LDD2151  [4]
 LDCM0627  NUDT7-COV-1 HEK-293T C134(0.21); C134(0.07)  LDD2206  [25]
 LDCM0628  OTUB2-COV-1 HEK-293T C134(1.09); C134(0.69)  LDD2207  [25]
 LDCM0131  RA190 MM1.R C134(1.36)  LDD0304  [26]
 LDCM0021  THZ1 HCT 116 C134(1.06); C119(1.04)  LDD2173  [6]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Striatin (STRN) WD repeat striatin family O43815
Striatin-3 (STRN3) WD repeat striatin family Q13033
CTTNBP2 N-terminal-like protein (CTTNBP2NL) . Q9P2B4
TRAF3-interacting JNK-activating modulator (TRAF3IP3) . Q9Y228

References

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Mass spectrometry data entry: PXD028270
3 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
22 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
23 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
24 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
25 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
26 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.