Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment12  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 87 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 20.0
 LDTP15290  5'-nucleotidase domain-containing protein 3 (NT5DC3) C276 20.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 20.0
 LDTP02074  Aldehyde dehydrogenase, mitochondrial (ALDH2) C319 20.0
 LDTP08401  All trans-polyprenyl-diphosphate synthase PDSS2 (PDSS2) C71 20.0
 LDTP10774  Elongation factor G, mitochondrial (GFM1) C153 20.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) C101 20.0
 LDTP17384  Lysine-specific demethylase RSBN1L (RSBN1L) C280 20.0
 LDTP13980  Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) C105 20.0
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 20.0
 LDTP11617  Myotubularin-related protein 12 (MTMR12) C152 20.0
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1312 20.0
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 20.0
 LDTP09126  Probable aminopeptidase NPEPL1 (NPEPL1) C81 20.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 20.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 20.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C190 20.0
 LDTP11639  RNA exonuclease 4 (REXO4) C382 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C307 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C94 20.0
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 20.0
 LDTP02502  Thioredoxin (TXN) C32 20.0
 LDTP01707  Thioredoxin domain-containing protein 12 (TXNDC12) C66 20.0
 LDTP10320  tRNA (adenine(58)-N(1))-methyltransferase catalytic subunit TRMT61A (TRMT61A) C209 20.0
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) C171 20.0
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 20.0
 LDTP12960  [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial (PDP1) C149 18.5
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 17.9
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 16.6
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 16.4
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 15.4
 LDTP04572  Dipeptidyl peptidase 1 (CTSC) C258 13.4
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 9.9
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 9.4
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 6.7
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 6.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 5.8
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 5.8
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 5.1
 LDTP10973  Thioredoxin, mitochondrial (TXN2) C90 5.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 4.6
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 4.5
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C312 4.2
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 4.1
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 4.1
 LDTP15311  Deaminated glutathione amidase (NIT1) C203 3.9
 LDTP12784  Pyroglutamyl-peptidase 1 (PGPEP1) C149 3.9
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 3.9
 LDTP03163  Sterol carrier protein 2 (SCP2) C71 3.7
 LDTP03770  Alpha-adducin (ADD1) C68 3.6
 LDTP00642  DNA-directed RNA polymerase I subunit RPA34 (POLR1G) C86 3.3
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 3.2
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 3.1
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 3.0
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 2.7
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 2.4
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 2.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.9
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) C288 1.8
 LDTP00414  Dual specificity mitogen-activated protein kinase kinase 7 (MAP2K7) C131 1.7
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.6
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 1.6
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C436 1.4
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.4
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.2
 LDTP13663  Dual specificity protein phosphatase 12 (DUSP12) C265 1.2
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 1.2
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.0
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 0.9
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 0.9
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 0.9
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.9
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 0.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.7
 LDTP04374  Dynamin-2 (DNM2) C27 0.7
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 0.7
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.7
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.6
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 0.6
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.3
 LDTP03258  Thymidylate kinase (DTYMK) C117 0.2
Transporter and channel
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 20.0
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 20.0
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) C100 20.0
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP09204  Nucleoporin NUP35 (NUP35) C255 12.4
 LDTP13498  Nuclear pore complex protein Nup50 (NUP50) C151 6.7
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 4.7
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 3.9
 LDTP05252  Clathrin heavy chain 1 (CLTC) C870 1.7
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 20.0
 LDTP01191  Zinc finger protein 217 (ZNF217) C286 20.0
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 3.3
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 2.4
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.0
Other
Click to Show/Hide to Show 55 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) C531 20.0
 LDTP04092  Crk-like protein (CRKL) C249 20.0
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 20.0
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 20.0
 LDTP09626  Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) C464 20.0
 LDTP09650  LIM domain only protein 7 (LMO7) C228 20.0
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 20.0
 LDTP16117  Mediator of RNA polymerase II transcription subunit 9 (MED9) C139 20.0
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 20.0
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) C213 20.0
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 20.0
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 20.0
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 20.0
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 20.0
 LDTP12753  Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2) C83 20.0
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 20.0
 LDTP05867  Treacle protein (TCOF1) C1298 20.0
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 20.0
 LDTP13515  Zinc finger protein 346 (ZNF346) C68 20.0
 LDTP01532  ZW10 interactor (ZWINT) C54 20.0
 LDTP12443  Anillin (ANLN) C712 16.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 16.1
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 12.9
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 7.5
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 6.8
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 6.7
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 6.5
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 5.1
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 5.0
 LDTP05867  Treacle protein (TCOF1) C38 4.7
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 4.0
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 3.5
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 3.3
 LDTP15896  Ashwin (C2orf49) C10 2.9
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 2.9
 LDTP13580  Coronin-1C (CORO1C) C420 2.2
 LDTP12571  LanC-like protein 2 (LANCL2) C187 2.0
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 1.9
 LDTP10657  Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1) C900 1.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.6
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.4
 LDTP14215  Small ribosomal subunit protein mS40 (MRPS18B) C128 1.4
 LDTP11235  Protein PAXX (PAXX) C180 1.4
 LDTP04487  Cyclin-H (CCNH) C244 1.3
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.3
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 1.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.1
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 1.1
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.1
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 0.9
 LDTP10864  Calponin-2 (CNN2) C164 0.9
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 0.8
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.6
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 0.3

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.