Details of the Target

General Information of Target

Target ID LDTP10973
Target Name Thioredoxin, mitochondrial (TXN2)
Gene Name TXN2
Gene ID 25828
Synonyms
TRX2; Thioredoxin, mitochondrial; MTRX; Mt-Trx; Thioredoxin-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASASSGPSSSVGFSSFDPAVPSCTLSSAASGIKRPMASEVLEARQDSYISLVPYASGMP
IKKIGHRSVDSSGETTYKKTTSSALKGAIQLGITHTVGSLSTKPERDVLMQDFYVVESIF
FPSEGSNLTPAHHYNDFRFKTYAPVAFRYFRELFGIRPDDYLYSLCSEPLIELCSSGASG
SLFYVSSDDEFIIKTVQHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQAGGKNIR
IVVMNNLLPRSVKMHIKYDLKGSTYKRRASQKEREKPLPTFKDLDFLQDIPDGLFLDADM
YNALCKTLQRDCLVLQSFKIMDYSLLMSIHNIDHAQREPLSSETQYSVDTRRPAPQKALY
STAMESIQGEARRGGTMETDDHMGGIPARNSKGERLLLYIGIIDILQSYRFVKKLEHSWK
ALVHDGDTVSVHRPGFYAERFQRFMCNTVFKKIPLKPSPSKKFRSGSSFSRRAGSSGNSC
ITYQPSVSGEHKAQVTTKAEVEPGVHLGRPDVLPQTPPLEEISEGSPIPDPSFSPLVGET
LQMLTTSTTLEKLEVAESEFTH
Target Bioclass
Enzyme
Family
Thioredoxin family
Subcellular location
Mitochondrion
Function Important for the control of mitochondrial reactive oxygen species homeostasis, apoptosis regulation and cell viability. Possesses a dithiol-reducing activity.
Uniprot ID
Q99757
Ensemble ID
ENST00000216185.7
HGNC ID
HGNC:17772
ChEMBL ID
CHEMBL2189153

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K102(10.00); K106(8.37); K110(10.00)  LDD0277  [1]
AHL-Pu-1
 Probe Info  		C90(5.69)  LDD0170  [2]
BDBM50514113
 Probe Info  		1.81  LDD0041  [3]
DBIA
 Probe Info  		C90(0.97)  LDD0078  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0149  [5]
IPM
 Probe Info  		N.A.  LDD0005  [6]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [7]
1c-yne
 Probe Info  		N.A.  LDD0228  [8]
1d-yne
 Probe Info  		N.A.  LDD0357  [8]
m-APA
 Probe Info  		N.A.  LDD0405  [9]
PAL-AfBPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C231
 Probe Info  		12.30  LDD1904  [10]
C289
 Probe Info  		25.99  LDD1959  [10]
C407
 Probe Info  		19.16  LDD2064  [10]
FFF probe13
 Probe Info  		6.36  LDD0476  [11]
FFF probe3
 Probe Info  		9.52  LDD0465  [11]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA DM93 C90(5.69)  LDD0170  [2]
 LDCM0214  AC1 HCT 116 C90(1.12)  LDD0531  [4]
 LDCM0215  AC10 HCT 116 C90(1.90)  LDD0532  [4]
 LDCM0216  AC100 HCT 116 C90(1.00)  LDD0533  [4]
 LDCM0217  AC101 HCT 116 C90(1.13)  LDD0534  [4]
 LDCM0218  AC102 HCT 116 C90(0.97)  LDD0535  [4]
 LDCM0219  AC103 HCT 116 C90(1.20)  LDD0536  [4]
 LDCM0220  AC104 HCT 116 C90(0.99)  LDD0537  [4]
 LDCM0221  AC105 HCT 116 C90(1.13)  LDD0538  [4]
 LDCM0222  AC106 HCT 116 C90(1.02)  LDD0539  [4]
 LDCM0223  AC107 HCT 116 C90(1.15)  LDD0540  [4]
 LDCM0224  AC108 HCT 116 C90(0.93)  LDD0541  [4]
 LDCM0225  AC109 HCT 116 C90(0.89)  LDD0542  [4]
 LDCM0226  AC11 HCT 116 C90(1.53)  LDD0543  [4]
 LDCM0227  AC110 HCT 116 C90(0.97)  LDD0544  [4]
 LDCM0228  AC111 HCT 116 C90(0.97)  LDD0545  [4]
 LDCM0229  AC112 HCT 116 C90(1.02)  LDD0546  [4]
 LDCM0230  AC113 HCT 116 C90(1.21); C93(1.05)  LDD0547  [4]
 LDCM0231  AC114 HCT 116 C90(1.46); C93(1.25)  LDD0548  [4]
 LDCM0232  AC115 HCT 116 C90(1.36); C93(1.53)  LDD0549  [4]
 LDCM0233  AC116 HCT 116 C90(1.40); C93(1.32)  LDD0550  [4]
 LDCM0234  AC117 HCT 116 C90(1.33); C93(1.42)  LDD0551  [4]
 LDCM0235  AC118 HCT 116 C90(1.18); C93(1.34)  LDD0552  [4]
 LDCM0236  AC119 HCT 116 C90(1.14); C93(1.04)  LDD0553  [4]
 LDCM0237  AC12 HCT 116 C90(1.05)  LDD0554  [4]
 LDCM0238  AC120 HCT 116 C90(1.23); C93(1.22)  LDD0555  [4]
 LDCM0239  AC121 HCT 116 C90(1.06); C93(0.93)  LDD0556  [4]
 LDCM0240  AC122 HCT 116 C90(1.10); C93(0.98)  LDD0557  [4]
 LDCM0241  AC123 HCT 116 C90(1.25); C93(1.52)  LDD0558  [4]
 LDCM0242  AC124 HCT 116 C90(1.25); C93(1.26)  LDD0559  [4]
 LDCM0243  AC125 HCT 116 C90(1.20); C93(1.26)  LDD0560  [4]
 LDCM0244  AC126 HCT 116 C90(1.32); C93(1.21)  LDD0561  [4]
 LDCM0245  AC127 HCT 116 C90(1.41); C93(1.34)  LDD0562  [4]
 LDCM0246  AC128 HCT 116 C90(1.05); C93(0.77)  LDD0563  [4]
 LDCM0247  AC129 HCT 116 C90(0.98); C93(0.72)  LDD0564  [4]
 LDCM0249  AC130 HCT 116 C90(1.02); C93(0.67)  LDD0566  [4]
 LDCM0250  AC131 HCT 116 C90(1.03); C93(0.90)  LDD0567  [4]
 LDCM0251  AC132 HCT 116 C90(1.00); C93(0.99)  LDD0568  [4]
 LDCM0252  AC133 HCT 116 C90(0.97); C93(0.80)  LDD0569  [4]
 LDCM0253  AC134 HCT 116 C90(1.04); C93(0.68)  LDD0570  [4]
 LDCM0254  AC135 HCT 116 C90(1.09); C93(0.62)  LDD0571  [4]
 LDCM0255  AC136 HCT 116 C90(0.96); C93(0.71)  LDD0572  [4]
 LDCM0256  AC137 HCT 116 C90(0.95); C93(0.89)  LDD0573  [4]
 LDCM0257  AC138 HCT 116 C90(1.08); C93(0.72)  LDD0574  [4]
 LDCM0258  AC139 HCT 116 C90(0.93); C93(0.74)  LDD0575  [4]
 LDCM0259  AC14 HCT 116 C90(1.14)  LDD0576  [4]
 LDCM0260  AC140 HCT 116 C90(1.04); C93(0.68)  LDD0577  [4]
 LDCM0261  AC141 HCT 116 C90(1.06); C93(0.72)  LDD0578  [4]
 LDCM0262  AC142 HCT 116 C90(0.97); C93(0.74)  LDD0579  [4]
 LDCM0263  AC143 HCT 116 C90(1.18); C93(1.09)  LDD0580  [4]
 LDCM0264  AC144 HCT 116 C90(1.11); C93(1.51)  LDD0581  [4]
 LDCM0265  AC145 HCT 116 C90(1.00); C93(1.28)  LDD0582  [4]
 LDCM0266  AC146 HCT 116 C90(1.28); C93(1.39)  LDD0583  [4]
 LDCM0267  AC147 HCT 116 C93(1.09); C90(1.27)  LDD0584  [4]
 LDCM0268  AC148 HCT 116 C93(1.11); C90(1.42)  LDD0585  [4]
 LDCM0269  AC149 HCT 116 C93(1.36); C90(1.41)  LDD0586  [4]
 LDCM0270  AC15 HCT 116 C90(1.38)  LDD0587  [4]
 LDCM0271  AC150 HCT 116 C93(1.08); C90(1.18)  LDD0588  [4]
 LDCM0272  AC151 HCT 116 C90(1.14); C93(1.26)  LDD0589  [4]
 LDCM0273  AC152 HCT 116 C93(1.19); C90(1.40)  LDD0590  [4]
 LDCM0274  AC153 HCT 116 C90(1.25); C93(1.80)  LDD0591  [4]
 LDCM0621  AC154 HCT 116 C90(1.10); C93(1.24)  LDD2158  [4]
 LDCM0622  AC155 HCT 116 C90(1.17); C93(1.26)  LDD2159  [4]
 LDCM0623  AC156 HCT 116 C90(1.02); C93(1.30)  LDD2160  [4]
 LDCM0624  AC157 HCT 116 C90(1.05); C93(1.49)  LDD2161  [4]
 LDCM0276  AC17 HCT 116 C93(1.07); C90(1.21)  LDD0593  [4]
 LDCM0277  AC18 HCT 116 C93(1.23); C90(1.23)  LDD0594  [4]
 LDCM0278  AC19 HCT 116 C90(1.21); C93(1.22)  LDD0595  [4]
 LDCM0279  AC2 HCT 116 C90(1.35)  LDD0596  [4]
 LDCM0280  AC20 HCT 116 C93(1.07); C90(1.18)  LDD0597  [4]
 LDCM0281  AC21 HCT 116 C93(1.06); C90(1.10)  LDD0598  [4]
 LDCM0282  AC22 HCT 116 C93(1.06); C90(1.08)  LDD0599  [4]
 LDCM0283  AC23 HCT 116 C93(1.26); C90(1.29)  LDD0600  [4]
 LDCM0284  AC24 HCT 116 C90(1.34); C93(1.47)  LDD0601  [4]
 LDCM0285  AC25 HCT 116 C93(0.94); C90(0.96)  LDD0602  [4]
 LDCM0286  AC26 HCT 116 C93(0.94); C90(1.16)  LDD0603  [4]
 LDCM0287  AC27 HCT 116 C93(0.93); C90(0.96)  LDD0604  [4]
 LDCM0288  AC28 HCT 116 C90(1.19); C93(1.25)  LDD0605  [4]
 LDCM0289  AC29 HCT 116 C93(1.06); C90(1.13)  LDD0606  [4]
 LDCM0290  AC3 HCT 116 C90(1.03)  LDD0607  [4]
 LDCM0291  AC30 HCT 116 C93(0.73); C90(1.02)  LDD0608  [4]
 LDCM0292  AC31 HCT 116 C93(0.77); C90(1.08)  LDD0609  [4]
 LDCM0293  AC32 HCT 116 C93(0.90); C90(1.27)  LDD0610  [4]
 LDCM0294  AC33 HCT 116 C93(1.04); C90(1.19)  LDD0611  [4]
 LDCM0295  AC34 HCT 116 C93(1.15); C90(1.30)  LDD0612  [4]
 LDCM0296  AC35 HCT 116 C90(0.89); C93(0.93)  LDD0613  [4]
 LDCM0297  AC36 HCT 116 C93(0.87); C90(0.98)  LDD0614  [4]
 LDCM0298  AC37 HCT 116 C93(0.80); C90(0.84)  LDD0615  [4]
 LDCM0299  AC38 HCT 116 C90(0.86); C93(1.00)  LDD0616  [4]
 LDCM0300  AC39 HCT 116 C90(0.93); C93(0.95)  LDD0617  [4]
 LDCM0301  AC4 HCT 116 C90(1.11)  LDD0618  [4]
 LDCM0302  AC40 HCT 116 C90(1.00); C93(1.08)  LDD0619  [4]
 LDCM0303  AC41 HCT 116 C93(0.85); C90(1.12)  LDD0620  [4]
 LDCM0304  AC42 HCT 116 C93(1.07); C90(1.09)  LDD0621  [4]
 LDCM0305  AC43 HCT 116 C93(0.94); C90(1.03)  LDD0622  [4]
 LDCM0306  AC44 HCT 116 C93(0.81); C90(1.01)  LDD0623  [4]
 LDCM0307  AC45 HCT 116 C90(1.16); C93(1.23)  LDD0624  [4]
 LDCM0308  AC46 HCT 116 C90(0.91)  LDD0625  [4]
 LDCM0309  AC47 HCT 116 C90(0.91)  LDD0626  [4]
 LDCM0310  AC48 HCT 116 C90(0.78)  LDD0627  [4]
 LDCM0311  AC49 HCT 116 C90(1.07)  LDD0628  [4]
 LDCM0312  AC5 HCT 116 C90(1.42)  LDD0629  [4]
 LDCM0313  AC50 HCT 116 C90(1.09)  LDD0630  [4]
 LDCM0314  AC51 HCT 116 C90(0.80)  LDD0631  [4]
 LDCM0315  AC52 HCT 116 C90(0.85)  LDD0632  [4]
 LDCM0316  AC53 HCT 116 C90(1.11)  LDD0633  [4]
 LDCM0317  AC54 HCT 116 C90(0.92)  LDD0634  [4]
 LDCM0318  AC55 HCT 116 C90(1.02)  LDD0635  [4]
 LDCM0319  AC56 HCT 116 C90(1.18)  LDD0636  [4]
 LDCM0320  AC57 HCT 116 C90(1.24)  LDD0637  [4]
 LDCM0321  AC58 HCT 116 C90(1.11)  LDD0638  [4]
 LDCM0322  AC59 HCT 116 C90(1.27)  LDD0639  [4]
 LDCM0323  AC6 HCT 116 C90(1.37)  LDD0640  [4]
 LDCM0324  AC60 HCT 116 C90(1.61)  LDD0641  [4]
 LDCM0325  AC61 HCT 116 C90(1.38)  LDD0642  [4]
 LDCM0326  AC62 HCT 116 C90(1.55)  LDD0643  [4]
 LDCM0327  AC63 HCT 116 C90(1.39)  LDD0644  [4]
 LDCM0328  AC64 HCT 116 C90(1.59)  LDD0645  [4]
 LDCM0329  AC65 HCT 116 C90(1.46)  LDD0646  [4]
 LDCM0330  AC66 HCT 116 C90(1.47)  LDD0647  [4]
 LDCM0331  AC67 HCT 116 C90(1.30)  LDD0648  [4]
 LDCM0332  AC68 HCT 116 C90(1.05)  LDD0649  [4]
 LDCM0333  AC69 HCT 116 C90(1.11)  LDD0650  [4]
 LDCM0334  AC7 HCT 116 C90(1.68)  LDD0651  [4]
 LDCM0335  AC70 HCT 116 C90(1.06)  LDD0652  [4]
 LDCM0336  AC71 HCT 116 C90(0.97)  LDD0653  [4]
 LDCM0337  AC72 HCT 116 C90(1.16)  LDD0654  [4]
 LDCM0338  AC73 HCT 116 C90(1.32)  LDD0655  [4]
 LDCM0339  AC74 HCT 116 C90(1.38)  LDD0656  [4]
 LDCM0340  AC75 HCT 116 C90(1.38)  LDD0657  [4]
 LDCM0341  AC76 HCT 116 C90(1.17)  LDD0658  [4]
 LDCM0342  AC77 HCT 116 C90(1.28)  LDD0659  [4]
 LDCM0343  AC78 HCT 116 C90(1.00)  LDD0660  [4]
 LDCM0344  AC79 HCT 116 C90(1.20)  LDD0661  [4]
 LDCM0345  AC8 HCT 116 C90(1.55)  LDD0662  [4]
 LDCM0346  AC80 HCT 116 C90(0.97)  LDD0663  [4]
 LDCM0347  AC81 HCT 116 C90(1.09)  LDD0664  [4]
 LDCM0348  AC82 HCT 116 C90(1.46)  LDD0665  [4]
 LDCM0349  AC83 HCT 116 C93(1.08); C90(1.40)  LDD0666  [4]
 LDCM0350  AC84 HCT 116 C93(0.89); C90(1.17)  LDD0667  [4]
 LDCM0351  AC85 HCT 116 C93(1.15); C90(1.16)  LDD0668  [4]
 LDCM0352  AC86 HCT 116 C90(1.11); C93(1.11)  LDD0669  [4]
 LDCM0353  AC87 HCT 116 C90(0.94); C93(0.96)  LDD0670  [4]
 LDCM0354  AC88 HCT 116 C93(0.93); C90(0.97)  LDD0671  [4]
 LDCM0355  AC89 HCT 116 C90(1.04); C93(1.14)  LDD0672  [4]
 LDCM0357  AC90 HCT 116 C90(0.74); C93(1.35)  LDD0674  [4]
 LDCM0358  AC91 HCT 116 C93(0.96); C90(1.29)  LDD0675  [4]
 LDCM0359  AC92 HCT 116 C90(0.83); C93(1.01)  LDD0676  [4]
 LDCM0360  AC93 HCT 116 C90(0.78); C93(1.01)  LDD0677  [4]
 LDCM0361  AC94 HCT 116 C93(0.77); C90(1.02)  LDD0678  [4]
 LDCM0362  AC95 HCT 116 C93(0.95); C90(1.15)  LDD0679  [4]
 LDCM0363  AC96 HCT 116 C93(0.88); C90(0.95)  LDD0680  [4]
 LDCM0364  AC97 HCT 116 C93(1.11); C90(1.32)  LDD0681  [4]
 LDCM0365  AC98 HCT 116 C90(1.89)  LDD0682  [4]
 LDCM0366  AC99 HCT 116 C90(0.95)  LDD0683  [4]
 LDCM0248  AKOS034007472 HCT 116 C90(1.15)  LDD0565  [4]
 LDCM0356  AKOS034007680 HCT 116 C90(1.43)  LDD0673  [4]
 LDCM0275  AKOS034007705 HCT 116 C90(1.56)  LDD0592  [4]
 LDCM0156  Aniline NCI-H1299 N.A.  LDD0405  [9]
 LDCM0020  ARS-1620 HCC44 C90(0.97)  LDD0078  [4]
 LDCM0367  CL1 HCT 116 C90(3.24)  LDD0684  [4]
 LDCM0368  CL10 HCT 116 C90(2.46)  LDD0685  [4]
 LDCM0369  CL100 HCT 116 C90(1.17)  LDD0686  [4]
 LDCM0370  CL101 HCT 116 C90(1.51)  LDD0687  [4]
 LDCM0371  CL102 HCT 116 C90(2.55)  LDD0688  [4]
 LDCM0372  CL103 HCT 116 C90(1.38)  LDD0689  [4]
 LDCM0373  CL104 HCT 116 C90(1.41)  LDD0690  [4]
 LDCM0374  CL105 HCT 116 C90(1.33); C93(1.61)  LDD0691  [4]
 LDCM0375  CL106 HCT 116 C93(0.94); C90(1.40)  LDD0692  [4]
 LDCM0376  CL107 HCT 116 C93(0.98); C90(1.28)  LDD0693  [4]
 LDCM0377  CL108 HCT 116 C93(1.58); C90(4.05)  LDD0694  [4]
 LDCM0378  CL109 HCT 116 C90(1.48); C93(1.79)  LDD0695  [4]
 LDCM0379  CL11 HCT 116 C90(2.68)  LDD0696  [4]
 LDCM0380  CL110 HCT 116 C90(1.19); C93(1.30)  LDD0697  [4]
 LDCM0381  CL111 HCT 116 C93(1.34); C90(1.55)  LDD0698  [4]
 LDCM0382  CL112 HCT 116 C90(1.03); C93(1.09)  LDD0699  [4]
 LDCM0383  CL113 HCT 116 C93(1.05); C90(1.30)  LDD0700  [4]
 LDCM0384  CL114 HCT 116 C93(0.93); C90(1.08)  LDD0701  [4]
 LDCM0385  CL115 HCT 116 C93(1.65); C90(5.72)  LDD0702  [4]
 LDCM0386  CL116 HCT 116 C93(1.11); C90(1.80)  LDD0703  [4]
 LDCM0387  CL117 HCT 116 C93(1.50); C90(3.17)  LDD0704  [4]
 LDCM0388  CL118 HCT 116 C93(1.32); C90(2.44)  LDD0705  [4]
 LDCM0389  CL119 HCT 116 C90(1.03); C93(1.19)  LDD0706  [4]
 LDCM0390  CL12 HCT 116 C90(1.28)  LDD0707  [4]
 LDCM0391  CL120 HCT 116 C93(0.86); C90(1.01)  LDD0708  [4]
 LDCM0392  CL121 HCT 116 C90(0.63)  LDD0709  [4]
 LDCM0393  CL122 HCT 116 C90(2.41)  LDD0710  [4]
 LDCM0394  CL123 HCT 116 C90(2.01)  LDD0711  [4]
 LDCM0395  CL124 HCT 116 C90(1.33)  LDD0712  [4]
 LDCM0396  CL125 HCT 116 C90(1.23)  LDD0713  [4]
 LDCM0397  CL126 HCT 116 C90(3.53)  LDD0714  [4]
 LDCM0398  CL127 HCT 116 C90(2.98)  LDD0715  [4]
 LDCM0399  CL128 HCT 116 C90(1.25)  LDD0716  [4]
 LDCM0400  CL13 HCT 116 C90(3.84)  LDD0717  [4]
 LDCM0401  CL14 HCT 116 C90(1.74)  LDD0718  [4]
 LDCM0402  CL15 HCT 116 C90(2.18)  LDD0719  [4]
 LDCM0403  CL16 HCT 116 C90(1.91)  LDD0720  [4]
 LDCM0404  CL17 HCT 116 C90(2.04)  LDD0721  [4]
 LDCM0405  CL18 HCT 116 C90(2.27)  LDD0722  [4]
 LDCM0406  CL19 HCT 116 C90(3.17)  LDD0723  [4]
 LDCM0407  CL2 HCT 116 C90(3.96)  LDD0724  [4]
 LDCM0408  CL20 HCT 116 C90(1.24)  LDD0725  [4]
 LDCM0409  CL21 HCT 116 C90(0.97)  LDD0726  [4]
 LDCM0410  CL22 HCT 116 C90(4.23)  LDD0727  [4]
 LDCM0411  CL23 HCT 116 C90(1.06)  LDD0728  [4]
 LDCM0412  CL24 HCT 116 C90(1.07)  LDD0729  [4]
 LDCM0413  CL25 HCT 116 C90(1.19)  LDD0730  [4]
 LDCM0414  CL26 HCT 116 C90(1.94)  LDD0731  [4]
 LDCM0415  CL27 HCT 116 C90(10.08)  LDD0732  [4]
 LDCM0416  CL28 HCT 116 C90(2.61)  LDD0733  [4]
 LDCM0417  CL29 HCT 116 C90(1.05)  LDD0734  [4]
 LDCM0418  CL3 HCT 116 C90(1.61)  LDD0735  [4]
 LDCM0419  CL30 HCT 116 C90(1.07)  LDD0736  [4]
 LDCM0420  CL31 HCT 116 C90(3.95)  LDD0737  [4]
 LDCM0421  CL32 HCT 116 C90(3.60)  LDD0738  [4]
 LDCM0422  CL33 HCT 116 C90(3.80)  LDD0739  [4]
 LDCM0423  CL34 HCT 116 C90(3.51)  LDD0740  [4]
 LDCM0424  CL35 HCT 116 C90(1.81)  LDD0741  [4]
 LDCM0425  CL36 HCT 116 C90(2.69)  LDD0742  [4]
 LDCM0426  CL37 HCT 116 C90(2.42)  LDD0743  [4]
 LDCM0428  CL39 HCT 116 C90(3.25)  LDD0745  [4]
 LDCM0429  CL4 HCT 116 C90(2.11)  LDD0746  [4]
 LDCM0430  CL40 HCT 116 C90(3.19)  LDD0747  [4]
 LDCM0431  CL41 HCT 116 C90(1.99)  LDD0748  [4]
 LDCM0432  CL42 HCT 116 C90(2.03)  LDD0749  [4]
 LDCM0433  CL43 HCT 116 C90(3.10)  LDD0750  [4]
 LDCM0434  CL44 HCT 116 C90(2.92)  LDD0751  [4]
 LDCM0435  CL45 HCT 116 C90(1.83)  LDD0752  [4]
 LDCM0436  CL46 HCT 116 C90(2.01)  LDD0753  [4]
 LDCM0437  CL47 HCT 116 C90(3.52)  LDD0754  [4]
 LDCM0438  CL48 HCT 116 C90(1.23)  LDD0755  [4]
 LDCM0439  CL49 HCT 116 C90(1.36)  LDD0756  [4]
 LDCM0440  CL5 HCT 116 C90(1.69)  LDD0757  [4]
 LDCM0441  CL50 HCT 116 C90(0.97)  LDD0758  [4]
 LDCM0442  CL51 HCT 116 C90(0.84)  LDD0759  [4]
 LDCM0443  CL52 HCT 116 C90(1.07)  LDD0760  [4]
 LDCM0444  CL53 HCT 116 C90(1.04)  LDD0761  [4]
 LDCM0445  CL54 HCT 116 C90(1.80)  LDD0762  [4]
 LDCM0446  CL55 HCT 116 C90(1.88)  LDD0763  [4]
 LDCM0447  CL56 HCT 116 C90(3.87)  LDD0764  [4]
 LDCM0448  CL57 HCT 116 C90(1.92)  LDD0765  [4]
 LDCM0449  CL58 HCT 116 C90(1.09)  LDD0766  [4]
 LDCM0450  CL59 HCT 116 C90(1.17)  LDD0767  [4]
 LDCM0451  CL6 HCT 116 C90(1.06)  LDD0768  [4]
 LDCM0452  CL60 HCT 116 C90(2.18)  LDD0769  [4]
 LDCM0453  CL61 HCT 116 C90(1.15)  LDD0770  [4]
 LDCM0454  CL62 HCT 116 C90(2.62)  LDD0771  [4]
 LDCM0455  CL63 HCT 116 C90(1.18)  LDD0772  [4]
 LDCM0456  CL64 HCT 116 C90(1.18)  LDD0773  [4]
 LDCM0457  CL65 HCT 116 C90(2.32)  LDD0774  [4]
 LDCM0458  CL66 HCT 116 C90(3.24)  LDD0775  [4]
 LDCM0459  CL67 HCT 116 C90(1.41)  LDD0776  [4]
 LDCM0460  CL68 HCT 116 C90(4.76)  LDD0777  [4]
 LDCM0461  CL69 HCT 116 C90(2.62)  LDD0778  [4]
 LDCM0462  CL7 HCT 116 C90(3.73)  LDD0779  [4]
 LDCM0463  CL70 HCT 116 C90(1.68)  LDD0780  [4]
 LDCM0464  CL71 HCT 116 C90(1.40)  LDD0781  [4]
 LDCM0465  CL72 HCT 116 C90(1.27)  LDD0782  [4]
 LDCM0466  CL73 HCT 116 C90(1.36)  LDD0783  [4]
 LDCM0467  CL74 HCT 116 C90(1.37)  LDD0784  [4]
 LDCM0469  CL76 HCT 116 C90(2.19)  LDD0786  [4]
 LDCM0470  CL77 HCT 116 C90(1.52)  LDD0787  [4]
 LDCM0471  CL78 HCT 116 C90(3.01)  LDD0788  [4]
 LDCM0472  CL79 HCT 116 C90(4.50)  LDD0789  [4]
 LDCM0473  CL8 HCT 116 C90(3.98)  LDD0790  [4]
 LDCM0474  CL80 HCT 116 C90(2.47)  LDD0791  [4]
 LDCM0475  CL81 HCT 116 C90(2.20)  LDD0792  [4]
 LDCM0476  CL82 HCT 116 C90(4.47)  LDD0793  [4]
 LDCM0477  CL83 HCT 116 C90(2.41)  LDD0794  [4]
 LDCM0478  CL84 HCT 116 C90(2.39)  LDD0795  [4]
 LDCM0479  CL85 HCT 116 C90(2.24)  LDD0796  [4]
 LDCM0480  CL86 HCT 116 C90(2.19)  LDD0797  [4]
 LDCM0481  CL87 HCT 116 C90(4.30)  LDD0798  [4]
 LDCM0482  CL88 HCT 116 C90(1.63)  LDD0799  [4]
 LDCM0483  CL89 HCT 116 C90(4.33)  LDD0800  [4]
 LDCM0484  CL9 HCT 116 C90(2.33)  LDD0801  [4]
 LDCM0485  CL90 HCT 116 C90(6.06)  LDD0802  [4]
 LDCM0486  CL91 HCT 116 C90(1.79)  LDD0803  [4]
 LDCM0487  CL92 HCT 116 C90(3.59)  LDD0804  [4]
 LDCM0488  CL93 HCT 116 C90(2.21)  LDD0805  [4]
 LDCM0489  CL94 HCT 116 C90(1.81)  LDD0806  [4]
 LDCM0490  CL95 HCT 116 C90(1.46)  LDD0807  [4]
 LDCM0491  CL96 HCT 116 C90(1.16)  LDD0808  [4]
 LDCM0492  CL97 HCT 116 C90(1.13)  LDD0809  [4]
 LDCM0493  CL98 HCT 116 C90(1.96)  LDD0810  [4]
 LDCM0494  CL99 HCT 116 C90(4.09)  LDD0811  [4]
 LDCM0495  E2913 HEK-293T C93(1.18); C90(1.14)  LDD1698  [12]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C90(0.97)  LDD1702  [13]
 LDCM0573  Fragment11 MDA-MB-231 C90(2.69)  LDD1467  [14]
 LDCM0574  Fragment12 MDA-MB-231 C90(4.98)  LDD1468  [14]
 LDCM0576  Fragment14 MDA-MB-231 C90(3.22)  LDD1471  [14]
 LDCM0580  Fragment21 MDA-MB-231 C90(4.27)  LDD1473  [14]
 LDCM0578  Fragment27 MDA-MB-231 C90(6.32)  LDD1474  [14]
 LDCM0587  Fragment29 Ramos C90(1.56)  LDD1476  [14]
 LDCM0589  Fragment31 MDA-MB-231 C90(1.37)  LDD1477  [14]
 LDCM0468  Fragment33 HCT 116 C90(4.83)  LDD0785  [4]
 LDCM0596  Fragment38 MDA-MB-231 C90(3.64)  LDD1480  [14]
 LDCM0566  Fragment4 MDA-MB-231 C90(3.64)  LDD1461  [14]
 LDCM0599  Fragment41 MDA-MB-231 C90(0.48)  LDD1481  [14]
 LDCM0603  Fragment45 MDA-MB-231 C90(6.72)  LDD1482  [14]
 LDCM0427  Fragment51 HCT 116 C90(3.63)  LDD0744  [4]
 LDCM0570  Fragment8 MDA-MB-231 C90(4.46)  LDD1462  [14]
 LDCM0571  Fragment9 MDA-MB-231 C90(20.00)  LDD1463  [14]
 LDCM0022  KB02 HCT 116 C90(2.76); C93(2.76)  LDD0080  [4]
 LDCM0023  KB03 HCT 116 C90(3.61); C93(3.61)  LDD0081  [4]
 LDCM0024  KB05 HCT 116 C90(2.97); C93(2.97)  LDD0082  [4]
 LDCM0131  RA190 MM1.R C90(1.61); C93(1.61)  LDD0304  [15]
 LDCM0021  THZ1 HCT 116 C90(1.15); C93(1.15)  LDD2173  [4]
 LDCM0002  Ward_cp1 U2OS 1.81  LDD0041  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Diamine acetyltransferase 1 (SAT1) Acetyltransferase family P21673
Deoxycytidylate deaminase (DCTD) Cytidine and deoxycytidylate deaminase family P32321
Phosphopantothenoylcysteine decarboxylase (PPCDC) HFCD (homooligomeric flavin containing Cys decarboxylase) superfamily Q96CD2
Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) Glyoxalase II family O95571
Protein-associating with the carboxyl-terminal domain of ezrin (SCYL3) Protein kinase superfamily Q8IZE3
Ribose-5-phosphate isomerase (RPIA) Ribose 5-phosphate isomerase family P49247
GTP-binding protein 2 (GTPBP2) Classic translation factor GTPase family Q9BX10
E3 ubiquitin-protein ligase TRIM21 (TRIM21) TRIM/RBCC family P19474
E3 ubiquitin-protein ligase CHIP (STUB1) . Q9UNE7
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AP-2 complex subunit beta (AP2B1) Adaptor complexes large subunit family P63010
Receptor expression-enhancing protein 6 (REEP6) DP1 family Q96HR9
Huntingtin (HTT) Huntingtin family P42858
MyoD family inhibitor (MDFI) MDFI family Q99750
Peroxisomal biogenesis factor 19 (PEX19) Peroxin-19 family P40855
Rab5 GDP/GTP exchange factor (RABGEF1) . Q9UJ41
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 3 protein (DDIT3) BZIP family P35638
G protein-coupled receptor associated sorting protein 3 (GPRASP3) GPRASP family Q6PI77
G-protein coupled receptor-associated sorting protein 2 (GPRASP2) GPRASP family Q96D09
Zinc finger and BTB domain-containing protein 14 (ZBTB14) Krueppel C2H2-type zinc-finger protein family O43829
Other
Click To Hide/Show 42 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ABI gene family member 3 (ABI3) ABI family Q9P2A4
Neutrophil gelatinase-associated lipocalin (LCN2) Lipocalin family P80188
Protein FAM9B (FAM9B) FAM9 family Q8IZU0
Golgin subfamily A member 6-like protein 9 (GOLGA6L9) GOLGA6 family A6NEM1
HAUS augmin-like complex subunit 1 (HAUS1) HAUS1 family Q96CS2
HAUS augmin-like complex subunit 8 (HAUS8) HAUS8 family Q9BT25
Keratin, type I cytoskeletal 27 (KRT27) Intermediate filament family Q7Z3Y8
Keratin, type I cytoskeletal 40 (KRT40) Intermediate filament family Q6A162
Microtubule-associated protein RP/EB family member 2 (MAPRE2) MAPRE family Q15555
Microtubule-associated protein RP/EB family member 3 (MAPRE3) MAPRE family Q9UPY8
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
MORF4 family-associated protein 1-like 1 (MRFAP1L1) MORF4 family-associated protein family Q96HT8
Microtubule-associated tumor suppressor candidate 2 (MTUS2) MTUS1 family Q5JR59
Outer dynein arm-docking complex subunit 1 (ODAD1) ODA1/DCC2 family Q96M63
Proteasome activator complex subunit 3 (PSME3) PA28 family P61289
Pro-opiomelanocortin (POMC) POMC family P01189
Charged multivesicular body protein 1a (CHMP1A) SNF7 family Q9HD42
Spectrin alpha chain, erythrocytic 1 (SPTA1) Spectrin family P02549
Pre-mRNA-splicing factor SPF27 (BCAS2) SPF27 family O75934
Microtubule nucleation factor SSNA1 (SSNA1) SSNA1 family O43805
CST complex subunit STN1 (STN1) STN1 family Q9H668
Synaptonemal complex central element protein 1 (SYCE1) SYCE family Q8N0S2
Tuftelin-interacting protein 11 (TFIP11) TFP11/STIP family Q9UBB9
TRAF-interacting protein with FHA domain-containing protein A (TIFA) TIFA family Q96CG3
Tropomodulin-4 (TMOD4) Tropomodulin family Q9NZQ9
Vacuolar protein sorting-associated protein 52 homolog (VPS52) VPS52 family Q8N1B4
Thyroid receptor-interacting protein 6 (TRIP6) Zyxin/ajuba family Q15654
Calcium and integrin-binding family member 4 (CIB4) . A0PJX0
Cell division cycle-associated protein 4 (CDCA4) . Q9BXL8
Centrosomal protein of 70 kDa (CEP70) . Q8NHQ1
CGG triplet repeat-binding protein 1 (CGGBP1) . Q9UFW8
Four and a half LIM domains protein 5 (FHL5) . Q5TD97
Melanoma-associated antigen 4 (MAGEA4) . P43358
Melanoma-associated antigen B2 (MAGEB2) . O15479
Mirror-image polydactyly gene 1 protein (MIPOL1) . Q8TD10
Protein phosphatase 1 regulatory inhibitor subunit 16B (PPP1R16B) . Q96T49
RNA-binding protein 45 (RBM45) . Q8IUH3
Tetratricopeptide repeat protein 32 (TTC32) . Q5I0X7
Type-1 angiotensin II receptor-associated protein (AGTRAP) . Q6RW13
Ubiquinol-cytochrome c reductase complex assembly factor 2 (UQCC2) . Q9BRT2
Uncharacterized protein CCDC197 (CCDC197) . Q8NCU1
Zinc finger MYND domain-containing protein 12 (ZMYND12) . Q9H0C1

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
3 Quantitative Chemical Proteomic Profiling of Ubiquitin Specific Proteases in Intact Cancer Cells. ACS Chem Biol. 2016 Dec 16;11(12):3268-3272. doi: 10.1021/acschembio.6b00766. Epub 2016 Oct 31.
4 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
5 Sequence-Based Prediction of Cysteine Reactivity Using Machine Learning. Biochemistry. 2018 Jan 30;57(4):451-460. doi: 10.1021/acs.biochem.7b00897. Epub 2017 Oct 26.
6 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
7 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
8 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
9 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
10 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
11 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
12 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
13 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
14 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
15 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.