Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment9  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 63 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) C288 20.0
 LDTP17247  5'-nucleotidase domain-containing protein 1 (NT5DC1) C119 20.0
 LDTP10386  ERO1-like protein alpha (ERO1A) C37 20.0
 LDTP16025  Ketosamine-3-kinase (FN3KRP) C24 20.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 20.0
 LDTP14092  Protein phosphatase methylesterase 1 (PPME1) C381 20.0
 LDTP02502  Thioredoxin (TXN) C32 20.0
 LDTP10973  Thioredoxin, mitochondrial (TXN2) C90 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 19.5
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 14.1
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 10.3
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 10.0
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) C101 9.0
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 7.7
 LDTP03258  Thymidylate kinase (DTYMK) C117 7.3
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 7.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 6.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 5.8
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 5.1
 LDTP02223  Cathepsin B (CTSB) C211 5.0
 LDTP02493  Serine/threonine-protein kinase A-Raf (ARAF) C597 5.0
 LDTP03400  Deoxycytidine kinase (DCK) C9 4.9
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 4.5
 LDTP03770  Alpha-adducin (ADD1) C68 4.3
 LDTP12166  Ras-related GTP-binding protein C (RRAGC) C377 4.3
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 4.3
 LDTP05992  Bleomycin hydrolase (BLMH) C73 3.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 3.8
 LDTP00013  Ubiquitin-like modifier-activating enzyme 6 (UBA6) C347 3.3
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 3.3
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 3.3
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 3.3
 LDTP05289  AMP deaminase 2 (AMPD2) C107 3.1
 LDTP05795  Nucleoside diphosphate kinase 3 (NME3) C158 2.7
 LDTP05859  Integrin-linked protein kinase (ILK) C346 2.7
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C161 2.6
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 2.6
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 2.4
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 2.3
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 2.1
 LDTP04471  Ribosomal protein S6 kinase alpha-3 (RPS6KA3) C436 2.1
 LDTP13527  Aspartyl aminopeptidase (DNPEP) C144 2.1
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 2.1
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 2.0
 LDTP05954  GDP-L-fucose synthase (GFUS) C116 1.9
 LDTP12405  Fructose-2,6-bisphosphatase TIGAR (TIGAR) C114 1.9
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 1.9
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.7
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 1.7
 LDTP19669  Threonine synthase-like 1 (THNSL1) C324 1.6
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 1.5
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 1.5
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.4
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 1.4
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 1.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.3
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 1.2
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.2
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.2
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 1.1
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.7
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C312 0.5
Transporter and channel
Click to Show/Hide to Show 9 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP01689  Chloride intracellular channel protein 3 (CLIC3) C22 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 20.0
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) C100 15.4
 LDTP02735  G2/mitotic-specific cyclin-B1 (CCNB1) C238 3.7
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 3.6
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 3.0
 LDTP05252  Clathrin heavy chain 1 (CLTC) C870 2.8
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 2.6
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 6.6
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 3.1
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 2.9
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.4
Other
Click to Show/Hide to Show 41 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 20.0
 LDTP13964  MOB-like protein phocein (MOB4) C134 20.0
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 20.0
 LDTP12412  Reticulon-4 (RTN4) C1101 20.0
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 17.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 10.1
 LDTP10252  Elongator complex protein 4 (ELP4) C218 8.4
 LDTP18494  Tropomodulin-3 (TMOD3) C132 7.6
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 6.8
 LDTP04092  Crk-like protein (CRKL) C249 6.7
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 6.1
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 5.7
 LDTP00306  Pescadillo homolog (PES1) C272 5.0
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 4.7
 LDTP00229  Copper transport protein ATOX1 (ATOX1) C12 4.7
 LDTP10864  Calponin-2 (CNN2) C164 4.7
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 4.3
 LDTP14179  Cytosolic Fe-S cluster assembly factor NUBP2 (NUBP2) C72 4.0
 LDTP19787  RING finger protein 214 (RNF214) C655 4.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 3.7
 LDTP01532  ZW10 interactor (ZWINT) C54 3.7
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C518 3.4
 LDTP07755  Dynamin-binding protein (DNMBP) C691 3.4
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 3.2
 LDTP12443  Anillin (ANLN) C712 3.1
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 3.0
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 2.8
 LDTP11235  Protein PAXX (PAXX) C180 2.8
 LDTP12571  LanC-like protein 2 (LANCL2) C187 2.5
 LDTP13906  Polymerase delta-interacting protein 2 (POLDIP2) C143 2.3
 LDTP10781  NudC domain-containing protein 1 (NUDCD1) C376 2.2
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 2.2
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 2.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 2.1
 LDTP13580  Coronin-1C (CORO1C) C420 2.0
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 1.9
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.9
 LDTP01011  Protein diaphanous homolog 1 (DIAPH1) C1227 1.5
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.4
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.3
 LDTP06330  Plectin (PLEC) C4574 0.8

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.