Details of the Target

General Information of Target

Target ID LDTP18330
Target Name Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5)
Gene Name HDHD5
Gene ID 27440
Synonyms
CECR5; Haloacid dehalogenase-like hydrolase domain-containing 5; Cat eye syndrome critical region protein 5
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MATAQPSQVRQKYDTNCDAAINSHITLELYTSYLYLSMAFYFNRDDVALENFFRYFLRLS
DDKMEHAQKLMRLQNLRGGHICLHDIRKPECQGWESGLVAMESAFHLEKNVNQSLLDLYQ
LAVEKGDPQLCHFLESHYLHEQVKTIKELGGYVSNLRKICSPEAGLAEYLFDKLTLGGRV
KET
Target Bioclass
Enzyme
Family
HAD-like hydrolase superfamily
Uniprot ID
Q9BXW7
Ensemble ID
ENST00000155674.9
HGNC ID
HGNC:1843

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.T363A .
COLO679 Substitution: p.G29N .
DOTC24510 SNV: p.H130R .
EFO27 SNV: p.V85M DBIA    Probe Info 
MOLT4 Deletion: p.Q372SfsTer33 IA-alkyne    Probe Info 
NCIH358 SNV: p.G108W DBIA    Probe Info 
REC1 SNV: p.N323S DBIA    Probe Info 
SNGM SNV: p.S98N DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 25 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y129(20.00)  LDD0260  [3]
STPyne
 Probe Info  		K69(7.08)  LDD0277  [4]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
Alkylaryl probe 2
 Probe Info  		4.00  LDD0392  [5]
AHL-Pu-1
 Probe Info  		C392(3.43)  LDD0171  [6]
DBIA
 Probe Info  		C109(4.71)  LDD0209  [7]
5E-2FA
 Probe Info  		H334(0.00); H97(0.00)  LDD2235  [8]
ATP probe
 Probe Info  		K177(0.00); K69(0.00)  LDD0199  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		C109(0.00); C392(0.00); C258(0.00)  LDD0038  [10]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [11]
Lodoacetamide azide
 Probe Info  		C109(0.00); C392(0.00); C258(0.00)  LDD0037  [10]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
1d-yne
 Probe Info  		K307(0.00); K331(0.00)  LDD0356  [14]
IPM
 Probe Info  		N.A.  LDD0147  [12]
NHS
 Probe Info  		N.A.  LDD0010  [15]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [16]
1c-yne
 Probe Info  		K279(0.00); K331(0.00); K99(0.00); K307(0.00)  LDD0228  [14]
Acrolein
 Probe Info  		N.A.  LDD0217  [17]
Crotonaldehyde
 Probe Info  		H130(0.00); H334(0.00)  LDD0219  [17]
AOyne
 Probe Info  		15.00  LDD0443  [18]
NAIA_5
 Probe Info  		C109(0.00); C392(0.00); C258(0.00)  LDD2223  [13]
PAL-AfBPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		20.00  LDD0471  [19]
FFF probe13
 Probe Info  		20.00  LDD0475  [19]
FFF probe2
 Probe Info  		13.81  LDD0463  [19]
FFF probe3
 Probe Info  		12.29  LDD0464  [19]
STS-2
 Probe Info  		N.A.  LDD0139  [20]
VE-P
 Probe Info  		N.A.  LDD0396  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA DM93 C392(3.43)  LDD0171  [6]
 LDCM0214  AC1 HCT 116 C356(1.16); C362(0.83)  LDD0531  [22]
 LDCM0215  AC10 HCT 116 C356(0.62); C362(0.62)  LDD0532  [22]
 LDCM0216  AC100 HCT 116 C356(0.97); C362(0.92)  LDD0533  [22]
 LDCM0217  AC101 HCT 116 C356(0.93); C362(0.78)  LDD0534  [22]
 LDCM0218  AC102 HCT 116 C356(1.07); C362(0.85)  LDD0535  [22]
 LDCM0219  AC103 HCT 116 C356(0.76); C362(0.78)  LDD0536  [22]
 LDCM0220  AC104 HCT 116 C356(0.91); C362(0.80)  LDD0537  [22]
 LDCM0221  AC105 HCT 116 C356(0.63); C362(0.71)  LDD0538  [22]
 LDCM0222  AC106 HCT 116 C356(0.76); C362(0.64)  LDD0539  [22]
 LDCM0223  AC107 HCT 116 C356(1.01); C362(0.62)  LDD0540  [22]
 LDCM0224  AC108 HCT 116 C356(0.83); C362(0.73)  LDD0541  [22]
 LDCM0225  AC109 HCT 116 C356(0.87); C362(1.11)  LDD0542  [22]
 LDCM0226  AC11 HCT 116 C356(0.92); C362(0.80)  LDD0543  [22]
 LDCM0227  AC110 HCT 116 C356(0.72); C362(0.94)  LDD0544  [22]
 LDCM0228  AC111 HCT 116 C356(0.72); C362(0.75)  LDD0545  [22]
 LDCM0229  AC112 HCT 116 C356(0.80); C362(0.73)  LDD0546  [22]
 LDCM0230  AC113 HCT 116 C356(1.08); C362(1.00)  LDD0547  [22]
 LDCM0231  AC114 HCT 116 C356(1.06); C362(1.23)  LDD0548  [22]
 LDCM0232  AC115 HCT 116 C356(0.93); C362(1.07)  LDD0549  [22]
 LDCM0233  AC116 HCT 116 C356(0.81); C362(1.13)  LDD0550  [22]
 LDCM0234  AC117 HCT 116 C356(1.06); C362(1.08)  LDD0551  [22]
 LDCM0235  AC118 HCT 116 C356(0.99); C362(1.07)  LDD0552  [22]
 LDCM0236  AC119 HCT 116 C356(1.18); C362(1.17)  LDD0553  [22]
 LDCM0237  AC12 HCT 116 C356(0.91); C362(0.83)  LDD0554  [22]
 LDCM0238  AC120 HCT 116 C356(0.88); C362(1.00)  LDD0555  [22]
 LDCM0239  AC121 HCT 116 C356(0.98); C362(1.00)  LDD0556  [22]
 LDCM0240  AC122 HCT 116 C356(1.08); C362(0.97)  LDD0557  [22]
 LDCM0241  AC123 HCT 116 C356(1.11); C362(1.11)  LDD0558  [22]
 LDCM0242  AC124 HCT 116 C356(1.16); C362(1.30)  LDD0559  [22]
 LDCM0243  AC125 HCT 116 C356(1.23); C362(1.16)  LDD0560  [22]
 LDCM0244  AC126 HCT 116 C356(1.02); C362(0.93)  LDD0561  [22]
 LDCM0245  AC127 HCT 116 C356(1.01); C362(0.92)  LDD0562  [22]
 LDCM0246  AC128 HCT 116 C356(0.75); C362(0.75)  LDD0563  [22]
 LDCM0247  AC129 HCT 116 C356(1.00); C362(1.00)  LDD0564  [22]
 LDCM0249  AC130 HCT 116 C356(0.94); C362(0.94)  LDD0566  [22]
 LDCM0250  AC131 HCT 116 C356(0.83); C362(0.83)  LDD0567  [22]
 LDCM0251  AC132 HCT 116 C356(1.18); C362(1.18)  LDD0568  [22]
 LDCM0252  AC133 HCT 116 C356(1.03); C362(1.03)  LDD0569  [22]
 LDCM0253  AC134 HCT 116 C356(0.86); C362(0.86)  LDD0570  [22]
 LDCM0254  AC135 HCT 116 C356(0.97); C362(0.97)  LDD0571  [22]
 LDCM0255  AC136 HCT 116 C356(0.89); C362(0.89)  LDD0572  [22]
 LDCM0256  AC137 HCT 116 C356(0.93); C362(0.93)  LDD0573  [22]
 LDCM0257  AC138 HCT 116 C356(0.89); C362(0.89)  LDD0574  [22]
 LDCM0258  AC139 HCT 116 C356(1.15); C362(1.15)  LDD0575  [22]
 LDCM0259  AC14 HCT 116 C356(0.73); C362(0.69)  LDD0576  [22]
 LDCM0260  AC140 HCT 116 C356(0.96); C362(0.96)  LDD0577  [22]
 LDCM0261  AC141 HCT 116 C356(0.92); C362(0.92)  LDD0578  [22]
 LDCM0262  AC142 HCT 116 C356(1.16); C362(1.16)  LDD0579  [22]
 LDCM0263  AC143 HCT 116 C356(1.18); C362(1.18)  LDD0580  [22]
 LDCM0264  AC144 HCT 116 C356(0.65); C362(0.91)  LDD0581  [22]
 LDCM0265  AC145 HCT 116 C356(0.66); C362(0.84)  LDD0582  [22]
 LDCM0266  AC146 HCT 116 C356(0.70); C362(0.76)  LDD0583  [22]
 LDCM0267  AC147 HCT 116 C356(0.65); C362(1.05)  LDD0584  [22]
 LDCM0268  AC148 HCT 116 C356(0.84); C362(1.17)  LDD0585  [22]
 LDCM0269  AC149 HCT 116 C356(0.64); C362(0.78)  LDD0586  [22]
 LDCM0270  AC15 HCT 116 C356(0.86); C362(0.87)  LDD0587  [22]
 LDCM0271  AC150 HCT 116 C356(0.70); C362(0.76)  LDD0588  [22]
 LDCM0272  AC151 HCT 116 C362(0.71); C356(0.82)  LDD0589  [22]
 LDCM0273  AC152 HCT 116 C356(0.71); C362(0.79)  LDD0590  [22]
 LDCM0274  AC153 HCT 116 C362(0.81); C356(1.05)  LDD0591  [22]
 LDCM0621  AC154 HCT 116 C356(0.86); C362(0.74)  LDD2158  [22]
 LDCM0622  AC155 HCT 116 C356(0.84); C362(0.96)  LDD2159  [22]
 LDCM0623  AC156 HCT 116 C356(0.88); C362(0.84)  LDD2160  [22]
 LDCM0624  AC157 HCT 116 C356(0.90); C362(0.92)  LDD2161  [22]
 LDCM0276  AC17 HCT 116 C356(1.26); C362(1.30)  LDD0593  [22]
 LDCM0277  AC18 HCT 116 C362(0.84); C356(0.86)  LDD0594  [22]
 LDCM0278  AC19 HCT 116 C356(1.08); C362(1.20)  LDD0595  [22]
 LDCM0279  AC2 HCT 116 C356(0.92); C362(0.98)  LDD0596  [22]
 LDCM0280  AC20 HCT 116 C356(0.83); C362(1.05)  LDD0597  [22]
 LDCM0281  AC21 HCT 116 C362(1.00); C356(1.05)  LDD0598  [22]
 LDCM0282  AC22 HCT 116 C356(0.83); C362(1.07)  LDD0599  [22]
 LDCM0283  AC23 HCT 116 C362(1.33); C356(1.43)  LDD0600  [22]
 LDCM0284  AC24 HCT 116 C362(1.57); C356(1.80)  LDD0601  [22]
 LDCM0285  AC25 HCT 116 C362(1.01); C356(1.04)  LDD0602  [22]
 LDCM0286  AC26 HCT 116 C356(0.84); C362(0.97)  LDD0603  [22]
 LDCM0287  AC27 HCT 116 C356(0.92); C362(0.97)  LDD0604  [22]
 LDCM0288  AC28 HCT 116 C356(0.93); C362(1.00)  LDD0605  [22]
 LDCM0289  AC29 HCT 116 C356(1.07); C362(1.16)  LDD0606  [22]
 LDCM0290  AC3 HCT 116 C362(0.97); C356(1.00)  LDD0607  [22]
 LDCM0291  AC30 HCT 116 C356(1.02); C362(1.11)  LDD0608  [22]
 LDCM0292  AC31 HCT 116 C356(0.85); C362(0.91)  LDD0609  [22]
 LDCM0293  AC32 HCT 116 C356(0.86); C362(1.01)  LDD0610  [22]
 LDCM0294  AC33 HCT 116 C356(0.88); C362(1.01)  LDD0611  [22]
 LDCM0295  AC34 HCT 116 C356(0.82); C362(0.88)  LDD0612  [22]
 LDCM0296  AC35 HCT 116 C362(1.02); C356(1.03)  LDD0613  [22]
 LDCM0297  AC36 HCT 116 C362(0.94); C356(1.02)  LDD0614  [22]
 LDCM0298  AC37 HCT 116 C362(1.11); C356(1.27)  LDD0615  [22]
 LDCM0299  AC38 HCT 116 C362(1.25); C356(1.32)  LDD0616  [22]
 LDCM0300  AC39 HCT 116 C356(0.94); C362(0.98)  LDD0617  [22]
 LDCM0301  AC4 HCT 116 C362(0.82); C356(1.00)  LDD0618  [22]
 LDCM0302  AC40 HCT 116 C362(0.91); C356(0.92)  LDD0619  [22]
 LDCM0303  AC41 HCT 116 C362(1.25); C356(1.47)  LDD0620  [22]
 LDCM0304  AC42 HCT 116 C362(1.10); C356(1.18)  LDD0621  [22]
 LDCM0305  AC43 HCT 116 C362(0.99); C356(1.02)  LDD0622  [22]
 LDCM0306  AC44 HCT 116 C362(1.03); C356(1.19)  LDD0623  [22]
 LDCM0307  AC45 HCT 116 C362(0.80); C356(0.85)  LDD0624  [22]
 LDCM0308  AC46 HCT 116 C362(0.94); C356(0.96)  LDD0625  [22]
 LDCM0309  AC47 HCT 116 C362(0.83); C356(0.97)  LDD0626  [22]
 LDCM0310  AC48 HCT 116 C356(0.86); C362(0.87)  LDD0627  [22]
 LDCM0311  AC49 HCT 116 C356(0.73); C362(0.82)  LDD0628  [22]
 LDCM0312  AC5 HCT 116 C356(1.00); C362(1.04)  LDD0629  [22]
 LDCM0313  AC50 HCT 116 C356(0.76); C362(0.79)  LDD0630  [22]
 LDCM0314  AC51 HCT 116 C362(1.10); C356(1.10)  LDD0631  [22]
 LDCM0315  AC52 HCT 116 C356(0.83); C362(0.91)  LDD0632  [22]
 LDCM0316  AC53 HCT 116 C362(0.73); C356(0.75)  LDD0633  [22]
 LDCM0317  AC54 HCT 116 C362(0.89); C356(0.93)  LDD0634  [22]
 LDCM0318  AC55 HCT 116 C362(0.68); C356(0.74)  LDD0635  [22]
 LDCM0319  AC56 HCT 116 C362(0.85); C356(0.85)  LDD0636  [22]
 LDCM0320  AC57 HCT 116 C356(0.71); C362(0.86)  LDD0637  [22]
 LDCM0321  AC58 HCT 116 C356(0.68); C362(0.99)  LDD0638  [22]
 LDCM0322  AC59 HCT 116 C356(0.78); C362(0.93)  LDD0639  [22]
 LDCM0323  AC6 HCT 116 C356(0.80); C362(0.84)  LDD0640  [22]
 LDCM0324  AC60 HCT 116 C356(0.79); C362(1.01)  LDD0641  [22]
 LDCM0325  AC61 HCT 116 C356(0.65); C362(1.05)  LDD0642  [22]
 LDCM0326  AC62 HCT 116 C356(0.75); C362(1.23)  LDD0643  [22]
 LDCM0327  AC63 HCT 116 C356(0.78); C362(0.85)  LDD0644  [22]
 LDCM0328  AC64 HCT 116 C356(0.84); C362(1.01)  LDD0645  [22]
 LDCM0329  AC65 HCT 116 C356(0.73); C362(1.08)  LDD0646  [22]
 LDCM0330  AC66 HCT 116 C356(0.77); C362(1.27)  LDD0647  [22]
 LDCM0331  AC67 HCT 116 C356(0.86); C362(1.11)  LDD0648  [22]
 LDCM0332  AC68 HCT 116 C356(0.87); C362(0.91)  LDD0649  [22]
 LDCM0333  AC69 HCT 116 C362(0.76); C356(0.79)  LDD0650  [22]
 LDCM0334  AC7 HCT 116 C356(0.68); C362(0.70)  LDD0651  [22]
 LDCM0335  AC70 HCT 116 C356(0.67); C362(0.73)  LDD0652  [22]
 LDCM0336  AC71 HCT 116 C362(0.80); C356(0.85)  LDD0653  [22]
 LDCM0337  AC72 HCT 116 C356(0.88); C362(0.91)  LDD0654  [22]
 LDCM0338  AC73 HCT 116 C362(0.84); C356(0.84)  LDD0655  [22]
 LDCM0339  AC74 HCT 116 C362(0.74); C356(0.84)  LDD0656  [22]
 LDCM0340  AC75 HCT 116 C356(0.98); C362(1.00)  LDD0657  [22]
 LDCM0341  AC76 HCT 116 C362(0.67); C356(0.75)  LDD0658  [22]
 LDCM0342  AC77 HCT 116 C362(0.74); C356(0.75)  LDD0659  [22]
 LDCM0343  AC78 HCT 116 C362(0.77); C356(0.81)  LDD0660  [22]
 LDCM0344  AC79 HCT 116 C356(0.93); C362(0.95)  LDD0661  [22]
 LDCM0345  AC8 HCT 116 C356(0.76); C362(0.79)  LDD0662  [22]
 LDCM0346  AC80 HCT 116 C362(0.77); C356(0.85)  LDD0663  [22]
 LDCM0347  AC81 HCT 116 C362(0.92); C356(0.95)  LDD0664  [22]
 LDCM0348  AC82 HCT 116 C362(0.90); C356(0.93)  LDD0665  [22]
 LDCM0349  AC83 HCT 116 C356(0.58); C362(0.58)  LDD0666  [22]
 LDCM0350  AC84 HCT 116 C356(0.66); C362(0.66)  LDD0667  [22]
 LDCM0351  AC85 HCT 116 C356(0.68); C362(0.68)  LDD0668  [22]
 LDCM0352  AC86 HCT 116 C356(0.91); C362(0.91)  LDD0669  [22]
 LDCM0353  AC87 HCT 116 C356(0.93); C362(0.93)  LDD0670  [22]
 LDCM0354  AC88 HCT 116 C356(1.04); C362(1.04)  LDD0671  [22]
 LDCM0355  AC89 HCT 116 C356(0.81); C362(0.81)  LDD0672  [22]
 LDCM0357  AC90 HCT 116 C356(1.08); C362(1.08)  LDD0674  [22]
 LDCM0358  AC91 HCT 116 C356(0.57); C362(0.57)  LDD0675  [22]
 LDCM0359  AC92 HCT 116 C356(0.78); C362(0.78)  LDD0676  [22]
 LDCM0360  AC93 HCT 116 C356(1.03); C362(1.03)  LDD0677  [22]
 LDCM0361  AC94 HCT 116 C356(0.98); C362(0.98)  LDD0678  [22]
 LDCM0362  AC95 HCT 116 C356(0.69); C362(0.69)  LDD0679  [22]
 LDCM0363  AC96 HCT 116 C356(0.79); C362(0.79)  LDD0680  [22]
 LDCM0364  AC97 HCT 116 C356(0.75); C362(0.75)  LDD0681  [22]
 LDCM0365  AC98 HCT 116 C356(0.55); C362(1.01)  LDD0682  [22]
 LDCM0366  AC99 HCT 116 C362(0.86); C356(1.01)  LDD0683  [22]
 LDCM0248  AKOS034007472 HCT 116 C356(0.87); C362(0.81)  LDD0565  [22]
 LDCM0356  AKOS034007680 HCT 116 C362(0.86); C356(0.98)  LDD0673  [22]
 LDCM0275  AKOS034007705 HCT 116 C356(0.57); C362(0.58)  LDD0592  [22]
 LDCM0156  Aniline NCI-H1299 13.16  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C356(1.02); C362(1.02)  LDD2171  [22]
 LDCM0630  CCW28-3 231MFP C392(1.42)  LDD2214  [23]
 LDCM0108  Chloroacetamide HeLa C109(0.00); H334(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C109(2.00)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C362(0.85); C356(1.06)  LDD0684  [22]
 LDCM0368  CL10 HCT 116 C356(0.99); C362(1.06)  LDD0685  [22]
 LDCM0369  CL100 HCT 116 C362(0.92); C356(1.24)  LDD0686  [22]
 LDCM0370  CL101 HCT 116 C356(0.76); C362(0.76)  LDD0687  [22]
 LDCM0371  CL102 HCT 116 C362(0.80); C356(0.90)  LDD0688  [22]
 LDCM0372  CL103 HCT 116 C362(0.97); C356(1.12)  LDD0689  [22]
 LDCM0373  CL104 HCT 116 C362(0.79); C356(0.80)  LDD0690  [22]
 LDCM0374  CL105 HCT 116 C356(0.90); C362(1.06)  LDD0691  [22]
 LDCM0375  CL106 HCT 116 C356(0.81); C362(0.96)  LDD0692  [22]
 LDCM0376  CL107 HCT 116 C356(0.98); C362(1.02)  LDD0693  [22]
 LDCM0377  CL108 HCT 116 C356(1.02); C362(1.12)  LDD0694  [22]
 LDCM0378  CL109 HCT 116 C362(1.25); C356(1.25)  LDD0695  [22]
 LDCM0379  CL11 HCT 116 C356(0.77); C362(1.15)  LDD0696  [22]
 LDCM0380  CL110 HCT 116 C356(1.19); C362(1.26)  LDD0697  [22]
 LDCM0381  CL111 HCT 116 C356(1.26); C362(1.28)  LDD0698  [22]
 LDCM0382  CL112 HCT 116 C362(1.06); C356(1.13)  LDD0699  [22]
 LDCM0383  CL113 HCT 116 C356(0.85); C362(1.11)  LDD0700  [22]
 LDCM0384  CL114 HCT 116 C356(1.04); C362(1.22)  LDD0701  [22]
 LDCM0385  CL115 HCT 116 C356(1.12); C362(1.20)  LDD0702  [22]
 LDCM0386  CL116 HCT 116 C356(0.92); C362(1.04)  LDD0703  [22]
 LDCM0387  CL117 HCT 116 C356(0.96); C362(1.09)  LDD0704  [22]
 LDCM0388  CL118 HCT 116 C362(0.85); C356(0.90)  LDD0705  [22]
 LDCM0389  CL119 HCT 116 C362(0.98); C356(1.05)  LDD0706  [22]
 LDCM0390  CL12 HCT 116 C356(0.82); C362(1.40)  LDD0707  [22]
 LDCM0391  CL120 HCT 116 C362(1.03); C356(1.15)  LDD0708  [22]
 LDCM0392  CL121 HCT 116 C356(2.00); C362(2.48)  LDD0709  [22]
 LDCM0393  CL122 HCT 116 C362(0.78); C356(0.79)  LDD0710  [22]
 LDCM0394  CL123 HCT 116 C362(0.72); C356(0.79)  LDD0711  [22]
 LDCM0395  CL124 HCT 116 C362(0.74); C356(0.75)  LDD0712  [22]
 LDCM0396  CL125 HCT 116 C356(1.08); C362(1.28)  LDD0713  [22]
 LDCM0397  CL126 HCT 116 C356(0.93); C362(1.08)  LDD0714  [22]
 LDCM0398  CL127 HCT 116 C356(1.03); C362(1.19)  LDD0715  [22]
 LDCM0399  CL128 HCT 116 C356(0.91); C362(1.05)  LDD0716  [22]
 LDCM0400  CL13 HCT 116 C356(0.91); C362(1.01)  LDD0717  [22]
 LDCM0401  CL14 HCT 116 C362(0.87); C356(0.91)  LDD0718  [22]
 LDCM0402  CL15 HCT 116 C356(0.95); C362(1.09)  LDD0719  [22]
 LDCM0403  CL16 HCT 116 C356(0.73); C362(1.09)  LDD0720  [22]
 LDCM0404  CL17 HCT 116 C356(0.58); C362(0.90)  LDD0721  [22]
 LDCM0405  CL18 HCT 116 C356(0.54); C362(1.08)  LDD0722  [22]
 LDCM0406  CL19 HCT 116 C356(0.65); C362(1.11)  LDD0723  [22]
 LDCM0407  CL2 HCT 116 C362(0.80); C356(0.98)  LDD0724  [22]
 LDCM0408  CL20 HCT 116 C356(0.66); C362(1.28)  LDD0725  [22]
 LDCM0409  CL21 HCT 116 C356(0.54); C362(1.19)  LDD0726  [22]
 LDCM0410  CL22 HCT 116 C356(0.70); C362(1.99)  LDD0727  [22]
 LDCM0411  CL23 HCT 116 C356(0.74); C362(1.06)  LDD0728  [22]
 LDCM0412  CL24 HCT 116 C356(0.50); C362(1.40)  LDD0729  [22]
 LDCM0413  CL25 HCT 116 C356(0.67); C362(1.29)  LDD0730  [22]
 LDCM0414  CL26 HCT 116 C356(0.72); C362(1.00)  LDD0731  [22]
 LDCM0415  CL27 HCT 116 C356(0.69); C362(0.91)  LDD0732  [22]
 LDCM0416  CL28 HCT 116 C356(0.61); C362(1.02)  LDD0733  [22]
 LDCM0417  CL29 HCT 116 C356(0.65); C362(1.08)  LDD0734  [22]
 LDCM0418  CL3 HCT 116 C356(0.87); C362(0.92)  LDD0735  [22]
 LDCM0419  CL30 HCT 116 C356(0.64); C362(0.86)  LDD0736  [22]
 LDCM0420  CL31 HCT 116 C356(1.38); C362(1.06)  LDD0737  [22]
 LDCM0421  CL32 HCT 116 C356(0.80); C362(1.10)  LDD0738  [22]
 LDCM0422  CL33 HCT 116 C356(0.82); C362(1.26)  LDD0739  [22]
 LDCM0423  CL34 HCT 116 C356(0.84); C362(1.53)  LDD0740  [22]
 LDCM0424  CL35 HCT 116 C356(0.94); C362(1.67)  LDD0741  [22]
 LDCM0425  CL36 HCT 116 C356(1.01); C362(1.38)  LDD0742  [22]
 LDCM0426  CL37 HCT 116 C356(1.04); C362(1.65)  LDD0743  [22]
 LDCM0428  CL39 HCT 116 C356(1.06); C362(1.52)  LDD0745  [22]
 LDCM0429  CL4 HCT 116 C356(0.95); C362(1.03)  LDD0746  [22]
 LDCM0430  CL40 HCT 116 C356(1.06); C362(1.64)  LDD0747  [22]
 LDCM0431  CL41 HCT 116 C356(1.06); C362(1.34)  LDD0748  [22]
 LDCM0432  CL42 HCT 116 C356(1.16); C362(1.63)  LDD0749  [22]
 LDCM0433  CL43 HCT 116 C356(1.24); C362(1.96)  LDD0750  [22]
 LDCM0434  CL44 HCT 116 C356(1.21); C362(1.32)  LDD0751  [22]
 LDCM0435  CL45 HCT 116 C356(0.90); C362(1.30)  LDD0752  [22]
 LDCM0436  CL46 HCT 116 C356(1.02); C362(1.30)  LDD0753  [22]
 LDCM0437  CL47 HCT 116 C356(1.00); C362(1.09)  LDD0754  [22]
 LDCM0438  CL48 HCT 116 C356(0.96); C362(1.01)  LDD0755  [22]
 LDCM0439  CL49 HCT 116 C356(0.92); C362(1.02)  LDD0756  [22]
 LDCM0440  CL5 HCT 116 C356(1.12); C362(1.00)  LDD0757  [22]
 LDCM0441  CL50 HCT 116 C356(1.02); C362(0.99)  LDD0758  [22]
 LDCM0442  CL51 HCT 116 C356(1.10); C362(1.12)  LDD0759  [22]
 LDCM0443  CL52 HCT 116 C356(1.24); C362(1.18)  LDD0760  [22]
 LDCM0444  CL53 HCT 116 C356(1.26); C362(1.19)  LDD0761  [22]
 LDCM0445  CL54 HCT 116 C356(1.21); C362(1.09)  LDD0762  [22]
 LDCM0446  CL55 HCT 116 C356(1.50); C362(1.19)  LDD0763  [22]
 LDCM0447  CL56 HCT 116 C356(1.21); C362(1.06)  LDD0764  [22]
 LDCM0448  CL57 HCT 116 C356(1.36); C362(1.24)  LDD0765  [22]
 LDCM0449  CL58 HCT 116 C356(1.48); C362(1.27)  LDD0766  [22]
 LDCM0450  CL59 HCT 116 C356(1.33); C362(1.05)  LDD0767  [22]
 LDCM0451  CL6 HCT 116 C356(0.86); C362(0.99)  LDD0768  [22]
 LDCM0452  CL60 HCT 116 C356(1.30); C362(1.10)  LDD0769  [22]
 LDCM0453  CL61 HCT 116 C356(1.06); C362(0.91)  LDD0770  [22]
 LDCM0454  CL62 HCT 116 C356(1.04); C362(0.88)  LDD0771  [22]
 LDCM0455  CL63 HCT 116 C356(0.92); C362(0.84)  LDD0772  [22]
 LDCM0456  CL64 HCT 116 C356(1.10); C362(0.95)  LDD0773  [22]
 LDCM0457  CL65 HCT 116 C356(1.15); C362(0.95)  LDD0774  [22]
 LDCM0458  CL66 HCT 116 C356(0.81); C362(0.76)  LDD0775  [22]
 LDCM0459  CL67 HCT 116 C356(0.96); C362(0.91)  LDD0776  [22]
 LDCM0460  CL68 HCT 116 C356(0.77); C362(0.72)  LDD0777  [22]
 LDCM0461  CL69 HCT 116 C356(0.84); C362(0.80)  LDD0778  [22]
 LDCM0462  CL7 HCT 116 C356(0.69); C362(0.99)  LDD0779  [22]
 LDCM0463  CL70 HCT 116 C356(0.88); C362(0.81)  LDD0780  [22]
 LDCM0464  CL71 HCT 116 C356(0.85); C362(0.82)  LDD0781  [22]
 LDCM0465  CL72 HCT 116 C356(1.12); C362(1.00)  LDD0782  [22]
 LDCM0466  CL73 HCT 116 C356(0.95); C362(0.89)  LDD0783  [22]
 LDCM0467  CL74 HCT 116 C356(0.92); C362(0.82)  LDD0784  [22]
 LDCM0469  CL76 HCT 116 C356(0.82); C362(1.07)  LDD0786  [22]
 LDCM0470  CL77 HCT 116 C356(1.11); C362(1.23)  LDD0787  [22]
 LDCM0471  CL78 HCT 116 C356(1.01); C362(0.98)  LDD0788  [22]
 LDCM0472  CL79 HCT 116 C356(0.90); C362(1.18)  LDD0789  [22]
 LDCM0473  CL8 HCT 116 C356(0.79); C362(1.27)  LDD0790  [22]
 LDCM0474  CL80 HCT 116 C356(0.95); C362(1.29)  LDD0791  [22]
 LDCM0475  CL81 HCT 116 C356(0.93); C362(1.09)  LDD0792  [22]
 LDCM0476  CL82 HCT 116 C356(0.98); C362(1.36)  LDD0793  [22]
 LDCM0477  CL83 HCT 116 C356(1.00); C362(1.40)  LDD0794  [22]
 LDCM0478  CL84 HCT 116 C356(0.90); C362(1.20)  LDD0795  [22]
 LDCM0479  CL85 HCT 116 C356(0.99); C362(1.03)  LDD0796  [22]
 LDCM0480  CL86 HCT 116 C356(1.02); C362(1.32)  LDD0797  [22]
 LDCM0481  CL87 HCT 116 C356(1.16); C362(1.11)  LDD0798  [22]
 LDCM0482  CL88 HCT 116 C356(0.91); C362(1.44)  LDD0799  [22]
 LDCM0483  CL89 HCT 116 C356(1.13); C362(1.57)  LDD0800  [22]
 LDCM0484  CL9 HCT 116 C356(0.83); C362(0.92)  LDD0801  [22]
 LDCM0485  CL90 HCT 116 C356(1.13); C362(1.64)  LDD0802  [22]
 LDCM0486  CL91 HCT 116 C356(1.02); C362(1.10)  LDD0803  [22]
 LDCM0487  CL92 HCT 116 C356(0.88); C362(1.04)  LDD0804  [22]
 LDCM0488  CL93 HCT 116 C356(0.94); C362(0.83)  LDD0805  [22]
 LDCM0489  CL94 HCT 116 C356(1.10); C362(0.98)  LDD0806  [22]
 LDCM0490  CL95 HCT 116 C356(1.07); C362(1.06)  LDD0807  [22]
 LDCM0491  CL96 HCT 116 C356(1.00); C362(1.14)  LDD0808  [22]
 LDCM0492  CL97 HCT 116 C356(0.77); C362(1.06)  LDD0809  [22]
 LDCM0493  CL98 HCT 116 C356(1.12); C362(0.91)  LDD0810  [22]
 LDCM0494  CL99 HCT 116 C356(1.05); C362(0.98)  LDD0811  [22]
 LDCM0495  E2913 HEK-293T C258(0.95); C109(0.85); C392(0.92); C362(1.08)  LDD1698  [24]
 LDCM0572  Fragment10 MDA-MB-231 C392(20.00)  LDD1465  [25]
 LDCM0573  Fragment11 MDA-MB-231 C392(1.11)  LDD1467  [25]
 LDCM0574  Fragment12 MDA-MB-231 C392(5.13)  LDD1468  [25]
 LDCM0575  Fragment13 MDA-MB-231 C392(2.04)  LDD1469  [25]
 LDCM0576  Fragment14 MDA-MB-231 C392(1.63)  LDD1471  [25]
 LDCM0580  Fragment21 MDA-MB-231 C392(1.64)  LDD1473  [25]
 LDCM0578  Fragment27 MDA-MB-231 C392(1.33)  LDD1474  [25]
 LDCM0586  Fragment28 MDA-MB-231 C392(1.00)  LDD1475  [25]
 LDCM0587  Fragment29 Ramos C392(1.47)  LDD1476  [25]
 LDCM0468  Fragment33 HCT 116 C356(0.93); C362(0.89)  LDD0785  [22]
 LDCM0596  Fragment38 MDA-MB-231 C392(0.76)  LDD1480  [25]
 LDCM0566  Fragment4 MDA-MB-231 C392(2.22)  LDD1461  [25]
 LDCM0599  Fragment41 MDA-MB-231 C392(0.96)  LDD1481  [25]
 LDCM0603  Fragment45 MDA-MB-231 C392(4.93)  LDD1482  [25]
 LDCM0427  Fragment51 HCT 116 C356(0.95); C362(2.75)  LDD0744  [22]
 LDCM0614  Fragment56 MDA-MB-231 C392(0.82)  LDD1484  [25]
 LDCM0569  Fragment7 Ramos C392(0.63)  LDD2186  [26]
 LDCM0570  Fragment8 MDA-MB-231 C392(3.16)  LDD1462  [25]
 LDCM0571  Fragment9 MDA-MB-231 C392(1.47)  LDD1463  [25]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 MDA-MB-231 C392(3.57)  LDD1460  [25]
 LDCM0023  KB03 Jurkat C109(4.71)  LDD0209  [7]
 LDCM0024  KB05 RVH421 C79(2.85)  LDD3320  [27]
 LDCM0109  NEM HeLa H97(0.00); H334(0.00); H388(0.00); H386(0.00)  LDD0223  [17]
 LDCM0628  OTUB2-COV-1 HEK-293T C258(2.02)  LDD2207  [28]
 LDCM0099  Phenelzine MDA-MB-231 4.00  LDD0392  [5]
 LDCM0021  THZ1 HCT 116 C356(1.02); C362(1.02)  LDD2173  [22]

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Hydrazines as versatile chemical biology probes and drug-discovery tools for cofactor-dependent enzymes. bioRxiv, 2020-06.
6 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
7 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
8 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
9 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
15 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
16 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
19 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
20 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
21 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
22 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
23 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
24 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
25 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
26 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
27 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
28 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.