Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment8  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 65 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 20.0
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 20.0
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 20.0
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 20.0
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) C267 20.0
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 20.0
 LDTP13980  Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) C105 20.0
 LDTP09598  Mitochondrial coenzyme A diphosphatase NUDT8 (NUDT8) C207 20.0
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 20.0
 LDTP03401  Multifunctional protein CAD (CAD) C73 20.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 20.0
 LDTP09126  Probable aminopeptidase NPEPL1 (NPEPL1) C81 20.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 20.0
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C57 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C71 20.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C307 20.0
 LDTP19669  Threonine synthase-like 1 (THNSL1) C324 20.0
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 20.0
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 20.0
 LDTP06320  [Pyruvate dehydrogenase (acetyl-transferring)] kinase isozyme 1, mitochondrial (PDK1) C71 20.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 15.2
 LDTP03000  General transcription and DNA repair factor IIH helicase subunit XPB (ERCC3) C342 12.4
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 6.8
 LDTP05289  AMP deaminase 2 (AMPD2) C107 6.2
 LDTP02502  Thioredoxin (TXN) C32 5.9
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 5.5
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C190 5.2
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 5.0
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 4.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 4.5
 LDTP03152  Protein-L-isoaspartate(D-aspartate) O-methyltransferase (PCMT1) C102 4.5
 LDTP10973  Thioredoxin, mitochondrial (TXN2) C90 4.5
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 4.4
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 3.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 3.7
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 3.5
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 3.2
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 2.7
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 2.6
 LDTP03770  Alpha-adducin (ADD1) C68 2.4
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 2.4
 LDTP02022  Thymidine kinase, cytosolic (TK1) C66 2.3
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 2.0
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 1.7
 LDTP04262  Alanine--tRNA ligase, cytoplasmic (AARS1) C773 1.5
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 1.4
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.4
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 1.2
 LDTP10785  Ubiquitin carboxyl-terminal hydrolase 28 (USP28) C171 1.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 0.9
 LDTP05075  Tubulin alpha-4A chain (TUBA4A) C54 0.9
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.8
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.8
 LDTP02329  3-ketoacyl-CoA thiolase, peroxisomal (ACAA1) C381 0.8
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 0.7
 LDTP03258  Thymidylate kinase (DTYMK) C163 0.6
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C312 0.5
 LDTP03258  Thymidylate kinase (DTYMK) C117 0.4
Transporter and channel
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 20.0
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 10.3
 LDTP04801  Gasdermin-D (GSDMD) C268 8.4
 LDTP13824  Voltage-dependent anion-selective channel protein 3 (VDAC3) C65 6.2
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 5.1
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 4.7
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 2.0
Transcription factor
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03280  COUP transcription factor 2 (NR2F2) C326 20.0
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 12.0
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 7.4
Other
Click to Show/Hide to Show 48 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 20.0
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 20.0
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C391 20.0
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 20.0
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 20.0
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 20.0
 LDTP05867  Treacle protein (TCOF1) C1298 20.0
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 20.0
 LDTP12443  Anillin (ANLN) C712 14.1
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 9.6
 LDTP11235  Protein PAXX (PAXX) C180 6.6
 LDTP12571  LanC-like protein 2 (LANCL2) C187 6.1
 LDTP06276  MAD2L1-binding protein (MAD2L1BP) C124 5.4
 LDTP04594  Protein transport protein Sec24C (SEC24C) C78 5.4
 LDTP10613  Dedicator of cytokinesis protein 7 (DOCK7) C2125 5.4
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 5.3
 LDTP17765  Protein KRI1 homolog (KRI1) C673 5.3
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 5.1
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 4.9
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 4.6
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 4.6
 LDTP13580  Coronin-1C (CORO1C) C420 4.6
 LDTP15896  Ashwin (C2orf49) C10 4.5
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 4.4
 LDTP01299  WD repeat and HMG-box DNA-binding protein 1 (WDHD1) C773 4.2
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 4.2
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 4.1
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 3.6
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 3.2
 LDTP01532  ZW10 interactor (ZWINT) C54 3.1
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 2.7
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 2.7
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 2.4
 LDTP12144  GrpE protein homolog 1, mitochondrial (GRPEL1) C124 2.2
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 2.1
 LDTP05867  Treacle protein (TCOF1) C38 2.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C629 1.7
 LDTP10843  MMS19 nucleotide excision repair protein homolog (MMS19) C848 1.7
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.6
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.5
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 1.4
 LDTP10864  Calponin-2 (CNN2) C164 1.1
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.0
 LDTP14215  Small ribosomal subunit protein mS40 (MRPS18B) C128 1.0
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.9
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.8
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 0.6
 LDTP04560  Cytosolic Fe-S cluster assembly factor NUBP1 (NUBP1) C235 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.