Details of the Target

General Information of Target

Target ID LDTP14217
Target Name Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1)
Gene Name AUP1
Gene ID 550
Synonyms
Lipid droplet-regulating VLDL assembly factor AUP1; Ancient ubiquitous protein 1
3D Structure
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2D Sequence (FASTA)
Download
3D Structure (PDB)
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Sequence
MLKKFDKKDEESGGGSNPFQHLEKSAVLQEARVFNETPINPRKCAHILTKILYLINQGEH
LGTTEATEAFFAMTKLFQSNDPTLRRMCYLTIKEMSCIAEDVIIVTSSLTKDMTGKEDNY
RGPAVRALCQITDSTMLQAIERYMKQAIVDKVPSVSSSALVSSLHLLKCSFDVVKRWVNE
AQEAASSDNIMVQYHALGLLYHVRKNDRLAVNKMISKVTRHGLKSPFAYCMMIRVASKQL
EEEDGSRDSPLFDFIESCLRNKHEMVVYEAASAIVNLPGCSAKELAPAVSVLQLFCSSPK
AALRYAAVRTLNKVAMKHPSAVTACNLDLENLVTDSNRSIATLAITTLLKTGSESSIDRL
MKQISSFMSEISDEFKVVVVQAISALCQKYPRKHAVLMNFLFTMLREEGGFEYKRAIVDC
IISIIEENSESKETGLSHLCEFIEDCEFTVLATRILHLLGQEGPKTTNPSKYIRFIYNRV
VLEHEEVRAGAVSALAKFGAQNEEMLPSILVLLKRCVMDDDNEVRDRATFYLNVLEQKQK
ALNAGYILNGLTVSIPGLERALQQYTLEPSEKPFDLKSVPLATAPMAEQRTESTPITAVK
QPEKVAATRQEIFQEQLAAVPEFRGLGPLFKSSPEPVALTESETEYVIRCTKHTFTNHMV
FQFDCTNTLNDQTLENVTVQMEPTEAYEVLCYVPARSLPYNQPGTCYTLVALPKEDPTAV
ACTFSCMMKFTVKDCDPTTGETDDEGYEDEYVLEDLEVTVADHIQKVMKLNFEAAWDEVG
DEFEKEETFTLSTIKTLEEAVGNIVKFLGMHPCERSDKVPDNKNTHTLLLAGVFRGGHDI
LVRSRLLLLDTVTMQVTARSLEELPVDIILASVG
Target Bioclass
Other
Family
AUP1 family
Subcellular location
Cytoplasmic vesicle, autophagosome; Endoplasmic reticulum membrane
Function
Plays a role in the translocation of terminally misfolded proteins from the endoplasmic reticulum lumen to the cytoplasm and their degradation by the proteasome. Plays a role in lipid droplet formation. Induces lipid droplet clustering. Recruits ubiquitin-conjugating enzyme UBE2G2 to lipid droplets which facilitates its interaction with ubiquitin ligases AMFR/gp78 and RNF139/TRC8, leading to sterol-induced ubiquitination of HMGCR and its subsequent proteasomal degradation. Also required for the degradation of INSIG1, SREBF1 and SREBF2. Plays a role in regulating assembly and secretion of very low density lipoprotein particles and stability of apolipoprotein APOB.; (Microbial infection) Following Dengue virus infection, required for induction of lipophagy which facilitates production of virus progeny particles.
Uniprot ID
Q9Y679
Ensemble ID
ENST00000377526.4
HGNC ID
HGNC:891

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 19 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
HDSF-alk
 Probe Info  		3.17  LDD0197  [2]
DA-P2
 Probe Info  		6.25  LDD0348  [3]
HRP
 Probe Info  		5.48  LDD0347  [3]
STPyne
 Probe Info  		K143(6.75); K250(6.46); K264(9.33); K305(10.00)  LDD0277  [4]
BTD
 Probe Info  		C146(3.36)  LDD1699  [5]
ONAyne
 Probe Info  		K143(10.00)  LDD0275  [4]
DA-P3
 Probe Info  		5.93  LDD0179  [3]
EA-probe
 Probe Info  		N.A.  LDD0440  [6]
Acrolein
 Probe Info  		N.A.  LDD0222  [7]
DBIA
 Probe Info  		C70(1.72)  LDD0531  [8]
5E-2FA
 Probe Info  		N.A.  LDD2235  [9]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [10]
IA-alkyne
 Probe Info  		C70(0.00); C146(0.00); C111(0.00)  LDD0162  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
IPM
 Probe Info  		N.A.  LDD0005  [13]
TFBX
 Probe Info  		C70(0.00); C146(0.00)  LDD0148  [14]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [15]
AOyne
 Probe Info  		15.00  LDD0443  [16]
PAL-AfBPP Probe
Click To Hide/Show 14 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C161
 Probe Info  		9.99  LDD1841  [17]
C196
 Probe Info  		13.64  LDD1872  [17]
C266
 Probe Info  		8.88  LDD1937  [17]
C284
 Probe Info  		24.08  LDD1954  [17]
C288
 Probe Info  		6.63  LDD1958  [17]
C305
 Probe Info  		14.32  LDD1974  [17]
FFF probe11
 Probe Info  		20.00  LDD0471  [18]
FFF probe14
 Probe Info  		20.00  LDD0477  [18]
FFF probe15
 Probe Info  		7.84  LDD0478  [18]
FFF probe2
 Probe Info  		20.00  LDD0463  [18]
FFF probe3
 Probe Info  		18.40  LDD0464  [18]
VE-P
 Probe Info  		N.A.  LDD0396  [19]
A-DA
 Probe Info  		2.76  LDD0143  [20]
Probe 8
 Probe Info  		3.11  LDD0442  [21]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C146(0.52)  LDD2095  [5]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C146(0.65)  LDD2130  [5]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C146(0.69)  LDD2117  [5]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C146(1.42)  LDD2152  [5]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C146(0.39)  LDD2132  [5]
 LDCM0214  AC1 HCT 116 C70(1.72)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C70(1.32)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C70(0.66)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C70(0.69)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C70(0.72)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C70(0.69)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C70(0.60)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C70(0.74)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C70(0.65)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C70(0.83)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C70(0.53)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C70(0.70)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C70(1.27)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C70(0.76)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C70(0.70)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C70(0.73)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C70(0.97)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C70(0.97)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C70(0.92)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C70(0.85)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C70(0.98)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C70(1.11)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C70(0.88)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C70(0.97)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C70(0.88)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C70(1.01)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C70(1.08)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C70(0.98)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C70(0.89)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C70(1.09)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C70(1.13)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C70(0.99)  LDD0562  [8]
 LDCM0246  AC128 PaTu 8988t C70(1.19)  LDD1125  [8]
 LDCM0247  AC129 PaTu 8988t C70(1.02)  LDD1126  [8]
 LDCM0249  AC130 PaTu 8988t C70(0.99)  LDD1128  [8]
 LDCM0250  AC131 PaTu 8988t C70(0.99)  LDD1129  [8]
 LDCM0251  AC132 PaTu 8988t C70(0.96)  LDD1130  [8]
 LDCM0252  AC133 PaTu 8988t C70(0.98)  LDD1131  [8]
 LDCM0253  AC134 PaTu 8988t C70(1.02)  LDD1132  [8]
 LDCM0254  AC135 PaTu 8988t C70(1.01)  LDD1133  [8]
 LDCM0255  AC136 PaTu 8988t C70(1.15)  LDD1134  [8]
 LDCM0256  AC137 PaTu 8988t C70(1.04)  LDD1135  [8]
 LDCM0257  AC138 PaTu 8988t C70(0.95)  LDD1136  [8]
 LDCM0258  AC139 PaTu 8988t C70(0.97)  LDD1137  [8]
 LDCM0259  AC14 HCT 116 C70(0.95)  LDD0576  [8]
 LDCM0260  AC140 PaTu 8988t C70(1.13)  LDD1139  [8]
 LDCM0261  AC141 PaTu 8988t C70(1.00)  LDD1140  [8]
 LDCM0262  AC142 PaTu 8988t C70(0.92)  LDD1141  [8]
 LDCM0263  AC143 HCT 116 C70(0.92)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C70(0.76)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C70(1.06)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C70(1.04)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C70(0.65)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C70(0.81)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C70(0.75)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C70(1.11)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C70(1.02)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C70(1.00)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C70(0.65)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C70(0.77)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C70(0.92)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C70(0.80)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C70(0.97)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C70(0.84)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C70(0.96)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C70(0.74)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C70(0.88)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C70(1.49)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C70(0.92)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C70(0.86)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C70(0.92)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C70(0.93)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C70(0.99)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C70(0.92)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C70(0.93)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C70(0.86)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C70(0.80)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C70(0.89)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C70(1.99)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C70(0.86)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C70(0.96)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C70(0.83)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C70(0.72)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C70(0.75)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C70(1.06)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C70(1.17)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C70(1.51)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C70(1.14)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C70(1.01)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C70(1.79)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C70(1.08)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C70(1.16)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C70(1.24)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C70(1.09)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C70(1.06)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C70(1.04)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C70(1.02)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C70(0.92)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C70(0.98)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C70(0.97)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C70(1.86)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C70(0.90)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C70(0.91)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C70(1.00)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C70(0.91)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C70(1.03)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C70(0.87)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C70(1.01)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C70(0.80)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C70(0.70)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C70(0.76)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C70(0.76)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C70(0.67)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C70(0.82)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C70(0.78)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C70(0.92)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C70(0.85)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C70(1.03)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C70(1.04)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C70(0.91)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C70(0.87)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C70(0.98)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C70(0.95)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C70(0.86)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C70(1.03)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C70(0.88)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C70(1.00)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C70(1.17)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C70(1.04)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C70(0.89)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C70(1.09)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C70(0.88)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C70(1.09)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C70(1.08)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C70(1.32)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C70(0.93)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C70(1.24)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C70(1.06)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C70(0.98)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C70(0.91)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C70(1.04)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C70(1.39)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C70(1.01)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C70(0.89)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C70(1.78)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C70(0.95)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C70(0.86)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C70(1.09)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C70(0.75)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C70(1.44)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C70(1.04)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C70(1.00)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C70(0.70)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C70(0.78)  LDD0683  [8]
 LDCM0520  AKOS000195272 MDA-MB-231 C146(0.95)  LDD2113  [5]
 LDCM0248  AKOS034007472 HCT 116 C70(1.21)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C70(1.06)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C70(1.12)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 12.80  LDD0403  [1]
 LDCM0083  Avasimibe A-549 2.76  LDD0143  [20]
 LDCM0498  BS-3668 MDA-MB-231 C146(0.85)  LDD2091  [5]
 LDCM0630  CCW28-3 231MFP C325(0.98)  LDD2214  [22]
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0367  CL1 HCT 116 C70(1.16)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C70(0.93)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C70(1.52)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C70(0.97)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C70(1.19)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C70(1.25)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C70(1.10)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C70(0.87)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C70(0.75)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C70(0.83)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C70(0.81)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C70(0.83)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C70(0.78)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C70(0.78)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C70(0.81)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C70(1.11)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C70(0.77)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C70(0.88)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C70(0.91)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C70(0.93)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C70(1.17)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C70(1.07)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C70(1.09)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C70(0.93)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C70(1.12)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C70(0.98)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C70(0.86)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C70(0.96)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C70(0.95)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C70(1.11)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C70(0.80)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C70(0.68)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C70(0.71)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C70(0.90)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C70(0.85)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C70(0.98)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C70(1.00)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C70(1.11)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C70(0.87)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C70(1.16)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C70(1.08)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C70(0.93)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C70(0.98)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C70(1.10)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C70(0.88)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C70(0.93)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C70(0.93)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C70(1.02)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C70(0.97)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C70(0.94)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C70(1.14)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C70(0.95)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C70(1.04)  LDD0736  [8]
 LDCM0420  CL31 HEK-293T C70(0.89)  LDD1018  [8]
 LDCM0421  CL32 HEK-293T C70(1.11)  LDD1019  [8]
 LDCM0422  CL33 HEK-293T C70(0.98)  LDD1020  [8]
 LDCM0423  CL34 HEK-293T C70(0.94)  LDD1021  [8]
 LDCM0424  CL35 HEK-293T C70(1.10)  LDD1022  [8]
 LDCM0425  CL36 HEK-293T C70(0.96)  LDD1023  [8]
 LDCM0426  CL37 HEK-293T C70(1.23)  LDD1024  [8]
 LDCM0428  CL39 HEK-293T C70(1.06)  LDD1026  [8]
 LDCM0429  CL4 HCT 116 C70(1.11)  LDD0746  [8]
 LDCM0430  CL40 HEK-293T C70(0.84)  LDD1028  [8]
 LDCM0431  CL41 HEK-293T C70(0.87)  LDD1029  [8]
 LDCM0432  CL42 HEK-293T C70(1.12)  LDD1030  [8]
 LDCM0433  CL43 HEK-293T C70(1.10)  LDD1031  [8]
 LDCM0434  CL44 HEK-293T C70(0.94)  LDD1032  [8]
 LDCM0435  CL45 HEK-293T C70(1.02)  LDD1033  [8]
 LDCM0436  CL46 HCT 116 C70(1.55)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C70(1.07)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C70(1.15)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C70(1.58)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C70(1.05)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C70(1.16)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C70(1.36)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C70(1.43)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C70(0.85)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C70(1.21)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C70(1.15)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C70(1.03)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C70(1.22)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C70(1.56)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C70(1.33)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C70(0.92)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C70(1.19)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C70(0.95)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C70(0.84)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C70(0.87)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C70(0.77)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C70(0.82)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C70(0.73)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C70(0.76)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C70(0.81)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C70(0.88)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C70(0.92)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C70(0.89)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C70(0.75)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C70(0.97)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C70(0.82)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C70(0.76)  LDD0784  [8]
 LDCM0469  CL76 PaTu 8988t C70(0.85)  LDD1348  [8]
 LDCM0470  CL77 PaTu 8988t C70(0.80)  LDD1349  [8]
 LDCM0471  CL78 PaTu 8988t C70(0.53)  LDD1350  [8]
 LDCM0472  CL79 PaTu 8988t C70(0.65)  LDD1351  [8]
 LDCM0473  CL8 HCT 116 C70(0.80)  LDD0790  [8]
 LDCM0474  CL80 PaTu 8988t C70(0.58)  LDD1353  [8]
 LDCM0475  CL81 PaTu 8988t C70(0.55)  LDD1354  [8]
 LDCM0476  CL82 PaTu 8988t C70(0.67)  LDD1355  [8]
 LDCM0477  CL83 PaTu 8988t C70(0.68)  LDD1356  [8]
 LDCM0478  CL84 PaTu 8988t C70(0.84)  LDD1357  [8]
 LDCM0479  CL85 PaTu 8988t C70(0.66)  LDD1358  [8]
 LDCM0480  CL86 PaTu 8988t C70(0.58)  LDD1359  [8]
 LDCM0481  CL87 PaTu 8988t C70(0.63)  LDD1360  [8]
 LDCM0482  CL88 PaTu 8988t C70(0.57)  LDD1361  [8]
 LDCM0483  CL89 PaTu 8988t C70(0.86)  LDD1362  [8]
 LDCM0484  CL9 HCT 116 C70(0.92)  LDD0801  [8]
 LDCM0485  CL90 PaTu 8988t C70(0.56)  LDD1364  [8]
 LDCM0486  CL91 HCT 116 C70(1.14)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C70(0.84)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C70(0.90)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C70(0.66)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C70(0.82)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C70(1.03)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C70(1.30)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C70(1.85)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C70(1.92)  LDD0811  [8]
 LDCM0177  Compound 4 SW480 3.11  LDD0442  [21]
 LDCM0028  Dobutamine HEK-293T 5.28  LDD0180  [3]
 LDCM0027  Dopamine HEK-293T 5.93  LDD0179  [3]
 LDCM0495  E2913 HEK-293T C70(0.93); C325(1.41)  LDD1698  [23]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C146(10.43)  LDD1702  [5]
 LDCM0031  Epigallocatechin gallate HEK-293T 5.77  LDD0183  [3]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [6]
 LDCM0625  F8 Ramos C70(0.48)  LDD2187  [24]
 LDCM0573  Fragment11 MDA-MB-231 C391(3.03)  LDD1467  [25]
 LDCM0576  Fragment14 Ramos C70(2.72)  LDD2193  [24]
 LDCM0580  Fragment21 MDA-MB-231 C391(1.54)  LDD1473  [25]
 LDCM0578  Fragment27 MDA-MB-231 C391(1.19)  LDD1474  [25]
 LDCM0586  Fragment28 Ramos C70(1.57)  LDD2198  [24]
 LDCM0468  Fragment33 HCT 116 C70(0.75)  LDD0785  [8]
 LDCM0566  Fragment4 MDA-MB-231 C391(20.00)  LDD1461  [25]
 LDCM0603  Fragment45 MDA-MB-231 C391(20.00)  LDD1482  [25]
 LDCM0427  Fragment51 HEK-293T C70(1.03)  LDD1025  [8]
 LDCM0614  Fragment56 MDA-MB-231 C391(0.74)  LDD1484  [25]
 LDCM0569  Fragment7 Ramos C70(0.82)  LDD2186  [24]
 LDCM0570  Fragment8 MDA-MB-231 C391(20.00)  LDD1462  [25]
 LDCM0022  KB02 HEK-293T C70(0.89); C325(0.75); C111(0.90)  LDD1492  [23]
 LDCM0023  KB03 HEK-293T C70(0.96); C325(0.84); C111(0.90)  LDD1497  [23]
 LDCM0024  KB05 HMCB C325(2.26)  LDD3312  [26]
 LDCM0030  Luteolin HEK-293T 10.62  LDD0182  [3]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C146(0.97)  LDD2121  [5]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C146(1.10)  LDD2089  [5]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C146(0.58)  LDD2098  [5]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C146(0.92)  LDD2105  [5]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C146(0.98)  LDD2107  [5]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C146(1.01)  LDD2111  [5]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C146(0.84)  LDD2120  [5]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C146(1.00); C70(1.11)  LDD2123  [5]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C146(0.69)  LDD2125  [5]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C146(0.96)  LDD2127  [5]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C146(0.97)  LDD2129  [5]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C146(1.00)  LDD2135  [5]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C146(1.16)  LDD2136  [5]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C146(0.47)  LDD2137  [5]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C146(0.94)  LDD2140  [5]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C146(1.47)  LDD2144  [5]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C146(1.05)  LDD2150  [5]
 LDCM0628  OTUB2-COV-1 HEK-293T C70(0.53)  LDD2207  [27]
 LDCM0029  Quercetin HEK-293T 10.12  LDD0181  [3]
 LDCM0084  Ro 48-8071 A-549 2.31  LDD0145  [20]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ubiquitin-conjugating enzyme E2 G2 (UBE2G2) Ubiquitin-conjugating enzyme family P60604
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Mu-type opioid receptor (OPRM1) G-protein coupled receptor 1 family P35372

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Fatty Acyl Sulfonyl Fluoride as an Activity-Based Probe for Profiling Fatty Acid-Associated Proteins in Living Cells. Chembiochem. 2022 Feb 16;23(4):e202100628. doi: 10.1002/cbic.202100628. Epub 2021 Dec 30.
3 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
6 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
10 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
11 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
17 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
18 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
19 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
20 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
21 Target Deconvolution Efforts on Wnt Pathway Screen Reveal Dual Modulation of Oxidative Phosphorylation and SERCA2. ChemMedChem. 2017 Jun 21;12(12):917-924. doi: 10.1002/cmdc.201700028. Epub 2017 Apr 26.
22 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
23 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
24 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
25 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
26 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
27 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.