Details of the Target

General Information of Target

Target ID LDTP10642
Target Name Chloride intracellular channel protein 6 (CLIC6)
Gene Name CLIC6
Gene ID 54102
Synonyms
CLIC1L; Chloride intracellular channel protein 6; Parchorin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGRKEEDDCSSWKKQTTNIRKTFIFMEVLGSGAFSEVFLVKQRLTGKLFALKCIKKSPAF
RDSSLENEIAVLKKIKHENIVTLEDIYESTTHYYLVMQLVSGGELFDRILERGVYTEKDA
SLVIQQVLSAVKYLHENGIVHRDLKPENLLYLTPEENSKIMITDFGLSKMEQNGIMSTAC
GTPGYVAPEVLAQKPYSKAVDCWSIGVITYILLCGYPPFYEETESKLFEKIKEGYYEFES
PFWDDISESAKDFICHLLEKDPNERYTCEKALSHPWIDGNTALHRDIYPSVSLQIQKNFA
KSKWRQAFNAAAVVHHMRKLHMNLHSPGVRPEVENRPPETQASETSRPSSPEITITEAPV
LDHSVALPALTQLPCQHGRRPTAPGGRSLNCLVNGSLHISSSLVPMHQGSLAAGPCGCCS
SCLNIGSKGKSSYCSEPTLLKKANKKQNFKSEVMVPVKASGSSHCRAGQTGVCLIM
Target Bioclass
Transporter and channel
Family
Chloride channel CLIC family
Subcellular location
Cytoplasm
Function May insert into membranes and form chloride ion channels. May play a critical role in water-secreting cells, possibly through the regulation of chloride ion transport.
Uniprot ID
Q96NY7
Ensemble ID
ENST00000349499.3
HGNC ID
HGNC:2065

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 5 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K550(10.00); K576(2.04); K582(10.00); K598(8.24)  LDD0277  [1]
DBIA
 Probe Info  		C487(1.37)  LDD3312  [2]
IA-alkyne
 Probe Info  		C487(20.00)  LDD1461  [3]
IPM
 Probe Info  		C487(0.97)  LDD1702  [4]
NAIA_5
 Probe Info  		N.A.  LDD2223  [5]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0630  CCW28-3 231MFP C487(0.60)  LDD2214  [6]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C487(0.97)  LDD1702  [4]
 LDCM0625  F8 Ramos C641(1.36)  LDD2187  [7]
 LDCM0572  Fragment10 MDA-MB-231 C487(3.22)  LDD1465  [3]
 LDCM0573  Fragment11 MDA-MB-231 C487(3.07)  LDD1467  [3]
 LDCM0574  Fragment12 MDA-MB-231 C487(20.00)  LDD1468  [3]
 LDCM0575  Fragment13 MDA-MB-231 C487(1.86)  LDD1469  [3]
 LDCM0576  Fragment14 MDA-MB-231 C487(0.79)  LDD1471  [3]
 LDCM0580  Fragment21 MDA-MB-231 C487(1.17)  LDD1473  [3]
 LDCM0586  Fragment28 Ramos C641(0.50)  LDD2198  [7]
 LDCM0589  Fragment31 MDA-MB-231 C487(0.47)  LDD1477  [3]
 LDCM0468  Fragment33 MDA-MB-231 C487(14.87)  LDD1479  [3]
 LDCM0566  Fragment4 MDA-MB-231 C487(20.00)  LDD1461  [3]
 LDCM0599  Fragment41 MDA-MB-231 C487(0.44)  LDD1481  [3]
 LDCM0603  Fragment45 MDA-MB-231 C487(1.77)  LDD1482  [3]
 LDCM0614  Fragment56 MDA-MB-231 C487(1.31)  LDD1484  [3]
 LDCM0569  Fragment7 Ramos C641(0.55)  LDD2186  [7]
 LDCM0570  Fragment8 MDA-MB-231 C487(5.09)  LDD1462  [3]
 LDCM0571  Fragment9 MDA-MB-231 C487(3.55)  LDD1463  [3]
 LDCM0022  KB02 Ramos C641(0.36)  LDD2182  [7]
 LDCM0023  KB03 Ramos C641(1.56)  LDD2183  [7]
 LDCM0024  KB05 HMCB C487(1.37)  LDD3312  [2]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
6 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
7 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578