Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment33  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 58 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04232  4-trimethylaminobutyraldehyde dehydrogenase (ALDH9A1) C288 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 20.0
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C126 20.0
 LDTP03786  Glutaredoxin-1 (GLRX) C23 20.0
 LDTP05128  Glutathione S-transferase omega-1 (GSTO1) C32 20.0
 LDTP02502  Thioredoxin (TXN) C32 20.0
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 20.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 3.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C196 3.4
 LDTP06211  Caspase-8 (CASP8) C360 3.2
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 2.7
 LDTP09067  Thioredoxin domain-containing protein 5 (TXNDC5) C350 2.6
 LDTP07110  Putative transferase CAF17, mitochondrial (IBA57) C170 2.5
 LDTP03258  Thymidylate kinase (DTYMK) C117 2.5
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 2.3
 LDTP05346  Methylmalonate-semialdehyde/malonate-semialdehyde dehydrogenase [acylating], mitochondrial (ALDH6A1) C317 2.3
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 2.3
 LDTP14535  6-phosphogluconolactonase (PGLS) C32 2.3
 LDTP10177  Medium-chain acyl-CoA ligase ACSF2, mitochondrial (ACSF2) C64 2.3
 LDTP02223  Cathepsin B (CTSB) C211 2.2
 LDTP04076  Mitogen-activated protein kinase 9 (MAPK9) C177 2.0
 LDTP03400  Deoxycytidine kinase (DCK) C9 1.9
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1312 1.8
 LDTP11107  Serine/threonine-protein phosphatase CPPED1 (CPPED1) C54 1.8
 LDTP15427  Ribonuclease P protein subunit p25-like protein (RPP25L) C131 1.7
 LDTP05773  Peroxiredoxin-4 (PRDX4) C51 1.7
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 1.6
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 1.6
 LDTP00642  DNA-directed RNA polymerase I subunit RPA34 (POLR1G) C86 1.6
 LDTP03770  Alpha-adducin (ADD1) C68 1.6
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 1.6
 LDTP13449  Cleavage and polyadenylation specificity factor subunit 3 (CPSF3) C498 1.6
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C331 1.5
 LDTP12837  Mitogen-activated protein kinase kinase kinase 20 (MAP3K20) C22 1.5
 LDTP19669  Threonine synthase-like 1 (THNSL1) C324 1.4
 LDTP05859  Integrin-linked protein kinase (ILK) C346 1.4
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.4
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.3
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.3
 LDTP00479  Histone acetyltransferase type B catalytic subunit (HAT1) C101 1.3
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 1.2
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 1.2
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 1.2
 LDTP01633  Persulfide dioxygenase ETHE1, mitochondrial (ETHE1) C170 1.2
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 1.2
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.2
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.1
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 1.1
 LDTP16095  Ethylmalonyl-CoA decarboxylase (ECHDC1) C133 1.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.0
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 1.0
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 1.0
 LDTP04438  Succinate-semialdehyde dehydrogenase, mitochondrial (ALDH5A1) C340 0.9
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 0.9
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 0.9
 LDTP15290  5'-nucleotidase domain-containing protein 3 (NT5DC3) C276 0.8
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.7
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 0.7
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP11103  Thioredoxin domain-containing protein 17 (TXNDC17) C43 20.0
 LDTP10642  Chloride intracellular channel protein 6 (CLIC6) C487 14.9
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 8.9
 LDTP00244  Chloride intracellular channel protein 1 (CLIC1) C24 8.4
 LDTP03777  Nuclear pore complex protein Nup214 (NUP214) C728 6.4
 LDTP08769  Nuclear pore complex protein Nup93 (NUP93) C522 1.7
 LDTP05511  Cytoskeleton-associated protein 4 (CKAP4) C100 1.7
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.6
 LDTP02735  G2/mitotic-specific cyclin-B1 (CCNB1) C238 1.2
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 1.1
Transcription factor
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP12792  CDKN2A-interacting protein (CDKN2AIP) C516 1.4
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 1.3
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.3
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.3
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.1
Other
Click to Show/Hide to Show 44 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP14351  RAB7A-interacting MON1-CCZ1 complex subunit 1 (RIMOC1) C179 7.4
 LDTP06244  Nuclear mitotic apparatus protein 1 (NUMA1) C961 4.8
 LDTP07205  Telomere-associated protein RIF1 (RIF1) C2298 3.4
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 3.0
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 2.9
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 2.6
 LDTP07755  Dynamin-binding protein (DNMBP) C691 2.5
 LDTP13705  LIM and calponin homology domains-containing protein 1 (LIMCH1) C140 2.5
 LDTP12883  Constitutive coactivator of PPAR-gamma-like protein 1 (FAM120A) C531 2.4
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 2.4
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 2.2
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 2.2
 LDTP09626  Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) C464 2.2
 LDTP12412  Reticulon-4 (RTN4) C1101 2.1
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 2.1
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 2.0
 LDTP06362  Leucine-rich repeat-containing protein 41 (LRRC41) C297 1.9
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) C213 1.9
 LDTP14250  Cytoplasmic dynein 1 light intermediate chain 1 (DYNC1LI1) C51 1.8
 LDTP00229  Copper transport protein ATOX1 (ATOX1) C12 1.8
 LDTP10657  Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (ARAP1) C900 1.7
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.6
 LDTP16117  Mediator of RNA polymerase II transcription subunit 9 (MED9) C139 1.6
 LDTP05186  Large ribosomal subunit protein eL24 (RPL24) C6 1.6
 LDTP07037  WD repeat domain phosphoinositide-interacting protein 3 (WDR45B) C63 1.6
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 1.6
 LDTP13580  Coronin-1C (CORO1C) C420 1.6
 LDTP10864  Calponin-2 (CNN2) C164 1.5
 LDTP12443  Anillin (ANLN) C712 1.5
 LDTP12571  LanC-like protein 2 (LANCL2) C187 1.5
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.4
 LDTP11235  Protein PAXX (PAXX) C180 1.4
 LDTP06330  Plectin (PLEC) C4574 1.4
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.3
 LDTP15896  Ashwin (C2orf49) C10 1.3
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 1.3
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 1.3
 LDTP12669  Mediator of RNA polymerase II transcription subunit 17 (MED17) C649 1.2
 LDTP13964  MOB-like protein phocein (MOB4) C134 1.2
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 1.2
 LDTP09821  Stalled ribosome sensor GCN1 (GCN1) C1692 1.2
 LDTP05257  Receptor expression-enhancing protein 5 (REEP5) C18 1.1
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 1.1
 LDTP04487  Cyclin-H (CCNH) C244 0.9

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.