Details of the Target

General Information of Target

Target ID LDTP07205
Target Name Telomere-associated protein RIF1 (RIF1)
Gene Name RIF1
Gene ID 55183
Synonyms
Telomere-associated protein RIF1; Rap1-interacting factor 1 homolog
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTARGQSPLAPLLETLEDPSASHGGQTDAYLTLTSRMTGEEGKEVITEIEKKLPRLYKVL
KTHISSQNSELSSAALQALGFCLYNPKITSELSEANALELLSKLNDTIKNSDKNVRTRAL
WVISKQTFPSEVVGKMVSSIIDSLEILFNKGETHSAVVDFEALNVIVRLIEQAPIQMGEE
AVRWAKLVIPLVVHSAQKVHLRGATALEMGMPLLLQKQQEIASITEQLMTTKLISELQKL
FMSKNETYVLKLWPLFVKLLGRTLHRSGSFINSLLQLEELGFRSGAPMIKKIAFIAWKSL
IDNFALNPDILCSAKRLKLLMQPLSSIHVRTETLALTKLEVWWYLLMRLGPHLPANFEQV
CVPLIQSTISIDSNASPQGNSCHVATSPGLNPMTPVHKGASSPYGAPGTPRMNLSSNLGG
MATIPSIQLLGLEMLLHFLLGPEALSFAKQNKLVLSLEPLEHPLISSPSFFSKHANTLIT
AVHDSFVAVGKDAPDVVVSAIWKELISLVKSVTESGNKKEKPGSEVLTLLLKSLESIVKS
EVFPVSKTLVLMEITIKGLPQKVLGSPAYQVANMDILNGTPALFLIQLIFNNFLECGVSD
ERFFLSLESLVGCVLSGPTSPLAFSDSVLNVINQNAKQLENKEHLWKMWSVIVTPLTELI
NQTNEVNQGDALEHNFSAIYGALTLPVNHIFSEQRFPVATMKTLLRTWSELYRAFARCAA
LVATAEENLCCEELSSKIMSSLEDEGFSNLLFVDRIIYIITVMVDCIDFSPYNIKYQPKV
KSPQRPSDWSKKKNEPLGKLTSLFKLIVKVIYSFHTLSFKEAHSDTLFTIGNSITGIISS
VLGHISLPSMIRKIFATLTRPLALFYENSKLDEVPKVYSCLNNKLEKLLGEIIACLQFSY
TGTYDSELLEQLSPLLCIIFLHKNKQIRKQSAQFWNATFAKVMMLVYPEELKPVLTQAKQ
KFLLLLPGLETVEMMEESSGPYSDGTENSQLNVKISGMERKSNGKRDSFLAQTKNKKENM
KPAAKLKLESSSLKVKGEILLEEEKSTDFVFIPPEGKDAKERILTDHQKEVLKTKRCDIP
AMYNNLDVSQDTLFTQYSQEEPMEIPTLTRKPKEDSKMMITEEQMDSDIVIPQDVTEDCG
MAEHLEKSSLSNNECGSLDKTSPEMSNSNNDERKKALISSRKTSTECASSTENSFVVSSS
SVSNTTVAGTPPYPTSRRQTFITLEKFDGSENRPFSPSPLNNISSTVTVKNNQETMIKTD
FLPKAKQREGTFSKSDSEKIVNGTKRSSRRAGKAEQTGNKRSKPLMRSEPEKNTEESVEG
IVVLENNPPGLLNQTECVSDNQVHLSESTMEHDNTKLKAATVENAVLLETNTVEEKNVEI
NLESKENTPPVVISADQMVNEDSQVQITPNQKTLRRSSRRRSEVVESTTESQDKENSHQK
KERRKEEEKPLQKSPLHIKDDVLPKQKLIAEQTLQENLIEKGSNLHEKTLGETSANAETE
QNKKKADPENIKSEGDGTQDIVDKSSEKLVRGRTRYQTRRASQGLLSSIENSESDSSEAK
EEGSRKKRSGKWKNKSNESVDIQDQEEKVVKQECIKAENQSHDYKATSEEDVSIKSPICE
KQDESNTVICQDSTVTSDLLQVPDDLPNVCEEKNETSKYAEYSFTSLPVPESNLRTRNAI
KRLHKRDSFDNCSLGESSKIGISDISSLSEKTFQTLECQHKRSRRVRRSKGCDCCGEKSQ
PQEKSLIGLKNTENNDVEISETKKADVQAPVSPSETSQANPYSEGQFLDEHHSVNFHLGL
KEDNDTINDSLIVSETKSKENTMQESLPSGIVNFREEICDMDSSEAMSLESQESPNENFK
TVGPCLGDSKNVSQESLETKEEKPEETPKMELSLENVTVEGNACKVTESNLEKAKTMELN
VGNEASFHGQERTKTGISEEAAIEENKRNDDSEADTAKLNAKEVATEEFNSDISLSDNTT
PVKLNAQTEISEQTAAGELDGGNDVSDLHSSEETNTKMKNNEEMMIGEAMAETGHDGETE
NEGITTKTSKPDEAETNMLTAEMDNFVCDTVEMSTEEGIIDANKTETNTEYSKSEEKLDN
NQMVMESDILQEDHHTSQKVEEPSQCLASGTAISELIIEDNNASPQKLRELDPSLVSAND
SPSGMQTRCVWSPLASPSTSILKRGLKRSQEDEISSPVNKVRRVSFADPIYQAGLADDID
RRCSIVRSHSSNSSPIGKSVKTSPTTQSKHNTTSAKGFLSPGSRSPKFKSSKKCLISEMA
KESIPCPTESVYPPLVNCVAPVDIILPQITSNMWARGLGQLIRAKNIKTIGDLSTLTASE
IKTLPIRSPKVSNVKKALRIYHEQQVKTRGLEEIPVFDISEKTVNGIENKSLSPDEERLV
SDIIDPVALEIPLSKNLLAQISALALQLDSEDLHNYSGSQLFEMHEKLSCMANSVIKNLQ
SRWRSPSHENSI
Target Bioclass
Other
Family
RIF1 family
Subcellular location
Nucleus
Function
Key regulator of TP53BP1 that plays a key role in the repair of double-strand DNA breaks (DSBs) in response to DNA damage: acts by promoting non-homologous end joining (NHEJ)-mediated repair of DSBs. In response to DNA damage, interacts with ATM-phosphorylated TP53BP1. Interaction with TP53BP1 leads to dissociate the interaction between NUDT16L1/TIRR and TP53BP1, thereby unmasking the tandem Tudor-like domain of TP53BP1 and allowing recruitment to DNA DSBs. Once recruited to DSBs, RIF1 and TP53BP1 act by promoting NHEJ-mediated repair of DSBs. In the same time, RIF1 and TP53BP1 specifically counteract the function of BRCA1 by blocking DSBs resection via homologous recombination (HR) during G1 phase. Also required for immunoglobulin class-switch recombination (CSR) during antibody genesis, a process that involves the generation of DNA DSBs. Promotes NHEJ of dysfunctional telomeres.
Uniprot ID
Q5UIP0
Ensemble ID
ENST00000243326.9
HGNC ID
HGNC:23207

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.E1598K .
CCK81 SNV: p.C1734R .
HCT116 Insertion: p.E1442GfsTer4 DBIA    Probe Info 
HCT15 SNV: p.A293V; p.E1878K .
HT115 SNV: p.E1857Ter .
ICC10 SNV: p.K1312N .
ICC106 SNV: p.K1312N .
ICC108 SNV: p.K1312N .
JHH7 SNV: p.K449N .
KYSE150 SNV: p.S1089C .
LNCaP clone FGC SNV: p.P1455T .
MCC13 SNV: p.P410L
Substitution: p.P1310Ter		 .
NCIH2172 SNV: p.R785T .
NCIH716 SNV: p.S511A .
OPM2 SNV: p.S269G .
REH SNV: p.V193A .
RKO SNV: p.E1430G .
RL SNV: p.M739I .
SNGM SNV: p.Q1874H .
SUPT1 SNV: p.V841I .
VMRCRCW SNV: p.E1143G .
WM1552C SNV: p.E1885Ter .
YSCCC SNV: p.E727K; p.P1163S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 35 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		2.42  LDD0215  [2]
TH211
 Probe Info  		Y947(17.48); Y2361(10.03); Y404(5.99); Y2211(5.64)  LDD0257  [3]
TH216
 Probe Info  		Y404(7.84)  LDD0259  [3]
STPyne
 Probe Info  		K1528(10.00)  LDD0277  [4]
P12
 Probe Info  		11.91  LDD0202  [5]
JZ128-DTB
 Probe Info  		N.A.  LDD0462  [6]
BTD
 Probe Info  		C2274(0.64)  LDD2089  [7]
DA-P3
 Probe Info  		4.57  LDD0180  [8]
AHL-Pu-1
 Probe Info  		C1155(10.64); C2298(5.06); C2274(2.03); C2169(2.00)  LDD0168  [9]
Alkyne-RA190
 Probe Info  		4.48  LDD0299  [10]
HHS-475
 Probe Info  		Y404(0.34)  LDD0264  [11]
DBIA
 Probe Info  		C880(1.25); C2450(1.10); C1718(1.02); C2169(1.00)  LDD0078  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C2274(0.00); C312(0.00); C82(0.00); C1692(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C1718(0.00); C2169(0.00); C312(0.00)  LDD0032  [15]
Lodoacetamide azide
 Probe Info  		C2169(0.00); C312(0.00); C1155(0.00); C1718(0.00)  LDD0037  [14]
NAIA_4
 Probe Info  		C1692(0.00); C2169(0.00)  LDD2226  [16]
TFBX
 Probe Info  		C1718(0.00); C1692(0.00)  LDD0027  [17]
WYneN
 Probe Info  		C2169(0.00); C1155(0.00); C312(0.00)  LDD0021  [18]
aHNE
 Probe Info  		N.A.  LDD0001  [18]
Compound 10
 Probe Info  		C1718(0.00); C2169(0.00); C2274(0.00); C312(0.00)  LDD2216  [19]
Compound 11
 Probe Info  		C1692(0.00); C1718(0.00); C2169(0.00); C2274(0.00)  LDD2213  [19]
ENE
 Probe Info  		C2450(0.00); C1155(0.00); C880(0.00); C1865(0.00)  LDD0006  [18]
IPM
 Probe Info  		C312(0.00); C2169(0.00); C2274(0.00); C1718(0.00)  LDD0005  [18]
PPMS
 Probe Info  		N.A.  LDD0008  [18]
SF
 Probe Info  		N.A.  LDD0028  [20]
VSF
 Probe Info  		C1904(0.00); C2126(0.00); C2169(0.00); C1619(0.00)  LDD0007  [18]
Phosphinate-6
 Probe Info  		C1735(0.00); C2223(0.00); C312(0.00); C1734(0.00)  LDD0018  [21]
1c-yne
 Probe Info  		K1870(0.00); K125(0.00); K103(0.00)  LDD0228  [22]
Acrolein
 Probe Info  		C1718(0.00); C1692(0.00)  LDD0217  [23]
Methacrolein
 Probe Info  		C1155(0.00); C2450(0.00); C1692(0.00); C1718(0.00)  LDD0218  [23]
W1
 Probe Info  		N.A.  LDD0236  [24]
AOyne
 Probe Info  		7.90  LDD0443  [25]
NAIA_5
 Probe Info  		C2274(0.00); C2450(0.00); C1718(0.00)  LDD2223  [16]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe3
 Probe Info  		14.67  LDD0465  [26]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C2450(0.92)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C2274(1.52)  LDD2152  [7]
 LDCM0025  4SU-RNA HEK-293T C1155(10.64); C2298(5.06); C2274(2.03); C2169(2.00)  LDD0168  [9]
 LDCM0026  4SU-RNA+native RNA HEK-293T C2286(13.13); C2298(16.55); C2126(2.27); C2068(6.21)  LDD0169  [9]
 LDCM0214  AC1 HCT 116 C1732(0.88); C1155(0.87); C1734(0.92); C1735(0.88)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C1732(0.94); C1155(0.78); C1630(1.42); C1650(1.42)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C1155(0.97); C1692(1.05); C1865(0.97); C1904(0.75)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C1155(1.01); C1692(1.17); C1865(1.13); C1904(0.94)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C1155(1.00); C1692(0.90); C1865(1.04); C1904(0.84)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C1155(1.18); C1692(1.04); C1865(1.21); C1904(0.96)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C1155(1.07); C1692(0.78); C1865(1.29); C1904(1.03)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C1155(1.18); C1692(1.39); C1865(1.52); C1904(0.94)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C1155(1.13); C1692(1.33); C1865(1.21); C1904(0.99)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C1155(0.97); C1692(1.04); C1865(1.22); C1904(0.84)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C1155(0.88); C1692(1.13); C1865(0.90); C1904(0.77)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C1155(0.95); C1692(0.91); C1865(0.97); C1904(0.86)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C1732(1.19); C1155(0.84); C1630(1.65); C1650(1.65)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C1155(1.11); C1692(1.15); C1865(1.08); C1904(0.96)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C1155(1.00); C1692(1.14); C1865(1.14); C1904(1.14)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C1155(1.04); C1692(1.12); C1865(1.14); C1904(1.15)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C1732(0.78); C1155(1.00); C1734(0.91); C1735(1.09)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C1732(0.85); C1155(1.20); C1734(0.96); C1735(1.13)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C1732(0.98); C1155(1.40); C1734(1.02); C1735(1.36)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C1732(1.05); C1155(1.33); C1734(0.96); C1735(1.24)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C1732(1.33); C1155(1.09); C1734(0.96); C1735(1.38)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C1732(1.18); C1155(1.14); C1734(1.00); C1735(0.94)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C1732(1.17); C1155(1.14); C1734(1.10); C1735(1.20)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C1732(0.99); C1155(0.78); C1630(1.09); C1650(1.09)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C1732(0.91); C1155(1.10); C1734(1.17); C1735(1.25)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C1732(1.29); C1155(0.99); C1734(0.87); C1735(1.00)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C1732(0.93); C1155(1.01); C1734(1.05); C1735(1.11)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C1732(1.48); C1155(1.06); C1734(0.85); C1735(0.94)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C1732(1.15); C1155(1.04); C1734(0.89); C1735(0.97)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C1732(0.88); C1155(1.01); C1734(1.00); C1735(1.13)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C1732(0.90); C1155(1.18); C1734(0.92); C1735(1.38)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C1732(1.21); C1155(1.27); C1734(1.00); C1735(1.37)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C1732(1.13); C1155(0.55); C1734(0.36); C1735(1.10)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C1732(0.72); C1155(0.67); C1734(0.33); C1735(0.78)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C1732(1.11); C1155(0.73); C1734(0.41); C1735(0.84)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C1732(0.67); C1155(0.68); C1734(0.45); C1735(0.71)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C1732(1.00); C1155(0.80); C1734(0.50); C1735(0.87)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C1732(0.85); C1155(0.82); C1734(0.45); C1735(0.84)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C1732(1.11); C1155(0.72); C1734(0.54); C1735(0.89)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C1732(0.97); C1155(0.73); C1734(0.49); C1735(0.93)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C1732(0.90); C1155(0.92); C1734(0.51); C1735(0.75)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C1732(1.01); C1155(0.66); C1734(0.56); C1735(0.56)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C1732(1.12); C1155(0.82); C1734(0.54); C1735(0.71)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C1732(0.92); C1155(0.77); C1734(0.56); C1735(0.62)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C1732(0.88); C1155(0.99); C1630(1.58); C1650(1.58)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C1732(0.93); C1155(0.87); C1734(0.61); C1735(0.73)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C1732(1.08); C1155(0.95); C1734(0.63); C1735(0.82)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C1732(1.09); C1155(0.73); C1734(0.49); C1735(0.62)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C1732(0.97); C1734(0.97); C2450(1.10); C2169(1.10)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C1734(0.93); C1732(1.04); C1155(1.04); C1865(1.20)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C1732(0.99); C1734(0.99); C1155(1.07); C2169(1.08)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C1732(0.89); C1155(0.98); C1734(1.00); C880(1.00)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C1155(0.86); C1734(0.90); C1732(1.07); C880(1.22)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C1732(0.95); C1155(1.00); C1734(1.05); C880(1.66)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C1732(0.86); C1734(0.99); C1155(1.09); C880(1.32)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C2450(0.84); C1865(0.86); C1734(0.86); C1155(0.90)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C1155(0.93); C1734(0.95); C1732(0.96); C880(1.00)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C1734(0.82); C1732(0.99); C1155(1.00); C2450(1.05)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C1734(0.91); C1732(1.00); C1155(1.00); C1865(1.22)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C1732(1.09); C1155(1.18); C1734(1.28); C2450(1.83)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C1732(0.95); C1155(1.00); C1692(2.39); C1734(0.95)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C1732(0.94); C1155(1.03); C1692(2.62); C1734(0.97)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C1732(1.00); C1155(0.94); C1692(1.72); C1734(1.07)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C1732(1.26); C1155(1.07); C1692(2.10); C1734(1.24)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C2169(0.14); C1734(0.56); C1735(0.73); C2274(0.78)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C2169(0.19); C1734(0.70); C1732(0.85); C1735(0.87)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C2169(0.14); C1734(0.56); C1732(0.69); C2274(0.79)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C2450(0.78); C2169(0.81); C1155(0.92); C1904(0.93)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C2169(0.17); C1734(0.61); C1732(0.71); C1735(0.73)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C2169(0.18); C1734(0.64); C1732(0.69); C1735(0.78)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C2169(0.16); C1734(0.67); C1732(0.79); C2274(0.84)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C2169(0.14); C1734(0.56); C1732(0.64); C2274(0.79)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C2169(0.12); C1734(0.50); C2274(0.77); C1732(0.80)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C1155(0.65); C880(0.88); C312(0.95); C731(0.97)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C1155(1.00); C312(1.03); C880(1.07); C1865(1.10)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C1155(0.74); C880(0.90); C312(1.08); C731(1.09)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C1155(0.76); C1865(1.12); C312(1.13); C880(1.16)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C880(0.96); C1155(0.99); C731(1.11); C312(1.11)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C2169(0.69); C2450(0.76); C2274(0.84); C1155(0.85)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C1155(0.90); C880(0.95); C1865(1.11); C312(1.13)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C1155(0.82); C880(0.89); C2450(1.07); C731(1.08)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C880(1.05); C312(1.22); C731(1.23); C2450(1.24)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C880(0.92); C1155(1.08); C718(1.11); C730(1.11)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C1155(1.11); C731(1.18); C880(1.19); C718(1.23)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C718(0.88); C731(0.88); C312(0.90); C2450(0.92)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C718(0.76); C731(0.76); C312(0.87); C1865(0.89)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C312(0.83); C880(0.90); C718(0.98); C731(0.98)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C718(0.91); C731(0.91); C730(0.97); C880(0.99)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C718(0.96); C731(0.96); C312(1.05); C1865(1.06)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C2169(0.67); C1155(0.77); C2450(0.77); C2274(0.80)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C718(1.01); C731(1.01); C312(1.09); C2450(1.24)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C718(0.82); C731(0.82); C730(0.89); C312(0.94)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C718(0.92); C731(0.92); C2450(1.07); C730(1.09)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C718(0.92); C731(0.92); C880(1.06); C2450(1.07)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C312(0.99); C718(1.00); C731(1.00); C880(1.00)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C718(1.00); C731(1.00); C2450(1.05); C1865(1.16)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C731(0.88); C730(0.92); C718(0.93); C2450(1.06)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C718(0.91); C731(0.93); C730(0.94); C1735(0.97)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C1155(0.88); C731(0.90); C880(0.98); C730(0.99)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C730(1.10); C731(1.11); C1734(1.18); C1904(1.18)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C2169(0.57); C2450(0.73); C2274(0.75); C1155(0.75)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C1734(0.92); C731(1.05); C730(1.10); C1735(1.14)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C1155(0.71); C880(0.81); C731(0.82); C730(0.82)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C1155(0.78); C731(0.89); C730(0.91); C880(0.96)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C731(1.02); C1904(1.02); C1735(1.04); C2450(1.07)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C880(0.88); C1735(0.95); C1734(1.03); C731(1.05)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C1904(0.85); C880(1.01); C730(1.15); C1735(1.16)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C880(1.20); C1735(1.24); C731(1.25); C730(1.25)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C1865(0.97); C2450(1.06); C1630(1.07); C1650(1.07)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C1865(0.91); C312(0.95); C1732(0.96); C1734(0.96)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C1630(0.70); C1650(0.70); C2450(1.05); C2274(1.11)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C1155(0.78); C1865(0.87); C2274(1.01); C312(1.04)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C2450(1.10); C312(1.16); C731(1.16); C718(1.17)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C1865(0.90); C312(0.92); C1630(0.96); C1650(0.96)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C1630(0.91); C1650(0.91); C1865(1.07); C2450(1.12)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C1630(0.75); C1650(0.75); C312(1.03); C2450(1.07)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C1630(0.66); C1650(0.66); C2450(1.10); C1732(1.13)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C1630(0.85); C1650(0.85); C1155(0.94); C2450(0.96)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C1155(0.87); C1865(0.94); C1630(0.95); C1650(0.95)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C1630(0.80); C1650(0.80); C2450(1.08); C2274(1.21)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C312(0.76); C1732(0.80); C880(0.85); C2450(0.86)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C312(0.73); C2450(0.81); C1732(0.84); C880(0.88)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C1155(0.66); C1865(0.72); C2169(0.90); C2450(0.92)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C312(0.68); C2450(0.76); C2169(0.92); C880(1.00)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C2169(0.72); C880(0.82); C1732(0.87); C2450(0.88)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C2450(0.73); C312(0.85); C718(0.96); C731(0.97)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C2450(0.85); C312(1.02); C880(1.06); C1732(1.26)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C1732(0.95); C880(0.95); C312(1.01); C1155(1.18)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C2450(0.75); C312(0.99); C880(1.00); C1732(1.11)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C2450(0.99); C880(1.00); C312(1.01); C1732(1.09)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C2450(0.76); C1732(0.90); C312(0.91); C718(1.10)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C312(0.79); C718(0.95); C2450(0.95); C731(0.96)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C1732(0.89); C718(0.96); C731(0.98); C2169(1.00)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C1865(0.78); C1155(0.79); C2274(0.95); C731(0.96)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C312(0.70); C880(0.89); C2450(1.05); C730(1.05)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C312(0.34); C2450(0.67); C1732(0.85); C718(0.85)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C2450(0.92); C1732(1.04); C312(1.21); C718(1.44)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C2450(1.26); C1904(1.37); C731(1.41); C730(1.41)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C718(1.13); C731(1.19); C2450(1.20); C730(1.21)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C1692(1.00); C718(1.02); C2169(1.06); C731(1.10)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C718(1.00); C1692(1.04); C731(1.09); C2450(1.20)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C718(0.80); C731(0.99); C312(1.00); C1692(1.00)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C718(0.92); C312(1.02); C1692(1.07); C1904(1.07)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C1692(1.07); C718(1.09); C2450(1.14); C1904(1.15)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C2169(0.78); C312(0.96); C1865(1.04); C880(1.06)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C2450(0.98); C1692(1.15); C730(1.20); C731(1.28)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C1692(1.10); C730(1.14); C2450(1.17); C718(1.17)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C718(0.94); C1692(0.96); C731(1.06); C730(1.10)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C1692(0.81); C718(0.90); C2450(0.90); C731(1.03)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C718(0.83); C731(0.94); C730(1.04); C1692(1.07)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C1692(0.78); C2450(0.86); C718(1.07); C730(1.15)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C2450(1.11); C718(1.13); C731(1.15); C730(1.19)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C312(0.84); C2274(0.87); C1904(1.11); C731(1.19)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C1904(0.78); C2274(0.82); C312(0.86); C2169(0.88)  LDD0683  [12]
 LDCM0248  AKOS034007472 HCT 116 C1732(1.09); C1155(0.87); C1630(1.09); C1650(1.09)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C1155(0.72); C1865(0.73); C731(0.97); C730(0.98)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C1732(0.85); C1734(0.91); C2450(0.99); C1865(1.03)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 11.61  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C880(1.25); C2450(1.10); C1718(1.02); C2169(1.00)  LDD0078  [12]
 LDCM0088  C45 HEK-293T 11.91  LDD0202  [5]
 LDCM0108  Chloroacetamide HeLa C1155(0.00); C1718(0.00); C1904(0.00); H2362(0.00)  LDD0222  [23]
 LDCM0632  CL-Sc Hep-G2 C1718(20.00); C2450(0.85); C1718(0.52); C312(0.22)  LDD2227  [16]
 LDCM0367  CL1 HCT 116 C1630(0.70); C1650(0.70); C312(0.78); C2169(0.86)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C2169(0.69); C2274(0.83); C2450(0.88); C1904(0.97)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C2450(0.76); C2169(0.86); C1904(0.89); C2274(0.91)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C1732(0.68); C1155(0.71); C2450(0.81); C1865(0.82)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C1155(0.77); C1865(0.78); C2450(0.85); C2274(0.86)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C1732(0.72); C1865(0.80); C1734(0.80); C1155(0.82)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C1155(0.72); C1865(0.80); C1734(0.86); C2274(0.88)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C2169(0.17); C1734(0.63); C1732(0.82); C2274(0.88)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C2169(0.15); C1734(0.65); C1732(0.66); C1155(0.75)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C2169(0.17); C1734(0.67); C1732(0.68); C2274(0.82)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C2169(0.13); C1734(0.56); C1732(0.77); C1155(0.78)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C2169(0.17); C1734(0.77); C2274(0.88); C1732(0.96)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C2169(0.66); C1155(1.05); C1904(1.06); C2274(1.06)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C2169(0.10); C1734(0.53); C1732(0.75); C2274(0.79)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C2169(0.13); C1734(0.58); C1732(0.76); C1735(0.79)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C1155(0.79); C312(0.86); C1865(0.96); C718(1.01)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C880(1.00); C1155(1.06); C731(1.09); C312(1.10)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C312(0.94); C731(0.94); C1155(0.97); C1865(0.99)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C880(0.92); C731(1.05); C312(1.06); C718(1.09)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C880(0.92); C1155(1.00); C312(1.07); C731(1.07)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C718(1.22); C731(1.22); C312(1.36); C1155(1.38)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C2450(0.97); C718(0.97); C731(0.97); C880(1.05)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C2450(0.91); C718(0.96); C731(0.96); C312(1.01)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C2169(0.73); C2450(0.95); C2274(0.98); C1904(1.14)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C312(0.95); C2450(0.97); C880(1.04); C718(1.08)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C2450(0.72); C880(0.72); C1865(1.11); C1155(1.19)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C1155(0.85); C731(0.94); C1904(0.98); C1865(1.00)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C1735(0.99); C1904(1.01); C1865(1.02); C731(1.04)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C880(1.07); C731(1.08); C730(1.10); C1904(1.14)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C2450(0.79); C312(0.85); C718(0.89); C730(0.89)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C1630(0.78); C1650(0.78); C1865(0.85); C312(0.87)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C1630(0.53); C1650(0.53); C2450(0.82); C1155(0.89)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C1630(0.74); C1650(0.74); C2450(0.87); C1865(0.90)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C2169(0.82); C2274(0.88); C1630(0.92); C1650(0.92)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C1630(0.84); C1650(0.84); C1904(0.87); C2169(0.94)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C2169(0.73); C1692(0.76); C1155(0.81); C1904(0.87)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C2274(0.92); C1630(0.95); C1650(0.95); C2169(0.96)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C2169(0.85); C718(0.87); C731(0.87); C1692(0.93)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C2450(0.90); C880(0.91); C718(1.00); C731(1.00)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C2169(0.76); C1692(0.79); C1732(0.94); C1155(0.98)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C312(0.68); C1630(0.81); C1650(0.81); C880(0.91)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C2169(0.75); C1692(0.90); C2450(0.94); C718(1.00)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C2169(0.72); C2450(0.89); C1692(0.94); C718(0.98)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C2169(0.65); C1692(0.77); C1155(0.88); C730(0.98)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C2169(0.92); C1630(0.97); C1650(0.97); C880(1.05)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C1732(1.31); C1155(1.13); C1630(1.49); C1650(1.49)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C1732(1.63); C1155(1.03); C1630(1.24); C1650(1.24)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C1732(2.47); C1155(1.11); C1630(1.17); C1650(1.17)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C1732(1.65); C1155(1.07); C1630(1.30); C1650(1.30)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C1732(1.46); C1155(1.22); C1630(1.30); C1650(1.30)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C1732(1.18); C1155(1.21); C1630(1.37); C1650(1.37)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C1155(1.04); C1630(1.00); C1650(1.00); C1692(0.94)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C1732(1.21); C1155(1.04); C1630(1.03); C1650(1.03)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C1732(1.53); C1155(0.87); C1735(0.63); C1865(0.80)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C1732(1.51); C1155(1.05); C1734(1.28); C1735(0.91)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C1732(1.12); C1155(0.99); C1734(1.11); C1735(0.79)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C1732(1.20); C1155(1.04); C1734(0.90); C1735(1.11)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C1732(5.32); C1155(1.13); C1734(1.07); C1735(1.04)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C1732(1.34); C1155(1.10); C1734(0.90); C1735(0.79)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C1732(1.33); C1155(1.08); C1734(0.92); C1735(1.67)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C1732(1.70); C1155(1.01); C1734(1.24); C1735(0.74)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C1155(1.01); C1630(1.22); C1650(1.22); C1692(0.89)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C1732(1.23); C1155(0.97); C1734(1.10); C1735(0.65)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C1732(1.32); C1155(1.19); C1734(1.06); C1735(0.58)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C1732(2.04); C1155(0.91); C1734(0.85); C1735(0.67)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C1732(1.80); C1155(1.03); C1734(0.99); C1735(0.71)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C1732(1.96); C1155(0.88); C1734(0.89); C1735(0.64)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C1732(1.85); C1155(1.05); C1734(0.95); C1735(0.90)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C1732(1.05); C1155(0.96); C1630(0.76); C1650(0.76)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C1732(0.94); C1155(0.84); C1630(0.57); C1650(0.57)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C1732(0.95); C1155(0.79); C1630(0.74); C1650(0.74)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C1732(0.82); C1155(0.82); C1630(0.85); C1650(0.85)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C1155(1.07); C1630(1.01); C1650(1.01); C1692(0.92)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C1732(0.96); C1155(0.85); C1630(0.96); C1650(0.96)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C1732(1.03); C1155(1.15); C1630(1.18); C1650(1.18)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C1732(1.13); C1155(1.11); C1630(1.12); C1650(1.12)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C1732(1.00); C1155(0.95); C1630(0.84); C1650(0.84)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C1732(0.99); C1155(1.00); C1630(0.76); C1650(0.76)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C1732(0.88); C1155(0.95); C1630(0.95); C1650(0.95)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C1732(0.95); C1155(0.85); C1630(0.78); C1650(0.78)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C1732(0.92); C1155(0.75); C1630(0.82); C1650(0.82)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C1732(0.99); C1155(0.85); C1630(0.76); C1650(0.76)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C1732(0.91); C1155(0.84); C1630(0.72); C1650(0.72)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C1155(1.17); C1630(0.89); C1650(0.89); C1692(1.03)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C1732(1.13); C1155(0.89); C1630(0.75); C1650(0.75)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C1732(0.87); C1155(1.21); C1630(1.22); C1650(1.22)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C1732(0.98); C1155(1.32); C1630(1.15); C1650(1.15)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C1732(0.98); C1155(0.97); C1630(1.38); C1650(1.38)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C1732(0.70); C1155(0.95); C1630(1.26); C1650(1.26)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C1732(0.80); C1155(1.03); C1630(1.10); C1650(1.10)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C1732(0.89); C1155(1.02); C1630(1.49); C1650(1.49)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C1732(0.88); C1155(1.03); C1630(1.34); C1650(1.34)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C1732(0.75); C1155(1.10); C1630(1.09); C1650(1.09)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C1732(1.23); C1155(1.10); C1630(0.76); C1650(0.76)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C1155(1.00); C1630(1.05); C1650(1.05); C1692(0.79)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C1732(0.97); C1155(1.10); C1630(1.12); C1650(1.12)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C1732(0.98); C1155(1.07); C1630(1.31); C1650(1.31)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C1732(0.83); C1155(1.30); C1630(1.03); C1650(1.03)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C1732(0.85); C1155(1.37); C1630(1.16); C1650(1.16)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C1732(0.94); C1155(1.11); C1630(1.32); C1650(1.32)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C1732(0.72); C1155(0.75); C1630(0.96); C1650(0.96)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C1732(0.77); C1155(0.73); C1630(0.77); C1650(0.77)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C1732(0.97); C1155(0.84); C1630(1.04); C1650(1.04)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C1732(0.75); C1155(0.71); C1630(1.24); C1650(1.24)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C1155(1.05); C1630(1.30); C1650(1.30); C1692(1.09)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C1732(0.90); C1155(0.78); C1630(0.86); C1650(0.86)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C1732(0.76); C1155(0.68); C1630(0.92); C1650(0.92)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C1732(0.67); C1155(0.66); C1630(1.21); C1650(1.21)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C1732(0.81); C1155(0.73); C1630(1.18); C1650(1.18)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C1732(0.88); C1155(0.83); C1630(1.32); C1650(1.32)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C1732(0.93); C1155(0.75); C1630(1.05); C1650(1.05)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C1732(0.82); C1155(0.73); C1630(0.76); C1650(0.76)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C1732(0.75); C1155(0.72); C1630(0.76); C1650(0.76)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C1732(0.77); C1155(0.69); C1630(1.38); C1650(1.38)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C1732(0.80); C1155(0.75); C1630(1.53); C1650(1.53)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C1155(1.11); C1630(0.95); C1650(0.95); C1692(0.85)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C1732(0.70); C1155(0.60); C1630(0.92); C1650(0.92)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C1732(0.88); C1155(0.86); C1734(0.87); C1735(0.88)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C1732(0.89); C1155(0.91); C1734(0.97); C1735(0.89)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C1732(0.71); C1155(0.81); C1734(0.67); C1735(0.71)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C1732(0.95); C1155(0.90); C1734(0.92); C1735(0.95)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C1732(0.94); C1155(0.89); C1734(0.91); C1735(0.94)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C1732(0.92); C1155(0.80); C1734(0.94); C1735(0.92)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C1732(0.82); C1155(0.87); C1734(0.87); C1735(0.82)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C1732(0.93); C1155(1.02); C1734(0.89); C1735(0.93)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C1732(0.86); C1155(0.85); C1734(0.78); C1735(0.86)  LDD0811  [12]
 LDCM0634  CY-0357 Hep-G2 C2169(0.64); C1692(0.24)  LDD2228  [16]
 LDCM0028  Dobutamine HEK-293T 4.57  LDD0180  [8]
 LDCM0495  E2913 HEK-293T C1692(1.14); C1155(0.90); C1718(0.98); C880(1.07)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C2274(3.55); C2169(1.62); C2450(1.42); C1718(1.07)  LDD1702  [7]
 LDCM0625  F8 Ramos C2450(1.05); C2169(1.07)  LDD2187  [28]
 LDCM0572  Fragment10 MDA-MB-231 C2298(20.00)  LDD1465  [29]
 LDCM0573  Fragment11 MDA-MB-231 C2298(1.34)  LDD1467  [29]
 LDCM0574  Fragment12 Ramos C2450(1.26); C1692(0.59)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C2450(1.14); C1692(0.75); C2169(1.00)  LDD2192  [28]
 LDCM0576  Fragment14 MDA-MB-231 C2298(20.00)  LDD1471  [29]
 LDCM0579  Fragment20 Ramos C2450(2.09); C1692(0.72)  LDD2194  [28]
 LDCM0580  Fragment21 MDA-MB-231 C2298(0.89)  LDD1473  [29]
 LDCM0582  Fragment23 Ramos C2450(0.69); C1692(0.85)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C2450(0.89); C1692(0.85); C2169(0.77)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C2450(0.83); C1692(0.72); C2169(1.02)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C2450(1.08); C1692(0.93)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C2450(0.97); C1692(0.79)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C2450(1.66); C2169(1.08)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C1732(0.89); C1155(1.11); C1630(1.37); C1650(1.37)  LDD0785  [12]
 LDCM0596  Fragment38 Ramos C2450(1.23); C1692(0.73); C2169(0.96)  LDD2203  [28]
 LDCM0566  Fragment4 MDA-MB-231 C2298(20.00)  LDD1461  [29]
 LDCM0599  Fragment41 MDA-MB-231 C2298(1.21)  LDD1481  [29]
 LDCM0603  Fragment45 MDA-MB-231 C2298(20.00)  LDD1482  [29]
 LDCM0427  Fragment51 HCT 116 C1732(2.19); C1155(1.06); C1734(1.12); C1735(0.84)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C2450(1.04)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C2450(1.19)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C2450(2.44)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C1692(0.75); C2169(0.37)  LDD2188  [28]
 LDCM0116  HHS-0101 DM93 Y404(0.34)  LDD0264  [11]
 LDCM0119  HHS-0401 DM93 Y404(0.22)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y404(0.21)  LDD0268  [11]
 LDCM0107  IAA HeLa H2362(0.00); H2229(0.00)  LDD0221  [23]
 LDCM0179  JZ128 PC-3 N.A.  LDD0462  [6]
 LDCM0022  KB02 HCT 116 C730(16.58); C731(16.58); C880(7.67); C2169(2.61)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C730(20.00); C731(20.00); C880(7.95); C2169(1.70)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C730(20.00); C731(20.00); C880(7.19); C2169(2.41)  LDD0082  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C1865(0.94)  LDD2102  [7]
 LDCM0109  NEM HeLa H2229(0.00); H483(0.00); H474(0.00)  LDD0223  [23]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C2274(0.64)  LDD2089  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C2274(0.89)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C2274(1.07)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C2450(0.38)  LDD2096  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C2274(0.93)  LDD2098  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C2274(1.12)  LDD2105  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C2450(1.06)  LDD2107  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C2274(2.00); C1865(0.93)  LDD2109  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C1865(1.11)  LDD2111  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C2450(1.02)  LDD2118  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C2274(0.88); C2450(1.03)  LDD2123  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C2274(1.19); C2450(0.71)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C2450(1.22)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C2274(1.66); C2450(0.97)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C2274(0.80)  LDD2128  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C2274(1.36)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C2450(0.86)  LDD2137  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C2274(1.12); C2450(0.87)  LDD2140  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C2274(0.87)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C2450(1.89)  LDD2144  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C2450(1.20); C82(0.35)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C82(0.63); C2450(0.59)  LDD2207  [30]
 LDCM0131  RA190 MM1.R 4.48  LDD0299  [10]
 LDCM0021  THZ1 HCT 116 C880(1.10); C1732(1.16); C1734(1.16); C1735(1.16)  LDD2173  [12]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit (PPP1CA) PPP phosphatase family P62136

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
6 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 A chemical probe unravels the reactive proteome of health-associated catechols. Chem Sci. 2023 Jul 22;14(32):8635-8643. doi: 10.1039/d3sc00888f. eCollection 2023 Aug 16.
Mass spectrometry data entry: PXD043348
9 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
10 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
19 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
20 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
23 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
24 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
25 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
26 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.