Details of the Target

General Information of Target

Target ID LDTP08018
Target Name Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1)
Gene Name ZC3HAV1
Gene ID 56829
Synonyms
ZC3HDC2; Zinc finger CCCH-type antiviral protein 1; ADP-ribosyltransferase diphtheria toxin-like 13; ARTD13; Inactive Poly [ADP-ribose] polymerase 13; PARP13; Zinc finger CCCH domain-containing protein 2; Zinc finger antiviral protein; ZAP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MADPEVCCFITKILCAHGGRMALDALLQEIALSEPQLCEVLQVAGPDRFVVLETGGEAGI
TRSVVATTRARVCRRKYCQRPCDNLHLCKLNLLGRCNYSQSERNLCKYSHEVLSEENFKV
LKNHELSGLNKEELAVLLLQSDPFFMPEICKSYKGEGRQQICNQQPPCSRLHICDHFTRG
NCRFPNCLRSHNLMDRKVLAIMREHGLNPDVVQNIQDICNSKHMQKNPPGPRAPSSHRRN
MAYRARSKSRDRFFQGSQEFLASASASAERSCTPSPDQISHRASLEDAPVDDLTRKFTYL
GSQDRARPPSGSSKATDLGGTSQAGTSQRFLENGSQEDLLHGNPGSTYLASNSTSAPNWK
SLTSWTNDQGARRKTVFSPTLPAARSSLGSLQTPEAVTTRKGTGLLSSDYRIINGKSGTQ
DIQPGPLFNNNADGVATDITSTRSLNYKSTSSGHREISSPRIQDAGPASRDVQATGRIAD
DADPRVALVNDSLSDVTSTTSSRVDDHDSEEICLDHLCKGCPLNGSCSKVHFHLPYRWQM
LIGKTWTDFEHMETIEKGYCNPGIHLCSVGSYTINFRVMSCDSFPIRRLSTPSSVTKPAN
SVFTTKWIWYWKNESGTWIQYGEEKDKRKNSNVDSSYLESLYQSCPRGVVPFQAGSRNYE
LSFQGMIQTNIASKTQKDVIRRPTFVPQWYVQQMKRGPDHQPAKTSSVSLTATFRPQEDF
CFLSSKKYKLSEIHHLHPEYVRVSEHFKASMKNFKIEKIKKIENSELLDKFTWKKSQMKE
EGKLLFYATSRAYVESICSNNFDSFLHETHENKYGKGIYFAKDAIYSHKNCPYDAKNVVM
FVAQVLVGKFTEGNITYTSPPPQFDSCVDTRSNPSVFVIFQKDQVYPQYVIEYTEDKACV
IS
Target Bioclass
Other
Family
ARTD/PARP family
Subcellular location
Cytoplasm
Function
Antiviral protein which inhibits the replication of viruses by recruiting the cellular RNA degradation machineries to degrade the viral mRNAs. Binds to a ZAP-responsive element (ZRE) present in the target viral mRNA, recruits cellular poly(A)-specific ribonuclease PARN to remove the poly(A) tail, and the 3'-5' exoribonuclease complex exosome to degrade the RNA body from the 3'-end. It also recruits the decapping complex DCP1-DCP2 through RNA helicase p72 (DDX17) to remove the cap structure of the viral mRNA to initiate its degradation from the 5'-end. Its target viruses belong to families which include retroviridae: human immunodeficiency virus type 1 (HIV-1), moloney and murine leukemia virus (MoMLV) and xenotropic MuLV-related virus (XMRV), filoviridae: ebola virus (EBOV) and marburg virus (MARV), togaviridae: sindbis virus (SINV) and Ross river virus (RRV). Specifically targets the multiply spliced but not unspliced or singly spliced HIV-1 mRNAs for degradation. Isoform 1 is a more potent viral inhibitor than isoform 2. Isoform 2 acts as a positive regulator of RIGI signaling resulting in activation of the downstream effector IRF3 leading to the expression of type I IFNs and IFN stimulated genes (ISGs).
Uniprot ID
Q7Z2W4
Ensemble ID
ENST00000242351.10
HGNC ID
HGNC:23721
ChEMBL ID
CHEMBL4295879

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DU145 SNV: p.A245S DBIA    Probe Info 
HCC44 SNV: p.M751I DBIA    Probe Info 
HT115 SNV: p.V878A DBIA    Probe Info 
HT1376 Deletion: p.S594del DBIA    Probe Info 
IGR39 SNV: p.S501C DBIA    Probe Info 
JURKAT SNV: p.G415V Compound 10    Probe Info 
RKO Deletion: p.F145LfsTer49 DBIA    Probe Info 
TC71 SNV: p.V65M DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
A-EBA
 Probe Info  		3.51  LDD0215  [2]
CY-1
 Probe Info  		19.74  LDD0243  [3]
CY4
 Probe Info  		4.53  LDD0244  [3]
N1
 Probe Info  		5.71  LDD0242  [3]
W1
 Probe Info  		12.99  LDD0235  [4]
YN-1
 Probe Info  		100.00  LDD0444  [5]
STPyne
 Probe Info  		K197(5.78); K314(5.56); K374(4.19); K401(3.61)  LDD0277  [6]
BTD
 Probe Info  		C272(3.07)  LDD1699  [7]
Probe 1
 Probe Info  		Y893(12.66)  LDD3495  [8]
THZ1-DTB
 Probe Info  		C513(1.12)  LDD0460  [9]
AHL-Pu-1
 Probe Info  		C721(2.16); C518(2.17); C38(2.50)  LDD0169  [10]
HHS-475
 Probe Info  		Y690(0.57)  LDD0264  [11]
DBIA
 Probe Info  		C15(1.72); C82(2.12); C78(1.90); C88(1.90)  LDD0080  [12]
ATP probe
 Probe Info  		N.A.  LDD0199  [13]
4-Iodoacetamidophenylacetylene
 Probe Info  		C96(0.00); C219(0.00); C15(0.00); C645(0.00)  LDD0038  [14]
IA-alkyne
 Probe Info  		C272(0.00); C96(0.00); C645(0.00)  LDD0032  [15]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [16]
IPIAA_L
 Probe Info  		C645(0.00); C96(0.00); C219(0.00); C513(0.00)  LDD0031  [16]
Lodoacetamide azide
 Probe Info  		C219(0.00); C645(0.00); C174(0.00); C38(0.00)  LDD0037  [14]
JW-RF-010
 Probe Info  		C7(0.00); C645(0.00)  LDD0026  [17]
NAIA_4
 Probe Info  		C38(0.00); C106(0.00); C150(0.00); C219(0.00)  LDD2226  [18]
TFBX
 Probe Info  		N.A.  LDD0027  [17]
WYneC
 Probe Info  		N.A.  LDD0014  [19]
WYneN
 Probe Info  		C96(0.00); C272(0.00)  LDD0021  [19]
WYneO
 Probe Info  		C187(0.00); C272(0.00)  LDD0022  [19]
aHNE
 Probe Info  		N.A.  LDD0001  [19]
Compound 10
 Probe Info  		C219(0.00); C272(0.00); C645(0.00); C721(0.00)  LDD2216  [20]
Compound 11
 Probe Info  		C272(0.00); C645(0.00); C721(0.00); C96(0.00)  LDD2213  [20]
ENE
 Probe Info  		N.A.  LDD0006  [19]
IPM
 Probe Info  		C645(0.00); C518(0.00); C272(0.00)  LDD0005  [19]
VSF
 Probe Info  		N.A.  LDD0007  [19]
Phosphinate-6
 Probe Info  		C272(0.00); C721(0.00)  LDD0018  [21]
Acrolein
 Probe Info  		C219(0.00); C581(0.00)  LDD0217  [22]
Cinnamaldehyde
 Probe Info  		N.A.  LDD0220  [22]
Crotonaldehyde
 Probe Info  		C168(0.00); C272(0.00)  LDD0219  [22]
Methacrolein
 Probe Info  		C272(0.00); C174(0.00); C162(0.00); C15(0.00)  LDD0218  [22]
AOyne
 Probe Info  		11.10  LDD0443  [23]
NAIA_5
 Probe Info  		C96(0.00); C831(0.00); C150(0.00); C219(0.00)  LDD2223  [18]
PAL-AfBPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe11
 Probe Info  		6.01  LDD0472  [24]
FFF probe13
 Probe Info  		5.76  LDD0476  [24]
FFF probe3
 Probe Info  		6.80  LDD0464  [24]
VE-P
 Probe Info  		N.A.  LDD0396  [25]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C272(0.94)  LDD2142  [7]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C272(1.05)  LDD2112  [7]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C272(0.75); C15(0.57)  LDD2095  [7]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C272(1.02)  LDD2130  [7]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C174(1.05)  LDD2117  [7]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C15(1.43); C174(1.13)  LDD2152  [7]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C272(0.98)  LDD2132  [7]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C272(0.77)  LDD2131  [7]
 LDCM0026  4SU-RNA+native RNA HEK-293T C721(2.16); C518(2.17); C38(2.50)  LDD0169  [10]
 LDCM0214  AC1 HCT 116 C15(1.20); C162(1.45); C168(1.31); C174(1.42)  LDD0531  [12]
 LDCM0215  AC10 HCT 116 C15(1.10); C162(0.95); C168(0.98); C174(0.40)  LDD0532  [12]
 LDCM0216  AC100 HCT 116 C15(0.93); C162(0.66); C168(0.86); C219(0.66)  LDD0533  [12]
 LDCM0217  AC101 HCT 116 C15(0.91); C162(0.67); C168(0.85); C219(0.65)  LDD0534  [12]
 LDCM0218  AC102 HCT 116 C15(0.92); C162(0.88); C168(0.85); C219(0.65)  LDD0535  [12]
 LDCM0219  AC103 HCT 116 C15(0.84); C162(0.63); C168(1.38); C219(0.58)  LDD0536  [12]
 LDCM0220  AC104 HCT 116 C15(0.88); C162(0.99); C168(1.02); C219(0.66)  LDD0537  [12]
 LDCM0221  AC105 HCT 116 C15(0.80); C162(0.69); C168(0.86); C219(0.56)  LDD0538  [12]
 LDCM0222  AC106 HCT 116 C15(0.81); C162(0.67); C168(0.86); C219(0.65)  LDD0539  [12]
 LDCM0223  AC107 HCT 116 C15(0.76); C162(0.80); C168(1.20); C219(0.90)  LDD0540  [12]
 LDCM0224  AC108 HCT 116 C15(0.64); C162(0.59); C168(0.73); C219(0.56)  LDD0541  [12]
 LDCM0225  AC109 HCT 116 C15(0.87); C162(0.98); C168(0.99); C219(0.57)  LDD0542  [12]
 LDCM0226  AC11 HCT 116 C15(1.31); C162(0.91); C168(0.95); C174(0.54)  LDD0543  [12]
 LDCM0227  AC110 HCT 116 C15(0.66); C162(0.66); C168(0.77); C219(0.54)  LDD0544  [12]
 LDCM0228  AC111 HCT 116 C15(0.76); C162(0.63); C168(0.80); C219(0.56)  LDD0545  [12]
 LDCM0229  AC112 HCT 116 C15(0.76); C162(0.70); C168(0.92); C219(0.71)  LDD0546  [12]
 LDCM0230  AC113 HCT 116 C15(1.13); C162(1.33); C168(1.24); C219(1.12)  LDD0547  [12]
 LDCM0231  AC114 HCT 116 C15(1.05); C162(1.67); C168(1.45); C219(1.23)  LDD0548  [12]
 LDCM0232  AC115 HCT 116 C15(1.09); C162(1.23); C168(1.30); C219(0.99)  LDD0549  [12]
 LDCM0233  AC116 HCT 116 C15(1.10); C162(1.16); C168(1.30); C219(0.98)  LDD0550  [12]
 LDCM0234  AC117 HCT 116 C15(1.30); C162(1.76); C168(1.52); C219(0.99)  LDD0551  [12]
 LDCM0235  AC118 HCT 116 C15(1.17); C162(1.30); C168(1.18); C219(1.19)  LDD0552  [12]
 LDCM0236  AC119 HCT 116 C15(1.20); C162(1.38); C168(1.24); C219(1.07)  LDD0553  [12]
 LDCM0237  AC12 HCT 116 C15(1.07); C162(0.99); C168(1.02); C174(0.58)  LDD0554  [12]
 LDCM0238  AC120 HCT 116 C15(0.93); C162(1.96); C168(1.71); C219(0.99)  LDD0555  [12]
 LDCM0239  AC121 HCT 116 C15(0.99); C162(1.69); C168(1.45); C219(1.53)  LDD0556  [12]
 LDCM0240  AC122 HCT 116 C15(1.17); C162(1.28); C168(1.18); C219(1.59)  LDD0557  [12]
 LDCM0241  AC123 HCT 116 C15(1.14); C162(1.50); C168(1.30); C219(1.17)  LDD0558  [12]
 LDCM0242  AC124 HCT 116 C15(1.29); C162(1.63); C168(1.36); C219(1.36)  LDD0559  [12]
 LDCM0243  AC125 HCT 116 C15(1.07); C162(1.98); C168(1.57); C219(1.23)  LDD0560  [12]
 LDCM0244  AC126 HCT 116 C15(1.12); C162(1.52); C168(1.35); C219(1.84)  LDD0561  [12]
 LDCM0245  AC127 HCT 116 C15(1.17); C162(1.94); C168(1.60); C219(1.66)  LDD0562  [12]
 LDCM0246  AC128 HCT 116 C15(1.19); C162(0.92); C168(0.83); C219(0.89)  LDD0563  [12]
 LDCM0247  AC129 HCT 116 C15(1.09); C162(0.91); C168(0.86); C219(1.18)  LDD0564  [12]
 LDCM0249  AC130 HCT 116 C15(1.02); C162(0.76); C168(0.73); C219(0.90)  LDD0566  [12]
 LDCM0250  AC131 HCT 116 C15(1.02); C162(0.73); C168(0.75); C219(1.17)  LDD0567  [12]
 LDCM0251  AC132 HCT 116 C15(0.95); C162(0.86); C168(0.85); C219(0.99)  LDD0568  [12]
 LDCM0252  AC133 HCT 116 C15(0.94); C162(0.77); C168(0.72); C219(0.78)  LDD0569  [12]
 LDCM0253  AC134 HCT 116 C15(0.78); C162(0.68); C168(0.68); C219(0.88)  LDD0570  [12]
 LDCM0254  AC135 HCT 116 C15(0.93); C162(0.75); C168(0.70); C219(0.87)  LDD0571  [12]
 LDCM0255  AC136 HCT 116 C15(0.97); C162(0.78); C168(0.79); C219(0.89)  LDD0572  [12]
 LDCM0256  AC137 HCT 116 C15(0.89); C162(0.77); C168(0.75); C219(0.92)  LDD0573  [12]
 LDCM0257  AC138 HCT 116 C15(0.74); C162(0.66); C168(0.66); C219(0.80)  LDD0574  [12]
 LDCM0258  AC139 HCT 116 C15(0.81); C162(0.69); C168(0.68); C219(0.95)  LDD0575  [12]
 LDCM0259  AC14 HCT 116 C15(1.07); C162(1.01); C168(0.99); C174(0.43)  LDD0576  [12]
 LDCM0260  AC140 HCT 116 C15(0.80); C162(0.63); C168(0.66); C219(0.93)  LDD0577  [12]
 LDCM0261  AC141 HCT 116 C15(0.73); C162(0.79); C168(0.86); C219(0.78)  LDD0578  [12]
 LDCM0262  AC142 HCT 116 C15(1.06); C162(0.78); C168(0.76); C219(0.97)  LDD0579  [12]
 LDCM0263  AC143 HCT 116 C521(0.79); C527(0.79); C78(0.80); C219(0.81)  LDD0580  [12]
 LDCM0264  AC144 HCT 116 C521(0.54); C527(0.54); C162(0.77); C88(0.78)  LDD0581  [12]
 LDCM0265  AC145 HCT 116 C521(0.66); C527(0.66); C78(0.76); C88(0.82)  LDD0582  [12]
 LDCM0266  AC146 HCT 116 C521(0.76); C527(0.76); C78(0.85); C162(0.86)  LDD0583  [12]
 LDCM0267  AC147 HCT 116 C521(0.54); C527(0.54); C162(0.79); C78(0.82)  LDD0584  [12]
 LDCM0268  AC148 HCT 116 C521(0.71); C527(0.71); C88(0.71); C82(0.75)  LDD0585  [12]
 LDCM0269  AC149 HCT 116 C521(0.62); C527(0.62); C162(0.77); C88(0.78)  LDD0586  [12]
 LDCM0270  AC15 HCT 116 C174(0.56); C867(0.66); C88(0.84); C272(0.88)  LDD0587  [12]
 LDCM0271  AC150 HCT 116 C521(0.75); C527(0.75); C219(0.84); C96(0.86)  LDD0588  [12]
 LDCM0272  AC151 HCT 116 C162(0.79); C521(0.82); C527(0.82); C82(0.86)  LDD0589  [12]
 LDCM0273  AC152 HCT 116 C521(0.58); C527(0.58); C82(0.76); C162(0.77)  LDD0590  [12]
 LDCM0274  AC153 HCT 116 C88(0.71); C82(0.71); C521(0.75); C527(0.75)  LDD0591  [12]
 LDCM0621  AC154 HCT 116 C15(1.27); C162(0.85); C168(0.98); C219(0.90)  LDD2158  [12]
 LDCM0622  AC155 HCT 116 C15(1.07); C162(0.76); C168(0.89); C219(1.02)  LDD2159  [12]
 LDCM0623  AC156 HCT 116 C15(1.21); C162(1.00); C168(0.96); C219(1.33)  LDD2160  [12]
 LDCM0624  AC157 HCT 116 C15(1.14); C162(1.18); C168(1.15); C219(1.29)  LDD2161  [12]
 LDCM0276  AC17 HCT 116 C867(0.81); C162(0.87); C168(0.89); C82(0.94)  LDD0593  [12]
 LDCM0277  AC18 HCT 116 C867(0.54); C560(0.54); C567(0.54); C162(0.58)  LDD0594  [12]
 LDCM0278  AC19 HCT 116 C162(0.80); C82(0.85); C78(0.88); C168(0.92)  LDD0595  [12]
 LDCM0279  AC2 HCT 116 C88(0.73); C82(0.75); C78(0.76); C721(0.78)  LDD0596  [12]
 LDCM0280  AC20 HCT 116 C82(0.78); C162(0.79); C581(0.85); C168(0.88)  LDD0597  [12]
 LDCM0281  AC21 HCT 116 C82(0.83); C581(0.86); C162(0.88); C96(0.88)  LDD0598  [12]
 LDCM0282  AC22 HCT 116 C560(0.83); C567(0.83); C581(0.84); C82(0.89)  LDD0599  [12]
 LDCM0283  AC23 HCT 116 C560(0.75); C567(0.75); C78(0.77); C82(0.77)  LDD0600  [12]
 LDCM0284  AC24 HCT 116 C560(0.95); C567(0.95); C88(0.97); C581(0.99)  LDD0601  [12]
 LDCM0285  AC25 HCT 116 C560(0.70); C567(0.70); C15(0.80); C219(0.84)  LDD0602  [12]
 LDCM0286  AC26 HCT 116 C560(0.47); C567(0.47); C219(0.71); C15(0.80)  LDD0603  [12]
 LDCM0287  AC27 HCT 116 C560(0.65); C567(0.65); C219(0.66); C96(0.87)  LDD0604  [12]
 LDCM0288  AC28 HCT 116 C560(0.39); C567(0.39); C219(0.66); C96(0.71)  LDD0605  [12]
 LDCM0289  AC29 HCT 116 C560(0.42); C567(0.42); C15(0.73); C78(0.78)  LDD0606  [12]
 LDCM0290  AC3 HCT 116 C721(0.78); C88(0.84); C82(0.85); C78(0.85)  LDD0607  [12]
 LDCM0291  AC30 HCT 116 C560(0.45); C567(0.45); C96(0.69); C219(0.77)  LDD0608  [12]
 LDCM0292  AC31 HCT 116 C560(0.37); C567(0.37); C78(0.77); C96(0.80)  LDD0609  [12]
 LDCM0293  AC32 HCT 116 C560(0.32); C567(0.32); C219(0.58); C78(0.75)  LDD0610  [12]
 LDCM0294  AC33 HCT 116 C219(0.56); C96(0.76); C560(0.78); C567(0.78)  LDD0611  [12]
 LDCM0295  AC34 HCT 116 C219(0.55); C15(0.72); C78(0.74); C96(0.76)  LDD0612  [12]
 LDCM0296  AC35 HCT 116 C96(0.91); C272(0.93); C15(0.95); C645(0.96)  LDD0613  [12]
 LDCM0297  AC36 HCT 116 C15(0.91); C219(0.95); C78(0.95); C96(0.96)  LDD0614  [12]
 LDCM0298  AC37 HCT 116 C78(0.89); C15(0.95); C721(1.01); C88(1.02)  LDD0615  [12]
 LDCM0299  AC38 HCT 116 C78(0.94); C96(0.94); C82(0.94); C88(0.95)  LDD0616  [12]
 LDCM0300  AC39 HCT 116 C721(0.85); C78(0.88); C82(0.88); C88(0.91)  LDD0617  [12]
 LDCM0301  AC4 HCT 116 C78(0.76); C88(0.76); C82(0.77); C721(0.84)  LDD0618  [12]
 LDCM0302  AC40 HCT 116 C78(0.81); C82(0.89); C88(0.92); C219(0.92)  LDD0619  [12]
 LDCM0303  AC41 HCT 116 C219(0.83); C721(0.88); C78(0.89); C272(0.99)  LDD0620  [12]
 LDCM0304  AC42 HCT 116 C96(0.80); C521(0.85); C527(0.85); C78(0.88)  LDD0621  [12]
 LDCM0305  AC43 HCT 116 C78(0.81); C15(0.88); C96(0.91); C88(0.94)  LDD0622  [12]
 LDCM0306  AC44 HCT 116 C78(0.90); C721(0.95); C88(1.01); C15(1.01)  LDD0623  [12]
 LDCM0307  AC45 HCT 116 C78(0.80); C219(0.86); C88(0.90); C721(0.95)  LDD0624  [12]
 LDCM0308  AC46 HCT 116 C581(0.89); C78(0.95); C162(0.95); C88(0.96)  LDD0625  [12]
 LDCM0309  AC47 HCT 116 C581(0.86); C78(0.94); C162(0.94); C831(0.95)  LDD0626  [12]
 LDCM0310  AC48 HCT 116 C581(0.79); C78(0.88); C82(0.99); C219(1.01)  LDD0627  [12]
 LDCM0311  AC49 HCT 116 C581(0.69); C82(0.77); C78(0.78); C88(0.78)  LDD0628  [12]
 LDCM0312  AC5 HCT 116 C721(0.70); C88(0.73); C78(0.74); C82(0.74)  LDD0629  [12]
 LDCM0313  AC50 HCT 116 C78(0.83); C82(0.84); C88(0.85); C219(0.87)  LDD0630  [12]
 LDCM0314  AC51 HCT 116 C581(0.71); C15(0.83); C721(1.00); C831(1.02)  LDD0631  [12]
 LDCM0315  AC52 HCT 116 C581(0.79); C15(0.89); C831(0.89); C82(0.91)  LDD0632  [12]
 LDCM0316  AC53 HCT 116 C78(0.88); C82(0.89); C219(0.90); C88(0.91)  LDD0633  [12]
 LDCM0317  AC54 HCT 116 C219(0.83); C581(0.85); C831(0.85); C88(0.90)  LDD0634  [12]
 LDCM0318  AC55 HCT 116 C78(0.83); C219(0.85); C82(0.87); C88(0.87)  LDD0635  [12]
 LDCM0319  AC56 HCT 116 C831(0.65); C581(0.81); C219(0.82); C78(0.83)  LDD0636  [12]
 LDCM0320  AC57 HCT 116 C521(0.70); C527(0.70); C88(0.72); C78(0.73)  LDD0637  [12]
 LDCM0321  AC58 HCT 116 C88(0.62); C82(0.63); C78(0.67); C168(0.68)  LDD0638  [12]
 LDCM0322  AC59 HCT 116 C521(0.62); C527(0.62); C88(0.70); C82(0.70)  LDD0639  [12]
 LDCM0323  AC6 HCT 116 C174(0.55); C867(0.67); C82(0.76); C88(0.78)  LDD0640  [12]
 LDCM0324  AC60 HCT 116 C867(0.68); C88(0.69); C82(0.70); C78(0.74)  LDD0641  [12]
 LDCM0325  AC61 HCT 116 C78(0.68); C82(0.73); C88(0.73); C168(0.77)  LDD0642  [12]
 LDCM0326  AC62 HCT 116 C521(0.63); C527(0.63); C78(0.64); C88(0.69)  LDD0643  [12]
 LDCM0327  AC63 HCT 116 C78(0.68); C88(0.70); C82(0.70); C521(0.76)  LDD0644  [12]
 LDCM0328  AC64 HCT 116 C78(0.66); C162(0.67); C82(0.68); C88(0.69)  LDD0645  [12]
 LDCM0329  AC65 HCT 116 C162(0.57); C168(0.58); C78(0.59); C82(0.63)  LDD0646  [12]
 LDCM0330  AC66 HCT 116 C78(0.58); C162(0.59); C168(0.59); C82(0.65)  LDD0647  [12]
 LDCM0331  AC67 HCT 116 C78(0.53); C88(0.57); C82(0.58); C162(0.58)  LDD0648  [12]
 LDCM0332  AC68 HCT 116 C521(0.67); C527(0.67); C831(0.72); C581(0.79)  LDD0649  [12]
 LDCM0333  AC69 HCT 116 C867(0.75); C15(0.83); C581(0.85); C521(0.89)  LDD0650  [12]
 LDCM0334  AC7 HCT 116 C174(0.58); C867(0.77); C272(0.82); C721(0.87)  LDD0651  [12]
 LDCM0335  AC70 HCT 116 C867(0.69); C15(0.71); C581(0.75); C560(0.79)  LDD0652  [12]
 LDCM0336  AC71 HCT 116 C721(0.87); C867(0.92); C581(0.96); C272(0.99)  LDD0653  [12]
 LDCM0337  AC72 HCT 116 C560(0.71); C567(0.71); C15(0.71); C867(0.82)  LDD0654  [12]
 LDCM0338  AC73 HCT 116 C15(0.63); C521(0.70); C527(0.70); C867(0.77)  LDD0655  [12]
 LDCM0339  AC74 HCT 116 C15(0.75); C581(0.90); C521(0.91); C527(0.91)  LDD0656  [12]
 LDCM0340  AC75 HCT 116 C867(0.67); C831(0.67); C15(0.72); C560(0.77)  LDD0657  [12]
 LDCM0341  AC76 HCT 116 C581(0.82); C15(0.93); C831(0.94); C82(0.95)  LDD0658  [12]
 LDCM0342  AC77 HCT 116 C867(0.64); C15(0.69); C521(0.77); C527(0.77)  LDD0659  [12]
 LDCM0343  AC78 HCT 116 C521(0.83); C527(0.83); C867(0.85); C581(0.86)  LDD0660  [12]
 LDCM0344  AC79 HCT 116 C15(0.72); C867(0.77); C521(0.84); C527(0.84)  LDD0661  [12]
 LDCM0345  AC8 HCT 116 C174(0.58); C867(0.63); C82(0.81); C88(0.87)  LDD0662  [12]
 LDCM0346  AC80 HCT 116 C721(0.82); C831(0.93); C82(0.95); C88(0.98)  LDD0663  [12]
 LDCM0347  AC81 HCT 116 C721(0.79); C521(0.84); C527(0.84); C581(0.85)  LDD0664  [12]
 LDCM0348  AC82 HCT 116 C831(0.38); C521(0.79); C527(0.79); C82(0.90)  LDD0665  [12]
 LDCM0349  AC83 HCT 116 C174(0.41); C867(0.56); C721(0.60); C219(0.65)  LDD0666  [12]
 LDCM0350  AC84 HCT 116 C174(0.42); C867(0.59); C78(0.65); C88(0.65)  LDD0667  [12]
 LDCM0351  AC85 HCT 116 C174(0.42); C867(0.58); C88(0.63); C82(0.68)  LDD0668  [12]
 LDCM0352  AC86 HCT 116 C174(0.49); C867(0.51); C721(0.66); C78(0.68)  LDD0669  [12]
 LDCM0353  AC87 HCT 116 C867(0.61); C721(0.65); C174(0.72); C831(0.74)  LDD0670  [12]
 LDCM0354  AC88 HCT 116 C721(0.54); C174(0.56); C867(0.56); C78(0.73)  LDD0671  [12]
 LDCM0355  AC89 HCT 116 C174(0.46); C867(0.57); C78(0.62); C721(0.66)  LDD0672  [12]
 LDCM0357  AC90 HCT 116 C721(0.55); C867(0.56); C174(0.67); C831(0.69)  LDD0674  [12]
 LDCM0358  AC91 HCT 116 C174(0.46); C867(0.66); C78(0.71); C721(0.72)  LDD0675  [12]
 LDCM0359  AC92 HCT 116 C174(0.42); C867(0.56); C78(0.62); C82(0.68)  LDD0676  [12]
 LDCM0360  AC93 HCT 116 C721(0.51); C867(0.56); C174(0.56); C78(0.67)  LDD0677  [12]
 LDCM0361  AC94 HCT 116 C721(0.45); C174(0.56); C88(0.70); C78(0.72)  LDD0678  [12]
 LDCM0362  AC95 HCT 116 C174(0.68); C78(0.78); C88(0.79); C82(0.79)  LDD0679  [12]
 LDCM0363  AC96 HCT 116 C174(0.46); C721(0.58); C78(0.65); C82(0.66)  LDD0680  [12]
 LDCM0364  AC97 HCT 116 C174(0.49); C867(0.57); C78(0.61); C88(0.61)  LDD0681  [12]
 LDCM0365  AC98 HCT 116 C867(0.17); C82(0.38); C78(0.38); C88(0.41)  LDD0682  [12]
 LDCM0366  AC99 HCT 116 C88(0.50); C82(0.54); C78(0.56); C721(0.67)  LDD0683  [12]
 LDCM0545  Acetamide MDA-MB-231 C272(0.49)  LDD2138  [7]
 LDCM0520  AKOS000195272 MDA-MB-231 C15(0.94)  LDD2113  [7]
 LDCM0248  AKOS034007472 HCT 116 C15(1.27); C162(1.01); C168(0.98); C174(0.84)  LDD0565  [12]
 LDCM0356  AKOS034007680 HCT 116 C174(0.59); C867(0.72); C272(0.86); C88(0.88)  LDD0673  [12]
 LDCM0275  AKOS034007705 HCT 116 C174(0.40); C867(0.59); C88(0.68); C78(0.74)  LDD0592  [12]
 LDCM0156  Aniline NCI-H1299 C645(0.00); C272(0.00)  LDD0404  [1]
 LDCM0020  ARS-1620 HCC44 C15(2.94); C162(1.32); C168(1.32); C78(1.22)  LDD2171  [12]
 LDCM0498  BS-3668 MDA-MB-231 C272(0.60)  LDD2091  [7]
 LDCM0630  CCW28-3 231MFP C645(1.49); C38(1.40); C272(1.19)  LDD2214  [26]
 LDCM0108  Chloroacetamide HeLa C645(0.00); C798(0.00); C581(0.00); C15(0.00)  LDD0222  [22]
 LDCM0632  CL-Sc Hep-G2 C15(20.00); C272(20.00); C96(2.49); C721(0.86)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C867(0.79); C174(0.93); C88(0.95); C96(0.95)  LDD0684  [12]
 LDCM0368  CL10 HCT 116 C867(0.61); C174(0.65); C78(0.70); C96(0.87)  LDD0685  [12]
 LDCM0369  CL100 HCT 116 C88(0.70); C82(0.71); C78(0.74); C721(0.85)  LDD0686  [12]
 LDCM0370  CL101 HCT 116 C174(0.53); C88(0.73); C867(0.73); C78(0.76)  LDD0687  [12]
 LDCM0371  CL102 HCT 116 C174(0.58); C867(0.59); C272(0.76); C88(0.79)  LDD0688  [12]
 LDCM0372  CL103 HCT 116 C174(0.51); C867(0.73); C272(0.89); C645(0.95)  LDD0689  [12]
 LDCM0373  CL104 HCT 116 C174(0.53); C867(0.68); C272(0.84); C521(0.84)  LDD0690  [12]
 LDCM0374  CL105 HCT 116 C560(0.59); C567(0.59); C581(0.63); C162(0.68)  LDD0691  [12]
 LDCM0375  CL106 HCT 116 C162(0.62); C219(0.64); C560(0.68); C567(0.68)  LDD0692  [12]
 LDCM0376  CL107 HCT 116 C581(0.55); C560(0.57); C567(0.57); C162(0.60)  LDD0693  [12]
 LDCM0377  CL108 HCT 116 C581(0.58); C560(0.63); C567(0.63); C162(0.66)  LDD0694  [12]
 LDCM0378  CL109 HCT 116 C162(0.66); C581(0.69); C560(0.73); C567(0.73)  LDD0695  [12]
 LDCM0379  CL11 HCT 116 C174(0.69); C78(0.70); C82(0.87); C162(0.87)  LDD0696  [12]
 LDCM0380  CL110 HCT 116 C162(0.58); C168(0.69); C219(0.71); C581(0.75)  LDD0697  [12]
 LDCM0381  CL111 HCT 116 C162(0.71); C96(0.72); C581(0.73); C168(0.74)  LDD0698  [12]
 LDCM0382  CL112 HCT 116 C560(0.64); C567(0.64); C96(0.74); C15(0.74)  LDD0699  [12]
 LDCM0383  CL113 HCT 116 C560(0.46); C567(0.46); C219(0.60); C78(0.69)  LDD0700  [12]
 LDCM0384  CL114 HCT 116 C219(0.63); C15(0.69); C560(0.70); C567(0.70)  LDD0701  [12]
 LDCM0385  CL115 HCT 116 C560(0.64); C567(0.64); C219(0.68); C15(0.75)  LDD0702  [12]
 LDCM0386  CL116 HCT 116 C560(0.53); C567(0.53); C219(0.68); C96(0.74)  LDD0703  [12]
 LDCM0387  CL117 HCT 116 C78(0.78); C88(0.82); C82(0.83); C96(0.84)  LDD0704  [12]
 LDCM0388  CL118 HCT 116 C78(0.90); C15(0.91); C162(0.91); C96(0.93)  LDD0705  [12]
 LDCM0389  CL119 HCT 116 C78(0.84); C15(0.93); C88(0.93); C96(0.98)  LDD0706  [12]
 LDCM0390  CL12 HCT 116 C174(0.78); C78(0.89); C867(0.96); C15(0.97)  LDD0707  [12]
 LDCM0391  CL120 HCT 116 C78(0.88); C15(0.90); C721(0.96); C88(1.02)  LDD0708  [12]
 LDCM0392  CL121 HCT 116 C831(0.47); C219(0.76); C96(0.83); C645(0.83)  LDD0709  [12]
 LDCM0393  CL122 HCT 116 C219(0.76); C581(0.81); C78(0.81); C88(0.81)  LDD0710  [12]
 LDCM0394  CL123 HCT 116 C78(0.81); C82(0.84); C88(0.84); C581(0.85)  LDD0711  [12]
 LDCM0395  CL124 HCT 116 C82(0.82); C581(0.83); C219(0.83); C88(0.84)  LDD0712  [12]
 LDCM0396  CL125 HCT 116 C78(0.78); C82(0.84); C88(0.86); C168(0.94)  LDD0713  [12]
 LDCM0397  CL126 HCT 116 C15(0.76); C82(0.76); C88(0.77); C168(0.78)  LDD0714  [12]
 LDCM0398  CL127 HCT 116 C831(0.77); C78(0.78); C88(0.80); C82(0.81)  LDD0715  [12]
 LDCM0399  CL128 HCT 116 C521(0.64); C527(0.64); C78(0.71); C168(0.72)  LDD0716  [12]
 LDCM0400  CL13 HCT 116 C174(0.73); C867(0.74); C78(0.75); C96(0.87)  LDD0717  [12]
 LDCM0401  CL14 HCT 116 C174(0.82); C78(0.82); C867(0.85); C88(0.97)  LDD0718  [12]
 LDCM0402  CL15 HCT 116 C867(0.61); C162(0.77); C174(0.82); C96(0.84)  LDD0719  [12]
 LDCM0403  CL16 HCT 116 C867(0.89); C96(0.90); C645(0.98); C721(1.01)  LDD0720  [12]
 LDCM0404  CL17 HCT 116 C867(0.67); C96(0.81); C174(0.88); C15(0.88)  LDD0721  [12]
 LDCM0405  CL18 HCT 116 C867(0.84); C521(0.94); C527(0.94); C88(0.97)  LDD0722  [12]
 LDCM0406  CL19 HCT 116 C867(0.68); C721(0.77); C78(0.86); C82(0.88)  LDD0723  [12]
 LDCM0407  CL2 HCT 116 C78(0.97); C867(0.98); C82(1.00); C88(1.00)  LDD0724  [12]
 LDCM0408  CL20 HCT 116 C867(0.66); C174(0.73); C82(0.88); C88(0.90)  LDD0725  [12]
 LDCM0409  CL21 HCT 116 C174(0.59); C867(0.60); C82(0.79); C162(0.82)  LDD0726  [12]
 LDCM0410  CL22 HCT 116 C867(0.60); C174(0.70); C82(0.81); C78(0.82)  LDD0727  [12]
 LDCM0411  CL23 HCT 116 C867(0.85); C521(0.91); C527(0.91); C82(0.94)  LDD0728  [12]
 LDCM0412  CL24 HCT 116 C15(1.03); C162(1.02); C168(1.00); C174(0.75)  LDD0729  [12]
 LDCM0413  CL25 HCT 116 C15(1.07); C162(1.15); C168(1.04); C174(0.74)  LDD0730  [12]
 LDCM0414  CL26 HCT 116 C15(1.24); C162(0.93); C168(1.04); C174(0.79)  LDD0731  [12]
 LDCM0415  CL27 HCT 116 C15(1.14); C162(1.00); C168(1.00); C174(0.73)  LDD0732  [12]
 LDCM0416  CL28 HCT 116 C15(1.12); C162(0.97); C168(0.89); C174(0.86)  LDD0733  [12]
 LDCM0417  CL29 HCT 116 C15(1.06); C162(0.88); C168(0.96); C174(0.68)  LDD0734  [12]
 LDCM0418  CL3 HCT 116 C15(1.03); C162(1.11); C168(1.10); C174(0.91)  LDD0735  [12]
 LDCM0419  CL30 HCT 116 C15(0.87); C162(1.72); C168(2.14); C174(1.14)  LDD0736  [12]
 LDCM0420  CL31 HCT 116 C15(0.90); C162(0.95); C168(1.49); C174(0.69)  LDD0737  [12]
 LDCM0421  CL32 HCT 116 C15(0.95); C162(0.74); C168(1.33); C174(0.82)  LDD0738  [12]
 LDCM0422  CL33 HCT 116 C15(0.82); C162(0.75); C168(1.44); C174(0.68)  LDD0739  [12]
 LDCM0423  CL34 HCT 116 C15(0.85); C162(0.87); C168(1.19); C174(2.58)  LDD0740  [12]
 LDCM0424  CL35 HCT 116 C15(1.08); C162(0.73); C168(1.15); C174(0.85)  LDD0741  [12]
 LDCM0425  CL36 HCT 116 C15(0.80); C162(0.70); C168(1.75); C174(0.58)  LDD0742  [12]
 LDCM0426  CL37 HCT 116 C15(0.87); C162(0.78); C168(1.34); C174(0.74)  LDD0743  [12]
 LDCM0428  CL39 HCT 116 C15(0.96); C162(0.75); C168(1.23); C174(0.76)  LDD0745  [12]
 LDCM0429  CL4 HCT 116 C15(0.92); C162(0.76); C168(1.06); C174(0.98)  LDD0746  [12]
 LDCM0430  CL40 HCT 116 C15(0.72); C162(0.63); C168(1.50); C174(0.57)  LDD0747  [12]
 LDCM0431  CL41 HCT 116 C15(0.78); C162(0.74); C168(1.59); C174(0.93)  LDD0748  [12]
 LDCM0432  CL42 HCT 116 C15(0.76); C162(0.77); C168(1.27); C174(0.76)  LDD0749  [12]
 LDCM0433  CL43 HCT 116 C15(0.83); C162(0.70); C168(1.67); C174(0.77)  LDD0750  [12]
 LDCM0434  CL44 HCT 116 C15(0.98); C162(0.83); C168(1.28); C174(0.96)  LDD0751  [12]
 LDCM0435  CL45 HCT 116 C15(1.02); C162(0.85); C168(1.23); C174(0.53)  LDD0752  [12]
 LDCM0436  CL46 HCT 116 C15(1.04); C162(1.11); C168(1.09); C272(0.93)  LDD0753  [12]
 LDCM0437  CL47 HCT 116 C15(1.00); C162(1.33); C168(1.39); C272(0.95)  LDD0754  [12]
 LDCM0438  CL48 HCT 116 C15(1.00); C162(1.42); C168(1.42); C272(0.96)  LDD0755  [12]
 LDCM0439  CL49 HCT 116 C15(1.13); C162(1.16); C168(1.22); C272(0.80)  LDD0756  [12]
 LDCM0440  CL5 HCT 116 C15(1.24); C162(1.36); C168(1.25); C174(0.92)  LDD0757  [12]
 LDCM0441  CL50 HCT 116 C15(1.09); C162(1.19); C168(1.19); C272(0.81)  LDD0758  [12]
 LDCM0442  CL51 HCT 116 C15(1.08); C162(1.13); C168(1.12); C272(0.86)  LDD0759  [12]
 LDCM0443  CL52 HCT 116 C15(0.95); C162(1.35); C168(1.35); C272(0.94)  LDD0760  [12]
 LDCM0444  CL53 HCT 116 C15(0.79); C162(1.08); C168(1.15); C272(1.37)  LDD0761  [12]
 LDCM0445  CL54 HCT 116 C15(0.91); C162(1.29); C168(1.22); C272(0.90)  LDD0762  [12]
 LDCM0446  CL55 HCT 116 C15(1.02); C162(1.53); C168(1.57); C272(0.91)  LDD0763  [12]
 LDCM0447  CL56 HCT 116 C15(0.98); C162(1.17); C168(1.18); C272(0.96)  LDD0764  [12]
 LDCM0448  CL57 HCT 116 C15(1.01); C162(1.15); C168(1.29); C272(0.99)  LDD0765  [12]
 LDCM0449  CL58 HCT 116 C15(0.96); C162(1.53); C168(1.36); C272(0.94)  LDD0766  [12]
 LDCM0450  CL59 HCT 116 C15(1.00); C162(1.23); C168(1.28); C272(0.87)  LDD0767  [12]
 LDCM0451  CL6 HCT 116 C15(1.05); C162(1.05); C168(1.16); C174(0.90)  LDD0768  [12]
 LDCM0452  CL60 HCT 116 C15(1.07); C162(1.14); C168(1.21); C272(0.97)  LDD0769  [12]
 LDCM0453  CL61 HCT 116 C15(1.01); C162(1.08); C168(1.11); C272(1.07)  LDD0770  [12]
 LDCM0454  CL62 HCT 116 C15(0.99); C162(1.14); C168(1.07); C272(0.87)  LDD0771  [12]
 LDCM0455  CL63 HCT 116 C15(0.93); C162(0.78); C168(0.98); C272(0.99)  LDD0772  [12]
 LDCM0456  CL64 HCT 116 C15(1.00); C162(0.96); C168(1.07); C272(0.95)  LDD0773  [12]
 LDCM0457  CL65 HCT 116 C15(0.99); C162(0.96); C168(1.09); C272(0.83)  LDD0774  [12]
 LDCM0458  CL66 HCT 116 C15(1.09); C162(0.90); C168(1.02); C272(0.80)  LDD0775  [12]
 LDCM0459  CL67 HCT 116 C15(0.99); C162(0.79); C168(1.05); C272(1.10)  LDD0776  [12]
 LDCM0460  CL68 HCT 116 C15(0.93); C162(0.89); C168(1.06); C272(1.03)  LDD0777  [12]
 LDCM0461  CL69 HCT 116 C15(0.96); C162(0.97); C168(1.05); C272(0.85)  LDD0778  [12]
 LDCM0462  CL7 HCT 116 C15(1.25); C162(1.18); C168(1.58); C174(0.85)  LDD0779  [12]
 LDCM0463  CL70 HCT 116 C15(0.81); C162(0.97); C168(1.02); C272(1.02)  LDD0780  [12]
 LDCM0464  CL71 HCT 116 C15(0.88); C162(1.02); C168(1.06); C272(0.97)  LDD0781  [12]
 LDCM0465  CL72 HCT 116 C15(0.94); C162(0.90); C168(1.06); C272(0.97)  LDD0782  [12]
 LDCM0466  CL73 HCT 116 C15(0.87); C162(1.00); C168(1.01); C272(1.02)  LDD0783  [12]
 LDCM0467  CL74 HCT 116 C15(0.87); C162(0.83); C168(0.99); C272(1.02)  LDD0784  [12]
 LDCM0469  CL76 HCT 116 C15(0.93); C162(0.91); C168(0.92); C219(0.72)  LDD0786  [12]
 LDCM0470  CL77 HCT 116 C15(0.84); C162(0.82); C168(0.81); C219(0.72)  LDD0787  [12]
 LDCM0471  CL78 HCT 116 C15(0.80); C162(0.82); C168(0.81); C219(0.71)  LDD0788  [12]
 LDCM0472  CL79 HCT 116 C15(0.87); C162(0.82); C168(0.84); C219(0.65)  LDD0789  [12]
 LDCM0473  CL8 HCT 116 C15(0.98); C162(1.08); C168(1.36); C174(0.75)  LDD0790  [12]
 LDCM0474  CL80 HCT 116 C15(1.01); C162(1.02); C168(0.99); C219(0.81)  LDD0791  [12]
 LDCM0475  CL81 HCT 116 C15(0.87); C162(0.90); C168(0.89); C219(0.66)  LDD0792  [12]
 LDCM0476  CL82 HCT 116 C15(0.98); C162(0.80); C168(0.77); C219(0.69)  LDD0793  [12]
 LDCM0477  CL83 HCT 116 C15(0.87); C162(0.75); C168(0.75); C219(0.56)  LDD0794  [12]
 LDCM0478  CL84 HCT 116 C15(0.89); C162(0.74); C168(0.73); C219(0.54)  LDD0795  [12]
 LDCM0479  CL85 HCT 116 C15(0.89); C162(0.84); C168(0.84); C219(0.65)  LDD0796  [12]
 LDCM0480  CL86 HCT 116 C15(0.98); C162(0.90); C168(0.88); C219(0.87)  LDD0797  [12]
 LDCM0481  CL87 HCT 116 C15(0.92); C162(0.86); C168(0.84); C219(0.54)  LDD0798  [12]
 LDCM0482  CL88 HCT 116 C15(0.96); C162(0.79); C168(0.77); C219(0.61)  LDD0799  [12]
 LDCM0483  CL89 HCT 116 C15(0.91); C162(0.73); C168(0.70); C219(0.52)  LDD0800  [12]
 LDCM0484  CL9 HCT 116 C15(1.13); C162(0.97); C168(1.09); C174(0.87)  LDD0801  [12]
 LDCM0485  CL90 HCT 116 C15(0.80); C162(0.69); C168(0.70); C219(0.78)  LDD0802  [12]
 LDCM0486  CL91 HCT 116 C15(0.92); C162(1.05); C168(1.00); C174(0.71)  LDD0803  [12]
 LDCM0487  CL92 HCT 116 C15(0.89); C162(1.18); C168(1.09); C174(0.81)  LDD0804  [12]
 LDCM0488  CL93 HCT 116 C15(1.00); C162(1.33); C168(1.21); C174(0.95)  LDD0805  [12]
 LDCM0489  CL94 HCT 116 C15(1.03); C162(1.24); C168(1.15); C174(0.83)  LDD0806  [12]
 LDCM0490  CL95 HCT 116 C15(0.88); C162(0.98); C168(0.94); C174(0.81)  LDD0807  [12]
 LDCM0491  CL96 HCT 116 C15(1.03); C162(1.17); C168(1.12); C174(0.80)  LDD0808  [12]
 LDCM0492  CL97 HCT 116 C15(1.03); C162(0.99); C168(1.01); C174(0.72)  LDD0809  [12]
 LDCM0493  CL98 HCT 116 C15(1.04); C162(1.13); C168(1.16); C174(0.87)  LDD0810  [12]
 LDCM0494  CL99 HCT 116 C15(1.09); C162(1.33); C168(1.29); C174(2.07)  LDD0811  [12]
 LDCM0495  E2913 HEK-293T C96(1.00); C272(0.88); C15(0.97); C174(1.17)  LDD1698  [27]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C581(1.64); C168(1.50); C82(1.24); C174(1.20)  LDD1702  [7]
 LDCM0625  F8 Ramos C96(1.38); C15(0.81); C645(1.02); C219(0.94)  LDD2187  [28]
 LDCM0572  Fragment10 MDA-MB-231 C645(3.84)  LDD1465  [29]
 LDCM0573  Fragment11 MDA-MB-231 C645(1.04)  LDD1467  [29]
 LDCM0574  Fragment12 MDA-MB-231 C645(3.31)  LDD1468  [29]
 LDCM0575  Fragment13 MDA-MB-231 C645(1.29)  LDD1469  [29]
 LDCM0576  Fragment14 MDA-MB-231 C645(1.37)  LDD1471  [29]
 LDCM0579  Fragment20 Ramos C96(0.47); C15(0.39); C645(0.70); C219(0.70)  LDD2194  [28]
 LDCM0580  Fragment21 MDA-MB-231 C645(0.89)  LDD1473  [29]
 LDCM0582  Fragment23 Ramos C96(0.78); C15(1.43); C645(0.85); C219(1.07)  LDD2196  [28]
 LDCM0578  Fragment27 MDA-MB-231 C645(0.82)  LDD1474  [29]
 LDCM0586  Fragment28 Ramos C96(0.54); C15(0.31); C645(1.21); C219(3.22)  LDD2198  [28]
 LDCM0587  Fragment29 Ramos C645(1.63)  LDD1476  [29]
 LDCM0588  Fragment30 Ramos C96(1.20); C15(1.59); C645(1.08); C219(0.82)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C96(1.05); C15(1.27); C645(0.93); C219(0.91)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C96(0.45); C15(0.52); C645(1.60); C219(0.51)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C15(0.97); C162(1.44); C168(1.34); C272(0.98)  LDD0785  [12]
 LDCM0596  Fragment38 MDA-MB-231 C645(0.86)  LDD1480  [29]
 LDCM0566  Fragment4 MDA-MB-231 C645(4.35)  LDD1461  [29]
 LDCM0599  Fragment41 MDA-MB-231 C645(0.86)  LDD1481  [29]
 LDCM0603  Fragment45 MDA-MB-231 C645(4.59)  LDD1482  [29]
 LDCM0427  Fragment51 HCT 116 C15(0.81); C162(0.59); C168(1.60); C174(0.58)  LDD0744  [12]
 LDCM0610  Fragment52 Ramos C96(1.45); C15(1.99); C645(0.87); C219(0.93)  LDD2204  [28]
 LDCM0614  Fragment56 MDA-MB-231 C645(0.91)  LDD1484  [29]
 LDCM0569  Fragment7 Ramos C96(0.53); C15(0.31); C645(1.05); C219(0.67)  LDD2186  [28]
 LDCM0570  Fragment8 MDA-MB-231 C645(5.11)  LDD1462  [29]
 LDCM0571  Fragment9 MDA-MB-231 C645(3.04)  LDD1463  [29]
 LDCM0116  HHS-0101 DM93 Y690(0.57)  LDD0264  [11]
 LDCM0117  HHS-0201 DM93 Y690(0.30)  LDD0265  [11]
 LDCM0118  HHS-0301 DM93 Y690(0.34)  LDD0266  [11]
 LDCM0119  HHS-0401 DM93 Y690(2.12)  LDD0267  [11]
 LDCM0120  HHS-0701 DM93 Y690(1.01)  LDD0268  [11]
 LDCM0107  IAA HeLa H110(0.00); C581(0.00); H531(0.00); H176(0.00)  LDD0221  [22]
 LDCM0022  KB02 HCT 116 C15(1.72); C82(2.12); C78(1.90); C88(1.90)  LDD0080  [12]
 LDCM0023  KB03 HCT 116 C15(4.09); C82(5.41); C78(5.86); C88(5.86)  LDD0081  [12]
 LDCM0024  KB05 HCT 116 C15(2.40); C82(2.19); C78(2.18); C88(2.18)  LDD0082  [12]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C272(0.90)  LDD2102  [7]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C272(0.74); C15(0.89)  LDD2121  [7]
 LDCM0109  NEM HeLa H110(0.00); H533(0.00)  LDD0223  [22]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C15(0.55)  LDD2089  [7]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C272(0.86)  LDD2092  [7]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C272(1.32); C15(1.31)  LDD2093  [7]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C272(1.03)  LDD2094  [7]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C272(0.61)  LDD2096  [7]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C272(1.44); C15(0.92)  LDD2097  [7]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C272(0.93)  LDD2098  [7]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C272(0.83); C15(1.19); C174(1.13)  LDD2099  [7]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C272(0.95); C15(0.65)  LDD2100  [7]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C272(0.98); C15(1.01)  LDD2101  [7]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C272(0.89); C15(0.41)  LDD2104  [7]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C272(1.33)  LDD2105  [7]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C272(0.73)  LDD2106  [7]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C272(0.89); C15(1.01); C174(1.15); C187(1.66)  LDD2107  [7]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C15(0.78)  LDD2108  [7]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C272(0.92); C15(0.62)  LDD2109  [7]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C272(1.68); C15(0.66)  LDD2110  [7]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C272(1.22); C15(1.07); C174(1.07)  LDD2111  [7]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C272(0.79)  LDD2114  [7]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C272(0.90); C15(0.42)  LDD2115  [7]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C272(0.88)  LDD2118  [7]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C272(2.47); C174(1.00)  LDD2119  [7]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C272(0.80)  LDD2120  [7]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C272(0.94)  LDD2122  [7]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C272(0.84); C15(0.97); C174(1.01)  LDD2123  [7]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C272(0.84)  LDD2124  [7]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C272(1.06); C15(0.70); C174(0.93)  LDD2125  [7]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C272(0.81)  LDD2126  [7]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C15(1.10); C174(1.39); C187(0.94)  LDD2127  [7]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C272(0.83); C15(0.46)  LDD2128  [7]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C272(0.94); C15(1.31); C174(1.40); C187(1.30)  LDD2129  [7]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C272(0.73)  LDD2133  [7]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C272(0.70); C15(0.64)  LDD2134  [7]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C272(0.86); C15(1.48); C174(1.93)  LDD2135  [7]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C15(1.22); C174(1.37); C187(1.01); C219(1.09)  LDD2136  [7]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C272(0.93); C15(0.91); C174(0.78)  LDD2137  [7]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C15(2.67)  LDD1700  [7]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C272(0.90); C15(0.85); C174(1.01); C187(1.32)  LDD2140  [7]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C272(0.86); C15(0.94)  LDD2141  [7]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C272(1.08); C15(0.52)  LDD2143  [7]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C272(3.22); C15(2.02); C174(1.67)  LDD2144  [7]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C272(0.90); C15(1.02); C174(1.31)  LDD2146  [7]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C272(2.45); C15(0.47)  LDD2147  [7]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C272(0.76); C15(0.50)  LDD2148  [7]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C272(0.87)  LDD2149  [7]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C272(0.41); C15(0.41)  LDD2150  [7]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C272(1.04)  LDD2151  [7]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C272(1.77)  LDD2153  [7]
 LDCM0627  NUDT7-COV-1 HEK-293T C272(1.15)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C645(0.80); C272(0.77)  LDD2207  [30]
 LDCM0131  RA190 MM1.R C645(1.49)  LDD0304  [31]
 LDCM0170  Structure8 Ramos 5.88  LDD0433  [32]
 LDCM0021  THZ1 HeLa S3 C513(1.12)  LDD0460  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Antiviral innate immune response receptor RIG-I (RIGI) Helicase family O95786
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
MyoD family inhibitor (MDFI) MDFI family Q99750
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Keratin-associated protein 10-6 (KRTAP10-6) KRTAP type 10 family P60371

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
3 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
4 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
5 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
6 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
7 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
8 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
9 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
10 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
11 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
12 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
13 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
14 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
15 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
16 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
21 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
22 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
23 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
24 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
25 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
26 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
27 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
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