Details of the Target

General Information of Target

Target ID LDTP16095
Target Name Ethylmalonyl-CoA decarboxylase (ECHDC1)
Gene Name ECHDC1
Gene ID 55862
Synonyms
Ethylmalonyl-CoA decarboxylase; EC 4.1.1.94; Enoyl-CoA hydratase domain-containing protein 1; Methylmalonyl-CoA decarboxylase; MMCD
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGSGRRALSAVPAVLLVLTLPGLPVWAQNDTEPIVLEGKCLVVCDSNPATDSKGSSSSPL
GISVRAANSKVAFSAVRSTNHEPSEMSNKTRIIYFDQILVNVGNFFTLESVFVAPRKGIY
SFSFHVIKVYQSQTIQVNLMLNGKPVISAFAGDKDVTREAATNGVLLYLDKEDKVYLKLE
KGNLVGGWQYSTFSGFLVFPL
Target Bioclass
Enzyme
Family
Enoyl-CoA hydratase/isomerase family
Subcellular location
Cytoplasm, cytosol
Function
Decarboxylates ethylmalonyl-CoA, a potentially toxic metabolite, to form butyryl-CoA, suggesting it might be involved in metabolite proofreading. Acts preferentially on (S)-ethylmalonyl-CoA but has also some activity on the (R)-isomer. Also has methylmalonyl-CoA decarboxylase activity at lower level.
Uniprot ID
Q9NTX5
Ensemble ID
ENST00000368289.6
HGNC ID
HGNC:21489

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 18 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
TH216
 Probe Info  		Y274(20.00)  LDD0259  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
STPyne
 Probe Info  		K13(10.00); K179(5.45); K217(8.33)  LDD0277  [4]
YY4-yne
 Probe Info  		3.17  LDD0400  [5]
DBIA
 Probe Info  		C133(0.63)  LDD0531  [6]
ATP probe
 Probe Info  		K179(0.00); K217(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		N.A.  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0036  [8]
Lodoacetamide azide
 Probe Info  		C268(0.00); C133(0.00)  LDD0037  [8]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [9]
IPM
 Probe Info  		N.A.  LDD0005  [10]
NHS
 Probe Info  		N.A.  LDD0010  [10]
TFBX
 Probe Info  		N.A.  LDD0148  [9]
Phosphinate-6
 Probe Info  		N.A.  LDD0018  [11]
Ox-W18
 Probe Info  		W96(0.00); W248(0.00)  LDD2175  [12]
AOyne
 Probe Info  		15.00  LDD0443  [13]
TER-AC
 Probe Info  		N.A.  LDD0426  [14]
PAL-AfBPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C170
 Probe Info  		7.78  LDD1850  [15]
FFF probe11
 Probe Info  		10.56  LDD0471  [16]
FFF probe13
 Probe Info  		20.00  LDD0475  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C133(20.00)  LDD0371  [17]
 LDCM0214  AC1 HCT 116 C133(0.63)  LDD0531  [6]
 LDCM0215  AC10 HEK-293T C133(1.13)  LDD1508  [18]
 LDCM0216  AC100 HCT 116 C133(1.22)  LDD0533  [6]
 LDCM0217  AC101 HCT 116 C133(1.15)  LDD0534  [6]
 LDCM0218  AC102 HCT 116 C133(1.32)  LDD0535  [6]
 LDCM0219  AC103 HCT 116 C133(1.51)  LDD0536  [6]
 LDCM0220  AC104 HCT 116 C133(1.34)  LDD0537  [6]
 LDCM0221  AC105 HCT 116 C133(1.16)  LDD0538  [6]
 LDCM0222  AC106 HCT 116 C133(1.83)  LDD0539  [6]
 LDCM0223  AC107 HCT 116 C133(1.22)  LDD0540  [6]
 LDCM0224  AC108 HCT 116 C133(1.28)  LDD0541  [6]
 LDCM0225  AC109 HCT 116 C133(1.44)  LDD0542  [6]
 LDCM0226  AC11 HEK-293T C133(1.02)  LDD1509  [18]
 LDCM0227  AC110 HCT 116 C133(1.57)  LDD0544  [6]
 LDCM0228  AC111 HCT 116 C133(1.50)  LDD0545  [6]
 LDCM0229  AC112 HCT 116 C133(1.39)  LDD0546  [6]
 LDCM0230  AC113 HCT 116 C133(0.70)  LDD0547  [6]
 LDCM0231  AC114 HCT 116 C133(1.12)  LDD0548  [6]
 LDCM0232  AC115 HCT 116 C133(0.98)  LDD0549  [6]
 LDCM0233  AC116 HCT 116 C133(1.09)  LDD0550  [6]
 LDCM0234  AC117 HCT 116 C133(1.16)  LDD0551  [6]
 LDCM0235  AC118 HCT 116 C133(1.02)  LDD0552  [6]
 LDCM0236  AC119 HCT 116 C133(1.11)  LDD0553  [6]
 LDCM0237  AC12 HEK-293T C133(1.08)  LDD1510  [18]
 LDCM0238  AC120 HCT 116 C133(0.87)  LDD0555  [6]
 LDCM0239  AC121 HCT 116 C133(1.51)  LDD0556  [6]
 LDCM0240  AC122 HCT 116 C133(0.81)  LDD0557  [6]
 LDCM0241  AC123 HCT 116 C133(1.08)  LDD0558  [6]
 LDCM0242  AC124 HCT 116 C133(1.30)  LDD0559  [6]
 LDCM0243  AC125 HCT 116 C133(1.41)  LDD0560  [6]
 LDCM0244  AC126 HCT 116 C133(1.41)  LDD0561  [6]
 LDCM0245  AC127 HCT 116 C133(1.68)  LDD0562  [6]
 LDCM0246  AC128 PaTu 8988t C133(0.48)  LDD1125  [6]
 LDCM0247  AC129 PaTu 8988t C133(0.60)  LDD1126  [6]
 LDCM0249  AC130 PaTu 8988t C133(0.63)  LDD1128  [6]
 LDCM0250  AC131 PaTu 8988t C133(0.99)  LDD1129  [6]
 LDCM0251  AC132 PaTu 8988t C133(1.01)  LDD1130  [6]
 LDCM0252  AC133 PaTu 8988t C133(0.71)  LDD1131  [6]
 LDCM0253  AC134 PaTu 8988t C133(0.71)  LDD1132  [6]
 LDCM0254  AC135 PaTu 8988t C133(0.68)  LDD1133  [6]
 LDCM0255  AC136 PaTu 8988t C133(0.47)  LDD1134  [6]
 LDCM0256  AC137 PaTu 8988t C133(0.58)  LDD1135  [6]
 LDCM0257  AC138 PaTu 8988t C133(0.55)  LDD1136  [6]
 LDCM0258  AC139 PaTu 8988t C133(0.47)  LDD1137  [6]
 LDCM0259  AC14 HEK-293T C133(0.98)  LDD1512  [18]
 LDCM0260  AC140 PaTu 8988t C133(0.62)  LDD1139  [6]
 LDCM0261  AC141 PaTu 8988t C133(0.84)  LDD1140  [6]
 LDCM0262  AC142 PaTu 8988t C133(0.58)  LDD1141  [6]
 LDCM0270  AC15 HEK-293T C133(0.91)  LDD1513  [18]
 LDCM0276  AC17 PaTu 8988t C133(1.37)  LDD1155  [6]
 LDCM0277  AC18 PaTu 8988t C133(1.19)  LDD1156  [6]
 LDCM0278  AC19 PaTu 8988t C133(1.09)  LDD1157  [6]
 LDCM0279  AC2 HCT 116 C133(0.65)  LDD0596  [6]
 LDCM0280  AC20 PaTu 8988t C133(1.21)  LDD1159  [6]
 LDCM0281  AC21 PaTu 8988t C133(1.13)  LDD1160  [6]
 LDCM0282  AC22 PaTu 8988t C133(1.42)  LDD1161  [6]
 LDCM0283  AC23 PaTu 8988t C133(1.07)  LDD1162  [6]
 LDCM0284  AC24 PaTu 8988t C133(0.77)  LDD1163  [6]
 LDCM0285  AC25 HEK-293T C133(1.01)  LDD1524  [18]
 LDCM0286  AC26 HEK-293T C133(1.02)  LDD1525  [18]
 LDCM0287  AC27 HEK-293T C133(1.05)  LDD1526  [18]
 LDCM0288  AC28 HEK-293T C133(0.93)  LDD1527  [18]
 LDCM0289  AC29 HEK-293T C133(1.04)  LDD1528  [18]
 LDCM0290  AC3 HCT 116 C133(0.57)  LDD0607  [6]
 LDCM0291  AC30 HEK-293T C133(0.92)  LDD1530  [18]
 LDCM0292  AC31 HEK-293T C133(1.00)  LDD1531  [18]
 LDCM0293  AC32 HEK-293T C133(1.10)  LDD1532  [18]
 LDCM0294  AC33 HEK-293T C133(1.02)  LDD1533  [18]
 LDCM0295  AC34 HEK-293T C133(0.92)  LDD1534  [18]
 LDCM0296  AC35 PaTu 8988t C133(0.91)  LDD1175  [6]
 LDCM0297  AC36 PaTu 8988t C133(1.07)  LDD1176  [6]
 LDCM0298  AC37 PaTu 8988t C133(1.43)  LDD1177  [6]
 LDCM0299  AC38 PaTu 8988t C133(1.31)  LDD1178  [6]
 LDCM0300  AC39 PaTu 8988t C133(1.37)  LDD1179  [6]
 LDCM0301  AC4 HCT 116 C133(0.52)  LDD0618  [6]
 LDCM0302  AC40 PaTu 8988t C133(1.24)  LDD1181  [6]
 LDCM0303  AC41 PaTu 8988t C133(1.22)  LDD1182  [6]
 LDCM0304  AC42 PaTu 8988t C133(1.10)  LDD1183  [6]
 LDCM0305  AC43 PaTu 8988t C133(1.78)  LDD1184  [6]
 LDCM0306  AC44 PaTu 8988t C133(1.69)  LDD1185  [6]
 LDCM0307  AC45 PaTu 8988t C133(1.34)  LDD1186  [6]
 LDCM0308  AC46 HCT 116 C133(1.62)  LDD0625  [6]
 LDCM0309  AC47 HCT 116 C133(1.17)  LDD0626  [6]
 LDCM0310  AC48 HCT 116 C133(1.84)  LDD0627  [6]
 LDCM0311  AC49 HCT 116 C133(1.46)  LDD0628  [6]
 LDCM0312  AC5 HCT 116 C133(0.53)  LDD0629  [6]
 LDCM0313  AC50 HCT 116 C133(1.84)  LDD0630  [6]
 LDCM0314  AC51 HCT 116 C133(1.45)  LDD0631  [6]
 LDCM0315  AC52 HCT 116 C133(1.39)  LDD0632  [6]
 LDCM0316  AC53 HCT 116 C133(1.28)  LDD0633  [6]
 LDCM0317  AC54 HCT 116 C133(1.54)  LDD0634  [6]
 LDCM0318  AC55 HCT 116 C133(1.29)  LDD0635  [6]
 LDCM0319  AC56 HCT 116 C133(1.53)  LDD0636  [6]
 LDCM0320  AC57 HCT 116 C133(1.23)  LDD0637  [6]
 LDCM0321  AC58 HCT 116 C133(2.18)  LDD0638  [6]
 LDCM0322  AC59 HCT 116 C133(1.06)  LDD0639  [6]
 LDCM0323  AC6 HEK-293T C133(1.01)  LDD1562  [18]
 LDCM0324  AC60 HCT 116 C133(1.23)  LDD0641  [6]
 LDCM0325  AC61 HCT 116 C133(1.12)  LDD0642  [6]
 LDCM0326  AC62 HCT 116 C133(1.15)  LDD0643  [6]
 LDCM0327  AC63 HCT 116 C133(1.29)  LDD0644  [6]
 LDCM0328  AC64 HCT 116 C133(1.26)  LDD0645  [6]
 LDCM0329  AC65 HCT 116 C133(1.17)  LDD0646  [6]
 LDCM0330  AC66 HCT 116 C133(2.28)  LDD0647  [6]
 LDCM0331  AC67 HCT 116 C133(1.12)  LDD0648  [6]
 LDCM0332  AC68 HCT 116 C133(1.09)  LDD0649  [6]
 LDCM0333  AC69 HCT 116 C133(1.08)  LDD0650  [6]
 LDCM0334  AC7 HEK-293T C133(1.13)  LDD1568  [18]
 LDCM0335  AC70 HCT 116 C133(1.36)  LDD0652  [6]
 LDCM0336  AC71 HCT 116 C133(1.16)  LDD0653  [6]
 LDCM0337  AC72 HCT 116 C133(1.30)  LDD0654  [6]
 LDCM0338  AC73 HCT 116 C133(1.25)  LDD0655  [6]
 LDCM0339  AC74 HCT 116 C133(1.23)  LDD0656  [6]
 LDCM0340  AC75 HCT 116 C133(1.35)  LDD0657  [6]
 LDCM0341  AC76 HCT 116 C133(1.11)  LDD0658  [6]
 LDCM0342  AC77 HCT 116 C133(1.14)  LDD0659  [6]
 LDCM0343  AC78 HCT 116 C133(1.08)  LDD0660  [6]
 LDCM0344  AC79 HCT 116 C133(1.12)  LDD0661  [6]
 LDCM0345  AC8 HEK-293T C133(1.19)  LDD1569  [18]
 LDCM0346  AC80 HCT 116 C133(0.92)  LDD0663  [6]
 LDCM0347  AC81 HCT 116 C133(1.29)  LDD0664  [6]
 LDCM0348  AC82 HCT 116 C133(1.10)  LDD0665  [6]
 LDCM0349  AC83 HCT 116 C133(0.26)  LDD0666  [6]
 LDCM0350  AC84 HCT 116 C133(0.49)  LDD0667  [6]
 LDCM0351  AC85 HCT 116 C133(0.39)  LDD0668  [6]
 LDCM0352  AC86 HCT 116 C133(0.48)  LDD0669  [6]
 LDCM0353  AC87 HCT 116 C133(0.42)  LDD0670  [6]
 LDCM0354  AC88 HCT 116 C133(0.37)  LDD0671  [6]
 LDCM0355  AC89 HCT 116 C133(0.28)  LDD0672  [6]
 LDCM0357  AC90 HCT 116 C133(0.33)  LDD0674  [6]
 LDCM0358  AC91 HCT 116 C133(0.34)  LDD0675  [6]
 LDCM0359  AC92 HCT 116 C133(0.34)  LDD0676  [6]
 LDCM0360  AC93 HCT 116 C133(0.35)  LDD0677  [6]
 LDCM0361  AC94 HCT 116 C133(0.27)  LDD0678  [6]
 LDCM0362  AC95 HCT 116 C133(0.47)  LDD0679  [6]
 LDCM0363  AC96 HCT 116 C133(0.22)  LDD0680  [6]
 LDCM0364  AC97 HCT 116 C133(0.45)  LDD0681  [6]
 LDCM0365  AC98 HCT 116 C133(1.53)  LDD0682  [6]
 LDCM0366  AC99 HCT 116 C133(1.38)  LDD0683  [6]
 LDCM0248  AKOS034007472 HEK-293T C133(1.06)  LDD1511  [18]
 LDCM0356  AKOS034007680 HEK-293T C133(1.17)  LDD1570  [18]
 LDCM0275  AKOS034007705 HEK-293T C133(1.05)  LDD1514  [18]
 LDCM0156  Aniline NCI-H1299 11.03  LDD0403  [1]
 LDCM0367  CL1 HCT 116 C133(0.76)  LDD0684  [6]
 LDCM0368  CL10 HCT 116 C133(0.79)  LDD0685  [6]
 LDCM0369  CL100 HCT 116 C133(0.64)  LDD0686  [6]
 LDCM0370  CL101 HEK-293T C133(1.22)  LDD1574  [18]
 LDCM0371  CL102 HEK-293T C133(1.14)  LDD1575  [18]
 LDCM0372  CL103 HEK-293T C133(1.00)  LDD1576  [18]
 LDCM0373  CL104 HEK-293T C133(1.15)  LDD1577  [18]
 LDCM0374  CL105 PaTu 8988t C133(1.18)  LDD1253  [6]
 LDCM0375  CL106 PaTu 8988t C133(1.48)  LDD1254  [6]
 LDCM0376  CL107 PaTu 8988t C133(1.08)  LDD1255  [6]
 LDCM0377  CL108 PaTu 8988t C133(1.23)  LDD1256  [6]
 LDCM0378  CL109 PaTu 8988t C133(1.24)  LDD1257  [6]
 LDCM0379  CL11 HCT 116 C133(1.03)  LDD0696  [6]
 LDCM0380  CL110 PaTu 8988t C133(0.87)  LDD1259  [6]
 LDCM0381  CL111 PaTu 8988t C133(1.07)  LDD1260  [6]
 LDCM0382  CL112 HEK-293T C133(1.12)  LDD1586  [18]
 LDCM0383  CL113 HEK-293T C133(1.16)  LDD1587  [18]
 LDCM0384  CL114 HEK-293T C133(0.73)  LDD1588  [18]
 LDCM0385  CL115 HEK-293T C133(1.04)  LDD1589  [18]
 LDCM0386  CL116 HEK-293T C133(0.94)  LDD1590  [18]
 LDCM0387  CL117 PaTu 8988t C133(0.89)  LDD1266  [6]
 LDCM0388  CL118 PaTu 8988t C133(0.92)  LDD1267  [6]
 LDCM0389  CL119 PaTu 8988t C133(1.05)  LDD1268  [6]
 LDCM0390  CL12 HCT 116 C133(0.94)  LDD0707  [6]
 LDCM0391  CL120 PaTu 8988t C133(1.35)  LDD1270  [6]
 LDCM0392  CL121 HCT 116 C133(1.26)  LDD0709  [6]
 LDCM0393  CL122 HCT 116 C133(1.26)  LDD0710  [6]
 LDCM0394  CL123 HCT 116 C133(1.30)  LDD0711  [6]
 LDCM0395  CL124 HCT 116 C133(1.50)  LDD0712  [6]
 LDCM0396  CL125 HCT 116 C133(1.05)  LDD0713  [6]
 LDCM0397  CL126 HCT 116 C133(1.57)  LDD0714  [6]
 LDCM0398  CL127 HCT 116 C133(1.49)  LDD0715  [6]
 LDCM0399  CL128 HCT 116 C133(0.96)  LDD0716  [6]
 LDCM0400  CL13 HCT 116 C133(1.15)  LDD0717  [6]
 LDCM0401  CL14 HCT 116 C133(1.01)  LDD0718  [6]
 LDCM0402  CL15 HCT 116 C133(1.15)  LDD0719  [6]
 LDCM0403  CL16 HCT 116 C133(1.06)  LDD0720  [6]
 LDCM0404  CL17 HCT 116 C133(1.15)  LDD0721  [6]
 LDCM0405  CL18 HCT 116 C133(0.89)  LDD0722  [6]
 LDCM0406  CL19 HCT 116 C133(0.86)  LDD0723  [6]
 LDCM0407  CL2 HCT 116 C133(0.77)  LDD0724  [6]
 LDCM0408  CL20 HCT 116 C133(1.12)  LDD0725  [6]
 LDCM0409  CL21 HCT 116 C133(1.18)  LDD0726  [6]
 LDCM0410  CL22 HCT 116 C133(1.44)  LDD0727  [6]
 LDCM0411  CL23 HCT 116 C133(1.69)  LDD0728  [6]
 LDCM0412  CL24 HCT 116 C133(1.36)  LDD0729  [6]
 LDCM0413  CL25 HCT 116 C133(1.41)  LDD0730  [6]
 LDCM0414  CL26 HCT 116 C133(1.27)  LDD0731  [6]
 LDCM0415  CL27 HCT 116 C133(1.01)  LDD0732  [6]
 LDCM0416  CL28 HCT 116 C133(1.21)  LDD0733  [6]
 LDCM0417  CL29 HCT 116 C133(1.22)  LDD0734  [6]
 LDCM0418  CL3 HCT 116 C133(0.92)  LDD0735  [6]
 LDCM0419  CL30 HCT 116 C133(1.19)  LDD0736  [6]
 LDCM0420  CL31 HEK-293T C133(0.92)  LDD1624  [18]
 LDCM0421  CL32 HEK-293T C133(0.89)  LDD1625  [18]
 LDCM0422  CL33 HEK-293T C133(2.38)  LDD1626  [18]
 LDCM0423  CL34 HEK-293T C133(0.92)  LDD1627  [18]
 LDCM0424  CL35 HEK-293T C133(1.01)  LDD1628  [18]
 LDCM0425  CL36 HEK-293T C133(1.08)  LDD1629  [18]
 LDCM0426  CL37 HEK-293T C133(1.16)  LDD1630  [18]
 LDCM0428  CL39 HEK-293T C133(1.03)  LDD1632  [18]
 LDCM0429  CL4 HCT 116 C133(0.81)  LDD0746  [6]
 LDCM0430  CL40 HEK-293T C133(0.89)  LDD1634  [18]
 LDCM0431  CL41 HEK-293T C133(1.26)  LDD1635  [18]
 LDCM0432  CL42 HEK-293T C133(0.98)  LDD1636  [18]
 LDCM0433  CL43 HEK-293T C133(0.91)  LDD1637  [18]
 LDCM0434  CL44 HEK-293T C133(0.94)  LDD1638  [18]
 LDCM0435  CL45 HEK-293T C133(1.07)  LDD1639  [18]
 LDCM0436  CL46 HCT 116 C133(1.01)  LDD0753  [6]
 LDCM0437  CL47 HCT 116 C133(1.26)  LDD0754  [6]
 LDCM0438  CL48 HCT 116 C133(0.98)  LDD0755  [6]
 LDCM0439  CL49 HCT 116 C133(0.97)  LDD0756  [6]
 LDCM0440  CL5 HCT 116 C133(0.85)  LDD0757  [6]
 LDCM0441  CL50 HCT 116 C133(1.05)  LDD0758  [6]
 LDCM0442  CL51 HCT 116 C133(1.23)  LDD0759  [6]
 LDCM0443  CL52 HCT 116 C133(1.12)  LDD0760  [6]
 LDCM0444  CL53 HCT 116 C133(1.18)  LDD0761  [6]
 LDCM0445  CL54 HCT 116 C133(1.02)  LDD0762  [6]
 LDCM0446  CL55 HCT 116 C133(0.92)  LDD0763  [6]
 LDCM0447  CL56 HCT 116 C133(1.10)  LDD0764  [6]
 LDCM0448  CL57 HCT 116 C133(1.06)  LDD0765  [6]
 LDCM0449  CL58 HCT 116 C133(1.15)  LDD0766  [6]
 LDCM0450  CL59 HCT 116 C133(1.09)  LDD0767  [6]
 LDCM0451  CL6 HCT 116 C133(1.10)  LDD0768  [6]
 LDCM0452  CL60 HCT 116 C133(0.83)  LDD0769  [6]
 LDCM0453  CL61 HCT 116 C133(0.91)  LDD0770  [6]
 LDCM0454  CL62 HCT 116 C133(0.81)  LDD0771  [6]
 LDCM0455  CL63 HCT 116 C133(1.08)  LDD0772  [6]
 LDCM0456  CL64 HCT 116 C133(1.05)  LDD0773  [6]
 LDCM0457  CL65 HCT 116 C133(1.17)  LDD0774  [6]
 LDCM0458  CL66 HCT 116 C133(0.97)  LDD0775  [6]
 LDCM0459  CL67 HCT 116 C133(1.27)  LDD0776  [6]
 LDCM0460  CL68 HCT 116 C133(1.68)  LDD0777  [6]
 LDCM0461  CL69 HCT 116 C133(1.01)  LDD0778  [6]
 LDCM0462  CL7 HCT 116 C133(0.77)  LDD0779  [6]
 LDCM0463  CL70 HCT 116 C133(0.97)  LDD0780  [6]
 LDCM0464  CL71 HCT 116 C133(1.20)  LDD0781  [6]
 LDCM0465  CL72 HCT 116 C133(1.29)  LDD0782  [6]
 LDCM0466  CL73 HCT 116 C133(1.40)  LDD0783  [6]
 LDCM0467  CL74 HCT 116 C133(1.55)  LDD0784  [6]
 LDCM0469  CL76 HEK-293T C133(0.91)  LDD1672  [18]
 LDCM0470  CL77 HEK-293T C133(1.21)  LDD1673  [18]
 LDCM0471  CL78 HEK-293T C133(0.87)  LDD1674  [18]
 LDCM0472  CL79 HEK-293T C133(0.87)  LDD1675  [18]
 LDCM0473  CL8 HCT 116 C133(0.77)  LDD0790  [6]
 LDCM0474  CL80 HEK-293T C133(0.83)  LDD1677  [18]
 LDCM0475  CL81 HEK-293T C133(0.90)  LDD1678  [18]
 LDCM0476  CL82 HEK-293T C133(0.90)  LDD1679  [18]
 LDCM0477  CL83 HEK-293T C133(0.92)  LDD1680  [18]
 LDCM0478  CL84 HEK-293T C133(1.02)  LDD1681  [18]
 LDCM0479  CL85 HEK-293T C133(1.01)  LDD1682  [18]
 LDCM0480  CL86 HEK-293T C133(1.05)  LDD1683  [18]
 LDCM0481  CL87 HEK-293T C133(1.06)  LDD1684  [18]
 LDCM0482  CL88 HEK-293T C133(1.02)  LDD1685  [18]
 LDCM0483  CL89 HEK-293T C133(1.04)  LDD1686  [18]
 LDCM0484  CL9 HCT 116 C133(1.02)  LDD0801  [6]
 LDCM0485  CL90 HEK-293T C133(2.06)  LDD1688  [18]
 LDCM0486  CL91 HCT 116 C133(1.08)  LDD0803  [6]
 LDCM0487  CL92 HCT 116 C133(1.12)  LDD0804  [6]
 LDCM0488  CL93 HCT 116 C133(1.02)  LDD0805  [6]
 LDCM0489  CL94 HCT 116 C133(1.06)  LDD0806  [6]
 LDCM0490  CL95 HCT 116 C133(0.99)  LDD0807  [6]
 LDCM0491  CL96 HCT 116 C133(0.61)  LDD0808  [6]
 LDCM0492  CL97 HCT 116 C133(0.68)  LDD0809  [6]
 LDCM0493  CL98 HCT 116 C133(0.54)  LDD0810  [6]
 LDCM0494  CL99 HCT 116 C133(0.55)  LDD0811  [6]
 LDCM0495  E2913 HEK-293T C133(0.97)  LDD1698  [18]
 LDCM0572  Fragment10 MDA-MB-231 C133(1.59)  LDD1465  [19]
 LDCM0573  Fragment11 MDA-MB-231 C133(3.51)  LDD1391  [19]
 LDCM0574  Fragment12 MDA-MB-231 C133(1.16)  LDD1468  [19]
 LDCM0575  Fragment13 MDA-MB-231 C133(1.11)  LDD1469  [19]
 LDCM0576  Fragment14 MDA-MB-231 C133(1.73)  LDD1397  [19]
 LDCM0580  Fragment21 MDA-MB-231 C133(1.03)  LDD1404  [19]
 LDCM0578  Fragment27 MDA-MB-231 C133(1.43)  LDD1401  [19]
 LDCM0586  Fragment28 MDA-MB-231 C133(1.23)  LDD1415  [19]
 LDCM0587  Fragment29 MDA-MB-231 C133(1.07)  LDD1417  [19]
 LDCM0590  Fragment32 MDA-MB-231 C133(2.24)  LDD1423  [19]
 LDCM0468  Fragment33 HCT 116 C133(0.91)  LDD0785  [6]
 LDCM0594  Fragment36 MDA-MB-231 C133(1.33)  LDD1431  [19]
 LDCM0596  Fragment38 MDA-MB-231 C133(1.18)  LDD1433  [19]
 LDCM0566  Fragment4 MDA-MB-231 C133(2.18)  LDD1378  [19]
 LDCM0601  Fragment43 MDA-MB-231 C133(2.35)  LDD1441  [19]
 LDCM0603  Fragment45 MDA-MB-231 C133(4.18)  LDD1482  [19]
 LDCM0604  Fragment46 MDA-MB-231 C133(0.97)  LDD1445  [19]
 LDCM0427  Fragment51 HEK-293T C133(1.07)  LDD1631  [18]
 LDCM0611  Fragment53 MDA-MB-231 C133(0.93)  LDD1454  [19]
 LDCM0614  Fragment56 MDA-MB-231 C133(0.90)  LDD1484  [19]
 LDCM0568  Fragment6 MDA-MB-231 C133(1.15)  LDD1382  [19]
 LDCM0569  Fragment7 MDA-MB-231 C133(4.81)  LDD1383  [19]
 LDCM0570  Fragment8 MDA-MB-231 C133(1.96)  LDD1462  [19]
 LDCM0571  Fragment9 MDA-MB-231 C133(20.00)  LDD1387  [19]
 LDCM0022  KB02 MDA-MB-231 C133(3.77)  LDD1374  [19]
 LDCM0023  KB03 MDA-MB-231 C133(3.09)  LDD1376  [19]
 LDCM0024  KB05 MKN45 C52(1.85)  LDD3332  [20]
 LDCM0131  RA190 MM1.R C133(1.25)  LDD0304  [21]
 LDCM0154  YY4 T cell 3.17  LDD0400  [5]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 A Chemical Proteomic Probe for the Mitochondrial Pyruvate Carrier Complex. Angew Chem Int Ed Engl. 2020 Mar 2;59(10):3896-3899. doi: 10.1002/anie.201914391. Epub 2020 Feb 11.
6 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
12 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
13 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
14 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
15 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
16 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
17 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
18 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
19 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
20 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
21 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.