Details of the Target

General Information of Target

Target ID LDTP04952
Target Name Heterogeneous nuclear ribonucleoprotein K (HNRNPK)
Gene Name HNRNPK
Gene ID 3190
Synonyms
HNRPK; Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
METEQPEETFPNTETNGEFGKRPAEDMEEEQAFKRSRNTDEMVELRILLQSKNAGAVIGK
GGKNIKALRTDYNASVSVPDSSGPERILSISADIETIGEILKKIIPTLEEGLQLPSPTAT
SQLPLESDAVECLNYQHYKGSDFDCELRLLIHQSLAGGIIGVKGAKIKELRENTQTTIKL
FQECCPHSTDRVVLIGGKPDRVVECIKIILDLISESPIKGRAQPYDPNFYDETYDYGGFT
MMFDDRRGRPVGFPMRGRGGFDRMPPGRGGRPMPPSRRDYDDMSPRRGPPPPPPGRGGRG
GSRARNLPLPPPPPPRGGDLMAYDRRGRPGDRYDGMVGFSADETWDSAIDTWSPSEWQMA
YEPQGGSGYDYSYAGGRGSYGDLGGPIITTQVTIPKDLAGSIIGKGGQRIKQIRHESGAS
IKIDEPLEGSEDRIITITGTQDQIQNAQYLLQNSVKQYSGKFF
Target Bioclass
Other
Subcellular location
Cytoplasm
Function
One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single-stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction. As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cell cycle arrest. As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPL and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation.
Uniprot ID
P61978
Ensemble ID
ENST00000351839.7
HGNC ID
HGNC:5044

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 67 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		13.12  LDD0402  [1]
P1
 Probe Info  		8.65  LDD0452  [2]
P2
 Probe Info  		3.68  LDD0449  [2]
P3
 Probe Info  		1.86  LDD0450  [2]
P8
 Probe Info  		3.04  LDD0451  [2]
A-EBA
 Probe Info  		4.47  LDD0215  [3]
ILS-1
 Probe Info  		2.29; 4.29  LDD0415  [4]
11RK72
 Probe Info  		2.96  LDD0327  [5]
11RK73
 Probe Info  		2.86  LDD0328  [5]
CY-1
 Probe Info  		39.90  LDD0243  [6]
CY4
 Probe Info  		14.44  LDD0244  [6]
TH211
 Probe Info  		Y225(20.00); Y230(20.00); Y323(19.37); Y380(18.11)  LDD0257  [7]
TH214
 Probe Info  		Y72(20.00)  LDD0258  [7]
TH216
 Probe Info  		Y323(20.00); Y380(20.00); Y449(20.00); Y138(10.24)  LDD0259  [7]
YN-4
 Probe Info  		100.00  LDD0445  [8]
AZ-9
 Probe Info  		E428(1.02); E30(1.26)  LDD2208  [9]
ONAyne
 Probe Info  		K34(0.00); K405(0.00); K456(0.00); K60(0.00)  LDD0273  [10]
OPA-S-S-alkyne
 Probe Info  		K219(0.79); K198(1.88); K179(3.68); K34(3.82)  LDD3494  [11]
Probe 1
 Probe Info  		Y72(851.78); Y280(50.44); Y323(177.20); Y380(564.18)  LDD3495  [12]
JZ128-DTB
 Probe Info  		C145(0.00); C132(0.00)  LDD0462  [13]
THZ1-DTB
 Probe Info  		C145(1.09); C132(1.04)  LDD0460  [13]
AHL-Pu-1
 Probe Info  		C132(3.77)  LDD0169  [14]
EA-probe
 Probe Info  		C132(1.08); C132(0.97)  LDD2210  [15]
DBIA
 Probe Info  		C132(7.58); C145(4.48)  LDD0209  [16]
HHS-482
 Probe Info  		Y135(0.81); Y138(1.08); Y280(0.91); Y323(0.99)  LDD0285  [17]
HHS-475
 Probe Info  		Y135(0.79); Y230(0.88); Y280(0.88); Y138(0.90)  LDD0264  [18]
HHS-465
 Probe Info  		Y135(5.71); Y234(10.00); Y280(10.00); Y323(10.00)  LDD2237  [19]
5E-2FA
 Probe Info  		H187(0.00); H152(0.00); H415(0.00)  LDD2235  [20]
AMP probe
 Probe Info  		K405(0.00); K422(0.00); K219(0.00); K60(0.00)  LDD0200  [21]
ATP probe
 Probe Info  		K405(0.00); K422(0.00); K219(0.00); K60(0.00)  LDD0199  [21]
N1
 Probe Info  		C185(0.00); D190(0.00); E183(0.00); H187(0.00)  LDD0245  [6]
4-Iodoacetamidophenylacetylene
 Probe Info  		C145(0.00); C132(0.00); C184(0.00); C185(0.00)  LDD0038  [22]
IA-alkyne
 Probe Info  		C132(0.00); C145(0.00)  LDD0032  [23]
IPIAA_H
 Probe Info  		C132(0.00); C145(0.00)  LDD0030  [24]
IPIAA_L
 Probe Info  		C145(0.00); C184(0.00); C132(0.00)  LDD0031  [24]
Lodoacetamide azide
 Probe Info  		C145(0.00); C132(0.00); C184(0.00); C185(0.00)  LDD0037  [22]
ATP probe
 Probe Info  		K422(0.00); K219(0.00); K207(0.00); K198(0.00)  LDD0035  [25]
BTD
 Probe Info  		N.A.  LDD0004  [26]
JW-RF-010
 Probe Info  		C132(0.00); C145(0.00); C185(0.00); C184(0.00)  LDD0026  [27]
NAIA_4
 Probe Info  		N.A.  LDD2226  [28]
TFBX
 Probe Info  		C185(0.00); C205(0.00); C145(0.00); C184(0.00)  LDD0027  [27]
WYneN
 Probe Info  		C132(0.00); C185(0.00); C145(0.00)  LDD0021  [26]
WYneO
 Probe Info  		N.A.  LDD0022  [26]
aHNE
 Probe Info  		N.A.  LDD0001  [26]
1d-yne
 Probe Info  		K422(0.00); K103(0.00)  LDD0356  [29]
Compound 10
 Probe Info  		C132(0.00); C145(0.00); C184(0.00); C185(0.00)  LDD2216  [30]
Compound 11
 Probe Info  		C132(0.00); C185(0.00)  LDD2213  [30]
ENE
 Probe Info  		C145(0.00); C205(0.00)  LDD0006  [26]
IPM
 Probe Info  		C132(0.00); C185(0.00)  LDD0005  [26]
NHS
 Probe Info  		K422(0.00); K219(0.00); K34(0.00); K163(0.00)  LDD0010  [26]
OSF
 Probe Info  		Y449(0.00); Y280(0.00); H415(0.00)  LDD0029  [31]
PF-06672131
 Probe Info  		N.A.  LDD0152  [32]
PPMS
 Probe Info  		N.A.  LDD0008  [26]
SF
 Probe Info  		Y135(0.00); Y280(0.00); K139(0.00); K52(0.00)  LDD0028  [31]
STPyne
 Probe Info  		K405(0.00); K422(0.00); K52(0.00); K198(0.00)  LDD0009  [26]
VSF
 Probe Info  		C132(0.00); C145(0.00)  LDD0007  [26]
YN-1
 Probe Info  		N.A.  LDD0446  [8]
Phosphinate-6
 Probe Info  		C185(0.00); C132(0.00); C145(0.00); C184(0.00)  LDD0018  [33]
1c-yne
 Probe Info  		K422(0.00); K103(0.00); K456(0.00); K396(0.00)  LDD0228  [29]
Acrolein
 Probe Info  		H152(0.00); C132(0.00); C184(0.00); H415(0.00)  LDD0217  [34]
Cinnamaldehyde
 Probe Info  		C184(0.00); C145(0.00); C185(0.00)  LDD0220  [34]
Crotonaldehyde
 Probe Info  		C184(0.00); H415(0.00); C145(0.00); C205(0.00)  LDD0219  [34]
Methacrolein
 Probe Info  		C184(0.00); H152(0.00); C145(0.00); C205(0.00)  LDD0218  [34]
W1
 Probe Info  		C145(0.00); C184(0.00); C185(0.00); C132(0.00)  LDD0236  [35]
AOyne
 Probe Info  		6.00  LDD0443  [36]
MPP-AC
 Probe Info  		N.A.  LDD0428  [37]
NAIA_5
 Probe Info  		C184(0.00); C145(0.00); C185(0.00); C205(0.00)  LDD2223  [28]
PAL-AfBPP Probe
Click To Hide/Show 22 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C191
 Probe Info  		9.71  LDD1868  [38]
C206
 Probe Info  		15.67  LDD1881  [38]
C232
 Probe Info  		37.79  LDD1905  [38]
C313
 Probe Info  		12.30  LDD1980  [38]
C322
 Probe Info  		5.62  LDD1988  [38]
C338
 Probe Info  		19.84  LDD2001  [38]
C348
 Probe Info  		10.13  LDD2009  [38]
C353
 Probe Info  		7.46  LDD2014  [38]
FFF probe11
 Probe Info  		6.30  LDD0471  [39]
FFF probe12
 Probe Info  		5.52  LDD0473  [39]
FFF probe13
 Probe Info  		13.81  LDD0475  [39]
FFF probe14
 Probe Info  		9.67  LDD0477  [39]
FFF probe2
 Probe Info  		11.04  LDD0463  [39]
FFF probe3
 Probe Info  		9.22  LDD0464  [39]
FFF probe4
 Probe Info  		6.53  LDD0466  [39]
JN0003
 Probe Info  		11.37  LDD0469  [39]
STS-2
 Probe Info  		N.A.  LDD0138  [40]
VE-P
 Probe Info  		N.A.  LDD0396  [41]
BD-F
 Probe Info  		T438(0.00); Q445(0.00); I444(0.00)  LDD0024  [42]
LD-F
 Probe Info  		A447(0.00); D382(0.00); P106(0.00); L114(0.00)  LDD0015  [42]
OEA-DA
 Probe Info  		3.25  LDD0046  [43]
STS-1
 Probe Info  		N.A.  LDD0068  [44]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C185(0.63); C184(0.71); C205(0.44); C145(0.50)  LDD2142  [45]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C185(0.92); C184(0.83); C205(0.70); C145(0.78)  LDD2112  [45]
 LDCM0502  1-(Cyanoacetyl)piperidine MDA-MB-231 C185(1.10); C184(0.96); C205(0.68)  LDD2095  [45]
 LDCM0537  2-Cyano-N,N-dimethylacetamide MDA-MB-231 C184(1.05); C205(0.76)  LDD2130  [45]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C185(0.84); C184(0.89); C205(1.15); C145(1.30)  LDD2117  [45]
 LDCM0558  2-Cyano-N-phenylacetamide MDA-MB-231 C184(1.13); C205(1.60); C145(1.48)  LDD2152  [45]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C185(1.03); C184(1.07); C145(0.97)  LDD2103  [45]
 LDCM0539  3-(4-Isopropylpiperazin-1-yl)-3-oxopropanenitrile MDA-MB-231 C185(0.91); C184(0.80)  LDD2132  [45]
 LDCM0538  4-(Cyanoacetyl)morpholine MDA-MB-231 C185(1.00); C184(0.81); C205(0.62)  LDD2131  [45]
 LDCM0026  4SU-RNA+native RNA HEK-293T C132(3.77)  LDD0169  [14]
 LDCM0214  AC1 HEK-293T C145(0.88); C132(1.07); C185(0.98)  LDD1507  [46]
 LDCM0215  AC10 HEK-293T C145(1.00); C132(1.17); C185(1.00)  LDD1508  [46]
 LDCM0226  AC11 HEK-293T C145(0.98); C132(0.97); C185(0.88)  LDD1509  [46]
 LDCM0237  AC12 HEK-293T C145(1.01); C132(1.00); C185(0.97)  LDD1510  [46]
 LDCM0259  AC14 HEK-293T C145(1.07); C132(1.02); C185(1.01)  LDD1512  [46]
 LDCM0270  AC15 HEK-293T C145(1.03); C132(1.05); C185(0.88)  LDD1513  [46]
 LDCM0276  AC17 HEK-293T C145(0.83); C132(1.08); C185(0.98)  LDD1515  [46]
 LDCM0277  AC18 HEK-293T C145(0.95); C132(1.03); C185(0.94)  LDD1516  [46]
 LDCM0278  AC19 HEK-293T C145(0.74); C132(0.93); C185(0.83)  LDD1517  [46]
 LDCM0279  AC2 HEK-293T C145(0.98); C132(1.12); C185(1.03)  LDD1518  [46]
 LDCM0280  AC20 HEK-293T C145(1.03); C132(1.09); C185(1.04)  LDD1519  [46]
 LDCM0281  AC21 HEK-293T C145(1.13); C132(1.09); C185(1.08)  LDD1520  [46]
 LDCM0282  AC22 HEK-293T C145(1.04); C132(1.01); C185(1.07)  LDD1521  [46]
 LDCM0283  AC23 HEK-293T C145(1.06); C132(1.00); C185(0.89)  LDD1522  [46]
 LDCM0284  AC24 HEK-293T C145(1.06); C132(0.99); C185(0.99)  LDD1523  [46]
 LDCM0285  AC25 HEK-293T C145(0.86); C132(1.09); C185(0.96)  LDD1524  [46]
 LDCM0286  AC26 HEK-293T C145(0.97); C132(1.12); C185(0.94)  LDD1525  [46]
 LDCM0287  AC27 HEK-293T C145(0.98); C132(1.02); C185(0.94)  LDD1526  [46]
 LDCM0288  AC28 HEK-293T C145(1.10); C132(1.07); C185(1.05)  LDD1527  [46]
 LDCM0289  AC29 HEK-293T C145(1.10); C132(1.09); C185(1.14)  LDD1528  [46]
 LDCM0290  AC3 HEK-293T C145(0.97); C132(1.04); C185(0.96)  LDD1529  [46]
 LDCM0291  AC30 HEK-293T C145(1.09); C132(0.97); C185(1.02)  LDD1530  [46]
 LDCM0292  AC31 HEK-293T C145(1.07); C132(1.06); C185(1.01)  LDD1531  [46]
 LDCM0293  AC32 HEK-293T C145(1.02); C132(1.04); C185(1.05)  LDD1532  [46]
 LDCM0294  AC33 HEK-293T C145(0.91); C132(1.11); C185(1.05)  LDD1533  [46]
 LDCM0295  AC34 HEK-293T C145(0.99); C132(1.04); C185(0.97)  LDD1534  [46]
 LDCM0296  AC35 HEK-293T C145(1.01); C132(1.13); C185(0.93)  LDD1535  [46]
 LDCM0297  AC36 HEK-293T C145(1.05); C132(1.10); C185(1.04)  LDD1536  [46]
 LDCM0298  AC37 HEK-293T C145(1.14); C132(1.02); C185(1.09)  LDD1537  [46]
 LDCM0299  AC38 HEK-293T C145(1.10); C132(1.04); C185(0.95)  LDD1538  [46]
 LDCM0300  AC39 HEK-293T C145(0.97); C132(1.02); C185(0.92)  LDD1539  [46]
 LDCM0301  AC4 HEK-293T C145(1.08); C132(1.06); C185(0.99)  LDD1540  [46]
 LDCM0302  AC40 HEK-293T C145(0.99); C132(1.00); C185(1.04)  LDD1541  [46]
 LDCM0303  AC41 HEK-293T C145(0.81); C132(1.11); C185(0.90)  LDD1542  [46]
 LDCM0304  AC42 HEK-293T C145(1.00); C132(1.12); C185(1.06)  LDD1543  [46]
 LDCM0305  AC43 HEK-293T C145(0.96); C132(1.03); C185(0.98)  LDD1544  [46]
 LDCM0306  AC44 HEK-293T C145(1.03); C132(1.06); C185(0.97)  LDD1545  [46]
 LDCM0307  AC45 HEK-293T C145(1.02); C132(1.06); C185(1.04)  LDD1546  [46]
 LDCM0308  AC46 HEK-293T C145(1.05); C132(1.16); C185(1.02)  LDD1547  [46]
 LDCM0309  AC47 HEK-293T C145(0.99); C132(1.04); C185(0.86)  LDD1548  [46]
 LDCM0310  AC48 HEK-293T C145(0.99); C132(1.03); C185(1.04)  LDD1549  [46]
 LDCM0311  AC49 HEK-293T C145(0.88); C132(1.07); C185(0.90)  LDD1550  [46]
 LDCM0312  AC5 HEK-293T C145(1.14); C132(1.06); C185(0.92)  LDD1551  [46]
 LDCM0313  AC50 HEK-293T C145(1.03); C132(1.06); C185(0.92)  LDD1552  [46]
 LDCM0314  AC51 HEK-293T C145(1.01); C132(1.00); C185(0.97)  LDD1553  [46]
 LDCM0315  AC52 HEK-293T C145(1.03); C132(1.01); C185(0.93)  LDD1554  [46]
 LDCM0316  AC53 HEK-293T C145(1.06); C132(1.03); C185(0.96)  LDD1555  [46]
 LDCM0317  AC54 HEK-293T C145(1.07); C132(1.04); C185(0.97)  LDD1556  [46]
 LDCM0318  AC55 HEK-293T C145(0.98); C132(0.99); C185(0.78)  LDD1557  [46]
 LDCM0319  AC56 HEK-293T C145(1.01); C132(1.01); C185(0.99)  LDD1558  [46]
 LDCM0320  AC57 HEK-293T C145(0.83); C132(1.10); C185(0.91)  LDD1559  [46]
 LDCM0321  AC58 HEK-293T C145(1.10); C132(1.05); C185(1.02)  LDD1560  [46]
 LDCM0322  AC59 HEK-293T C145(1.06); C132(1.05); C185(0.95)  LDD1561  [46]
 LDCM0323  AC6 HEK-293T C145(1.01); C132(1.04); C185(0.92)  LDD1562  [46]
 LDCM0324  AC60 HEK-293T C145(0.98); C132(1.10); C185(1.10)  LDD1563  [46]
 LDCM0325  AC61 HEK-293T C145(1.09); C132(1.12); C185(0.89)  LDD1564  [46]
 LDCM0326  AC62 HEK-293T C145(1.04); C132(1.05); C185(0.90)  LDD1565  [46]
 LDCM0327  AC63 HEK-293T C145(1.01); C132(1.07); C185(0.95)  LDD1566  [46]
 LDCM0328  AC64 HEK-293T C145(1.07); C132(1.09); C185(1.02)  LDD1567  [46]
 LDCM0334  AC7 HEK-293T C145(1.06); C132(1.00); C185(0.89)  LDD1568  [46]
 LDCM0345  AC8 HEK-293T C145(1.08); C132(1.06); C185(1.04)  LDD1569  [46]
 LDCM0545  Acetamide MDA-MB-231 C185(0.98); C184(0.81); C205(0.65); C145(0.67)  LDD2138  [45]
 LDCM0520  AKOS000195272 MDA-MB-231 C184(0.80); C145(0.74)  LDD2113  [45]
 LDCM0248  AKOS034007472 HEK-293T C145(1.16); C132(1.04); C185(0.94)  LDD1511  [46]
 LDCM0356  AKOS034007680 HEK-293T C145(0.82); C132(1.10); C185(0.94)  LDD1570  [46]
 LDCM0275  AKOS034007705 HEK-293T C145(1.05); C132(0.98); C185(0.98)  LDD1514  [46]
 LDCM0156  Aniline NCI-H1299 C185(0.00); C132(0.00)  LDD0404  [1]
 LDCM0498  BS-3668 MDA-MB-231 C185(1.45); C184(1.16); C205(0.72)  LDD2091  [45]
 LDCM0630  CCW28-3 231MFP C132(1.59)  LDD2214  [47]
 LDCM0108  Chloroacetamide HeLa C132(0.00); H152(0.00); C184(0.00); C185(0.00)  LDD0222  [34]
 LDCM0632  CL-Sc Hep-G2 C145(3.92); C184(0.84); C184(0.69)  LDD2227  [28]
 LDCM0367  CL1 HEK-293T C145(0.98); C132(0.93); C185(0.88)  LDD1571  [46]
 LDCM0368  CL10 HEK-293T C145(0.94); C132(0.67); C185(0.83)  LDD1572  [46]
 LDCM0369  CL100 HEK-293T C145(0.95); C132(1.10); C185(0.88)  LDD1573  [46]
 LDCM0370  CL101 HEK-293T C145(0.96); C132(1.03); C185(0.82)  LDD1574  [46]
 LDCM0371  CL102 HEK-293T C145(0.91); C132(1.14); C185(0.97)  LDD1575  [46]
 LDCM0372  CL103 HEK-293T C145(0.98); C132(1.03); C185(0.92)  LDD1576  [46]
 LDCM0373  CL104 HEK-293T C145(1.05); C132(1.01); C185(0.84)  LDD1577  [46]
 LDCM0374  CL105 HEK-293T C145(1.02); C132(1.03); C185(0.98)  LDD1578  [46]
 LDCM0375  CL106 HEK-293T C145(1.02); C132(1.00); C185(0.99)  LDD1579  [46]
 LDCM0376  CL107 HEK-293T C145(0.98); C132(1.05); C185(0.97)  LDD1580  [46]
 LDCM0377  CL108 HEK-293T C145(1.02); C132(1.02); C185(1.01)  LDD1581  [46]
 LDCM0378  CL109 HEK-293T C145(0.91); C132(1.02); C185(0.98)  LDD1582  [46]
 LDCM0379  CL11 HEK-293T C145(0.98); C132(0.53); C185(0.82)  LDD1583  [46]
 LDCM0380  CL110 HEK-293T C145(0.87); C132(0.93); C185(0.99)  LDD1584  [46]
 LDCM0381  CL111 HEK-293T C145(0.91); C132(1.00); C185(0.91)  LDD1585  [46]
 LDCM0382  CL112 HEK-293T C145(0.94); C132(1.06); C185(0.96)  LDD1586  [46]
 LDCM0383  CL113 HEK-293T C145(1.01); C132(1.00); C185(1.02)  LDD1587  [46]
 LDCM0384  CL114 HEK-293T C145(0.87); C132(1.13); C185(1.04)  LDD1588  [46]
 LDCM0385  CL115 HEK-293T C145(0.95); C132(1.11); C185(0.97)  LDD1589  [46]
 LDCM0386  CL116 HEK-293T C145(1.00); C132(1.17); C185(0.86)  LDD1590  [46]
 LDCM0387  CL117 HEK-293T C145(0.98); C132(1.01); C185(0.95)  LDD1591  [46]
 LDCM0388  CL118 HEK-293T C145(0.98); C132(1.04); C185(0.96)  LDD1592  [46]
 LDCM0389  CL119 HEK-293T C145(1.00); C132(1.01); C185(1.02)  LDD1593  [46]
 LDCM0390  CL12 HEK-293T C145(1.03); C132(0.57); C185(1.03)  LDD1594  [46]
 LDCM0391  CL120 HEK-293T C145(1.03); C132(1.01); C185(0.99)  LDD1595  [46]
 LDCM0392  CL121 HEK-293T C145(0.94); C132(0.95); C185(0.91)  LDD1596  [46]
 LDCM0393  CL122 HEK-293T C145(0.98); C132(1.03); C185(0.97)  LDD1597  [46]
 LDCM0394  CL123 HEK-293T C145(0.91); C132(0.99); C185(0.84)  LDD1598  [46]
 LDCM0395  CL124 HEK-293T C145(0.89); C132(0.99); C185(0.81)  LDD1599  [46]
 LDCM0396  CL125 HEK-293T C145(1.11); C132(0.99); C185(0.85)  LDD1600  [46]
 LDCM0397  CL126 HEK-293T C145(1.03); C132(1.08); C185(0.97)  LDD1601  [46]
 LDCM0398  CL127 HEK-293T C145(1.05); C132(1.13); C185(0.96)  LDD1602  [46]
 LDCM0399  CL128 HEK-293T C145(1.06); C132(1.02); C185(0.91)  LDD1603  [46]
 LDCM0400  CL13 HEK-293T C145(0.85); C132(1.04); C185(0.69)  LDD1604  [46]
 LDCM0401  CL14 HEK-293T C145(0.96); C132(0.97); C185(0.93)  LDD1605  [46]
 LDCM0402  CL15 HEK-293T C145(0.77); C132(0.89); C185(0.70)  LDD1606  [46]
 LDCM0403  CL16 HEK-293T C145(1.02); C132(0.97); C185(0.83)  LDD1607  [46]
 LDCM0404  CL17 HEK-293T C145(0.67); C132(1.05); C185(0.68)  LDD1608  [46]
 LDCM0405  CL18 HEK-293T C145(0.98); C132(0.82); C185(0.79)  LDD1609  [46]
 LDCM0406  CL19 HEK-293T C145(0.90); C132(0.84); C185(0.75)  LDD1610  [46]
 LDCM0407  CL2 HEK-293T C145(0.90); C132(1.00); C185(0.86)  LDD1611  [46]
 LDCM0408  CL20 HEK-293T C145(0.97); C132(0.69); C185(0.82)  LDD1612  [46]
 LDCM0409  CL21 HEK-293T C145(1.04); C132(0.64); C185(0.74)  LDD1613  [46]
 LDCM0410  CL22 HEK-293T C145(1.10); C132(0.68); C185(0.79)  LDD1614  [46]
 LDCM0411  CL23 HEK-293T C145(1.05); C132(0.55); C185(0.82)  LDD1615  [46]
 LDCM0412  CL24 HEK-293T C145(1.06); C132(0.60); C185(0.93)  LDD1616  [46]
 LDCM0413  CL25 HEK-293T C145(0.96); C132(0.85); C185(0.83)  LDD1617  [46]
 LDCM0414  CL26 HEK-293T C145(1.04); C132(0.99); C185(0.96)  LDD1618  [46]
 LDCM0415  CL27 HEK-293T C145(1.07); C132(1.02); C185(0.88)  LDD1619  [46]
 LDCM0416  CL28 HEK-293T C145(0.99); C132(0.91); C185(0.83)  LDD1620  [46]
 LDCM0417  CL29 HEK-293T C145(1.01); C132(1.06); C185(0.97)  LDD1621  [46]
 LDCM0418  CL3 HEK-293T C145(0.88); C132(0.97); C185(0.85)  LDD1622  [46]
 LDCM0419  CL30 HEK-293T C145(1.09); C132(0.80); C185(0.90)  LDD1623  [46]
 LDCM0420  CL31 HEK-293T C145(0.97); C132(0.83); C185(0.78)  LDD1624  [46]
 LDCM0421  CL32 HEK-293T C145(1.09); C132(0.74); C185(0.95)  LDD1625  [46]
 LDCM0422  CL33 HEK-293T C145(1.09); C132(0.63); C185(0.74)  LDD1626  [46]
 LDCM0423  CL34 HEK-293T C145(1.12); C132(0.63); C185(0.87)  LDD1627  [46]
 LDCM0424  CL35 HEK-293T C145(1.19); C132(0.50); C185(0.97)  LDD1628  [46]
 LDCM0425  CL36 HEK-293T C145(1.17); C132(0.57); C185(0.96)  LDD1629  [46]
 LDCM0426  CL37 HEK-293T C145(1.03); C132(0.95); C185(0.94)  LDD1630  [46]
 LDCM0428  CL39 HEK-293T C145(1.00); C132(1.09); C185(1.00)  LDD1632  [46]
 LDCM0429  CL4 HEK-293T C145(0.89); C132(0.97); C185(0.65)  LDD1633  [46]
 LDCM0430  CL40 HEK-293T C145(1.07); C132(0.98); C185(0.92)  LDD1634  [46]
 LDCM0431  CL41 HEK-293T C145(0.84); C132(1.04); C185(1.01)  LDD1635  [46]
 LDCM0432  CL42 HEK-293T C145(1.13); C132(0.84); C185(0.78)  LDD1636  [46]
 LDCM0433  CL43 HEK-293T C145(1.30); C132(0.80); C185(0.95)  LDD1637  [46]
 LDCM0434  CL44 HEK-293T C145(1.14); C132(0.76); C185(0.93)  LDD1638  [46]
 LDCM0435  CL45 HEK-293T C145(1.13); C132(0.73); C185(0.81)  LDD1639  [46]
 LDCM0436  CL46 HEK-293T C145(1.27); C132(0.68); C185(0.92)  LDD1640  [46]
 LDCM0437  CL47 HEK-293T C145(1.23); C132(0.52); C185(0.94)  LDD1641  [46]
 LDCM0438  CL48 HEK-293T C145(1.22); C132(0.59); C185(0.91)  LDD1642  [46]
 LDCM0439  CL49 HEK-293T C145(1.00); C132(0.87); C185(0.85)  LDD1643  [46]
 LDCM0440  CL5 HEK-293T C145(0.82); C132(1.16); C185(0.70)  LDD1644  [46]
 LDCM0441  CL50 HEK-293T C145(0.92); C132(1.06); C185(0.91)  LDD1645  [46]
 LDCM0443  CL52 HEK-293T C145(0.90); C132(0.96); C185(0.89)  LDD1646  [46]
 LDCM0444  CL53 HEK-293T C145(0.79); C132(0.99); C185(0.86)  LDD1647  [46]
 LDCM0445  CL54 HEK-293T C145(0.89); C132(0.77); C185(0.77)  LDD1648  [46]
 LDCM0446  CL55 HEK-293T C145(1.11); C132(0.79); C185(0.89)  LDD1649  [46]
 LDCM0447  CL56 HEK-293T C145(1.12); C132(0.77); C185(0.97)  LDD1650  [46]
 LDCM0448  CL57 HEK-293T C145(1.12); C132(0.76); C185(0.77)  LDD1651  [46]
 LDCM0449  CL58 HEK-293T C145(1.12); C132(0.64); C185(0.83)  LDD1652  [46]
 LDCM0450  CL59 HEK-293T C145(1.09); C132(0.55); C185(0.78)  LDD1653  [46]
 LDCM0451  CL6 HEK-293T C145(0.87); C132(0.81); C185(0.77)  LDD1654  [46]
 LDCM0452  CL60 HEK-293T C145(1.16); C132(0.59); C185(1.03)  LDD1655  [46]
 LDCM0453  CL61 HEK-293T C145(1.06); C132(0.93); C185(0.92)  LDD1656  [46]
 LDCM0454  CL62 HEK-293T C145(1.00); C132(1.21); C185(0.95)  LDD1657  [46]
 LDCM0455  CL63 HEK-293T C145(1.02); C132(1.05); C185(0.99)  LDD1658  [46]
 LDCM0456  CL64 HEK-293T C145(0.94); C132(0.92); C185(0.78)  LDD1659  [46]
 LDCM0457  CL65 HEK-293T C145(0.95); C132(1.22); C185(0.92)  LDD1660  [46]
 LDCM0458  CL66 HEK-293T C145(1.00); C132(0.95); C185(0.78)  LDD1661  [46]
 LDCM0459  CL67 HEK-293T C145(1.06); C132(0.88); C185(0.99)  LDD1662  [46]
 LDCM0460  CL68 HEK-293T C145(1.12); C132(0.79); C185(0.90)  LDD1663  [46]
 LDCM0461  CL69 HEK-293T C145(1.16); C132(0.76); C185(0.77)  LDD1664  [46]
 LDCM0462  CL7 HEK-293T C145(0.91); C132(0.83); C185(0.74)  LDD1665  [46]
 LDCM0463  CL70 HEK-293T C145(1.17); C132(0.72); C185(0.88)  LDD1666  [46]
 LDCM0464  CL71 HEK-293T C145(1.13); C132(0.59); C185(0.85)  LDD1667  [46]
 LDCM0465  CL72 HEK-293T C145(1.11); C132(0.64); C185(0.96)  LDD1668  [46]
 LDCM0466  CL73 HEK-293T C145(0.97); C132(0.96); C185(0.85)  LDD1669  [46]
 LDCM0467  CL74 HEK-293T C145(1.04); C132(1.12); C185(0.93)  LDD1670  [46]
 LDCM0469  CL76 HEK-293T C145(0.95); C132(1.02); C185(0.77)  LDD1672  [46]
 LDCM0470  CL77 HEK-293T C145(0.78); C132(1.01); C185(0.78)  LDD1673  [46]
 LDCM0471  CL78 HEK-293T C145(1.01); C132(0.93); C185(0.83)  LDD1674  [46]
 LDCM0472  CL79 HEK-293T C145(1.13); C132(0.89); C185(0.97)  LDD1675  [46]
 LDCM0473  CL8 HEK-293T C145(0.86); C132(0.70); C185(0.70)  LDD1676  [46]
 LDCM0474  CL80 HEK-293T C145(1.18); C132(0.77); C185(0.96)  LDD1677  [46]
 LDCM0475  CL81 HEK-293T C145(1.12); C132(0.81); C185(0.87)  LDD1678  [46]
 LDCM0476  CL82 HEK-293T C145(1.22); C132(0.79); C185(0.99)  LDD1679  [46]
 LDCM0477  CL83 HEK-293T C145(1.19); C132(0.62); C185(0.93)  LDD1680  [46]
 LDCM0478  CL84 HEK-293T C145(1.23); C132(0.69); C185(0.94)  LDD1681  [46]
 LDCM0479  CL85 HEK-293T C145(1.05); C132(0.99); C185(0.86)  LDD1682  [46]
 LDCM0480  CL86 HEK-293T C145(1.07); C132(1.19); C185(0.87)  LDD1683  [46]
 LDCM0481  CL87 HEK-293T C145(1.13); C132(1.18); C185(0.82)  LDD1684  [46]
 LDCM0482  CL88 HEK-293T C145(0.97); C132(1.10); C185(0.74)  LDD1685  [46]
 LDCM0483  CL89 HEK-293T C145(0.89); C132(1.04); C185(0.80)  LDD1686  [46]
 LDCM0484  CL9 HEK-293T C145(1.02); C132(0.72); C185(0.78)  LDD1687  [46]
 LDCM0485  CL90 HEK-293T C145(0.80); C132(0.89); C185(0.65)  LDD1688  [46]
 LDCM0486  CL91 HEK-293T C145(1.10); C132(0.93); C185(0.78)  LDD1689  [46]
 LDCM0487  CL92 HEK-293T C145(1.03); C132(0.86); C185(0.88)  LDD1690  [46]
 LDCM0488  CL93 HEK-293T C145(1.10); C132(0.85); C185(0.82)  LDD1691  [46]
 LDCM0489  CL94 HEK-293T C145(1.16); C132(0.90); C185(0.91)  LDD1692  [46]
 LDCM0490  CL95 HEK-293T C145(0.86); C132(0.72); C185(0.73)  LDD1693  [46]
 LDCM0491  CL96 HEK-293T C145(1.15); C132(0.92); C185(0.84)  LDD1694  [46]
 LDCM0492  CL97 HEK-293T C145(0.87); C132(0.90); C185(0.76)  LDD1695  [46]
 LDCM0493  CL98 HEK-293T C145(0.94); C132(1.07); C185(1.00)  LDD1696  [46]
 LDCM0494  CL99 HEK-293T C145(0.99); C132(1.14); C185(1.00)  LDD1697  [46]
 LDCM0634  CY-0357 Hep-G2 C145(1.39); C132(1.38)  LDD2228  [28]
 LDCM0495  E2913 HEK-293T C145(0.99); C132(1.06); C185(1.02)  LDD1698  [46]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C145(0.99); C184(0.85)  LDD1702  [45]
 LDCM0175  Ethacrynic acid HeLa C132(1.08); C132(0.97)  LDD2210  [15]
 LDCM0625  F8 Ramos C145(0.58); 1.28; C132(0.95); C205(0.36)  LDD2187  [48]
 LDCM0572  Fragment10 MDA-MB-231 C132(5.58)  LDD1465  [49]
 LDCM0573  Fragment11 MDA-MB-231 C132(0.92)  LDD1467  [49]
 LDCM0574  Fragment12 MDA-MB-231 C132(7.46)  LDD1468  [49]
 LDCM0575  Fragment13 MDA-MB-231 C132(1.09)  LDD1469  [49]
 LDCM0576  Fragment14 MDA-MB-231 C132(1.28)  LDD1471  [49]
 LDCM0579  Fragment20 Ramos C145(0.51); 0.68; C132(1.05); C205(0.17)  LDD2194  [48]
 LDCM0580  Fragment21 MDA-MB-231 C132(1.37)  LDD1473  [49]
 LDCM0582  Fragment23 Ramos C145(0.55); 0.15; C132(0.90); C205(0.43)  LDD2196  [48]
 LDCM0578  Fragment27 MDA-MB-231 C132(0.91)  LDD1474  [49]
 LDCM0586  Fragment28 MDA-MB-231 C132(1.00)  LDD1475  [49]
 LDCM0587  Fragment29 Ramos C132(1.21)  LDD1476  [49]
 LDCM0588  Fragment30 Ramos C145(1.14); 1.40; C132(1.12); C205(0.58)  LDD2199  [48]
 LDCM0589  Fragment31 MDA-MB-231 C132(0.85)  LDD1477  [49]
 LDCM0590  Fragment32 Ramos C145(0.55); 0.75; C132(1.55); C205(0.30)  LDD2201  [48]
 LDCM0468  Fragment33 MDA-MB-231 C132(1.34)  LDD1479  [49]
 LDCM0596  Fragment38 MDA-MB-231 C132(0.99)  LDD1480  [49]
 LDCM0566  Fragment4 MDA-MB-231 C132(3.84)  LDD1461  [49]
 LDCM0599  Fragment41 MDA-MB-231 C132(0.86)  LDD1481  [49]
 LDCM0603  Fragment45 MDA-MB-231 C132(9.25)  LDD1482  [49]
 LDCM0427  Fragment51 MDA-MB-231 C132(1.20)  LDD1483  [49]
 LDCM0610  Fragment52 Ramos C145(1.29); 2.21; C132(1.12); C205(0.56)  LDD2204  [48]
 LDCM0614  Fragment56 MDA-MB-231 C132(0.80)  LDD1484  [49]
 LDCM0569  Fragment7 Ramos C145(0.75); 0.71; C132(0.93); C205(0.21)  LDD2186  [48]
 LDCM0570  Fragment8 MDA-MB-231 C132(4.16)  LDD1462  [49]
 LDCM0571  Fragment9 MDA-MB-231 C132(1.35)  LDD1463  [49]
 LDCM0116  HHS-0101 DM93 Y135(0.79); Y230(0.88); Y280(0.88); Y138(0.90)  LDD0264  [18]
 LDCM0117  HHS-0201 DM93 Y280(0.78); Y380(0.80); Y449(0.83); Y323(0.83)  LDD0265  [18]
 LDCM0118  HHS-0301 DM93 Y230(0.46); Y280(0.75); Y449(0.75); Y72(0.79)  LDD0266  [18]
 LDCM0119  HHS-0401 DM93 Y230(0.77); Y280(0.88); Y449(0.89); Y380(0.89)  LDD0267  [18]
 LDCM0120  HHS-0701 DM93 Y380(0.76); Y449(0.77); Y323(0.81); Y230(0.84)  LDD0268  [18]
 LDCM0107  IAA HeLa H152(0.00); C184(0.00); H415(0.00); C145(0.00)  LDD0221  [34]
 LDCM0123  JWB131 DM93 Y135(0.81); Y138(1.08); Y280(0.91); Y323(0.99)  LDD0285  [17]
 LDCM0124  JWB142 DM93 Y135(0.54); Y138(0.81); Y280(0.54); Y323(0.85)  LDD0286  [17]
 LDCM0125  JWB146 DM93 Y135(0.85); Y138(1.53); Y280(1.03); Y323(1.06)  LDD0287  [17]
 LDCM0126  JWB150 DM93 Y135(2.53); Y138(4.27); Y280(2.81); Y323(2.17)  LDD0288  [17]
 LDCM0127  JWB152 DM93 Y135(1.39); Y138(1.87); Y280(1.89); Y323(1.69)  LDD0289  [17]
 LDCM0128  JWB198 DM93 Y135(1.10); Y138(1.20); Y280(1.08); Y323(1.14)  LDD0290  [17]
 LDCM0129  JWB202 DM93 Y135(0.44); Y138(1.71); Y280(0.36); Y323(0.66)  LDD0291  [17]
 LDCM0130  JWB211 DM93 Y135(0.86); Y138(1.52); Y280(0.91); Y323(1.07)  LDD0292  [17]
 LDCM0179  JZ128 PC-3 C145(0.00); C132(0.00)  LDD0462  [13]
 LDCM0022  KB02 MDA-MB-231 C132(4.97)  LDD1460  [49]
 LDCM0023  KB03 Jurkat C132(7.58); C145(4.48)  LDD0209  [16]
 LDCM0024  KB05 COLO792 C145(2.74)  LDD3310  [50]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C185(1.02); C184(1.01); C145(0.94)  LDD2102  [45]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C185(0.99); C184(1.30); C205(0.86); C145(0.93)  LDD2121  [45]
 LDCM0109  NEM HeLa H152(0.00); C145(0.00); C184(0.00); C185(0.00)  LDD0223  [34]
 LDCM0496  Nucleophilic fragment 11a MDA-MB-231 C185(1.38); C184(1.30); C205(0.74)  LDD2089  [45]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C185(1.06); C184(1.02); C205(1.19); C145(1.07)  LDD2090  [45]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C185(1.00); C184(0.96); C205(1.22); C145(1.22)  LDD2092  [45]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C184(1.00); C205(1.02); C145(1.15)  LDD2093  [45]
 LDCM0501  Nucleophilic fragment 13b MDA-MB-231 C185(1.82); C184(1.69); C205(2.14)  LDD2094  [45]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C205(0.11)  LDD2096  [45]
 LDCM0504  Nucleophilic fragment 15a MDA-MB-231 C185(1.14); C184(0.84); C205(1.19)  LDD2097  [45]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C185(1.12); C184(0.89); C205(0.85); C145(0.98)  LDD2098  [45]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C185(1.13); C184(1.12); C205(1.41); C145(1.40)  LDD2099  [45]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C185(0.99); C184(0.76); C205(0.46); C145(0.47)  LDD2100  [45]
 LDCM0508  Nucleophilic fragment 17a MDA-MB-231 C185(1.01); C184(0.98); C205(0.89); C145(1.05)  LDD2101  [45]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C185(0.76); C184(0.68); C205(0.45); C145(0.51)  LDD2104  [45]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C185(2.04); C184(1.64); C205(1.54); C145(1.73)  LDD2105  [45]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C185(0.64); C145(0.49)  LDD2106  [45]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C185(0.96); C184(1.02); C205(1.24); C145(1.22)  LDD2107  [45]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C185(0.77); C184(0.62); C205(0.52); C145(0.67)  LDD2108  [45]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C185(0.63); C184(0.61); C205(0.46); C145(0.97)  LDD2109  [45]
 LDCM0517  Nucleophilic fragment 21b MDA-MB-231 C185(1.03); C184(1.01); C205(0.60); C145(0.70)  LDD2110  [45]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C184(1.03); C205(1.12)  LDD2111  [45]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C185(0.89); C184(0.67); C145(0.60)  LDD2114  [45]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C185(0.43); C184(0.51); C205(0.43)  LDD2115  [45]
 LDCM0523  Nucleophilic fragment 24b MDA-MB-231 C205(0.29)  LDD2116  [45]
 LDCM0525  Nucleophilic fragment 25b MDA-MB-231 C184(0.18); C205(0.27)  LDD2118  [45]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C184(1.30); C205(1.99); C145(1.43)  LDD2119  [45]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C185(0.92); C184(0.79); C205(0.47); C145(0.90)  LDD2120  [45]
 LDCM0529  Nucleophilic fragment 27b MDA-MB-231 C205(0.16); C145(0.37)  LDD2122  [45]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C185(0.78); C184(0.76); C145(1.08)  LDD2123  [45]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C185(0.11); C184(0.11); C205(0.16); C145(0.42)  LDD2124  [45]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C185(0.73); C184(0.76); C205(0.82); C145(1.03)  LDD2125  [45]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C205(0.16)  LDD2126  [45]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C185(0.84); C184(0.85); C205(1.03); C145(1.09)  LDD2127  [45]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C185(0.96); C184(0.78); C205(0.59); C145(1.03)  LDD2128  [45]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C184(0.86); C205(1.18)  LDD2129  [45]
 LDCM0540  Nucleophilic fragment 35 MDA-MB-231 C184(0.75); C205(0.46)  LDD2133  [45]
 LDCM0541  Nucleophilic fragment 36 MDA-MB-231 C185(0.59); C184(0.62); C205(0.46)  LDD2134  [45]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C184(0.83); C205(1.47); C145(1.82)  LDD2135  [45]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C185(1.32); C184(1.16); C205(1.16)  LDD2136  [45]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C185(0.74); C184(0.84); C205(0.96); C145(0.95)  LDD2137  [45]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C145(2.95); C205(2.61); C184(1.77)  LDD1700  [45]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C184(0.97); C205(0.82); C145(1.16)  LDD2140  [45]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C185(0.68); C184(0.62); C205(0.56); C145(1.01)  LDD2141  [45]
 LDCM0549  Nucleophilic fragment 43 MDA-MB-231 C185(0.92); C184(0.82); C205(0.51); C145(1.05)  LDD2143  [45]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C184(1.93); C205(2.33); C145(1.84)  LDD2144  [45]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C185(8.16); C205(1.72); C145(5.62)  LDD2145  [45]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C184(0.99); C205(0.93)  LDD2146  [45]
 LDCM0553  Nucleophilic fragment 6b MDA-MB-231 C185(2.52); C184(2.46); C205(1.83); C145(2.69)  LDD2147  [45]
 LDCM0554  Nucleophilic fragment 7a MDA-MB-231 C185(0.48); C184(0.60); C205(0.36); C145(0.53)  LDD2148  [45]
 LDCM0555  Nucleophilic fragment 7b MDA-MB-231 C205(0.18)  LDD2149  [45]
 LDCM0556  Nucleophilic fragment 8a MDA-MB-231 C185(1.33); C184(1.11); C205(0.48)  LDD2150  [45]
 LDCM0557  Nucleophilic fragment 8b MDA-MB-231 C184(0.16); C205(0.19)  LDD2151  [45]
 LDCM0559  Nucleophilic fragment 9b MDA-MB-231 C185(2.62); C184(2.25); C205(1.95); C145(1.61)  LDD2153  [45]
 LDCM0627  NUDT7-COV-1 HEK-293T C132(0.97); C132(0.89)  LDD2206  [51]
 LDCM0628  OTUB2-COV-1 HEK-293T C132(1.21); C184(1.11); C184(0.97); C145(0.85)  LDD2207  [51]
 LDCM0131  RA190 MM1.R C132(1.94); C184(1.51); C185(1.51); C145(1.47)  LDD0304  [52]
 LDCM0021  THZ1 HeLa S3 C145(1.09); C132(1.04)  LDD0460  [13]
 LDCM0112  W16 Hep-G2 R201(1.12)  LDD0239  [35]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paraplegin (SPG7) AAA ATPase family; Peptidase M41 family Q9UQ90
Ethanolamine kinase 2 (ETNK2) Choline/ethanolamine kinase family Q9NVF9
Protein arginine N-methyltransferase 1 (PRMT1) Protein arginine N-methyltransferase family Q99873
NADH dehydrogenase flavoprotein 2, mitochondrial (NDUFV2) Complex I 24 kDa subunit family P19404
Dopamine beta-hydroxylase (DBH) Copper type II ascorbate-dependent monooxygenase family P09172
C->U-editing enzyme APOBEC-1 (APOBEC1) Cytidine and deoxycytidylate deaminase family P41238
DNA dC->dU-editing enzyme APOBEC-3C (APOBEC3C) Cytidine and deoxycytidylate deaminase family Q9NRW3
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Nitric oxide synthase 3 (NOS3) NOS family P29474
Aurora kinase A (AURKA) Ser/Thr protein kinase family O14965
Dual specificity mitogen-activated protein kinase kinase 2 (MAP2K2) STE Ser/Thr protein kinase family P36507
Non-receptor tyrosine-protein kinase TYK2 (TYK2) Tyr protein kinase family P29597
Proto-oncogene tyrosine-protein kinase Src (SRC) Tyr protein kinase family P12931
Dexamethasone-induced Ras-related protein 1 (RASD1) RasD family Q9Y272
Post-GPI attachment to proteins factor 6 (PGAP6) TMEM8 family Q9HCN3
Interferon-inducible GTPase 5 (IRGC) IRG family Q6NXR0
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Transporter and channel
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Metal transporter CNNM3 (CNNM3) ACDP family Q8NE01
Huntingtin (HTT) Huntingtin family P42858
Junctophilin-3 (JPH3) Junctophilin family Q8WXH2
Aquaporin-5 (AQP5) MIP/aquaporin (TC 1.A.8) family P55064
Cellular tumor antigen p53 (TP53) P53 family P04637
Transcription factor
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Krueppel-like factor 1 (KLF1) Krueppel C2H2-type zinc-finger protein family Q13351
Zinc finger protein 526 (ZNF526) Krueppel C2H2-type zinc-finger protein family Q8TF50
Zinc finger protein 575 (ZNF575) Krueppel C2H2-type zinc-finger protein family Q86XF7
Zinc finger protein 792 (ZNF792) Krueppel C2H2-type zinc-finger protein family Q3KQV3
Tumor protein 63 (TP63) P53 family Q9H3D4
Telomeric repeat-binding factor 2-interacting protein 1 (TERF2IP) RAP1 family Q9NYB0
Forkhead box protein D4-like 1 (FOXD4L1) . Q9NU39
Forkhead box protein D4-like 3 (FOXD4L3) . Q6VB84
Homeobox protein notochord (NOTO) . A8MTQ0
Myb-related transcription factor, partner of profilin (MYPOP) . Q86VE0
Transcription factor 23 (TCF23) . Q7RTU1
Zinc finger protein 408 (ZNF408) . Q9H9D4
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-2 adrenergic receptor (ADRB2) G-protein coupled receptor 1 family P07550
Other
Click To Hide/Show 43 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Abl interactor 2 (ABI2) ABI family Q9NYB9
Ataxin-10 (ATXN10) Ataxin-10 family Q9UBB4
Large ribosomal subunit protein bL9m (MRPL9) Bacterial ribosomal protein bL9 family Q9BYD2
Dedicator of cytokinesis protein 2 (DOCK2) DOCK family Q92608
Hemoglobin subunit zeta (HBZ) Globin family P02008
Growth factor receptor-bound protein 2 (GRB2) GRB2/sem-5/DRK family P62993
Glial fibrillary acidic protein (GFAP) Intermediate filament family P14136
KH domain-containing, RNA-binding, signal transduction-associated protein 1 (KHDRBS1) KHDRBS family Q07666
KH domain-containing, RNA-binding, signal transduction-associated protein 2 (KHDRBS2) KHDRBS family Q5VWX1
KH domain-containing, RNA-binding, signal transduction-associated protein 3 (KHDRBS3) KHDRBS family O75525
Mitotic interactor and substrate of PLK1 (MISP) MISP family Q8IVT2
Neural proliferation differentiation and control protein 1 (NPDC1) NPDC1/cab-1 family Q9NQX5
U4/U6 small nuclear ribonucleoprotein Prp31 (PRPF31) PRP31 family Q8WWY3
RNA guanine-N7 methyltransferase activating subunit (RAMAC) RAM family Q9BTL3
RNA-binding protein 42 (RBM42) RRM RBM42 family Q9BTD8
U1 small nuclear ribonucleoprotein A (SNRPA) RRM U1 A/B'' family P09012
Serine/arginine-rich splicing factor 3 (SRSF3) Splicing factor SR family P84103
Splicing factor U2AF 35 kDa subunit (U2AF1) Splicing factor SR family Q01081
BTB/POZ domain-containing protein KCTD8 (KCTD8) . Q6ZWB6
Cold-inducible RNA-binding protein (CIRBP) . Q14011
DALR anticodon-binding domain-containing protein 3 (DALRD3) . Q5D0E6
Heterogeneous nuclear ribonucleoprotein K (HNRNPK) . P61978
Heterogeneous nuclear ribonucleoprotein L (HNRNPL) . P14866
Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) . Q8WVV9
Heterogeneous nuclear ribonucleoprotein U (HNRNPU) . Q00839
KH domain-containing RNA-binding protein QKI (QKI) . Q96PU8
Matrin-3 (MATR3) . P43243
Proline-rich protein 3 (PRR3) . P79522
Protocadherin beta-14 (PCDHB14) . Q9Y5E9
Rab effector Noc2 (RPH3AL) . Q9UNE2
RAS protein activator like-3 (RASAL3) . Q86YV0
Receptor-transporting protein 5 (RTP5) . Q14D33
RNA-binding motif protein, X chromosome (RBMX) . P38159
RNA-binding motif protein, Y chromosome, family 1 member A1 (RBMY1A1) . P0DJD3
RNA-binding motif protein, Y chromosome, family 1 member F/J (RBMY1F; RBMY1J) . Q15415
RNA-binding protein 14 (RBM14) . Q96PK6
RNA-binding protein 3 (RBM3) . P98179
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
TAR DNA-binding protein 43 (TARDBP) . Q13148
Uncharacterized protein C6orf226 (C6orf226) . Q5I0X4
Vinexin (SORBS3) . O60504
YTH domain-containing protein 1 (YTHDC1) . Q96MU7
Zinc finger protein 385C (ZNF385C) . Q66K41

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Artenimol . DB11638
Investigative
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Phenethyl Isothiocyanate Small molecular drug DB12695

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Comparison of Different Competitive Proteome Profiling Approaches in Target Identification of Covalent Inhibitors. Chembiochem. 2022 Dec 16;23(24):e202200389. doi: 10.1002/cbic.202200389. Epub 2022 Nov 22.
3 2-Ethynylbenzaldehyde-Based, Lysine-Targeting Irreversible Covalent Inhibitors for Protein Kinases and Nonkinases. J Am Chem Soc. 2023 Feb 12. doi: 10.1021/jacs.2c11595. Online ahead of print.
Mass spectrometry data entry: PXD037665
4 A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3.
Mass spectrometry data entry: PXD014175
5 Small-Molecule Activity-Based Probe for Monitoring Ubiquitin C-Terminal Hydrolase L1 (UCHL1) Activity in Live Cells and Zebrafish Embryos. J Am Chem Soc. 2020 Sep 30;142(39):16825-16841. doi: 10.1021/jacs.0c07726. Epub 2020 Sep 18.
Mass spectrometry data entry: PXD021557 , PXD015828
6 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
7 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
8 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
9 2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells. J Am Chem Soc. 2020 Apr 1;142(13):6051-6059. doi: 10.1021/jacs.9b12116. Epub 2020 Mar 23.
10 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
11 A chemical proteomics approach for global mapping of functional lysines on cell surface of living cell. Nat Commun. 2024 Apr 8;15(1):2997. doi: 10.1038/s41467-024-47033-w.
Mass spectrometry data entry: PXD042888
12 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
13 A Chemoproteomic Strategy for Direct and Proteome-Wide Covalent Inhibitor Target-Site Identification. J Am Chem Soc. 2019 Jan 9;141(1):191-203. doi: 10.1021/jacs.8b07911. Epub 2018 Dec 20.
14 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
15 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
16 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
17 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
18 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
19 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
20 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
21 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
22 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
23 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
24 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
25 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
26 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
27 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
28 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
29 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
30 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
31 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
32 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
33 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
34 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
35 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
36 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
37 Differently Tagged Probes for Protein Profiling of Mitochondria. Chembiochem. 2019 May 2;20(9):1155-1160. doi: 10.1002/cbic.201800735. Epub 2019 Mar 26.
38 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
39 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
40 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
41 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
42 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
43 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
44 Proteome profiling reveals potential cellular targets of staurosporine using a clickable cell-permeable probe. Chem Commun (Camb). 2011 Oct 28;47(40):11306-8. doi: 10.1039/c1cc14824a. Epub 2011 Sep 16.
45 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
46 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
47 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
48 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
49 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
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Mass spectrometry data entry: PXD047840
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