Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name IA-alkyne  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
Isotope tag
Competitor Name Fragment51  Competitor Info 
Competitor Concentration 200 uM
In Vivo Experiment Model Model Type Living cell
Derived Tissue Breast
Disease Model Breast adenocarcinoma [ICD-11:2C60]
Model Name Human breast adenocarcinoma cells (MDA-MB-231)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 45 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP02055  Thymidylate synthase (TYMS) C199 20.0
 LDTP02502  Thioredoxin (TXN) C32 13.9
 LDTP03859  V-type proton ATPase catalytic subunit A (ATP6V1A) C138 10.6
 LDTP03521  Protein disulfide-isomerase A3 (PDIA3) C406 6.0
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C555 6.0
 LDTP03163  Sterol carrier protein 2 (SCP2) C71 5.6
 LDTP02677  Protein disulfide-isomerase A4 (PDIA4) C206 5.3
 LDTP10973  Thioredoxin, mitochondrial (TXN2) C90 5.0
 LDTP06314  Protein disulfide-isomerase A6 (PDIA6) C55 5.0
 LDTP03316  DNA replication licensing factor MCM3 (MCM3) C119 2.6
 LDTP14888  Pre-rRNA-processing protein TSR1 homolog (TSR1) C126 1.9
 LDTP10386  ERO1-like protein alpha (ERO1A) C241 1.7
 LDTP11111  Tudor-interacting repair regulator protein (NUDT16L1) C88 1.6
 LDTP05912  Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 (PIN1) C113 1.4
 LDTP10878  Parkinson disease protein 7 (PARK7) C106 1.4
 LDTP04690  Double-stranded RNA-specific adenosine deaminase (ADAR) C1224 1.3
 LDTP12313  Putative bifunctional UDP-N-acetylglucosamine transferase and deubiquitinase ALG13 (ALG13) C86 1.3
 LDTP15290  5'-nucleotidase domain-containing protein 3 (NT5DC3) C276 1.2
 LDTP11059  ADP-ribose glycohydrolase MACROD1 (MACROD1) C186 1.2
 LDTP18330  Haloacid dehalogenase-like hydrolase domain-containing 5 (HDHD5) C392 1.1
 LDTP03998  3-ketoacyl-CoA thiolase, mitochondrial (ACAA2) C92 1.1
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C413 1.1
 LDTP07407  Desumoylating isopeptidase 1 (DESI1) C108 1.1
 LDTP06643  Uridine phosphorylase 1 (UPP1) C162 1.1
 LDTP04374  Dynamin-2 (DNM2) C27 1.1
 LDTP00601  UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT) C758 1.1
 LDTP03770  Alpha-adducin (ADD1) C68 1.0
 LDTP02611  Inosine-5'-monophosphate dehydrogenase 2 (IMPDH2) C140 1.0
 LDTP01245  Enoyl-CoA delta isomerase 2 (ECI2) C380 1.0
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C223 1.0
 LDTP08181  Glutaredoxin-related protein 5, mitochondrial (GLRX5) C67 1.0
 LDTP03146  Protein-glutamine gamma-glutamyltransferase 2 (TGM2) C277 1.0
 LDTP02038  Glyceraldehyde-3-phosphate dehydrogenase (GAPDH) C152 1.0
 LDTP12227  Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (MCCC2) C216 0.9
 LDTP01055  6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 2 (PFKFB2) C158 0.9
 LDTP02765  Aldo-keto reductase family 1 member B1 (AKR1B1) C299 0.9
 LDTP03496  Protein PML (PML) C389 0.9
 LDTP10801  ATPase WRNIP1 (WRNIP1) C272 0.9
 LDTP18123  Isochorismatase domain-containing protein 2 (ISOC2) C114 0.8
 LDTP05859  Integrin-linked protein kinase (ILK) C346 0.8
 LDTP02552  Glycogen phosphorylase, brain form (PYGB) C326 0.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C207 0.7
 LDTP02022  Thymidine kinase, cytosolic (TK1) C230 0.7
 LDTP03291  Acetyl-CoA acetyltransferase, mitochondrial (ACAT1) C119 0.7
 LDTP12428  Omega-amidase NIT2 (NIT2) C153 0.6
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP14222  Chloride intracellular channel protein 4 (CLIC4) C35 2.6
 LDTP04801  Gasdermin-D (GSDMD) C268 1.8
 LDTP08315  THO complex subunit 6 homolog (THOC6) C35 1.4
 LDTP05591  Nuclear cap-binding protein subunit 1 (NCBP1) C44 1.2
 LDTP00501  Exportin-1 (XPO1) C528 1.1
Transcription factor
Click to Show/Hide to Show 4 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03969  Signal transducer and activator of transcription 1-alpha/beta (STAT1) C492 2.4
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 1.6
 LDTP09311  SWI/SNF complex subunit SMARCC2 (SMARCC2) C145 1.2
 LDTP12507  Chromatin accessibility complex protein 1 (CHRAC1) C55 1.1
Other
Click to Show/Hide to Show 42 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP13979  Cytosolic iron-sulfur assembly component 2B (CIAO2B) C93 20.0
 LDTP10299  Enhancer of mRNA-decapping protein 3 (EDC3) C413 20.0
 LDTP14217  Lipid droplet-regulating VLDL assembly factor AUP1 (AUP1) C391 20.0
 LDTP06250  Proteasome activator complex subunit 4 (PSME4) C1840 20.0
 LDTP06378  Disks large-associated protein 5 (DLGAP5) C129 7.4
 LDTP09626  Heterogeneous nuclear ribonucleoprotein L-like (HNRNPLL) C464 3.2
 LDTP12800  Serine/threonine-protein phosphatase 4 regulatory subunit 2 (PPP4R2) C22 2.2
 LDTP12651  TBC1 domain family member 23 (TBC1D23) C283 2.1
 LDTP10771  Mediator of RNA polymerase II transcription subunit 15 (MED15) C618 2.1
 LDTP12571  LanC-like protein 2 (LANCL2) C187 2.0
 LDTP13622  NFU1 iron-sulfur cluster scaffold homolog, mitochondrial (NFU1) C213 1.8
 LDTP06684  Sister chromatid cohesion protein PDS5 homolog A (PDS5A) C242 1.8
 LDTP07088  Formin-binding protein 1-like (FNBP1L) C69 1.7
 LDTP08018  Zinc finger CCCH-type antiviral protein 1 (ZC3HAV1) C645 1.6
 LDTP13583  Targeting protein for Xklp2 (TPX2) C536 1.4
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C561 1.3
 LDTP04514  Heterogeneous nuclear ribonucleoprotein F (HNRNPF) C267 1.3
 LDTP03615  Heterogeneous nuclear ribonucleoprotein H (HNRNPH1) C267 1.3
 LDTP00463  Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3) C343 1.3
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C341 1.2
 LDTP03967  Lamina-associated polypeptide 2, isoform alpha (TMPO) C684 1.2
 LDTP04952  Heterogeneous nuclear ribonucleoprotein K (HNRNPK) C132 1.2
 LDTP12412  Reticulon-4 (RTN4) C1101 1.2
 LDTP06276  MAD2L1-binding protein (MAD2L1BP) C124 1.2
 LDTP11191  WW domain-containing adapter protein with coiled-coil (WAC) C553 1.2
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C23 1.2
 LDTP15701  EF-hand domain-containing protein D2 (EFHD2) C172 1.2
 LDTP05770  Aminoacyl tRNA synthase complex-interacting multifunctional protein 2 (AIMP2) C291 1.1
 LDTP05867  Treacle protein (TCOF1) C38 1.1
 LDTP13580  Coronin-1C (CORO1C) C420 1.1
 LDTP04078  Proliferation marker protein Ki-67 (MKI67) C903 1.1
 LDTP06281  Condensin complex subunit 1 (NCAPD2) C439 1.1
 LDTP13402  Dynactin subunit 4 (DCTN4) C258 1.1
 LDTP12753  Succinate dehydrogenase assembly factor 2, mitochondrial (SDHAF2) C83 1.0
 LDTP14215  Small ribosomal subunit protein mS40 (MRPS18B) C128 1.0
 LDTP15896  Ashwin (C2orf49) C10 1.0
 LDTP01532  ZW10 interactor (ZWINT) C54 1.0
 LDTP05021  Large ribosomal subunit protein eL30 (RPL30) C92 0.9
 LDTP04201  T-complex protein 1 subunit epsilon (CCT5) C253 0.8
 LDTP18494  Tropomodulin-3 (TMOD3) C132 0.8
 LDTP04487  Cyclin-H (CCNH) C244 0.7
 LDTP06366  Poly(rC)-binding protein 1 (PCBP1) C194 0.6

References

1 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.