Details of the Target

General Information of Target

Target ID LDTP09962
Target Name Ubiquitin carboxyl-terminal hydrolase 7 (USP7)
Gene Name USP7
Gene ID 7874
Synonyms
HAUSP; Ubiquitin carboxyl-terminal hydrolase 7; EC 3.4.19.12; Deubiquitinating enzyme 7; Herpesvirus-associated ubiquitin-specific protease; Ubiquitin thioesterase 7; Ubiquitin-specific-processing protease 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTATTRGSPVGGNDNQGQAPDGQSQPPLQQNQTSSPDSSNENSPATPPDEQGQGDAPPQL
EDEEPAFPHTDLAKLDDMINRPRWVVPVLPKGELEVLLEAAIDLSKKGLDVKSEACQRFF
RDGLTISFTKILTDEAVSGWKFEIHRCIINNTHRLVELCVAKLSQDWFPLLELLAMALNP
HCKFHIYNGTRPCESVSSSVQLPEDELFARSPDPRSPKGWLVDLLNKFGTLNGFQILHDR
FINGSALNVQIIAALIKPFGQCYEFLTLHTVKKYFLPIIEMVPQFLENLTDEELKKEAKN
EAKNDALSMIIKSLKNLASRVPGQEETVKNLEIFRLKMILRLLQISSFNGKMNALNEVNK
VISSVSYYTHRHGNPEEEEWLTAERMAEWIQQNNILSIVLRDSLHQPQYVEKLEKILRFV
IKEKALTLQDLDNIWAAQAGKHEAIVKNVHDLLAKLAWDFSPEQLDHLFDCFKASWTNAS
KKQREKLLELIRRLAEDDKDGVMAHKVLNLLWNLAHSDDVPVDIMDLALSAHIKILDYSC
SQDRDTQKIQWIDRFIEELRTNDKWVIPALKQIREICSLFGEAPQNLSQTQRSPHVFYRH
DLINQLQHNHALVTLVAENLATYMESMRLYARDHEDYDPQTVRLGSRYSHVQEVQERLNF
LRFLLKDGQLWLCAPQAKQIWKCLAENAVYLCDREACFKWYSKLMGDEPDLDPDINKDFF
ESNVLQLDPSLLTENGMKCFERFFKAVNCREGKLVAKRRAYMMDDLELIGLDYLWRVVIQ
SNDDIASRAIDLLKEIYTNLGPRLQVNQVVIHEDFIQSCFDRLKASYDTLCVLDGDKDSV
NCARQEAVRMVRVLTVLREYINECDSDYHEERTILPMSRAFRGKHLSFVVRFPNQGRQVD
DLEVWSHTNDTIGSVRRCILNRIKANVAHTKIELFVGGELIDPADDRKLIGQLNLKDKSL
ITAKLTQISSNMPSSPDSSSDSSTGSPGNHGNHYSDGPNPEVESCLPGVIMSLHPRYISF
LWQVADLGSSLNMPPLRDGARVLMKLMPPDSTTIEKLRAICLDHAKLGESSLSPSLDSLF
FGPSASQVLYLTEVVYALLMPAGAPLADDSSDFQFHFLKSGGLPLVLSMLTRNNFLPNAD
METRRGAYLNALKIAKLLLTAIGYGHVRAVAEACQPGVEGVNPMTQINQVTHDQAVVLQS
ALQSIPNPSSECMLRNVSVRLAQQISDEASRYMPDICVIRAIQKIIWASGCGSLQLVFSP
NEEITKIYEKTNAGNEPDLEDEQVCCEALEVMTLCFALIPTALDALSKEKAWQTFIIDLL
LHCHSKTVRQVAQEQFFLMCTRCCMGHRPLLFFITLLFTVLGSTARERAKHSGDYFTLLR
HLLNYAYNSNINVPNAEVLLNNEIDWLKRIRDDVKRTGETGIEETILEGHLGVTKELLAF
QTSEKKFHIGCEKGGANLIKELIDDFIFPASNVYLQYMRNGELPAEQAIPVCGSPPTINA
GFELLVALAVGCVRNLKQIVDSLTEMYYIGTAITTCEALTEWEYLPPVGPRPPKGFVGLK
NAGATCYMNSVIQQLYMIPSIRNGILAIEGTGSDVDDDMSGDEKQDNESNVDPRDDVFGY
PQQFEDKPALSKTEDRKEYNIGVLRHLQVIFGHLAASRLQYYVPRGFWKQFRLWGEPVNL
REQHDALEFFNSLVDSLDEALKALGHPAMLSKVLGGSFADQKICQGCPHRYECEESFTTL
NVDIRNHQNLLDSLEQYVKGDLLEGANAYHCEKCNKKVDTVKRLLIKKLPPVLAIQLKRF
DYDWERECAIKFNDYFEFPRELDMEPYTVAGVAKLEGDNVNPESQLIQQSEQSESETAGS
TKYRLVGVLVHSGQASGGHYYSYIIQRNGGDGERNRWYKFDDGDVTECKMDDDEEMKNQC
FGGEYMGEVFDHMMKRMSYRRQKRWWNAYILFYERMDTIDQDDELIRYISELAITTRPHQ
IIMPSAIERSVRKQNVQFMHNRMQYSMEYFQFMKKLLTCNGVYLNPPPGQDHLLPEAEEI
TMISIQLAARFLFTTGFHTKKVVRGSASDWYDALCILLRHSKNVRFWFAHNVLFNVSNRF
SEYLLECPSAEVRGAFAKLIVFIAHFSLQDGPCPSPFASPGPSSQAYDNLSLSDHLLRAV
LNLLRREVSEHGRHLQQYFNLFVMYANLGVAEKTQLLKLSVPATFMLVSLDEGPGPPIKY
QYAELGKLYSVVSQLIRCCNVSSRMQSSINGNPPLPNPFGDPNLSQPIMPIQQNVADILF
VRTSYVKKIIEDCSNSEETVKLLRFCCWENPQFSSTVLSELLWQVAYSYTYELRPYLDLL
LQILLIEDSWQTHRIHNALKGIPDDRDGLFDTIQRSKNHYQKRAYQCIKCMVALFSNCPV
AYQILQGNGDLKRKWTWAVEWLGDELERRPYTGNPQYTYNNWSPPVQSNETSNGYFLERS
HSARMTLAKACELCPEEEPDDQDAPDEHESPPPEDAPLYPHSPGSQYQQNNHVHGQPYTG
PAAHHMNNPQRTGQRAQENYEGSEEVSPPQTKDQ
Target Type
Preclinical
Target Bioclass
Enzyme
Family
Peptidase C19 family
Subcellular location
Nucleus
Function
Hydrolase that deubiquitinates target proteins such as FOXO4, DEPTOR, KAT5, p53/TP53, MDM2, ERCC6, DNMT1, UHRF1, PTEN, KMT2E/MLL5 and DAXX. Together with DAXX, prevents MDM2 self-ubiquitination and enhances the E3 ligase activity of MDM2 towards p53/TP53, thereby promoting p53/TP53 ubiquitination and proteasomal degradation. Deubiquitinates p53/TP53, preventing degradation of p53/TP53, and enhances p53/TP53-dependent transcription regulation, cell growth repression and apoptosis. Deubiquitinates p53/TP53 and MDM2 and strongly stabilizes p53/TP53 even in the presence of excess MDM2, and also induces p53/TP53-dependent cell growth repression and apoptosis. Deubiquitination of FOXO4 in presence of hydrogen peroxide is not dependent on p53/TP53 and inhibits FOXO4-induced transcriptional activity. In association with DAXX, is involved in the deubiquitination and translocation of PTEN from the nucleus to the cytoplasm, both processes that are counteracted by PML. Deubiquitinates KMT2E/MLL5 preventing KMT2E/MLL5 proteasomal-mediated degradation. Involved in cell proliferation during early embryonic development. Involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage: recruited to DNA damage sites following interaction with KIAA1530/UVSSA and promotes deubiquitination of ERCC6, preventing UV-induced degradation of ERCC6. Involved in maintenance of DNA methylation via its interaction with UHRF1 and DNMT1: acts by mediating deubiquitination of UHRF1 and DNMT1, preventing their degradation and promoting DNA methylation by DNMT1. Deubiquitinates alkylation repair enzyme ALKBH3. OTUD4 recruits USP7 and USP9X to stabilize ALKBH3, thereby promoting the repair of alkylated DNA lesions. Acts as a chromatin regulator via its association with the Polycomb group (PcG) multiprotein PRC1-like complex; may act by deubiquitinating components of the PRC1-like complex. Able to mediate deubiquitination of histone H2B; it is however unsure whether this activity takes place in vivo. Exhibits a preference towards 'Lys-48'-linked ubiquitin chains. Increases regulatory T-cells (Treg) suppressive capacity by deubiquitinating and stabilizing the transcription factor FOXP3 which is crucial for Treg cell function. Plays a role in the maintenance of the circadian clock periodicity via deubiquitination and stabilization of the CRY1 and CRY2 proteins. Deubiquitinates REST, thereby stabilizing REST and promoting the maintenance of neural progenitor cells. Deubiquitinates SIRT7, inhibiting SIRT7 histone deacetylase activity and regulating gluconeogenesis. Involved in the regulation of WASH-dependent actin polymerization at the surface of endosomes and the regulation of endosomal protein recycling. It maintains optimal WASH complex activity and precise F-actin levels via deubiquitination of TRIM27 and WASHC1. Mediates the deubiquitination of phosphorylated DEPTOR, promoting its stability and leading to decreased mTORC1 signaling.; (Microbial infection) Contributes to the overall stabilization and trans-activation capability of the herpesvirus 1 trans-acting transcriptional protein ICP0/VMW110 during HSV-1 infection.; (Microbial infection) Upon infection with Epstein-Barr virus, the interaction with viral EBNA1 increases the association of USP7 with PML proteins, which is required for the polyubiquitylation and degradation of PML.
TTD ID
T42658
Uniprot ID
Q93009
DrugMap ID
TTXU3EQ
Ensemble ID
ENST00000344836.9
HGNC ID
HGNC:12630
ChEMBL ID
CHEMBL2157850

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.A197V DBIA    Probe Info 
BICR22 SNV: p.E495V DBIA    Probe Info 
COLO792 SNV: p.P804L DBIA    Probe Info 
HCT15 SNV: p.A627S DBIA    Probe Info 
HSC3 SNV: p.H111Q DBIA    Probe Info 
JM1 SNV: p.T128M DBIA    Probe Info 
JURKAT Deletion: p.I1100SfsTer44 Compound 10    Probe Info 
MOLT4 SNV: p.R239Ter IA-alkyne    Probe Info 
NCIH146 SNV: p.R793C DBIA    Probe Info 
RKO SNV: p.L540F DBIA    Probe Info 
SHP77 SNV: p.M761L DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 39 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
W1
 Probe Info  		18.23  LDD0235  [3]
TH211
 Probe Info  		Y706(20.00); Y243(8.53)  LDD0257  [4]
1oxF11yne
 Probe Info  		N.A.  LDD0193  [5]
BTD
 Probe Info  		C315(15.34)  LDD1699  [6]
Probe 1
 Probe Info  		Y106(31.00); Y143(13.74); Y379(39.33); Y411(12.18)  LDD3495  [7]
AHL-Pu-1
 Probe Info  		C223(2.20); C300(2.69)  LDD0168  [8]
HHS-475
 Probe Info  		Y1091(2.91)  LDD0264  [9]
HHS-465
 Probe Info  		Y1091(2.81)  LDD2237  [10]
DBIA
 Probe Info  		C334(1.23); C961(1.49)  LDD0080  [11]
ATP probe
 Probe Info  		K914(0.00); K272(0.00); K277(0.00); K278(0.00)  LDD0199  [12]
4-Iodoacetamidophenylacetylene
 Probe Info  		C896(0.00); C488(0.00); C925(0.00); C721(0.00)  LDD0038  [13]
IA-alkyne
 Probe Info  		C961(0.00); C300(0.00); C925(0.00)  LDD0032  [14]
IPIAA_H
 Probe Info  		N.A.  LDD0030  [15]
IPIAA_L
 Probe Info  		C961(0.00); C300(0.00)  LDD0031  [15]
Lodoacetamide azide
 Probe Info  		C488(0.00); C925(0.00); C721(0.00); C917(0.00)  LDD0037  [13]
ATP probe
 Probe Info  		N.A.  LDD0035  [16]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [17]
NAIA_4
 Probe Info  		N.A.  LDD2226  [18]
TFBX
 Probe Info  		C90(0.00); C315(0.00)  LDD0027  [17]
WYneN
 Probe Info  		C315(0.00); C799(0.00)  LDD0021  [19]
WYneO
 Probe Info  		N.A.  LDD0022  [19]
aHNE
 Probe Info  		N.A.  LDD0001  [19]
1d-yne
 Probe Info  		N.A.  LDD0356  [20]
Compound 10
 Probe Info  		C315(0.00); C702(0.00); C711(0.00); C90(0.00)  LDD2216  [21]
Compound 11
 Probe Info  		C223(0.00); C315(0.00)  LDD2213  [21]
IPM
 Probe Info  		N.A.  LDD0005  [19]
PF-06672131
 Probe Info  		N.A.  LDD0017  [22]
SF
 Probe Info  		N.A.  LDD0028  [23]
STPyne
 Probe Info  		N.A.  LDD0009  [19]
VSF
 Probe Info  		C315(0.00); C961(0.00)  LDD0007  [19]
Phosphinate-6
 Probe Info  		C223(0.00); C315(0.00); C961(0.00)  LDD0018  [24]
Acrolein
 Probe Info  		C961(0.00); C799(0.00); H855(0.00); C721(0.00)  LDD0217  [25]
Crotonaldehyde
 Probe Info  		H855(0.00); C90(0.00); H1012(0.00)  LDD0219  [25]
Methacrolein
 Probe Info  		C90(0.00); C721(0.00)  LDD0218  [25]
AOyne
 Probe Info  		11.70  LDD0443  [26]
NAIA_5
 Probe Info  		C488(0.00); C925(0.00); C799(0.00); C917(0.00)  LDD2223  [18]
HHS-482
 Probe Info  		Y1091(1.47)  LDD2239  [10]
PAL-AfBPP Probe
Click To Hide/Show 10 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C249
 Probe Info  		13.45  LDD1922  [27]
C363
 Probe Info  		17.75  LDD2024  [27]
FFF probe11
 Probe Info  		5.47  LDD0472  [28]
FFF probe13
 Probe Info  		12.96  LDD0475  [28]
FFF probe14
 Probe Info  		12.04  LDD0477  [28]
FFF probe15
 Probe Info  		5.66  LDD0478  [28]
FFF probe2
 Probe Info  		6.07  LDD0463  [28]
FFF probe3
 Probe Info  		7.00  LDD0464  [28]
STS-2
 Probe Info  		1.00  LDD0139  [29]
OEA-DA
 Probe Info  		11.66  LDD0046  [30]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C315(1.00)  LDD2112  [6]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C315(1.05); C334(1.29)  LDD2117  [6]
 LDCM0510  3-(4-(Hydroxydiphenylmethyl)piperidin-1-yl)-3-oxopropanenitrile MDA-MB-231 C315(0.87)  LDD2103  [6]
 LDCM0025  4SU-RNA HEK-293T C223(2.20); C300(2.69)  LDD0168  [8]
 LDCM0026  4SU-RNA+native RNA HEK-293T C961(2.48); C315(2.08); C223(2.56)  LDD0169  [8]
 LDCM0561  Abegg_cp(-)-10 HeLa C702(2.40)  LDD0312  [17]
 LDCM0562  Abegg_cp(-)-11 HeLa C702(2.79)  LDD0313  [17]
 LDCM0214  AC1 HCT 116 C223(1.32); C315(1.26); C334(1.16); C721(1.07)  LDD0531  [11]
 LDCM0215  AC10 HCT 116 C315(1.19); C334(0.89); C721(0.81); C799(0.91)  LDD0532  [11]
 LDCM0216  AC100 HCT 116 C315(1.60); C334(0.78); C702(0.14); C711(0.14)  LDD0533  [11]
 LDCM0217  AC101 HCT 116 C315(1.42); C334(0.84); C702(0.29); C711(0.29)  LDD0534  [11]
 LDCM0218  AC102 HCT 116 C315(1.29); C334(0.96); C702(0.65); C711(0.65)  LDD0535  [11]
 LDCM0219  AC103 HCT 116 C315(1.54); C334(0.77); C702(0.31); C711(0.31)  LDD0536  [11]
 LDCM0220  AC104 HCT 116 C315(1.15); C334(0.89); C702(0.58); C711(0.58)  LDD0537  [11]
 LDCM0221  AC105 HCT 116 C315(1.40); C334(0.80); C702(0.27); C711(0.27)  LDD0538  [11]
 LDCM0222  AC106 HCT 116 C315(1.66); C334(0.75); C702(0.18); C711(0.18)  LDD0539  [11]
 LDCM0223  AC107 HCT 116 C315(1.59); C334(0.80); C702(0.21); C711(0.21)  LDD0540  [11]
 LDCM0224  AC108 HCT 116 C315(1.66); C334(0.94); C702(0.14); C711(0.14)  LDD0541  [11]
 LDCM0225  AC109 HCT 116 C315(0.96); C334(0.83); C702(0.47); C711(0.47)  LDD0542  [11]
 LDCM0226  AC11 HCT 116 C315(1.32); C334(0.85); C721(0.74); C799(0.95)  LDD0543  [11]
 LDCM0227  AC110 HCT 116 C315(1.56); C334(0.78); C702(0.22); C711(0.22)  LDD0544  [11]
 LDCM0228  AC111 HCT 116 C315(1.66); C334(0.71); C702(0.16); C711(0.16)  LDD0545  [11]
 LDCM0229  AC112 HCT 116 C315(1.39); C334(0.68); C702(0.23); C711(0.23)  LDD0546  [11]
 LDCM0230  AC113 HCT 116 C315(1.05); C334(1.27); C702(1.15); C711(1.15)  LDD0547  [11]
 LDCM0231  AC114 HCT 116 C315(0.91); C334(1.10); C702(1.16); C711(1.03)  LDD0548  [11]
 LDCM0232  AC115 HCT 116 C315(0.88); C334(1.09); C702(0.85); C711(0.84)  LDD0549  [11]
 LDCM0233  AC116 HCT 116 C315(2.54); C334(1.13); C702(0.86); C711(0.90)  LDD0550  [11]
 LDCM0234  AC117 HCT 116 C315(0.94); C334(0.99); C702(0.82); C711(0.93)  LDD0551  [11]
 LDCM0235  AC118 HCT 116 C315(0.93); C334(1.13); C702(1.02); C711(1.06)  LDD0552  [11]
 LDCM0236  AC119 HCT 116 C315(0.99); C334(1.04); C702(0.79); C711(0.84)  LDD0553  [11]
 LDCM0237  AC12 HCT 116 C315(1.14); C334(0.91); C721(1.05); C799(1.10)  LDD0554  [11]
 LDCM0238  AC120 HCT 116 C315(0.94); C334(1.20); C702(1.39); C711(1.09)  LDD0555  [11]
 LDCM0239  AC121 HCT 116 C315(0.88); C334(1.14); C702(0.70); C711(0.83)  LDD0556  [11]
 LDCM0240  AC122 HCT 116 C315(1.03); C334(1.11); C702(0.98); C711(1.05)  LDD0557  [11]
 LDCM0241  AC123 HCT 116 C315(0.91); C334(1.04); C702(0.92); C711(0.89)  LDD0558  [11]
 LDCM0242  AC124 HCT 116 C315(0.97); C334(1.10); C702(0.85); C711(0.98)  LDD0559  [11]
 LDCM0243  AC125 HCT 116 C315(1.11); C334(1.28); C702(1.02); C711(1.07)  LDD0560  [11]
 LDCM0244  AC126 HCT 116 C315(1.00); C334(1.21); C702(0.73); C711(0.82)  LDD0561  [11]
 LDCM0245  AC127 HCT 116 C315(0.99); C334(1.12); C702(0.91); C711(0.83)  LDD0562  [11]
 LDCM0246  AC128 HCT 116 C315(0.97); C702(1.25); C711(1.25); C721(1.03)  LDD0563  [11]
 LDCM0247  AC129 HCT 116 C315(1.09); C702(1.82); C711(1.82); C721(1.73)  LDD0564  [11]
 LDCM0249  AC130 HCT 116 C315(1.16); C702(0.80); C711(0.80); C721(1.19)  LDD0566  [11]
 LDCM0250  AC131 HCT 116 C315(1.15); C702(2.24); C711(2.24); C721(1.47)  LDD0567  [11]
 LDCM0251  AC132 HCT 116 C315(1.42); C702(0.59); C711(0.59); C721(1.52)  LDD0568  [11]
 LDCM0252  AC133 HCT 116 C315(1.19); C702(0.92); C711(0.92); C721(1.17)  LDD0569  [11]
 LDCM0253  AC134 HCT 116 C315(1.42); C702(0.79); C711(0.79); C721(0.84)  LDD0570  [11]
 LDCM0254  AC135 HCT 116 C315(1.20); C702(0.62); C711(0.62); C721(0.91)  LDD0571  [11]
 LDCM0255  AC136 HCT 116 C315(1.34); C702(0.78); C711(0.78); C721(0.92)  LDD0572  [11]
 LDCM0256  AC137 HCT 116 C315(1.34); C702(0.87); C711(0.87); C721(1.07)  LDD0573  [11]
 LDCM0257  AC138 HCT 116 C315(1.83); C702(0.69); C711(0.69); C721(0.84)  LDD0574  [11]
 LDCM0258  AC139 HCT 116 C315(1.65); C702(0.51); C711(0.51); C721(0.95)  LDD0575  [11]
 LDCM0259  AC14 HCT 116 C315(1.08); C334(0.98); C721(0.95); C799(1.10)  LDD0576  [11]
 LDCM0260  AC140 HCT 116 C315(2.01); C702(0.52); C711(0.52); C721(0.84)  LDD0577  [11]
 LDCM0261  AC141 HCT 116 C315(1.81); C702(0.70); C711(0.70); C721(0.91)  LDD0578  [11]
 LDCM0262  AC142 HCT 116 C315(1.48); C702(1.13); C711(1.13); C721(1.82)  LDD0579  [11]
 LDCM0263  AC143 HCT 116 C90(0.69); C721(0.84); C702(0.87); C711(0.87)  LDD0580  [11]
 LDCM0264  AC144 HCT 116 C702(0.44); C711(0.44); C799(0.52); C721(0.60)  LDD0581  [11]
 LDCM0265  AC145 HCT 116 C702(0.74); C711(0.74); C799(0.84); C721(1.00)  LDD0582  [11]
 LDCM0266  AC146 HCT 116 C702(0.51); C711(0.51); C721(0.63); C799(0.64)  LDD0583  [11]
 LDCM0267  AC147 HCT 116 C702(0.35); C711(0.35); C799(0.50); C721(0.65)  LDD0584  [11]
 LDCM0268  AC148 HCT 116 C702(0.41); C711(0.41); C721(0.45); C799(0.50)  LDD0585  [11]
 LDCM0269  AC149 HCT 116 C702(0.37); C711(0.37); C799(0.48); C721(0.54)  LDD0586  [11]
 LDCM0270  AC15 HCT 116 C721(0.85); C896(0.97); C799(0.97); C961(0.98)  LDD0587  [11]
 LDCM0271  AC150 HCT 116 C799(0.73); C721(0.86); C702(0.87); C711(0.87)  LDD0588  [11]
 LDCM0272  AC151 HCT 116 C799(0.75); C721(0.80); C702(0.96); C711(0.96)  LDD0589  [11]
 LDCM0273  AC152 HCT 116 C799(0.46); C721(0.47); C702(0.48); C711(0.48)  LDD0590  [11]
 LDCM0274  AC153 HCT 116 C702(0.37); C711(0.37); C721(0.44); C799(0.54)  LDD0591  [11]
 LDCM0621  AC154 HCT 116 C315(1.20); C702(0.52); C711(0.52); C721(0.57)  LDD2158  [11]
 LDCM0622  AC155 HCT 116 C315(1.35); C702(0.46); C711(0.46); C721(0.49)  LDD2159  [11]
 LDCM0623  AC156 HCT 116 C315(1.13); C702(0.91); C711(0.91); C721(0.92)  LDD2160  [11]
 LDCM0624  AC157 HCT 116 C315(0.99); C702(1.03); C711(1.03); C721(0.95)  LDD2161  [11]
 LDCM0276  AC17 HCT 116 C799(0.89); C721(0.96); C961(0.99); C90(1.02)  LDD0593  [11]
 LDCM0277  AC18 HCT 116 C721(0.70); C896(0.71); C702(0.73); C711(0.73)  LDD0594  [11]
 LDCM0278  AC19 HCT 116 C896(0.80); C721(0.84); C799(0.87); C702(0.97)  LDD0595  [11]
 LDCM0279  AC2 HCT 116 C961(0.93); C799(0.97); C721(1.08); C315(1.12)  LDD0596  [11]
 LDCM0280  AC20 HCT 116 C702(0.81); C711(0.81); C896(0.82); C721(0.84)  LDD0597  [11]
 LDCM0281  AC21 HCT 116 C896(0.78); C702(0.81); C711(0.81); C961(0.87)  LDD0598  [11]
 LDCM0282  AC22 HCT 116 C896(0.79); C961(0.86); C799(0.93); C721(0.95)  LDD0599  [11]
 LDCM0283  AC23 HCT 116 C702(0.80); C711(0.80); C799(0.88); C961(0.94)  LDD0600  [11]
 LDCM0284  AC24 HCT 116 C961(0.92); C90(0.94); C799(0.94); C702(1.00)  LDD0601  [11]
 LDCM0285  AC25 HCT 116 C702(0.79); C711(0.79); C799(0.95); C334(0.96)  LDD0602  [11]
 LDCM0286  AC26 HCT 116 C702(0.25); C711(0.25); C799(0.74); C334(0.83)  LDD0603  [11]
 LDCM0287  AC27 HCT 116 C702(0.35); C711(0.35); C799(0.70); C334(0.73)  LDD0604  [11]
 LDCM0288  AC28 HCT 116 C702(0.28); C711(0.28); C799(0.71); C334(0.75)  LDD0605  [11]
 LDCM0289  AC29 HCT 116 C702(0.22); C711(0.22); C334(0.63); C799(0.69)  LDD0606  [11]
 LDCM0290  AC3 HCT 116 C223(0.81); C896(0.91); C799(0.97); C961(1.06)  LDD0607  [11]
 LDCM0291  AC30 HCT 116 C702(0.19); C711(0.19); C799(0.62); C334(0.62)  LDD0608  [11]
 LDCM0292  AC31 HCT 116 C702(0.28); C711(0.28); C334(0.67); C799(0.77)  LDD0609  [11]
 LDCM0293  AC32 HCT 116 C702(0.13); C711(0.13); C799(0.50); C334(0.55)  LDD0610  [11]
 LDCM0294  AC33 HCT 116 C799(0.56); C896(0.73); C702(0.74); C711(0.74)  LDD0611  [11]
 LDCM0295  AC34 HCT 116 C799(0.49); C721(0.88); C334(0.91); C90(0.97)  LDD0612  [11]
 LDCM0296  AC35 HCT 116 C315(0.87); C961(1.01); C90(1.11); C334(1.12)  LDD0613  [11]
 LDCM0297  AC36 HCT 116 C315(0.92); C334(0.96); C896(0.97); C961(0.99)  LDD0614  [11]
 LDCM0298  AC37 HCT 116 C702(0.77); C711(0.77); C315(0.90); C961(1.00)  LDD0615  [11]
 LDCM0299  AC38 HCT 116 C896(0.78); C702(0.92); C711(0.92); C334(0.94)  LDD0616  [11]
 LDCM0300  AC39 HCT 116 C702(0.58); C711(0.58); C334(0.97); C896(0.98)  LDD0617  [11]
 LDCM0301  AC4 HCT 116 C799(0.71); C223(0.94); C896(1.03); C721(1.07)  LDD0618  [11]
 LDCM0302  AC40 HCT 116 C702(0.53); C711(0.53); C721(0.76); C896(0.84)  LDD0619  [11]
 LDCM0303  AC41 HCT 116 C896(0.80); C961(0.88); C334(0.95); C721(0.97)  LDD0620  [11]
 LDCM0304  AC42 HCT 116 C702(0.65); C711(0.65); C896(0.76); C334(0.86)  LDD0621  [11]
 LDCM0305  AC43 HCT 116 C702(0.81); C711(0.81); C334(0.84); C896(0.96)  LDD0622  [11]
 LDCM0306  AC44 HCT 116 C702(0.75); C711(0.75); C721(0.93); C961(0.94)  LDD0623  [11]
 LDCM0307  AC45 HCT 116 C702(0.59); C711(0.59); C721(0.88); C799(0.96)  LDD0624  [11]
 LDCM0308  AC46 HCT 116 C702(0.70); C711(0.70); C896(0.77); C721(0.95)  LDD0625  [11]
 LDCM0309  AC47 HCT 116 C702(0.62); C711(0.62); C896(0.76); C334(0.98)  LDD0626  [11]
 LDCM0310  AC48 HCT 116 C702(0.56); C711(0.56); C896(0.81); C334(0.92)  LDD0627  [11]
 LDCM0311  AC49 HCT 116 C702(0.53); C711(0.53); C721(0.65); C896(0.76)  LDD0628  [11]
 LDCM0312  AC5 HCT 116 C799(0.76); C721(0.97); C223(0.98); C315(1.12)  LDD0629  [11]
 LDCM0313  AC50 HCT 116 C702(0.44); C711(0.44); C896(0.69); C721(0.74)  LDD0630  [11]
 LDCM0314  AC51 HCT 116 C896(0.64); C90(0.87); C334(0.93); C702(0.98)  LDD0631  [11]
 LDCM0315  AC52 HCT 116 C702(0.59); C711(0.59); C896(0.71); C721(0.93)  LDD0632  [11]
 LDCM0316  AC53 HCT 116 C702(0.65); C711(0.65); C896(0.86); C799(0.91)  LDD0633  [11]
 LDCM0317  AC54 HCT 116 C721(0.72); C702(0.78); C711(0.78); C334(0.90)  LDD0634  [11]
 LDCM0318  AC55 HCT 116 C702(0.63); C711(0.63); C90(0.63); C334(0.79)  LDD0635  [11]
 LDCM0319  AC56 HCT 116 C702(0.57); C711(0.57); C896(0.66); C334(0.72)  LDD0636  [11]
 LDCM0320  AC57 HCT 116 C721(0.54); C702(0.81); C711(0.81); C799(0.83)  LDD0637  [11]
 LDCM0321  AC58 HCT 116 C721(0.61); C896(0.69); C702(0.85); C711(0.85)  LDD0638  [11]
 LDCM0322  AC59 HCT 116 C721(0.46); C799(0.80); C702(0.83); C711(0.83)  LDD0639  [11]
 LDCM0323  AC6 HCT 116 C721(0.62); C334(0.73); C799(0.76); C90(0.95)  LDD0640  [11]
 LDCM0324  AC60 HCT 116 C721(0.66); C799(0.71); C896(0.86); C702(1.08)  LDD0641  [11]
 LDCM0325  AC61 HCT 116 C799(0.82); C721(0.82); C896(0.83); C702(0.89)  LDD0642  [11]
 LDCM0326  AC62 HCT 116 C721(0.47); C702(0.58); C711(0.58); C799(0.74)  LDD0643  [11]
 LDCM0327  AC63 HCT 116 C721(0.62); C702(0.69); C711(0.69); C799(0.71)  LDD0644  [11]
 LDCM0328  AC64 HCT 116 C721(0.50); C799(0.73); C702(0.81); C711(0.81)  LDD0645  [11]
 LDCM0329  AC65 HCT 116 C702(0.52); C711(0.52); C721(0.70); C799(0.76)  LDD0646  [11]
 LDCM0330  AC66 HCT 116 C702(0.72); C711(0.72); C721(0.77); C896(0.78)  LDD0647  [11]
 LDCM0331  AC67 HCT 116 C702(0.57); C711(0.57); C721(0.57); C90(0.61)  LDD0648  [11]
 LDCM0332  AC68 HCT 116 C721(0.68); C90(0.70); C896(0.86); C799(0.88)  LDD0649  [11]
 LDCM0333  AC69 HCT 116 C721(0.61); C90(0.81); C799(0.92); C223(1.01)  LDD0650  [11]
 LDCM0334  AC7 HCT 116 C721(0.83); C334(0.95); C896(0.98); C799(0.98)  LDD0651  [11]
 LDCM0335  AC70 HCT 116 C90(0.61); C721(0.65); C702(0.75); C711(0.75)  LDD0652  [11]
 LDCM0336  AC71 HCT 116 C223(0.72); C90(0.85); C721(0.95); C799(0.98)  LDD0653  [11]
 LDCM0337  AC72 HCT 116 C721(0.62); C90(0.63); C223(0.72); C702(0.81)  LDD0654  [11]
 LDCM0338  AC73 HCT 116 C90(0.59); C721(0.65); C334(0.68); C702(0.73)  LDD0655  [11]
 LDCM0339  AC74 HCT 116 C721(0.65); C334(0.74); C223(0.87); C896(0.95)  LDD0656  [11]
 LDCM0340  AC75 HCT 116 C90(0.56); C702(0.64); C711(0.64); C721(0.74)  LDD0657  [11]
 LDCM0341  AC76 HCT 116 C721(0.64); C223(0.80); C334(0.87); C896(0.99)  LDD0658  [11]
 LDCM0342  AC77 HCT 116 C90(0.60); C721(0.65); C223(0.68); C896(0.79)  LDD0659  [11]
 LDCM0343  AC78 HCT 116 C90(0.56); C799(0.89); C223(0.95); C702(0.97)  LDD0660  [11]
 LDCM0344  AC79 HCT 116 C90(0.58); C721(0.82); C702(0.84); C711(0.84)  LDD0661  [11]
 LDCM0345  AC8 HCT 116 C721(0.66); C799(0.82); C334(0.85); C90(0.93)  LDD0662  [11]
 LDCM0346  AC80 HCT 116 C721(0.56); C334(0.93); C223(0.94); C896(0.97)  LDD0663  [11]
 LDCM0347  AC81 HCT 116 C90(0.72); C721(0.75); C799(0.85); C223(1.10)  LDD0664  [11]
 LDCM0348  AC82 HCT 116 C90(0.68); C721(0.82); C334(0.84); C799(0.96)  LDD0665  [11]
 LDCM0349  AC83 HCT 116 C702(0.34); C711(0.34); C799(0.58); C896(0.71)  LDD0666  [11]
 LDCM0350  AC84 HCT 116 C702(0.41); C711(0.41); C799(0.59); C721(0.59)  LDD0667  [11]
 LDCM0351  AC85 HCT 116 C702(0.52); C711(0.52); C799(0.76); C896(0.78)  LDD0668  [11]
 LDCM0352  AC86 HCT 116 C702(0.48); C711(0.48); C799(0.64); C721(0.66)  LDD0669  [11]
 LDCM0353  AC87 HCT 116 C90(0.71); C721(0.71); C702(0.77); C711(0.77)  LDD0670  [11]
 LDCM0354  AC88 HCT 116 C721(0.60); C90(0.65); C799(0.66); C896(0.68)  LDD0671  [11]
 LDCM0355  AC89 HCT 116 C702(0.39); C711(0.39); C799(0.56); C896(0.65)  LDD0672  [11]
 LDCM0357  AC90 HCT 116 C90(0.68); C702(0.97); C711(0.97); C896(1.03)  LDD0674  [11]
 LDCM0358  AC91 HCT 116 C702(0.29); C711(0.29); C721(0.72); C799(0.73)  LDD0675  [11]
 LDCM0359  AC92 HCT 116 C702(0.27); C711(0.27); C799(0.65); C721(0.72)  LDD0676  [11]
 LDCM0360  AC93 HCT 116 C702(0.60); C711(0.60); C799(0.70); C721(0.73)  LDD0677  [11]
 LDCM0361  AC94 HCT 116 C702(0.74); C711(0.74); C223(0.77); C721(0.95)  LDD0678  [11]
 LDCM0362  AC95 HCT 116 C90(0.65); C799(0.76); C896(0.84); C721(0.94)  LDD0679  [11]
 LDCM0363  AC96 HCT 116 C702(0.41); C711(0.41); C896(0.95); C799(0.96)  LDD0680  [11]
 LDCM0364  AC97 HCT 116 C702(0.36); C711(0.36); C799(0.50); C721(0.55)  LDD0681  [11]
 LDCM0365  AC98 HCT 116 C702(0.17); C711(0.17); C896(0.31); C721(0.38)  LDD0682  [11]
 LDCM0366  AC99 HCT 116 C702(0.26); C711(0.26); C799(0.60); C721(0.63)  LDD0683  [11]
 LDCM0248  AKOS034007472 HCT 116 C315(1.03); C334(0.93); C721(1.18); C799(1.13)  LDD0565  [11]
 LDCM0356  AKOS034007680 HCT 116 C721(0.91); C799(0.97); C961(0.98); C334(1.00)  LDD0673  [11]
 LDCM0275  AKOS034007705 HCT 116 C721(0.55); C896(0.65); C799(0.68); C334(0.76)  LDD0592  [11]
 LDCM0020  ARS-1620 HCC44 C334(0.95); C896(1.00)  LDD2171  [11]
 LDCM0498  BS-3668 MDA-MB-231 C315(0.45)  LDD2091  [6]
 LDCM0108  Chloroacetamide HeLa C961(0.00); C721(0.00); C90(0.00); H1012(0.00)  LDD0222  [25]
 LDCM0632  CL-Sc Hep-G2 C315(2.38); C315(0.89); C510(0.51); C223(0.20)  LDD2227  [18]
 LDCM0367  CL1 HCT 116 C799(0.95); C315(0.97); C90(1.02); C896(1.13)  LDD0684  [11]
 LDCM0368  CL10 HCT 116 C90(0.85); C721(0.91); C799(1.07); C334(1.10)  LDD0685  [11]
 LDCM0369  CL100 HCT 116 C799(0.77); C896(0.86); C721(0.87); C334(1.11)  LDD0686  [11]
 LDCM0370  CL101 HCT 116 C721(0.71); C799(0.83); C334(0.85); C896(0.90)  LDD0687  [11]
 LDCM0371  CL102 HCT 116 C334(0.75); C961(0.85); C90(0.93); C721(1.01)  LDD0688  [11]
 LDCM0372  CL103 HCT 116 C334(0.88); C961(0.92); C721(1.09); C896(1.09)  LDD0689  [11]
 LDCM0373  CL104 HCT 116 C90(0.98); C961(1.00); C799(1.03); C721(1.04)  LDD0690  [11]
 LDCM0374  CL105 HCT 116 C896(0.72); C721(0.86); C799(0.87); C702(1.02)  LDD0691  [11]
 LDCM0375  CL106 HCT 116 C702(0.48); C711(0.48); C896(0.70); C799(0.81)  LDD0692  [11]
 LDCM0376  CL107 HCT 116 C702(0.44); C711(0.44); C721(0.78); C799(0.79)  LDD0693  [11]
 LDCM0377  CL108 HCT 116 C702(0.43); C711(0.43); C721(0.63); C799(0.74)  LDD0694  [11]
 LDCM0378  CL109 HCT 116 C721(0.69); C702(0.71); C711(0.71); C799(0.79)  LDD0695  [11]
 LDCM0379  CL11 HCT 116 C721(0.80); C90(0.85); C334(0.86); C799(1.17)  LDD0696  [11]
 LDCM0380  CL110 HCT 116 C721(0.55); C702(0.60); C711(0.60); C799(0.67)  LDD0697  [11]
 LDCM0381  CL111 HCT 116 C721(0.67); C799(0.73); C896(0.73); C702(0.78)  LDD0698  [11]
 LDCM0382  CL112 HCT 116 C702(0.66); C711(0.66); C334(0.77); C799(0.92)  LDD0699  [11]
 LDCM0383  CL113 HCT 116 C702(0.34); C711(0.34); C799(0.52); C334(0.64)  LDD0700  [11]
 LDCM0384  CL114 HCT 116 C334(0.54); C702(0.67); C711(0.67); C799(0.73)  LDD0701  [11]
 LDCM0385  CL115 HCT 116 C799(0.66); C334(0.67); C702(0.69); C711(0.69)  LDD0702  [11]
 LDCM0386  CL116 HCT 116 C799(0.71); C334(0.85); C896(0.94); C721(0.97)  LDD0703  [11]
 LDCM0387  CL117 HCT 116 C896(0.66); C702(0.67); C711(0.67); C721(0.80)  LDD0704  [11]
 LDCM0388  CL118 HCT 116 C702(0.79); C711(0.79); C799(0.97); C721(0.98)  LDD0705  [11]
 LDCM0389  CL119 HCT 116 C702(0.69); C711(0.69); C721(0.87); C799(0.90)  LDD0706  [11]
 LDCM0390  CL12 HCT 116 C334(0.67); C90(0.82); C721(0.91); C799(1.17)  LDD0707  [11]
 LDCM0391  CL120 HCT 116 C702(0.65); C711(0.65); C334(0.85); C896(0.85)  LDD0708  [11]
 LDCM0392  CL121 HCT 116 C721(0.65); C896(0.68); C90(0.79); C334(0.84)  LDD0709  [11]
 LDCM0393  CL122 HCT 116 C896(0.69); C721(0.90); C702(0.93); C711(0.93)  LDD0710  [11]
 LDCM0394  CL123 HCT 116 C702(0.66); C711(0.66); C721(0.75); C896(0.81)  LDD0711  [11]
 LDCM0395  CL124 HCT 116 C702(0.58); C711(0.58); C896(0.72); C721(0.74)  LDD0712  [11]
 LDCM0396  CL125 HCT 116 C799(0.80); C334(1.01); C896(1.10); C90(1.11)  LDD0713  [11]
 LDCM0397  CL126 HCT 116 C721(0.83); C799(0.87); C702(0.92); C711(0.92)  LDD0714  [11]
 LDCM0398  CL127 HCT 116 C799(0.81); C721(0.85); C702(0.91); C711(0.91)  LDD0715  [11]
 LDCM0399  CL128 HCT 116 C721(0.51); C702(0.62); C711(0.62); C90(0.82)  LDD0716  [11]
 LDCM0400  CL13 HCT 116 C334(0.91); C90(1.01); C721(1.06); C315(1.11)  LDD0717  [11]
 LDCM0401  CL14 HCT 116 C315(0.91); C896(0.96); C90(1.00); C721(1.09)  LDD0718  [11]
 LDCM0402  CL15 HCT 116 C721(0.62); C90(0.98); C315(1.09); C334(1.15)  LDD0719  [11]
 LDCM0403  CL16 HCT 116 C721(0.65); C90(0.73); C896(0.77); C799(0.81)  LDD0720  [11]
 LDCM0404  CL17 HCT 116 C896(0.71); C90(0.75); C799(0.95); C721(0.97)  LDD0721  [11]
 LDCM0405  CL18 HCT 116 C896(0.75); C90(0.76); C721(0.89); C799(0.92)  LDD0722  [11]
 LDCM0406  CL19 HCT 116 C896(0.71); C90(0.73); C721(0.76); C315(0.97)  LDD0723  [11]
 LDCM0407  CL2 HCT 116 C896(0.86); C315(0.97); C90(1.03); C799(1.06)  LDD0724  [11]
 LDCM0408  CL20 HCT 116 C721(0.64); C90(0.76); C896(0.82); C799(0.88)  LDD0725  [11]
 LDCM0409  CL21 HCT 116 C896(0.58); C721(0.68); C90(0.97); C799(1.02)  LDD0726  [11]
 LDCM0410  CL22 HCT 116 C896(0.60); C721(0.65); C90(0.84); C799(1.19)  LDD0727  [11]
 LDCM0411  CL23 HCT 116 C721(0.59); C896(0.67); C799(0.76); C315(1.01)  LDD0728  [11]
 LDCM0412  CL24 HCT 116 C315(1.38); C721(0.55); C799(0.74); C896(0.62)  LDD0729  [11]
 LDCM0413  CL25 HCT 116 C315(1.29); C721(0.49); C799(0.76); C896(0.71)  LDD0730  [11]
 LDCM0414  CL26 HCT 116 C315(1.15); C721(0.48); C799(0.69); C896(0.72)  LDD0731  [11]
 LDCM0415  CL27 HCT 116 C315(1.04); C721(0.79); C799(1.01); C896(0.99)  LDD0732  [11]
 LDCM0416  CL28 HCT 116 C315(1.13); C721(0.56); C799(0.84); C896(0.73)  LDD0733  [11]
 LDCM0417  CL29 HCT 116 C315(1.10); C721(0.78); C799(1.06); C896(0.70)  LDD0734  [11]
 LDCM0418  CL3 HCT 116 C315(0.95); C334(1.26); C721(1.08); C799(1.08)  LDD0735  [11]
 LDCM0419  CL30 HCT 116 C315(1.02); C721(0.78); C799(1.01); C896(0.84)  LDD0736  [11]
 LDCM0420  CL31 HCT 116 C315(1.05); C334(1.19); C702(0.94); C711(0.94)  LDD0737  [11]
 LDCM0421  CL32 HCT 116 C315(1.14); C334(0.93); C702(1.26); C711(1.26)  LDD0738  [11]
 LDCM0422  CL33 HCT 116 C315(1.15); C334(0.88); C702(0.96); C711(0.96)  LDD0739  [11]
 LDCM0423  CL34 HCT 116 C315(1.33); C334(1.08); C702(0.62); C711(0.62)  LDD0740  [11]
 LDCM0424  CL35 HCT 116 C315(1.26); C334(1.03); C702(0.50); C711(0.50)  LDD0741  [11]
 LDCM0425  CL36 HCT 116 C315(1.17); C334(1.06); C702(0.56); C711(0.56)  LDD0742  [11]
 LDCM0426  CL37 HCT 116 C315(1.37); C334(1.03); C702(0.45); C711(0.45)  LDD0743  [11]
 LDCM0428  CL39 HCT 116 C315(1.33); C334(0.89); C702(0.66); C711(0.66)  LDD0745  [11]
 LDCM0429  CL4 HCT 116 C315(0.94); C334(1.12); C721(0.95); C799(1.04)  LDD0746  [11]
 LDCM0430  CL40 HCT 116 C315(1.22); C334(1.00); C702(0.57); C711(0.57)  LDD0747  [11]
 LDCM0431  CL41 HCT 116 C315(1.22); C334(1.01); C702(0.67); C711(0.67)  LDD0748  [11]
 LDCM0432  CL42 HCT 116 C315(1.80); C334(0.99); C702(0.63); C711(0.63)  LDD0749  [11]
 LDCM0433  CL43 HCT 116 C315(1.37); C334(1.04); C702(0.72); C711(0.72)  LDD0750  [11]
 LDCM0434  CL44 HCT 116 C315(1.25); C334(1.08); C702(0.77); C711(0.77)  LDD0751  [11]
 LDCM0435  CL45 HCT 116 C315(1.42); C334(1.13); C702(0.46); C711(0.46)  LDD0752  [11]
 LDCM0436  CL46 HCT 116 C315(1.16); C334(0.95); C721(2.10); C799(0.87)  LDD0753  [11]
 LDCM0437  CL47 HCT 116 C315(1.00); C334(0.89); C721(1.89); C799(0.97)  LDD0754  [11]
 LDCM0438  CL48 HCT 116 C315(1.16); C334(0.82); C721(1.63); C799(0.94)  LDD0755  [11]
 LDCM0439  CL49 HCT 116 C315(1.03); C334(0.86); C721(1.12); C799(1.11)  LDD0756  [11]
 LDCM0440  CL5 HCT 116 C315(0.93); C334(1.07); C721(1.11); C799(1.25)  LDD0757  [11]
 LDCM0441  CL50 HCT 116 C315(1.03); C334(0.90); C721(1.72); C799(1.02)  LDD0758  [11]
 LDCM0442  CL51 HCT 116 C315(1.07); C334(0.98); C721(1.45); C799(1.07)  LDD0759  [11]
 LDCM0443  CL52 HCT 116 C315(1.16); C334(0.82); C721(1.89); C799(0.80)  LDD0760  [11]
 LDCM0444  CL53 HCT 116 C315(0.96); C334(0.77); C721(1.54); C799(0.77)  LDD0761  [11]
 LDCM0445  CL54 HCT 116 C315(1.00); C334(0.83); C721(1.61); C799(0.97)  LDD0762  [11]
 LDCM0446  CL55 HCT 116 C315(0.98); C334(1.01); C721(1.50); C799(1.01)  LDD0763  [11]
 LDCM0447  CL56 HCT 116 C315(0.90); C334(0.97); C721(1.26); C799(0.96)  LDD0764  [11]
 LDCM0448  CL57 HCT 116 C315(0.88); C334(0.91); C721(1.69); C799(0.99)  LDD0765  [11]
 LDCM0449  CL58 HCT 116 C315(1.00); C334(0.85); C721(1.88); C799(0.98)  LDD0766  [11]
 LDCM0450  CL59 HCT 116 C315(0.88); C334(0.97); C721(1.25); C799(1.05)  LDD0767  [11]
 LDCM0451  CL6 HCT 116 C315(1.09); C334(1.16); C721(1.09); C799(1.14)  LDD0768  [11]
 LDCM0452  CL60 HCT 116 C315(0.98); C334(0.95); C721(1.22); C799(0.98)  LDD0769  [11]
 LDCM0453  CL61 HCT 116 C315(1.02); C334(1.30); C721(0.84); C799(0.78)  LDD0770  [11]
 LDCM0454  CL62 HCT 116 C315(1.04); C334(1.12); C721(0.83); C799(0.91)  LDD0771  [11]
 LDCM0455  CL63 HCT 116 C315(1.09); C334(1.06); C721(0.60); C799(0.88)  LDD0772  [11]
 LDCM0456  CL64 HCT 116 C315(1.01); C334(1.25); C721(0.39); C799(0.91)  LDD0773  [11]
 LDCM0457  CL65 HCT 116 C315(0.90); C334(1.01); C721(0.73); C799(0.84)  LDD0774  [11]
 LDCM0458  CL66 HCT 116 C315(0.94); C334(1.13); C721(0.30); C799(0.96)  LDD0775  [11]
 LDCM0459  CL67 HCT 116 C315(0.87); C334(1.04); C721(0.37); C799(0.97)  LDD0776  [11]
 LDCM0460  CL68 HCT 116 C315(0.87); C334(1.38); C721(0.52); C799(0.74)  LDD0777  [11]
 LDCM0461  CL69 HCT 116 C315(0.98); C334(0.86); C721(1.02); C799(0.64)  LDD0778  [11]
 LDCM0462  CL7 HCT 116 C315(1.19); C334(0.87); C721(0.98); C799(1.32)  LDD0779  [11]
 LDCM0463  CL70 HCT 116 C315(0.96); C334(1.04); C721(0.61); C799(0.79)  LDD0780  [11]
 LDCM0464  CL71 HCT 116 C315(1.02); C334(1.12); C721(0.47); C799(0.71)  LDD0781  [11]
 LDCM0465  CL72 HCT 116 C315(1.01); C334(1.17); C721(0.83); C799(0.59)  LDD0782  [11]
 LDCM0466  CL73 HCT 116 C315(0.94); C334(1.24); C721(0.52); C799(0.82)  LDD0783  [11]
 LDCM0467  CL74 HCT 116 C315(0.98); C334(1.00); C721(0.45); C799(0.84)  LDD0784  [11]
 LDCM0469  CL76 HCT 116 C223(1.19); C315(1.09); C334(1.31); C702(2.06)  LDD0786  [11]
 LDCM0470  CL77 HCT 116 C223(2.72); C315(1.23); C334(1.32); C702(1.46)  LDD0787  [11]
 LDCM0471  CL78 HCT 116 C223(1.06); C315(1.51); C334(1.09); C702(1.19)  LDD0788  [11]
 LDCM0472  CL79 HCT 116 C223(2.38); C315(1.23); C334(0.98); C702(2.88)  LDD0789  [11]
 LDCM0473  CL8 HCT 116 C315(1.42); C334(0.62); C721(0.86); C799(0.96)  LDD0790  [11]
 LDCM0474  CL80 HCT 116 C223(3.14); C315(0.99); C334(1.59); C702(1.21)  LDD0791  [11]
 LDCM0475  CL81 HCT 116 C223(1.42); C315(1.20); C334(1.04); C702(2.62)  LDD0792  [11]
 LDCM0476  CL82 HCT 116 C223(1.58); C315(1.51); C334(0.68); C702(2.13)  LDD0793  [11]
 LDCM0477  CL83 HCT 116 C223(1.86); C315(1.36); C334(0.85); C702(2.27)  LDD0794  [11]
 LDCM0478  CL84 HCT 116 C223(2.80); C315(1.83); C334(0.58); C702(2.00)  LDD0795  [11]
 LDCM0479  CL85 HCT 116 C223(1.34); C315(1.22); C334(1.09); C702(2.15)  LDD0796  [11]
 LDCM0480  CL86 HCT 116 C223(1.20); C315(1.19); C334(0.98); C702(2.30)  LDD0797  [11]
 LDCM0481  CL87 HCT 116 C223(1.12); C315(1.40); C334(1.00); C702(2.69)  LDD0798  [11]
 LDCM0482  CL88 HCT 116 C223(1.89); C315(1.46); C334(1.03); C702(2.25)  LDD0799  [11]
 LDCM0483  CL89 HCT 116 C223(1.48); C315(1.84); C334(0.68); C702(1.83)  LDD0800  [11]
 LDCM0484  CL9 HCT 116 C315(1.12); C334(0.98); C721(0.91); C799(0.92)  LDD0801  [11]
 LDCM0485  CL90 HCT 116 C223(0.99); C315(0.99); C334(1.02); C702(2.53)  LDD0802  [11]
 LDCM0486  CL91 HCT 116 C223(1.04); C315(0.96); C334(1.10); C721(0.84)  LDD0803  [11]
 LDCM0487  CL92 HCT 116 C223(0.75); C315(0.97); C334(1.07); C721(0.93)  LDD0804  [11]
 LDCM0488  CL93 HCT 116 C223(1.10); C315(1.03); C334(1.13); C721(1.12)  LDD0805  [11]
 LDCM0489  CL94 HCT 116 C223(1.60); C315(1.06); C334(1.18); C721(0.90)  LDD0806  [11]
 LDCM0490  CL95 HCT 116 C223(1.54); C315(1.21); C334(1.12); C721(0.78)  LDD0807  [11]
 LDCM0491  CL96 HCT 116 C223(1.43); C315(1.06); C334(1.16); C721(0.93)  LDD0808  [11]
 LDCM0492  CL97 HCT 116 C223(1.03); C315(1.01); C334(1.15); C721(0.84)  LDD0809  [11]
 LDCM0493  CL98 HCT 116 C223(0.96); C315(1.28); C334(1.09); C721(0.78)  LDD0810  [11]
 LDCM0494  CL99 HCT 116 C223(0.83); C315(1.15); C334(1.09); C721(0.87)  LDD0811  [11]
 LDCM0191  Compound 21 HEK-293T 3.93  LDD0508  [28]
 LDCM0190  Compound 34 HEK-293T 3.63  LDD0510  [28]
 LDCM0193  Compound 36 HEK-293T 3.98  LDD0511  [28]
 LDCM0198  Dimethyl Fumarate(DMF) T cell C315(8.24)  LDD0513  [31]
 LDCM0495  E2913 HEK-293T C315(0.96); C925(1.01); C334(1.05); C576(1.05)  LDD1698  [32]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C315(1.49); C896(1.10); C961(1.00)  LDD1702  [6]
 LDCM0625  F8 Ramos C315(1.38); C961(0.74); C90(0.74)  LDD2187  [33]
 LDCM0572  Fragment10 MDA-MB-231 C223(2.51)  LDD1465  [34]
 LDCM0573  Fragment11 MDA-MB-231 C223(1.02)  LDD1467  [34]
 LDCM0574  Fragment12 MDA-MB-231 C223(3.06)  LDD1468  [34]
 LDCM0575  Fragment13 Ramos C223(1.28)  LDD1470  [34]
 LDCM0576  Fragment14 MDA-MB-231 C223(1.05)  LDD1471  [34]
 LDCM0579  Fragment20 Ramos C315(1.33); C961(0.85); C90(0.34)  LDD2194  [33]
 LDCM0580  Fragment21 MDA-MB-231 C223(1.76)  LDD1473  [34]
 LDCM0582  Fragment23 Ramos C315(0.69); C961(2.04); C90(0.93)  LDD2196  [33]
 LDCM0578  Fragment27 MDA-MB-231 C223(1.14)  LDD1474  [34]
 LDCM0586  Fragment28 MDA-MB-231 C223(0.99)  LDD1475  [34]
 LDCM0587  Fragment29 Ramos C223(1.04)  LDD1476  [34]
 LDCM0588  Fragment30 Ramos C315(1.13); C961(0.68); C90(0.80)  LDD2199  [33]
 LDCM0589  Fragment31 Ramos C315(0.87); C961(0.78); C90(0.98)  LDD2200  [33]
 LDCM0590  Fragment32 Ramos C315(1.31); C961(0.50); C90(0.45)  LDD2201  [33]
 LDCM0468  Fragment33 HCT 116 C315(0.95); C334(1.28); C721(0.46); C799(0.89)  LDD0785  [11]
 LDCM0596  Fragment38 MDA-MB-231 C223(0.75)  LDD1480  [34]
 LDCM0566  Fragment4 MDA-MB-231 C223(6.76)  LDD1461  [34]
 LDCM0603  Fragment45 MDA-MB-231 C223(20.00)  LDD1482  [34]
 LDCM0427  Fragment51 HCT 116 C315(1.76); C334(1.06); C702(0.50); C711(0.50)  LDD0744  [11]
 LDCM0610  Fragment52 Ramos C315(0.87); C961(0.57); C90(0.89)  LDD2204  [33]
 LDCM0614  Fragment56 Ramos C315(0.95); C961(0.58); C90(1.04)  LDD2205  [33]
 LDCM0569  Fragment7 Ramos C315(0.98); C961(0.83); C90(0.48)  LDD2186  [33]
 LDCM0570  Fragment8 MDA-MB-231 C223(20.00)  LDD1462  [34]
 LDCM0571  Fragment9 Ramos C223(20.00)  LDD1464  [34]
 LDCM0116  HHS-0101 DM93 Y1091(2.91)  LDD0264  [9]
 LDCM0117  HHS-0201 DM93 Y1091(1.46)  LDD0265  [9]
 LDCM0118  HHS-0301 DM93 Y1091(1.14)  LDD0266  [9]
 LDCM0119  HHS-0401 DM93 Y1091(1.98)  LDD0267  [9]
 LDCM0120  HHS-0701 DM93 Y1091(0.53)  LDD0268  [9]
 LDCM0107  IAA HeLa C90(0.00); H1048(0.00); C799(0.00); H855(0.00)  LDD0221  [25]
 LDCM0022  KB02 HCT 116 C334(1.23); C961(1.49)  LDD0080  [11]
 LDCM0023  KB03 HCT 116 C334(1.22); C961(2.42)  LDD0081  [11]
 LDCM0024  KB05 HCT 116 C334(1.34); C961(1.32)  LDD0082  [11]
 LDCM0169  KB63 Ramos 4.40  LDD0432  [35]
 LDCM0509  N-(4-bromo-3,5-dimethylphenyl)-2-nitroacetamide MDA-MB-231 C315(1.00)  LDD2102  [6]
 LDCM0528  N-(4-bromophenyl)-2-cyano-N-phenylacetamide MDA-MB-231 C315(0.38)  LDD2121  [6]
 LDCM0109  NEM HeLa H1048(0.00); H855(0.00); H1016(0.00); H1012(0.00)  LDD0223  [25]
 LDCM0497  Nucleophilic fragment 11b MDA-MB-231 C315(1.09)  LDD2090  [6]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C315(0.93)  LDD2092  [6]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C315(1.03)  LDD2093  [6]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C478(0.26)  LDD2096  [6]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C315(1.09)  LDD2098  [6]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C315(0.79)  LDD2100  [6]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C315(0.68)  LDD2104  [6]
 LDCM0512  Nucleophilic fragment 19a MDA-MB-231 C315(1.60); C799(0.79)  LDD2105  [6]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C799(0.88)  LDD2107  [6]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C315(0.94)  LDD2108  [6]
 LDCM0521  Nucleophilic fragment 23b MDA-MB-231 C315(0.79)  LDD2114  [6]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C315(0.93)  LDD2123  [6]
 LDCM0531  Nucleophilic fragment 28b MDA-MB-231 C315(1.21)  LDD2124  [6]
 LDCM0533  Nucleophilic fragment 29b MDA-MB-231 C315(0.86)  LDD2126  [6]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C315(0.81); C799(0.92)  LDD2135  [6]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C315(1.16)  LDD2137  [6]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C799(0.54)  LDD2141  [6]
 LDCM0550  Nucleophilic fragment 5a MDA-MB-231 C315(2.30)  LDD2144  [6]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C315(0.73)  LDD2146  [6]
 LDCM0131  RA190 MM1.R C315(1.15)  LDD0304  [36]
 LDCM0021  THZ1 HCT 116 C334(0.95); C896(1.00)  LDD2173  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Histone-lysine N-methyltransferase SETD1A (SETD1A) Class V-like SAM-binding methyltransferase superfamily O15047
Cullin-4B (CUL4B) Cullin family Q13620
Probable maltase-glucoamylase 2 (MGAM2) Glycosyl hydrolase 31 family Q2M2H8
E3 ubiquitin-protein ligase Mdm2 (MDM2) MDM2/MDM4 family Q00987
Nuclear pore complex protein Nup98-Nup96 (NUP98) Nucleoporin GLFG family P52948
Serine/threonine-protein kinase WNK1 (WNK1) Ser/Thr protein kinase family Q9H4A3
Mitogen-activated protein kinase kinase kinase 1 (MAP3K1) STE Ser/Thr protein kinase family Q13233
E1A-binding protein p400 (EP400) SNF2/RAD54 helicase family Q96L91
E3 ubiquitin-protein ligase UBR4 (UBR4) UBR4 family Q5T4S7
E3 ubiquitin-protein ligase TRIP12 (TRIP12) UPL family Q14669
E3 ubiquitin-protein ligase RING1 (RING1) . Q06587
E3 ubiquitin-protein ligase RING2 (RNF2) . Q99496
Polycomb complex protein BMI-1 (BMI1) . P35226
Polycomb group RING finger protein 2 (PCGF2) . P35227
RNA-binding E3 ubiquitin-protein ligase MEX3C (MEX3C) . Q5U5Q3
Transporter and channel
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Myelin and lymphocyte protein (MAL) MAL family P21145
Neurogenic locus notch homolog protein 1 (NOTCH1) NOTCH family P46531
Nuclear pore complex protein Nup153 (NUP153) NUP153 family P49790
Cellular tumor antigen p53 (TP53) P53 family P04637
Nuclear envelope pore membrane protein POM 121 (POM121) POM121 family Q96HA1
Protein SON (SON) . P18583
Transcription factor
Click To Hide/Show 9 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein cut-like 2 (CUX2) CUT homeobox family O14529
Mothers against decapentaplegic homolog 3 (SMAD3) Dwarfin/SMAD family P84022
Zinc finger protein 76 (ZNF76) Krueppel C2H2-type zinc-finger protein family P36508
Estrogen receptor (ESR1) Nuclear hormone receptor family P03372
Transcription factor 7-like 2 (TCF7L2) TCF/LEF family Q9NQB0
Teashirt homolog 1 (TSHZ1) Teashirt C2H2-type zinc-finger protein family Q6ZSZ6
MAX gene-associated protein (MGA) . Q8IWI9
Protein AF-10 (MLLT10) . P55197
Transcription factor SOX-2 (SOX2) . P48431
Other
Click To Hide/Show 27 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
BCL-6 corepressor (BCOR) BCOR family Q6W2J9
Death domain-associated protein 6 (DAXX) DAXX family Q9UER7
Protein FAM193A (FAM193A) FAM193 family P78312
Pre-mRNA-splicing regulator WTAP (WTAP) Fl(2)d family Q15007
Inhibitor of growth protein 3 (ING3) ING family Q9NXR8
Prelamin-A/C (LMNA) Intermediate filament family P02545
Protein Mdm4 (MDM4) MDM2/MDM4 family O15151
Testis-specific Y-encoded-like protein 5 (TSPYL5) Nucleosome assembly protein (NAP) family Q86VY4
Retinoblastoma-associated protein (RB1) Retinoblastoma protein (RB) family P06400
Hornerin (HRNR) S100-fused protein family; S-100 family Q86YZ3
Synaptotagmin-14 (SYT14) Synaptotagmin family Q8NB59
Tubulin-folding cofactor B (TBCB) TBCB family Q99426
Tubby-related protein 3 (TULP3) TUB family O75386
Arf-GAP domain and FG repeat-containing protein 1 (AGFG1) . P52594
Chromobox protein homolog 8 (CBX8) . Q9HC52
MAGE-like protein 2 (MAGEL2) . Q9UJ55
Melanoma-associated antigen 8 (MAGEA8) . P43361
Melanoma-associated antigen E1 (MAGEE1) . Q9HCI5
Myeloid differentiation primary response protein MyD88 (MYD88) . Q99836
MYND-type zinc finger-containing chromatin reader ZMYND8 (ZMYND8) . Q9ULU4
Pleckstrin homology domain-containing family O member 1 (PLEKHO1) . Q53GL0
Polyhomeotic-like protein 3 (PHC3) . Q8NDX5
Protein bassoon (BSN) . Q9UPA5
Trophinin (TRO) . Q12816
Ubiquitin-associated protein 2 (UBAP2) . Q5T6F2
YLP motif-containing protein 1 (YLPM1) . P49750
Zinc finger protein 609 (ZNF609) . O15014

The Drug(s) Related To This Target

Preclinical
Click To Hide/Show 5 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Adc-01 Small molecular drug DRJU35
Adc-03 Small molecular drug D0AN9V
Hbx19818 Small molecular drug DA0OZ2
P22077 Small molecular drug D2K6DU
P5091 Small molecular drug DV3KC5
Patented
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pmid26077642-compound-vif1 Peptide D0PT1W
Pmid26077642-compound-vif2 Peptide D03EML

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
4 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
5 An Activity-Based Oxaziridine Platform for Identifying and Developing Covalent Ligands for Functional Allosteric Methionine Sites: Redox-Dependent Inhibition of Cyclin-Dependent Kinase 4. J Am Chem Soc. 2022 Dec 21;144(50):22890-22901. doi: 10.1021/jacs.2c04039. Epub 2022 Dec 9.
6 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
7 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
8 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
9 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
10 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
11 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
12 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
13 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
14 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
15 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
16 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096
17 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
18 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
19 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
20 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
21 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
22 Site-Specific Activity-Based Protein Profiling Using Phosphonate Handles. Mol Cell Proteomics. 2023 Jan;22(1):100455. doi: 10.1016/j.mcpro.2022.100455. Epub 2022 Nov 24.
Mass spectrometry data entry: PXD036569
23 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
24 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
25 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
26 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
27 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
28 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
29 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
30 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
31 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
32 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
33 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
34 Proteome-wide covalent ligand discovery in native biological systems. Nature. 2016 Jun 23;534(7608):570-4. doi: 10.1038/nature18002. Epub 2016 Jun 15.
35 2-Sulfonylpyridines as Tunable, Cysteine-Reactive Electrophiles. J Am Chem Soc. 2020 May 13;142(19):8972-8979. doi: 10.1021/jacs.0c02721. Epub 2020 Apr 29.
36 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.