General Information of Experiment

Probe Name TFBX  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Abegg_cp(-)-11  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 12 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 7.6
 LDTP04547  Nuclear pore complex protein Nup98-Nup96 (NUP98) C1347 6.4
 LDTP07214  Mitochondrial amidoxime-reducing component 1 (MTARC1) C300 3.3
 LDTP06188  Ribosome biogenesis protein BMS1 homolog (BMS1) C725 2.9
 LDTP09962  Ubiquitin carboxyl-terminal hydrolase 7 (USP7) C702 2.8
 LDTP04103  Dual specificity mitogen-activated protein kinase kinase 3 (MAP2K3) C305 2.5
 LDTP07750  Nicotinate phosphoribosyltransferase (NAPRT) C463 2.2
 LDTP10335  Diphosphoinositol polyphosphate phosphohydrolase 3-beta (NUDT11) C131 2.1
 LDTP01333  Isocitrate dehydrogenase [NADP] cytoplasmic (IDH1) C269 2.1
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 2.1
 LDTP02342  Dihydropteridine reductase (QDPR) C161 2.0
 LDTP05782  26S proteasome non-ATPase regulatory subunit 2 (PSMD2) C448 2.0
Transporter and channel
Click to Show/Hide to Show 3 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP04393  Annexin A11 (ANXA11) C384 4.5
 LDTP00287  Exocyst complex component 5 (EXOC5) C111 3.1
 LDTP13634  Sorting nexin-12 (SNX12) C67 2.0
Other
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP14980  RRP12-like protein (RRP12) C839 12.9
 LDTP14011  Nucleolar complex protein 2 homolog (NOC2L) C561 4.8
 LDTP16096  RNA-binding protein 12 (RBM12) C545 3.9
 LDTP16285  Transducin beta-like protein 2 (TBL2) C44 3.1
 LDTP03321  Small ribosomal subunit protein eS12 (RPS12) C92 2.7
 LDTP06024  Coactosin-like protein (COTL1) C10 2.7
 LDTP07872  Intermembrane lipid transfer protein VPS13C (VPS13C) C2159 2.7
 LDTP01932  Prelamin-A/C (LMNA) C522 2.5
 LDTP05027  Large ribosomal subunit protein uL2 (RPL8) C195 2.4
 LDTP09565  General transcription factor 3C polypeptide 2 (GTF3C2) C310 2.3
 LDTP06181  Structural maintenance of chromosomes protein 1A (SMC1A) C556 2.2
 LDTP08573  Ankyrin repeat and KH domain-containing protein 1 (ANKHD1) C213 2.2
 LDTP03619  Stress-induced-phosphoprotein 1 (STIP1) C26 2.2
 LDTP05008  Large ribosomal subunit protein uL14 (RPL23) C125 2.2
 LDTP03030  Annexin A7 (ANXA7) C413 2.2
 LDTP03106  Cysteine and glycine-rich protein 1 (CSRP1) C25 2.2
 LDTP10284  Multivesicular body subunit 12A (MVB12A) C231 2.1
 LDTP07335  Rho GTPase-activating protein 17 (ARHGAP17) C43 2.1
 LDTP04997  Small ribosomal subunit protein eS4, X isoform (RPS4X) C41 2.1
 LDTP06292  Rab3 GTPase-activating protein catalytic subunit (RAB3GAP1) C873 2.0
 LDTP02595  Polyadenylate-binding protein 1 (PABPC1) C128 2.0

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255