Details of the Target

General Information of Target

Target ID LDTP10335
Target Name Diphosphoinositol polyphosphate phosphohydrolase 3-beta (NUDT11)
Gene Name NUDT11
Gene ID 55190
Synonyms
APS1; DIPP3B; Diphosphoinositol polyphosphate phosphohydrolase 3-beta; DIPP-3-beta; DIPP3-beta; hDIPP3beta; EC 3.6.1.52; Diadenosine 5',5'''-P1,P6-hexaphosphate hydrolase 3-beta; Diadenosine hexaphosphate hydrolase; AMP-forming); EC 3.6.1.60; Nucleoside diphosphate-linked moiety X motif 11; Nudix motif 11; hAps1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEGTAEAPLENGGGGDSGAGALERGVAPIKRQYLTTKEQFHQFLEAKGQEKTCRETEVG
DPAGNELAEPEAKRIRLEDGQTADGQTEEAAEPGEQLQTQKRARGQNKGRPHVKPTNYDK
NRLCPSLIQESAAKCFFGDRCRFLHDVGRYLETKPADLGPRCVLFETFGRCPYGVTCRFA
GAHLRPEGQNLVQEELAARGTQPPSIRNGLDKALQQQLRKREVRFERAEQALRRFSQGPT
PAAAVPEGTAAEGAPRQENCGAQQVPAGPGTSTPPSSPVRTCGPLTDEDVVRLRPCEKKR
LDIRGKLYLAPLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQMSEWALLKRHQCED
IFGVQLEGAFPDTMTKCAELLSRTVEVDFVDINVGCPIDLVYKKGGGCALMNRSTKFQQI
VRGMNQVLDVPLTVKIRTGVQERVNLAHRLLPELRDWGVALVTLHGRSREQRYTKLADWQ
YIEECVQAASPMPLFGNGDILSFEDANRAMQTGVTGIMIARGALLKPWLFTEIKEQRHWD
ISSSERLDILRDFTNYGLEHWGSDTQGVEKTRRFLLEWLSFLCRYVPVGLLERLPQRINE
RPPYYLGRDYLETLMASQKAADWIRISEMLLGPVPPSFAFLPKHKANAYK
Target Bioclass
Enzyme
Family
Nudix hydrolase family, DIPP subfamily
Subcellular location
Cytoplasm
Function
Cleaves a beta-phosphate from the diphosphate groups in PP-InsP5 (diphosphoinositol pentakisphosphate), suggesting that it may play a role in signal transduction. Also able to catalyze the hydrolysis of dinucleoside oligophosphates, with Ap6A and Ap5A being the preferred substrates. The major reaction products are ADP and p4a from Ap6A and ADP and ATP from Ap5A. Also able to hydrolyze 5-phosphoribose 1-diphosphate.
Uniprot ID
Q96G61
Ensemble ID
ENST00000375992.4
HGNC ID
HGNC:18011
ChEMBL ID
CHEMBL4296042

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C131(8.25)  LDD2157  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C80(1.91)  LDD3333  [3]
AHL-Pu-1
 Probe Info  		C131(4.91)  LDD0168  [4]
HHS-475
 Probe Info  		Y67(0.77)  LDD0264  [5]
TFBX
 Probe Info  		C131(2.15)  LDD0313  [6]
ATP probe
 Probe Info  		K133(0.00); K17(0.00)  LDD0199  [7]
HHS-465
 Probe Info  		N.A.  LDD2240  [8]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0025  4SU-RNA HEK-293T C131(4.91)  LDD0168  [4]
 LDCM0026  4SU-RNA+native RNA HEK-293T C131(8.65)  LDD0169  [4]
 LDCM0563  Abegg_cp(+)-11 HeLa C131(2.39)  LDD0314  [6]
 LDCM0562  Abegg_cp(-)-11 HeLa C131(2.15)  LDD0313  [6]
 LDCM0116  HHS-0101 DM93 Y67(0.77)  LDD0264  [5]
 LDCM0117  HHS-0201 DM93 Y67(0.82)  LDD0265  [5]
 LDCM0118  HHS-0301 DM93 Y67(0.74)  LDD0266  [5]
 LDCM0119  HHS-0401 DM93 Y67(1.07)  LDD0267  [5]
 LDCM0120  HHS-0701 DM93 Y67(0.90)  LDD0268  [5]
 LDCM0022  KB02 697 C80(1.67)  LDD2245  [3]
 LDCM0023  KB03 697 C80(2.50)  LDD2662  [3]
 LDCM0024  KB05 MOLM-13 C80(1.91)  LDD3333  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA damage-inducible transcript 4-like protein (DDIT4L) DDIT4 family Q96D03

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
6 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010