Details of the Competitor

General Information of Competitor

Competitor ID
LDCM0563
Competitor Name
Abegg_cp(+)-11
Structure
2D MOL
Ro5 Violations (Lipinski): 0 Molecular Weight (mw) 332.396
Lipid-water partition coefficient (xlogp) 2.7497
Rotatable Bond Count (rotbonds) 1
Hydrogen Bond Donor Count (hbonddonor) 3
Hydrogen Bond Acceptor Count (hbondacc) 4
Chemical Identifiers
Formula
C19H24O5
Canonical SMILES
CC1(C)C=C2C(=O)C(O)=C3C(C)(C(=O)O)CCC4CC34C2(O)CC1
InChI
InChI=1S/C19H24O5/c1-16(2)6-7-19(24)11(9-16)12(20)13(21)14-17(3,15(22)23)5-4-10-8-18(10,14)19/h9-10,21,24H,4-8H2,1-3H3,(H,22,23)/t10-,17-,18-,19+/m1/s1
InChIKey
ZNKDJXXXBLHJPB-FLXVQEJRSA-N

The Competitor Interaction Atlas

Probe(s) Related This Competitor

ABPP Probe
Click To Hide/Show 1 Probe Related to This Competitor
Probe Name Structure Concentration Cell-system Ref
TFBX
 Probe Info  		100 uM Human endocervical adenocarcinoma cell lysate (HeLa) [1]

Target(s) List of this Competitor

22 Enzyme Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
26S proteasome regulatory subunit 10B (PSMC6) LDTP04987 8.16  LDD0314 
6-phosphogluconate dehydrogenase, decarboxylating (PGD) LDTP04499 2.17  LDD0314 
Acyl-CoA (8-3)-desaturase (FADS1) LDTP00968 2.10  LDD0314 
Acyl-coenzyme A thioesterase 1 (ACOT1) LDTP08209 2.53  LDD0314 
Aflatoxin B1 aldehyde reductase member 4 (AKR7L) LDTP15563 2.19  LDD0314 
BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) LDTP05716 2.28  LDD0314 
CTP synthase 1 (CTPS1) LDTP02922 2.43  LDD0314 
Diphosphoinositol polyphosphate phosphohydrolase 3-beta (NUDT11) LDTP10335 2.39  LDD0314 
DNA ligase 1 (LIG1) LDTP02971 13.94  LDD0314 
DNA replication licensing factor MCM6 (MCM6) LDTP06150 41.18  LDD0314 
Kinesin-like protein KIF1C (KIF1C) LDTP00895 2.50  LDD0314 
Pachytene checkpoint protein 2 homolog (TRIP13) LDTP06432 2.46  LDD0314 
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) LDTP05877 2.24  LDD0314 
Peptidyl-tRNA hydrolase (PTRH1) LDTP17604 2.08  LDD0314 
Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1) LDTP09390 2.20  LDD0314 
Pre-mRNA-processing factor 19 (PRPF19) LDTP13623 2.02  LDD0314 
Probable ATP-dependent RNA helicase DDX23 (DDX23) LDTP11248 2.33  LDD0314 
Probable ATP-dependent RNA helicase DDX28 (DDX28) LDTP12633 2.11  LDD0314 
Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) LDTP05917 2.04  LDD0314 
Small ribosomal subunit protein uS3 (RPS3) LDTP03223 7.13  LDD0314 
Squalene synthase (FDFT1) LDTP03842 2.09  LDD0314 
Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) LDTP05070 2.21  LDD0314 
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⏷ Show the Full List of 22 Enzyme
5 Transporter and channel Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Annexin A11 (ANXA11) LDTP04393 3.22  LDD0314 
Exocyst complex component 5 (EXOC5) LDTP00287 3.43  LDD0314 
Exportin-T (XPOT) LDTP00810 2.02  LDD0314 
Filamin-A (FLNA) LDTP03107 2.43  LDD0314 
Vacuolar protein sorting-associated protein 35 (VPS35) LDTP10741 34.24  LDD0314 
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1 Transcription factor Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Non-POU domain-containing octamer-binding protein (NONO) LDTP06341 2.31  LDD0314 
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15 Other Competed by This Competitor
Target Name Target ID Binding Ratio Interaction ID
Actin filament-associated protein 1 (AFAP1) LDTP08885 2.16  LDD0314 
Coiled-coil domain-containing protein 25 (CCDC25) LDTP08339 3.29  LDD0314 
Eukaryotic translation initiation factor 1 (EIF1) LDTP03953 2.28  LDD0314 
Hepatoma-derived growth factor-related protein 2 (HDGFL2) LDTP08081 2.01  LDD0314 
Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) LDTP17065 2.21  LDD0314 
Insulin receptor substrate 2 (IRS2) LDTP14059 2.45  LDD0314 
Integrator complex subunit 4 (INTS4) LDTP10402 3.72  LDD0314 
Large ribosomal subunit protein uL5 (RPL11) LDTP05026 2.21  LDD0314 
Microtubule-associated protein 4 (MAP4) LDTP03404 2.14  LDD0314 
Protein diaphanous homolog 3 (DIAPH3) LDTP12596 2.11  LDD0314 
Protein MIS12 homolog (MIS12) LDTP11685 2.24  LDD0314 
Protein scribble homolog (SCRIB) LDTP06062 2.10  LDD0314 
Protein unc-45 homolog A (UNC45A) LDTP11890 3.69  LDD0314 
Ribosome biogenesis protein BRX1 homolog (BRIX1) LDTP15609 2.35  LDD0314 
Small ribosomal subunit protein eS12 (RPS12) LDTP03321 2.19  LDD0314 
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⏷ Show the Full List of 15 Other

Full Information of The Labelling Profiles of This Competitor

Quantification: Probe vs (Probe+Competitor)
  
Experiment 1 Reporting the Labelling Profiles of This Probe
REF [1]
Probe concentration 100 uM
Quantitative Method LFQ
Competitor Name Abegg_cp(+)-11
Competitor Concentration 30 uM
In Vitro Experiment Model Model Type
Cell lysate
Derived Tissue
Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)
Interaction Atlas ID  LDD0314  Download The Altas

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255