General Information of Experiment

Probe Name TFBX  Probe Info 
Probe concentration 100 uM
Criteria Quantification: Probe vs (Probe+Competitor)
Quantitative Method
LFQ
Competitor Name Abegg_cp(+)-11  Competitor Info 
Competitor Concentration 30 uM
In Vivo Experiment Model Model Type Cell lysate
Derived Tissue Cervix uteri
Disease Model Endocervical adenocarcinoma [ICD-11:2C77]
Model Name Human endocervical adenocarcinoma cell lysate (HeLa)

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06150  DNA replication licensing factor MCM6 (MCM6) C721 41.2
 LDTP02971  DNA ligase 1 (LIG1) C434 13.9
 LDTP04987  26S proteasome regulatory subunit 10B (PSMC6) C170 8.2
 LDTP03223  Small ribosomal subunit protein uS3 (RPS3) C97 7.1
 LDTP08209  Acyl-coenzyme A thioesterase 1 (ACOT1) C339 2.5
 LDTP00895  Kinesin-like protein KIF1C (KIF1C) C229 2.5
 LDTP06432  Pachytene checkpoint protein 2 homolog (TRIP13) C14 2.5
 LDTP02922  CTP synthase 1 (CTPS1) C362 2.4
 LDTP10335  Diphosphoinositol polyphosphate phosphohydrolase 3-beta (NUDT11) C131 2.4
 LDTP11248  Probable ATP-dependent RNA helicase DDX23 (DDX23) C409 2.3
 LDTP05716  BCL2/adenovirus E1B 19 kDa protein-interacting protein 2 (BNIP2) C229 2.3
 LDTP05877  Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) C394 2.2
 LDTP05070  Ubiquitin-conjugating enzyme E2 L3 (UBE2L3) C86 2.2
 LDTP09390  Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1) C359 2.2
 LDTP15563  Aflatoxin B1 aldehyde reductase member 4 (AKR7L) C186 2.2
 LDTP04499  6-phosphogluconate dehydrogenase, decarboxylating (PGD) C289 2.2
 LDTP12633  Probable ATP-dependent RNA helicase DDX28 (DDX28) C170 2.1
 LDTP00968  Acyl-CoA (8-3)-desaturase (FADS1) C407 2.1
 LDTP03842  Squalene synthase (FDFT1) C147 2.1
 LDTP17604  Peptidyl-tRNA hydrolase (PTRH1) C20 2.1
 LDTP05917  Receptor-interacting serine/threonine-protein kinase 1 (RIPK1) C34 2.0
 LDTP13623  Pre-mRNA-processing factor 19 (PRPF19) C114 2.0
Transporter and channel
Click to Show/Hide to Show 5 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10741  Vacuolar protein sorting-associated protein 35 (VPS35) C653 34.2
 LDTP00287  Exocyst complex component 5 (EXOC5) C111 3.4
 LDTP04393  Annexin A11 (ANXA11) C384 3.2
 LDTP03107  Filamin-A (FLNA) C2199 2.4
 LDTP00810  Exportin-T (XPOT) C38 2.0
Transcription factor
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP06341  Non-POU domain-containing octamer-binding protein (NONO) C145 2.3
Other
Click to Show/Hide to Show 15 Protein Related to This Bioclass
Target ID Target Name Binding Sites Binding Ratio
 LDTP10402  Integrator complex subunit 4 (INTS4) C44 3.7
 LDTP11890  Protein unc-45 homolog A (UNC45A) C223 3.7
 LDTP08339  Coiled-coil domain-containing protein 25 (CCDC25) C83 3.3
 LDTP14059  Insulin receptor substrate 2 (IRS2) C409 2.5
 LDTP15609  Ribosome biogenesis protein BRX1 homolog (BRIX1) C158 2.4
 LDTP03953  Eukaryotic translation initiation factor 1 (EIF1) C94 2.3
 LDTP11685  Protein MIS12 homolog (MIS12) C133 2.2
 LDTP05026  Large ribosomal subunit protein uL5 (RPL11) C150 2.2
 LDTP17065  Heterogeneous nuclear ribonucleoprotein U-like protein 2 (HNRNPUL2) C538 2.2
 LDTP03321  Small ribosomal subunit protein eS12 (RPS12) C92 2.2
 LDTP08885  Actin filament-associated protein 1 (AFAP1) C622 2.2
 LDTP03404  Microtubule-associated protein 4 (MAP4) C1008 2.1
 LDTP12596  Protein diaphanous homolog 3 (DIAPH3) C1125 2.1
 LDTP06062  Protein scribble homolog (SCRIB) C22 2.1
 LDTP08081  Hepatoma-derived growth factor-related protein 2 (HDGFL2) C631 2.0

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255