Details of the Target

General Information of Target

Target ID LDTP06432
Target Name Pachytene checkpoint protein 2 homolog (TRIP13)
Gene Name TRIP13
Gene ID 9319
Synonyms
PCH2; Pachytene checkpoint protein 2 homolog; Human papillomavirus type 16 E1 protein-binding protein; 16E1-BP; HPV16 E1 protein-binding protein; Thyroid hormone receptor interactor 13; Thyroid receptor-interacting protein 13; TR-interacting protein 13; TRIP-13
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MDEAVGDLKQALPCVAESPTVHVEVHQRGSSTAKKEDINLSVRKLLNRHNIVFGDYTWTE
FDEPFLTRNVQSVSIIDTELKVKDSQPIDLSACTVALHIFQLNEDGPSSENLEEETENII
AANHWVLPAAEFHGLWDSLVYDVEVKSHLLDYVMTTLLFSDKNVNSNLITWNRVVLLHGP
PGTGKTSLCKALAQKLTIRLSSRYRYGQLIEINSHSLFSKWFSESGKLVTKMFQKIQDLI
DDKDALVFVLIDEVESLTAARNACRAGTEPSDAIRVVNAVLTQIDQIKRHSNVVILTTSN
ITEKIDVAFVDRADIKQYIGPPSAAAIFKIYLSCLEELMKCQIIYPRQQLLTLRELEMIG
FIENNVSKLSLLLNDISRKSEGLSGRVLRKLPFLAHALYVQAPTVTIEGFLQALSLAVDK
QFEERKKLAAYI
Target Bioclass
Enzyme
Family
AAA ATPase family, PCH2 subfamily
Function
Plays a key role in chromosome recombination and chromosome structure development during meiosis. Required at early steps in meiotic recombination that leads to non-crossovers pathways. Also needed for efficient completion of homologous synapsis by influencing crossover distribution along the chromosomes affecting both crossovers and non-crossovers pathways. Also required for development of higher-order chromosome structures and is needed for synaptonemal-complex formation. In males, required for efficient synapsis of the sex chromosomes and for sex body formation. Promotes early steps of the DNA double-strand breaks (DSBs) repair process upstream of the assembly of RAD51 complexes. Required for depletion of HORMAD1 and HORMAD2 from synapsed chromosomes. Plays a role in mitotic spindle assembly checkpoint (SAC) activation.
Uniprot ID
Q15645
Ensemble ID
ENST00000166345.8
HGNC ID
HGNC:12307

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
8505C SNV: p.E115Q DBIA    Probe Info 
CCK81 SNV: p.G382C DBIA    Probe Info 
LS180 SNV: p.G106D DBIA    Probe Info 
LU65 SNV: p.I198T DBIA    Probe Info 
MIAPACA2 SNV: p.K9R .
NCIH1155 SNV: p.R354Ter DBIA    Probe Info 
NCIH2122 SNV: p.L239F .
SNU423 SNV: p.L168V DBIA    Probe Info 
TCCSUP SNV: p.G409R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 33 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		15.00  LDD0402  [1]
CHEMBL5175495
 Probe Info  		6.28  LDD0196  [2]
TH211
 Probe Info  		Y318(15.68); Y56(6.29)  LDD0257  [3]
TH216
 Probe Info  		Y318(20.00)  LDD0259  [3]
AHL-Pu-1
 Probe Info  		C14(3.07)  LDD0169  [4]
EA-probe
 Probe Info  		N.A.  LDD0440  [5]
DBIA
 Probe Info  		C14(77.68)  LDD0209  [6]
ATP probe
 Probe Info  		K288(0.00); K185(0.00); K316(0.00)  LDD0199  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C341(0.00); C334(0.00); C14(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		N.A.  LDD0032  [9]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [10]
Lodoacetamide azide
 Probe Info  		C341(0.00); C334(0.00); C14(0.00)  LDD0037  [8]
BTD
 Probe Info  		N.A.  LDD0004  [11]
JW-RF-010
 Probe Info  		C341(0.00); C14(0.00); C264(0.00)  LDD0026  [12]
NAIA_4
 Probe Info  		N.A.  LDD2226  [13]
TFBX
 Probe Info  		C334(0.00); C341(0.00); C264(0.00)  LDD0027  [12]
WYneN
 Probe Info  		N.A.  LDD0021  [11]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
IPM
 Probe Info  		C341(0.00); C14(0.00)  LDD0005  [11]
NHS
 Probe Info  		N.A.  LDD0010  [11]
NPM
 Probe Info  		N.A.  LDD0016  [11]
STPyne
 Probe Info  		N.A.  LDD0009  [11]
VSF
 Probe Info  		C341(0.00); C14(0.00)  LDD0007  [11]
Phosphinate-6
 Probe Info  		C189(0.00); C264(0.00); C14(0.00)  LDD0018  [15]
Ox-W18
 Probe Info  		N.A.  LDD2175  [16]
1c-yne
 Probe Info  		N.A.  LDD0228  [17]
Acrolein
 Probe Info  		H290(0.00); C334(0.00); H178(0.00)  LDD0217  [18]
Methacrolein
 Probe Info  		C14(0.00); C341(0.00)  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [19]
AOyne
 Probe Info  		15.00  LDD0443  [20]
NAIA_5
 Probe Info  		C334(0.00); C14(0.00)  LDD2223  [13]
HHS-465
 Probe Info  		N.A.  LDD2240  [21]
PAL-AfBPP Probe
Click To Hide/Show 11 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C022
 Probe Info  		6.68  LDD1728  [22]
C143
 Probe Info  		20.82  LDD1825  [22]
C169
 Probe Info  		31.34  LDD1849  [22]
C201
 Probe Info  		26.54  LDD1877  [22]
C204
 Probe Info  		6.23  LDD1879  [22]
FFF probe12
 Probe Info  		9.62  LDD0473  [23]
FFF probe13
 Probe Info  		6.07  LDD0476  [23]
FFF probe2
 Probe Info  		6.38  LDD0463  [23]
FFF probe3
 Probe Info  		12.25  LDD0465  [23]
STS-1
 Probe Info  		N.A.  LDD0136  [24]
STS-2
 Probe Info  		N.A.  LDD0138  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0026  4SU-RNA+native RNA HEK-293T C14(3.07)  LDD0169  [4]
 LDCM0563  Abegg_cp(+)-11 HeLa C14(2.46)  LDD0314  [12]
 LDCM0214  AC1 HCT 116 C14(1.46); C334(0.66); C341(0.92)  LDD0531  [25]
 LDCM0215  AC10 HCT 116 C14(1.31); C334(0.80); C341(0.94)  LDD0532  [25]
 LDCM0216  AC100 HCT 116 C341(1.31)  LDD0533  [25]
 LDCM0217  AC101 HCT 116 C341(1.04)  LDD0534  [25]
 LDCM0218  AC102 HCT 116 C341(1.15)  LDD0535  [25]
 LDCM0219  AC103 HCT 116 C341(1.09)  LDD0536  [25]
 LDCM0220  AC104 HCT 116 C341(1.21)  LDD0537  [25]
 LDCM0221  AC105 HCT 116 C341(1.17)  LDD0538  [25]
 LDCM0222  AC106 HCT 116 C341(1.15)  LDD0539  [25]
 LDCM0223  AC107 HCT 116 C341(1.07)  LDD0540  [25]
 LDCM0224  AC108 HCT 116 C341(1.15)  LDD0541  [25]
 LDCM0225  AC109 HCT 116 C341(1.01)  LDD0542  [25]
 LDCM0226  AC11 HCT 116 C14(1.03); C334(0.74); C341(0.92)  LDD0543  [25]
 LDCM0227  AC110 HCT 116 C341(1.04)  LDD0544  [25]
 LDCM0228  AC111 HCT 116 C341(1.07)  LDD0545  [25]
 LDCM0229  AC112 HCT 116 C341(1.00)  LDD0546  [25]
 LDCM0230  AC113 HCT 116 C334(1.01); C341(0.97)  LDD0547  [25]
 LDCM0231  AC114 HCT 116 C334(0.97); C341(0.93)  LDD0548  [25]
 LDCM0232  AC115 HCT 116 C334(0.99); C341(1.06)  LDD0549  [25]
 LDCM0233  AC116 HCT 116 C334(0.78); C341(1.04)  LDD0550  [25]
 LDCM0234  AC117 HCT 116 C334(0.92); C341(0.95)  LDD0551  [25]
 LDCM0235  AC118 HCT 116 C334(1.00); C341(0.90)  LDD0552  [25]
 LDCM0236  AC119 HCT 116 C334(0.88); C341(0.91)  LDD0553  [25]
 LDCM0237  AC12 HCT 116 C14(1.41); C334(0.84); C341(1.01)  LDD0554  [25]
 LDCM0238  AC120 HCT 116 C334(0.72); C341(0.80)  LDD0555  [25]
 LDCM0239  AC121 HCT 116 C334(0.88); C341(0.92)  LDD0556  [25]
 LDCM0240  AC122 HCT 116 C334(0.91); C341(0.95)  LDD0557  [25]
 LDCM0241  AC123 HCT 116 C334(0.97); C341(0.92)  LDD0558  [25]
 LDCM0242  AC124 HCT 116 C334(1.26); C341(0.87)  LDD0559  [25]
 LDCM0243  AC125 HCT 116 C334(0.97); C341(0.99)  LDD0560  [25]
 LDCM0244  AC126 HCT 116 C334(0.82); C341(1.02)  LDD0561  [25]
 LDCM0245  AC127 HCT 116 C334(0.88); C341(0.89)  LDD0562  [25]
 LDCM0246  AC128 HCT 116 C341(1.37)  LDD0563  [25]
 LDCM0247  AC129 HCT 116 C341(1.37)  LDD0564  [25]
 LDCM0249  AC130 HCT 116 C341(1.38)  LDD0566  [25]
 LDCM0250  AC131 HCT 116 C341(1.28)  LDD0567  [25]
 LDCM0251  AC132 HCT 116 C341(1.58)  LDD0568  [25]
 LDCM0252  AC133 HCT 116 C341(1.35)  LDD0569  [25]
 LDCM0253  AC134 HCT 116 C341(1.40)  LDD0570  [25]
 LDCM0254  AC135 HCT 116 C341(1.58)  LDD0571  [25]
 LDCM0255  AC136 HCT 116 C341(1.34)  LDD0572  [25]
 LDCM0256  AC137 HCT 116 C341(1.28)  LDD0573  [25]
 LDCM0257  AC138 HCT 116 C341(1.41)  LDD0574  [25]
 LDCM0258  AC139 HCT 116 C341(1.26)  LDD0575  [25]
 LDCM0259  AC14 HCT 116 C14(1.25); C334(0.87); C341(1.08)  LDD0576  [25]
 LDCM0260  AC140 HCT 116 C341(1.70)  LDD0577  [25]
 LDCM0261  AC141 HCT 116 C341(1.69)  LDD0578  [25]
 LDCM0262  AC142 HCT 116 C341(1.53)  LDD0579  [25]
 LDCM0263  AC143 HCT 116 C341(0.99)  LDD0580  [25]
 LDCM0264  AC144 HCT 116 C341(0.84)  LDD0581  [25]
 LDCM0265  AC145 HCT 116 C341(1.01)  LDD0582  [25]
 LDCM0266  AC146 HCT 116 C341(0.97)  LDD0583  [25]
 LDCM0267  AC147 HCT 116 C341(1.07)  LDD0584  [25]
 LDCM0268  AC148 HCT 116 C341(1.02)  LDD0585  [25]
 LDCM0269  AC149 HCT 116 C341(0.93)  LDD0586  [25]
 LDCM0270  AC15 HCT 116 C334(0.77); C341(0.98); C14(0.98)  LDD0587  [25]
 LDCM0271  AC150 HCT 116 C341(0.97)  LDD0588  [25]
 LDCM0272  AC151 HCT 116 C341(1.02)  LDD0589  [25]
 LDCM0273  AC152 HCT 116 C341(0.86)  LDD0590  [25]
 LDCM0274  AC153 HCT 116 C341(1.17)  LDD0591  [25]
 LDCM0621  AC154 HCT 116 C341(1.14)  LDD2158  [25]
 LDCM0622  AC155 HCT 116 C341(1.06)  LDD2159  [25]
 LDCM0623  AC156 HCT 116 C341(0.81)  LDD2160  [25]
 LDCM0624  AC157 HCT 116 C341(1.58)  LDD2161  [25]
 LDCM0276  AC17 HCT 116 C341(1.14)  LDD0593  [25]
 LDCM0277  AC18 HCT 116 C341(1.31)  LDD0594  [25]
 LDCM0278  AC19 HCT 116 C341(1.12)  LDD0595  [25]
 LDCM0279  AC2 HCT 116 C334(0.84); C341(1.02); C14(1.13)  LDD0596  [25]
 LDCM0280  AC20 HCT 116 C341(1.18)  LDD0597  [25]
 LDCM0281  AC21 HCT 116 C341(1.11)  LDD0598  [25]
 LDCM0282  AC22 HCT 116 C341(0.96)  LDD0599  [25]
 LDCM0283  AC23 HCT 116 C341(1.40)  LDD0600  [25]
 LDCM0284  AC24 HCT 116 C341(1.07)  LDD0601  [25]
 LDCM0285  AC25 HCT 116 C341(1.00)  LDD0602  [25]
 LDCM0286  AC26 HCT 116 C341(1.28)  LDD0603  [25]
 LDCM0287  AC27 HCT 116 C341(0.94)  LDD0604  [25]
 LDCM0288  AC28 HCT 116 C341(1.01)  LDD0605  [25]
 LDCM0289  AC29 HCT 116 C341(0.87)  LDD0606  [25]
 LDCM0290  AC3 HCT 116 C334(1.01); C14(1.06); C341(1.20)  LDD0607  [25]
 LDCM0291  AC30 HCT 116 C341(0.90)  LDD0608  [25]
 LDCM0292  AC31 HCT 116 C341(1.07)  LDD0609  [25]
 LDCM0293  AC32 HCT 116 C341(0.91)  LDD0610  [25]
 LDCM0294  AC33 HCT 116 C341(0.92)  LDD0611  [25]
 LDCM0295  AC34 HCT 116 C341(0.91)  LDD0612  [25]
 LDCM0296  AC35 HCT 116 C341(1.00); C334(1.17)  LDD0613  [25]
 LDCM0297  AC36 HCT 116 C341(0.71); C334(1.29)  LDD0614  [25]
 LDCM0298  AC37 HCT 116 C341(0.79); C334(1.07)  LDD0615  [25]
 LDCM0299  AC38 HCT 116 C341(0.78); C334(1.19)  LDD0616  [25]
 LDCM0300  AC39 HCT 116 C341(0.96); C334(1.04)  LDD0617  [25]
 LDCM0301  AC4 HCT 116 C334(0.79); C341(1.13); C14(1.40)  LDD0618  [25]
 LDCM0302  AC40 HCT 116 C341(0.85); C334(1.02)  LDD0619  [25]
 LDCM0303  AC41 HCT 116 C341(0.73); C334(1.05)  LDD0620  [25]
 LDCM0304  AC42 HCT 116 C341(0.95); C334(1.18)  LDD0621  [25]
 LDCM0305  AC43 HCT 116 C341(0.84); C334(1.13)  LDD0622  [25]
 LDCM0306  AC44 HCT 116 C341(0.77); C334(1.10)  LDD0623  [25]
 LDCM0307  AC45 HCT 116 C341(0.81); C334(1.04)  LDD0624  [25]
 LDCM0308  AC46 HCT 116 C341(0.78)  LDD0625  [25]
 LDCM0309  AC47 HCT 116 C341(0.94)  LDD0626  [25]
 LDCM0310  AC48 HCT 116 C341(0.97)  LDD0627  [25]
 LDCM0311  AC49 HCT 116 C341(0.97)  LDD0628  [25]
 LDCM0312  AC5 HCT 116 C334(0.87); C341(1.26); C14(1.38)  LDD0629  [25]
 LDCM0313  AC50 HCT 116 C341(0.97)  LDD0630  [25]
 LDCM0314  AC51 HCT 116 C341(1.06)  LDD0631  [25]
 LDCM0315  AC52 HCT 116 C341(0.89)  LDD0632  [25]
 LDCM0316  AC53 HCT 116 C341(1.02)  LDD0633  [25]
 LDCM0317  AC54 HCT 116 C341(0.98)  LDD0634  [25]
 LDCM0318  AC55 HCT 116 C341(1.04)  LDD0635  [25]
 LDCM0319  AC56 HCT 116 C341(1.04)  LDD0636  [25]
 LDCM0320  AC57 HCT 116 C341(0.91); C334(0.93)  LDD0637  [25]
 LDCM0321  AC58 HCT 116 C341(0.84); C334(1.04)  LDD0638  [25]
 LDCM0322  AC59 HCT 116 C341(0.94); C334(1.03)  LDD0639  [25]
 LDCM0323  AC6 HCT 116 C334(0.88); C14(1.04); C341(1.09)  LDD0640  [25]
 LDCM0324  AC60 HCT 116 C341(0.95); C334(1.01)  LDD0641  [25]
 LDCM0325  AC61 HCT 116 C341(0.94); C334(1.00)  LDD0642  [25]
 LDCM0326  AC62 HCT 116 C341(1.02); C334(1.15)  LDD0643  [25]
 LDCM0327  AC63 HCT 116 C341(0.91); C334(0.95)  LDD0644  [25]
 LDCM0328  AC64 HCT 116 C334(0.97); C341(1.02)  LDD0645  [25]
 LDCM0329  AC65 HCT 116 C341(1.04); C334(1.19)  LDD0646  [25]
 LDCM0330  AC66 HCT 116 C341(1.02); C334(1.18)  LDD0647  [25]
 LDCM0331  AC67 HCT 116 C341(1.01); C334(1.16)  LDD0648  [25]
 LDCM0332  AC68 HCT 116 C341(1.05)  LDD0649  [25]
 LDCM0333  AC69 HCT 116 C341(1.05)  LDD0650  [25]
 LDCM0334  AC7 HCT 116 C334(0.83); C341(1.07); C14(1.22)  LDD0651  [25]
 LDCM0335  AC70 HCT 116 C341(1.39)  LDD0652  [25]
 LDCM0336  AC71 HCT 116 C341(1.36)  LDD0653  [25]
 LDCM0337  AC72 HCT 116 C341(1.26)  LDD0654  [25]
 LDCM0338  AC73 HCT 116 C341(1.18)  LDD0655  [25]
 LDCM0339  AC74 HCT 116 C341(1.09)  LDD0656  [25]
 LDCM0340  AC75 HCT 116 C341(0.97)  LDD0657  [25]
 LDCM0341  AC76 HCT 116 C341(1.01)  LDD0658  [25]
 LDCM0342  AC77 HCT 116 C341(1.00)  LDD0659  [25]
 LDCM0343  AC78 HCT 116 C341(1.08)  LDD0660  [25]
 LDCM0344  AC79 HCT 116 C341(1.17)  LDD0661  [25]
 LDCM0345  AC8 HCT 116 C334(0.85); C341(1.02); C14(1.07)  LDD0662  [25]
 LDCM0346  AC80 HCT 116 C341(0.95)  LDD0663  [25]
 LDCM0347  AC81 HCT 116 C341(1.19)  LDD0664  [25]
 LDCM0348  AC82 HCT 116 C341(1.19)  LDD0665  [25]
 LDCM0365  AC98 HCT 116 C341(1.18)  LDD0682  [25]
 LDCM0366  AC99 HCT 116 C341(1.22)  LDD0683  [25]
 LDCM0248  AKOS034007472 HCT 116 C14(1.17); C334(0.92); C341(1.17)  LDD0565  [25]
 LDCM0356  AKOS034007680 HCT 116 C334(0.70); C341(0.92); C14(0.97)  LDD0673  [25]
 LDCM0275  AKOS034007705 HCT 116 C334(0.78); C14(1.18); C341(1.24)  LDD0592  [25]
 LDCM0156  Aniline NCI-H1299 11.83  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C341(1.09)  LDD2171  [25]
 LDCM0108  Chloroacetamide HeLa C14(0.00); C334(0.00); C341(0.00); H290(0.00)  LDD0222  [18]
 LDCM0632  CL-Sc Hep-G2 C14(1.07)  LDD2227  [13]
 LDCM0367  CL1 HCT 116 C341(1.00)  LDD0684  [25]
 LDCM0368  CL10 HCT 116 C341(1.10)  LDD0685  [25]
 LDCM0369  CL100 HCT 116 C334(0.80); C341(1.08); C14(1.18)  LDD0686  [25]
 LDCM0370  CL101 HCT 116 C334(0.79); C341(1.08); C14(1.28)  LDD0687  [25]
 LDCM0371  CL102 HCT 116 C334(0.86); C341(1.05); C14(1.10)  LDD0688  [25]
 LDCM0372  CL103 HCT 116 C334(0.74); C341(0.89); C14(1.13)  LDD0689  [25]
 LDCM0373  CL104 HCT 116 C334(0.75); C341(0.93); C14(1.23)  LDD0690  [25]
 LDCM0374  CL105 HCT 116 C341(1.09)  LDD0691  [25]
 LDCM0375  CL106 HCT 116 C341(1.47)  LDD0692  [25]
 LDCM0376  CL107 HCT 116 C341(1.41)  LDD0693  [25]
 LDCM0377  CL108 HCT 116 C341(1.28)  LDD0694  [25]
 LDCM0378  CL109 HCT 116 C341(1.20)  LDD0695  [25]
 LDCM0379  CL11 HCT 116 C341(1.08)  LDD0696  [25]
 LDCM0380  CL110 HCT 116 C341(0.98)  LDD0697  [25]
 LDCM0381  CL111 HCT 116 C341(1.33)  LDD0698  [25]
 LDCM0382  CL112 HCT 116 C341(0.89)  LDD0699  [25]
 LDCM0383  CL113 HCT 116 C341(0.88)  LDD0700  [25]
 LDCM0384  CL114 HCT 116 C341(0.87)  LDD0701  [25]
 LDCM0385  CL115 HCT 116 C341(0.83)  LDD0702  [25]
 LDCM0386  CL116 HCT 116 C341(0.97)  LDD0703  [25]
 LDCM0387  CL117 HCT 116 C341(0.83); C334(1.25)  LDD0704  [25]
 LDCM0388  CL118 HCT 116 C341(0.87); C334(1.09)  LDD0705  [25]
 LDCM0389  CL119 HCT 116 C341(0.83); C334(0.97)  LDD0706  [25]
 LDCM0390  CL12 HCT 116 C341(1.28)  LDD0707  [25]
 LDCM0391  CL120 HCT 116 C341(0.81); C334(0.96)  LDD0708  [25]
 LDCM0392  CL121 HCT 116 C341(0.96)  LDD0709  [25]
 LDCM0393  CL122 HCT 116 C341(0.90)  LDD0710  [25]
 LDCM0394  CL123 HCT 116 C341(0.90)  LDD0711  [25]
 LDCM0395  CL124 HCT 116 C341(0.95)  LDD0712  [25]
 LDCM0396  CL125 HCT 116 C341(0.89); C334(0.92)  LDD0713  [25]
 LDCM0397  CL126 HCT 116 C334(0.81); C341(0.89)  LDD0714  [25]
 LDCM0398  CL127 HCT 116 C341(0.97); C334(1.01)  LDD0715  [25]
 LDCM0399  CL128 HCT 116 C341(0.94); C334(1.06)  LDD0716  [25]
 LDCM0400  CL13 HCT 116 C341(1.13)  LDD0717  [25]
 LDCM0401  CL14 HCT 116 C341(1.10)  LDD0718  [25]
 LDCM0402  CL15 HCT 116 C341(1.20)  LDD0719  [25]
 LDCM0403  CL16 HCT 116 C341(0.80); C334(0.80)  LDD0720  [25]
 LDCM0404  CL17 HCT 116 C334(0.82); C341(0.86)  LDD0721  [25]
 LDCM0405  CL18 HCT 116 C334(0.72); C341(0.91)  LDD0722  [25]
 LDCM0406  CL19 HCT 116 C334(0.89); C341(0.99)  LDD0723  [25]
 LDCM0407  CL2 HCT 116 C341(1.07)  LDD0724  [25]
 LDCM0408  CL20 HCT 116 C334(0.90); C341(1.04)  LDD0725  [25]
 LDCM0409  CL21 HCT 116 C334(0.86); C341(0.94)  LDD0726  [25]
 LDCM0410  CL22 HCT 116 C341(1.15); C334(1.15)  LDD0727  [25]
 LDCM0411  CL23 HCT 116 C334(0.83); C341(0.96)  LDD0728  [25]
 LDCM0412  CL24 HCT 116 C334(0.87); C341(0.98)  LDD0729  [25]
 LDCM0413  CL25 HCT 116 C334(0.84); C341(0.96)  LDD0730  [25]
 LDCM0414  CL26 HCT 116 C334(0.86); C341(0.91)  LDD0731  [25]
 LDCM0415  CL27 HCT 116 C334(0.87); C341(1.13)  LDD0732  [25]
 LDCM0416  CL28 HCT 116 C334(0.82); C341(0.91)  LDD0733  [25]
 LDCM0417  CL29 HCT 116 C334(0.86); C341(0.99)  LDD0734  [25]
 LDCM0418  CL3 HCT 116 C341(0.98)  LDD0735  [25]
 LDCM0419  CL30 HCT 116 C334(0.77); C341(1.04)  LDD0736  [25]
 LDCM0420  CL31 HCT 116 C14(1.07); C334(0.78); C341(1.24)  LDD0737  [25]
 LDCM0421  CL32 HCT 116 C14(0.90); C334(0.72); C341(1.11)  LDD0738  [25]
 LDCM0422  CL33 HCT 116 C14(1.18); C334(0.78); C341(1.02)  LDD0739  [25]
 LDCM0423  CL34 HCT 116 C14(1.10); C334(0.84); C341(0.90)  LDD0740  [25]
 LDCM0424  CL35 HCT 116 C14(1.20); C334(0.84); C341(0.95)  LDD0741  [25]
 LDCM0425  CL36 HCT 116 C14(1.00); C334(0.78); C341(0.97)  LDD0742  [25]
 LDCM0426  CL37 HCT 116 C14(1.29); C334(0.84); C341(0.88)  LDD0743  [25]
 LDCM0428  CL39 HCT 116 C14(0.98); C334(0.73); C341(0.87)  LDD0745  [25]
 LDCM0429  CL4 HCT 116 C341(0.86)  LDD0746  [25]
 LDCM0430  CL40 HCT 116 C14(1.04); C334(0.71); C341(0.97)  LDD0747  [25]
 LDCM0431  CL41 HCT 116 C14(0.99); C334(0.85); C341(0.88)  LDD0748  [25]
 LDCM0432  CL42 HCT 116 C14(0.95); C334(0.92); C341(0.82)  LDD0749  [25]
 LDCM0433  CL43 HCT 116 C14(0.92); C334(0.80); C341(1.07)  LDD0750  [25]
 LDCM0434  CL44 HCT 116 C14(1.11); C334(0.70); C341(1.06)  LDD0751  [25]
 LDCM0435  CL45 HCT 116 C14(1.00); C334(0.81); C341(1.10)  LDD0752  [25]
 LDCM0436  CL46 HCT 116 C14(1.06); C341(1.06)  LDD0753  [25]
 LDCM0437  CL47 HCT 116 C14(1.06); C341(1.00)  LDD0754  [25]
 LDCM0438  CL48 HCT 116 C14(0.95); C341(1.05)  LDD0755  [25]
 LDCM0439  CL49 HCT 116 C14(0.77); C341(0.99)  LDD0756  [25]
 LDCM0440  CL5 HCT 116 C341(1.10)  LDD0757  [25]
 LDCM0441  CL50 HCT 116 C14(0.83); C341(1.06)  LDD0758  [25]
 LDCM0442  CL51 HCT 116 C14(0.98); C341(1.18)  LDD0759  [25]
 LDCM0443  CL52 HCT 116 C14(1.02); C341(1.07)  LDD0760  [25]
 LDCM0444  CL53 HCT 116 C14(1.24); C341(0.86)  LDD0761  [25]
 LDCM0445  CL54 HCT 116 C14(1.04); C341(1.07)  LDD0762  [25]
 LDCM0446  CL55 HCT 116 C14(0.97); C341(1.06)  LDD0763  [25]
 LDCM0447  CL56 HCT 116 C14(1.00); C341(1.00)  LDD0764  [25]
 LDCM0448  CL57 HCT 116 C14(1.16); C341(1.10)  LDD0765  [25]
 LDCM0449  CL58 HCT 116 C14(0.95); C341(1.06)  LDD0766  [25]
 LDCM0450  CL59 HCT 116 C14(0.85); C341(1.08)  LDD0767  [25]
 LDCM0451  CL6 HCT 116 C341(1.09)  LDD0768  [25]
 LDCM0452  CL60 HCT 116 C14(0.97); C341(0.99)  LDD0769  [25]
 LDCM0453  CL61 HCT 116 C334(0.88); C341(1.01)  LDD0770  [25]
 LDCM0454  CL62 HCT 116 C334(1.01); C341(0.85)  LDD0771  [25]
 LDCM0455  CL63 HCT 116 C334(0.82); C341(0.89)  LDD0772  [25]
 LDCM0456  CL64 HCT 116 C334(0.73); C341(1.02)  LDD0773  [25]
 LDCM0457  CL65 HCT 116 C334(0.88); C341(1.04)  LDD0774  [25]
 LDCM0458  CL66 HCT 116 C334(0.86); C341(0.90)  LDD0775  [25]
 LDCM0459  CL67 HCT 116 C334(0.80); C341(0.78)  LDD0776  [25]
 LDCM0460  CL68 HCT 116 C334(0.86); C341(0.82)  LDD0777  [25]
 LDCM0461  CL69 HCT 116 C334(0.67); C341(0.70)  LDD0778  [25]
 LDCM0462  CL7 HCT 116 C341(1.42)  LDD0779  [25]
 LDCM0463  CL70 HCT 116 C334(0.80); C341(0.74)  LDD0780  [25]
 LDCM0464  CL71 HCT 116 C334(0.74); C341(0.89)  LDD0781  [25]
 LDCM0465  CL72 HCT 116 C334(0.86); C341(1.02)  LDD0782  [25]
 LDCM0466  CL73 HCT 116 C334(0.74); C341(0.94)  LDD0783  [25]
 LDCM0467  CL74 HCT 116 C334(0.82); C341(0.87)  LDD0784  [25]
 LDCM0469  CL76 HCT 116 C334(0.63); C341(0.89)  LDD0786  [25]
 LDCM0470  CL77 HCT 116 C334(0.63); C341(0.87)  LDD0787  [25]
 LDCM0471  CL78 HCT 116 C334(0.66); C341(0.93)  LDD0788  [25]
 LDCM0472  CL79 HCT 116 C334(0.72); C341(0.93)  LDD0789  [25]
 LDCM0473  CL8 HCT 116 C341(0.84)  LDD0790  [25]
 LDCM0474  CL80 HCT 116 C334(0.61); C341(0.93)  LDD0791  [25]
 LDCM0475  CL81 HCT 116 C334(0.69); C341(0.99)  LDD0792  [25]
 LDCM0476  CL82 HCT 116 C334(0.72); C341(1.08)  LDD0793  [25]
 LDCM0477  CL83 HCT 116 C334(0.72); C341(0.73)  LDD0794  [25]
 LDCM0478  CL84 HCT 116 C334(0.81); C341(0.79)  LDD0795  [25]
 LDCM0479  CL85 HCT 116 C334(0.67); C341(0.74)  LDD0796  [25]
 LDCM0480  CL86 HCT 116 C334(0.67); C341(0.81)  LDD0797  [25]
 LDCM0481  CL87 HCT 116 C334(0.66); C341(0.82)  LDD0798  [25]
 LDCM0482  CL88 HCT 116 C334(0.71); C341(1.05)  LDD0799  [25]
 LDCM0483  CL89 HCT 116 C334(0.89); C341(0.99)  LDD0800  [25]
 LDCM0484  CL9 HCT 116 C341(1.12)  LDD0801  [25]
 LDCM0485  CL90 HCT 116 C334(0.83); C341(0.89)  LDD0802  [25]
 LDCM0486  CL91 HCT 116 C14(1.04); C334(0.87); C341(1.01)  LDD0803  [25]
 LDCM0487  CL92 HCT 116 C14(1.22); C334(0.77); C341(0.85)  LDD0804  [25]
 LDCM0488  CL93 HCT 116 C14(1.14); C334(0.72); C341(1.03)  LDD0805  [25]
 LDCM0489  CL94 HCT 116 C14(1.30); C334(0.81); C341(1.01)  LDD0806  [25]
 LDCM0490  CL95 HCT 116 C14(1.67); C334(0.70); C341(0.94)  LDD0807  [25]
 LDCM0491  CL96 HCT 116 C14(1.45); C334(0.69); C341(0.93)  LDD0808  [25]
 LDCM0492  CL97 HCT 116 C14(1.20); C334(0.78); C341(1.03)  LDD0809  [25]
 LDCM0493  CL98 HCT 116 C14(1.53); C334(0.88); C341(1.05)  LDD0810  [25]
 LDCM0494  CL99 HCT 116 C14(1.22); C334(0.84); C341(1.02)  LDD0811  [25]
 LDCM0634  CY-0357 Hep-G2 C341(1.00); C14(0.76)  LDD2228  [13]
 LDCM0495  E2913 HEK-293T C14(1.13); C341(0.96); C334(0.98)  LDD1698  [26]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C14(5.01)  LDD1702  [27]
 LDCM0175  Ethacrynic acid HeLa N.A.  LDD0440  [5]
 LDCM0625  F8 Ramos C341(1.82); C334(0.78)  LDD2187  [28]
 LDCM0572  Fragment10 Ramos C341(2.94); C334(0.87)  LDD2189  [28]
 LDCM0573  Fragment11 Ramos C341(0.05); C334(1.06); C14(0.82)  LDD2190  [28]
 LDCM0574  Fragment12 Ramos C341(20.00); C334(1.24)  LDD2191  [28]
 LDCM0575  Fragment13 Ramos C341(1.07); C334(0.88)  LDD2192  [28]
 LDCM0576  Fragment14 Ramos C341(4.17); C334(2.21); C14(0.62)  LDD2193  [28]
 LDCM0579  Fragment20 Ramos C334(1.41)  LDD2194  [28]
 LDCM0580  Fragment21 Ramos C341(1.28); C334(1.03)  LDD2195  [28]
 LDCM0582  Fragment23 Ramos C341(7.49)  LDD2196  [28]
 LDCM0578  Fragment27 Ramos C341(0.76); C334(1.37)  LDD2197  [28]
 LDCM0586  Fragment28 Ramos C341(0.75); C334(1.61); C14(0.75)  LDD2198  [28]
 LDCM0588  Fragment30 Ramos C341(1.42); C334(0.93)  LDD2199  [28]
 LDCM0589  Fragment31 Ramos C341(1.63); C334(1.86)  LDD2200  [28]
 LDCM0590  Fragment32 Ramos C341(7.69); C334(1.11)  LDD2201  [28]
 LDCM0468  Fragment33 HCT 116 C334(0.91); C341(1.18)  LDD0785  [25]
 LDCM0596  Fragment38 Ramos C341(1.58); C334(0.88)  LDD2203  [28]
 LDCM0566  Fragment4 Ramos C334(2.15)  LDD2184  [28]
 LDCM0427  Fragment51 HCT 116 C14(2.29); C334(0.93); C341(0.79)  LDD0744  [25]
 LDCM0610  Fragment52 Ramos C341(1.59); C334(0.87)  LDD2204  [28]
 LDCM0614  Fragment56 Ramos C341(1.41); C334(0.63)  LDD2205  [28]
 LDCM0569  Fragment7 Ramos C341(4.98); C334(1.12)  LDD2186  [28]
 LDCM0571  Fragment9 Ramos C334(2.50)  LDD2188  [28]
 LDCM0015  HNE MDA-MB-231 C334(0.82)  LDD0346  [28]
 LDCM0107  IAA HeLa H290(0.00); H26(0.00); H178(0.00); C334(0.00)  LDD0221  [18]
 LDCM0022  KB02 HEK-293T C14(1.09); C334(0.98); C341(0.88)  LDD1492  [26]
 LDCM0023  KB03 Jurkat C14(77.68)  LDD0209  [6]
 LDCM0024  KB05 COLO792 C334(2.36)  LDD3310  [29]
 LDCM0109  NEM HeLa H290(0.00); H178(0.00)  LDD0223  [18]
 LDCM0499  Nucleophilic fragment 12b MDA-MB-231 C14(0.63)  LDD2092  [27]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C14(0.69)  LDD2098  [27]
 LDCM0627  NUDT7-COV-1 HEK-293T C341(1.07); C334(0.88)  LDD2206  [30]
 LDCM0628  OTUB2-COV-1 HEK-293T C341(1.08); C334(0.74)  LDD2207  [30]
 LDCM0131  RA190 MM1.R C14(1.08)  LDD0304  [31]
 LDCM0021  THZ1 HCT 116 C341(1.09)  LDD2173  [25]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 34 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pachytene checkpoint protein 2 homolog (TRIP13) AAA ATPase family Q15645
DNA-directed RNA polymerases I, II, and III subunit RPABC5 (POLR2L) Archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family P62875
Catechol O-methyltransferase (COMT) Cation-dependent O-methyltransferase family P21964
Protein-lysine N-methyltransferase EEF2KMT (EEF2KMT) EEF2KMT family Q96G04
Glutamine--tRNA ligase (QARS1) Class-I aminoacyl-tRNA synthetase family P47897
Kynurenine--oxoglutarate transaminase 1 (KYAT1) Class-I pyridoxal-phosphate-dependent aminotransferase family Q16773
Putative hydrolase DDAH2 (DDAH2) DDAH family O95865
Disco-interacting protein 2 homolog A (DIP2A) DIP2 family Q14689
NADH-cytochrome b5 reductase 2 (CYB5R2) Flavoprotein pyridine nucleotide cytochrome reductase family Q6BCY4
Galactose-1-phosphate uridylyltransferase (GALT) Galactose-1-phosphate uridylyltransferase type 1 family P07902
Glycerate kinase (GLYCTK) Glycerate kinase type-2 family Q8IVS8
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Haloacid dehalogenase-like hydrolase domain-containing protein 3 (HDHD3) HAD-like hydrolase superfamily Q9BSH5
Lysyl oxidase homolog 4 (LOXL4) Lysyl oxidase family Q96JB6
Dihydropyrimidinase-related protein 4 (DPYSL4) Hydantoinase/dihydropyrimidinase family O14531
N-acetylglucosamine-6-phosphate deacetylase (AMDHD2) NagA family Q9Y303
Nucleoside diphosphate kinase, mitochondrial (NME4) NDK family O00746
Protein N-terminal glutamine amidohydrolase (NTAQ1) NTAQ1 family Q96HA8
E3 ubiquitin-protein ligase pellino homolog 1 (PELI1) Pellino family Q96FA3
Tubulointerstitial nephritis antigen-like (TINAGL1) Peptidase C1 family Q9GZM7
STAM-binding protein (STAMBP) Peptidase M67C family O95630
Phenazine biosynthesis-like domain-containing protein (PBLD) PhzF family P30039
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform (PPP2CA) PPP phosphatase family P67775
5'-AMP-activated protein kinase catalytic subunit alpha-2 (PRKAA2) CAMK Ser/Thr protein kinase family P54646
E3 ubiquitin-protein ligase parkin (PRKN) RBR family, Parkin subfamily O60260
Methanethiol oxidase (SELENBP1) Selenium-binding protein family Q13228
ADP-ribosylation factor-like protein 11 (ARL11) Arf family Q969Q4
Arylsulfatase A (ARSA) Sulfatase family P15289
Terminal nucleotidyltransferase 5B (TENT5B) TENT family Q96A09
Sterol carrier protein 2 (SCP2) Thiolase family P22307
Metallophosphoesterase MPPED2 (MPPED2) UPF0046 family Q15777
E3 ubiquitin-protein ligase LNX (LNX1) . Q8TBB1
E3 ubiquitin-protein ligase RNF4 (RNF4) . P78317
Ester hydrolase C11orf54 (C11orf54) . Q9H0W9
Transporter and channel
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Vitamin D3 receptor (VDR) Nuclear hormone receptor family P11473
Phospholipid scramblase 3 (PLSCR3) Phospholipid scramblase family Q9NRY6
Phospholipid scramblase 4 (PLSCR4) Phospholipid scramblase family Q9NRQ2
Syntenin-1 (SDCBP) . O00560
Transcription factor
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Rhox homeobox family member 2 (RHOXF2) Paired-like homeobox family Q9BQY4
Homeobox protein VENTX (VENTX) . O95231
Paired box protein Pax-9 (PAX9) . P55771
Immunoglobulin
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sialic acid-binding Ig-like lectin 5 (SIGLEC5) SIGLEC (sialic acid binding Ig-like lectin) family O15389
Semaphorin-4G (SEMA4G) Semaphorin family Q9NTN9
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Interleukin-2 receptor subunit beta (IL2RB) Type I cytokine receptor family P14784
Other
Click To Hide/Show 24 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Beta-crystallin A2 (CRYBA2) Beta/gamma-crystallin family P53672
Fibulin-5 (FBLN5) Fibulin family Q9UBX5
Trinucleotide repeat-containing gene 6A protein (TNRC6A) GW182 family Q8NDV7
Protein INCA1 (INCA1) INCA family Q0VD86
Keratin-associated protein 12-1 (KRTAP12-1) KRTAP type 12 family P59990
Keratin-associated protein 12-2 (KRTAP12-2) KRTAP type 12 family P59991
Keratin-associated protein 12-4 (KRTAP12-4) KRTAP type 12 family P60329
Keratin-associated protein 6-1 (KRTAP6-1) KRTAP type 6 family Q3LI64
Keratin-associated protein 6-2 (KRTAP6-2) KRTAP type 6 family Q3LI66
MAD2L1-binding protein (MAD2L1BP) MAD2L1BP family Q15013
Keratin-associated protein 26-1 (KRTAP26-1) PMG family Q6PEX3
Translationally-controlled tumor protein (TPT1) TCTP family P13693
UPF0462 protein C4orf33 (C4orf33) UPF0462 family Q8N1A6
CAP-Gly domain-containing linker protein 4 (CLIP4) . Q8N3C7
CDAN1-interacting nuclease 1 (CDIN1) . Q9Y2V0
Leucine-rich repeat protein 1 (LRR1) . Q96L50
LIM and SH3 domain protein 1 (LASP1) . Q14847
Meiosis 1 arrest protein (M1AP) . Q8TC57
MORN repeat-containing protein 3 (MORN3) . Q6PF18
MTOR-associated protein MEAK7 (MEAK7) . Q6P9B6
Myeloma-overexpressed gene protein (MYEOV) . Q96EZ4
Proline-rich protein 13 (PRR13) . Q9NZ81
Protein SPMIP9 (SPMIP9) . Q96LM6
SPRY domain-containing protein 7 (SPRYD7) . Q5W111

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
5 Chemoproteomic Profiling Reveals Ethacrynic Acid Targets Adenine Nucleotide Translocases to Impair Mitochondrial Function. Mol Pharm. 2018 Jun 4;15(6):2413-2422. doi: 10.1021/acs.molpharmaceut.8b00250. Epub 2018 May 15.
6 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
7 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
10 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
11 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22.
Mass spectrometry data entry: PXD033004
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
20 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
21 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
22 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
23 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
24 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
25 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402
27 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
28 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578
29 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
30 Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
31 Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.