Details of the Target

General Information of Target

Target ID LDTP09390
Target Name Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1)
Gene Name PNPT1
Gene ID 87178
Synonyms
PNPASE; Polyribonucleotide nucleotidyltransferase 1, mitochondrial; EC 2.7.7.8; 3'-5' RNA exonuclease OLD35; PNPase old-35; Polynucleotide phosphorylase 1; PNPase 1; Polynucleotide phosphorylase-like protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAACRYCCSCLRLRPLSDGPFLLPRRDRALTQLQVRALWSSAGSRAVAVDLGNRKLEISS
GKLARFADGSAVVQSGDTAVMVTAVSKTKPSPSQFMPLVVDYRQKAAAAGRIPTNYLRRE
IGTSDKEILTSRIIDRSIRPLFPAGYFYDTQVLCNLLAVDGVNEPDVLAINGASVALSLS
DIPWNGPVGAVRIGIIDGEYVVNPTRKEMSSSTLNLVVAGAPKSQIVMLEASAENILQQD
FCHAIKVGVKYTQQIIQGIQQLVKETGVTKRTPQKLFTPSPEIVKYTHKLAMERLYAVFT
DYEHDKVSRDEAVNKIRLDTEEQLKEKFPEADPYEIIESFNVVAKEVFRSIVLNEYKRCD
GRDLTSLRNVSCEVDMFKTLHGSALFQRGQTQVLCTVTFDSLESGIKSDQVITAINGIKD
KNFMLHYEFPPYATNEIGKVTGLNRRELGHGALAEKALYPVIPRDFPFTIRVTSEVLESN
GSSSMASACGGSLALMDSGVPISSAVAGVAIGLVTKTDPEKGEIEDYRLLTDILGIEDYN
GDMDFKIAGTNKGITALQADIKLPGIPIKIVMEAIQQASVAKKEILQIMNKTISKPRASR
KENGPVVETVQVPLSKRAKFVGPGGYNLKKLQAETGVTISQVDEETFSVFAPTPSAMHEA
RDFITEICKDDQEQQLEFGAVYTATITEIRDTGVMVKLYPNMTAVLLHNTQLDQRKIKHP
TALGLEVGQEIQVKYFGRDPADGRMRLSRKVLQSPATTVVRTLNDRSSIVMGEPISQSSS
NSQ
Target Bioclass
Enzyme
Family
Polyribonucleotide nucleotidyltransferase family
Subcellular location
Cytoplasm
Function
RNA-binding protein implicated in numerous RNA metabolic processes. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'-to-5' direction. Mitochondrial intermembrane factor with RNA-processing exoribonulease activity. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules. Required for correct processing and polyadenylation of mitochondrial mRNAs. Plays a role as a cytoplasmic RNA import factor that mediates the translocation of small RNA components, like the 5S RNA, the RNA subunit of ribonuclease P and the mitochondrial RNA-processing (MRP) RNA, into the mitochondrial matrix. Plays a role in mitochondrial morphogenesis and respiration; regulates the expression of the electron transport chain (ETC) components at the mRNA and protein levels. In the cytoplasm, shows a 3'-to-5' exoribonuclease mediating mRNA degradation activity; degrades c-myc mRNA upon treatment with IFNB1/IFN-beta, resulting in a growth arrest in melanoma cells. Regulates the stability of specific mature miRNAs in melanoma cells; specifically and selectively degrades miR-221, preferentially. Also plays a role in RNA cell surveillance by cleaning up oxidized RNAs. Binds to the RNA subunit of ribonuclease P, MRP RNA and miR-221 microRNA.
Uniprot ID
Q8TCS8
Ensemble ID
ENST00000415374.5
HGNC ID
HGNC:23166

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 26 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
N1
 Probe Info  		100.00  LDD0242  [1]
TH211
 Probe Info  		Y626(20.00); Y539(17.24)  LDD0260  [2]
YN-1
 Probe Info  		100.00  LDD0444  [3]
ONAyne
 Probe Info  		N.A.  LDD0273  [4]
IPM
 Probe Info  		C668(0.00); C242(0.00); C372(0.00)  LDD0241  [5]
Probe 1
 Probe Info  		Y116(17.36); Y356(19.60); Y626(28.20)  LDD3495  [6]
m-APA
 Probe Info  		10.33  LDD0403  [7]
BTD
 Probe Info  		C372(0.45)  LDD2100  [8]
DBIA
 Probe Info  		C668(1.21)  LDD0080  [9]
5E-2FA
 Probe Info  		N.A.  LDD2235  [10]
ATP probe
 Probe Info  		K750(0.00); K456(0.00); K629(0.00); K630(0.00)  LDD0199  [11]
4-Iodoacetamidophenylacetylene
 Probe Info  		C395(0.00); C372(0.00); C242(0.00)  LDD0038  [12]
IA-alkyne
 Probe Info  		C372(0.00); C242(0.00); C395(0.00)  LDD0036  [12]
Lodoacetamide azide
 Probe Info  		C372(0.00); C242(0.00); C395(0.00)  LDD0037  [12]
NHS
 Probe Info  		N.A.  LDD0010  [13]
SF
 Probe Info  		Y116(0.00); Y251(0.00); K629(0.00)  LDD0028  [14]
STPyne
 Probe Info  		K582(0.00); K750(0.00)  LDD0009  [13]
TFBX
 Probe Info  		C359(0.00); C668(0.00)  LDD0148  [15]
Ox-W18
 Probe Info  		N.A.  LDD2175  [16]
1c-yne
 Probe Info  		K616(0.00); K569(0.00)  LDD0228  [17]
Acrolein
 Probe Info  		N.A.  LDD0217  [18]
Crotonaldehyde
 Probe Info  		N.A.  LDD0219  [18]
Methacrolein
 Probe Info  		N.A.  LDD0218  [18]
W1
 Probe Info  		N.A.  LDD0236  [5]
NAIA_5
 Probe Info  		C372(0.00); C242(0.00)  LDD2223  [19]
HHS-465
 Probe Info  		K546(0.00); Y539(0.00)  LDD2240  [20]
PAL-AfBPP Probe
Click To Hide/Show 7 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C210
 Probe Info  		39.40  LDD1884  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [22]
FFF probe3
 Probe Info  		20.00  LDD0465  [22]
JN0003
 Probe Info  		5.02  LDD0469  [22]
STS-1
 Probe Info  		N.A.  LDD0136  [23]
STS-2
 Probe Info  		N.A.  LDD0138  [23]
VE-P
 Probe Info  		N.A.  LDD0396  [24]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0548  1-(4-(Benzo[d][1,3]dioxol-5-ylmethyl)piperazin-1-yl)-2-nitroethan-1-one MDA-MB-231 C372(1.34)  LDD2142  [8]
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C372(1.06)  LDD2112  [8]
 LDCM0563  Abegg_cp(+)-11 HeLa C359(2.20)  LDD0314  [15]
 LDCM0214  AC1 HCT 116 C668(1.01)  LDD0531  [9]
 LDCM0215  AC10 HCT 116 C668(0.98)  LDD0532  [9]
 LDCM0226  AC11 HCT 116 C668(1.01)  LDD0543  [9]
 LDCM0230  AC113 HCT 116 C668(1.07)  LDD0547  [9]
 LDCM0231  AC114 HCT 116 C668(1.10)  LDD0548  [9]
 LDCM0232  AC115 HCT 116 C668(1.21)  LDD0549  [9]
 LDCM0233  AC116 HCT 116 C668(1.18)  LDD0550  [9]
 LDCM0234  AC117 HCT 116 C668(1.17)  LDD0551  [9]
 LDCM0235  AC118 HCT 116 C668(1.08)  LDD0552  [9]
 LDCM0236  AC119 HCT 116 C668(1.25)  LDD0553  [9]
 LDCM0237  AC12 HCT 116 C668(0.98)  LDD0554  [9]
 LDCM0238  AC120 HCT 116 C668(0.95)  LDD0555  [9]
 LDCM0239  AC121 HCT 116 C668(0.95)  LDD0556  [9]
 LDCM0240  AC122 HCT 116 C668(1.13)  LDD0557  [9]
 LDCM0241  AC123 HCT 116 C668(0.87)  LDD0558  [9]
 LDCM0242  AC124 HCT 116 C668(1.12)  LDD0559  [9]
 LDCM0243  AC125 HCT 116 C668(1.07)  LDD0560  [9]
 LDCM0244  AC126 HCT 116 C668(1.00)  LDD0561  [9]
 LDCM0245  AC127 HCT 116 C668(1.24)  LDD0562  [9]
 LDCM0246  AC128 HEK-293T C668(1.10)  LDD0844  [9]
 LDCM0247  AC129 HEK-293T C668(1.08)  LDD0845  [9]
 LDCM0249  AC130 HEK-293T C668(0.99)  LDD0847  [9]
 LDCM0250  AC131 HEK-293T C668(0.99)  LDD0848  [9]
 LDCM0251  AC132 HEK-293T C668(1.24)  LDD0849  [9]
 LDCM0252  AC133 HEK-293T C668(1.22)  LDD0850  [9]
 LDCM0253  AC134 HEK-293T C668(0.95)  LDD0851  [9]
 LDCM0254  AC135 HEK-293T C668(1.17)  LDD0852  [9]
 LDCM0255  AC136 HEK-293T C668(1.05)  LDD0853  [9]
 LDCM0256  AC137 HEK-293T C668(1.40)  LDD0854  [9]
 LDCM0257  AC138 HEK-293T C668(0.98)  LDD0855  [9]
 LDCM0258  AC139 HEK-293T C668(1.10)  LDD0856  [9]
 LDCM0259  AC14 HCT 116 C668(0.78)  LDD0576  [9]
 LDCM0260  AC140 HEK-293T C668(1.16)  LDD0858  [9]
 LDCM0261  AC141 HEK-293T C668(1.10)  LDD0859  [9]
 LDCM0262  AC142 HEK-293T C668(1.13)  LDD0860  [9]
 LDCM0263  AC143 HCT 116 C668(1.33)  LDD0580  [9]
 LDCM0264  AC144 HCT 116 C668(0.87)  LDD0581  [9]
 LDCM0265  AC145 HCT 116 C668(0.92)  LDD0582  [9]
 LDCM0266  AC146 HCT 116 C668(1.21)  LDD0583  [9]
 LDCM0267  AC147 HCT 116 C668(0.98)  LDD0584  [9]
 LDCM0268  AC148 HCT 116 C668(1.77)  LDD0585  [9]
 LDCM0269  AC149 HCT 116 C668(1.93)  LDD0586  [9]
 LDCM0270  AC15 HCT 116 C668(0.93)  LDD0587  [9]
 LDCM0271  AC150 HCT 116 C668(1.20)  LDD0588  [9]
 LDCM0272  AC151 HCT 116 C668(1.18)  LDD0589  [9]
 LDCM0273  AC152 HCT 116 C668(1.17)  LDD0590  [9]
 LDCM0274  AC153 HCT 116 C668(1.57)  LDD0591  [9]
 LDCM0621  AC154 HCT 116 C668(1.06)  LDD2158  [9]
 LDCM0622  AC155 HCT 116 C668(1.25)  LDD2159  [9]
 LDCM0623  AC156 HCT 116 C668(1.11)  LDD2160  [9]
 LDCM0624  AC157 HCT 116 C668(1.14)  LDD2161  [9]
 LDCM0276  AC17 HEK-293T C668(1.18)  LDD0874  [9]
 LDCM0277  AC18 HEK-293T C668(1.27)  LDD0875  [9]
 LDCM0278  AC19 HEK-293T C668(1.17)  LDD0876  [9]
 LDCM0279  AC2 HCT 116 C668(1.23)  LDD0596  [9]
 LDCM0280  AC20 HEK-293T C668(1.35)  LDD0878  [9]
 LDCM0281  AC21 HEK-293T C668(1.32)  LDD0879  [9]
 LDCM0282  AC22 HEK-293T C668(1.32)  LDD0880  [9]
 LDCM0283  AC23 HEK-293T C668(1.42)  LDD0881  [9]
 LDCM0284  AC24 HEK-293T C668(1.08)  LDD0882  [9]
 LDCM0285  AC25 HCT 116 C668(0.92)  LDD0602  [9]
 LDCM0286  AC26 HCT 116 C668(1.00)  LDD0603  [9]
 LDCM0287  AC27 HCT 116 C668(0.93)  LDD0604  [9]
 LDCM0288  AC28 HCT 116 C668(0.94)  LDD0605  [9]
 LDCM0289  AC29 HCT 116 C668(1.08)  LDD0606  [9]
 LDCM0290  AC3 HCT 116 C668(1.22)  LDD0607  [9]
 LDCM0291  AC30 HCT 116 C668(0.95)  LDD0608  [9]
 LDCM0292  AC31 HCT 116 C668(1.00)  LDD0609  [9]
 LDCM0293  AC32 HCT 116 C668(0.92)  LDD0610  [9]
 LDCM0294  AC33 HCT 116 C668(0.95)  LDD0611  [9]
 LDCM0295  AC34 HCT 116 C668(1.02)  LDD0612  [9]
 LDCM0296  AC35 HCT 116 C668(1.36)  LDD0613  [9]
 LDCM0297  AC36 HCT 116 C668(1.06)  LDD0614  [9]
 LDCM0298  AC37 HCT 116 C668(1.02)  LDD0615  [9]
 LDCM0299  AC38 HCT 116 C668(1.06)  LDD0616  [9]
 LDCM0300  AC39 HCT 116 C668(1.16)  LDD0617  [9]
 LDCM0301  AC4 HCT 116 C668(1.10)  LDD0618  [9]
 LDCM0302  AC40 HCT 116 C668(0.95)  LDD0619  [9]
 LDCM0303  AC41 HCT 116 C668(1.04)  LDD0620  [9]
 LDCM0304  AC42 HCT 116 C668(0.98)  LDD0621  [9]
 LDCM0305  AC43 HCT 116 C668(0.74)  LDD0622  [9]
 LDCM0306  AC44 HCT 116 C668(1.06)  LDD0623  [9]
 LDCM0307  AC45 HCT 116 C668(0.97)  LDD0624  [9]
 LDCM0308  AC46 HCT 116 C668(1.01)  LDD0625  [9]
 LDCM0309  AC47 HCT 116 C668(0.92)  LDD0626  [9]
 LDCM0310  AC48 HCT 116 C668(0.88)  LDD0627  [9]
 LDCM0311  AC49 HCT 116 C668(1.02)  LDD0628  [9]
 LDCM0312  AC5 HCT 116 C668(1.20)  LDD0629  [9]
 LDCM0313  AC50 HCT 116 C668(0.88)  LDD0630  [9]
 LDCM0314  AC51 HCT 116 C668(0.83)  LDD0631  [9]
 LDCM0315  AC52 HCT 116 C668(0.88)  LDD0632  [9]
 LDCM0316  AC53 HCT 116 C668(0.86)  LDD0633  [9]
 LDCM0317  AC54 HCT 116 C668(0.78)  LDD0634  [9]
 LDCM0318  AC55 HCT 116 C668(1.18)  LDD0635  [9]
 LDCM0319  AC56 HCT 116 C668(0.84)  LDD0636  [9]
 LDCM0320  AC57 HCT 116 C668(0.90)  LDD0637  [9]
 LDCM0321  AC58 HCT 116 C668(0.77)  LDD0638  [9]
 LDCM0322  AC59 HCT 116 C668(0.85)  LDD0639  [9]
 LDCM0323  AC6 HCT 116 C668(0.95)  LDD0640  [9]
 LDCM0324  AC60 HCT 116 C668(0.97)  LDD0641  [9]
 LDCM0325  AC61 HCT 116 C668(0.94)  LDD0642  [9]
 LDCM0326  AC62 HCT 116 C668(1.06)  LDD0643  [9]
 LDCM0327  AC63 HCT 116 C668(0.82)  LDD0644  [9]
 LDCM0328  AC64 HCT 116 C668(0.78)  LDD0645  [9]
 LDCM0329  AC65 HCT 116 C668(0.91)  LDD0646  [9]
 LDCM0330  AC66 HCT 116 C668(1.00)  LDD0647  [9]
 LDCM0331  AC67 HCT 116 C668(1.00)  LDD0648  [9]
 LDCM0332  AC68 HCT 116 C668(0.87)  LDD0649  [9]
 LDCM0333  AC69 HCT 116 C668(0.84)  LDD0650  [9]
 LDCM0334  AC7 HCT 116 C668(0.91)  LDD0651  [9]
 LDCM0335  AC70 HCT 116 C668(0.98)  LDD0652  [9]
 LDCM0336  AC71 HCT 116 C668(0.84)  LDD0653  [9]
 LDCM0337  AC72 HCT 116 C668(0.93)  LDD0654  [9]
 LDCM0338  AC73 HCT 116 C668(1.00)  LDD0655  [9]
 LDCM0339  AC74 HCT 116 C668(0.86)  LDD0656  [9]
 LDCM0340  AC75 HCT 116 C668(1.05)  LDD0657  [9]
 LDCM0341  AC76 HCT 116 C668(0.87)  LDD0658  [9]
 LDCM0342  AC77 HCT 116 C668(0.90)  LDD0659  [9]
 LDCM0343  AC78 HCT 116 C668(0.99)  LDD0660  [9]
 LDCM0344  AC79 HCT 116 C668(0.97)  LDD0661  [9]
 LDCM0345  AC8 HCT 116 C668(1.04)  LDD0662  [9]
 LDCM0346  AC80 HCT 116 C668(0.95)  LDD0663  [9]
 LDCM0347  AC81 HCT 116 C668(0.95)  LDD0664  [9]
 LDCM0348  AC82 HCT 116 C668(1.04)  LDD0665  [9]
 LDCM0349  AC83 HCT 116 C668(1.00)  LDD0666  [9]
 LDCM0350  AC84 HCT 116 C668(0.94)  LDD0667  [9]
 LDCM0351  AC85 HCT 116 C668(1.07)  LDD0668  [9]
 LDCM0352  AC86 HCT 116 C668(0.95)  LDD0669  [9]
 LDCM0353  AC87 HCT 116 C668(0.95)  LDD0670  [9]
 LDCM0354  AC88 HCT 116 C668(0.91)  LDD0671  [9]
 LDCM0355  AC89 HCT 116 C668(1.06)  LDD0672  [9]
 LDCM0357  AC90 HCT 116 C668(1.16)  LDD0674  [9]
 LDCM0358  AC91 HCT 116 C668(0.96)  LDD0675  [9]
 LDCM0359  AC92 HCT 116 C668(1.22)  LDD0676  [9]
 LDCM0360  AC93 HCT 116 C668(0.97)  LDD0677  [9]
 LDCM0361  AC94 HCT 116 C668(1.11)  LDD0678  [9]
 LDCM0362  AC95 HCT 116 C668(0.91)  LDD0679  [9]
 LDCM0363  AC96 HCT 116 C668(0.98)  LDD0680  [9]
 LDCM0364  AC97 HCT 116 C668(1.06)  LDD0681  [9]
 LDCM0248  AKOS034007472 HCT 116 C668(1.00)  LDD0565  [9]
 LDCM0356  AKOS034007680 HCT 116 C668(1.07)  LDD0673  [9]
 LDCM0275  AKOS034007705 HCT 116 C668(0.83)  LDD0592  [9]
 LDCM0156  Aniline NCI-H1299 10.33  LDD0403  [7]
 LDCM0020  ARS-1620 HCC44 C668(1.09)  LDD2171  [9]
 LDCM0102  BDHI 8 Jurkat C668(5.31)  LDD0204  [25]
 LDCM0108  Chloroacetamide HeLa C372(0.00); C395(0.00); C668(0.00)  LDD0222  [18]
 LDCM0367  CL1 HCT 116 C668(0.98)  LDD0684  [9]
 LDCM0368  CL10 HCT 116 C668(1.21)  LDD0685  [9]
 LDCM0369  CL100 HCT 116 C668(1.02)  LDD0686  [9]
 LDCM0370  CL101 HCT 116 C668(0.80)  LDD0687  [9]
 LDCM0371  CL102 HCT 116 C668(0.66)  LDD0688  [9]
 LDCM0372  CL103 HCT 116 C668(0.80)  LDD0689  [9]
 LDCM0373  CL104 HCT 116 C668(0.82)  LDD0690  [9]
 LDCM0374  CL105 HEK-293T C668(1.31)  LDD0972  [9]
 LDCM0375  CL106 HEK-293T C668(1.44)  LDD0973  [9]
 LDCM0376  CL107 HEK-293T C668(1.13)  LDD0974  [9]
 LDCM0377  CL108 HEK-293T C668(1.23)  LDD0975  [9]
 LDCM0378  CL109 HEK-293T C668(1.53)  LDD0976  [9]
 LDCM0379  CL11 HCT 116 C668(1.14)  LDD0696  [9]
 LDCM0380  CL110 HEK-293T C668(1.38)  LDD0978  [9]
 LDCM0381  CL111 HEK-293T C668(1.65)  LDD0979  [9]
 LDCM0382  CL112 HCT 116 C668(0.79)  LDD0699  [9]
 LDCM0383  CL113 HCT 116 C668(0.90)  LDD0700  [9]
 LDCM0384  CL114 HCT 116 C668(0.93)  LDD0701  [9]
 LDCM0385  CL115 HCT 116 C668(0.87)  LDD0702  [9]
 LDCM0386  CL116 HCT 116 C668(1.14)  LDD0703  [9]
 LDCM0387  CL117 HCT 116 C668(1.14)  LDD0704  [9]
 LDCM0388  CL118 HCT 116 C668(1.33)  LDD0705  [9]
 LDCM0389  CL119 HCT 116 C668(0.99)  LDD0706  [9]
 LDCM0390  CL12 HCT 116 C668(1.35)  LDD0707  [9]
 LDCM0391  CL120 HCT 116 C668(0.84)  LDD0708  [9]
 LDCM0392  CL121 HCT 116 C668(1.03)  LDD0709  [9]
 LDCM0393  CL122 HCT 116 C668(0.94)  LDD0710  [9]
 LDCM0394  CL123 HCT 116 C668(0.79)  LDD0711  [9]
 LDCM0395  CL124 HCT 116 C668(1.01)  LDD0712  [9]
 LDCM0396  CL125 HCT 116 C668(0.96)  LDD0713  [9]
 LDCM0397  CL126 HCT 116 C668(0.86)  LDD0714  [9]
 LDCM0398  CL127 HCT 116 C668(1.01)  LDD0715  [9]
 LDCM0399  CL128 HCT 116 C668(0.82)  LDD0716  [9]
 LDCM0400  CL13 HCT 116 C668(1.15)  LDD0717  [9]
 LDCM0401  CL14 HCT 116 C668(1.04)  LDD0718  [9]
 LDCM0402  CL15 HCT 116 C668(1.11)  LDD0719  [9]
 LDCM0403  CL16 HCT 116 C668(1.04)  LDD0720  [9]
 LDCM0404  CL17 HCT 116 C668(1.09)  LDD0721  [9]
 LDCM0405  CL18 HCT 116 C668(1.27)  LDD0722  [9]
 LDCM0406  CL19 HCT 116 C668(1.21)  LDD0723  [9]
 LDCM0407  CL2 HCT 116 C668(0.97)  LDD0724  [9]
 LDCM0408  CL20 HCT 116 C668(1.25)  LDD0725  [9]
 LDCM0409  CL21 HCT 116 C668(1.44)  LDD0726  [9]
 LDCM0410  CL22 HCT 116 C668(1.62)  LDD0727  [9]
 LDCM0411  CL23 HCT 116 C668(1.08)  LDD0728  [9]
 LDCM0412  CL24 HCT 116 C668(1.31)  LDD0729  [9]
 LDCM0413  CL25 HCT 116 C668(1.28)  LDD0730  [9]
 LDCM0414  CL26 HCT 116 C668(1.14)  LDD0731  [9]
 LDCM0415  CL27 HCT 116 C668(1.07)  LDD0732  [9]
 LDCM0416  CL28 HCT 116 C668(1.21)  LDD0733  [9]
 LDCM0417  CL29 HCT 116 C668(1.26)  LDD0734  [9]
 LDCM0418  CL3 HCT 116 C668(0.97)  LDD0735  [9]
 LDCM0419  CL30 HCT 116 C668(1.04)  LDD0736  [9]
 LDCM0420  CL31 HCT 116 C668(0.88)  LDD0737  [9]
 LDCM0421  CL32 HCT 116 C668(0.96)  LDD0738  [9]
 LDCM0422  CL33 HCT 116 C668(0.89)  LDD0739  [9]
 LDCM0423  CL34 HCT 116 C668(1.06)  LDD0740  [9]
 LDCM0424  CL35 HCT 116 C668(0.98)  LDD0741  [9]
 LDCM0425  CL36 HCT 116 C668(0.96)  LDD0742  [9]
 LDCM0426  CL37 HCT 116 C668(0.87)  LDD0743  [9]
 LDCM0428  CL39 HCT 116 C668(0.86)  LDD0745  [9]
 LDCM0429  CL4 HCT 116 C668(1.05)  LDD0746  [9]
 LDCM0430  CL40 HCT 116 C668(0.81)  LDD0747  [9]
 LDCM0431  CL41 HCT 116 C668(0.85)  LDD0748  [9]
 LDCM0432  CL42 HCT 116 C668(0.81)  LDD0749  [9]
 LDCM0433  CL43 HCT 116 C668(0.83)  LDD0750  [9]
 LDCM0434  CL44 HCT 116 C668(0.95)  LDD0751  [9]
 LDCM0435  CL45 HCT 116 C668(1.18)  LDD0752  [9]
 LDCM0436  CL46 HCT 116 C668(1.16)  LDD0753  [9]
 LDCM0437  CL47 HCT 116 C668(1.23)  LDD0754  [9]
 LDCM0438  CL48 HCT 116 C668(1.09)  LDD0755  [9]
 LDCM0439  CL49 HCT 116 C668(0.97)  LDD0756  [9]
 LDCM0440  CL5 HCT 116 C668(1.10)  LDD0757  [9]
 LDCM0441  CL50 HCT 116 C668(0.97)  LDD0758  [9]
 LDCM0442  CL51 HCT 116 C668(1.02)  LDD0759  [9]
 LDCM0443  CL52 HCT 116 C668(1.12)  LDD0760  [9]
 LDCM0444  CL53 HCT 116 C668(1.10)  LDD0761  [9]
 LDCM0445  CL54 HCT 116 C668(1.00)  LDD0762  [9]
 LDCM0446  CL55 HCT 116 C668(1.11)  LDD0763  [9]
 LDCM0447  CL56 HCT 116 C668(1.05)  LDD0764  [9]
 LDCM0448  CL57 HCT 116 C668(1.00)  LDD0765  [9]
 LDCM0449  CL58 HCT 116 C668(1.21)  LDD0766  [9]
 LDCM0450  CL59 HCT 116 C668(1.11)  LDD0767  [9]
 LDCM0451  CL6 HCT 116 C668(1.09)  LDD0768  [9]
 LDCM0452  CL60 HCT 116 C668(1.18)  LDD0769  [9]
 LDCM0453  CL61 HCT 116 C668(1.01)  LDD0770  [9]
 LDCM0454  CL62 HCT 116 C668(0.99)  LDD0771  [9]
 LDCM0455  CL63 HCT 116 C668(0.88)  LDD0772  [9]
 LDCM0456  CL64 HCT 116 C668(0.99)  LDD0773  [9]
 LDCM0457  CL65 HCT 116 C668(0.88)  LDD0774  [9]
 LDCM0458  CL66 HCT 116 C668(1.00)  LDD0775  [9]
 LDCM0459  CL67 HCT 116 C668(0.87)  LDD0776  [9]
 LDCM0460  CL68 HCT 116 C668(0.80)  LDD0777  [9]
 LDCM0461  CL69 HCT 116 C668(0.80)  LDD0778  [9]
 LDCM0462  CL7 HCT 116 C668(1.21)  LDD0779  [9]
 LDCM0463  CL70 HCT 116 C668(1.00)  LDD0780  [9]
 LDCM0464  CL71 HCT 116 C668(0.83)  LDD0781  [9]
 LDCM0465  CL72 HCT 116 C668(0.95)  LDD0782  [9]
 LDCM0466  CL73 HCT 116 C668(0.94)  LDD0783  [9]
 LDCM0467  CL74 HCT 116 C668(0.86)  LDD0784  [9]
 LDCM0469  CL76 HEK-293T C668(0.94)  LDD1067  [9]
 LDCM0470  CL77 HEK-293T C668(0.87)  LDD1068  [9]
 LDCM0471  CL78 HEK-293T C668(1.14)  LDD1069  [9]
 LDCM0472  CL79 HEK-293T C668(1.02)  LDD1070  [9]
 LDCM0473  CL8 HCT 116 C668(1.09)  LDD0790  [9]
 LDCM0474  CL80 HEK-293T C668(0.89)  LDD1072  [9]
 LDCM0475  CL81 HEK-293T C668(0.98)  LDD1073  [9]
 LDCM0476  CL82 HEK-293T C668(1.00)  LDD1074  [9]
 LDCM0477  CL83 HEK-293T C668(1.03)  LDD1075  [9]
 LDCM0478  CL84 HEK-293T C668(0.97)  LDD1076  [9]
 LDCM0479  CL85 HEK-293T C668(1.06)  LDD1077  [9]
 LDCM0480  CL86 HEK-293T C668(1.07)  LDD1078  [9]
 LDCM0481  CL87 HEK-293T C668(1.19)  LDD1079  [9]
 LDCM0482  CL88 HEK-293T C668(1.12)  LDD1080  [9]
 LDCM0483  CL89 HEK-293T C668(1.32)  LDD1081  [9]
 LDCM0484  CL9 HCT 116 C668(1.11)  LDD0801  [9]
 LDCM0485  CL90 HEK-293T C668(1.00)  LDD1083  [9]
 LDCM0486  CL91 HCT 116 C668(1.13)  LDD0803  [9]
 LDCM0487  CL92 HCT 116 C668(0.93)  LDD0804  [9]
 LDCM0488  CL93 HCT 116 C668(0.82)  LDD0805  [9]
 LDCM0489  CL94 HCT 116 C668(0.83)  LDD0806  [9]
 LDCM0490  CL95 HCT 116 C668(1.00)  LDD0807  [9]
 LDCM0491  CL96 HCT 116 C668(1.06)  LDD0808  [9]
 LDCM0492  CL97 HCT 116 C668(1.10)  LDD0809  [9]
 LDCM0493  CL98 HCT 116 C668(1.36)  LDD0810  [9]
 LDCM0494  CL99 HCT 116 C668(1.17)  LDD0811  [9]
 LDCM0495  E2913 HEK-293T C372(1.00); C668(1.00); C395(1.24); C242(0.97)  LDD1698  [26]
 LDCM0468  Fragment33 HCT 116 C668(0.91)  LDD0785  [9]
 LDCM0427  Fragment51 HCT 116 C668(0.70)  LDD0744  [9]
 LDCM0107  IAA HeLa C372(0.00); C668(0.00)  LDD0221  [18]
 LDCM0022  KB02 HCT 116 C668(1.21)  LDD0080  [9]
 LDCM0023  KB03 HCT 116 C668(1.02)  LDD0081  [9]
 LDCM0024  KB05 HCT 116 C668(1.44)  LDD0082  [9]
 LDCM0109  NEM HeLa N.A.  LDD0226  [18]
 LDCM0507  Nucleophilic fragment 16b MDA-MB-231 C372(0.45)  LDD2100  [8]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C372(0.51)  LDD2106  [8]
 LDCM0021  THZ1 HCT 116 C668(1.09)  LDD2173  [9]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
ATP-dependent RNA helicase SUPV3L1, mitochondrial (SUPV3L1) Helicase family Q8IYB8
Polyribonucleotide nucleotidyltransferase 1, mitochondrial (PNPT1) Polyribonucleotide nucleotidyltransferase family Q8TCS8

References

1 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors. J Med Chem. 2022 Aug 11;65(15):10408-10418. doi: 10.1021/acs.jmedchem.2c00272. Epub 2022 Jul 26.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
6 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
7 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
8 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
9 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
10 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
11 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
12 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
15 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
16 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
17 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
18 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
19 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
20 Global profiling identifies a stress-responsive tyrosine site on EDC3 regulating biomolecular condensate formation. Cell Chem Biol. 2022 Dec 15;29(12):1709-1720.e7. doi: 10.1016/j.chembiol.2022.11.008. Epub 2022 Dec 6.
Mass spectrometry data entry: PXD038010
21 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
22 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
23 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
24 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
25 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
26 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402