Details of the Target

General Information of Target

Target ID LDTP08081
Target Name Hepatoma-derived growth factor-related protein 2 (HDGFL2)
Gene Name HDGFL2
Gene ID 84717
Synonyms
HDGF2; HDGFRP2; HRP2; Hepatoma-derived growth factor-related protein 2; HDGF-related protein 2; HRP-2; Hepatoma-derived growth factor 2; HDGF-2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP
YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD
EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA
SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS
DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPERPPSS
SSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKERRRERADRG
EAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKKSAKKPQSSS
TEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKEPSVEEKLQKLHS
EIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYKANKDVMEKAA
EVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSA
PVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDSVREGPDLDRPGSDRQERERA
RGDSEALDEES
Target Bioclass
Other
Family
HDGF family
Subcellular location
Nucleus
Function
Acts as an epigenetic regulator of myogenesis in cooperation with DPF3a (isoform 2 of DPF3/BAF45C). Associates with the BAF complex via its interaction with DPF3a and HDGFL2-DPF3a activate myogenic genes by increasing chromatin accessibility through recruitment of SMARCA4/BRG1/BAF190A (ATPase subunit of the BAF complex) to myogenic gene promoters. Promotes the repair of DNA double-strand breaks (DSBs) through the homologous recombination pathway by facilitating the recruitment of the DNA endonuclease RBBP8 to the DSBs. Preferentially binds to chromatin regions marked by H3K9me3, H3K27me3 and H3K36me2. Involved in cellular growth control, through the regulation of cyclin D1 expression.
Uniprot ID
Q7Z4V5
Ensemble ID
ENST00000616600.5
HGNC ID
HGNC:14680
ChEMBL ID
CHEMBL4523364

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2780 SNV: p.Q345R DBIA    Probe Info 
MCC13 SNV: p.P394L DBIA    Probe Info 
MEWO SNV: p.P60S DBIA    Probe Info 
OVCAR5 SNV: p.G242E DBIA    Probe Info 
RCC10RGB SNV: p.R324M .
SNU5 Substitution: p.E191Ter DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 21 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K317(7.34); K487(7.32); K524(10.00); K554(9.92)  LDD0277  [1]
DBIA
 Probe Info  		C496(1.38)  LDD3311  [2]
BTD
 Probe Info  		C64(0.45)  LDD2104  [3]
HHS-475
 Probe Info  		Y18(0.42)  LDD0264  [4]
HHS-465
 Probe Info  		Y18(5.01); Y543(10.00)  LDD2237  [5]
ATP probe
 Probe Info  		K524(0.00); K525(0.00); K16(0.00); K483(0.00)  LDD0199  [6]
m-APA
 Probe Info  		N.A.  LDD2231  [7]
4-Iodoacetamidophenylacetylene
 Probe Info  		C631(0.00); C64(0.00); C496(0.00)  LDD0038  [8]
IA-alkyne
 Probe Info  		C631(0.00); C64(0.00); C496(0.00)  LDD0036  [8]
IPIAA_L
 Probe Info  		N.A.  LDD0031  [9]
Lodoacetamide azide
 Probe Info  		C631(0.00); C64(0.00); C496(0.00)  LDD0037  [8]
IPM
 Probe Info  		N.A.  LDD0005  [10]
NHS
 Probe Info  		K554(0.00); K415(0.00)  LDD0010  [10]
NPM
 Probe Info  		N.A.  LDD0016  [10]
OSF
 Probe Info  		N.A.  LDD0029  [11]
SF
 Probe Info  		K6(0.00); Y543(0.00)  LDD0028  [11]
TFBX
 Probe Info  		N.A.  LDD0148  [12]
VSF
 Probe Info  		N.A.  LDD0007  [10]
1c-yne
 Probe Info  		N.A.  LDD0228  [13]
Acrolein
 Probe Info  		N.A.  LDD0217  [14]
NAIA_5
 Probe Info  		C631(0.00); C496(0.00)  LDD2223  [15]
PAL-AfBPP Probe
Click To Hide/Show 13 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C106
 Probe Info  		19.29  LDD1793  [16]
C158
 Probe Info  		9.65  LDD1838  [16]
C236
 Probe Info  		5.35  LDD1909  [16]
C237
 Probe Info  		7.16  LDD1910  [16]
C238
 Probe Info  		19.29  LDD1911  [16]
C239
 Probe Info  		8.22  LDD1912  [16]
C240
 Probe Info  		10.78  LDD1913  [16]
C242
 Probe Info  		5.78  LDD1915  [16]
C290
 Probe Info  		11.55  LDD1960  [16]
C297
 Probe Info  		11.47  LDD1967  [16]
C320
 Probe Info  		34.30  LDD1986  [16]
C388
 Probe Info  		36.25  LDD2047  [16]
C420
 Probe Info  		16.34  LDD2075  [16]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0519  1-(6-methoxy-3,4-dihydroquinolin-1(2H)-yl)-2-nitroethan-1-one MDA-MB-231 C64(0.76)  LDD2112  [3]
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C64(0.65)  LDD2117  [3]
 LDCM0563  Abegg_cp(+)-11 HeLa C631(2.01)  LDD0314  [12]
 LDCM0214  AC1 HEK-293T C631(1.19); C496(0.85)  LDD1507  [17]
 LDCM0215  AC10 HEK-293T C631(1.11); C496(1.09)  LDD1508  [17]
 LDCM0226  AC11 HEK-293T C631(1.08); C496(1.18)  LDD1509  [17]
 LDCM0237  AC12 HEK-293T C631(1.07); C496(0.90)  LDD1510  [17]
 LDCM0259  AC14 HEK-293T C631(0.76); C496(0.93)  LDD1512  [17]
 LDCM0270  AC15 HEK-293T C631(1.27); C496(1.25)  LDD1513  [17]
 LDCM0276  AC17 HEK-293T C631(1.11); C496(0.90)  LDD1515  [17]
 LDCM0277  AC18 HEK-293T C631(0.93); C496(1.00)  LDD1516  [17]
 LDCM0278  AC19 HEK-293T C631(1.12); C496(1.08)  LDD1517  [17]
 LDCM0279  AC2 HEK-293T C631(1.12); C496(1.07)  LDD1518  [17]
 LDCM0280  AC20 HEK-293T C631(1.00); C496(1.06)  LDD1519  [17]
 LDCM0281  AC21 HEK-293T C496(1.13)  LDD1520  [17]
 LDCM0282  AC22 HEK-293T C631(0.90); C496(1.09)  LDD1521  [17]
 LDCM0283  AC23 HEK-293T C631(1.03); C496(1.15)  LDD1522  [17]
 LDCM0284  AC24 HEK-293T C631(1.46); C496(0.91)  LDD1523  [17]
 LDCM0285  AC25 HEK-293T C631(1.03); C496(0.89)  LDD1524  [17]
 LDCM0286  AC26 HEK-293T C631(0.99); C496(1.01)  LDD1525  [17]
 LDCM0287  AC27 HEK-293T C631(0.97); C496(1.14)  LDD1526  [17]
 LDCM0288  AC28 HEK-293T C631(1.03); C496(1.12)  LDD1527  [17]
 LDCM0289  AC29 HEK-293T C496(1.15)  LDD1528  [17]
 LDCM0290  AC3 HEK-293T C631(0.98); C496(0.97)  LDD1529  [17]
 LDCM0291  AC30 HEK-293T C631(0.89); C496(1.04)  LDD1530  [17]
 LDCM0292  AC31 HEK-293T C631(1.03); C496(1.24)  LDD1531  [17]
 LDCM0293  AC32 HEK-293T C631(1.62); C496(0.98)  LDD1532  [17]
 LDCM0294  AC33 HEK-293T C631(1.20); C496(0.81)  LDD1533  [17]
 LDCM0295  AC34 HEK-293T C631(1.05); C496(1.11)  LDD1534  [17]
 LDCM0296  AC35 HEK-293T C631(0.99); C496(1.00)  LDD1535  [17]
 LDCM0297  AC36 HEK-293T C631(0.85); C496(1.03)  LDD1536  [17]
 LDCM0298  AC37 HEK-293T C496(1.17)  LDD1537  [17]
 LDCM0299  AC38 HEK-293T C631(0.70); C496(1.11)  LDD1538  [17]
 LDCM0300  AC39 HEK-293T C631(1.20); C496(1.16)  LDD1539  [17]
 LDCM0301  AC4 HEK-293T C631(1.02); C496(0.98)  LDD1540  [17]
 LDCM0302  AC40 HEK-293T C631(1.37); C496(1.13)  LDD1541  [17]
 LDCM0303  AC41 HEK-293T C631(1.20); C496(0.95)  LDD1542  [17]
 LDCM0304  AC42 HEK-293T C631(1.17); C496(1.02)  LDD1543  [17]
 LDCM0305  AC43 HEK-293T C631(1.10); C496(1.10)  LDD1544  [17]
 LDCM0306  AC44 HEK-293T C631(0.91); C496(0.99)  LDD1545  [17]
 LDCM0307  AC45 HEK-293T C496(1.11)  LDD1546  [17]
 LDCM0308  AC46 HEK-293T C631(0.74); C496(1.01)  LDD1547  [17]
 LDCM0309  AC47 HEK-293T C631(1.21); C496(1.32)  LDD1548  [17]
 LDCM0310  AC48 HEK-293T C631(1.35); C496(1.12)  LDD1549  [17]
 LDCM0311  AC49 HEK-293T C631(1.23); C496(0.97)  LDD1550  [17]
 LDCM0312  AC5 HEK-293T C496(1.08)  LDD1551  [17]
 LDCM0313  AC50 HEK-293T C631(0.99); C496(0.97)  LDD1552  [17]
 LDCM0314  AC51 HEK-293T C631(1.10); C496(1.16)  LDD1553  [17]
 LDCM0315  AC52 HEK-293T C631(1.02); C496(0.86)  LDD1554  [17]
 LDCM0316  AC53 HEK-293T C496(1.07)  LDD1555  [17]
 LDCM0317  AC54 HEK-293T C631(0.69); C496(0.97)  LDD1556  [17]
 LDCM0318  AC55 HEK-293T C631(1.00); C496(1.19)  LDD1557  [17]
 LDCM0319  AC56 HEK-293T C631(1.44); C496(1.05)  LDD1558  [17]
 LDCM0320  AC57 HEK-293T C631(1.03); C496(0.97)  LDD1559  [17]
 LDCM0321  AC58 HEK-293T C631(0.89); C496(1.20)  LDD1560  [17]
 LDCM0322  AC59 HEK-293T C631(0.74); C496(1.18)  LDD1561  [17]
 LDCM0323  AC6 HEK-293T C631(0.88); C496(0.93)  LDD1562  [17]
 LDCM0324  AC60 HEK-293T C631(0.82); C496(0.98)  LDD1563  [17]
 LDCM0325  AC61 HEK-293T C496(1.02)  LDD1564  [17]
 LDCM0326  AC62 HEK-293T C631(0.83); C496(1.05)  LDD1565  [17]
 LDCM0327  AC63 HEK-293T C631(0.93); C496(1.26)  LDD1566  [17]
 LDCM0328  AC64 HEK-293T C631(0.98); C496(1.22)  LDD1567  [17]
 LDCM0334  AC7 HEK-293T C631(1.10); C496(1.19)  LDD1568  [17]
 LDCM0345  AC8 HEK-293T C631(0.93); C496(1.07)  LDD1569  [17]
 LDCM0248  AKOS034007472 HEK-293T C496(1.11)  LDD1511  [17]
 LDCM0356  AKOS034007680 HEK-293T C631(1.18); C496(0.93)  LDD1570  [17]
 LDCM0275  AKOS034007705 HEK-293T C631(1.57); C496(0.93)  LDD1514  [17]
 LDCM0632  CL-Sc Hep-G2 C631(0.66)  LDD2227  [15]
 LDCM0367  CL1 HEK-293T C631(0.87); C496(1.00)  LDD1571  [17]
 LDCM0368  CL10 HEK-293T C631(1.30); C496(0.77)  LDD1572  [17]
 LDCM0369  CL100 HEK-293T C631(1.01); C496(0.95)  LDD1573  [17]
 LDCM0370  CL101 HEK-293T C631(1.10); C496(0.98)  LDD1574  [17]
 LDCM0371  CL102 HEK-293T C631(1.07); C496(1.01)  LDD1575  [17]
 LDCM0372  CL103 HEK-293T C631(1.26); C496(1.01)  LDD1576  [17]
 LDCM0373  CL104 HEK-293T C631(1.00); C496(1.03)  LDD1577  [17]
 LDCM0374  CL105 HEK-293T C631(1.03); C496(0.86)  LDD1578  [17]
 LDCM0375  CL106 HEK-293T C631(1.01); C496(1.10)  LDD1579  [17]
 LDCM0376  CL107 HEK-293T C631(1.04); C496(1.05)  LDD1580  [17]
 LDCM0377  CL108 HEK-293T C631(1.00); C496(1.08)  LDD1581  [17]
 LDCM0378  CL109 HEK-293T C631(1.14); C496(1.01)  LDD1582  [17]
 LDCM0379  CL11 HEK-293T C631(0.93); C496(1.16)  LDD1583  [17]
 LDCM0380  CL110 HEK-293T C631(0.92); C496(1.00)  LDD1584  [17]
 LDCM0381  CL111 HEK-293T C631(1.01); C496(0.90)  LDD1585  [17]
 LDCM0382  CL112 HEK-293T C631(1.12); C496(0.95)  LDD1586  [17]
 LDCM0383  CL113 HEK-293T C631(1.05); C496(0.96)  LDD1587  [17]
 LDCM0384  CL114 HEK-293T C631(0.96); C496(0.97)  LDD1588  [17]
 LDCM0385  CL115 HEK-293T C631(1.08); C496(1.03)  LDD1589  [17]
 LDCM0386  CL116 HEK-293T C631(1.08); C496(1.14)  LDD1590  [17]
 LDCM0387  CL117 HEK-293T C631(1.04); C496(1.35)  LDD1591  [17]
 LDCM0388  CL118 HEK-293T C631(1.02); C496(1.06)  LDD1592  [17]
 LDCM0389  CL119 HEK-293T C631(1.11); C496(1.12)  LDD1593  [17]
 LDCM0390  CL12 HEK-293T C631(1.11); C496(1.05)  LDD1594  [17]
 LDCM0391  CL120 HEK-293T C631(1.17); C496(0.91)  LDD1595  [17]
 LDCM0392  CL121 HEK-293T C631(1.12); C496(0.91)  LDD1596  [17]
 LDCM0393  CL122 HEK-293T C631(1.02); C496(1.05)  LDD1597  [17]
 LDCM0394  CL123 HEK-293T C631(0.90); C496(1.01)  LDD1598  [17]
 LDCM0395  CL124 HEK-293T C631(1.04); C496(1.02)  LDD1599  [17]
 LDCM0396  CL125 HEK-293T C631(0.69); C496(1.11)  LDD1600  [17]
 LDCM0397  CL126 HEK-293T C631(0.78); C496(1.00)  LDD1601  [17]
 LDCM0398  CL127 HEK-293T C631(0.81); C496(0.95)  LDD1602  [17]
 LDCM0399  CL128 HEK-293T C631(0.84); C496(1.02)  LDD1603  [17]
 LDCM0400  CL13 HEK-293T C631(0.90); C496(0.83)  LDD1604  [17]
 LDCM0401  CL14 HEK-293T C631(1.03); C496(1.03)  LDD1605  [17]
 LDCM0402  CL15 HEK-293T C631(0.86); C496(0.90)  LDD1606  [17]
 LDCM0403  CL16 HEK-293T C631(0.92); C496(1.10)  LDD1607  [17]
 LDCM0404  CL17 HEK-293T C631(1.16); C496(0.67)  LDD1608  [17]
 LDCM0405  CL18 HEK-293T C631(0.88); C496(0.81)  LDD1609  [17]
 LDCM0406  CL19 HEK-293T C631(0.90); C496(1.09)  LDD1610  [17]
 LDCM0407  CL2 HEK-293T C631(0.87); C496(0.96)  LDD1611  [17]
 LDCM0408  CL20 HEK-293T C631(1.14); C496(0.94)  LDD1612  [17]
 LDCM0409  CL21 HEK-293T C496(0.93)  LDD1613  [17]
 LDCM0410  CL22 HEK-293T C631(0.79); C496(1.07)  LDD1614  [17]
 LDCM0411  CL23 HEK-293T C631(1.12); C496(1.14)  LDD1615  [17]
 LDCM0412  CL24 HEK-293T C631(1.18); C496(0.89)  LDD1616  [17]
 LDCM0413  CL25 HEK-293T C631(0.71); C496(0.79)  LDD1617  [17]
 LDCM0414  CL26 HEK-293T C631(1.03); C496(1.03)  LDD1618  [17]
 LDCM0415  CL27 HEK-293T C631(1.10); C496(1.02)  LDD1619  [17]
 LDCM0416  CL28 HEK-293T C631(1.09); C496(0.85)  LDD1620  [17]
 LDCM0417  CL29 HEK-293T C631(1.24); C496(0.92)  LDD1621  [17]
 LDCM0418  CL3 HEK-293T C631(0.87); C496(0.91)  LDD1622  [17]
 LDCM0419  CL30 HEK-293T C631(0.98); C496(1.07)  LDD1623  [17]
 LDCM0420  CL31 HEK-293T C631(1.00); C496(1.03)  LDD1624  [17]
 LDCM0421  CL32 HEK-293T C631(1.08); C496(0.95)  LDD1625  [17]
 LDCM0422  CL33 HEK-293T C496(0.79)  LDD1626  [17]
 LDCM0423  CL34 HEK-293T C631(0.70); C496(0.94)  LDD1627  [17]
 LDCM0424  CL35 HEK-293T C631(1.05); C496(1.11)  LDD1628  [17]
 LDCM0425  CL36 HEK-293T C631(1.21); C496(1.00)  LDD1629  [17]
 LDCM0426  CL37 HEK-293T C631(0.74); C496(1.04)  LDD1630  [17]
 LDCM0428  CL39 HEK-293T C631(1.03); C496(0.94)  LDD1632  [17]
 LDCM0429  CL4 HEK-293T C631(0.78); C496(0.86)  LDD1633  [17]
 LDCM0430  CL40 HEK-293T C631(1.10); C496(1.01)  LDD1634  [17]
 LDCM0431  CL41 HEK-293T C631(1.11); C496(1.04)  LDD1635  [17]
 LDCM0432  CL42 HEK-293T C631(0.88); C496(0.94)  LDD1636  [17]
 LDCM0433  CL43 HEK-293T C631(1.24); C496(1.13)  LDD1637  [17]
 LDCM0434  CL44 HEK-293T C631(1.20); C496(1.04)  LDD1638  [17]
 LDCM0435  CL45 HEK-293T C496(0.97)  LDD1639  [17]
 LDCM0436  CL46 HEK-293T C631(0.88); C496(1.00)  LDD1640  [17]
 LDCM0437  CL47 HEK-293T C631(0.92); C496(1.22)  LDD1641  [17]
 LDCM0438  CL48 HEK-293T C631(1.27); C496(0.95)  LDD1642  [17]
 LDCM0439  CL49 HEK-293T C631(0.86); C496(1.12)  LDD1643  [17]
 LDCM0440  CL5 HEK-293T C631(0.99); C496(0.82)  LDD1644  [17]
 LDCM0441  CL50 HEK-293T C631(1.02); C496(0.93)  LDD1645  [17]
 LDCM0443  CL52 HEK-293T C631(1.07); C496(0.91)  LDD1646  [17]
 LDCM0444  CL53 HEK-293T C631(1.18); C496(0.83)  LDD1647  [17]
 LDCM0445  CL54 HEK-293T C631(0.87); C496(0.95)  LDD1648  [17]
 LDCM0446  CL55 HEK-293T C631(0.95); C496(1.25)  LDD1649  [17]
 LDCM0447  CL56 HEK-293T C631(0.88); C496(1.05)  LDD1650  [17]
 LDCM0448  CL57 HEK-293T C496(0.95)  LDD1651  [17]
 LDCM0449  CL58 HEK-293T C631(0.60); C496(1.07)  LDD1652  [17]
 LDCM0450  CL59 HEK-293T C631(0.87); C496(1.31)  LDD1653  [17]
 LDCM0451  CL6 HEK-293T C631(0.73); C496(0.91)  LDD1654  [17]
 LDCM0452  CL60 HEK-293T C631(1.29); C496(1.03)  LDD1655  [17]
 LDCM0453  CL61 HEK-293T C631(0.88); C496(1.11)  LDD1656  [17]
 LDCM0454  CL62 HEK-293T C631(1.03); C496(1.08)  LDD1657  [17]
 LDCM0455  CL63 HEK-293T C631(1.12); C496(1.02)  LDD1658  [17]
 LDCM0456  CL64 HEK-293T C631(1.03); C496(0.62)  LDD1659  [17]
 LDCM0457  CL65 HEK-293T C631(1.28); C496(0.89)  LDD1660  [17]
 LDCM0458  CL66 HEK-293T C631(0.95); C496(1.09)  LDD1661  [17]
 LDCM0459  CL67 HEK-293T C631(1.16); C496(1.10)  LDD1662  [17]
 LDCM0460  CL68 HEK-293T C631(0.81); C496(0.95)  LDD1663  [17]
 LDCM0461  CL69 HEK-293T C496(1.01)  LDD1664  [17]
 LDCM0462  CL7 HEK-293T C631(0.86); C496(1.10)  LDD1665  [17]
 LDCM0463  CL70 HEK-293T C631(0.77); C496(1.06)  LDD1666  [17]
 LDCM0464  CL71 HEK-293T C631(1.30); C496(1.34)  LDD1667  [17]
 LDCM0465  CL72 HEK-293T C631(1.08); C496(1.12)  LDD1668  [17]
 LDCM0466  CL73 HEK-293T C631(0.81); C496(1.15)  LDD1669  [17]
 LDCM0467  CL74 HEK-293T C631(0.95); C496(1.21)  LDD1670  [17]
 LDCM0469  CL76 HEK-293T C631(1.02); C496(0.97)  LDD1672  [17]
 LDCM0470  CL77 HEK-293T C631(1.08); C496(0.88)  LDD1673  [17]
 LDCM0471  CL78 HEK-293T C631(0.93); C496(1.09)  LDD1674  [17]
 LDCM0472  CL79 HEK-293T C631(1.10); C496(1.23)  LDD1675  [17]
 LDCM0473  CL8 HEK-293T C631(0.59); C496(0.74)  LDD1676  [17]
 LDCM0474  CL80 HEK-293T C631(1.10); C496(1.05)  LDD1677  [17]
 LDCM0475  CL81 HEK-293T C496(1.19)  LDD1678  [17]
 LDCM0476  CL82 HEK-293T C631(0.68); C496(1.07)  LDD1679  [17]
 LDCM0477  CL83 HEK-293T C631(1.12); C496(1.36)  LDD1680  [17]
 LDCM0478  CL84 HEK-293T C631(1.24); C496(1.12)  LDD1681  [17]
 LDCM0479  CL85 HEK-293T C631(0.59); C496(1.02)  LDD1682  [17]
 LDCM0480  CL86 HEK-293T C631(0.57); C496(1.02)  LDD1683  [17]
 LDCM0481  CL87 HEK-293T C631(0.67); C496(0.95)  LDD1684  [17]
 LDCM0482  CL88 HEK-293T C631(0.74); C496(1.04)  LDD1685  [17]
 LDCM0483  CL89 HEK-293T C631(0.89); C496(0.90)  LDD1686  [17]
 LDCM0484  CL9 HEK-293T C496(0.98)  LDD1687  [17]
 LDCM0485  CL90 HEK-293T C631(0.60); C496(0.79)  LDD1688  [17]
 LDCM0486  CL91 HEK-293T C631(0.68); C496(1.32)  LDD1689  [17]
 LDCM0487  CL92 HEK-293T C631(0.78); C496(1.02)  LDD1690  [17]
 LDCM0488  CL93 HEK-293T C496(1.08)  LDD1691  [17]
 LDCM0489  CL94 HEK-293T C631(0.91); C496(0.93)  LDD1692  [17]
 LDCM0490  CL95 HEK-293T C631(1.13); C496(0.93)  LDD1693  [17]
 LDCM0491  CL96 HEK-293T C631(0.75); C496(0.95)  LDD1694  [17]
 LDCM0492  CL97 HEK-293T C631(0.91); C496(0.92)  LDD1695  [17]
 LDCM0493  CL98 HEK-293T C631(1.04); C496(0.94)  LDD1696  [17]
 LDCM0494  CL99 HEK-293T C631(0.95); C496(0.96)  LDD1697  [17]
 LDCM0634  CY-0357 Hep-G2 C631(2.59)  LDD2228  [15]
 LDCM0495  E2913 HEK-293T C631(1.00); C496(1.00)  LDD1698  [17]
 LDCM0468  Fragment33 HEK-293T C631(0.98); C496(0.91)  LDD1671  [17]
 LDCM0427  Fragment51 HEK-293T C631(1.08); C496(1.00)  LDD1631  [17]
 LDCM0116  HHS-0101 DM93 Y18(0.42)  LDD0264  [4]
 LDCM0117  HHS-0201 DM93 Y18(0.14); Y40(1.74)  LDD0265  [4]
 LDCM0118  HHS-0301 DM93 Y18(0.15)  LDD0266  [4]
 LDCM0119  HHS-0401 DM93 Y40(0.55); Y18(0.55)  LDD0267  [4]
 LDCM0120  HHS-0701 DM93 Y18(0.44); Y40(2.03)  LDD0268  [4]
 LDCM0022  KB02 HEK-293T C631(1.07)  LDD1492  [17]
 LDCM0023  KB03 HEK-293T C631(0.97)  LDD1497  [17]
 LDCM0024  KB05 G361 C496(1.38)  LDD3311  [2]
 LDCM0511  Nucleophilic fragment 18b MDA-MB-231 C64(0.45)  LDD2104  [3]
 LDCM0513  Nucleophilic fragment 19b MDA-MB-231 C64(0.75)  LDD2106  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C64(0.53)  LDD2107  [3]
 LDCM0515  Nucleophilic fragment 20b MDA-MB-231 C64(0.65)  LDD2108  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C64(1.13)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C64(1.01)  LDD2120  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C64(0.66)  LDD2125  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C64(1.49)  LDD2128  [3]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C64(1.01)  LDD2129  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C64(0.80)  LDD2136  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C64(0.34)  LDD2140  [3]
 LDCM0547  Nucleophilic fragment 41 MDA-MB-231 C64(0.39)  LDD2141  [3]
 LDCM0551  Nucleophilic fragment 5b MDA-MB-231 C64(0.57)  LDD2145  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C64(0.88)  LDD2146  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Telomeric repeat-binding factor 2 (TERF2) . Q15554

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
5 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
6 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.
7 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
8 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
9 SP3-Enabled Rapid and High Coverage Chemoproteomic Identification of Cell-State-Dependent Redox-Sensitive Cysteines. Mol Cell Proteomics. 2022 Apr;21(4):100218. doi: 10.1016/j.mcpro.2022.100218. Epub 2022 Feb 25.
Mass spectrometry data entry: PXD029500 , PXD031647
10 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
11 Solid Phase Synthesis of Fluorosulfate Containing Macrocycles for Chemoproteomic Workflows. bioRxiv [Preprint]. 2023 Feb 18:2023.02.17.529022. doi: 10.1101/2023.02.17.529022.
Mass spectrometry data entry: PXD039931
12 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
13 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
14 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
15 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
16 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
17 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402