Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C297  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 35 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01039  Protein-S-isoprenylcysteine O-methyltransferase (ICMT) 21.4
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 18.6
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 16.4
 LDTP01769  Dihydrofolate reductase (DHFR) 16.3
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 14.8
 LDTP01803  Adenosine deaminase (ADA) 14.3
 LDTP15484  Saccharopine dehydrogenase-like oxidoreductase (SCCPDH) 13.0
 LDTP05029  Peptidyl-prolyl cis-trans isomerase FKBP1A (FKBP1A) 12.0
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 11.9
 LDTP09088  Phospholipase A2 group XV (PLA2G15) 11.2
 LDTP06648  Lanosterol 14-alpha demethylase (CYP51A1) 10.3
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 10.1
 LDTP11273  N-terminal Xaa-Pro-Lys N-methyltransferase 1 (NTMT1) 9.3
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 9.3
 LDTP11081  NAD-capped RNA hydrolase NUDT12 (NUDT12) 8.9
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 8.2
 LDTP03257  Carnitine O-palmitoyltransferase 2, mitochondrial (CPT2) 7.9
 LDTP12197  Ethanolamine kinase 1 (ETNK1) 7.7
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 7.5
 LDTP03374  Peptidyl-prolyl cis-trans isomerase FKBP2 (FKBP2) 7.4
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 7.4
 LDTP12279  Endoplasmic reticulum transmembrane helix translocase (ATP13A1) 7.2
 LDTP15328  Dolichyldiphosphatase 1 (DOLPP1) 6.9
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 6.6
 LDTP04712  Puromycin-sensitive aminopeptidase (NPEPPS) 6.6
 LDTP00988  Protein O-GlcNAcase (OGA) 6.5
 LDTP03842  Squalene synthase (FDFT1) 6.2
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 6.1
 LDTP01328  CAAX prenyl protease 1 homolog (ZMPSTE24) 5.9
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 5.7
 LDTP06849  Prolyl endopeptidase-like (PREPL) 5.6
 LDTP13154  E3 ubiquitin-protein ligase RNF14 (RNF14) 5.5
 LDTP02254  ATP-dependent translocase ABCB1 (ABCB1) 5.3
 LDTP04008  Endothelin-converting enzyme 1 (ECE1) 5.2
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.0
Transporter and channel
Click to Show/Hide to Show 22 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 20.4
 LDTP16069  Peroxisomal membrane protein 2 (PXMP2) 20.4
 LDTP01804  ATP synthase subunit a (MT-ATP6) 16.2
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 12.8
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 11.9
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 11.6
 LDTP00262  Acetyl-coenzyme A transporter 1 (SLC33A1) 10.0
 LDTP13262  Signal recognition particle subunit SRP68 (SRP68) 9.9
 LDTP07236  Protein GPR107 (GPR107) 8.9
 LDTP04592  Monocarboxylate transporter 1 (SLC16A1) 8.9
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 8.7
 LDTP14952  Mpv17-like protein 2 (MPV17L2) 8.0
 LDTP07885  Mitochondrial S-adenosylmethionine carrier protein (SLC25A26) 7.7
 LDTP07156  Protein wntless homolog (WLS) 7.5
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 7.2
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 6.9
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 6.6
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 6.2
 LDTP07462  MFS-type transporter SLC18B1 (SLC18B1) 5.6
 LDTP06945  Sigma intracellular receptor 2 (TMEM97) 5.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 5.0
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 4.9
Other
Click to Show/Hide to Show 18 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 11.6
 LDTP08081  Hepatoma-derived growth factor-related protein 2 (HDGFL2) 11.5
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 9.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 8.6
 LDTP14058  Rap guanine nucleotide exchange factor 2 (RAPGEF2) 7.9
 LDTP00105  Protein unc-119 homolog B (UNC119B) 7.5
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 7.1
 LDTP11076  Apolipoprotein L2 (APOL2) 6.9
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 6.5
 LDTP04483  Hepatoma-derived growth factor (HDGF) 6.5
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 6.1
 LDTP15714  Mdm2-binding protein (MTBP) 6.0
 LDTP11044  Polyadenylate-binding protein-interacting protein 2 (PAIP2) 6.0
 LDTP19021  EF-hand calcium-binding domain-containing protein 14 (EFCAB14) 5.8
 LDTP02345  Retinol-binding protein 1 (RBP1) 5.5
 LDTP07934  Synaptic vesicle glycoprotein 2A (SV2A) 5.3
 LDTP18883  Protein CEBPZOS (CEBPZOS) 5.1
 LDTP05160  Nucleobindin-2 (NUCB2) 4.9

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587