Details of the Target

General Information of Target

Target ID LDTP00988
Target Name Protein O-GlcNAcase (OGA)
Gene Name OGA
Gene ID 10724
Synonyms
HEXC; KIAA0679; MEA5; MGEA5; Protein O-GlcNAcase; OGA; EC 3.2.1.169; Beta-N-acetylglucosaminidase; Beta-N-acetylhexosaminidase; Beta-hexosaminidase; Meningioma-expressed antigen 5; N-acetyl-beta-D-glucosaminidase; N-acetyl-beta-glucosaminidase; Nuclear cytoplasmic O-GlcNAcase and acetyltransferase; NCOAT
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVQKESQATLEERESELSSNPAASAGASLEPPAAPAPGEDNPAGAGGAAVAGAAGGARRF
LCGVVEGFYGRPWVMEQRKELFRRLQKWELNTYLYAPKDDYKHRMFWREMYSVEEAEQLM
TLISAAREYEIEFIYAISPGLDITFSNPKEVSTLKRKLDQVSQFGCRSFALLFDDIDHNM
CAADKEVFSSFAHAQVSITNEIYQYLGEPETFLFCPTEYCGTFCYPNVSQSPYLRTVGEK
LLPGIEVLWTGPKVVSKEIPVESIEEVSKIIKRAPVIWDNIHANDYDQKRLFLGPYKGRS
TELIPRLKGVLTNPNCEFEANYVAIHTLATWYKSNMNGVRKDVVMTDSEDSTVSIQIKLE
NEGSDEDIETDVLYSPQMALKLALTEWLQEFGVPHQYSSRQVAHSGAKASVVDGTPLVAA
PSLNATTVVTTVYQEPIMSQGAALSGEPTTLTKEEEKKQPDEEPMDMVVEKQEETDHKND
NQILSEIVEAKMAEELKPMDTDKESIAESKSPEMSMQEDCISDIAPMQTDEQTNKEQFVP
GPNEKPLYTAEPVTLEDLQLLADLFYLPYEHGPKGAQMLREFQWLRANSSVVSVNCKGKD
SEKIEEWRSRAAKFEEMCGLVMGMFTRLSNCANRTILYDMYSYVWDIKSIMSMVKSFVQW
LGCRSHSSAQFLIGDQEPWAFRGGLAGEFQRLLPIDGANDLFFQPPPLTPTSKVYTIRPY
FPKDEASVYKICREMYDDGVGLPFQSQPDLIGDKLVGGLLSLSLDYCFVLEDEDGICGYA
LGTVDVTPFIKKCKISWIPFMQEKYTKPNGDKELSEAEKIMLSFHEEQEVLPETFLANFP
SLIKMDIHKKVTDPSVAKSMMACLLSSLKANGSRGAFCEVRPDDKRILEFYSKLGCFEIA
KMEGFPKDVVILGRSL
Target Type
Clinical trial
Target Bioclass
Enzyme
Family
Glycosyl hydrolase 84 family
Subcellular location
Cytoplasm; Nucleus
Function
[Isoform 1]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins . Deglycosylates a large and diverse number of proteins, such as CRYAB, ELK1, LMNB1 and TAB1. Can use p-nitrophenyl-beta-GlcNAc and 4-methylumbelliferone-GlcNAc as substrates but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro). Does not bind acetyl-CoA and does not have histone acetyltransferase activity.; [Isoform 3]: Cleaves GlcNAc but not GalNAc from O-glycosylated proteins. Can use p-nitrophenyl-beta-GlcNAc as substrate but not p-nitrophenyl-beta-GalNAc or p-nitrophenyl-alpha-GlcNAc (in vitro), but has about six times lower specific activity than isoform 1.
TTD ID
T19567
Uniprot ID
O60502
DrugMap ID
TT2I6UX
Ensemble ID
ENST00000357797.9
HGNC ID
HGNC:7056
ChEMBL ID
CHEMBL5921

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
DETROIT562 SNV: p.K341I DBIA    Probe Info 
ETK1 SNV: p.G67Ter DBIA    Probe Info 
HCT15 SNV: p.T415I DBIA    Probe Info 
NCIH2286 SNV: p.Y548C DBIA    Probe Info 
SNGM SNV: p.D563G DBIA    Probe Info 

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 30 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
m-APA
 Probe Info  		14.93  LDD0402  [1]
TH211
 Probe Info  		Y805(17.85); Y715(12.99); Y729(7.71)  LDD0257  [2]
TH214
 Probe Info  		Y805(6.50)  LDD0258  [2]
TH216
 Probe Info  		Y720(20.00); Y805(20.00)  LDD0259  [2]
BTD
 Probe Info  		C631(6.26)  LDD1699  [3]
Probe 1
 Probe Info  		Y729(19.80); Y736(13.48)  LDD3495  [4]
AHL-Pu-1
 Probe Info  		C896(2.26)  LDD0168  [5]
HHS-475
 Probe Info  		Y805(0.38); Y397(0.86); Y729(1.83)  LDD0264  [6]
HHS-465
 Probe Info  		Y397(8.86)  LDD2237  [7]
DBIA
 Probe Info  		C596(1.02); C896(0.97); C663(0.96)  LDD0078  [8]
4-Iodoacetamidophenylacetylene
 Probe Info  		C596(0.00); C62(0.00); C878(0.00); C631(0.00)  LDD0038  [9]
IA-alkyne
 Probe Info  		C316(0.00); C631(0.00)  LDD0032  [10]
Lodoacetamide azide
 Probe Info  		C596(0.00); C618(0.00); C62(0.00); C878(0.00)  LDD0037  [9]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [11]
NAIA_4
 Probe Info  		N.A.  LDD2226  [12]
TFBX
 Probe Info  		N.A.  LDD0027  [11]
WYneN
 Probe Info  		C878(0.00); C631(0.00)  LDD0021  [13]
WYneO
 Probe Info  		N.A.  LDD0022  [13]
Compound 10
 Probe Info  		N.A.  LDD2216  [14]
Compound 11
 Probe Info  		N.A.  LDD2213  [14]
ENE
 Probe Info  		N.A.  LDD0006  [13]
IPM
 Probe Info  		C663(0.00); C896(0.00); C596(0.00)  LDD0005  [13]
Ox-W18
 Probe Info  		N.A.  LDD2175  [15]
1c-yne
 Probe Info  		K257(0.00); K858(0.00)  LDD0228  [16]
Acrolein
 Probe Info  		C896(0.00); C596(0.00)  LDD0217  [17]
Methacrolein
 Probe Info  		C596(0.00); C896(0.00)  LDD0218  [17]
W1
 Probe Info  		C863(0.00); C631(0.00)  LDD0236  [18]
AOyne
 Probe Info  		15.00  LDD0443  [19]
NAIA_5
 Probe Info  		C878(0.00); C166(0.00); C896(0.00); C62(0.00)  LDD2223  [12]
HHS-482
 Probe Info  		Y805(1.72)  LDD2239  [7]
PAL-AfBPP Probe
Click To Hide/Show 95 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		7.31  LDD1714  [20]
C010
 Probe Info  		6.36  LDD1719  [20]
C011
 Probe Info  		5.58  LDD1720  [20]
C022
 Probe Info  		9.32  LDD1728  [20]
C026
 Probe Info  		8.88  LDD1732  [20]
C041
 Probe Info  		8.88  LDD1741  [20]
C055
 Probe Info  		14.03  LDD1752  [20]
C063
 Probe Info  		12.73  LDD1760  [20]
C064
 Probe Info  		6.96  LDD1761  [20]
C070
 Probe Info  		11.00  LDD1766  [20]
C107
 Probe Info  		7.26  LDD1794  [20]
C130
 Probe Info  		8.57  LDD1812  [20]
C135
 Probe Info  		15.35  LDD1817  [20]
C141
 Probe Info  		11.16  LDD1823  [20]
C143
 Probe Info  		13.09  LDD1825  [20]
C145
 Probe Info  		10.20  LDD1827  [20]
C147
 Probe Info  		10.48  LDD1829  [20]
C159
 Probe Info  		17.15  LDD1839  [20]
C160
 Probe Info  		10.27  LDD1840  [20]
C161
 Probe Info  		11.00  LDD1841  [20]
C163
 Probe Info  		6.23  LDD1843  [20]
C173
 Probe Info  		17.51  LDD1853  [20]
C177
 Probe Info  		10.78  LDD1856  [20]
C178
 Probe Info  		17.03  LDD1857  [20]
C183
 Probe Info  		5.50  LDD1861  [20]
C185
 Probe Info  		7.36  LDD1863  [20]
C191
 Probe Info  		18.51  LDD1868  [20]
C193
 Probe Info  		5.43  LDD1869  [20]
C194
 Probe Info  		11.00  LDD1870  [20]
C199
 Probe Info  		5.31  LDD1875  [20]
C204
 Probe Info  		10.06  LDD1879  [20]
C205
 Probe Info  		9.85  LDD1880  [20]
C206
 Probe Info  		18.77  LDD1881  [20]
C213
 Probe Info  		19.43  LDD1887  [20]
C216
 Probe Info  		7.26  LDD1890  [20]
C217
 Probe Info  		9.19  LDD1891  [20]
C218
 Probe Info  		11.71  LDD1892  [20]
C229
 Probe Info  		7.67  LDD1902  [20]
C232
 Probe Info  		36.25  LDD1905  [20]
C239
 Probe Info  		6.82  LDD1912  [20]
C249
 Probe Info  		16.56  LDD1922  [20]
C252
 Probe Info  		8.46  LDD1925  [20]
C260
 Probe Info  		9.00  LDD1932  [20]
C264
 Probe Info  		16.45  LDD1935  [20]
C265
 Probe Info  		22.16  LDD1936  [20]
C271
 Probe Info  		5.50  LDD1941  [20]
C272
 Probe Info  		4.96  LDD1942  [20]
C284
 Probe Info  		24.93  LDD1954  [20]
C287
 Probe Info  		8.94  LDD1957  [20]
C288
 Probe Info  		6.68  LDD1958  [20]
C290
 Probe Info  		10.13  LDD1960  [20]
C297
 Probe Info  		6.45  LDD1967  [20]
C301
 Probe Info  		7.84  LDD1970  [20]
C305
 Probe Info  		15.56  LDD1974  [20]
C307
 Probe Info  		5.58  LDD1975  [20]
C311
 Probe Info  		7.62  LDD1978  [20]
C314
 Probe Info  		12.82  LDD1981  [20]
C317
 Probe Info  		13.27  LDD1983  [20]
C322
 Probe Info  		6.54  LDD1988  [20]
C326
 Probe Info  		13.83  LDD1990  [20]
C335
 Probe Info  		6.06  LDD1998  [20]
C342
 Probe Info  		6.63  LDD2004  [20]
C349
 Probe Info  		11.24  LDD2010  [20]
C350
 Probe Info  		31.34  LDD2011  [20]
C354
 Probe Info  		8.88  LDD2015  [20]
C355
 Probe Info  		32.90  LDD2016  [20]
C356
 Probe Info  		13.74  LDD2017  [20]
C357
 Probe Info  		6.54  LDD2018  [20]
C361
 Probe Info  		25.81  LDD2022  [20]
C364
 Probe Info  		20.53  LDD2025  [20]
C367
 Probe Info  		5.43  LDD2028  [20]
C376
 Probe Info  		8.63  LDD2036  [20]
C380
 Probe Info  		5.50  LDD2039  [20]
C382
 Probe Info  		10.48  LDD2041  [20]
C387
 Probe Info  		5.31  LDD2046  [20]
C392
 Probe Info  		5.54  LDD2051  [20]
C399
 Probe Info  		16.91  LDD2058  [20]
C403
 Probe Info  		22.32  LDD2061  [20]
C413
 Probe Info  		13.27  LDD2069  [20]
C419
 Probe Info  		16.11  LDD2074  [20]
C420
 Probe Info  		19.16  LDD2075  [20]
C424
 Probe Info  		14.52  LDD2079  [20]
C428
 Probe Info  		7.57  LDD2083  [20]
C429
 Probe Info  		15.67  LDD2084  [20]
FFF probe11
 Probe Info  		20.00  LDD0471  [21]
FFF probe12
 Probe Info  		8.12  LDD0473  [21]
FFF probe13
 Probe Info  		20.00  LDD0475  [21]
FFF probe14
 Probe Info  		20.00  LDD0477  [21]
FFF probe15
 Probe Info  		8.66  LDD0478  [21]
FFF probe2
 Probe Info  		20.00  LDD0463  [21]
FFF probe3
 Probe Info  		17.90  LDD0464  [21]
FFF probe6
 Probe Info  		5.92  LDD0467  [21]
FFF probe7
 Probe Info  		7.58  LDD0483  [21]
JN0003
 Probe Info  		14.80  LDD0469  [21]
OEA-DA
 Probe Info  		12.91  LDD0046  [22]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0524  2-Cyano-N-(2-morpholin-4-yl-ethyl)-acetamide MDA-MB-231 C166(0.89); C596(1.18); C896(1.57)  LDD2117  [3]
 LDCM0025  4SU-RNA HEK-293T C896(2.26)  LDD0168  [5]
 LDCM0026  4SU-RNA+native RNA HEK-293T C896(2.65); C520(2.14)  LDD0169  [5]
 LDCM0214  AC1 HCT 116 C166(1.14); C596(1.14); C62(1.24); C631(1.32)  LDD0531  [8]
 LDCM0215  AC10 HCT 116 C166(0.87); C181(0.79); C596(1.07); C62(1.71)  LDD0532  [8]
 LDCM0216  AC100 HCT 116 C166(0.44); C596(1.03); C62(0.66); C631(0.77)  LDD0533  [8]
 LDCM0217  AC101 HCT 116 C166(0.40); C596(1.13); C62(0.59); C631(0.75)  LDD0534  [8]
 LDCM0218  AC102 HCT 116 C166(0.52); C596(1.03); C62(0.66); C631(0.85)  LDD0535  [8]
 LDCM0219  AC103 HCT 116 C166(0.34); C596(1.34); C62(0.41); C631(0.73)  LDD0536  [8]
 LDCM0220  AC104 HCT 116 C166(0.51); C596(1.23); C62(1.07); C631(0.71)  LDD0537  [8]
 LDCM0221  AC105 HCT 116 C166(0.35); C596(1.17); C62(0.49); C631(0.74)  LDD0538  [8]
 LDCM0222  AC106 HCT 116 C166(0.36); C596(1.20); C62(0.49); C631(0.68)  LDD0539  [8]
 LDCM0223  AC107 HCT 116 C166(0.49); C596(1.15); C62(0.63); C631(0.72)  LDD0540  [8]
 LDCM0224  AC108 HCT 116 C166(0.33); C596(1.30); C62(0.92); C631(0.94)  LDD0541  [8]
 LDCM0225  AC109 HCT 116 C166(0.52); C596(0.99); C62(0.98); C631(0.81)  LDD0542  [8]
 LDCM0226  AC11 HCT 116 C166(1.08); C181(0.80); C596(1.11); C62(3.13)  LDD0543  [8]
 LDCM0227  AC110 HCT 116 C166(0.32); C596(1.06); C62(0.46); C631(0.79)  LDD0544  [8]
 LDCM0228  AC111 HCT 116 C166(0.34); C596(1.17); C62(0.47); C631(0.81)  LDD0545  [8]
 LDCM0229  AC112 HCT 116 C166(0.36); C596(1.17); C62(0.47); C631(0.71)  LDD0546  [8]
 LDCM0230  AC113 HCT 116 C166(1.43); C181(1.06); C596(0.98); C62(1.30)  LDD0547  [8]
 LDCM0231  AC114 HCT 116 C166(0.89); C181(0.77); C596(1.17); C62(1.01)  LDD0548  [8]
 LDCM0232  AC115 HCT 116 C166(0.89); C181(0.65); C596(1.36); C62(0.74)  LDD0549  [8]
 LDCM0233  AC116 HCT 116 C166(0.94); C181(0.65); C596(1.41); C62(1.13)  LDD0550  [8]
 LDCM0234  AC117 HCT 116 C166(1.14); C181(0.72); C596(1.13); C62(1.28)  LDD0551  [8]
 LDCM0235  AC118 HCT 116 C166(1.07); C181(0.83); C596(1.14); C62(1.24)  LDD0552  [8]
 LDCM0236  AC119 HCT 116 C166(0.92); C181(0.80); C596(1.20); C62(1.02)  LDD0553  [8]
 LDCM0237  AC12 HCT 116 C166(1.20); C181(0.94); C596(1.05); C62(2.25)  LDD0554  [8]
 LDCM0238  AC120 HCT 116 C166(0.91); C181(0.68); C596(1.17); C62(1.17)  LDD0555  [8]
 LDCM0239  AC121 HCT 116 C166(1.47); C181(0.82); C596(1.16); C62(1.41)  LDD0556  [8]
 LDCM0240  AC122 HCT 116 C166(1.06); C181(0.82); C596(1.08); C62(1.34)  LDD0557  [8]
 LDCM0241  AC123 HCT 116 C166(1.36); C181(0.83); C596(1.00); C62(1.25)  LDD0558  [8]
 LDCM0242  AC124 HCT 116 C166(1.21); C181(0.95); C596(1.11); C62(1.16)  LDD0559  [8]
 LDCM0243  AC125 HCT 116 C166(0.97); C181(0.86); C596(1.11); C62(1.08)  LDD0560  [8]
 LDCM0244  AC126 HCT 116 C166(0.98); C181(0.71); C596(1.18); C62(1.11)  LDD0561  [8]
 LDCM0245  AC127 HCT 116 C166(1.10); C181(0.70); C596(1.18); C62(1.31)  LDD0562  [8]
 LDCM0246  AC128 HCT 116 C166(0.91); C596(1.20); C62(2.12); C896(0.83)  LDD0563  [8]
 LDCM0247  AC129 HCT 116 C166(1.29); C596(0.97); C62(1.51); C896(0.99)  LDD0564  [8]
 LDCM0249  AC130 HCT 116 C166(0.91); C596(1.24); C62(1.53); C896(1.17)  LDD0566  [8]
 LDCM0250  AC131 HCT 116 C166(1.27); C596(1.17); C62(1.10); C896(1.02)  LDD0567  [8]
 LDCM0251  AC132 HCT 116 C166(1.06); C596(0.98); C62(1.18); C896(1.40)  LDD0568  [8]
 LDCM0252  AC133 HCT 116 C166(0.94); C596(0.99); C62(1.56); C896(1.12)  LDD0569  [8]
 LDCM0253  AC134 HCT 116 C166(0.70); C596(1.24); C62(0.74); C896(1.32)  LDD0570  [8]
 LDCM0254  AC135 HCT 116 C166(0.84); C596(1.12); C62(1.01); C896(1.14)  LDD0571  [8]
 LDCM0255  AC136 HCT 116 C166(0.83); C596(1.20); C62(0.95); C896(1.39)  LDD0572  [8]
 LDCM0256  AC137 HCT 116 C166(0.92); C596(1.09); C62(0.90); C896(1.41)  LDD0573  [8]
 LDCM0257  AC138 HCT 116 C166(0.66); C596(1.20); C62(0.47); C896(2.05)  LDD0574  [8]
 LDCM0258  AC139 HCT 116 C166(0.83); C596(1.13); C62(0.64); C896(1.57)  LDD0575  [8]
 LDCM0259  AC14 HCT 116 C166(1.06); C181(0.95); C596(1.05); C62(2.35)  LDD0576  [8]
 LDCM0260  AC140 HCT 116 C166(0.70); C596(1.27); C62(0.50); C896(1.90)  LDD0577  [8]
 LDCM0261  AC141 HCT 116 C166(0.76); C596(1.28); C62(0.53); C896(1.85)  LDD0578  [8]
 LDCM0262  AC142 HCT 116 C166(1.30); C596(1.06); C62(0.86); C896(1.53)  LDD0579  [8]
 LDCM0263  AC143 HCT 116 C62(0.73); C896(0.96); C181(0.97); C166(0.97)  LDD0580  [8]
 LDCM0264  AC144 HCT 116 C166(0.87); C181(0.87); C631(0.90); C896(0.94)  LDD0581  [8]
 LDCM0265  AC145 HCT 116 C166(0.80); C631(0.81); C896(0.89); C181(0.89)  LDD0582  [8]
 LDCM0266  AC146 HCT 116 C896(0.76); C631(0.84); C62(0.87); C181(0.89)  LDD0583  [8]
 LDCM0267  AC147 HCT 116 C896(0.85); C181(0.85); C166(0.91); C631(1.15)  LDD0584  [8]
 LDCM0268  AC148 HCT 116 C181(0.72); C896(0.81); C166(0.95); C631(0.98)  LDD0585  [8]
 LDCM0269  AC149 HCT 116 C181(0.77); C631(0.82); C62(0.90); C896(1.02)  LDD0586  [8]
 LDCM0270  AC15 HCT 116 C181(0.80); C896(0.84); C166(0.90); C631(0.94)  LDD0587  [8]
 LDCM0271  AC150 HCT 116 C181(0.85); C896(0.95); C631(1.05); C663(1.10)  LDD0588  [8]
 LDCM0272  AC151 HCT 116 C62(0.81); C181(0.94); C166(0.99); C896(1.03)  LDD0589  [8]
 LDCM0273  AC152 HCT 116 C181(0.73); C62(0.74); C896(0.89); C631(1.01)  LDD0590  [8]
 LDCM0274  AC153 HCT 116 C62(0.44); C181(0.65); C896(0.90); C631(0.96)  LDD0591  [8]
 LDCM0621  AC154 HCT 116 C166(0.94); C181(0.82); C596(1.49); C62(0.85)  LDD2158  [8]
 LDCM0622  AC155 HCT 116 C166(1.12); C181(0.81); C596(1.19); C62(0.56)  LDD2159  [8]
 LDCM0623  AC156 HCT 116 C166(1.05); C181(1.00); C596(1.06); C62(0.87)  LDD2160  [8]
 LDCM0624  AC157 HCT 116 C166(0.99); C181(0.90); C596(1.19); C62(0.60)  LDD2161  [8]
 LDCM0276  AC17 HCT 116 C166(0.80); C663(1.03); C896(1.04); C596(1.18)  LDD0593  [8]
 LDCM0277  AC18 HCT 116 C166(0.58); C631(0.99); C896(1.04); C663(1.13)  LDD0594  [8]
 LDCM0278  AC19 HCT 116 C166(0.74); C663(0.98); C896(1.04); C631(1.05)  LDD0595  [8]
 LDCM0279  AC2 HCT 116 C863(0.70); C166(0.93); C631(0.94); C62(0.96)  LDD0596  [8]
 LDCM0280  AC20 HCT 116 C62(0.85); C631(0.87); C166(0.88); C663(1.02)  LDD0597  [8]
 LDCM0281  AC21 HCT 116 C166(0.76); C663(1.03); C896(1.03); C631(1.09)  LDD0598  [8]
 LDCM0282  AC22 HCT 116 C663(0.97); C166(1.07); C62(1.09); C631(1.19)  LDD0599  [8]
 LDCM0283  AC23 HCT 116 C166(0.75); C631(0.89); C663(1.01); C896(1.25)  LDD0600  [8]
 LDCM0284  AC24 HCT 116 C663(0.96); C166(0.98); C596(1.02); C896(1.03)  LDD0601  [8]
 LDCM0285  AC25 HCT 116 C166(0.75); C181(0.78); C631(0.89); C896(0.95)  LDD0602  [8]
 LDCM0286  AC26 HCT 116 C166(0.57); C631(0.79); C181(0.85); C596(1.04)  LDD0603  [8]
 LDCM0287  AC27 HCT 116 C166(0.60); C631(0.80); C181(0.95); C62(0.96)  LDD0604  [8]
 LDCM0288  AC28 HCT 116 C166(0.56); C631(0.75); C181(0.84); C596(1.00)  LDD0605  [8]
 LDCM0289  AC29 HCT 116 C62(0.53); C166(0.56); C181(0.82); C631(0.87)  LDD0606  [8]
 LDCM0290  AC3 HCT 116 C863(0.68); C896(0.96); C663(1.03); C62(1.05)  LDD0607  [8]
 LDCM0291  AC30 HCT 116 C166(0.53); C62(0.59); C631(0.74); C181(0.85)  LDD0608  [8]
 LDCM0292  AC31 HCT 116 C166(0.60); C631(0.71); C181(0.76); C62(0.98)  LDD0609  [8]
 LDCM0293  AC32 HCT 116 C166(0.40); C631(0.70); C181(0.73); C62(0.84)  LDD0610  [8]
 LDCM0294  AC33 HCT 116 C166(0.47); C631(0.75); C181(0.82); C62(0.89)  LDD0611  [8]
 LDCM0295  AC34 HCT 116 C166(0.45); C181(0.76); C631(0.80); C62(0.89)  LDD0612  [8]
 LDCM0296  AC35 HCT 116 C663(0.85); C596(0.92); C896(0.93); C181(1.01)  LDD0613  [8]
 LDCM0297  AC36 HCT 116 C663(0.81); C181(0.93); C896(1.05); C631(1.06)  LDD0614  [8]
 LDCM0298  AC37 HCT 116 C663(0.85); C181(0.93); C896(0.97); C596(0.97)  LDD0615  [8]
 LDCM0299  AC38 HCT 116 C631(0.89); C663(0.97); C181(0.97); C596(0.99)  LDD0616  [8]
 LDCM0300  AC39 HCT 116 C663(0.90); C181(0.92); C166(0.98); C596(1.03)  LDD0617  [8]
 LDCM0301  AC4 HCT 116 C863(0.59); C62(0.97); C631(1.00); C166(1.05)  LDD0618  [8]
 LDCM0302  AC40 HCT 116 C181(0.94); C663(0.98); C166(1.02); C896(1.14)  LDD0619  [8]
 LDCM0303  AC41 HCT 116 C631(0.68); C663(0.93); C166(1.00); C181(1.00)  LDD0620  [8]
 LDCM0304  AC42 HCT 116 C181(0.85); C166(0.88); C663(0.93); C631(1.05)  LDD0621  [8]
 LDCM0305  AC43 HCT 116 C631(0.69); C166(0.77); C663(0.98); C181(0.98)  LDD0622  [8]
 LDCM0306  AC44 HCT 116 C631(0.91); C663(0.92); C181(0.97); C896(1.05)  LDD0623  [8]
 LDCM0307  AC45 HCT 116 C181(0.80); C166(0.96); C663(0.98); C631(0.99)  LDD0624  [8]
 LDCM0308  AC46 HCT 116 C631(0.52); C863(0.67); C62(0.91); C166(0.94)  LDD0625  [8]
 LDCM0309  AC47 HCT 116 C863(0.80); C166(0.80); C631(1.08); C596(1.09)  LDD0626  [8]
 LDCM0310  AC48 HCT 116 C631(0.53); C863(0.72); C166(0.76); C596(1.00)  LDD0627  [8]
 LDCM0311  AC49 HCT 116 C631(0.43); C166(0.62); C863(0.74); C62(0.76)  LDD0628  [8]
 LDCM0312  AC5 HCT 116 C863(0.61); C166(0.98); C596(1.04); C62(1.09)  LDD0629  [8]
 LDCM0313  AC50 HCT 116 C631(0.44); C62(0.69); C166(0.70); C863(0.97)  LDD0630  [8]
 LDCM0314  AC51 HCT 116 C631(0.45); C663(0.86); C863(0.89); C596(0.98)  LDD0631  [8]
 LDCM0315  AC52 HCT 116 C631(0.52); C863(0.86); C62(0.87); C166(0.90)  LDD0632  [8]
 LDCM0316  AC53 HCT 116 C166(0.80); C863(0.86); C896(1.10); C663(1.11)  LDD0633  [8]
 LDCM0317  AC54 HCT 116 C631(0.60); C166(0.77); C863(0.89); C62(1.00)  LDD0634  [8]
 LDCM0318  AC55 HCT 116 C166(0.67); C863(0.73); C62(1.19); C896(1.34)  LDD0635  [8]
 LDCM0319  AC56 HCT 116 C166(0.62); C631(0.64); C62(0.78); C863(0.81)  LDD0636  [8]
 LDCM0320  AC57 HCT 116 C166(0.73); C62(0.81); C631(0.82); C663(1.20)  LDD0637  [8]
 LDCM0321  AC58 HCT 116 C62(0.62); C166(0.62); C631(0.89); C663(1.19)  LDD0638  [8]
 LDCM0322  AC59 HCT 116 C166(0.52); C62(0.88); C631(0.89); C663(1.28)  LDD0639  [8]
 LDCM0323  AC6 HCT 116 C166(0.68); C878(0.77); C62(0.79); C181(0.83)  LDD0640  [8]
 LDCM0324  AC60 HCT 116 C166(0.51); C631(0.78); C62(0.94); C663(1.26)  LDD0641  [8]
 LDCM0325  AC61 HCT 116 C166(0.65); C631(0.76); C62(0.80); C663(1.15)  LDD0642  [8]
 LDCM0326  AC62 HCT 116 C166(0.52); C631(0.71); C62(0.89); C663(1.40)  LDD0643  [8]
 LDCM0327  AC63 HCT 116 C166(0.55); C631(0.87); C62(1.08); C596(1.30)  LDD0644  [8]
 LDCM0328  AC64 HCT 116 C166(0.53); C631(0.75); C62(0.84); C663(1.37)  LDD0645  [8]
 LDCM0329  AC65 HCT 116 C166(0.57); C62(0.74); C631(0.87); C663(1.33)  LDD0646  [8]
 LDCM0330  AC66 HCT 116 C166(0.70); C631(0.85); C62(0.88); C596(1.25)  LDD0647  [8]
 LDCM0331  AC67 HCT 116 C166(0.39); C631(0.84); C62(0.86); C663(1.44)  LDD0648  [8]
 LDCM0332  AC68 HCT 116 C62(0.50); C166(0.77); C631(0.78); C896(0.92)  LDD0649  [8]
 LDCM0333  AC69 HCT 116 C631(0.70); C62(0.71); C166(0.76); C896(0.85)  LDD0650  [8]
 LDCM0334  AC7 HCT 116 C166(0.94); C181(0.95); C896(1.03); C631(1.07)  LDD0651  [8]
 LDCM0335  AC70 HCT 116 C62(0.39); C631(0.62); C166(0.74); C663(1.05)  LDD0652  [8]
 LDCM0336  AC71 HCT 116 C896(0.73); C62(0.85); C663(0.95); C166(0.97)  LDD0653  [8]
 LDCM0337  AC72 HCT 116 C62(0.47); C631(0.65); C166(0.98); C896(1.02)  LDD0654  [8]
 LDCM0338  AC73 HCT 116 C62(0.56); C631(0.69); C166(0.70); C896(1.04)  LDD0655  [8]
 LDCM0339  AC74 HCT 116 C166(0.69); C896(0.85); C62(0.96); C631(1.19)  LDD0656  [8]
 LDCM0340  AC75 HCT 116 C62(0.58); C166(0.71); C631(0.77); C896(1.02)  LDD0657  [8]
 LDCM0341  AC76 HCT 116 C166(0.80); C896(0.82); C62(0.85); C663(1.09)  LDD0658  [8]
 LDCM0342  AC77 HCT 116 C62(0.46); C166(0.60); C631(0.85); C896(1.01)  LDD0659  [8]
 LDCM0343  AC78 HCT 116 C62(0.63); C166(0.88); C631(0.89); C896(1.00)  LDD0660  [8]
 LDCM0344  AC79 HCT 116 C62(0.39); C631(0.63); C896(0.97); C166(1.00)  LDD0661  [8]
 LDCM0345  AC8 HCT 116 C166(0.75); C181(0.86); C878(0.88); C62(0.97)  LDD0662  [8]
 LDCM0346  AC80 HCT 116 C166(0.81); C896(0.83); C62(1.04); C663(1.04)  LDD0663  [8]
 LDCM0347  AC81 HCT 116 C62(0.43); C631(0.76); C896(0.96); C596(1.07)  LDD0664  [8]
 LDCM0348  AC82 HCT 116 C62(0.63); C166(0.68); C631(0.88); C896(0.91)  LDD0665  [8]
 LDCM0349  AC83 HCT 116 C166(0.39); C863(0.64); C62(0.72); C663(1.14)  LDD0666  [8]
 LDCM0350  AC84 HCT 116 C166(0.40); C863(0.64); C62(0.69); C663(1.08)  LDD0667  [8]
 LDCM0351  AC85 HCT 116 C166(0.53); C863(0.57); C62(1.02); C663(1.20)  LDD0668  [8]
 LDCM0352  AC86 HCT 116 C166(0.54); C62(0.66); C863(0.71); C663(1.06)  LDD0669  [8]
 LDCM0353  AC87 HCT 116 C62(0.55); C166(0.76); C863(0.83); C663(0.91)  LDD0670  [8]
 LDCM0354  AC88 HCT 116 C166(0.46); C62(0.47); C863(0.70); C663(1.13)  LDD0671  [8]
 LDCM0355  AC89 HCT 116 C166(0.38); C863(0.65); C62(0.66); C663(1.19)  LDD0672  [8]
 LDCM0357  AC90 HCT 116 C62(0.55); C596(0.93); C663(0.98); C863(1.13)  LDD0674  [8]
 LDCM0358  AC91 HCT 116 C166(0.41); C863(0.69); C663(1.04); C62(1.18)  LDD0675  [8]
 LDCM0359  AC92 HCT 116 C166(0.39); C863(0.67); C62(0.97); C663(1.19)  LDD0676  [8]
 LDCM0360  AC93 HCT 116 C166(0.53); C863(0.70); C62(0.74); C663(1.15)  LDD0677  [8]
 LDCM0361  AC94 HCT 116 C863(0.70); C166(0.72); C663(1.15); C596(1.19)  LDD0678  [8]
 LDCM0362  AC95 HCT 116 C62(0.48); C166(0.66); C863(0.72); C663(0.97)  LDD0679  [8]
 LDCM0363  AC96 HCT 116 C166(0.53); C863(0.64); C62(0.86); C896(1.13)  LDD0680  [8]
 LDCM0364  AC97 HCT 116 C166(0.34); C62(0.45); C863(0.66); C663(1.15)  LDD0681  [8]
 LDCM0365  AC98 HCT 116 C166(0.24); C863(0.37); C62(0.45); C631(0.70)  LDD0682  [8]
 LDCM0366  AC99 HCT 116 C166(0.47); C62(0.55); C863(0.56); C663(0.85)  LDD0683  [8]
 LDCM0248  AKOS034007472 HCT 116 C166(1.07); C181(0.96); C596(0.94); C62(1.96)  LDD0565  [8]
 LDCM0356  AKOS034007680 HCT 116 C181(0.93); C631(0.95); C896(1.03); C596(1.04)  LDD0673  [8]
 LDCM0275  AKOS034007705 HCT 116 C166(0.58); C181(0.62); C62(0.74); C878(0.81)  LDD0592  [8]
 LDCM0156  Aniline NCI-H1299 11.86  LDD0403  [1]
 LDCM0020  ARS-1620 HCC44 C596(1.02); C896(0.97); C663(0.96)  LDD0078  [8]
 LDCM0102  BDHI 8 Jurkat C896(4.97)  LDD0204  [23]
 LDCM0498  BS-3668 MDA-MB-231 C631(0.41)  LDD2091  [3]
 LDCM0630  CCW28-3 231MFP C596(1.62)  LDD2214  [24]
 LDCM0108  Chloroacetamide HeLa C863(0.00); C896(0.00); C878(0.00); C663(0.00)  LDD0222  [17]
 LDCM0632  CL-Sc Hep-G2 C863(2.37); C663(1.31); C596(1.29); C896(0.30)  LDD2227  [12]
 LDCM0367  CL1 HCT 116 C62(0.94); C663(0.96); C596(0.97); C896(1.00)  LDD0684  [8]
 LDCM0368  CL10 HCT 116 C166(0.75); C631(0.80); C863(0.90); C896(1.03)  LDD0685  [8]
 LDCM0369  CL100 HCT 116 C863(0.63); C166(1.05); C896(1.06); C631(1.07)  LDD0686  [8]
 LDCM0370  CL101 HCT 116 C166(0.77); C181(0.81); C896(0.84); C631(0.92)  LDD0687  [8]
 LDCM0371  CL102 HCT 116 C896(0.75); C631(0.79); C663(0.87); C166(0.89)  LDD0688  [8]
 LDCM0372  CL103 HCT 116 C896(0.80); C596(0.85); C663(0.88); C181(0.89)  LDD0689  [8]
 LDCM0373  CL104 HCT 116 C878(0.76); C663(0.85); C896(0.87); C181(0.93)  LDD0690  [8]
 LDCM0374  CL105 HCT 116 C166(0.51); C631(0.94); C896(1.05); C663(1.09)  LDD0691  [8]
 LDCM0375  CL106 HCT 116 C166(0.35); C631(0.97); C896(1.14); C663(1.29)  LDD0692  [8]
 LDCM0376  CL107 HCT 116 C166(0.43); C631(0.96); C896(1.17); C663(1.28)  LDD0693  [8]
 LDCM0377  CL108 HCT 116 C166(0.35); C896(0.87); C631(1.17); C663(1.22)  LDD0694  [8]
 LDCM0378  CL109 HCT 116 C166(0.60); C631(0.93); C663(1.11); C596(1.24)  LDD0695  [8]
 LDCM0379  CL11 HCT 116 C166(0.78); C631(0.88); C863(0.93); C62(0.97)  LDD0696  [8]
 LDCM0380  CL110 HCT 116 C166(0.43); C62(0.82); C631(1.02); C896(1.07)  LDD0697  [8]
 LDCM0381  CL111 HCT 116 C166(0.70); C631(0.79); C62(0.92); C663(1.12)  LDD0698  [8]
 LDCM0382  CL112 HCT 116 C166(0.81); C631(0.83); C181(0.94); C896(0.96)  LDD0699  [8]
 LDCM0383  CL113 HCT 116 C62(0.47); C166(0.50); C631(0.70); C181(0.77)  LDD0700  [8]
 LDCM0384  CL114 HCT 116 C62(0.38); C631(0.60); C166(0.65); C181(0.80)  LDD0701  [8]
 LDCM0385  CL115 HCT 116 C166(0.53); C62(0.60); C631(0.73); C181(0.86)  LDD0702  [8]
 LDCM0386  CL116 HCT 116 C166(0.54); C62(0.89); C181(0.91); C631(0.97)  LDD0703  [8]
 LDCM0387  CL117 HCT 116 C166(0.79); C181(0.81); C896(1.06); C631(1.07)  LDD0704  [8]
 LDCM0388  CL118 HCT 116 C181(0.87); C663(0.96); C166(0.99); C896(1.05)  LDD0705  [8]
 LDCM0389  CL119 HCT 116 C181(0.77); C166(0.87); C663(0.97); C631(1.05)  LDD0706  [8]
 LDCM0390  CL12 HCT 116 C166(0.81); C896(1.03); C863(1.10); C596(1.24)  LDD0707  [8]
 LDCM0391  CL120 HCT 116 C663(0.90); C181(0.96); C596(0.99); C166(1.01)  LDD0708  [8]
 LDCM0392  CL121 HCT 116 C631(0.58); C166(0.67); C62(0.70); C863(0.74)  LDD0709  [8]
 LDCM0393  CL122 HCT 116 C631(0.61); C166(0.65); C863(0.75); C62(0.87)  LDD0710  [8]
 LDCM0394  CL123 HCT 116 C631(0.57); C166(0.67); C863(0.78); C62(0.79)  LDD0711  [8]
 LDCM0395  CL124 HCT 116 C631(0.66); C166(0.66); C863(0.76); C62(0.77)  LDD0712  [8]
 LDCM0396  CL125 HCT 116 C631(0.94); C62(0.98); C166(1.07); C663(1.09)  LDD0713  [8]
 LDCM0397  CL126 HCT 116 C631(0.77); C166(0.97); C62(1.08); C663(1.09)  LDD0714  [8]
 LDCM0398  CL127 HCT 116 C166(0.79); C631(0.81); C62(0.90); C663(1.10)  LDD0715  [8]
 LDCM0399  CL128 HCT 116 C166(0.75); C62(0.75); C631(0.81); C663(1.13)  LDD0716  [8]
 LDCM0400  CL13 HCT 116 C166(0.86); C863(0.88); C896(0.97); C663(1.13)  LDD0717  [8]
 LDCM0401  CL14 HCT 116 C596(0.92); C631(0.97); C863(0.98); C896(1.00)  LDD0718  [8]
 LDCM0402  CL15 HCT 116 C166(0.83); C863(0.84); C896(0.95); C596(1.12)  LDD0719  [8]
 LDCM0403  CL16 HCT 116 C62(0.61); C166(0.67); C878(0.70); C631(0.76)  LDD0720  [8]
 LDCM0404  CL17 HCT 116 C863(0.80); C166(0.81); C181(0.82); C631(0.88)  LDD0721  [8]
 LDCM0405  CL18 HCT 116 C863(0.70); C166(0.74); C181(0.84); C596(0.89)  LDD0722  [8]
 LDCM0406  CL19 HCT 116 C863(0.68); C166(0.70); C181(0.82); C596(0.86)  LDD0723  [8]
 LDCM0407  CL2 HCT 116 C596(0.91); C663(0.99); C631(0.99); C896(1.11)  LDD0724  [8]
 LDCM0408  CL20 HCT 116 C166(0.61); C181(0.72); C62(0.75); C863(0.81)  LDD0725  [8]
 LDCM0409  CL21 HCT 116 C166(0.55); C181(0.68); C863(0.74); C62(0.85)  LDD0726  [8]
 LDCM0410  CL22 HCT 116 C166(0.55); C181(0.69); C62(0.89); C863(0.90)  LDD0727  [8]
 LDCM0411  CL23 HCT 116 C166(0.75); C62(0.77); C181(0.78); C863(0.84)  LDD0728  [8]
 LDCM0412  CL24 HCT 116 C166(0.60); C181(0.68); C62(0.78); C863(0.83)  LDD0729  [8]
 LDCM0413  CL25 HCT 116 C166(0.55); C181(0.69); C596(1.04); C62(0.66)  LDD0730  [8]
 LDCM0414  CL26 HCT 116 C166(0.57); C181(0.76); C596(1.32); C62(0.56)  LDD0731  [8]
 LDCM0415  CL27 HCT 116 C166(0.74); C181(0.87); C596(0.86); C62(0.99)  LDD0732  [8]
 LDCM0416  CL28 HCT 116 C166(0.58); C181(0.73); C596(0.98); C62(0.76)  LDD0733  [8]
 LDCM0417  CL29 HCT 116 C166(0.68); C181(0.74); C596(0.81); C62(1.24)  LDD0734  [8]
 LDCM0418  CL3 HCT 116 C166(0.95); C596(0.83); C62(1.09); C631(1.04)  LDD0735  [8]
 LDCM0419  CL30 HCT 116 C166(0.82); C181(0.82); C596(1.04); C62(0.97)  LDD0736  [8]
 LDCM0420  CL31 HCT 116 C166(0.84); C596(1.19); C62(0.53); C631(0.57)  LDD0737  [8]
 LDCM0421  CL32 HCT 116 C166(0.78); C596(1.46); C62(0.64); C631(0.77)  LDD0738  [8]
 LDCM0422  CL33 HCT 116 C166(0.76); C596(1.26); C62(0.54); C631(0.70)  LDD0739  [8]
 LDCM0423  CL34 HCT 116 C166(0.75); C596(1.67); C62(0.40); C631(0.88)  LDD0740  [8]
 LDCM0424  CL35 HCT 116 C166(0.78); C596(1.51); C62(0.38); C631(0.76)  LDD0741  [8]
 LDCM0425  CL36 HCT 116 C166(0.84); C596(1.55); C62(0.61); C631(0.80)  LDD0742  [8]
 LDCM0426  CL37 HCT 116 C166(0.77); C596(1.76); C62(0.41); C631(0.82)  LDD0743  [8]
 LDCM0428  CL39 HCT 116 C166(0.75); C596(1.57); C62(0.42); C631(1.00)  LDD0745  [8]
 LDCM0429  CL4 HCT 116 C166(0.92); C596(0.87); C62(1.34); C631(2.23)  LDD0746  [8]
 LDCM0430  CL40 HCT 116 C166(0.74); C596(1.61); C62(0.39); C631(0.71)  LDD0747  [8]
 LDCM0431  CL41 HCT 116 C166(0.85); C596(1.26); C62(0.45); C631(0.87)  LDD0748  [8]
 LDCM0432  CL42 HCT 116 C166(0.66); C596(3.14); C62(0.38); C631(0.85)  LDD0749  [8]
 LDCM0433  CL43 HCT 116 C166(0.81); C596(1.66); C62(0.44); C631(0.95)  LDD0750  [8]
 LDCM0434  CL44 HCT 116 C166(0.88); C596(1.57); C62(0.46); C631(0.97)  LDD0751  [8]
 LDCM0435  CL45 HCT 116 C166(0.77); C596(1.58); C62(0.48); C631(0.89)  LDD0752  [8]
 LDCM0436  CL46 HCT 116 C166(1.55); C181(1.29); C596(0.99); C62(1.25)  LDD0753  [8]
 LDCM0437  CL47 HCT 116 C166(1.63); C181(1.26); C596(0.97); C62(0.80)  LDD0754  [8]
 LDCM0438  CL48 HCT 116 C166(1.62); C181(1.63); C596(0.79); C62(1.22)  LDD0755  [8]
 LDCM0439  CL49 HCT 116 C166(1.50); C181(1.15); C596(1.00); C62(1.73)  LDD0756  [8]
 LDCM0440  CL5 HCT 116 C166(0.96); C596(0.86); C62(1.25); C631(0.96)  LDD0757  [8]
 LDCM0441  CL50 HCT 116 C166(1.58); C181(1.22); C596(0.96); C62(1.13)  LDD0758  [8]
 LDCM0442  CL51 HCT 116 C166(1.42); C181(1.27); C596(0.94); C62(1.40)  LDD0759  [8]
 LDCM0443  CL52 HCT 116 C166(1.36); C181(1.14); C596(1.09); C62(1.09)  LDD0760  [8]
 LDCM0444  CL53 HCT 116 C166(1.50); C181(1.11); C596(0.97); C62(0.67)  LDD0761  [8]
 LDCM0445  CL54 HCT 116 C166(1.62); C181(1.36); C596(0.87); C62(1.01)  LDD0762  [8]
 LDCM0446  CL55 HCT 116 C166(1.29); C181(1.19); C596(0.91); C62(1.06)  LDD0763  [8]
 LDCM0447  CL56 HCT 116 C166(1.18); C181(1.12); C596(1.03); C62(0.82)  LDD0764  [8]
 LDCM0448  CL57 HCT 116 C166(1.39); C181(1.29); C596(0.97); C62(0.83)  LDD0765  [8]
 LDCM0449  CL58 HCT 116 C166(1.59); C181(1.50); C596(0.91); C62(1.44)  LDD0766  [8]
 LDCM0450  CL59 HCT 116 C166(1.40); C181(1.52); C596(1.00); C62(1.02)  LDD0767  [8]
 LDCM0451  CL6 HCT 116 C166(0.88); C596(0.89); C62(1.02); C631(0.93)  LDD0768  [8]
 LDCM0452  CL60 HCT 116 C166(1.36); C181(1.11); C596(1.00); C62(1.21)  LDD0769  [8]
 LDCM0453  CL61 HCT 116 C166(0.86); C596(0.82); C62(0.91); C631(0.94)  LDD0770  [8]
 LDCM0454  CL62 HCT 116 C166(0.81); C596(0.84); C62(0.97); C631(1.04)  LDD0771  [8]
 LDCM0455  CL63 HCT 116 C166(0.67); C596(0.89); C62(0.74); C631(0.84)  LDD0772  [8]
 LDCM0456  CL64 HCT 116 C166(0.61); C596(0.81); C62(0.87); C631(0.93)  LDD0773  [8]
 LDCM0457  CL65 HCT 116 C166(0.86); C596(0.82); C62(0.96); C631(1.07)  LDD0774  [8]
 LDCM0458  CL66 HCT 116 C166(0.45); C596(0.81); C62(0.66); C631(0.99)  LDD0775  [8]
 LDCM0459  CL67 HCT 116 C166(0.51); C596(0.85); C62(0.68); C631(1.24)  LDD0776  [8]
 LDCM0460  CL68 HCT 116 C166(0.60); C596(0.94); C62(0.58); C631(0.98)  LDD0777  [8]
 LDCM0461  CL69 HCT 116 C166(0.99); C596(0.95); C62(1.10); C631(1.06)  LDD0778  [8]
 LDCM0462  CL7 HCT 116 C166(0.85); C596(1.01); C62(1.54); C631(1.46)  LDD0779  [8]
 LDCM0463  CL70 HCT 116 C166(0.69); C596(0.84); C62(0.74); C631(0.98)  LDD0780  [8]
 LDCM0464  CL71 HCT 116 C166(0.67); C596(0.85); C62(0.71); C631(0.91)  LDD0781  [8]
 LDCM0465  CL72 HCT 116 C166(0.88); C596(0.98); C62(0.91); C631(1.17)  LDD0782  [8]
 LDCM0466  CL73 HCT 116 C166(0.76); C596(0.91); C62(0.78); C631(1.02)  LDD0783  [8]
 LDCM0467  CL74 HCT 116 C166(0.61); C596(0.88); C62(0.71); C631(0.98)  LDD0784  [8]
 LDCM0469  CL76 HCT 116 C166(0.85); C181(0.98); C596(1.12); C62(0.99)  LDD0786  [8]
 LDCM0470  CL77 HCT 116 C166(1.10); C181(0.83); C596(1.57); C62(1.07)  LDD0787  [8]
 LDCM0471  CL78 HCT 116 C166(0.76); C181(0.92); C596(1.07); C62(0.81)  LDD0788  [8]
 LDCM0472  CL79 HCT 116 C166(0.54); C181(0.83); C596(1.14); C62(0.55)  LDD0789  [8]
 LDCM0473  CL8 HCT 116 C166(0.80); C596(1.55); C62(0.89); C631(0.64)  LDD0790  [8]
 LDCM0474  CL80 HCT 116 C166(0.97); C181(0.93); C596(0.86); C62(1.29)  LDD0791  [8]
 LDCM0475  CL81 HCT 116 C166(0.65); C181(0.92); C596(1.06); C62(0.73)  LDD0792  [8]
 LDCM0476  CL82 HCT 116 C166(0.47); C181(0.76); C596(1.59); C62(0.59)  LDD0793  [8]
 LDCM0477  CL83 HCT 116 C166(0.50); C181(0.90); C596(1.39); C62(0.55)  LDD0794  [8]
 LDCM0478  CL84 HCT 116 C166(0.49); C181(0.81); C596(1.34); C62(0.59)  LDD0795  [8]
 LDCM0479  CL85 HCT 116 C166(0.73); C181(1.03); C596(1.05); C62(0.79)  LDD0796  [8]
 LDCM0480  CL86 HCT 116 C166(1.03); C181(1.01); C596(1.18); C62(0.91)  LDD0797  [8]
 LDCM0481  CL87 HCT 116 C166(0.78); C181(0.92); C596(1.01); C62(0.89)  LDD0798  [8]
 LDCM0482  CL88 HCT 116 C166(0.56); C181(0.81); C596(1.18); C62(0.65)  LDD0799  [8]
 LDCM0483  CL89 HCT 116 C166(0.43); C181(0.76); C596(1.95); C62(0.54)  LDD0800  [8]
 LDCM0484  CL9 HCT 116 C166(0.85); C596(1.11); C62(1.09); C631(1.00)  LDD0801  [8]
 LDCM0485  CL90 HCT 116 C166(1.29); C181(1.13); C596(1.45); C62(1.15)  LDD0802  [8]
 LDCM0486  CL91 HCT 116 C166(0.73); C596(1.15); C62(0.85); C631(0.80)  LDD0803  [8]
 LDCM0487  CL92 HCT 116 C166(0.91); C596(1.22); C62(0.89); C631(0.72)  LDD0804  [8]
 LDCM0488  CL93 HCT 116 C166(1.04); C596(1.10); C62(1.11); C631(1.34)  LDD0805  [8]
 LDCM0489  CL94 HCT 116 C166(0.99); C596(1.32); C62(1.15); C631(1.39)  LDD0806  [8]
 LDCM0490  CL95 HCT 116 C166(0.70); C596(1.46); C62(0.71); C631(0.77)  LDD0807  [8]
 LDCM0491  CL96 HCT 116 C166(0.76); C596(1.23); C62(0.81); C631(0.92)  LDD0808  [8]
 LDCM0492  CL97 HCT 116 C166(0.77); C596(1.10); C62(0.72); C631(0.85)  LDD0809  [8]
 LDCM0493  CL98 HCT 116 C166(0.97); C596(1.08); C62(0.88); C631(0.93)  LDD0810  [8]
 LDCM0494  CL99 HCT 116 C166(1.15); C596(1.13); C62(1.05); C631(1.00)  LDD0811  [8]
 LDCM0191  Compound 21 HEK-293T 8.44  LDD0508  [21]
 LDCM0190  Compound 34 HEK-293T 6.70  LDD0510  [21]
 LDCM0192  Compound 35 HEK-293T 5.72  LDD0509  [21]
 LDCM0193  Compound 36 HEK-293T 5.31  LDD0511  [21]
 LDCM0634  CY-0357 Hep-G2 C596(0.38)  LDD2228  [12]
 LDCM0495  E2913 HEK-293T C878(0.96); C62(0.94); C316(1.06); C863(0.90)  LDD1698  [25]
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C631(8.58); C166(3.16); C596(2.66); C62(1.57)  LDD1702  [3]
 LDCM0625  F8 Ramos C896(1.27); C596(0.84); C631(0.92)  LDD2187  [26]
 LDCM0572  Fragment10 Ramos C896(1.17); C596(0.87); C631(0.76); C166(1.10)  LDD2189  [26]
 LDCM0573  Fragment11 Ramos C896(1.68); C596(15.50); C166(4.52)  LDD2190  [26]
 LDCM0574  Fragment12 Ramos C896(1.68); C596(0.54); C631(0.69); C166(0.70)  LDD2191  [26]
 LDCM0575  Fragment13 Ramos C896(0.86); C596(0.98); C631(0.80); C166(0.84)  LDD2192  [26]
 LDCM0576  Fragment14 Ramos C896(1.05); C596(0.70); C631(1.66)  LDD2193  [26]
 LDCM0579  Fragment20 Ramos C896(0.81); C596(0.63); C631(0.63); C166(0.81)  LDD2194  [26]
 LDCM0580  Fragment21 Ramos C896(0.99); C596(1.50); C631(0.92); C166(1.01)  LDD2195  [26]
 LDCM0582  Fragment23 Ramos C896(2.50); C596(0.89); C631(0.54); C166(0.58)  LDD2196  [26]
 LDCM0578  Fragment27 Ramos C896(0.87); C596(1.15); C631(0.84)  LDD2197  [26]
 LDCM0586  Fragment28 Ramos C896(0.61); C596(0.63); C631(0.86); C166(0.83)  LDD2198  [26]
 LDCM0588  Fragment30 Ramos C896(1.32); C596(1.36); C631(1.25); C166(1.01)  LDD2199  [26]
 LDCM0589  Fragment31 Ramos C896(0.92); C596(0.75); C631(0.98); C166(0.75)  LDD2200  [26]
 LDCM0590  Fragment32 Ramos C896(1.20); C596(1.98); C631(0.79); C166(0.60)  LDD2201  [26]
 LDCM0468  Fragment33 HCT 116 C166(0.56); C596(0.82); C62(0.72); C631(1.00)  LDD0785  [8]
 LDCM0596  Fragment38 Ramos C896(0.75); C596(1.00); C631(0.80); C166(1.40)  LDD2203  [26]
 LDCM0566  Fragment4 Ramos C896(0.91); C596(0.97); C631(1.45)  LDD2184  [26]
 LDCM0427  Fragment51 HCT 116 C166(0.72); C596(1.82); C62(0.39); C631(0.75)  LDD0744  [8]
 LDCM0610  Fragment52 Ramos C896(1.02); C596(0.97); C631(1.40); C166(0.95)  LDD2204  [26]
 LDCM0614  Fragment56 Ramos C896(1.12); C596(0.86); C631(1.16); C166(1.28)  LDD2205  [26]
 LDCM0569  Fragment7 Ramos C896(1.14); C596(0.60); C631(0.82)  LDD2186  [26]
 LDCM0571  Fragment9 Ramos C896(2.26); C596(1.21); C631(0.58); C166(0.96)  LDD2188  [26]
 LDCM0116  HHS-0101 DM93 Y805(0.38); Y397(0.86); Y729(1.83)  LDD0264  [6]
 LDCM0117  HHS-0201 DM93 Y805(0.60); Y729(0.78); Y397(0.79)  LDD0265  [6]
 LDCM0118  HHS-0301 DM93 Y805(0.72); Y729(0.79); Y397(0.84)  LDD0266  [6]
 LDCM0119  HHS-0401 DM93 Y805(0.58); Y397(0.83); Y729(0.83)  LDD0267  [6]
 LDCM0120  HHS-0701 DM93 Y729(0.76); Y805(0.80); Y397(0.83)  LDD0268  [6]
 LDCM0107  IAA HeLa N.A.  LDD0221  [17]
 LDCM0022  KB02 HCT 116 C596(1.80); C896(1.80); C663(1.42); C863(1.63)  LDD0080  [8]
 LDCM0023  KB03 HCT 116 C596(1.41); C896(1.20); C663(1.17); C863(1.58)  LDD0081  [8]
 LDCM0024  KB05 HCT 116 C596(1.92); C896(1.84); C663(1.42); C863(0.67)  LDD0082  [8]
 LDCM0500  Nucleophilic fragment 13a MDA-MB-231 C166(0.96)  LDD2093  [3]
 LDCM0503  Nucleophilic fragment 14b MDA-MB-231 C596(1.08)  LDD2096  [3]
 LDCM0505  Nucleophilic fragment 15b MDA-MB-231 C878(0.94)  LDD2098  [3]
 LDCM0506  Nucleophilic fragment 16a MDA-MB-231 C166(1.66); C631(0.73); C596(1.19); C878(0.89)  LDD2099  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C596(1.20)  LDD2107  [3]
 LDCM0516  Nucleophilic fragment 21a MDA-MB-231 C166(0.81); C631(0.58)  LDD2109  [3]
 LDCM0518  Nucleophilic fragment 22a MDA-MB-231 C596(0.92)  LDD2111  [3]
 LDCM0522  Nucleophilic fragment 24a MDA-MB-231 C631(1.24)  LDD2115  [3]
 LDCM0526  Nucleophilic fragment 26a MDA-MB-231 C166(2.23)  LDD2119  [3]
 LDCM0527  Nucleophilic fragment 26b MDA-MB-231 C596(1.16)  LDD2120  [3]
 LDCM0530  Nucleophilic fragment 28a MDA-MB-231 C896(1.03); C878(0.94)  LDD2123  [3]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C631(0.55); C596(0.83); C878(0.79)  LDD2125  [3]
 LDCM0534  Nucleophilic fragment 30a MDA-MB-231 C166(1.21); C631(0.93); C596(1.16); C878(0.72)  LDD2127  [3]
 LDCM0535  Nucleophilic fragment 30b MDA-MB-231 C596(1.14); C878(0.69)  LDD2128  [3]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C631(1.03)  LDD2135  [3]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C631(0.85); C596(1.14); C896(1.70)  LDD2136  [3]
 LDCM0544  Nucleophilic fragment 39 MDA-MB-231 C896(1.02)  LDD2137  [3]
 LDCM0211  Nucleophilic fragment 3b MDA-MB-231 C596(0.95)  LDD1700  [3]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C878(0.91)  LDD2140  [3]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C878(0.75)  LDD2146  [3]
 LDCM0627  NUDT7-COV-1 HEK-293T C596(0.60)  LDD2206  [27]
 LDCM0628  OTUB2-COV-1 HEK-293T C663(1.13); C863(0.83); C596(0.67)  LDD2207  [27]
 LDCM0131  RA190 MM1.R C596(1.60)  LDD0304  [28]
 LDCM0170  Structure8 Ramos 6.80  LDD0433  [29]
 LDCM0021  THZ1 HCT 116 C896(1.01); C596(1.01); C166(1.15); C663(1.06)  LDD2173  [8]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein O-GlcNAcase (OGA) Glycosyl hydrolase 84 family O60502

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Streptozocin Small molecular drug DB00428
Phase 1
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mk-8719 Small molecular drug DP6Y5N
Mk 8719 . D03HDL

References

1 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
2 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
3 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
4 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.
5 Chemoproteomic capture of RNA binding activity in living cells. Nat Commun. 2023 Oct 7;14(1):6282. doi: 10.1038/s41467-023-41844-z.
Mass spectrometry data entry: PXD044625
6 Discovery of a Cell-Active SuTEx Ligand of Prostaglandin Reductase 2. Chembiochem. 2021 Jun 15;22(12):2134-2139. doi: 10.1002/cbic.202000879. Epub 2021 Apr 29.
7 Global targeting of functional tyrosines using sulfur-triazole exchange chemistry. Nat Chem Biol. 2020 Feb;16(2):150-159. doi: 10.1038/s41589-019-0404-5. Epub 2019 Nov 25.
8 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
9 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
10 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
11 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
12 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
13 A modification-centric assessment tool for the performance of chemoproteomic probes. Nat Chem Biol. 2022 Aug;18(8):904-912. doi: 10.1038/s41589-022-01074-8. Epub 2022 Jul 21.
Mass spectrometry data entry: PXD027758 , PXD027755 , PXD027760 , PXD027762 , PXD027756 , PXD027591 , PXD007149 , PXD030064 , PXD032392 , PXD027789 , PXD027767 , PXD027764
14 Multiplexed CuAAC Suzuki-Miyaura Labeling for Tandem Activity-Based Chemoproteomic Profiling. Anal Chem. 2021 Feb 2;93(4):2610-2618. doi: 10.1021/acs.analchem.0c04726. Epub 2021 Jan 20.
Mass spectrometry data entry: PXD022279
15 Oxidative cyclization reagents reveal tryptophan cation- interactions. Nature. 2024 Mar;627(8004):680-687. doi: 10.1038/s41586-024-07140-6. Epub 2024 Mar 6.
Mass spectrometry data entry: PXD001377 , PXD005252
16 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.
17 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
18 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
19 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
20 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
21 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
22 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570
23 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
24 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.
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Mass spectrometry data entry: PXD044402
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