Details of the Probe-central Interaction Altas

General Information of Experiment

Probe Name C387  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 37 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05758  S-methyl-5'-thioadenosine phosphorylase (MTAP) 27.5
 LDTP16007  Lipid droplet-associated hydrolase (LDAH) 25.3
 LDTP01769  Dihydrofolate reductase (DHFR) 21.1
 LDTP12628  Palmitoyl-protein thioesterase ABHD10, mitochondrial (ABHD10) 17.9
 LDTP00907  Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta (PDE6D) 15.2
 LDTP03692  Bifunctional epoxide hydrolase 2 (EPHX2) 12.2
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 12.0
 LDTP10182  TLC domain-containing protein 1 (TLCD1) 11.4
 LDTP04285  Proteasome subunit beta type-2 (PSMB2) 10.1
 LDTP02505  Lysosomal protective protein (CTSA) 10.1
 LDTP08476  5'-3' exonuclease PLD3 (PLD3) 9.6
 LDTP16032  Retinoid-inducible serine carboxypeptidase (SCPEP1) 9.6
 LDTP03060  Proteasome subunit beta type-1 (PSMB1) 9.4
 LDTP00428  Tripeptidyl-peptidase 1 (TPP1) 9.0
 LDTP06511  Electron transfer flavoprotein-ubiquinone oxidoreductase, mitochondrial (ETFDH) 8.8
 LDTP04004  Lysosomal Pro-X carboxypeptidase (PRCP) 8.8
 LDTP03418  Proteasome subunit beta type-6 (PSMB6) 8.6
 LDTP02359  Heme oxygenase 1 (HMOX1) 8.5
 LDTP04388  Palmitoyl-protein thioesterase 1 (PPT1) 8.5
 LDTP02896  Sphingomyelin phosphodiesterase (SMPD1) 8.0
 LDTP06375  Delta(24)-sterol reductase (DHCR24) 7.6
 LDTP06477  Methylsterol monooxygenase 1 (MSMO1) 7.1
 LDTP05905  Acid ceramidase (ASAH1) 7.0
 LDTP12610  Obg-like ATPase 1 (OLA1) 7.0
 LDTP03394  Ceramide synthase 1 (CERS1) 6.9
 LDTP03417  Proteasome subunit beta type-4 (PSMB4) 6.2
 LDTP01982  NADH-ubiquinone oxidoreductase chain 1 (MT-ND1) 6.2
 LDTP00273  Dynamin-1-like protein (DNM1L) 6.0
 LDTP04284  Proteasome subunit beta type-3 (PSMB3) 5.7
 LDTP05476  3-ketodihydrosphingosine reductase (KDSR) 5.7
 LDTP02175  Epoxide hydrolase 1 (EPHX1) 5.4
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.4
 LDTP13620  Lysosomal thioesterase PPT2 (PPT2) 5.4
 LDTP00988  Protein O-GlcNAcase (OGA) 5.3
 LDTP15988  Probable serine carboxypeptidase CPVL (CPVL) 5.2
 LDTP10188  FAD-dependent oxidoreductase domain-containing protein 1 (FOXRED1) 5.1
 LDTP15480  Prenylcysteine oxidase-like (PCYOX1L) 5.1
Transporter and channel
Click to Show/Hide to Show 16 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 14.2
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 13.5
 LDTP04071  Voltage-dependent anion-selective channel protein 2 (VDAC2) 11.6
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 10.8
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 10.4
 LDTP00630  Importin-8 (IPO8) 8.1
 LDTP07236  Protein GPR107 (GPR107) 7.7
 LDTP08881  Transmembrane protein 199 (TMEM199) 7.2
 LDTP06034  Lysosome membrane protein 2 (SCARB2) 6.6
 LDTP18153  Major facilitator superfamily domain-containing protein 3 (MFSD3) 6.5
 LDTP15733  Solute carrier family 25 member 44 (SLC25A44) 5.5
 LDTP00865  Mitochondrial carnitine/acylcarnitine carrier protein (SLC25A20) 5.3
 LDTP06426  Translocating chain-associated membrane protein 1 (TRAM1) 5.2
 LDTP00970  Gasdermin-E (GSDME) 5.0
 LDTP02215  Prosaposin (PSAP) 5.0
 LDTP09547  Scavenger receptor class B member 1 (SCARB1) 5.0
Immunoglobulin
Click to Show/Hide to Show 1 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP04720  IgG receptor FcRn large subunit p51 (FCGRT) 5.0
Other
Click to Show/Hide to Show 21 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP16099  p53 and DNA damage-regulated protein 1 (PDRG1) 38.6
 LDTP05160  Nucleobindin-2 (NUCB2) 18.8
 LDTP07476  RAD50-interacting protein 1 (RINT1) 10.9
 LDTP04094  Large proline-rich protein BAG6 (BAG6) 9.7
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 9.7
 LDTP00871  Microtubule nucleation factor SSNA1 (SSNA1) 8.8
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 8.3
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 8.2
 LDTP15623  Neuferricin (CYB5D2) 8.0
 LDTP13828  Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) 7.0
 LDTP05375  Nucleobindin-1 (NUCB1) 6.8
 LDTP11076  Apolipoprotein L2 (APOL2) 6.4
 LDTP12468  Diablo IAP-binding mitochondrial protein (DIABLO) 6.3
 LDTP07839  Capping protein-inhibiting regulator of actin dynamics (CRACD) 6.3
 LDTP13755  Brain-specific angiogenesis inhibitor 1-associated protein 2 (BAIAP2) 5.8
 LDTP14263  TAF6-like RNA polymerase II p300/CBP-associated factor-associated factor 65 kDa subunit 6L (TAF6L) 5.5
 LDTP04652  Eukaryotic translation initiation factor 5 (EIF5) 5.5
 LDTP14458  Tetraspanin-6 (TSPAN6) 5.4
 LDTP14939  Membralin (TMEM259) 5.3
 LDTP08364  Ankyrin repeat and LEM domain-containing protein 2 (ANKLE2) 5.1
 LDTP12642  CYFIP-related Rac1 interactor B (CYRIB) 5.0

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587