Details of the Target

General Information of Target

Target ID	LDTP01059
Target Name	Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B)
Gene Name	TIMM17B
Gene ID	10245
Synonyms	TIM17B; Mitochondrial import inner membrane translocase subunit Tim17-B
3D Structure	Download 2D Sequence (FASTA) Download 3D Structure (PDB) Download
Sequence	MEEYAREPCPWRIVDDCGGAFTMGVIGGGVFQAIKGFRNAPVGIRHRLRGSANAVRIRAP QIGGSFAVWGGLFSTIDCGLVRLRGKEDPWNSITSGALTGAVLAARSGPLAMVGSAMMGG ILLALIEGVGILLTRYTAQQFRNAPPFLEDPSQLPPKDGTPAPGYPSYQQYH
Target Bioclass	Transporter and channel
Family	Tim17/Tim22/Tim23 family
Subcellular location	Mitochondrion inner membrane
Function	Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.
Uniprot ID	O60830
Ensemble ID	ENST00000376582.7
HGNC ID	HGNC:17310

Probe(s) Labeling This Target

ABPP Probe

Click To Hide/Show 9 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
FBPP2 Probe Info	9.59	LDD0324	[1]
P11 Probe Info	14.68	LDD0201	[2]
DBIA Probe Info	C17(2.67)	LDD3427	[3]
Acrolein Probe Info	N.A.	LDD0227	[4]
IA-alkyne Probe Info	C78(0.00); C9(0.00)	LDD0165	[5]
TFBX Probe Info	N.A.	LDD0027	[6]
IPM Probe Info	N.A.	LDD2156	[7]
Phosphinate-6 Probe Info	N.A.	LDD0018	[8]
NAIA_5 Probe Info	N.A.	LDD2223	[9]

PAL-AfBPP Probe

Click To Hide/Show 226 Probe Related to This Target

Probe name	Binding Site(Ratio)	Interaction ID	Ref
ILS-1 PP Probe Info	4.99	LDD0417	[10]
C003 Probe Info	13.36	LDD1713	[11]
C004 Probe Info	17.51	LDD1714	[11]
C007 Probe Info	9.13	LDD1716	[11]
C008 Probe Info	9.71	LDD1717	[11]
C010 Probe Info	7.41	LDD1719	[11]
C011 Probe Info	27.67	LDD1720	[11]
C017 Probe Info	53.82	LDD1725	[11]
C018 Probe Info	8.06	LDD1726	[11]
C022 Probe Info	69.55	LDD1728	[11]
C026 Probe Info	73.52	LDD1732	[11]
C027 Probe Info	22.32	LDD1733	[11]
C039 Probe Info	12.38	LDD1739	[11]
C040 Probe Info	63.12	LDD1740	[11]
C041 Probe Info	33.36	LDD1741	[11]
C044 Probe Info	5.03	LDD1743	[11]
C049 Probe Info	24.93	LDD1747	[11]
C051 Probe Info	13.64	LDD1749	[11]
C052 Probe Info	10.41	LDD1750	[11]
C053 Probe Info	11.08	LDD1751	[11]
C055 Probe Info	99.73	LDD1752	[11]
C056 Probe Info	99.73	LDD1753	[11]
C059 Probe Info	19.29	LDD1756	[11]
C060 Probe Info	8.69	LDD1757	[11]
C063 Probe Info	34.54	LDD1760	[11]
C064 Probe Info	26.72	LDD1761	[11]
C067 Probe Info	14.93	LDD1763	[11]
C068 Probe Info	6.15	LDD1764	[11]
C070 Probe Info	59.30	LDD1766	[11]
C071 Probe Info	13.64	LDD1767	[11]
C072 Probe Info	32.90	LDD1768	[11]
C075 Probe Info	9.06	LDD1770	[11]
C082 Probe Info	22.32	LDD1774	[11]
C083 Probe Info	5.78	LDD1775	[11]
C085 Probe Info	12.55	LDD1777	[11]
C087 Probe Info	25.11	LDD1779	[11]
C095 Probe Info	31.56	LDD1786	[11]
C098 Probe Info	16.22	LDD1787	[11]
C099 Probe Info	17.15	LDD1788	[11]
C100 Probe Info	34.78	LDD1789	[11]
C102 Probe Info	21.86	LDD1790	[11]
C105 Probe Info	9.32	LDD1792	[11]
C106 Probe Info	99.73	LDD1793	[11]
C107 Probe Info	99.73	LDD1794	[11]
C108 Probe Info	99.73	LDD1795	[11]
C110 Probe Info	6.82	LDD1797	[11]
C112 Probe Info	99.73	LDD1799	[11]
C117 Probe Info	6.63	LDD1804	[11]
C120 Probe Info	6.23	LDD1806	[11]
C122 Probe Info	8.11	LDD1808	[11]
C129 Probe Info	36.50	LDD1811	[11]
C130 Probe Info	53.82	LDD1812	[11]
C131 Probe Info	5.35	LDD1813	[11]
C134 Probe Info	99.73	LDD1816	[11]
C135 Probe Info	56.89	LDD1817	[11]
C139 Probe Info	48.84	LDD1821	[11]
C140 Probe Info	44.94	LDD1822	[11]
C141 Probe Info	50.91	LDD1823	[11]
C143 Probe Info	43.41	LDD1825	[11]
C145 Probe Info	20.82	LDD1827	[11]
C147 Probe Info	16.91	LDD1829	[11]
C153 Probe Info	99.73	LDD1834	[11]
C156 Probe Info	23.43	LDD1836	[11]
C158 Probe Info	17.88	LDD1838	[11]
C159 Probe Info	99.73	LDD1839	[11]
C160 Probe Info	99.73	LDD1840	[11]
C161 Probe Info	99.73	LDD1841	[11]
C163 Probe Info	22.32	LDD1843	[11]
C164 Probe Info	9.85	LDD1844	[11]
C165 Probe Info	50.56	LDD1845	[11]
C166 Probe Info	25.28	LDD1846	[11]
C176 Probe Info	8.63	LDD1855	[11]
C177 Probe Info	27.67	LDD1856	[11]
C178 Probe Info	99.73	LDD1857	[11]
C182 Probe Info	24.42	LDD1860	[11]
C183 Probe Info	31.34	LDD1861	[11]
C185 Probe Info	10.06	LDD1863	[11]
C186 Probe Info	50.91	LDD1864	[11]
C187 Probe Info	99.73	LDD1865	[11]
C191 Probe Info	20.82	LDD1868	[11]
C193 Probe Info	25.81	LDD1869	[11]
C194 Probe Info	36.76	LDD1870	[11]
C196 Probe Info	31.56	LDD1872	[11]
C197 Probe Info	11.47	LDD1873	[11]
C198 Probe Info	65.34	LDD1874	[11]
C199 Probe Info	6.15	LDD1875	[11]
C201 Probe Info	99.73	LDD1877	[11]
C204 Probe Info	18.13	LDD1879	[11]
C205 Probe Info	9.71	LDD1880	[11]
C206 Probe Info	99.73	LDD1881	[11]
C207 Probe Info	85.63	LDD1882	[11]
C215 Probe Info	8.82	LDD1889	[11]
C216 Probe Info	16.56	LDD1890	[11]
C217 Probe Info	17.88	LDD1891	[11]
C218 Probe Info	99.73	LDD1892	[11]
C219 Probe Info	56.10	LDD1893	[11]
C220 Probe Info	99.73	LDD1894	[11]
C222 Probe Info	32.67	LDD1896	[11]
C223 Probe Info	22.63	LDD1897	[11]
C225 Probe Info	99.73	LDD1898	[11]
C226 Probe Info	99.73	LDD1899	[11]
C228 Probe Info	99.73	LDD1901	[11]
C229 Probe Info	16.68	LDD1902	[11]
C231 Probe Info	52.71	LDD1904	[11]
C232 Probe Info	62.68	LDD1905	[11]
C233 Probe Info	33.59	LDD1906	[11]
C234 Probe Info	37.79	LDD1907	[11]
C235 Probe Info	76.64	LDD1908	[11]
C238 Probe Info	64.89	LDD1911	[11]
C239 Probe Info	8.82	LDD1912	[11]
C240 Probe Info	30.48	LDD1913	[11]
C243 Probe Info	42.22	LDD1916	[11]
C244 Probe Info	26.72	LDD1917	[11]
C245 Probe Info	18.25	LDD1918	[11]
C246 Probe Info	38.85	LDD1919	[11]
C249 Probe Info	25.46	LDD1922	[11]
C252 Probe Info	39.67	LDD1925	[11]
C255 Probe Info	5.70	LDD1928	[11]
C258 Probe Info	18.90	LDD1931	[11]
C260 Probe Info	6.63	LDD1932	[11]
C261 Probe Info	4.99	LDD1933	[11]
C264 Probe Info	86.22	LDD1935	[11]
C265 Probe Info	61.82	LDD1936	[11]
C266 Probe Info	17.75	LDD1937	[11]
C269 Probe Info	10.78	LDD1939	[11]
C270 Probe Info	38.05	LDD1940	[11]
C271 Probe Info	7.67	LDD1941	[11]
C272 Probe Info	6.36	LDD1942	[11]
C273 Probe Info	15.45	LDD1943	[11]
C274 Probe Info	6.15	LDD1944	[11]
C277 Probe Info	34.06	LDD1947	[11]
C278 Probe Info	99.73	LDD1948	[11]
C282 Probe Info	71.01	LDD1952	[11]
C284 Probe Info	79.89	LDD1954	[11]
C285 Probe Info	53.08	LDD1955	[11]
C286 Probe Info	10.06	LDD1956	[11]
C287 Probe Info	49.52	LDD1957	[11]
C288 Probe Info	20.53	LDD1958	[11]
C289 Probe Info	60.13	LDD1959	[11]
C290 Probe Info	20.97	LDD1960	[11]
C292 Probe Info	17.03	LDD1962	[11]
C293 Probe Info	81.01	LDD1963	[11]
C294 Probe Info	9.78	LDD1964	[11]
C296 Probe Info	70.03	LDD1966	[11]
C297 Probe Info	12.82	LDD1967	[11]
C299 Probe Info	94.35	LDD1968	[11]
C300 Probe Info	6.50	LDD1969	[11]
C301 Probe Info	15.24	LDD1970	[11]
C303 Probe Info	16.80	LDD1972	[11]
C304 Probe Info	30.06	LDD1973	[11]
C305 Probe Info	62.25	LDD1974	[11]
C307 Probe Info	15.56	LDD1975	[11]
C310 Probe Info	46.53	LDD1977	[11]
C311 Probe Info	5.54	LDD1978	[11]
C313 Probe Info	75.06	LDD1980	[11]
C314 Probe Info	87.43	LDD1981	[11]
C317 Probe Info	20.25	LDD1983	[11]
C320 Probe Info	19.70	LDD1986	[11]
C322 Probe Info	60.55	LDD1988	[11]
C326 Probe Info	74.03	LDD1990	[11]
C327 Probe Info	33.82	LDD1991	[11]
C328 Probe Info	6.73	LDD1992	[11]
C332 Probe Info	4.96	LDD1995	[11]
C333 Probe Info	33.13	LDD1996	[11]
C335 Probe Info	4.99	LDD1998	[11]
C337 Probe Info	21.11	LDD2000	[11]
C338 Probe Info	99.73	LDD2001	[11]
C339 Probe Info	99.73	LDD2002	[11]
C340 Probe Info	12.21	LDD2003	[11]
C348 Probe Info	37.01	LDD2009	[11]
C349 Probe Info	39.67	LDD2010	[11]
C350 Probe Info	64.00	LDD2011	[11]
C353 Probe Info	8.51	LDD2014	[11]
C354 Probe Info	10.41	LDD2015	[11]
C355 Probe Info	99.73	LDD2016	[11]
C356 Probe Info	99.73	LDD2017	[11]
C357 Probe Info	66.72	LDD2018	[11]
C360 Probe Info	22.94	LDD2021	[11]
C361 Probe Info	63.12	LDD2022	[11]
C362 Probe Info	97.68	LDD2023	[11]
C363 Probe Info	60.97	LDD2024	[11]
C364 Probe Info	57.68	LDD2025	[11]
C366 Probe Info	54.19	LDD2027	[11]
C367 Probe Info	8.51	LDD2028	[11]
C369 Probe Info	5.86	LDD2030	[11]
C373 Probe Info	24.93	LDD2033	[11]
C376 Probe Info	33.13	LDD2036	[11]
C378 Probe Info	26.54	LDD2037	[11]
C380 Probe Info	25.99	LDD2039	[11]
C382 Probe Info	88.65	LDD2041	[11]
C383 Probe Info	99.73	LDD2042	[11]
C385 Probe Info	7.67	LDD2044	[11]
C386 Probe Info	44.32	LDD2045	[11]
C387 Probe Info	10.78	LDD2046	[11]
C388 Probe Info	99.73	LDD2047	[11]
C389 Probe Info	13.93	LDD2048	[11]
C390 Probe Info	99.73	LDD2049	[11]
C391 Probe Info	47.84	LDD2050	[11]
C396 Probe Info	21.41	LDD2055	[11]
C397 Probe Info	69.07	LDD2056	[11]
C399 Probe Info	99.73	LDD2058	[11]
C400 Probe Info	16.22	LDD2059	[11]
C403 Probe Info	99.73	LDD2061	[11]
C424 Probe Info	53.82	LDD2079	[11]
C426 Probe Info	99.73	LDD2081	[11]
C428 Probe Info	16.00	LDD2083	[11]
C429 Probe Info	99.73	LDD2084	[11]
C430 Probe Info	29.86	LDD2085	[11]
C431 Probe Info	99.73	LDD2086	[11]
C432 Probe Info	5.10	LDD2087	[11]
C433 Probe Info	15.56	LDD2088	[11]
FFF probe11 Probe Info	20.00	LDD0471	[12]
FFF probe12 Probe Info	20.00	LDD0473	[12]
FFF probe13 Probe Info	20.00	LDD0475	[12]
FFF probe14 Probe Info	20.00	LDD0477	[12]
FFF probe15 Probe Info	20.00	LDD0478	[12]
FFF probe2 Probe Info	20.00	LDD0463	[12]
FFF probe3 Probe Info	20.00	LDD0464	[12]
FFF probe4 Probe Info	20.00	LDD0466	[12]
FFF probe6 Probe Info	20.00	LDD0467	[12]
FFF probe9 Probe Info	20.00	LDD0470	[12]
JN0003 Probe Info	20.00	LDD0469	[12]
A-DA Probe Info	20.00	LDD0145	[13]
BD-F Probe Info	D16(0.00); D15(0.00); G19(0.00)	LDD0024	[14]
LD-F Probe Info	A20(0.00); G18(0.00); D16(0.00)	LDD0015	[14]
OEA-DA Probe Info	20.00	LDD0046	[15]

Competitor(s) Related to This Target

Competitor ID	Name	Cell line	Binding Site(Ratio)	Interaction ID	Ref
LDCM0214	AC1	HEK-293T	C78(1.20)	LDD1507	[16]
LDCM0215	AC10	HEK-293T	C17(0.94); C78(1.02)	LDD1508	[16]
LDCM0226	AC11	HEK-293T	C17(1.02); C78(0.92)	LDD1509	[16]
LDCM0237	AC12	HEK-293T	C17(1.05); C78(0.99)	LDD1510	[16]
LDCM0259	AC14	HEK-293T	C17(1.00); C78(1.00)	LDD1512	[16]
LDCM0270	AC15	HEK-293T	C17(1.00); C78(0.95)	LDD1513	[16]
LDCM0276	AC17	HEK-293T	C78(1.14)	LDD1515	[16]
LDCM0277	AC18	HEK-293T	C17(1.00); C78(0.99)	LDD1516	[16]
LDCM0278	AC19	HEK-293T	C17(1.03); C78(0.86)	LDD1517	[16]
LDCM0279	AC2	HEK-293T	C17(1.03); C78(0.94)	LDD1518	[16]
LDCM0280	AC20	HEK-293T	C17(1.13); C78(0.96)	LDD1519	[16]
LDCM0281	AC21	HEK-293T	C17(1.04); C78(1.05)	LDD1520	[16]
LDCM0282	AC22	HEK-293T	C17(0.91); C78(0.94)	LDD1521	[16]
LDCM0283	AC23	HEK-293T	C17(1.11); C78(1.04)	LDD1522	[16]
LDCM0284	AC24	HEK-293T	C78(1.10)	LDD1523	[16]
LDCM0285	AC25	HEK-293T	C78(1.14)	LDD1524	[16]
LDCM0286	AC26	HEK-293T	C17(1.02); C78(1.10)	LDD1525	[16]
LDCM0287	AC27	HEK-293T	C17(1.07); C78(0.92)	LDD1526	[16]
LDCM0288	AC28	HEK-293T	C17(1.17); C78(0.99)	LDD1527	[16]
LDCM0289	AC29	HEK-293T	C17(1.02); C78(0.94)	LDD1528	[16]
LDCM0290	AC3	HEK-293T	C17(1.00); C78(0.89)	LDD1529	[16]
LDCM0291	AC30	HEK-293T	C17(1.07); C78(0.91)	LDD1530	[16]
LDCM0292	AC31	HEK-293T	C17(1.00); C78(1.06)	LDD1531	[16]
LDCM0293	AC32	HEK-293T	C78(1.11)	LDD1532	[16]
LDCM0294	AC33	HEK-293T	C78(0.97)	LDD1533	[16]
LDCM0295	AC34	HEK-293T	C17(0.95); C78(1.07)	LDD1534	[16]
LDCM0296	AC35	HEK-293T	C17(0.96); C78(1.02)	LDD1535	[16]
LDCM0297	AC36	HEK-293T	C17(1.22); C78(1.11)	LDD1536	[16]
LDCM0298	AC37	HEK-293T	C17(1.04); C78(0.99)	LDD1537	[16]
LDCM0299	AC38	HEK-293T	C17(0.99); C78(1.08)	LDD1538	[16]
LDCM0300	AC39	HEK-293T	C17(0.95); C78(1.21)	LDD1539	[16]
LDCM0301	AC4	HEK-293T	C17(1.19); C78(1.10)	LDD1540	[16]
LDCM0302	AC40	HEK-293T	C78(1.18)	LDD1541	[16]
LDCM0303	AC41	HEK-293T	C78(1.10)	LDD1542	[16]
LDCM0304	AC42	HEK-293T	C17(0.92); C78(1.20)	LDD1543	[16]
LDCM0305	AC43	HEK-293T	C17(0.98); C78(0.94)	LDD1544	[16]
LDCM0306	AC44	HEK-293T	C17(1.05); C78(1.04)	LDD1545	[16]
LDCM0307	AC45	HEK-293T	C17(0.96); C78(0.88)	LDD1546	[16]
LDCM0308	AC46	HEK-293T	C17(0.95); C78(0.97)	LDD1547	[16]
LDCM0309	AC47	HEK-293T	C17(0.97); C78(1.02)	LDD1548	[16]
LDCM0310	AC48	HEK-293T	C78(1.13)	LDD1549	[16]
LDCM0311	AC49	HEK-293T	C78(0.96)	LDD1550	[16]
LDCM0312	AC5	HEK-293T	C17(1.02); C78(0.89)	LDD1551	[16]
LDCM0313	AC50	HEK-293T	C17(1.02); C78(1.00)	LDD1552	[16]
LDCM0314	AC51	HEK-293T	C17(1.08); C78(0.90)	LDD1553	[16]
LDCM0315	AC52	HEK-293T	C17(1.17); C78(0.93)	LDD1554	[16]
LDCM0316	AC53	HEK-293T	C17(0.90); C78(0.90)	LDD1555	[16]
LDCM0317	AC54	HEK-293T	C17(1.17); C78(1.00)	LDD1556	[16]
LDCM0318	AC55	HEK-293T	C17(0.96); C78(0.97)	LDD1557	[16]
LDCM0319	AC56	HEK-293T	C78(0.99)	LDD1558	[16]
LDCM0320	AC57	HEK-293T	C78(1.13)	LDD1559	[16]
LDCM0321	AC58	HEK-293T	C17(1.05); C78(1.07)	LDD1560	[16]
LDCM0322	AC59	HEK-293T	C17(1.08); C78(1.05)	LDD1561	[16]
LDCM0323	AC6	HEK-293T	C17(1.01); C78(1.08)	LDD1562	[16]
LDCM0324	AC60	HEK-293T	C17(1.08); C78(0.96)	LDD1563	[16]
LDCM0325	AC61	HEK-293T	C17(1.04); C78(1.03)	LDD1564	[16]
LDCM0326	AC62	HEK-293T	C17(0.89); C78(0.95)	LDD1565	[16]
LDCM0327	AC63	HEK-293T	C17(1.04); C78(0.92)	LDD1566	[16]
LDCM0328	AC64	HEK-293T	C78(1.05)	LDD1567	[16]
LDCM0334	AC7	HEK-293T	C17(0.94); C78(0.97)	LDD1568	[16]
LDCM0345	AC8	HEK-293T	C78(1.02)	LDD1569	[16]
LDCM0248	AKOS034007472	HEK-293T	C17(0.90); C78(0.87)	LDD1511	[16]
LDCM0356	AKOS034007680	HEK-293T	C78(1.06)	LDD1570	[16]
LDCM0275	AKOS034007705	HEK-293T	C78(0.99)	LDD1514	[16]
LDCM0088	C45	HEK-293T	14.68	LDD0201	[2]
LDCM0367	CL1	HEK-293T	C17(1.13); C78(1.00)	LDD1571	[16]
LDCM0368	CL10	HEK-293T	C17(0.70); C78(0.96)	LDD1572	[16]
LDCM0369	CL100	HEK-293T	C17(1.00); C78(0.94)	LDD1573	[16]
LDCM0370	CL101	HEK-293T	C17(0.95); C78(1.06)	LDD1574	[16]
LDCM0371	CL102	HEK-293T	C17(0.99); C78(1.08)	LDD1575	[16]
LDCM0372	CL103	HEK-293T	C17(0.91); C78(1.17)	LDD1576	[16]
LDCM0373	CL104	HEK-293T	C17(1.00); C78(0.95)	LDD1577	[16]
LDCM0374	CL105	HEK-293T	C17(1.09); C78(1.07)	LDD1578	[16]
LDCM0375	CL106	HEK-293T	C17(1.01); C78(1.13)	LDD1579	[16]
LDCM0376	CL107	HEK-293T	C17(1.15); C78(1.01)	LDD1580	[16]
LDCM0377	CL108	HEK-293T	C17(1.00); C78(1.00)	LDD1581	[16]
LDCM0378	CL109	HEK-293T	C17(1.04); C78(1.09)	LDD1582	[16]
LDCM0379	CL11	HEK-293T	C17(1.11); C78(1.15)	LDD1583	[16]
LDCM0380	CL110	HEK-293T	C17(1.10); C78(1.01)	LDD1584	[16]
LDCM0381	CL111	HEK-293T	C17(0.94); C78(1.16)	LDD1585	[16]
LDCM0382	CL112	HEK-293T	C17(1.05); C78(1.04)	LDD1586	[16]
LDCM0383	CL113	HEK-293T	C17(1.16); C78(1.08)	LDD1587	[16]
LDCM0384	CL114	HEK-293T	C17(0.99); C78(1.14)	LDD1588	[16]
LDCM0385	CL115	HEK-293T	C17(1.05); C78(1.05)	LDD1589	[16]
LDCM0386	CL116	HEK-293T	C17(1.04); C78(0.94)	LDD1590	[16]
LDCM0387	CL117	HEK-293T	C17(1.09); C78(1.04)	LDD1591	[16]
LDCM0388	CL118	HEK-293T	C17(0.95); C78(0.90)	LDD1592	[16]
LDCM0389	CL119	HEK-293T	C17(1.26); C78(1.18)	LDD1593	[16]
LDCM0390	CL12	HEK-293T	C78(1.29)	LDD1594	[16]
LDCM0391	CL120	HEK-293T	C17(1.09); C78(0.99)	LDD1595	[16]
LDCM0392	CL121	HEK-293T	C17(1.05); C78(0.98)	LDD1596	[16]
LDCM0393	CL122	HEK-293T	C17(0.98); C78(1.19)	LDD1597	[16]
LDCM0394	CL123	HEK-293T	C17(1.07); C78(0.88)	LDD1598	[16]
LDCM0395	CL124	HEK-293T	C17(1.03); C78(1.02)	LDD1599	[16]
LDCM0396	CL125	HEK-293T	C17(1.13); C78(1.08)	LDD1600	[16]
LDCM0397	CL126	HEK-293T	C17(1.09); C78(1.25)	LDD1601	[16]
LDCM0398	CL127	HEK-293T	C17(0.92); C78(1.00)	LDD1602	[16]
LDCM0399	CL128	HEK-293T	C17(0.93); C78(1.03)	LDD1603	[16]
LDCM0400	CL13	HEK-293T	C17(0.94); C78(1.11)	LDD1604	[16]
LDCM0401	CL14	HEK-293T	C17(1.11); C78(1.01)	LDD1605	[16]
LDCM0402	CL15	HEK-293T	C17(1.07); C78(1.13)	LDD1606	[16]
LDCM0403	CL16	HEK-293T	C17(1.04); C78(1.02)	LDD1607	[16]
LDCM0404	CL17	HEK-293T	C78(1.31)	LDD1608	[16]
LDCM0405	CL18	HEK-293T	C17(1.16); C78(1.10)	LDD1609	[16]
LDCM0406	CL19	HEK-293T	C17(1.00); C78(1.10)	LDD1610	[16]
LDCM0407	CL2	HEK-293T	C17(1.06); C78(1.10)	LDD1611	[16]
LDCM0408	CL20	HEK-293T	C17(0.96); C78(1.02)	LDD1612	[16]
LDCM0409	CL21	HEK-293T	C17(0.96); C78(0.90)	LDD1613	[16]
LDCM0410	CL22	HEK-293T	C17(1.07); C78(1.10)	LDD1614	[16]
LDCM0411	CL23	HEK-293T	C17(1.06); C78(1.19)	LDD1615	[16]
LDCM0412	CL24	HEK-293T	C78(1.30)	LDD1616	[16]
LDCM0413	CL25	HEK-293T	C17(1.07); C78(1.00)	LDD1617	[16]
LDCM0414	CL26	HEK-293T	C17(1.04); C78(1.11)	LDD1618	[16]
LDCM0415	CL27	HEK-293T	C17(1.20); C78(1.11)	LDD1619	[16]
LDCM0416	CL28	HEK-293T	C17(1.01); C78(0.92)	LDD1620	[16]
LDCM0417	CL29	HEK-293T	C78(1.37)	LDD1621	[16]
LDCM0418	CL3	HEK-293T	C17(1.17); C78(0.92)	LDD1622	[16]
LDCM0419	CL30	HEK-293T	C17(1.06); C78(1.10)	LDD1623	[16]
LDCM0420	CL31	HEK-293T	C17(1.03); C78(0.87)	LDD1624	[16]
LDCM0421	CL32	HEK-293T	C17(1.08); C78(0.96)	LDD1625	[16]
LDCM0422	CL33	HEK-293T	C17(0.97); C78(1.09)	LDD1626	[16]
LDCM0423	CL34	HEK-293T	C17(1.03); C78(1.12)	LDD1627	[16]
LDCM0424	CL35	HEK-293T	C17(0.96); C78(1.04)	LDD1628	[16]
LDCM0425	CL36	HEK-293T	C78(1.07)	LDD1629	[16]
LDCM0426	CL37	HEK-293T	C17(1.05); C78(1.09)	LDD1630	[16]
LDCM0428	CL39	HEK-293T	C17(0.98); C78(0.94)	LDD1632	[16]
LDCM0429	CL4	HEK-293T	C17(1.13); C78(0.91)	LDD1633	[16]
LDCM0430	CL40	HEK-293T	C17(1.06); C78(1.02)	LDD1634	[16]
LDCM0431	CL41	HEK-293T	C78(0.92)	LDD1635	[16]
LDCM0432	CL42	HEK-293T	C17(0.96); C78(1.01)	LDD1636	[16]
LDCM0433	CL43	HEK-293T	C17(1.15); C78(0.95)	LDD1637	[16]
LDCM0434	CL44	HEK-293T	C17(1.04); C78(0.97)	LDD1638	[16]
LDCM0435	CL45	HEK-293T	C17(0.95); C78(1.04)	LDD1639	[16]
LDCM0436	CL46	HEK-293T	C17(0.95); C78(1.03)	LDD1640	[16]
LDCM0437	CL47	HEK-293T	C17(0.95); C78(1.19)	LDD1641	[16]
LDCM0438	CL48	HEK-293T	C78(1.18)	LDD1642	[16]
LDCM0439	CL49	HEK-293T	C17(1.06); C78(1.10)	LDD1643	[16]
LDCM0440	CL5	HEK-293T	C78(1.08)	LDD1644	[16]
LDCM0441	CL50	HEK-293T	C17(1.01); C78(1.16)	LDD1645	[16]
LDCM0443	CL52	HEK-293T	C17(1.00); C78(0.95)	LDD1646	[16]
LDCM0444	CL53	HEK-293T	C78(1.04)	LDD1647	[16]
LDCM0445	CL54	HEK-293T	C17(1.17); C78(1.08)	LDD1648	[16]
LDCM0446	CL55	HEK-293T	C17(0.98); C78(1.00)	LDD1649	[16]
LDCM0447	CL56	HEK-293T	C17(1.07); C78(1.18)	LDD1650	[16]
LDCM0448	CL57	HEK-293T	C17(0.98); C78(0.91)	LDD1651	[16]
LDCM0449	CL58	HEK-293T	C17(1.24); C78(1.00)	LDD1652	[16]
LDCM0450	CL59	HEK-293T	C17(1.17); C78(1.24)	LDD1653	[16]
LDCM0451	CL6	HEK-293T	C17(1.02); C78(1.13)	LDD1654	[16]
LDCM0452	CL60	HEK-293T	C78(1.18)	LDD1655	[16]
LDCM0453	CL61	HEK-293T	C17(1.04); C78(0.97)	LDD1656	[16]
LDCM0454	CL62	HEK-293T	C17(1.08); C78(1.04)	LDD1657	[16]
LDCM0455	CL63	HEK-293T	C17(1.38); C78(1.00)	LDD1658	[16]
LDCM0456	CL64	HEK-293T	C17(1.04); C78(0.98)	LDD1659	[16]
LDCM0457	CL65	HEK-293T	C78(1.10)	LDD1660	[16]
LDCM0458	CL66	HEK-293T	C17(1.05); C78(0.95)	LDD1661	[16]
LDCM0459	CL67	HEK-293T	C17(0.97); C78(1.01)	LDD1662	[16]
LDCM0460	CL68	HEK-293T	C17(1.01); C78(1.09)	LDD1663	[16]
LDCM0461	CL69	HEK-293T	C17(1.00); C78(1.01)	LDD1664	[16]
LDCM0462	CL7	HEK-293T	C17(0.92); C78(0.97)	LDD1665	[16]
LDCM0463	CL70	HEK-293T	C17(1.05); C78(1.04)	LDD1666	[16]
LDCM0464	CL71	HEK-293T	C17(0.94); C78(1.08)	LDD1667	[16]
LDCM0465	CL72	HEK-293T	C78(1.15)	LDD1668	[16]
LDCM0466	CL73	HEK-293T	C17(1.09); C78(1.06)	LDD1669	[16]
LDCM0467	CL74	HEK-293T	C17(1.01); C78(0.94)	LDD1670	[16]
LDCM0469	CL76	HEK-293T	C17(1.06); C78(0.91)	LDD1672	[16]
LDCM0470	CL77	HEK-293T	C78(0.95)	LDD1673	[16]
LDCM0471	CL78	HEK-293T	C17(0.99); C78(1.14)	LDD1674	[16]
LDCM0472	CL79	HEK-293T	C17(1.13); C78(0.95)	LDD1675	[16]
LDCM0473	CL8	HEK-293T	C17(0.92); C78(1.37)	LDD1676	[16]
LDCM0474	CL80	HEK-293T	C17(1.13); C78(1.10)	LDD1677	[16]
LDCM0475	CL81	HEK-293T	C17(1.01); C78(1.01)	LDD1678	[16]
LDCM0476	CL82	HEK-293T	C17(1.06); C78(0.96)	LDD1679	[16]
LDCM0477	CL83	HEK-293T	C17(0.96); C78(0.98)	LDD1680	[16]
LDCM0478	CL84	HEK-293T	C78(1.25)	LDD1681	[16]
LDCM0479	CL85	HEK-293T	C17(1.22); C78(0.97)	LDD1682	[16]
LDCM0480	CL86	HEK-293T	C17(1.07); C78(1.01)	LDD1683	[16]
LDCM0481	CL87	HEK-293T	C17(0.94); C78(1.09)	LDD1684	[16]
LDCM0482	CL88	HEK-293T	C17(1.02); C78(1.02)	LDD1685	[16]
LDCM0483	CL89	HEK-293T	C78(0.97)	LDD1686	[16]
LDCM0484	CL9	HEK-293T	C17(1.08); C78(1.28)	LDD1687	[16]
LDCM0485	CL90	HEK-293T	C17(1.10); C78(0.85)	LDD1688	[16]
LDCM0486	CL91	HEK-293T	C17(0.99); C78(1.02)	LDD1689	[16]
LDCM0487	CL92	HEK-293T	C17(1.21); C78(1.04)	LDD1690	[16]
LDCM0488	CL93	HEK-293T	C17(1.06); C78(0.91)	LDD1691	[16]
LDCM0489	CL94	HEK-293T	C17(1.04); C78(1.08)	LDD1692	[16]
LDCM0490	CL95	HEK-293T	C17(0.90); C78(1.19)	LDD1693	[16]
LDCM0491	CL96	HEK-293T	C78(1.13)	LDD1694	[16]
LDCM0492	CL97	HEK-293T	C17(1.03); C78(1.06)	LDD1695	[16]
LDCM0493	CL98	HEK-293T	C17(1.04); C78(0.98)	LDD1696	[16]
LDCM0494	CL99	HEK-293T	C17(1.13); C78(0.95)	LDD1697	[16]
LDCM0189	Compound 16	HEK-293T	13.25	LDD0492	[12]
LDCM0185	Compound 17	HEK-293T	11.49	LDD0504	[12]
LDCM0184	Compound 20	HEK-293T	15.27	LDD0503	[12]
LDCM0191	Compound 21	HEK-293T	6.31	LDD0493	[12]
LDCM0186	Compound 31	HEK-293T	20.20	LDD0506	[12]
LDCM0187	Compound 32	HEK-293T	51.28	LDD0507	[12]
LDCM0188	Compound 33	HEK-293T	9.30	LDD0505	[12]
LDCM0190	Compound 34	HEK-293T	17.54	LDD0497	[12]
LDCM0192	Compound 35	HEK-293T	9.57	LDD0491	[12]
LDCM0193	Compound 36	HEK-293T	8.26	LDD0494	[12]
LDCM0194	Compound 37	HEK-293T	10.36	LDD0498	[12]
LDCM0195	Compound 38	HEK-293T	12.42	LDD0499	[12]
LDCM0196	Compound 39	HEK-293T	8.97	LDD0496	[12]
LDCM0197	Compound 40	HEK-293T	15.27	LDD0495	[12]
LDCM0495	E2913	HEK-293T	C17(0.99); C78(1.00)	LDD1698	[16]
LDCM0468	Fragment33	HEK-293T	C17(0.89); C78(1.23)	LDD1671	[16]
LDCM0427	Fragment51	HEK-293T	C17(1.05); C78(0.98)	LDD1631	[16]
LDCM0022	KB02	HEK-293T	C17(0.91)	LDD1492	[16]
LDCM0023	KB03	HEK-293T	C17(1.06)	LDD1497	[16]
LDCM0024	KB05	SK-MEL-28	C17(2.67)	LDD3427	[3]
LDCM0109	NEM	HeLa	N.A.	LDD0227	[4]
LDCM0628	OTUB2-COV-1	HEK-293T	C9(1.41)	LDD2207	[17]
LDCM0131	RA190	MM1.R	C17(1.56)	LDD0304	[18]
LDCM0084	Ro 48-8071	A-549	20.00	LDD0145	[13]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme

Click To Hide/Show 4 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
MYG1 exonuclease (MYG1)	MYG1 family	Q9HB07
Serine/threonine-protein kinase PAK 1 (PAK1)	STE Ser/Thr protein kinase family	Q13153
Fibroblast growth factor receptor 3 (FGFR3)	Tyr protein kinase family	P22607
Coagulation factor XIII A chain (F13A1)	Transglutaminase family	P00488

Transporter and channel

Click To Hide/Show 5 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Glutamate receptor ionotropic, NMDA 2C (GRIN2C)	Glutamate-gated ion channel family	Q14957
Mitochondrial pyruvate carrier 2 (MPC2)	Mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family	O95563
Alpha-crystallin A chain (CRYAA)	Small heat shock protein (HSP20) family	P02489
Mitochondrial import inner membrane translocase subunit Tim23 (TIMM23)	Tim17/Tim22/Tim23 family	O14925
Wolframin (WFS1)	.	O76024

Other

Click To Hide/Show 8 Protein(s) Interacting with This Target

Protein name	Family	Uniprot ID
Lipid transferase CIDEB (CIDEB)	CIDE family	Q9UHD4
Cytoplasmic dynein 1 heavy chain 1 (DYNC1H1)	Dynein heavy chain family	Q14204
Progranulin (GRN)	Granulin family	P28799
Heat shock protein beta-1 (HSPB1)	Small heat shock protein (HSP20) family	P04792
Gelsolin (GSN)	Villin/gelsolin family	P06396
RING finger protein 11 (RNF11)	.	Q9Y3C5
Testis-expressed protein 44 (TEX44)	.	Q53QW1
Ubiquilin-1 (UBQLN1)	.	Q9UMX0

References

1	Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1. Mass spectrometry data entry: PXD018580
2	Discovery of Potent and Selective Inhibitors against Protein-Derived Electrophilic Cofactors. J Am Chem Soc. 2022 Mar 30;144(12):5377-5388. doi: 10.1021/jacs.1c12748. Epub 2022 Mar 2.
3	DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22. Mass spectrometry data entry: PXD047840
4	ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
5	SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18. Mass spectrometry data entry*: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6	Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24. Mass spectrometry data entry: PXD029255
7	Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25. Mass spectrometry data entry: PXD031019
8	DFT-Guided Discovery of Ethynyl-Triazolyl-Phosphinates as Modular Electrophiles for Chemoselective Cysteine Bioconjugation and Profiling. Angew Chem Int Ed Engl. 2022 Oct 10;61(41):e202205348. doi: 10.1002/anie.202205348. Epub 2022 Aug 22. Mass spectrometry data entry: PXD033004
9	N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w. Mass spectrometry data entry: PXD041264
10	A Chemical Proteomic Analysis of Illudin-Interacting Proteins. Chemistry. 2019 Sep 25;25(54):12644-12651. doi: 10.1002/chem.201902919. Epub 2019 Sep 3. Mass spectrometry data entry: PXD014175
11	Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26. Mass spectrometry data entry: PXD041587
12	Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
13	A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
14	Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b. Mass spectrometry data entry: PXD025652
15	Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20. Mass spectrometry data entry: PXD007570
16	Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19. Mass spectrometry data entry: PXD044402
17	Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22.
18	Physical and Functional Analysis of the Putative Rpn13 Inhibitor RA190. Cell Chem Biol. 2020 Nov 19;27(11):1371-1382.e6. doi: 10.1016/j.chembiol.2020.08.007. Epub 2020 Aug 27.

Details of the Target

Citation

Visitor Map

Correspondence

Prof. Feng Zhu

Prof. Feng Ni