General Information of Experiment

Probe Name C051  Probe Info 
Probe concentration Probe:50uM; negative probe:50uM
Criteria Quantification: AfBPP Probe vs Negative Probe
Quantitative Method
TMT
In Vivo Experiment Model Model Type Living cell
Derived Tissue Peripheral blood
Disease Model Normal
Model Name Human normal cells (HEK-293T)
Note Negative probe:C#CCCC1(CCC(NC)=O)N=N1

Interaction Altas of This Experiment [1]

Enzyme
Click to Show/Hide to Show 11 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP05862  NAD(P) transhydrogenase, mitochondrial (NNT) 15.5
 LDTP12363  Lysophosphatidic acid phosphatase type 6 (ACP6) 11.2
 LDTP00832  NADH dehydrogenase 1 beta subcomplex subunit 3 (NDUFB3) 5.9
 LDTP00697  Cytochrome b5 type B (CYB5B) 5.7
 LDTP03540  Heme oxygenase 2 (HMOX2) 5.7
 LDTP13282  Prenylcysteine oxidase 1 (PCYOX1) 5.7
 LDTP13189  Cytochrome b-c1 complex subunit 9 (UQCR10) 5.3
 LDTP06384  Ribosomal protein S6 kinase alpha-1 (RPS6KA1) 5.3
 LDTP12253  Glycerol-3-phosphate acyltransferase 1, mitochondrial (GPAM) 5.2
 LDTP06645  Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial (HADH) 5.1
 LDTP12867  Very-long-chain enoyl-CoA reductase (TECR) 5.0
Transporter and channel
Click to Show/Hide to Show 10 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP01059  Mitochondrial import inner membrane translocase subunit Tim17-B (TIMM17B) 13.6
 LDTP02724  Cytochrome c oxidase subunit 7A2, mitochondrial (COX7A2) 11.9
 LDTP03277  ER lumen protein-retaining receptor 1 (KDELR1) 10.8
 LDTP10913  Mitochondrial import inner membrane translocase subunit Tim17-A (TIMM17A) 10.0
 LDTP08881  Transmembrane protein 199 (TMEM199) 8.6
 LDTP04033  Translocon-associated protein subunit alpha (SSR1) 6.1
 LDTP03132  Voltage-dependent anion-selective channel protein 1 (VDAC1) 5.2
 LDTP11813  Solute carrier family 25 member 32 (SLC25A32) 5.2
 LDTP14099  Mitochondrial import inner membrane translocase subunit Tim22 (TIMM22) 5.1
 LDTP10958  Sigma non-opioid intracellular receptor 1 (SIGMAR1) 5.0
Other
Click to Show/Hide to Show 8 Protein Related to This Bioclass
Target ID Target Name Binding Ratio
 LDTP12565  Mitochondrial import receptor subunit TOM22 homolog (TOMM22) 11.1
 LDTP11076  Apolipoprotein L2 (APOL2) 10.1
 LDTP03678  ER lumen protein-retaining receptor 2 (KDELR2) 9.2
 LDTP12412  Reticulon-4 (RTN4) 7.0
 LDTP05160  Nucleobindin-2 (NUCB2) 6.2
 LDTP15067  Ubiquinol-cytochrome c reductase complex assembly factor 6 (UQCC6) 6.1
 LDTP15634  Ubiquinol-cytochrome c reductase complex assembly factor 5 (UQCC5) 5.8
 LDTP15420  Mitochondrial import receptor subunit TOM5 homolog (TOMM5) 5.3

References

1 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587