Details of the Target

General Information of Target

Target ID LDTP13189
Target Name Cytochrome b-c1 complex subunit 9 (UQCR10)
Gene Name UQCR10
Gene ID 29796
Synonyms
UCRC; Cytochrome b-c1 complex subunit 9; Complex III subunit 9; Complex III subunit X; Cytochrome c1 non-heme 7 kDa protein; Ubiquinol-cytochrome c reductase complex 7.2 kDa protein
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MAESAPARHRRKRRSTPLTSSTLPSQATEKSSYFQTTEISLWTVVAAIQAVEKKMESQAA
RLQSLEGRTGTAEKKLADCEKMAVEFGNQLEGKWAVLGTLLQEYGLLQRRLENVENLLRN
RNFWILRLPPGSKGEAPKVSRSLENDGVCFTEQEWENLEDWQKELYRNVMESNYETLVSL
KVLGQTEGEAELGTEMLGDLEEEGPGGAHPAGGVMIKQELQYTQEGPADLPGEFSCIAEE
QAFLSPEQTELWGGQGSSVLLETGPGDSTLEEPVGSRVPSSSRTVGCPKQKSHRQVQLDQ
ECGQGLKLKKDTSRPYECSECEITFRYKQQLATHLRSHSGWGSCTPEEPEESLRPRPRLK
PQTKKAKLHQCDVCLRSFSCKVSLVTHQRCHLQEGPSAGQHVQERFSPNSLVALPGHIPW
RKSRSSLICGYCGKSFSHPSDLVRHQRIHTGERPYSCTECEKSFVQKQHLLQHQKIHQRE
RGGLALEPGRPNGLL
Target Bioclass
Enzyme
Family
UQCR10/QCR9 family
Subcellular location
Mitochondrion inner membrane
Function
Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.
Uniprot ID
Q9UDW1
Ensemble ID
ENST00000330029.6
HGNC ID
HGNC:30863
ChEMBL ID
CHEMBL2388

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 8 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
CHEMBL5175495
 Probe Info  		6.16  LDD0196  [1]
N1
 Probe Info  		100.00  LDD0242  [2]
TH211
 Probe Info  		Y11(19.96)  LDD0260  [3]
STPyne
 Probe Info  		K54(10.00); K57(5.73); K59(10.00)  LDD0277  [4]
Jackson_14
 Probe Info  		2.22  LDD0123  [5]
m-APA
 Probe Info  		N.A.  LDD2231  [6]
Acrolein
 Probe Info  		N.A.  LDD0217  [7]
W1
 Probe Info  		D37(0.00); D45(0.00); Y44(0.00); N48(0.00)  LDD0236  [8]
PAL-AfBPP Probe
Click To Hide/Show 144 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C004
 Probe Info  		10.06  LDD1714  [9]
C007
 Probe Info  		4.96  LDD1716  [9]
C008
 Probe Info  		4.96  LDD1717  [9]
C017
 Probe Info  		5.86  LDD1725  [9]
C022
 Probe Info  		67.18  LDD1728  [9]
C026
 Probe Info  		14.12  LDD1732  [9]
C040
 Probe Info  		41.36  LDD1740  [9]
C041
 Probe Info  		13.74  LDD1741  [9]
C049
 Probe Info  		16.56  LDD1747  [9]
C051
 Probe Info  		5.31  LDD1749  [9]
C052
 Probe Info  		7.11  LDD1750  [9]
C053
 Probe Info  		13.09  LDD1751  [9]
C055
 Probe Info  		51.27  LDD1752  [9]
C056
 Probe Info  		86.82  LDD1753  [9]
C059
 Probe Info  		6.77  LDD1756  [9]
C063
 Probe Info  		44.32  LDD1760  [9]
C064
 Probe Info  		11.71  LDD1761  [9]
C067
 Probe Info  		7.16  LDD1763  [9]
C070
 Probe Info  		37.27  LDD1766  [9]
C072
 Probe Info  		15.45  LDD1768  [9]
C082
 Probe Info  		9.58  LDD1774  [9]
C087
 Probe Info  		19.29  LDD1779  [9]
C091
 Probe Info  		16.22  LDD1782  [9]
C092
 Probe Info  		22.78  LDD1783  [9]
C095
 Probe Info  		8.69  LDD1786  [9]
C100
 Probe Info  		13.09  LDD1789  [9]
C106
 Probe Info  		99.73  LDD1793  [9]
C107
 Probe Info  		14.72  LDD1794  [9]
C108
 Probe Info  		34.06  LDD1795  [9]
C112
 Probe Info  		99.73  LDD1799  [9]
C129
 Probe Info  		9.38  LDD1811  [9]
C130
 Probe Info  		16.91  LDD1812  [9]
C134
 Probe Info  		84.45  LDD1816  [9]
C135
 Probe Info  		30.48  LDD1817  [9]
C139
 Probe Info  		16.80  LDD1821  [9]
C140
 Probe Info  		10.56  LDD1822  [9]
C141
 Probe Info  		28.84  LDD1823  [9]
C143
 Probe Info  		56.49  LDD1825  [9]
C147
 Probe Info  		7.36  LDD1829  [9]
C153
 Probe Info  		56.49  LDD1834  [9]
C159
 Probe Info  		22.63  LDD1839  [9]
C160
 Probe Info  		20.97  LDD1840  [9]
C161
 Probe Info  		36.25  LDD1841  [9]
C163
 Probe Info  		17.51  LDD1843  [9]
C165
 Probe Info  		20.11  LDD1845  [9]
C166
 Probe Info  		10.06  LDD1846  [9]
C177
 Probe Info  		10.48  LDD1856  [9]
C178
 Probe Info  		73.01  LDD1857  [9]
C186
 Probe Info  		9.38  LDD1864  [9]
C187
 Probe Info  		99.73  LDD1865  [9]
C191
 Probe Info  		57.28  LDD1868  [9]
C193
 Probe Info  		32.90  LDD1869  [9]
C194
 Probe Info  		32.00  LDD1870  [9]
C196
 Probe Info  		28.05  LDD1872  [9]
C197
 Probe Info  		5.82  LDD1873  [9]
C198
 Probe Info  		30.48  LDD1874  [9]
C201
 Probe Info  		99.73  LDD1877  [9]
C204
 Probe Info  		5.62  LDD1879  [9]
C206
 Probe Info  		86.82  LDD1881  [9]
C207
 Probe Info  		23.10  LDD1882  [9]
C210
 Probe Info  		99.73  LDD1884  [9]
C211
 Probe Info  		13.83  LDD1885  [9]
C213
 Probe Info  		37.01  LDD1887  [9]
C214
 Probe Info  		5.43  LDD1888  [9]
C218
 Probe Info  		43.71  LDD1892  [9]
C219
 Probe Info  		7.26  LDD1893  [9]
C220
 Probe Info  		58.49  LDD1894  [9]
C225
 Probe Info  		10.27  LDD1898  [9]
C226
 Probe Info  		9.19  LDD1899  [9]
C228
 Probe Info  		56.49  LDD1901  [9]
C229
 Probe Info  		14.93  LDD1902  [9]
C231
 Probe Info  		65.34  LDD1904  [9]
C232
 Probe Info  		99.73  LDD1905  [9]
C233
 Probe Info  		30.91  LDD1906  [9]
C234
 Probe Info  		17.03  LDD1907  [9]
C235
 Probe Info  		81.57  LDD1908  [9]
C238
 Probe Info  		45.57  LDD1911  [9]
C240
 Probe Info  		14.83  LDD1913  [9]
C243
 Probe Info  		32.67  LDD1916  [9]
C244
 Probe Info  		25.99  LDD1917  [9]
C245
 Probe Info  		8.51  LDD1918  [9]
C246
 Probe Info  		45.57  LDD1919  [9]
C249
 Probe Info  		27.28  LDD1922  [9]
C252
 Probe Info  		30.48  LDD1925  [9]
C258
 Probe Info  		6.50  LDD1931  [9]
C264
 Probe Info  		50.21  LDD1935  [9]
C265
 Probe Info  		24.93  LDD1936  [9]
C270
 Probe Info  		9.85  LDD1940  [9]
C273
 Probe Info  		11.31  LDD1943  [9]
C277
 Probe Info  		37.53  LDD1947  [9]
C278
 Probe Info  		95.67  LDD1948  [9]
C285
 Probe Info  		27.86  LDD1955  [9]
C287
 Probe Info  		21.11  LDD1957  [9]
C288
 Probe Info  		7.94  LDD1958  [9]
C289
 Probe Info  		47.84  LDD1959  [9]
C293
 Probe Info  		70.03  LDD1963  [9]
C296
 Probe Info  		83.87  LDD1966  [9]
C299
 Probe Info  		18.25  LDD1968  [9]
C304
 Probe Info  		5.35  LDD1973  [9]
C305
 Probe Info  		30.06  LDD1974  [9]
C307
 Probe Info  		5.86  LDD1975  [9]
C310
 Probe Info  		14.12  LDD1977  [9]
C313
 Probe Info  		27.28  LDD1980  [9]
C314
 Probe Info  		58.49  LDD1981  [9]
C317
 Probe Info  		9.78  LDD1983  [9]
C322
 Probe Info  		10.78  LDD1988  [9]
C326
 Probe Info  		17.27  LDD1990  [9]
C338
 Probe Info  		19.16  LDD2001  [9]
C339
 Probe Info  		22.32  LDD2002  [9]
C343
 Probe Info  		51.98  LDD2005  [9]
C348
 Probe Info  		28.25  LDD2009  [9]
C349
 Probe Info  		39.40  LDD2010  [9]
C350
 Probe Info  		99.73  LDD2011  [9]
C354
 Probe Info  		9.38  LDD2015  [9]
C355
 Probe Info  		54.19  LDD2016  [9]
C356
 Probe Info  		20.39  LDD2017  [9]
C357
 Probe Info  		8.69  LDD2018  [9]
C373
 Probe Info  		8.69  LDD2033  [9]
C376
 Probe Info  		21.41  LDD2036  [9]
C378
 Probe Info  		9.13  LDD2037  [9]
C380
 Probe Info  		5.28  LDD2039  [9]
C382
 Probe Info  		24.08  LDD2041  [9]
C383
 Probe Info  		28.25  LDD2042  [9]
C386
 Probe Info  		13.64  LDD2045  [9]
C388
 Probe Info  		99.73  LDD2047  [9]
C390
 Probe Info  		99.73  LDD2049  [9]
C391
 Probe Info  		19.56  LDD2050  [9]
C392
 Probe Info  		5.13  LDD2051  [9]
C396
 Probe Info  		6.19  LDD2055  [9]
C399
 Probe Info  		13.09  LDD2058  [9]
C403
 Probe Info  		43.71  LDD2061  [9]
C407
 Probe Info  		54.95  LDD2064  [9]
C413
 Probe Info  		27.67  LDD2069  [9]
C419
 Probe Info  		14.52  LDD2074  [9]
C420
 Probe Info  		18.25  LDD2075  [9]
C424
 Probe Info  		10.27  LDD2079  [9]
C426
 Probe Info  		22.78  LDD2081  [9]
C429
 Probe Info  		30.91  LDD2084  [9]
C431
 Probe Info  		74.03  LDD2086  [9]
C433
 Probe Info  		5.98  LDD2088  [9]
BD-F
 Probe Info  		Y44(0.00); H46(0.00)  LDD0024  [10]
LD-F
 Probe Info  		H46(0.00); Y44(0.00)  LDD0015  [10]
Photocelecoxib
 Probe Info  		N.A.  LDD0153  [11]
OEA-DA
 Probe Info  		4.38  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0108  Chloroacetamide HeLa N.A.  LDD0222  [7]
 LDCM0107  IAA HeLa N.A.  LDD0221  [7]
 LDCM0109  NEM HeLa N.A.  LDD0223  [7]
 LDCM0016  Ranjitkar_cp1 MDA-MB-231 2.22  LDD0123  [5]

The Interaction Atlas With This Target

The Drug(s) Related To This Target

Investigative
Click To Hide/Show 9 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-nonyl-4-quinolinol 1-oxide Small molecular drug DB08453
5-heptyl-6-hydroxy-13-benzothiazole-47-dione Small molecular drug DB07636
6-hydroxy-5-undecyl-47-benzothiazoledione Small molecular drug DB04799
Ubiquinone Q2 Small molecular drug DB08690
(5s)-3-anilino-5-(24-difluorophenyl)-5-methyl-13-oxazolidine-24-dione . DB07763
(S)-famoxadone . DB07778
2-hexyloxy-6-hydroxymethyl-tetrahydro-pyran-345-triol . DB04141
Azoxystrobin . DB07401
Methyl (2z)-3-methoxy-2-{2-[(E)-2-phenylvinyl]Phenyl}Acrylate . DB08330

References

1 Charting the Chemical Space of Acrylamide-Based Inhibitors of zDHHC20. ACS Med Chem Lett. 2022 Sep 26;13(10):1648-1654. doi: 10.1021/acsmedchemlett.2c00336. eCollection 2022 Oct 13.
2 Cyclopropenone, Cyclopropeniminium Ion, and Cyclopropenethione as Novel Electrophilic Warheads for Potential Target Discovery of Triple-Negative Breast Cancer. J Med Chem. 2023 Feb 23;66(4):2851-2864. doi: 10.1021/acs.jmedchem.2c01889. Epub 2023 Feb 10.
3 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
4 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
5 Appendage and Scaffold Diverse Fully Functionalized Small-Molecule Probes via a Minimalist Terminal Alkyne-Aliphatic Diazirine Isocyanide. J Org Chem. 2018 Sep 21;83(18):11245-11253. doi: 10.1021/acs.joc.8b01831. Epub 2018 Aug 31.
6 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377
7 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
8 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
9 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
10 Evaluation of fully-functionalized diazirine tags for chemical proteomic applications. Chem Sci. 2021 May 7;12(22):7839-7847. doi: 10.1039/d1sc01360b.
Mass spectrometry data entry: PXD025652
11 Small Molecule Interactome Mapping by Photoaffinity Labeling Reveals Binding Site Hotspots for the NSAIDs. J Am Chem Soc. 2018 Mar 28;140(12):4259-4268. doi: 10.1021/jacs.7b11639. Epub 2018 Mar 15.
Mass spectrometry data entry: PXD007094
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570