Details of the Target

General Information of Target

Target ID LDTP11076
Target Name Apolipoprotein L2 (APOL2)
Gene Name APOL2
Gene ID 23780
Synonyms
Apolipoprotein L2; Apolipoprotein L-II; ApoL-II
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MERQEESLSARPALETEGLRFLHTTVGSLLATYGWYIVFSCILLYVVFQKLSARLRALRQ
RQLDRAAAAVEPDVVVKRQEALAAARLKMQEELNAQVEKHKEKLKQLEEEKRRQKIEMWD
SMQEGKSYKGNAKKPQEEDSPGPSTSSVLKRKSDRKPLRGGGYNPLSGEGGGACSWRPGR
RGPSSGGUG
Target Bioclass
Other
Family
Apolipoprotein L family
Subcellular location
Cytoplasm
Function May affect the movement of lipids in the cytoplasm or allow the binding of lipids to organelles.
Uniprot ID
Q9BQE5
Ensemble ID
ENST00000249066.10
HGNC ID
HGNC:619

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FBPP2
 Probe Info  		3.62  LDD0318  [1]
TG42
 Probe Info  		5.80  LDD0326  [2]
STPyne
 Probe Info  		K320(10.00); K73(10.00)  LDD0277  [3]
m-APA
 Probe Info  		12.15  LDD0403  [4]
Acrolein
 Probe Info  		N.A.  LDD0217  [5]
AOyne
 Probe Info  		13.40  LDD0443  [6]
PAL-AfBPP Probe
Click To Hide/Show 179 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
C001
 Probe Info  		10.48  LDD1711  [7]
C002
 Probe Info  		6.19  LDD1712  [7]
C003
 Probe Info  		22.16  LDD1713  [7]
C004
 Probe Info  		31.34  LDD1714  [7]
C007
 Probe Info  		12.21  LDD1716  [7]
C008
 Probe Info  		9.92  LDD1717  [7]
C010
 Probe Info  		15.89  LDD1719  [7]
C011
 Probe Info  		14.22  LDD1720  [7]
C018
 Probe Info  		5.90  LDD1726  [7]
C022
 Probe Info  		98.36  LDD1728  [7]
C026
 Probe Info  		28.05  LDD1732  [7]
C039
 Probe Info  		15.03  LDD1739  [7]
C040
 Probe Info  		53.45  LDD1740  [7]
C041
 Probe Info  		35.26  LDD1741  [7]
C044
 Probe Info  		5.70  LDD1743  [7]
C049
 Probe Info  		12.55  LDD1747  [7]
C051
 Probe Info  		10.06  LDD1749  [7]
C052
 Probe Info  		9.38  LDD1750  [7]
C053
 Probe Info  		14.52  LDD1751  [7]
C055
 Probe Info  		43.71  LDD1752  [7]
C056
 Probe Info  		70.52  LDD1753  [7]
C059
 Probe Info  		8.17  LDD1756  [7]
C060
 Probe Info  		5.28  LDD1757  [7]
C063
 Probe Info  		52.71  LDD1760  [7]
C064
 Probe Info  		15.56  LDD1761  [7]
C065
 Probe Info  		5.10  LDD1762  [7]
C067
 Probe Info  		21.26  LDD1763  [7]
C070
 Probe Info  		99.73  LDD1766  [7]
C071
 Probe Info  		19.29  LDD1767  [7]
C072
 Probe Info  		50.21  LDD1768  [7]
C082
 Probe Info  		39.95  LDD1774  [7]
C085
 Probe Info  		15.56  LDD1777  [7]
C087
 Probe Info  		51.63  LDD1779  [7]
C095
 Probe Info  		11.96  LDD1786  [7]
C099
 Probe Info  		5.13  LDD1788  [7]
C100
 Probe Info  		12.55  LDD1789  [7]
C102
 Probe Info  		6.96  LDD1790  [7]
C106
 Probe Info  		99.73  LDD1793  [7]
C107
 Probe Info  		40.50  LDD1794  [7]
C108
 Probe Info  		51.63  LDD1795  [7]
C112
 Probe Info  		99.73  LDD1799  [7]
C129
 Probe Info  		42.22  LDD1811  [7]
C130
 Probe Info  		22.63  LDD1812  [7]
C131
 Probe Info  		5.58  LDD1813  [7]
C134
 Probe Info  		99.73  LDD1816  [7]
C135
 Probe Info  		56.49  LDD1817  [7]
C138
 Probe Info  		5.06  LDD1820  [7]
C139
 Probe Info  		34.06  LDD1821  [7]
C140
 Probe Info  		20.68  LDD1822  [7]
C141
 Probe Info  		64.89  LDD1823  [7]
C143
 Probe Info  		99.73  LDD1825  [7]
C145
 Probe Info  		15.24  LDD1827  [7]
C147
 Probe Info  		29.45  LDD1829  [7]
C153
 Probe Info  		99.73  LDD1834  [7]
C163
 Probe Info  		25.11  LDD1843  [7]
C165
 Probe Info  		30.91  LDD1845  [7]
C166
 Probe Info  		23.92  LDD1846  [7]
C169
 Probe Info  		99.73  LDD1849  [7]
C170
 Probe Info  		14.72  LDD1850  [7]
C173
 Probe Info  		10.06  LDD1853  [7]
C174
 Probe Info  		6.06  LDD1854  [7]
C187
 Probe Info  		80.45  LDD1865  [7]
C191
 Probe Info  		47.18  LDD1868  [7]
C193
 Probe Info  		12.73  LDD1869  [7]
C194
 Probe Info  		68.59  LDD1870  [7]
C196
 Probe Info  		81.01  LDD1872  [7]
C197
 Probe Info  		17.51  LDD1873  [7]
C198
 Probe Info  		70.03  LDD1874  [7]
C199
 Probe Info  		9.99  LDD1875  [7]
C210
 Probe Info  		92.41  LDD1884  [7]
C211
 Probe Info  		20.39  LDD1885  [7]
C213
 Probe Info  		32.00  LDD1887  [7]
C214
 Probe Info  		11.24  LDD1888  [7]
C216
 Probe Info  		5.28  LDD1890  [7]
C218
 Probe Info  		27.67  LDD1892  [7]
C219
 Probe Info  		10.34  LDD1893  [7]
C220
 Probe Info  		36.76  LDD1894  [7]
C225
 Probe Info  		27.28  LDD1898  [7]
C226
 Probe Info  		30.27  LDD1899  [7]
C228
 Probe Info  		99.73  LDD1901  [7]
C229
 Probe Info  		62.25  LDD1902  [7]
C231
 Probe Info  		99.73  LDD1904  [7]
C232
 Probe Info  		99.73  LDD1905  [7]
C233
 Probe Info  		93.05  LDD1906  [7]
C234
 Probe Info  		66.26  LDD1907  [7]
C235
 Probe Info  		99.73  LDD1908  [7]
C236
 Probe Info  		11.63  LDD1909  [7]
C238
 Probe Info  		99.73  LDD1911  [7]
C239
 Probe Info  		6.77  LDD1912  [7]
C240
 Probe Info  		58.49  LDD1913  [7]
C242
 Probe Info  		11.39  LDD1915  [7]
C243
 Probe Info  		77.71  LDD1916  [7]
C244
 Probe Info  		99.73  LDD1917  [7]
C245
 Probe Info  		12.73  LDD1918  [7]
C246
 Probe Info  		99.73  LDD1919  [7]
C249
 Probe Info  		83.87  LDD1922  [7]
C258
 Probe Info  		9.25  LDD1931  [7]
C260
 Probe Info  		8.22  LDD1932  [7]
C264
 Probe Info  		99.73  LDD1935  [7]
C265
 Probe Info  		79.34  LDD1936  [7]
C266
 Probe Info  		23.92  LDD1937  [7]
C269
 Probe Info  		18.25  LDD1939  [7]
C270
 Probe Info  		41.36  LDD1940  [7]
C271
 Probe Info  		5.06  LDD1941  [7]
C273
 Probe Info  		11.31  LDD1943  [7]
C277
 Probe Info  		27.28  LDD1947  [7]
C278
 Probe Info  		99.73  LDD1948  [7]
C280
 Probe Info  		13.74  LDD1950  [7]
C282
 Probe Info  		55.33  LDD1952  [7]
C284
 Probe Info  		82.71  LDD1954  [7]
C285
 Probe Info  		56.10  LDD1955  [7]
C286
 Probe Info  		5.35  LDD1956  [7]
C287
 Probe Info  		26.72  LDD1957  [7]
C288
 Probe Info  		15.78  LDD1958  [7]
C289
 Probe Info  		54.19  LDD1959  [7]
C290
 Probe Info  		6.73  LDD1960  [7]
C292
 Probe Info  		6.19  LDD1962  [7]
C293
 Probe Info  		85.04  LDD1963  [7]
C296
 Probe Info  		54.95  LDD1966  [7]
C297
 Probe Info  		6.87  LDD1967  [7]
C299
 Probe Info  		37.53  LDD1968  [7]
C300
 Probe Info  		6.28  LDD1969  [7]
C301
 Probe Info  		7.84  LDD1970  [7]
C303
 Probe Info  		6.68  LDD1972  [7]
C304
 Probe Info  		29.65  LDD1973  [7]
C305
 Probe Info  		46.21  LDD1974  [7]
C307
 Probe Info  		6.92  LDD1975  [7]
C310
 Probe Info  		17.63  LDD1977  [7]
C313
 Probe Info  		28.25  LDD1980  [7]
C314
 Probe Info  		30.06  LDD1981  [7]
C317
 Probe Info  		11.24  LDD1983  [7]
C322
 Probe Info  		13.18  LDD1988  [7]
C326
 Probe Info  		12.91  LDD1990  [7]
C327
 Probe Info  		7.16  LDD1991  [7]
C328
 Probe Info  		6.50  LDD1992  [7]
C333
 Probe Info  		9.78  LDD1996  [7]
C337
 Probe Info  		9.45  LDD2000  [7]
C338
 Probe Info  		99.73  LDD2001  [7]
C339
 Probe Info  		58.08  LDD2002  [7]
C348
 Probe Info  		66.26  LDD2009  [7]
C349
 Probe Info  		91.77  LDD2010  [7]
C350
 Probe Info  		99.73  LDD2011  [7]
C353
 Probe Info  		17.63  LDD2014  [7]
C354
 Probe Info  		15.56  LDD2015  [7]
C355
 Probe Info  		61.82  LDD2016  [7]
C356
 Probe Info  		18.13  LDD2017  [7]
C361
 Probe Info  		18.13  LDD2022  [7]
C362
 Probe Info  		99.73  LDD2023  [7]
C363
 Probe Info  		99.73  LDD2024  [7]
C364
 Probe Info  		99.73  LDD2025  [7]
C366
 Probe Info  		66.26  LDD2027  [7]
C367
 Probe Info  		36.50  LDD2028  [7]
C373
 Probe Info  		39.12  LDD2033  [7]
C376
 Probe Info  		86.22  LDD2036  [7]
C378
 Probe Info  		45.89  LDD2037  [7]
C379
 Probe Info  		5.13  LDD2038  [7]
C380
 Probe Info  		27.47  LDD2039  [7]
C382
 Probe Info  		99.73  LDD2041  [7]
C383
 Probe Info  		74.54  LDD2042  [7]
C386
 Probe Info  		21.56  LDD2045  [7]
C387
 Probe Info  		6.41  LDD2046  [7]
C388
 Probe Info  		99.73  LDD2047  [7]
C389
 Probe Info  		7.11  LDD2048  [7]
C405
 Probe Info  		12.13  LDD2063  [7]
C407
 Probe Info  		99.73  LDD2064  [7]
C408
 Probe Info  		10.85  LDD2065  [7]
C409
 Probe Info  		22.94  LDD2066  [7]
C413
 Probe Info  		99.73  LDD2069  [7]
C419
 Probe Info  		46.21  LDD2074  [7]
C420
 Probe Info  		40.79  LDD2075  [7]
C423
 Probe Info  		18.77  LDD2078  [7]
C424
 Probe Info  		22.94  LDD2079  [7]
C426
 Probe Info  		48.17  LDD2081  [7]
FFF probe14
 Probe Info  		20.00  LDD0477  [8]
FFF probe2
 Probe Info  		20.00  LDD0463  [8]
STS-2
 Probe Info  		N.A.  LDD0139  [9]
VE-P
 Probe Info  		N.A.  LDD0396  [10]
A-DA
 Probe Info  		2.16  LDD0143  [11]
OEA-DA
 Probe Info  		20.00  LDD0046  [12]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0156  Aniline NCI-H1299 12.15  LDD0403  [4]
 LDCM0083  Avasimibe A-549 2.16  LDD0143  [11]
 LDCM0109  NEM HeLa N.A.  LDD0224  [5]
 LDCM0084  Ro 48-8071 A-549 20.00  LDD0145  [11]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
E3 ubiquitin-protein ligase MARCHF3 (MARCHF3) . Q86UD3
Transporter and channel
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Pannexin-1 (PANX1) Pannexin family Q96RD7
Potassium voltage-gated channel subfamily A member 1 (KCNA1) Potassium channel family Q09470
Syntaxin-1A (STX1A) Syntaxin family Q16623
Transmembrane protein 179B (TMEM179B) TMEM179 family Q7Z7N9
Guided entry of tail-anchored proteins factor 1 (GET1) WRB/GET1 family O00258
Barttin (BSND) . Q8WZ55
Transmembrane protein 139 (TMEM139) . Q8IV31
Transmembrane protein 60 (TMEM60) . Q9H2L4
Other
Click To Hide/Show 16 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Apolipoprotein C-IV (APOC4) Apolipoprotein C4 family P55056
CDGSH iron-sulfur domain-containing protein 2 (CISD2) CISD protein family Q8N5K1
Gap junction beta-5 protein (GJB5) Connexin family O95377
Cytochrome b-245 chaperone 1 (CYBC1) CYBC1 family Q9BQA9
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Integrin beta-2 (ITGB2) Integrin beta chain family P05107
Epithelial membrane protein 1 (EMP1) PMP-22/EMP/MP20 family P54849
Sideroflexin-5 (SFXN5) Sideroflexin family Q8TD22
Transmembrane protein 45B (TMEM45B) TMEM45 family Q96B21
Vesicle transport protein USE1 (USE1) USE1 family Q9NZ43
Protein YIPF6 (YIPF6) YIP1 family Q96EC8
Protein TMED8 (TMED8) . Q6PL24
Receptor-binding cancer antigen expressed on SiSo cells (EBAG9) . O00559
Signaling threshold-regulating transmembrane adapter 1 (SIT1) . Q9Y3P8
Transmembrane protein 52B (TMEM52B) . Q4KMG9

References

1 Tranylcypromine specificity for monoamine oxidase is limited by promiscuous protein labelling and lysosomal trapping. RSC Chem Biol. 2020 Aug 12;1(4):209-213. doi: 10.1039/d0cb00048e. eCollection 2020 Oct 1.
Mass spectrometry data entry: PXD018580
2 Design and synthesis of tailored human caseinolytic protease P inhibitors. Chem Commun (Camb). 2018 Aug 28;54(70):9833-9836. doi: 10.1039/c8cc05265d.
Mass spectrometry data entry: PXD010277
3 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
4 Quantitative and Site-Specific Chemoproteomic Profiling of Targets of Acrolein. Chem Res Toxicol. 2019 Mar 18;32(3):467-473. doi: 10.1021/acs.chemrestox.8b00343. Epub 2019 Jan 15.
5 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.
6 Chemoproteomic profiling of targets of lipid-derived electrophiles by bioorthogonal aminooxy probe. Redox Biol. 2017 Aug;12:712-718. doi: 10.1016/j.redox.2017.04.001. Epub 2017 Apr 5.
7 Large-scale chemoproteomics expedites ligand discovery and predicts ligand behavior in cells. Science. 2024 Apr 26;384(6694):eadk5864. doi: 10.1126/science.adk5864. Epub 2024 Apr 26.
Mass spectrometry data entry: PXD041587
8 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.
9 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.
10 Pharmacological Targeting of Vacuolar H(+)-ATPase via Subunit V1G Combats Multidrug-Resistant Cancer. Cell Chem Biol. 2020 Nov 19;27(11):1359-1370.e8. doi: 10.1016/j.chembiol.2020.06.011. Epub 2020 Jul 9.
11 A Global Map of Lipid-Binding Proteins and Their Ligandability in Cells. Cell. 2015 Jun 18;161(7):1668-80. doi: 10.1016/j.cell.2015.05.045.
12 Mapping Protein Targets of Bioactive Small Molecules Using Lipid-Based Chemical Proteomics. ACS Chem Biol. 2017 Oct 20;12(10):2671-2681. doi: 10.1021/acschembio.7b00581. Epub 2017 Sep 20.
Mass spectrometry data entry: PXD007570